CN107049982A - A kind of ion VC pills and preparation method thereof - Google Patents

A kind of ion VC pills and preparation method thereof Download PDF

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Publication number
CN107049982A
CN107049982A CN201710402317.1A CN201710402317A CN107049982A CN 107049982 A CN107049982 A CN 107049982A CN 201710402317 A CN201710402317 A CN 201710402317A CN 107049982 A CN107049982 A CN 107049982A
Authority
CN
China
Prior art keywords
parts
ion
pills
sodium
potassium chloride
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710402317.1A
Other languages
Chinese (zh)
Inventor
黄爱强
黄爱毅
刘伟林
黎露清
孙家程
何洪群
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hall Of Fangchenggang Pharmaceutical Co Ltd
Original Assignee
Hall Of Fangchenggang Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hall Of Fangchenggang Pharmaceutical Co Ltd filed Critical Hall Of Fangchenggang Pharmaceutical Co Ltd
Priority to CN201710402317.1A priority Critical patent/CN107049982A/en
Publication of CN107049982A publication Critical patent/CN107049982A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/282Organic compounds, e.g. fats
    • A61K9/2826Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365Lactones
    • A61K31/375Ascorbic acid, i.e. vitamin C; Salts thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2009Inorganic compounds
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention discloses a kind of ion VC pills and preparation method thereof, it is characterised in that is made up of the raw material of following weight proportion:0.5 5 parts of vitamine C sodium, 1 10 parts of potassium chloride, 0 100 parts of binder, 0 100 parts of filler, 05 parts of lubricant, 0 20 parts of flavouring, 01 parts of pigment;The invention has the advantages that:Fill up the blank of domestic ion VC pills, there is provided it is a kind of safely, effectively, quick-acting, steady quality ion VC pills and preparation method thereof, expand the scope of application of vitamine C sodium, solve the use limitation that vitamin C is orally brought, can also reduce it and bring more adverse reaction.

Description

A kind of ion VC pills and preparation method thereof
Technical field
The invention belongs to food, health food, medicine field, it is related to a kind of composite preparation and preparation method thereof, especially It is to be related to a kind of ion VC pills and preparation method thereof.
Background technology
Discoloration is decomposed because vitamin C is especially oxidizable, the quality problems such as quality is unstable, mass fraction declines occurs, So as to influence product quality and drug safety;Because vitamin C has highly acid, this brings certain potential safety hazard and more to product Adverse reaction.
Vitamine C sodium(That is L-AA sodium)Effect it is identical with vitamin C, but due to being sodium salt, so performance is more It is stable, while there is no ascorbic highly acid, can simultaneously be taken with multi-medicament, better than vitamin C;Vitamine C sodium Exist after into human body with ion vc state, it is easier to be absorbed by the body, participate in internal a variety of metabolic processes of human body.
The vitamine C sodium pill that the present invention is developed can overcome vitamin C strong acid close to neutrality in clinical heavy dose of medication Property brings adverse reaction and drug combination limitation;Meanwhile, also vitamin C can be higher than due to vitamine C sodium stability, improved Drug quality;Take in excessive sodium ion and easily cause hypertension, potassium chloride is with the addition of in the present invention, for balancing vitamine C sodium In sodium ion so that pill of the invention takes safer, and the scope of application is wider.
The content of the invention
For background technology problem encountered, it is an object of the invention to provide it is a kind of safely, effectively, quick-acting, quality Stable ion VC pills and preparation method thereof.
In order to achieve the above object, the present invention is adopted the following technical scheme that:A kind of ion VC pills, it is characterised in that by The raw material composition of following weight proportion:
0.5-5 parts of vitamine C sodium, 1-10 parts of potassium chloride, 0-100 parts of binder, 0-100 parts of filler, 0-5 parts of lubricant is rectified 0-20 parts of taste agent, 0-1 parts of pigment.
As an improvement, being made up of the raw material of following weight proportion:5 parts of vitamine C sodium, 1 part of potassium chloride, binder 100 Part, 5 parts of lubricant, 1 part of pigment.
As an improvement, being made up of the raw material of following weight proportion:0.5 part of vitamine C sodium, 10 parts of potassium chloride, filler 100 Part, 20 parts of flavouring.
As an improvement, being made up of the raw material of following weight proportion:3 parts of vitamine C sodium, 5 parts of potassium chloride, 46 parts of binder, 55 parts of filler, 3 parts of lubricant, 9 parts of flavouring, 0.6 part of pigment.
As an improvement, binder is:Fructose syrup, syrup, sucrose, starch, powder-beta-dextrin, one kind of microcrystalline cellulose or several Kind.
As an improvement, filler is:One or more in lactose, starch, pregelatinized starch, sucrose, mannitol etc..
As an improvement, flavouring is:Essence, fruit powder, mannitol, citric acid, malic acid, stevioside, xylitol, different malt Ketose, Aspartame, the one or more of lactitol.
Another object of the present invention is to provide a kind of preparation method of ion VC pills, comprised the following steps:By potassium chloride and glutinous Mixture, filler crushed 100 mesh sieves, added vitamine C sodium, flavouring, lubricant and pigment and were well mixed, softwood processed, pressure Ball is made, parcel sugar-coat is produced.
Compared with prior art, the invention has the advantages that:Filling up the blank of domestic ion VC pills, there is provided one Kind safely, effectively, quick-acting, steady quality ion VC pills and preparation method thereof, expand the scope of application of vitamine C sodium, solution Certainly vitamin C is orally brought
Use limitation, can also reduce it and bring more adverse reaction.
Embodiment
In order to be better understood from the purpose of the present invention, feature and effect etc., with reference to skill of the specific embodiment to the present invention Art scheme is described further.
Embodiment 1
A kind of ion VC pills, are made up of the raw material of following weight proportion:5 parts of vitamine C sodium, 1 part of potassium chloride, binder 100 Part, 5 parts of lubricant, 1 part of pigment.
Binder is:Fructose syrup, syrup, sucrose, starch, powder-beta-dextrin, the one or more of microcrystalline cellulose.
A kind of preparation method of ion VC pills, comprises the following steps:Potassium chloride and binder were crushed into 100 mesh sieves, Add vitamine C sodium, lubricant and pigment well mixed, softwood processed suppresses pelletization, and parcel sugar-coat is produced.
Embodiment 2
A kind of ion VC pills, are made up of the raw material of following weight proportion:0.5 part of vitamine C sodium, 10 parts of potassium chloride, filler 100 parts, 20 parts of flavouring.
Filler is:One or more in lactose, starch, pregelatinized starch, sucrose, mannitol etc..
Flavouring is:Essence, fruit powder, mannitol, citric acid, malic acid, stevioside, xylitol, isomaltoketose, A Si Ba Tian, lactitol one or more.
A kind of preparation method of ion VC pills, comprises the following steps:Potassium chloride and filler were crushed into 100 mesh sieves, added Vitamine C sodium, flavouring and pigment are well mixed, softwood processed, suppress pelletization, and parcel sugar-coat is produced.
Embodiment 3
A kind of ion VC pills, are made up of the raw material of following weight proportion:3 parts of vitamine C sodium, 5 parts of potassium chloride, binder 46 Part, 55 parts of filler, 3 parts of lubricant, 9 parts of flavouring, 0.6 part of pigment.
Binder is:Fructose syrup, syrup, sucrose, starch, powder-beta-dextrin, the one or more of microcrystalline cellulose.
Filler is:One or more in lactose, starch, pregelatinized starch, sucrose, mannitol etc..
Flavouring is:Essence, fruit powder, mannitol, citric acid, malic acid, stevioside, xylitol, isomaltoketose, A Si Ba Tian, lactitol one or more.
A kind of preparation method of ion VC pills, comprises the following steps:Potassium chloride and binder, filler were crushed into 100 mesh Sieve, adds vitamine C sodium, flavouring, lubricant and pigment and is well mixed, softwood processed, suppresses pelletization, and parcel sugar-coat is produced.
Embodiment 4
A kind of ion VC pills, are made up of the raw material of following weight proportion:20 parts of fructose syrup, 0.5 part of vitamine C sodium, chlorination 1 part of potassium, 60 parts of sucrose.
A kind of preparation method of ion VC pills, comprises the following steps:By sucrose, 60 parts are put into sugar dissolving kettle, add water 18 parts Change sugar, 300 mesh screens, vacuum sugar boiling is concentrated into relative density 1.2-1.3, by sucrose, 20 parts of fructose syrup and vitamine C sodium 0.5 part, 1 part of potassium chloride, are well mixed, softwood processed, suppress pelletization, and parcel sugar-coat is produced.
Embodiment 5
A kind of ion VC pills, are made up of the raw material of following weight proportion:Mannitol 20
Part, 5 parts of malic acid, 0.5 part of vitamine C sodium, 1 part of potassium chloride, 0.01 part of essence, 0.2 part of cream, 2 parts of milk powder, titanium dioxide 0.05 part of silicon.
A kind of preparation method of ion VC pills, comprises the following steps:Mannitol, potassium chloride and malic acid crushed 100 Mesh sieve, by 1 part of 5 parts of malic acid, the potassium chloride and 0.5 part of vitamine C sodium, 0.01 part of essence, 2 parts of milk powder after above-mentioned pulverize and sieve It is well mixed, then 0.05 part of 20 parts of mannitol and silica are added with the method for equal increments, it is well mixed, the system of adding water is soft Material, suppresses pelletization, and parcel sugar-coat is produced.
Detailed description above is only the explanation of the preferred embodiments of the invention, non-therefore the limitation present invention the scope of the claims, So, all equivalence techniques changes with carried out by this creation description are both contained in the scope of the claims of the present invention.

Claims (8)

1. a kind of ion VC pills, it is characterised in that be made up of the raw material of following weight proportion:
0.5-5 parts of vitamine C sodium, 1-10 parts of potassium chloride, 0-100 parts of binder, 0-100 parts of filler, 0-5 parts of lubricant is rectified 0-20 parts of taste agent, 0-1 parts of pigment.
2. a kind of ion VC pills as claimed in claim 1, it is characterised in that be made up of the raw material of following weight proportion:Dimension Raw 5 parts of element C sodium, 1 part of potassium chloride, 100 parts of binder, 5 parts of lubricant, 1 part of pigment.
3. a kind of ion VC pills as claimed in claim 1, it is characterised in that be made up of the raw material of following weight proportion:Dimension Raw 0.5 part of element C sodium, 10 parts of potassium chloride, 100 parts of filler, 20 parts of flavouring.
4. a kind of ion VC pills as claimed in claim 1, it is characterised in that be made up of the raw material of following weight proportion:Dimension Raw 3 parts of element C sodium, 5 parts of potassium chloride, 46 parts of binder, 55 parts of filler, 3 parts of lubricant, 9 parts of flavouring, 0.6 part of pigment.
5. a kind of ion VC pills as described in Claims 1-4, it is characterised in that binder is:Fructose syrup, syrup, sugarcane Sugar, starch, powder-beta-dextrin, the one or more of microcrystalline cellulose.
6. a kind of ion VC pills as described in Claims 1-4, it is characterised in that filler is:Lactose, starch, pregelatinated One or more in starch, sucrose, mannitol etc..
7. a kind of ion VC pills as described in Claims 1-4, it is characterised in that flavouring is:Essence, fruit powder, sweet dew Alcohol, citric acid, malic acid, stevioside, xylitol, isomaltoketose, Aspartame, the one or more of lactitol.
8. the preparation method of a kind of ion VC pills as described in Claims 1-4, it is characterised in that comprise the following steps:Will Potassium chloride and binder, filler crushed 100 mesh sieves, added vitamine C sodium, flavouring, lubricant and pigment and were well mixed, Softwood processed, suppresses pelletization, and parcel sugar-coat is produced.
CN201710402317.1A 2017-06-01 2017-06-01 A kind of ion VC pills and preparation method thereof Pending CN107049982A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710402317.1A CN107049982A (en) 2017-06-01 2017-06-01 A kind of ion VC pills and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710402317.1A CN107049982A (en) 2017-06-01 2017-06-01 A kind of ion VC pills and preparation method thereof

Publications (1)

Publication Number Publication Date
CN107049982A true CN107049982A (en) 2017-08-18

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107468647A (en) * 2017-09-14 2017-12-15 南通荣成医药化工有限公司 A kind of ion VC oral liquids

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102824315A (en) * 2012-09-25 2012-12-19 广西金海堂药业有限责任公司 Preparation method of vitamin C micro-pill
CN105832763A (en) * 2016-05-11 2016-08-10 广西圣保堂健康产业股份有限公司 Medicine composition containing sodium L-ascorbate and preparing method of medicine composition
CN106420655A (en) * 2016-10-24 2017-02-22 广西圣保堂健康产业股份有限公司 Effervescent tablet containing vitamin C sodium and preparation method of effervescent tablet
CN106420643A (en) * 2016-10-28 2017-02-22 广西圣保堂健康产业股份有限公司 Sodium vitamin C containing chewable tablet and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102824315A (en) * 2012-09-25 2012-12-19 广西金海堂药业有限责任公司 Preparation method of vitamin C micro-pill
CN105832763A (en) * 2016-05-11 2016-08-10 广西圣保堂健康产业股份有限公司 Medicine composition containing sodium L-ascorbate and preparing method of medicine composition
CN106420655A (en) * 2016-10-24 2017-02-22 广西圣保堂健康产业股份有限公司 Effervescent tablet containing vitamin C sodium and preparation method of effervescent tablet
CN106420643A (en) * 2016-10-28 2017-02-22 广西圣保堂健康产业股份有限公司 Sodium vitamin C containing chewable tablet and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107468647A (en) * 2017-09-14 2017-12-15 南通荣成医药化工有限公司 A kind of ion VC oral liquids

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Application publication date: 20170818