CN107184579A - A kind of ion VC granules and preparation method thereof - Google Patents
A kind of ion VC granules and preparation method thereof Download PDFInfo
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- CN107184579A CN107184579A CN201710402316.7A CN201710402316A CN107184579A CN 107184579 A CN107184579 A CN 107184579A CN 201710402316 A CN201710402316 A CN 201710402316A CN 107184579 A CN107184579 A CN 107184579A
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- parts
- sucrose
- ion
- granules
- sodium
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- 239000008187 granular material Substances 0.000 title claims abstract description 53
- 238000002360 preparation method Methods 0.000 title claims abstract description 35
- 229930006000 Sucrose Natural products 0.000 claims abstract description 48
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract description 48
- 239000005720 sucrose Substances 0.000 claims abstract description 48
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims abstract description 33
- 229910052708 sodium Inorganic materials 0.000 claims abstract description 33
- 239000011734 sodium Substances 0.000 claims abstract description 33
- 150000002500 ions Chemical class 0.000 claims abstract description 28
- WIGIZIANZCJQQY-UHFFFAOYSA-N 4-ethyl-3-methyl-N-[2-[4-[[[(4-methylcyclohexyl)amino]-oxomethyl]sulfamoyl]phenyl]ethyl]-5-oxo-2H-pyrrole-1-carboxamide Chemical compound O=C1C(CC)=C(C)CN1C(=O)NCCC1=CC=C(S(=O)(=O)NC(=O)NC2CCC(C)CC2)C=C1 WIGIZIANZCJQQY-UHFFFAOYSA-N 0.000 claims abstract description 27
- 235000003599 food sweetener Nutrition 0.000 claims abstract description 27
- 239000003765 sweetening agent Substances 0.000 claims abstract description 27
- 239000011782 vitamin Substances 0.000 claims abstract description 27
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 23
- 239000000843 powder Substances 0.000 claims abstract description 23
- 239000002253 acid Substances 0.000 claims abstract description 13
- 239000002994 raw material Substances 0.000 claims abstract description 12
- 239000000203 mixture Substances 0.000 claims abstract description 5
- 239000003513 alkali Substances 0.000 claims description 27
- 239000000686 essence Substances 0.000 claims description 23
- 235000020985 whole grains Nutrition 0.000 claims description 18
- 239000011122 softwood Substances 0.000 claims description 17
- 239000002245 particle Substances 0.000 claims description 16
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid group Chemical group C(CC(O)(C(=O)O)CC(=O)O)(=O)O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 15
- 238000009777 vacuum freeze-drying Methods 0.000 claims description 12
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 10
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 claims description 10
- 238000005469 granulation Methods 0.000 claims description 9
- 230000003179 granulation Effects 0.000 claims description 9
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical group OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 6
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 6
- 229930195725 Mannitol Natural products 0.000 claims description 6
- 239000004384 Neotame Substances 0.000 claims description 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 6
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 6
- 239000000594 mannitol Substances 0.000 claims description 6
- 235000010355 mannitol Nutrition 0.000 claims description 6
- 235000019412 neotame Nutrition 0.000 claims description 6
- HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical compound CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 claims description 6
- 108010070257 neotame Proteins 0.000 claims description 6
- 235000000346 sugar Nutrition 0.000 claims description 6
- 239000011975 tartaric acid Substances 0.000 claims description 6
- 235000002906 tartaric acid Nutrition 0.000 claims description 6
- NUFKRGBSZPCGQB-FLBSXDLDSA-N (3s)-3-amino-4-oxo-4-[[(2r)-1-oxo-1-[(2,2,4,4-tetramethylthietan-3-yl)amino]propan-2-yl]amino]butanoic acid;pentahydrate Chemical compound O.O.O.O.O.OC(=O)C[C@H](N)C(=O)N[C@H](C)C(=O)NC1C(C)(C)SC1(C)C.OC(=O)C[C@H](N)C(=O)N[C@H](C)C(=O)NC1C(C)(C)SC1(C)C NUFKRGBSZPCGQB-FLBSXDLDSA-N 0.000 claims description 5
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims description 5
- 239000004377 Alitame Substances 0.000 claims description 5
- 108010011485 Aspartame Proteins 0.000 claims description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 5
- 235000019409 alitame Nutrition 0.000 claims description 5
- 108010009985 alitame Proteins 0.000 claims description 5
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims description 5
- 239000000605 aspartame Substances 0.000 claims description 5
- 235000010357 aspartame Nutrition 0.000 claims description 5
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 5
- 229960003438 aspartame Drugs 0.000 claims description 5
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 5
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 5
- 235000015165 citric acid Nutrition 0.000 claims description 5
- 239000001530 fumaric acid Substances 0.000 claims description 5
- 239000008103 glucose Substances 0.000 claims description 5
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 claims description 5
- 239000001630 malic acid Substances 0.000 claims description 5
- 235000011090 malic acid Nutrition 0.000 claims description 5
- 239000000845 maltitol Substances 0.000 claims description 5
- 235000010449 maltitol Nutrition 0.000 claims description 5
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 5
- 229940035436 maltitol Drugs 0.000 claims description 5
- 229910000027 potassium carbonate Inorganic materials 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 5
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 4
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 4
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 4
- 210000000481 breast Anatomy 0.000 claims 1
- 150000005846 sugar alcohols Chemical class 0.000 claims 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract description 19
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract description 7
- 229930003268 Vitamin C Natural products 0.000 abstract description 7
- 235000019154 vitamin C Nutrition 0.000 abstract description 7
- 239000011718 vitamin C Substances 0.000 abstract description 7
- 239000003814 drug Substances 0.000 abstract description 5
- 208000025865 Ulcer Diseases 0.000 abstract description 3
- 239000007963 capsule composition Substances 0.000 abstract description 3
- 201000010099 disease Diseases 0.000 abstract description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 3
- 230000027119 gastric acid secretion Effects 0.000 abstract description 3
- 230000007774 longterm Effects 0.000 abstract description 3
- 231100000397 ulcer Toxicity 0.000 abstract description 3
- 238000009472 formulation Methods 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- -1 ion salt Chemical class 0.000 description 5
- 229960005070 ascorbic acid Drugs 0.000 description 4
- 235000001727 glucose Nutrition 0.000 description 4
- 239000000832 lactitol Substances 0.000 description 4
- 235000010448 lactitol Nutrition 0.000 description 4
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 4
- 229960003451 lactitol Drugs 0.000 description 4
- 235000013305 food Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 241000195493 Cryptophyta Species 0.000 description 1
- 206010057315 Daydreaming Diseases 0.000 description 1
- 101100075747 Drosophila melanogaster Lztr1 gene Proteins 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 208000033065 inborn errors of immunity Diseases 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 208000028529 primary immunodeficiency disease Diseases 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
The invention discloses a kind of ion VC granules and preparation method thereof, prepare 1000g preparations and be made up of the raw material of following weight proportion：500 700 parts of sucrose, 100 500 parts of vitamine C sodium, 10 50 parts of fruit powder, 5 20 parts of sweetener, 1 10 parts of essence；The invention has the advantages that：1st, production ordinary preparation and effervescent formulation, adapt to the demand of various people；2nd, vitamine C sodium is developed into granule, to meet the clinical demand that vitamine C sodium constantly increases new application, solve vitamin C acid big, Disease long-term taking and can be shared to medicine for ulcer that unsuitable gastric acid secretion increases, and capsule formulation takes difficulty；3rd, absorb fast.
Description
Technical field
The invention belongs to medicine, food, field of health care food, it is related to a kind of composite preparation and preparation method thereof, especially
It is to be related to a kind of ion VC granules and preparation method thereof.
Background technology
With the quickening of Modern Live rhythm, social competition is growing more intense, and works overtime, stays up late the daily life of a family as modern just
Meal；The inferior healths such as the thing followed is that body and mind is tired, be short of physical strength, failure of memory, absent minded, hypoimmunity
State, and vitamin C and coffee also just turn into overtime work race, night owl improve immunity and refresh the mind, the indispensability of fatigue-relieving
Product；Vitamin C is used to improve immunity of organisms, but because it is acidity, it is big to gastrointestinal irritability, should not largely it take for a long time,
And vitamine C sodium can also be used for vitamin c supplement, act on identical with ascorbic acid, but due to being ion salt, so performance is more steady
Fixed, while there is no the highly acid of vitamin c, can simultaneously be taken with multi-medicament, better than vitamin c, vitamine C sodium enters
Enter after human body with the presence of ion vc state, it is easier to be absorbed by the body, participate in internal a variety of metabolic processes of human body.
However, vitamine C sodium product forms on the market are more single, it is impossible to adapt to the demand of various people；Therefore, this hair
It is bright that vitamine C sodium is developed into granule, to meet the clinical demand that vitamine C sodium constantly increases new application, solve dimension life
Plain C is acid big, Disease long-term taking and can be shared to medicine for ulcer that unsuitable gastric acid secretion increases, and capsule formulation clothes
With difficulty, and the problem of absorb slow..
The content of the invention
For background technology problem encountered, adapt to each it is an object of the invention to provide one kind
Class crowd demand, absorbs fast, neutral ion VC granules and preparation method thereof.
In order to achieve the above object, the present invention is adopted the following technical scheme that：A kind of ion VC granules, it is characterised in that
1000g preparations are prepared to be made up of the raw material of following weight proportion：500-700 parts of sucrose, 100-500 parts of vitamine C sodium, fruit powder
10-50 parts, 5-20 parts of sweetener, 1-10 parts of essence.
It is preferred that, prepare 1000g preparations and be made up of the raw material of following weight proportion：500 parts of sucrose, vitamine C sodium 500
Part, 10 parts of fruit powder, 20 parts of sweetener, 1 part of essence.
It is preferred that, prepare 1000g preparations and be made up of the raw material of following weight proportion：700 parts of sucrose, vitamine C sodium 100
Part, 50 parts of fruit powder, 5 parts of sweetener, 10 parts of essence.
It is preferred that, prepare 1000g preparations and be made up of the raw material of following weight proportion：600 parts of sucrose, vitamine C sodium 300
Part, 30 parts of fruit powder, 12 parts of sweetener, 5 parts of essence.
It is preferred that, described sweetener is mannitol, lactitol, glucose, sucrose, isomaltoketose, maltitol, sea
Algae sugar, protein sugar, alitame, neotame, the one or more combination of Aspartame.
Another object of the present invention is to provide a kind of preparation method of ion VC granules, it is characterised in that including following step
Suddenly：Vitamine C sodium, fruit powder, essence and sweetener are added by prescription proportioning, is well mixed, adds 50% sucrose solution, make soft
Granule is made in material, granulation, vacuum freeze drying, whole grain.
Another object of the present invention is to provide a kind of another preparation method of ion VC granules, it is characterised in that bag
Include following steps：（1）Sucrose, vitamine C sodium, acid source, fruit powder and sweetener are added by prescription proportioning, is well mixed, adds
Granulates are made in 50% sucrose solution softwood, granulation, vacuum freeze drying, whole grain；
（2）Sucrose, alkali source and essence are added by prescription proportioning, is well mixed, adds 50% sucrose solution softwood, pelletize, very
Alkali particle is made in vacuum freecing-dry, whole grain.
（3）Processing is dried to granulates and alkali particle respectively, afterwards granulates and alkali particle are well mixed, point
Dress, produces effervescence granular.
It is preferred that, described acid source is citric acid, tartaric acid, malic acid, the one or more combination of fumaric acid.
It is preferred that, described alkali source is any one in carbonic acid hydrogen ion, saleratus, carbonate ions, potassium carbonate.
Compared with prior art, the invention has the advantages that：1st, production ordinary preparation and effervescent formulation, adapt to each
The demand of class crowd；2nd, vitamine C sodium is developed into granule, to meet the clinical need that vitamine C sodium constantly increases new application
Ask, solve vitamin C acidity greatly, Disease long-term taking and can be closed to medicine for ulcer that unsuitable gastric acid secretion increases
With, and capsule formulation takes difficulty；3rd, absorb fast.
Embodiment
In order to be better understood from the purpose of the present invention, feature and effect etc., with reference to skill of the specific embodiment to the present invention
Art scheme is described further.
Embodiment 1
A kind of ion VC granules, prepare 1000g preparations and are made up of the raw material of following weight proportion：500 parts of sucrose, vitamin C
500 parts of sodium, 10 parts of fruit powder, 20 parts of sweetener, 1 part of essence.
Sweetener be mannitol, lactitol, glucose, sucrose, isomaltoketose, maltitol, trehalose, protein sugar,
Alitame, neotame, the one or more combination of Aspartame.
A kind of preparation method of ion VC granules, comprises the following steps：By prescription proportioning add vitamine C sodium, fruit powder,
Essence and sweetener, are well mixed, add 50% sucrose solution, and softwood processed is pelletized, vacuum freeze drying, whole grain, are made
Granula.
A kind of another preparation method of ion VC granules, comprises the following steps：（1）Sucrose, dimension are added by prescription proportioning
Raw element C sodium, acid source, fruit powder and sweetener, are well mixed, add 50% sucrose solution softwood, pelletize, vacuum freeze drying,
Whole grain, is made granulates；
（2）Sucrose, alkali source and essence are added by prescription proportioning, is well mixed, adds 50% sucrose solution softwood, pelletize, very
Alkali particle is made in vacuum freecing-dry, whole grain.
（3）Processing is dried to granulates and alkali particle respectively, afterwards granulates and alkali particle are well mixed, point
Dress, produces effervescence granular.
Acid source is citric acid, tartaric acid, malic acid, the one or more combination of fumaric acid.
Alkali source is any one in carbonic acid hydrogen ion, saleratus, carbonate ions, potassium carbonate.
Embodiment 2
A kind of ion VC granules, prepare 1000g preparations and are made up of the raw material of following weight proportion：700 parts of sucrose, vitamin C
100 parts of sodium, 50 parts of fruit powder, 5 parts of sweetener, 10 parts of essence.
Sweetener be mannitol, lactitol, glucose, sucrose, isomaltoketose, maltitol, trehalose, protein sugar,
Alitame, neotame, the one or more combination of Aspartame.
A kind of preparation method of ion VC granules, comprises the following steps：Vitamine C sodium, fruit powder, essence are added by prescription proportioning
And sweetener, it is well mixed, adds 50% sucrose solution, granule is made in softwood processed, granulation, vacuum freeze drying, whole grain.
A kind of another preparation method of ion VC granules, comprises the following steps：（1）Sucrose, dimension are added by prescription proportioning
Raw element C sodium, acid source, fruit powder and sweetener, are well mixed, add 50% sucrose solution softwood, pelletize, vacuum freeze drying,
Whole grain, is made granulates；
（2）Sucrose, alkali source and essence are added by prescription proportioning, is well mixed, adds 50% sucrose solution softwood, pelletize, very
Alkali particle is made in vacuum freecing-dry, whole grain.
（3）Processing is dried to granulates and alkali particle respectively, afterwards granulates and alkali particle are well mixed, point
Dress, produces effervescence granular.
Acid source is citric acid, tartaric acid, malic acid, the one or more combination of fumaric acid.
Alkali source is any one in carbonic acid hydrogen ion, saleratus, carbonate ions, potassium carbonate.
Embodiment 3
A kind of ion VC granules, prepare 1000g preparations and are made up of the raw material of following weight proportion：600 parts of sucrose, vitamin C
300 parts of sodium, 30 parts of fruit powder, 12 parts of sweetener, 5 parts of essence.
Sweetener be mannitol, lactitol, glucose, sucrose, isomaltoketose, maltitol, trehalose, protein sugar,
Alitame, neotame, the one or more combination of Aspartame.
A kind of preparation method of ion VC granules, comprises the following steps：Vitamine C sodium, fruit powder, essence are added by prescription proportioning
And sweetener, it is well mixed, adds 50% sucrose solution, granule is made in softwood processed, granulation, vacuum freeze drying, whole grain.
A kind of another preparation method of ion VC granules, comprises the following steps：（1）Sucrose, dimension are added by prescription proportioning
Raw element C sodium, acid source, fruit powder and sweetener, are well mixed, add 50% sucrose solution softwood, pelletize, vacuum freeze drying,
Whole grain, is made granulates；
（2）Sucrose, alkali source and essence are added by prescription proportioning, is well mixed, adds 50% sucrose solution softwood, pelletize, very
Alkali particle is made in vacuum freecing-dry, whole grain.
（3）Processing is dried to granulates and alkali particle respectively, afterwards granulates and alkali particle are well mixed, point
Dress, produces effervescence granular.
Acid source is citric acid, tartaric acid, malic acid, the one or more combination of fumaric acid.
Alkali source is any one in carbonic acid hydrogen ion, saleratus, carbonate ions, potassium carbonate.
Embodiment 4
A kind of preparation method of ion VC granules, 500 parts of sucrose, 100 parts of vitamine C sodium, essence 10 are added by prescription proportioning
10 parts of part, 10 parts of fruit powder and mannitol, are well mixed, and add 50% sucrose solution, softwood processed, the granulation of 16 mesh sieves, vacuum refrigeration
Dry, granule is made in 18 mesh sieve whole grains.
Embodiment 5
A kind of preparation method of ion VC granules, 200 parts of sucrose, 400 parts of tartaric acid, vitamine C sodium are added by prescription proportioning
150 parts and 5 parts of neotame, are well mixed, and add 50% sucrose solution, softwood processed, the granulation of 16 mesh sieves, vacuum freeze drying, 18 mesh
Whole grain is sieved, granulates are made；15 parts of 200 parts of sucrose, 600 parts of sodium acid carbonate and essence are well mixed, 50% sucrose is added molten
Alkali particle is made in liquid softwood, 16 mesh sieves granulation, vacuum freeze drying, 18 mesh sieve whole grains.By dried granulates and alkali
Grain is well mixed, packing, produces effervescence granular.
Detailed description above is only the explanation of the preferred embodiments of the invention, non-therefore the limitation present invention the scope of the claims,
So, all equivalence techniques changes with carried out by this creation description,
It is both contained in the scope of the claims of the present invention.
Claims (9)
1. a kind of ion VC granules, it is characterised in that prepare 1000g preparations and be made up of the raw material of following weight proportion：Sucrose
500-700 parts, 100-500 parts of vitamine C sodium, 10-50 parts of fruit powder, 5-20 parts of sweetener, 1-10 parts of essence.
2. a kind of ion VC granules as claimed in claim 1, it is characterised in that prepare 1000g preparations and matched somebody with somebody by following weight
The raw material composition of ratio：500 parts of sucrose, VC500 parts of vitamine C sodium, 10 parts of fruit powder, 20 parts of sweetener, 1 part of essence.
3. a kind of ion VC granules as claimed in claim 1, it is characterised in that prepare 1000g preparations and matched somebody with somebody by following weight
The raw material composition of ratio：700 parts of sucrose, 100 parts of vitamine C sodium, 50 parts of fruit powder, 5 parts of sweetener, 10 parts of essence.
4. a kind of ion VC granules as claimed in claim 1, it is characterised in that prepare 1000g preparations and matched somebody with somebody by following weight
The raw material composition of ratio：600 parts of sucrose, 300 parts of vitamine C sodium, 30 parts of fruit powder, 12 parts of sweetener, 5 parts of essence.
5. a kind of ion VC granules as described in Claims 1-4, it is characterised in that：Described sweetener is mannitol, breast
Sugar alcohol, glucose, sucrose, isomaltoketose, maltitol, trehalose, protein sugar, alitame, neotame, one kind of Aspartame
Or several combinations.
6. the preparation method of a kind of ion VC granules as described in Claims 1-4, it is characterised in that comprise the following steps：
Vitamine C sodium, fruit powder, essence and sweetener are added by prescription proportioning, is well mixed, 50% sucrose solution is added, softwood processed,
Granule is made in granulation, vacuum freeze drying, whole grain.
7. another preparation method of a kind of ion VC granules as described in Claims 1-4, it is characterised in that including as follows
Step：（1）Sucrose, vitamine C sodium, acid source, fruit powder and sweetener are added by prescription proportioning, is well mixed, adds 50% sucrose
Granulates are made in solution softwood, granulation, vacuum freeze drying, whole grain；
（2）Sucrose, alkali source and essence are added by prescription proportioning, is well mixed, adds 50% sucrose solution softwood, pelletize, very
Alkali particle is made in vacuum freecing-dry, whole grain；
（3）Processing is dried to granulates and alkali particle respectively, afterwards granulates and alkali particle are well mixed, dispensed, i.e.,
Obtain effervescence granular.
8. a kind of another preparation method of ion VC granules as claimed in claim 7, it is characterised in that：Described acid source is
Citric acid, tartaric acid, malic acid, the one or more combination of fumaric acid.
9. a kind of another preparation method of ion VC granules as claimed in claim 7, it is characterised in that：Described alkali source is
Any one in carbonic acid hydrogen ion, saleratus, carbonate ions, potassium carbonate.
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| CN1506047A (en) * | 2002-12-06 | 2004-06-23 | 长沙市泰宝制药有限公司 | Effervescent vitamin C granule and its prepn |
| CN102824313A (en) * | 2012-09-18 | 2012-12-19 | 东北制药（沈阳）科技发展有限公司 | Vitamin C effervescent granule and preparation method thereof |
| CN103462002A (en) * | 2013-08-13 | 2013-12-25 | 深圳市麦金利实业有限公司 | Vitamin c effervescent tablet and preparation method thereof |
| CN106420655A (en) * | 2016-10-24 | 2017-02-22 | 广西圣保堂健康产业股份有限公司 | Effervescent tablet containing vitamin C sodium and preparation method of effervescent tablet |
| CN106562438A (en) * | 2016-10-28 | 2017-04-19 | 广西圣保堂健康产业股份有限公司 | Immunity enhancement composition and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1506047A (en) * | 2002-12-06 | 2004-06-23 | 长沙市泰宝制药有限公司 | Effervescent vitamin C granule and its prepn |
| CN102824313A (en) * | 2012-09-18 | 2012-12-19 | 东北制药（沈阳）科技发展有限公司 | Vitamin C effervescent granule and preparation method thereof |
| CN103462002A (en) * | 2013-08-13 | 2013-12-25 | 深圳市麦金利实业有限公司 | Vitamin c effervescent tablet and preparation method thereof |
| CN106420655A (en) * | 2016-10-24 | 2017-02-22 | 广西圣保堂健康产业股份有限公司 | Effervescent tablet containing vitamin C sodium and preparation method of effervescent tablet |
| CN106562438A (en) * | 2016-10-28 | 2017-04-19 | 广西圣保堂健康产业股份有限公司 | Immunity enhancement composition and preparation method thereof |
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Application publication date: 20170922 |