KR20170076496A - Improved solubility and safe amorphous curcuminoid solid dispersion composition and manufacturing method thereof - Google Patents

Abstract

The present invention relates to a solid amorphous curcuminoid solid dispersion composition and a process for producing the amorphous curcuminoid solid dispersion composition. The solid amorphous curcuminoid solid dispersion composition comprises amorphous crystalline amorphous carbomiminoid to improve solubility, and a thermodynamically stable amorphous curcuminoid solid There is an advantage that a dispersion body can be provided.

Description

[0001] The present invention relates to a stable amorphous curcuminoid solid dispersion composition having improved solubility and an improved amorphous curcuminoid solid dispersion composition and a manufacturing method thereof,

The present invention relates to amorphous curcuminoid solid dispersion compositions and processes for their preparation.

Curcuminoids are derived from root germs of turmeric (or turmeric) belonging to the perennial ginger of Zingiberaceae and include curcumin and its analogs, bisdimethoxycoucumin, dimethoxycoucumin, Lt; / RTI > Curculumin, the active ingredient in curcumiminoids, is used as an antioxidant to eliminate active oxygen that causes aging or cancer, anti-cancer activity to inhibit the development of cancer, anti-inflammatory action, antidiabetic action, protection of liver function, prevention of dementia, Inhibitory action, and the like.

Accordingly, researches have been actively conducted to develop products by applying a coumucinidol containing a quercumin, which exhibits the above-described effects, to medicines, foods, health functional foods, and the like. However, quercylminoids have a crystal form and are poorly soluble, and thus have a disadvantage in that they are limited in application to pharmaceuticals, foods, and health functional foods.

Thus, studies have been made to improve the water absorption rate of pepper using the poorly soluble quercumin as a component of pepper (Shoba G et al., Planta Med. 64, 353-356) It is an irritating and irritating ingredient, and it is unreasonable to use it commercially.

Korean Unexamined Patent Publication No. 10-2012-0082433 discloses that the curcuminoids exhibit poor solubility characteristics in the production of beverages containing the curcumin compounds. To improve this, curculuminides are milled and dispersed Thereby preventing agglomeration or sedimentation of the turmeric pigment composition.

Korean Patent No. 10-1418058 discloses that a crystalline form of quercuminino is heated at a temperature of 180-240 캜 which is a melting point or higher and then cooled at a temperature lower than 180 캜 to prepare amorphous curcuminoid and a small amount of edible emulsifier is added To thereby prepare a composition for solubilization of a quercuminoid.

However, the size of the curcumiminoid particles can be reduced by milling the curcuminoside. However, even if it is applied to foods, medicines, cosmetics, etc., precipitation and aggregation can not be prevented, and a granular or solid dispersion It is possible to produce moist granules or solid dispersions having moisture due to the physicochemical properties of surfactants or emulsifiers during the production of sieves and the like, and thus the yield of granules or solid dispersions is considerably lowered.

In addition, a large amount of curcumuminide containing curcumin was added to a solution mixed with an organic solvent and water at a temperature of 180 to 240 ° C, which is higher than the melting point of the solution, so that amorphous amorphous form was produced. However, And it is disadvantageous in that it is not applicable in practical industry and is very poor in terms of utilization. Therefore, there is a need to develop a novel thermodynamically stable manufacturing process which is amorphous, while improving the poor solubility of the kurucinimide containing the quercumin.

Disclosure of the Invention The present invention has been made to overcome the above problems, and it is an object of the present invention to provide an amorphous solid dispersion composition which is prepared by preparing a crystalline form of a quercuminoid in an amorphous form of a quercuminino solid dispersion to improve solubility and thermodynamically stable, There is a purpose.

However, the technical problem to be solved by the present invention is not limited to the above-mentioned problems, and other matters not mentioned can be clearly understood by those skilled in the art from the following description.

One aspect of the present invention provides an amorphous curcuminoid solid dispersion composition which is not heated above a melting point, does not use an organic solvent and a surfactant, is amorphous, thermodynamically stable, and has improved solubility in water . The composition comprises a kurucinimino containing a curcumin, an alginic acid compound, and a neutral polysaccharide.

In the solid dispersion composition, 1 to 7% by weight of the kurucinimide containing the curcumin, 10 to 30% by weight of the alginic acid compound, and 40 to 80% by weight of the heavy polysaccharide may be contained.

The alginic acid compound may include at least one selected from the group consisting of alginic acid, sodium alginate, potassium alginate, and calcium alginate.

The neutral polysaccharide may include at least one selected from the group consisting of pullulan, cardan, microcrystalline cellulose, agar, and starch.

The quercyl minnow may contain 70 to 100% by weight of quercumin.

The amorphous curcuminoid solid dispersion composition may be amorphous with no peak at 2,800 cps intensity when 2 [theta] is 0 to 40 [deg.].

The amorphous curcuminoid solid dispersion composition may be a composition for a health food, a pharmaceutical composition, a composition for a food, or a composition for a cosmetic composition.

Another aspect of the present invention provides a process for preparing an amorphous curcuminoid solid dispersion. The method comprises the steps of: preparing a mixed solution by mixing a crystalline type of quercuminino containing aldehyde, an alginic acid type compound, a neutral polysaccharide, and water; Concentrating and drying the mixed solution under reduced pressure to prepare a granule; And sieving the granules to prepare a solid of a quercuminoid solid dispersion.

0.3 to 3.5 parts by weight of the crystalline form of the kurucylmin, 3 to 10 parts by weight of the alginic acid compound, and 13 to 27 parts by weight of the neutral polysaccharide, relative to 100 parts by weight of the water.

The step of preparing the mixed solution may be performed by stirring at 70 to 100 ° C for 1 to 5 hours.

In the step of producing the granules, the reduced-pressure concentration can be carried out at a temperature of 30 to 70 ° C.

In the step of preparing the above-mentioned quercuminonide solid dispersion, the granules may be sieved with 40 to 80 mesh sieves.

Another aspect of the present invention provides a physiologically active functional product comprising the amorphous curcuminoid solid dispersion composition of the present invention.

The amorphous curcuminoid solid dispersion according to the present invention and amorphous curcuminoid solid dispersion which is amorphous and thermodynamically stable and improved solubility of weakly soluble curcuminoid according to the present invention is a solid dispersion of amorphous curcuminoid, , It can show various effects such as antioxidation, anti-cancer, anti-inflammation, anti-diabetes, protection of liver function, prevention of dementia, and inhibition of fat accumulation.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a graph showing an X-ray diffraction pattern of the amorphous curcuminoid solid dispersion of Example 1 of the present invention and Comparative Example 1. FIG.
2 is a graph showing an X-ray diffraction pattern of the amorphous curcuminoid solid dispersion according to Example 1 of the present invention over time.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. However, the present invention is not limited to the embodiments described herein but may be embodied in other forms. Like reference numerals designate like elements throughout the specification.

Curculuminoid Solid Dispersion Composition

A quercuminino solid dispersion composition according to an embodiment of the present invention includes a quercuminium compound, an alginic acid compound, and a neutral polysaccharide.

The quercuminino-containing quercuminino may be derived from a sulfuric acid, and a powder form thereof may be used. In the amorphous curcuminoid solid dispersion composition, the curcumin content of the curcumin is preferably 1 to 10% by weight, more preferably 3 to 5%, but is not limited thereto. When the curcumin content of the amorphous curcuminoid solid dispersion composition is less than 1% by weight, the effect of physiological activity expressed from the curculuminoid may be insufficient. When the amorphous solid content is more than 10% by weight, Due to the difficulty in forming a sieve, the solubility may be lowered when it is applied to beverages or injection solutions.

The quercuminium may include 70 to 100 wt% of quercumin. When the content of curculumin is less than 70% by weight, the content of the quercuminino in the amorphous curcuminoid solid dispersion composition is increased, and the content of the alginic acid compound or the polysaccharide may be limited.

The alginic acid compounds improve the flowability and physical properties of the solid dispersion together with alginic acid described below as a water-soluble polymer. It can also act as an absorption enhancer to further enhance absorption in the digestive system and act as a thickener with acidic polysaccharides .

In the amorphous curcuminoid solid dispersion composition, the alginic acid compound is preferably contained in an amount of 10 to 30% by weight, more preferably 20 to 30% by weight, but is not limited thereto. In the amorphous curcuminoid solid dispersion composition, when the alginic acid compound is contained in an amount of less than 10% by weight, the solubility of the solid dispersion may be lowered. When the amorphous curcuminoid solid dispersion composition is more than 30% by weight, The content of the polysaccharide can be relatively lowered. The alginic acid compound may include at least one selected from the group consisting of alginic acid, sodium alginate, potassium alginate, and calcium alginate.

The neutral polysaccharides together with the alginic acid compounds improve the flowability and physical properties of the amorphous curcuminoid solid dispersion composition as a water-soluble polymer. In addition, the neutral polysaccharide may serve as the thickener. Thus, the amorphous curcuminoid solid dispersion composition has a role of increasing the viscosity or improving the solubility .

In the amorphous curcuminoid solid dispersion composition, the neutral polysaccharide preferably contains 40 to 80% by weight, more preferably 60 to 80% by weight, but is not limited thereto. When the content of the neutral polysaccharide is less than 40% by weight with respect to the amorphous curcuminoid solid dispersion composition, the amorphous curcuminoid solid dispersion composition may not exhibit amorphous characteristics, and when it exceeds 80% by weight, The elution characteristics may be lowered. The neutral polysaccharide may include at least one selected from the group consisting of pullulan, cardan, microcrystalline cellulose, agar, and starch.

As described above, the solid dispersion composition containing the crystalline form of quercuminino, alginic acid compound, and neutral polysaccharide containing the quercumin content shows amorphous characteristics. Thus, when the composition is applied to foods such as drinks and health functional beverages of medicines, the solubility is excellent, so that precipitation and coagulation in the liquid can be prevented.

Specifically, the amorphous curcuminoid solid dispersion composition may be amorphous with no peaks at 2,800 cps intensity or higher, and preferably no peak at 2,500 cps or higher when 2θ is 0 to 40 °.

The amorphous curcuminoid solid dispersion composition may be a composition for a health food, a pharmaceutical composition, a food composition, or a cosmetic composition.

Process for preparing amorphous curcuminoid solid dispersion

The method for preparing a solid amorphous curcuminoid according to an embodiment of the present invention comprises the steps of: preparing a mixed solution by mixing a crystalline type of quercuminoid containing aluminosilicate compound, a neutral polysaccharide and water, Concentrating and drying the mixed solution under reduced pressure to prepare a granule, and sieving the granule to prepare a solid of a quercuminoid dispersion.

In the step of producing the mixed solution, the description of the crystalline type of quercuminino-containing compound, the alginic acid type compound and the neutral polysaccharide containing the quercumin content is the same as that of the above-mentioned quercumin-containing quercumin, alginic acid compound and neutral polysaccharide The description will be referred to.

0.3 to 3.5 parts by weight of the crystalline form of the kurucylmin, 3 to 10 parts by weight of the alginic acid compound, and 13 to 27 parts by weight of the polysaccharide, relative to 100 parts by weight of the water. If the amount of the crystalline form of the quercuminium compound is less than 0.3 parts by weight based on 100 parts by weight of the water, the effect generated from the quercuminoid may be negligible. If the amount of the amorphous quercuminoid solid dispersion The solubility of the sieve may be lowered.

If the amount of the alginic acid compound is less than 3 parts by weight based on 100 parts by weight of the water, the solubility of the solid dispersion may be lowered. If the amount of the alginic acid compound is more than 10 parts by weight, the polysaccharide content in the amorphous curcuminoid solid dispersion composition may be relatively high Can be lowered.

When the neutral polysaccharide is less than 13 parts by weight based on 100 parts by weight of the water, the amorphous curcuminoid solid dispersion composition may not exhibit amorphous characteristics. When the neutral polysaccharide is more than 27 parts by weight, the content of the alginic acid compound decreases The elution characteristics may be deteriorated.

In addition, the step of preparing the mixed solution may be performed by stirring the mixed solution at 70 to 100 ° C for 1 to 5 hours. At this time, when the temperature condition is less than 70 ° C, the mixing ratio of the crystalline type of quercuminino compound, alginic acid type compound, polysaccharide, and water containing the quercumin is lowered and the solubility of the amorphous curcuminoid solid dispersion may be lowered. Side reactions may occur.

When the mixing time is less than 1 hour, the mixing ratio of the crystalline type of quercuminino-containing compound, alginic acid type compound, polysaccharide, and water containing the quercumin is lowered and the solubility of the amorphous quercuminoid solid dispersion may be deteriorated. If they are exceeded, side reactions may occur.

On the other hand, in the step of producing the granules, the reduced-pressure concentration can be carried out at a temperature of 30 to 70 ° C. At this time, when the reduced pressure concentration temperature is less than 30 ° C or more than 70 ° C, the concentration is not uniformized, and the solid dispersion can be formed in a nonuniform form.

In addition, the step of preparing the solid dispersion of the curcuminoids may be performed by sieving the granules with 40 to 80 mesh sieves. In this case, when sieving with a sieving net having a mesh size of 40 meshes, the solubility of the solid dispersion becomes large, and if it is sieved with a sieving agent having a mesh size exceeding 80 mesh, the process time becomes longer and the yield of the solid dispersion becomes lower have.

Physiologically active functional product

The present invention also provides a physiologically active functional product containing, as an active ingredient, an amorphous curcuminoid solid dispersion composition containing a crystalline form of a quercuminoid, an alginic acid compound, and a polysaccharide containing a curcumin.

The amorphous curcuminoid solid dispersion composition is as described above.

The functional product may be a health food, a pharmaceutical product, a food, or a cosmetic product.

For example, in the health functional food for physiological activity according to an embodiment of the present invention, when the amorphous curcuminoid solid dispersion composition is used as an additive for a health functional food, since the solubility is excellent, Precipitation and flocculation are remarkably low. Therefore, it can be added as it is or can be used together with other food or food ingredients, and can be suitably used according to a conventional method. The amount of the active ingredient to be mixed may be suitably determined according to each use purpose such as prevention, health, or treatment.

Formulations of health functional foods may be in the form of powders, granules, pills, tablets, capsules, as well as in the form of ordinary foods or beverages.

There is no particular limitation on the type of the food, and examples of the food to which the above substance can be added include dairy products including meat, sausage, bread, chocolate, candy, snacks, confectionery, pizza, ramen, other noodles, gums, , Various soups, beverages, tea, drinks, alcoholic beverages, and vitamin complexes, and may include foods in a conventional sense.

Generally, the amorphous curcuminoid solid dispersion composition may be added in an amount of not more than 15 parts by weight, preferably not more than 10 parts by weight based on the raw material, in the production of food or beverage. However, in the case of long-term consumption intended for health and hygiene purposes or for health control purposes, the amount may be less than the above range. Further, since the present invention uses fractions from natural products, there is no problem in terms of safety, Or more.

The beverage in the health functional food according to the present invention may contain various flavors or natural carbohydrates as an additional ingredient such as ordinary beverages. The above-mentioned natural carbohydrates may be monosaccharides such as glucose and fructose, disaccharides such as maltose and sucrose, polysaccharides such as dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol and erythritol. Examples of sweeteners include natural sweeteners such as tau martin and stevia extract, synthetic sweeteners such as saccharin and aspartame, and the like. The ratio of the natural carbohydrate may be about 0.01 to 0.04 g, preferably about 0.02 to 0.03 g per 100 mL of the beverage according to the present invention.

In addition to the above, the health functional food for physiological activity according to the present invention may contain various nutrients, vitamins, electrolytes, flavors, colorants, pectic acid and salts thereof, organic acids, protective colloid thickening agents, pH adjusting agents, stabilizers, preservatives, , A carbonating agent used in carbonated beverages. In addition, the composition for improving sleep of the present invention may contain flesh for the production of natural fruit juice, fruit juice drink and vegetable drink. These components may be used independently or in combination. The ratio of such additives is not limited, but is generally selected in the range of 0.01 to 0.1 parts by weight based on 100 parts by weight of the health functional food of the present invention.

Hereinafter, preferred embodiments of the present invention will be described in order to facilitate understanding of the present invention. However, the following examples are provided only for the purpose of easier understanding of the present invention, and the present invention is not limited by the following examples.

[Example]

Production Example: Production of amorphous curcuminoid solid dispersion

And 4.7% by weight of a powder of curcuminoid (Uma Pharmaceutical Co., Ltd., China) containing 71.5% by weight of Pullulan (Hayashibara, Japan), 23.8% by weight of sodium alginate (KIMICA, Japan) and 75.6% The resulting powder was mixed with 300 mL of water and stirred at 90 캜 for 3 hours and dissolved to obtain a mixed liquid. The solution was concentrated under reduced pressure at 50 캜 to obtain dried granules. Then, the dried granules were sieved through a mesh of 60 mesh sieve to obtain 33.94 g of an amorphous curcuminoid solid dispersion.

[Comparative Example]

Comparative Example  One

Curcuminoids containing 75.6% of quercumin (Ufa Pharmaceutical Co., Ltd., China) were used as Comparative Preparation Example 1.

Comparative Example 2

Ulgum terracimin (Korea, Korea) containing 3% of curcumin was used as comparative preparation example 2.

Comparative Examples 3 to 5

The solid dispersion was prepared under the same conditions as in the above-mentioned Production Example except that the content of curculinidol, sodium alginate, and pullulan was varied as shown in Table 1 below.

Comparative Example 3 Comparative Example 4 Comparative Example 5 Example 1 Curcuminoid 9.0 7.4 7.4 4.7 Sodium alginate 68.3 55.6 37.0 23.8 Pullulan 22.7 37.0 55.6 71.5 Gross weight (%) 100.0

Experimental Example

(One) Identify X-ray diffraction patterns

In order to confirm the X-ray diffraction pattern, the X-ray diffraction pattern was obtained by using the RINT 2000 wide angle goniometer X-ray diffractometer after placing the Example and Comparative Examples 1 to 5 in a quartz capillary of 1 mm diameter respectively. The X-ray diffractometer was measured at 40kV / 100mA, 2θ, 2-40 ° angle range.

As a result of measurement of the X-ray diffraction pattern, it can be seen that, as shown in Fig. 1, the typical characteristic of amorphous exhibiting only a broad diffraction lin is shown in Example 1 alone.

(2) Solubility check

The solid dispersion of Example and Comparative Example 1 was placed in a 15 mL conical tube and each 10 mL of purified water was put into a conical tube and vortexed. The mixture was allowed to stand at 40 ° C for one day and centrifuged at 13,500 rpm for 5 minutes. The supernatant was taken and a saturated solution of the quercuminonide was obtained. The saturated solution of the obtained quercuminonide thus obtained was filtered using a 0.45 mu m PVDF syringe filter, and 1 mL of the filtrate was taken and diluted with 9 mL of acetone and subjected to HPLC analysis. HPLC analysis was carried out using Agilent Eclipse Plus C18 (4.6 × 250 mm, 5 μm, USA) at a flow rate of 1.0 mL / min , And the detection wavelength was 420 nm.

The solubility of the solution in the saturated solution of the quercuminino is shown in Table 2 below.

Comparative Example 1 Example Solubility (/ / mL) 0.01 591.6

As can be seen from Table 2, it was confirmed that it increased about 60,000 times as compared with Comparative Example 1 having a crystalline form in the embodiment having an amorphous characteristic.

(3) 40 ° C / RH 75%  Conditional Quercumin  Content measurement

The solid dispersion prepared in the above Example was stored at an acceleration test condition of 40 ° C / RH and 75%, and the content of curcumin was measured by HPLC after the lapse of time. The content change was measured by the HPLC measurement method described in the above solubility test, and the results of changing the content of curcumin by the passage of time are shown in Table 3 below. At this time, the content (%) of the curcumin is the relative value, which is 100% of the initial concentration of the curcumin.

40 [deg.] C / RH 75%
Storage Time Example Initial 1 week 2 weeks 4 weeks Content of Curcumin (%) 100.0 100.0 99.9 99.9

As can be seen in Table 3, the solid dispersion prepared by the Example was found to have no change in the content of curcumin for 4 weeks at 40 DEG C / RH and 75%.

(4) 40 ° C / RH 75%  Confirmed X-ray Diffraction Pattern Change in Conditions

The X-ray diffraction pattern test was carried out in the same manner as in Experimental Example 1 to confirm whether or not the crystallinity of the solid dispersion prepared according to the above Example was kept at 40 DEG C / RH and 75% after the elapse of time.

As a result of measurement of the X-ray diffraction pattern, it was confirmed that the solid dispersion produced by the example of the present invention did not change to crystallinity with the passage of time as shown in Fig. 2, .

Hereinafter, formulation examples of the composition containing the extract of the present invention will be described, but the present invention is not intended to be limited thereto but is specifically described.

Formulation Example 1: Preparation of powder

Amorphous curcuminoid solid dispersion composition 20 mg

Lactose hydrate 100 mg

Talc 10 mg

The above ingredients were mixed and filled in an airtight container to prepare powders.

Formulation Example 2: Preparation of tablets

Amorphous curcuminoid solid dispersion composition 10 mg

Corn starch 100 mg

100mg of lactose hydrate

Magnesium stearate 2 mg

After mixing the above components, tablets were prepared by tableting according to a conventional method for producing tablets.

Formulation Example 3: Preparation of capsules

Amorphous curcuminoid solid dispersion composition 10 mg

Microcrystalline cellulose 12.8 mg

Sodium starch glycolate 5 mg

Magnesium stearate 0.2 mg

After mixing the above components, the capsules were filled in gelatin capsules according to the usual preparation method of capsules.

Formulation Example 4: Preparation of injection

Amorphous curcuminoid solid dispersion gauges 10 mg

180 mg mannitol

Sterile sterilized water for injection 2974 mg

Sodium dihydrogenphosphate 26 mg

After the above components were mixed, they were prepared with the above ingredient contents per ampoule (2 mL) according to the usual injection preparation method.

Formulation Example 5: Preparation of a liquid preparation

Amorphous curcuminoid solid dispersion composition 10 mg

10 g per isomer

5 g mannitol

Purified water quantity

Lemon incense quantity

The components are dissolved in purified water according to the usual preparation method, and the lemon flavor is added in an appropriate amount. Then, purified water is added to adjust the total volume to 100 mL, sterilized and filled in a brown bottle to prepare a liquid preparation.

Formulation Example 6: Preparation of Health Functional Foods

Amorphous curcuminoid solid dispersion composition 10 mg

Vitamin mixture quantity

Vitamin A acetate  70 [mu] g

Vitamin E  1.0 mg

0.13 mg of vitamin B ₁

0.15 mg of vitamin B ₂

0.5 mg of vitamin B ₆

Vitamin B ₁₂ 0.2 g

Vitamin C  10 mg

Biotin  10 [mu] g

Nicotinic acid amide  1.7 mg

Folic acid  50 [mu] g

Calcium pantothenate  0.5 mg

Mineral mixture  Suitable amount

Ferrous sulfate  1.75 mg

Zinc oxide  0.82 mg

Magnesium carbonate 25.3 mg

Potassium monophosphate  15 mg

Dicalcium phosphate  55 mg

Potassium citrate 90 mg

100 mg of calcium carbonate

Magnesium chloride  24.8 mg

Although the composition ratio of the above-mentioned vitamin and mineral mixture is comparatively mixed with a composition suitable for health food as a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above ingredients are mixed according to a conventional method for producing healthy foods , Granules can be prepared and used in the manufacture of health food compositions according to conventional methods.

Formulation Example 7: Preparation of health drinks

Amorphous curcuminoid solid dispersion gauges 10 mg

Vitamin C  15 g

Vitamin E (powder) 100 g

19.75 g of ferrous lactate

3.5 g of zinc oxide

Nicotinic acid amide 3.5 g

Vitamin A 0.2 g

Vitamin B ₁ 0.25 g

Vitamin B ₂ 0.3 g

Purified water quantitation

The above components were mixed according to a conventional health drink manufacturing method, and the mixture was heated at 85 DEG C for about 1 hour with stirring, and the solution thus prepared was filtered to obtain a sterilized 2-liter container, which was sealed and sterilized, ≪ / RTI >

Although the compositional ratio is relatively mixed with a component suitable for a favorite drink, it is also possible to arbitrarily modify the compounding ratio according to the regional or national preference such as the demand class, the demanding country, and the use purpose.

It will be understood by those skilled in the art that the foregoing description of the present invention is for illustrative purposes only and that those of ordinary skill in the art can readily understand that various changes and modifications may be made without departing from the spirit or essential characteristics of the present invention. will be. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive.

Claims (13)

An amorphous curcuminoid solid dispersion composition comprising a quercuminoid containing a curcumin, an alginic acid compound, and a neutral polysaccharide. The method according to claim 1,
The amorphous curcuminoid solid dispersion composition comprising 1 to 7% by weight of the quercumininoid, 10 to 30% by weight of the alginic acid compound, and 40 to 80% by weight of the neutral polysaccharide . The method according to claim 1,
Wherein the alginic acid compound includes at least one selected from the group consisting of alginic acid, sodium alginate, potassium alginate, and calcium alginate. The method according to claim 1,
Wherein the neutral polysaccharide comprises at least one selected from the group consisting of pullulan, cardan, microcrystalline cellulose, agar, and starch. The method according to claim 1,
The amorphous curcuminoid solid dispersion composition according to claim 1, wherein the curcuminizoid comprises from 70 to 100% by weight of quercumin. The method according to claim 1,
The amorphous curcuminoid solid dispersion composition having no peaks at 2,800 cps strength or more at 2? 0 to 40 °. The method according to claim 1,
The amorphous curcuminoid solid dispersion composition is a composition for a health functional food, a pharmaceutical composition, a food composition, or a cosmetic composition, which is an amorphous curcuminoid solid dispersion composition. Preparing a mixed solution by mixing a crystalline type of quercuminino containing a quercumin, an alginic acid type compound, a neutral polysaccharide, and water;
Concentrating and drying the mixed solution under reduced pressure to prepare a granule; And
And a step of sieving the granules to prepare a solid dispersion of a quercumininoid. 9. The method of claim 8,
Wherein the mixed solution is an amorphous solution containing 0.3 to 3.5 parts by weight of the crystalline type of kurushuminino containing the curcumin, 3 to 10 parts by weight of the alginic acid compound and 13 to 27 parts by weight of the neutral polysaccharide, Process for the production of a quercuminoid solid dispersion 9. The method of claim 8,
Wherein the step of preparing the mixed solution is carried out by stirring at a temperature of 70 to 100 ° C for 1 to 5 hours to prepare an amorphous curcuminoid solid dispersion. 9. The method of claim 8,
In the step of producing the granules, the vacuum concentration is carried out at a temperature of 30 to 70 DEG C, and the amorphous curcuminoid solid dispersion is produced. 9. The method of claim 8,
The process for preparing a solid dispersion of curcuminoids according to claim 1, wherein the granules are sieved with 40 to 80 mesh sieves to prepare an amorphous curcuminoid solid dispersion. A physiologically active functional product comprising the amorphous curcuminoid solid dispersion composition of any one of claims 1 to 7.

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