WO2018077310A1 - Vitamin c sodium-containing effervescent tablet and preparation method therefor - Google Patents

Abstract

Disclosed is a vitamin C sodium-containing effervescent tablet, comprising the following components in parts by weight: 200-1120 parts of vitamin C sodium, 560-1300 parts of tartaric acid, 600-1500 parts of sodium bicarbonate, and 200-600 parts of sucrose. The present invention targets problems such as existing vitamin C effervescent tablets having high acidity after dissolving, irritating the mouth, throat, oesophagus and gastric mucosa, being unsuitable for long-term use, losing efficacy during storage due to the vitamin C oxidizing easily, and being susceptible to moisture absorption. The vitamin C sodium-containing effervescent tablet is a simple preparation, and has a stable mass.

Description

Effervescent tablet containing vitamin C sodium and preparation method thereof Technical field

The invention belongs to the field of medicines, health foods and foods, and relates to a composition preparation and a preparation method thereof, in particular to an effervescent tablet containing vitamin C sodium and a preparation method thereof.

Background technique

Vitamin C is a commonly used drug or nutritional supplement in the clinic. It is one of the antioxidant vitamins. It is involved in the hydroxylation reaction in the body and is necessary for the formation of bone, tooth, connective tissue and non-epithelial cells. The normal function of bones and blood vessels, increase the resistance to disease, and is one of the essential nutrients for the human body. It is widely used in the prevention and treatment of various diseases.

Effervescent tablets are a novel tablet developed and applied abroad in recent years. The difference between it and ordinary tablets is that it also contains an effervescent disintegrant. When the effervescent tablet is placed in drinking water, under the action of the effervescent disintegrant, a large amount of air bubbles are generated immediately, so that the tablet is quickly formed. Disintegration and melting, sometimes the bubbles generated by disintegration also cause the tablets to roll up and down in the water, accelerating their disintegration and melting. The gas generated when the tablet disintegrates is partially dissolved in the drinking water, so that the drinking water has a soda-like beauty when it is drunk in the mouth. Effervescent tablets have the following advantages: easy to store and carry; rapid disintegration, convenient taking, rapid onset; high bioavailability, can improve clinical efficacy; especially suitable for children, the elderly and patients who have difficulty swallowing pills; After the seasoning of the effervescent tablets, the taste is better, the medicine is no longer bitter, so that consumers or patients are more willing to accept.

Vitamin C effervescent tablets are included in the second edition of the 2015 Chinese Pharmacopoeia. They are commonly used drugs in clinical practice. Because of the oxidative failure of vitamin C, effervescent tablets are prone to moisture absorption and dampness. Therefore, the use effect of vitamin C effervescent tablets and The shelf life is greatly affected. And the pH value of the aqueous solution of vitamin C is close to 2, and the acidity is large. Oral use is more irritating to the oral cavity, throat esophagus and gastric mucosa. It is not suitable for long-term use, and it is not suitable for taking it with acidic drugs. It is used as a nutrient for daily use or as a nutrient. The treatment or prevention of clinical diseases is limited.

Vitamin C sodium is the sodium salt of vitamin C. The pH of the aqueous solution is close to neutral. It has the same effect as vitamin C, but because it is sodium salt, the performance is more stable. At the same time, there is no longer strong acidity of vitamin C. The drug is taken at the same time, which is better than vitamin C. Vitamin C sodium is a vitamin C fortifier widely used at home and abroad and has been gradually replaced by vitamin C. The invention directly forms vitamin C sodium into effervescent tablets, and the preparation is safe and effective through clinical trials. At present, no relevant literature reports have been reported.

Summary of the invention

The invention aims at the problem that the existing vitamin C effervescent tablet has high acidity after dissolution, is irritating to the oral cavity, the throat esophagus and the gastric mucosa, and is not suitable for long-term use, and the vitamin C is easily oxidized and failed during storage, and the effervescent tablet is easy to absorb moisture and damp. Provide a kind The effervescent tablet containing vitamin C sodium and the preparation method thereof solve the problem that the quality of the clinical application of vitamin C is unstable and difficult to be taken for a long time. The effervescent tablet containing vitamin C sodium has simple preparation and stable quality, and can be used for treating scurvy, infectious diseases, purpura, muscle weakness, paralysis, arrhythmia or renal dysfunction, or for malignancy. Prevention and treatment of tumors, cardiovascular and cerebrovascular diseases, infectious diseases or autoimmune diseases; or long-term use as a nutritional supplement.

In order to solve the above technical problems, the present invention is achieved by the following technical solutions:

An effervescent tablet containing vitamin C sodium, comprising the following components by weight: 200-1120 parts of vitamin C sodium, 560-1300 parts of tartaric acid, 600-1500 parts of sodium hydrogencarbonate, and 200-600 parts of sucrose.

The above-mentioned vitamin C sodium-containing effervescent tablet preferably further comprises the following components by weight: 20-50 parts of a sweetener, 0.2-1 part of a pigment, and 2-8 parts of a flavor.

The above-mentioned vitamin C sodium-containing effervescent tablet further preferably further comprises 0.5 to 1.0% of trehalose and 0.2 to 0.4% of polyethylene glycol based on the total weight of the above components. 6000.

The above-mentioned vitamin C sodium-containing effervescent tablet preferably comprises the following components by weight: 850 parts of vitamin C sodium, 900 parts of tartaric acid, 1000 parts of sodium hydrogencarbonate, 350 parts of sucrose, 35 parts of sweetener, The pigment was 0.6 parts and the fragrance was 5 parts, and further included trehalose which was 0.8% by weight based on the total weight of the above components and polyethylene glycol 6000 which was 0.3% by weight based on the total weight of the above components.

The above-mentioned vitamin C sodium-containing effervescent tablet is preferably aspartame, neotame or mogroside.

In the above-mentioned effervescent tablet containing vitamin C sodium, the pigment is preferably lemon yellow, amaranth, and bright blue.

The above-mentioned vitamin C sodium-containing effervescent tablet is preferably a sweet orange flavor or a blueberry flavor.

The above-mentioned vitamin C sodium-containing effervescent tablets, the acidity measurement and acidity value should preferably meet the following requirements: take the effervescent tablet, add cold water or warm water to disintegrate, make 1g solution per 100ml, to be collapsed After the solution is completely bubble free, the pH is determined to be 4.5 to 6.5; preferably the pH is 5.0 to 6.0.

A method for preparing an effervescent tablet containing the above vitamin C sodium comprises the following steps:

S1. Weigh the following parts by weight: vitamin C sodium 200-1120 parts, tartaric acid 560-1300 parts, sodium bicarbonate 600-1500 parts, sucrose 200-600 parts, sweetener 20-50 parts, pigment 0.2- 1 part, 2-8 parts of flavor; further weigh 0.5-1.0% of the total weight of the above components of trehalose and 0.2-0.4% of the total weight of the above components of polyethylene glycol 6000;

S2. Boiling the water, adding trehalose and the above-mentioned part of the weighed sucrose, stirring to dissolve, continuing to heat to 100 ° C, filtering, to obtain a filtrate, adding water to the filtrate, the above-mentioned weighed pigment, mixed Evenly, a syrup pigment solution containing 30-60% by weight of sucrose;

S3. Take tartaric acid, the remaining sucrose and sweetener under step S2, mix, add 30-60% syrup pigment solution obtained under step S2, mix, granulate, sieve, dry, and granulate. Acid agent

S4. Take sodium bicarbonate, add the remaining 30-60% of the syrup pigment solution under step S3, mix, granulate, sieve, dry, and granulate to obtain an alkali agent;

S5. Take acid, vitamin C sodium, essence, mix, add alkali agent, polyethylene glycol 6000, mix, tablet, that is.

Further, the drying temperature described in the steps S3 and S4 is preferably 80 ° C or lower, and the obtained particles have a moderate hardness, which is more favorable for tableting and facilitates disintegration; and the steps S3 and S4 are as described below. The screen used for the sieving step is preferably 14-30 mesh.

The beneficial effects of the invention are:

1. The invention overcomes the problem that the existing vitamin C effervescent tablet has high acidity after dissolution, is irritating to the oral cavity, throat esophagus and gastric mucosa, and is not suitable for long-term use, and the vitamin C is easily oxidized and failed during storage, and the effervescent tablet is easy to absorb moisture and damp. The problem is to make the product more stable and more effective. It is suitable for long-term use by consumers or patients without side effects.

2. The invention can be used for treating diseases such as scurvy, infectious diseases and purpura, such as muscle weakness, paralysis, arrhythmia or renal dysfunction, and can also be used for malignant tumors, cardiovascular and cerebrovascular diseases, infectious diseases and autoimmunity. Prevention and treatment of major and difficult diseases such as sexually transmitted diseases; or long-term use as a nutritional supplement.

3. The effervescent tablet containing vitamin C sodium of the invention has simple preparation, good fluidity of the particles, and the tablet is not sticky, and the prepared tablet has a smooth surface, is not easy to absorb moisture, has uniform effervescent gas production, and has short disintegration time. After disintegration, the solution is transparent and clear, the taste is sweet, the quality is stable, and the carrying is convenient. It has the characteristics of solid preparation and liquid preparation, especially suitable for children, the elderly and patients who cannot swallow solid preparations, with high bioavailability and safer use. effective.

detailed description

While the specification concludes with particular reference to the claims of the invention, it is believed that

As used herein, the word "preferred" and variants refers to embodiments of the invention that are capable of providing a particular benefit in a particular environment. However, other embodiments may be preferred under the same or other circumstances. In addition, the detailed description of one or more preferred embodiments does not indicate that other embodiments are useless and are not intended to exclude other embodiments from the scope of the invention.

First, the screening of preparation conditions

1. Selection of acid source and alkali source

The acid sources commonly used in effervescent tablets are tartaric acid, citric acid, fumaric acid, adipic acid, malic acid, etc.; alkali sources include sodium hydrogencarbonate, potassium carbonate, potassium hydrogencarbonate, calcium carbonate and the like. The effervescent tablet prepared by using sodium hydrogencarbonate as an alkali source can rapidly disintegrate in water, and the pH of the effervescent solution is suitable for the stabilization of vitamin C sodium, so the alkali source of the present invention selects sodium hydrogencarbonate. The fixed alkali source is sodium bicarbonate On the basis of the following formula, the selection of tartaric acid, citric acid, fumaric acid, malic acid, adipic acid was tested to determine the best source of acid in the effervescent tablet.

Table 1 Preferred test of acid source and alkali source

Serial number	Vitamin C sodium (g)	Sucrose (g)	Acid source (g)	test results
1	100	30	tartaric acid	The granulation effect is good, the tablet is sticky, the effervescence disintegration time is short, the solution is clear, and the taste is good.
2	100	30	Citric acid	Difficulty in granulation, tableting and blunting, short effervescent disintegration time, clear solution, good taste
3	100	30	Fumaric acid	Granulation, tableting effect, effervescent disintegration time, solution turbidity
4	100	30	Malic acid	Difficulty in granulation, tableting and blunting, short effervescent disintegration time, clear solution, good taste
5	100	30	Adipic acid	Good granulation and tableting, long effervescent disintegration

It can be seen from the test results in Table 1 that the present invention uses tartaric acid mixed with vitamin C sodium, sodium hydrogencarbonate and sucrose to form granules, has a short disintegration time, clarifies the solution, and has a good mouthfeel, but has a sticking phenomenon when tableting. Compared with other acid sources, the acid source of the present invention selects tartaric acid, and the alkali source selects sodium hydrogencarbonate.

2. Adhesive selection

The invention compares the dry pressing tablet, the wet granulation and the re-pulling, the dry pressing tablet adopts the ordinary tableting machine has a poor effect and has high requirements on the equipment, so the invention adopts the wet granulation and the tableting. In the test, 30% starch slurry, 40% sucrose syrup, 5% hypromellose aqueous solution, and 85% ethanol were used as binders. The results are shown in Table 2.

Table 2 Adhesive inspection results table

It can be seen from the test results in Table 2 that the granulation effect and the effervescence effect of the 40% sucrose syrup of the present invention are the best, and the sucrose syrup is selected as the binder of the present invention. In order to further optimize the syrup concentration, the present invention continues to optimize the sucrose syrup concentration, and the test results are shown in Table 3.

Table 3 Table of results of syrup concentration investigation

Serial number	Adhesive	Granulation	Particle appearance	Effervescent effect
1	20% sugar syrup	Not in a group, difficult to pelletize	Granular pine	Effervescent disintegration time 3 minutes, solution clarification
2	30% sugar syrup	In a cluster, granulation does not agglomerate	Suitable for loose particles	Effervescent disintegration time 3 minutes, solution clarification
3	50% syrup syrup	In a cluster, granulation does not agglomerate	Suitable for loose particles	Effervescent disintegration time 3.5 minutes, solution clarification
4	60% sugar syrup	In a cluster, granulation does not agglomerate	Suitable for loose particles	Effervescent disintegration time 3.5 minutes, solution clarification
5	70% sugar syrup	In a cluster, granulation does not agglomerate	Suitable for loose particles	Effervescent disintegration time 5.5 minutes, solution clarification

It can be seen from the test results in Table 3 that the granulation of 30%-60% sucrose syrup and the effervescence effect of the present invention are better, the concentration is too low, and the concentration is too high, which affects the effervescence time, so the adhesive of the present invention is selected 30 %-60% sucrose syrup.

3. Selection of stabilizers

Vitamin C sodium is the sodium salt of vitamin C, which is more stable than vitamin C, but is prepared as an effervescent tablet in an acid agent. The effects of alkaline agents, other excipients, and moisture and oxidation in the air must ensure that the quality of the product is stable during the shelf life, or that stabilizers need to be added. In the test, 0.02% EDTA disodium, 1% trehalose, and 0.2% sodium sulfite were compared. The samples prepared by the above stabilizers were respectively packaged with aluminum-plastic composite film, and the stability was accelerated in the test chamber: temperature: 40±2°C, relative humidity: 75±5%, accelerated test for 3 months, the test results are shown in Table 4.

Table 4 Stabilizer test results table

It can be seen from the test results in Table 4 that the use of disodium EDTA and sodium sulfite as a stabilizer has a large change in water content, which tends to cause an internal reaction of the acid agent alkali, a decrease in the pH of the solution and an accelerated oxidation, resulting in a decrease in the vitamin C content. With 1% trehalose as a stabilizer, after the accelerated test, the moisture does not change much, and the appearance, effervescence reaction time, solution pH and vitamin C sodium content change little, so the present invention uses 1% trehalose as a stabilizer, for which, The amount of trehalose added was further investigated and the obtained sample was subjected to an accelerated test. The test method was the same as in Table 4, and the results are shown in Table 5.

Table 5 Test results of the amount of trehalose added

From the test results in Table 4, it can be seen that the moisture, appearance, effervescence reaction time, solution pH and vitamin C sodium content of the effervescent tablet are changed after adding 0.2-0.4% trehalose; and 0.5-1.0% trehalose is contained. The physical and chemical indicators of the effervescent tablets changed little during the acceleration period of 3 months, and the quality was stable. The appearance, pH value and content index of the effervescent tablets containing 1.2-1.5% trehalose did not change during the acceleration period of 3 months. Large, the quality is still stable during the 3 months acceleration period, but the change of water and effervescence reaction time exceeds the quality standard. Therefore, the amount of trehalose controlled by the present invention is 0.5-1.0%.

4. Selection of lubricants

The material of the invention before the tableting has acid agent, vitamin C sodium, essence, alkali agent, material particle size and texture unevenness, poor particle flowability when tableting, and easy sticking when tableting. In the test of the present invention, the other formulas except the lubricant are the same. After the preliminary test determines the available ratio, the different amounts of dodecyl magnesium sulfate, polyethylene glycol 6000, mannitol are specifically compared, and the above lubricants are respectively used. The prepared samples were packaged with aluminum-plastic composite film respectively, and the stability test was accelerated in the test chamber: temperature: 40±2°C, relative humidity: 75±5%, accelerated test for 3 months, and the results are shown in Table 6.

Table 6 Lubricant Trial Results Table

From the test results in Table 4, it is known that the flowability of adding 0.2-0.5% polyethylene glycol 6000 is good, and the tableting is not sticky, and the sheet surface is smooth and beautiful, but the accelerated test found that the amount of 6000 added polyethylene glycol increased, including As the amount of water increases, the effervescent reaction time also increases a lot, which does not meet the requirements for the disintegration time of the effervescent agent. Therefore, the present invention selects 0.2-0.4% of polyethylene glycol 6000 as a lubricant.

5. Selection of sweeteners

After the effervescent tablet disintegrates, it is a beverage-like liquid. Therefore, the flavor and taste are very important. The effervescent tablet is small in volume, the sample loading is small, and the sweetness of simple sucrose is not enough. In the test, the following sweeteners are compared: stevia, licorice Acid disodium, aspartame, sodium saccharin, sodium cyclamate, mogroside, neotame, and alitame, the results show that: the above sweeteners are aspartame, mogroside, neotame In the range of the components of the "sweetener 20-50 parts", the taste is good, the sweetness is moderate, and there is no discomfort, and the aspartame tastes best. Therefore, the present invention selects aspartame, mogroside, and neotame as sweeteners, and the amount thereof is 20-50 parts.

2. Preparation method of effervescent tablet containing vitamin C sodium

Example 1

The preparation method of the effervescent tablet containing vitamin C sodium includes the following steps:

S1. Weigh the following components: vitamin C sodium 56 kg, tartaric acid 56 kg, sodium bicarbonate 60 kg, sucrose 20 kg, neotame 2 kg, lemon yellow 0.02 kg, sweet orange flavor 0.2 kg, and then weighed the above group 9.7 g of trehalose having a total weight of 0.5% and 6000388 g of polyethylene glycol accounting for 0.2% of the total weight of the above components;

S2. boil the water, add trehalose, and then add 8kg from the above weighed sucrose to the boiling water, stir to dissolve, continue to heat to 100 ° C, filter, obtain the filtrate, add the appropriate amount of water in the filtrate and The above-mentioned weighed lemon yellow is mixed and obtained a syrup pigment solution containing 30% by weight of sucrose;

S3. Take tartaric acid, 12kg of sucrose and neotame in step S2, mix well, add appropriate 30% syrup pigment solution obtained under step S2, mix, granulate, pass 14 mesh sieve, dry at 80 °C, Whole grain, acidifier;

S4. Take sodium bicarbonate, add the remaining 30% syrup pigment solution under step S3, mix well, then add the appropriate amount of 60% Ethanol granulation, passing through a 14 mesh sieve, drying at 80 ° C, granules, to obtain an alkali agent;

S5. Take acid, vitamin C sodium, sweet orange flavor, mix, add alkali agent, polyethylene glycol 6000, mix, tablet, that is.

Example 2

The preparation method of the effervescent tablet containing vitamin C sodium includes the following steps:

S1. Weigh the following components: vitamin C sodium 112 kg, tartaric acid 130 kg, sodium bicarbonate 150 kg, sucrose 50 kg, mogroside 5 kg, amaranth 0.1 kg, blueberry flavor 0.8 kg, and then weighed the above group The total weight of 1.0% of trehalose 4421g and the total weight of the above components of 0.4% of polyethylene glycol 60001768g;

S2. The water is boiled, trehalose is added, and 40 kg of the above weighed sucrose is added to the boiling water, stirred to dissolve, and the mixture is further heated to 100 ° C, filtered to obtain a filtrate, and an appropriate amount of water is added to the filtrate. The above-mentioned weighed amaranth is mixed, and a syrup pigment solution containing 60% by weight of sucrose is obtained;

S3. Take tartaric acid, 10kg of sucrose, and sucrose glycosides under step S2, mix well, add appropriate amount of 60% syrup pigment solution obtained under step S2, mix, granulate, pass 30 mesh sieve, dry at 100 °C , whole grain, acidifier;

S4. Take sodium bicarbonate, add the remaining 60% syrup pigment solution under step S3, mix well, then add appropriate amount of 100% ethanol granules, pass through a 30 mesh sieve, dry at 60 ° C, and granulate to obtain an alkali agent;

S5. Take acid, vitamin C sodium, blueberry flavor, mix, add alkali agent, polyethylene glycol 6000, mix, tablet, that is.

Example 3

The preparation method of the effervescent tablet containing vitamin C sodium includes the following steps:

S1. Weigh the following components: vitamin C sodium 85kg, tartaric acid 90kg, sodium bicarbonate 100kg, sucrose 35kg, aspartame 3.5kg, bright blue 0.06kg, blueberry flavor 0.5kg, and then weighed above 2512g of trehalose having a total weight of 0.8% of the component and 6000942g of polyethylene glycol accounting for 0.3% of the total weight of the above components;

S2. boil the water, add trehalose, and then add 15kg from the above weighed sucrose to the boiling water, stir to dissolve, continue to heat to 100 ° C, filter, obtain the filtrate, add the appropriate amount of water in the filtrate and The above-mentioned weighed bright blue is mixed and obtained a syrup pigment solution containing 40% by weight of sucrose;

S3. Take tartaric acid, 20kg of sucrose and aspartame under step S2, mix well, add 40% syrup pigment solution obtained under step S2, mix, granulate, pass 20 mesh sieve, dry at 70 °C , whole grain, acidifier;

S4. Take sodium bicarbonate, add the remaining 40% syrup pigment solution under step S3, mix well, then add appropriate amount of 60% ethanol granules, pass 20 mesh sieve, dry at 70 ° C, whole granules, get alkali agent;

S5. Take acid, vitamin C sodium, blueberry flavor, mix, add alkali agent, polyethylene glycol 6000, mix, tablet, That is.

Third, the stability test

The samples of the above Examples 1-3 were respectively packaged with an aluminum-plastic composite film, and the stability was accelerated in the test chamber: temperature: 40±2° C., relative humidity: 75±5%, accelerated test for 3 months, and the results were as follows. The appearance characteristics, moisture, effervescence reaction time, solution pH value, main component content and other stability of the 1-3 samples were compared with the results of the samples at 0, and there was no significant change, the sweetness was moderate, and the taste of the taste did not change. It is to be noted that the sample of the embodiment 1-3 of the invention is relatively stable in quality and can meet the stability requirements of storage, transportation and use. The test results are shown in Table 7.

Table 7 Table of results of stability test of effervescent tablets of sodium vitamin C

Claims (12)

1. An effervescent tablet containing vitamin C sodium, comprising the following components by weight: 200-1120 parts of vitamin C sodium, 560-1300 parts of tartaric acid, 600-1500 parts of sodium hydrogencarbonate, 200-600 parts of sucrose .
2. The vitamin C-containing effervescent tablet according to claim 1, which further comprises the following components by weight: 20-50 parts of a sweetener, 0.2-1 part of a pigment, and 2-8 parts of a flavor.
3. The vitamin C sodium-containing effervescent tablet according to claim 2, which further comprises 0.5 to 1.0% of trehalose based on the total weight of the above components and 0.2 to 0.4% by weight based on the total weight of said components. Polyethylene glycol 6000.
4. The vitamin C sodium-containing effervescent tablet according to claim 3, which comprises the following components by weight: 850 parts of vitamin C sodium, 900 parts of tartaric acid, 1000 parts of sodium hydrogencarbonate, 350 parts of sucrose, and sweetness. 35 parts of the agent, 0.6 parts of the pigment, and 5 parts of the essence also included trehalose in an amount of 0.8% by weight based on the total weight of the above components and polyethylene glycol 6000 in an amount of 0.3% based on the total weight of the above components.
5. The vitamin C sodium-containing effervescent tablet according to claim 2 or 4, wherein the sweetener is aspartame, neotame, and mogroside.
6. The vitamin C sodium-containing effervescent tablet according to claim 2 or 4, wherein the pigment is lemon yellow, amaranth, and bright blue.
7. The vitamin C sodium-containing effervescent tablet according to claim 2 or 4, wherein the flavor is a sweet orange flavor and a blueberry flavor.
8. The effervescent tablet containing vitamin C sodium according to any one of claims 1 to 7, which is characterized in that an effervescent tablet is taken, and cold water or warm water is added to disintegrate to prepare a solution containing 1 g per 100 ml to be disintegrated. After completely no bubbles, the pH was determined to be 4.5-6.5.
9. The effervescent tablet containing vitamin C sodium according to any one of claims 1 to 7, which is characterized in that an effervescent tablet is taken, and cold water or warm water is added to disintegrate, and a solution containing 1 g per 100 ml is prepared. After the disintegration was completely free of bubbles, the pH was measured to be 5.0 to 6.0.
10. A method for preparing a vitamin C sodium-containing effervescent tablet according to claim 3, comprising the steps of:

    S1. Weigh the following parts by weight: 200-1120 parts of vitamin C sodium, 560-1300 parts of tartaric acid, 600-1500 parts of sodium bicarbonate, 200-600 parts of sucrose, 20-50 parts of sweetener, 0.2 coloring agent 1 part, 2-8 parts of flavor, further weigh 0.5-1.0% of the total weight of the above components of trehalose and 0.2-0.4% of the total weight of the above components of polyethylene glycol 6000;

    S2. Boiling the water, adding trehalose and the above-mentioned part of the weighed sucrose, stirring to dissolve, continuing to heat to 100 ° C, filtering, to obtain a filtrate, adding water to the filtrate, the above-mentioned weighed pigment, mixed Evenly, a syrup pigment solution containing 30-60% by weight of sucrose;

    S3. Take tartaric acid, the remaining sucrose and sweetener under step S2, mix and add 30-60% of the obtained under step S2. Syrup pigment solution, mixing, granulating, sieving, drying, granulating, acidifying agent;

    S4. Take sodium bicarbonate, add the remaining 30-60% of the syrup pigment solution under step S3, mix, granulate, sieve, dry, and granulate to obtain an alkali agent;

    S5. Take acid, vitamin C sodium, essence, mix, add alkali agent, polyethylene glycol 6000, mix, tablet, that is.
11. The method for producing a vitamin C-containing effervescent tablet according to claim 8, wherein the drying temperature in the step S3 and the step S4 is 80 ° C or lower.
12. The method for producing a vitamin C sodium-containing effervescent tablet according to claim 8, wherein the sieve used in the sieving step described in the steps S3 and S4 is 14 to 30 mesh.