CN101874629A - Total-nutrient multifunctional compound hippophae rhamnoides and natto health-care product - Google Patents
Total-nutrient multifunctional compound hippophae rhamnoides and natto health-care product Download PDFInfo
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- CN101874629A CN101874629A CN2010101799136A CN201010179913A CN101874629A CN 101874629 A CN101874629 A CN 101874629A CN 2010101799136 A CN2010101799136 A CN 2010101799136A CN 201010179913 A CN201010179913 A CN 201010179913A CN 101874629 A CN101874629 A CN 101874629A
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Abstract
The invention discloses a total-nutrient multifunctional compound hippophae rhamnoides and pine pollen health-care product, which is prepared by mixing 20 to 80 weight percent of hippophae rhamnoides, 20 to 80 weight percent of natto, 1 to 15 weight percent of tea polyphenol and 2 to 20 weight percent of resveratrol, wherein the weight percentage ratio of medicaments to auxiliary materials is 20-80 weight percent: 80-20 weight percent. The health-care product can be formed into capsules, tablets, chewable tablet, grains, oral liquid and soft capsules. The product offers remarkable health-care effects through properties of treating cerebral and vascular diseases, endocrinopathy, digestive system diseases and nervous system diseases, preventing and curing cancers, improving immunity, resisting bacteria, diminishing inflammation, resisting oxidization, radiation, osteoporosis and aging, reducing weight, skin beautifying, and the like. The product has an active social and economic significance in terms of disease prevention, body building and industrial promotion realization.
Description
Technical field:
The present invention relates to a kind of multifunctional full-nutritious health products,, belong to the technical field of health food and preparation method thereof more specifically to hippophae rhamnoides and natto compound health products and preparation method thereof.
Background technology:
Sea-buckthorn, natto, Tea Polyphenols, resveratrol are the nutrition elaboration of modern science and technology to finding in the natural product research, and it is abundant all to have chemical composition, and health-care effect is extensive, characteristics such as edible high safety.With the health products that sea-buckthorn, natto, Tea Polyphenols, resveratrol simple produce, kind in the listing product, brand are numerous, have also brought into play useful effect in health care.But along with the raising of people's health care consciousness, the modern pursues be in the nutrition more comprehensively, the health products of " Quicker, Higher and Stronger " on the effect.And the health products that simple is made exist composition dullness, hypotrophy face, health-care efficacy can not be complementary, and short-term effect is outstanding inadequately, the shortcoming that long-term effect is stable inadequately.Obviously it is multi-level to satisfy people, high-level requirements of health care.
Can stop solidifying of blood as Nattokinase solubilized thrombus, pyrazine, but natto the elasticity that improves vascular wall and resistance, softening and protection blood vessel, strengthen capillary intensity, improve blood circulation, prevent and treat artery sclerosis, cardiac and cerebral vascular diseases aspects such as hypertension, cerebral hemorrhage, varication show directly also very not reluctantly; The arsenic diphosphoglyceric acid and the antibacterial peptide that contain in the natto, can effectively kill the pathogenicity Escherichia coli, but at detoxicating intestine, relax bowel, clearing and activating the channels and collaterals, improve a poor appetite, promote to digest and aspects such as absorption function, the functions of intestines and stomach disorder to digestive system, gastritis, ulcer, diarrhoea are renderd a service very littlely, also lack the support of compositions such as sufficient natural active amino acid, organized enzyme, multivitamin, mineral matter.Sea-buckthorn is to be described as " living fossil ", the vitamin that is rich in, mineral matter, unrighted acid, Flavonoid substances etc., the human body blood fat there is regulating action, but softening blood vessel, adjusting cholesterol, the microcirculation that improves heart and brain, prevention cardiovascular and cerebrovascular disease, but solidify with thrombosis powerlessly for lysed blood, the intestines and stomach beneficial bacterium is lacked the support effect.And so on.Therefore say that the comprehensive more single plant of nutritional labeling also has the one side of the weakness of its " side door ", the mystery again the health-care effect of single plant exaggeration also is difficult to realize the expectation target of health care comprehensively.On the other hand, modern science conducts a research to sea-buckthorn, natto, Tea Polyphenols, resveratrol, majority also only rests on the molecular level, and single product research is more, the emphasis of research also is confined to the effect aspect of individual product, and to its drug combination and the mechanism of action thereof, it is rare especially to be seen in the report of document few, such product.
In order to overcome the defective of prior art, the object of the present invention is to provide a kind of nutritional labeling complete, the scope of application is extensive, effect significantly and surmount and promote the hippophae rhamnoides and natto compound formulation of the independent result of use of each composition, adopt sea-buckthorn, natto, Tea Polyphenols, the white compound prescription of black false hellebore, in the hope of reaching the health care target of 1+1＞2, it is multi-level to satisfy people, high-level health care new demand.
The applicant notices, Chinese invention patent number 200810136893.7 " a kind of compound dual-purpose natto capsules as medicine or food and preparation method thereof ", this product are to be the capsule of feedstock production with natto, hawthorn, cassia seed, sea-buckthorn.Hawthorn, cassia seed mainly contain compositions such as flavonoids, Chrysophanol, and the health care scope has limitation.Completely different with this patent product prescription, purposes.Prescription with product of the present invention is a feature, determines multinomial keyword, consults scientific and technical literature, patent documentation and national drug approval document, there is no identical or similar report.
Summary of the invention:
One of the object of the invention: the formula for a product that a kind of total-nutrient multifunctional compound hippophae rhamnoides and natto health-care product is provided.
Two of the object of the invention: the industrialized process for preparing that this product is provided.
Three of the object of the invention: the main application of illustrating this product.
Technical scheme of the present invention is achieved in that
A kind of total-nutrient multifunctional compound hippophae rhamnoides and natto health-care product, it is with sea-buckthorn, natto, Tea Polyphenols, resveratrol is composite to form, and the effect of its compound basis and each composition is:
1, sea-buckthorn: sea-buckthorn all has long medicinal history all over the world.Main chemical compositions contains more than 200 kind of bioactivators such as multivitamin, amino acid, trace element, flavone compound, unrighted acid, alkaloid.Sea buckthorn fruit have the title of " natural complex capsule and pill ", also is rich in trace elementses such as 24 kinds of phosphorus, iron, magnesium, manganese, potassium, calcium, boron, silicon, copper etc., and especially the content with calcium, iron, zinc, potassium, selenium is maximum.Extract hippophae rhamnoides fruit oil, Seabuckthorm Seed Oil are safeguarded cardiovascular and cerebrovascular health, improve immunity, improve neurasthenia, anti-oxidant, anti-ageing, protection liver, promote skin ulcer and wound healing, anti-inflammatory myogenic, promote the effect of digestive function, skin-protecting face nursing.The effect of its core is vitamin and the support of mineral matter physiology that protection is cardiovascular, high-load is provided.
2, natto: natto is the traditional food that originates from China, after reach Japan and now become representative functions food.Natto is the food of producing with soybean and fermentation of bacillus subtilis, and the edible history in more than 1000 year is arranged, and is described as " father of ferment ".Main chemical compositions has Nattokinase, high-quality small protein (polypeptide), hepatocuprein, saponin, natto polysaccharide, isoflavones, linoleic acid, multivitamin and mineral matter.Nutritional labeling and thrombus with multiple physiologically active, anticoagulation, anti-platelet aggregation improves microcirculation, anti-ageing, and health cares such as reducing blood lipid, steady blood sugar, adjusting organism metabolism are worth.The effect of its core is thrombus (effect is better than urokinase), reducing blood lipid, hypotensive.
3, Tea Polyphenols: Tea Polyphenols is in the tealeaves
Catechin,
AcetoneClass, phenolic acid class and
AnthocyanidinThe general name of compounds.Be elite in the green tea, the most useful nutritional labeling.Have anti-oxidant, anti-ageing, strengthen many-sided pharmacological function such as immunity.Be called as since ancient times and control " medicines of ten thousand diseases ".Modern medicine circle is described as the best medicine of elimination free radical of high effect nontoxic " 21 century ", is that China is unique by the prescription medicine of drugs approved by FDA.The effect of its core is balanced in nutrition, effectively activates life vigour.
4, resveratrol: resveratrol (Resveratrol is called for short Res) is 3,5, and 4 '-trihydroxy talan belongs to stilbene compound.Resveratrol is that plant is under adverse circumstances or suffer pathogen when infringement, a kind of antitoxin of plant self secretion.Resveratrol exists in conjunction with two kinds of forms of attitude (Cis formula-trans) with free state (Cis formula-trans) and glucosides, all has anti-oxidant usefulness.Human body is had platelet aggregation-against, regulate content of cholesterol in the blood, antiatherosclerosis, alleviate the sick danger that development takes place of worry; Antitumaous effect all has inhibitory action to generation, enhancement, the expansion three phases of cancer, is another important natural anti-cancer drugs after taxol; Antibacterial action, antibacterial effect and penicillin are suitable; Liver protection function; Anti-aging effects.Recent study finds, resveratrol to nervous system such as Parkinson's, memory, cognitive decrease has significant effect, is again good mood stabilizer simultaneously.Its core effect is that thrombus, antimicrobial antiphlogistic and brain tonic protect brain.
The present invention is sea-buckthorn, natto, Tea Polyphenols, resveratrol organic combination, nutritional labeling complementation, the complementation of core effect, mechanism of action complementation have been realized, remedied functional defect separately, and obtained to mutually promote between the various compositions, mutual restriction, the complementary enhancing and self-regulating function, make better must the adapting of these active materials and compatibility mechanism with the needs of human body.Can be lower than the combination of the independent consumption of each composition, reach the effect that comprehensive effect surmounts and promote the independent use of each composition, enlarge range of application.Products obtained therefrom is to cardio cerebrovascular affection, endocrinopathy, digestive system, nervous system, improves immunity at cancer-resisting, anti-inflammation, anti-oxidant, radioresistance, osteoporosis, delay senility, reducing weight and beautifying features etc. all has significant health-care effect.
Described total-nutrient multifunctional compound hippophae rhamnoides and natto health-care product, sea-buckthorn, natto, the proportion compatibility of Tea Polyphenols, each component of resveratrol (pressing the medicinal powder percentage by weight) sea-buckthorn 20-80%, natto 20-80%, Tea Polyphenols 1-15%, resveratrol 2-20%, surplus is a pharmaceutic adjuvant.
Above-mentioned compound hippophae rhamnoides and natto health-care product, the preferred proportion compatibility of each component (pressing the medicinal powder percentage by weight) is a sea-buckthorn 42%, natto 42%, Tea Polyphenols 6%, resveratrol 10%, surplus is a pharmaceutic adjuvant.
The raw material of described compound hippophae rhamnoides and natto health-care product, sea-buckthorn, natto, Tea Polyphenols, resveratrol will meet food hygienic standard, nutrient prime replenisher, the food additives sanitary standard of Chinese Pharmacopoeia, country or industry.All raw materials all are commercially available.Specifically, sea-buckthorn (main position is a hippophae rhamnoides fruit oil) will meet HB/QS001-1994 hippophae rhamnoides fruit oil People's Republic of China (PRC) industry standard; Natto will meet SB/T10528-2009 natto People's Republic of China (PRC) industry standard; Tea Polyphenols is wanted accord with Q B 2154 food additives Tea Polyphenols standards; Resveratrol is bought the grape skin extract of the mass fraction of resveratrol at 60%-95%, and grape skin extract will have test basis.
The auxiliary material of described compound hippophae rhamnoides and natto health-care product, it is meant pharmaceutic adjuvant and the food additives that added according to the product formulation needs with for the taste, color etc. that improve product.It includes but not limited to microcrystalline cellulose, superfine silica gel powder, carboxymethyl cellulose, hydroxypropyl methylcellulose, sucrose, food oil, dolomol, citric acid, flavoring essence etc.The ratio of medicine and auxiliary material (by weight percentage) is 20-80%: 80-20%, and the ratio (by weight percentage) of preferred medicine and auxiliary material is 40-60%: 60-40%.
The formulation method of described compound hippophae rhamnoides and natto health-care product: with sea-buckthorn, natto, Tea Polyphenols, resveratrol according to the recipe quantity mixing, with auxiliary material or food additives mixing, are made common formulations by known preparation technique again.
The formulation of described compound hippophae rhamnoides and natto health-care product, it includes but not limited to capsule, tablet, chewable tablets, granule, oral liquid, soft capsule etc.
The purposes of described compound hippophae rhamnoides and natto health-care product, it includes but not limited to cardio cerebrovascular affection, endocrinopathy, digestive system, nervous system, cancer-resisting, raising immunity, anti-inflammation, anti-oxidant, radioresistance, osteoporosis, delay senility, reducing weight and beautifying features etc. all has significant health-care effect.
The specific embodiment:
In order to help those skilled in the art more fully to understand the present invention, be described in detail the specific embodiment of the present invention.But the right that cited embodiment does not limit the present invention in any way.
Embodiment 1: the compound hippophae rhamnoides and natto capsule
Prescription is formed: freeze dry powder of fermented soybean 1200g, sea-buckthorn powder 1200g, resveratrol (grape skin extract that contains 60% resveratrol) 270g, Tea Polyphenols 170g, carboxymethyl cellulose 1430g, microcrystalline cellulose 500g, superfine silica gel powder 250g.
Preparation technology: take by weighing each composition by recipe quantity, fully mixing is granulated, drying, and subsequent technique is made 10000 of compound hippophae rhamnoides and natto capsules by known capsule technology.
Embodiment 2: the preparation of compound hippophae rhamnoides and natto chewable tablets
Prescription is formed: freeze dry powder of fermented soybean 120g, sea-buckthorn powder 120g, resveratrol (grape skin extract that contains 60% resveratrol) 27g, Tea Polyphenols 17g, sucrose 126g, microcrystalline cellulose 50g, superfine silica gel powder 25g, citric acid 7g, dolomol 7g.
Preparation technology: each component mixes in will writing out a prescription, and is wetting with 85% ethanol water, crosses the 8-24 mesh sieve and granulates, and 60 ℃ of-70 ℃ of oven dry mix with dolomol again, granulate with the 12-40 mesh sieve, are pressed into 1000 of chewable tablets by the 0.5g mould.
Embodiment 3: the compound hippophae rhamnoides and natto preparation of soft capsule
Prescription is formed: freeze dry powder of fermented soybean 120g, sea-buckthorn powder 120g, resveratrol (grape skin extract that contains 60% resveratrol) 27g, Tea Polyphenols 17g, salad oil 216g.
Preparation technology:
1, take by weighing above-mentioned each component dry powder by recipe quantity and stir, to wherein adding salad oil, stirring and dissolving obtains mixed liquor, heats 50 ℃ of 30min, refilters, leaves standstill froth breaking, gets capsulation solution.
2, choose an amount of gelatin and soak imbibition through pure water, fusion is stirred in soak heating (60 ℃ of 100min), filters insulation, filtered fluid deaeration, is incubated and leaves standstill, and promptly gets the softgel shell glue.
3, softgel shell glue and capsulation solution obtain wet ball through rotation embrane method pellet processing machine pill, are dried to dried ball through 50 ℃ then, get product through polishing,
Embodiment 4: the health-care effect experiment of compound hippophae rhamnoides and natto soft capsule
Be positioned at " and colleague " health products Co., Ltd in Huanggu District The Northern Imperial Tomb street, Shenyang City, health-care effect experiment from beginning in May, 2009 tissue " compound hippophae rhamnoides and natto soft capsule " experimenter group, experimenter group reaches 98000 people, experimenter's oral administered compound every day hippophae rhamnoides and natto soft capsule 6-9 grain divides and takes for 2-3 time.Respectively laggard line trace survey in 90 days, 150 days, 68% experimenter has positive health-care effect in 30 days taking this product, and 95% people is in taking this product 90 days, and coronary heart disease, insomnia, gastrointestinal disease have significant improvement; Wherein 138 patients with severe symptoms were taking the compound hippophae rhamnoides and natto soft capsule 120 days, and the state of an illness has remarkable improvement.The compound hippophae rhamnoides and natto soft capsule is subjected to experimenter group's general favorable comment.
Claims (8)
1. total-nutrient multifunctional compound hippophae rhamnoides and natto health-care product, it is characterized in that: it is with sea-buckthorn, natto, Tea Polyphenols, resveratrol is composite to form, the proportion compatibility of each component (pressing the medicinal powder percentage by weight) sea-buckthorn 20-80%, natto 20-80%, Tea Polyphenols 1-15%, resveratrol 2-20%, surplus is a pharmaceutic adjuvant.
2. according to the preferred proportion compatibility of each component of the described compound hippophae rhamnoides and natto health-care product of claim 1, it is characterized in that: the preferred proportion compatibility of each component (pressing the medicinal powder percentage by weight) is sea-buckthorn 42%, natto 42%, Tea Polyphenols 6%, resveratrol 10%, surplus are pharmaceutic adjuvant.
3. according to the raw material of claim 1,2 described compound hippophae rhamnoides and natto health-care products, it is characterized in that: raw materials used food hygienic standard, nutrient prime replenisher sanitary standard, the food additives sanitary standard that will meet Chinese Pharmacopoeia, country or industry.
4. according to the auxiliary material of claim 1,2 described compound hippophae rhamnoides and natto health-care products, it is characterized in that: it is meant pharmaceutic adjuvant and the food additives that added according to the product formulation needs with for the taste, color etc. that improve product, and it includes but not limited to microcrystalline cellulose, superfine silica gel powder, carboxymethyl cellulose, hydroxypropyl methylcellulose, sucrose, food oil, dolomol, citric acid, flavoring essence.
5. according to the ratio of claim 1,2 described compound hippophae rhamnoides and natto health-care product medicines and auxiliary material, it is characterized in that: the ratio of medicine and auxiliary material (by weight percentage) is 20-80%: 80-20%, and the ratio (by weight percentage) of preferred medicine and auxiliary material is 40-60%: 60-40%.
6. according to the formulation method of claim 1,2 described compound hippophae rhamnoides and natto health-care products: it is characterized in that: with sea-buckthorn, natto, Tea Polyphenols, resveratrol, according to the recipe quantity mixing, with pharmaceutic adjuvant or food additives mixing, make common formulations again by known preparation technique.
7. according to the formulation of claim 1,2 described compound hippophae rhamnoides and natto health-care products, it is characterized in that: it includes but not limited to capsule, tablet, chewable tablets, granule, oral liquid, soft capsule.
8. according to the purposes of claim 1,2 described compound hippophae rhamnoides and natto health-care products, it is characterized in that: it includes but not limited to cardio cerebrovascular affection, endocrinopathy, digestive system, nervous system, cancer-resisting, raising immunity, anti-inflammation, anti-oxidant, radioresistance, osteoporosis, delay senility, reducing weight and beautifying features etc. all has significant health-care effect.
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| CN104799286A (en) * | 2015-04-30 | 2015-07-29 | 南京中生生物科技有限公司 | Composition for improving immunity and preparation method of composition |
| CN107041865A (en) * | 2016-02-05 | 2017-08-15 | 重庆井谷元食品科技有限公司 | A kind of natto particle with beauty functions and preparation method thereof |
| CN107373636A (en) * | 2017-07-21 | 2017-11-24 | 安康世茂生物科技有限公司 | A kind of health products of cancer-resisting |
| JP2019118341A (en) * | 2017-12-28 | 2019-07-22 | 小林製薬株式会社 | Food product containing polyphenol |
| CN110089760A (en) * | 2019-05-07 | 2019-08-06 | 朱国强 | A kind of processing technology of the Combizym of Nattokinase containing active earthworm protein food |
| CN110089758A (en) * | 2019-05-07 | 2019-08-06 | 朱国强 | One kind Combizym food of Nattokinase containing active earthworm protein and preparation method thereof |
| CN110089759A (en) * | 2019-05-07 | 2019-08-06 | 朱国强 | A kind of Combizym food eaten suitable for Patients with Cardiovascular/Cerebrovascular Diseases |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104799286A (en) * | 2015-04-30 | 2015-07-29 | 南京中生生物科技有限公司 | Composition for improving immunity and preparation method of composition |
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| CN107041865A (en) * | 2016-02-05 | 2017-08-15 | 重庆井谷元食品科技有限公司 | A kind of natto particle with beauty functions and preparation method thereof |
| CN107373636A (en) * | 2017-07-21 | 2017-11-24 | 安康世茂生物科技有限公司 | A kind of health products of cancer-resisting |
| JP2019118341A (en) * | 2017-12-28 | 2019-07-22 | 小林製薬株式会社 | Food product containing polyphenol |
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| CN110089760A (en) * | 2019-05-07 | 2019-08-06 | 朱国强 | A kind of processing technology of the Combizym of Nattokinase containing active earthworm protein food |
| CN110089758A (en) * | 2019-05-07 | 2019-08-06 | 朱国强 | One kind Combizym food of Nattokinase containing active earthworm protein and preparation method thereof |
| CN110089759A (en) * | 2019-05-07 | 2019-08-06 | 朱国强 | A kind of Combizym food eaten suitable for Patients with Cardiovascular/Cerebrovascular Diseases |
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Application publication date: 20101103 |