KR101408814B1 - Korean medicinal tea and health functional food having strong antioxidant activity and high acceptabilitythe - Google Patents
Korean medicinal tea and health functional food having strong antioxidant activity and high acceptabilitythe Download PDFInfo
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- KR101408814B1 KR101408814B1 KR1020120146024A KR20120146024A KR101408814B1 KR 101408814 B1 KR101408814 B1 KR 101408814B1 KR 1020120146024 A KR1020120146024 A KR 1020120146024A KR 20120146024 A KR20120146024 A KR 20120146024A KR 101408814 B1 KR101408814 B1 KR 101408814B1
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
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- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/16—Tea extraction; Tea extracts; Treating tea extract; Making instant tea
- A23F3/30—Further treatment of dried tea extract; Preparations produced thereby, e.g. instant tea
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A23L2/39—Dry compositions
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/40—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by drying or kilning; Subsequent reconstitution
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/40—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by drying or kilning; Subsequent reconstitution
- A23L3/46—Spray-drying
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2300/00—Processes
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Landscapes
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- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
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- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Botany (AREA)
- Mycology (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
본 발명은 항산화능이 우수할 뿐만 아니라, 관능성이 우수하여 한약에 대해 거부감을 나타내는 청소년, 여성 및 일반인들이 부담감 없이 마실 수 있는 한방차 및 건강 기능 식품에 관한 것으로서, 보다 상세하게는 오랫동안 비방으로 내려온 21종의 원기회복용 복방 한방 약제를 고온에서 열수 추출하고, 이를 통상의 방법으로 필터한 후, 감압 분무건조 또는 동결건조하여 분말로 제조하고, 여기에 말토덱스트린, 정백당, 자일리톨, 구연산 등을 혼합하여 한방차 및 건강 기능 식품으로 제조하는 기술에 관한 것이다. The present invention relates to a herbal tea and a health functional food which are excellent not only in antioxidant ability but also in sensory properties and which can be consumed by the adolescents, women and ordinary people who feel resistance to herbal medicine without any burden. More particularly, Twenty-one kinds of herbal medicine for femoral hereditary feces were hot-water-extracted at a high temperature, filtered by a usual method, and then subjected to vacuum spray drying or freeze-drying to prepare powders. Maltodextrin, black sugar, xylitol, And to a technology for manufacturing a herbal tea and a health functional food.
현대사회는 산업화로 인한 생활수준의 향상과, 라이프스타일의 변화로 전통적인 식생활이 위협받고 있으며, 이러한 식생활 변화에 따라, 비만, 고혈압, 고지혈증 등의 다양한 성인병이 급증하고 있는 실정이다. 이러한 문제점을 극복하고자 다양한 건강지향성 제품들이 개발되고 있으며, 근래에는 한방재료를 이용한 약선식품에 대한 수요가 매우 높으며, 특히 간편하게 언제 어디서라도 음용할 수 있는 약선 한방차에 대한 관심이 급증하고 있는 실정이다. Modern society is threatened by the improvement of living standard due to industrialization and lifestyle change, and dietary changes are changing, and various adult diseases such as obesity, hypertension and hyperlipidemia are increasing rapidly due to such dietary changes. In order to overcome these problems, various health-oriented products have been developed. In recent years, there has been a great demand for medicinal foods using herbal ingredients, and there has been a growing interest in medicinal herbal tea which is easy to drink anytime and anywhere .
일반적으로 한약은 한의학의 기본 이론을 바탕으로 질병의 예방이나, 치료를 위해 천연물 또는 가공된 약제를 혼합 조제한 약물을 의미하며, 다양한 동물, 식물, 광물의 추출물을 추출하여 사용하나 대부분은 약용 식물을 사용하고 있다. 각각의 한약재 추출물은 각각 특유한 고도의 생리활성을 나타내는 데, 그 예로서 특정 조성의 한약 조성물이 항암 활성, 항당뇨 활성, 동맥경화 예방활성, 면역기능 증강활성, 숙취 해소 활성, 뇌졸중 예방 및 아토피 치료 활성 등을 나타냄이 알려져 있다. Generally, Chinese medicine refers to a medicine prepared by mixing natural or processed medicines for the prevention and treatment of diseases based on the basic theory of Oriental medicine. Extracts of various animals, plants and minerals are extracted and used, but most of them are medicinal plants I am using it. Each of herbal medicinal plant extracts exhibits a unique high level of physiological activity, for example, a herbal composition of a specific composition has anticancer activity, antidiabetic activity, arteriosclerosis prevention activity, immune function enhancing activity, hangover elimination activity, stroke prevention, Activity and the like are known.
현재까지, 대한민국 등록특허에는 암치료와 암예방을 위한 한약 조성물(제 10-0671762호, 2007년 1월 15일), 당뇨병 및 이로 인한 합병증 치료 및 예방용 한약 조성물(제 10-0712659호, 2007년 4월 23일), 반하, 백출, 천마, 진피, 복령, 산사, 희렴 및 황련을 포함하는 한약 제제 혼합물의 동맥경화 및 관련 질환의 예방 및 치료용 추출물과, 이를 유효성분으로 함유하는 동맥경화 및 관련 질환의 예방 및 치료용 약학 조성물(제 10-0787174호, 2007년 12월 12일), 루푸스 치료용 한약 추출물(제 10-0682046호, 2007년 2월 6일), 숙취 해소용 한약 조성물 및 이를 함유하는 음료(제 10-1176590호, 2012년 8월 17일), 뇌졸중과 치매를 포함하는 퇴행성 뇌질환의 예방과 치료용 건강 기능성 식품 및 약제학적 조성물(제 10-0950164호, 2010년 3월 23일), 아토피 피부염 개선능을 갖는 화장료 조성물 및 이의 사용방법(제 10-1183893호, 2012년 9월 12일) 등이 다양한 한방 제제를 이용한 기능성 제품 개발로 개시되어 있다. 최근에는 한약재의 추출 기술이 발전되고, 각종 제형 기술이 발달되면서, 한약재의 약효가 향상되고, 휴대가 용이하며, 기호성이 강화된 한약 관련 제품이 개발되어 한약의 대중화 및 보급에 기여하고 있다. 그 예로서, 농축된 한약 추출물을 포함하는 초콜렛의 제조방법(제 10-0812826호, 2008년 3월 5일) 및 초콜릿 한약 및 가나슈 초콜릿 한약(제 10-0769699호, 2007년 10월 17일)이 알려져 있다. Heretofore, the Korean registered patent includes a herbal composition for cancer treatment and cancer prevention (No. 10-0671762, January 15, 2007), a herbal composition for treating and preventing diabetes and its complications (No. 10-0712659, 2007 Extracts for the prevention and treatment of arteriosclerosis and related diseases of herbal medicine preparations including antimicrobial agents, antioxidants, antioxidants, antioxidants, antioxidants, antioxidants, antioxidants, antioxidants, antioxidants, antioxidants, And a medicinal composition for prevention and treatment of related diseases (Korean Patent No. 10-0787174, December 12, 2007), herbal medicine extract for treating lupus (Korean Patent No. 10-0682046, February 6, 2007) (10-1176590, August 17, 2012), health functional food and pharmaceutical compositions for the prevention and treatment of degenerative brain diseases including stroke and dementia (10-0950164, 2010 March 23), a cosmetic composition having atopic dermatitis-improving ability and (No. 10-1183893, September 12, 2012) have been disclosed in the development of functional products using various herbal preparations. In recent years, as the extraction technology of herbal medicines has been developed and various formulation techniques have been developed, the medicinal properties of herbal medicines have been improved, easy to carry and palatability have been developed, and herbal medicines related products have been developed and popularized. Examples thereof include a process for producing chocolate containing concentrated herbal extracts (No. 10-0812826, Mar. 5, 2008) and chocolate herbal medicine and Ganache chocolate herbal medicine (No. 10-0769699, October 17, 2007) Is known.
한편, 우리나라는 전통적으로 차를 음료 혹은 약으로 사용하여 왔으며, 차 문화는 종교, 정치, 경제적 여건에 크게 좌우된다. 과거 차류는 고소득층의 기호식품으로 한정되었으나, 최근에는 일상생활의 필수 식품으로 자리잡고 있으며, 건강기능성의 한방 약선차는 일반적인 차류, 다류 시장에 비해 기술적인 진입장벽이 높아 업체 경쟁이 상대적으로 낮은 편이다. On the other hand, Korea has traditionally used tea as a drink or medicine, and tea culture is highly dependent on religion, politics, and economic conditions. In the past, tea was limited to high-income foods, but it has recently become an indispensable food for everyday life. In contrast, the health-functional herbal medicine car has a relatively low technological barriers .
현재 한차를 비롯한 다양한 한차 등이 개발되어 있으며, 쌍화탕 및 십전대보탕 등이 알려져 있으나, 쓰고 신맛이 강하여 관능성이 낮아 소비자 선호도가 낮으며, 또한 쌍화탕 및 대보탕의 경우 액상으로 판매되어 휴대 및 음용이 어려운 단점이 있다. At present, a variety of one-car types including one-car have been developed, and Ssanghwangtang and Daejwonbotanbang are known. However, they are low in sensuality due to strong writing and sour taste, and they are low in consumer preference. There are disadvantages.
본 발명은 상기와 같은 기존 한방 약선차의 낮은 관능성과 휴대 및 음용의 어려움을 해결하기 위하여 안출된 것으로서, 본 발명에서 해결하고자 하는 과제는 본 발명의 한약재 성분의 유용 생리기능을 최대화하면서도, 남녀노소 누구나 쉽게 마실수 있는 관능성, 기호성이 높은 한방차 제조방법을 제공하며, 또한 이를 동결건조 및 분무건조를 통해 휴대가 간편하면서도, 언제든지 더운물에 녹여 음용이 용이한 분말스틱 포장제품을 제공하고자 하는 것이다.Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made to solve the above problems occurring in the prior art, and it is an object of the present invention to provide a medicinal herb composition which maximizes useful physiological functions of the herbal medicinal ingredient of the present invention, The present invention provides a method of manufacturing a herbal tea having high sensibility and palatability that anyone can easily drink, and it is intended to provide a powdered stick product which is easy to carry through freeze-drying and spray-drying, and which is always melted in hot water to be easily consumed.
상기와 같은 과제를 해결하기 위하여, 본 발명은 백작약, 당귀, 숙지황, 천궁, 황기, 감초, 인삼, 백복신, 산조인, 대추, 산수유, 산약, 구기자, 오미자, 용안육, 내복자, 맥문동, 원지, 황금, 사인 및 산사육의 열수 추출물을 포함하고, 항산화능을 갖는 것을 특징으로 하는 한약재 조성물을 제공한다.In order to solve the above-mentioned problems, the present invention provides a method for producing a ginseng extract, which comprises the steps of: extracting a ginseng extract, Angelica keiskei keiskei, Koryo ginseng, Astragalus korea, Hwanggi ginseng, Licorice ginseng, White ginseng, , A hot water extract of sausage and wild goose, and has antioxidant ability.
상기 열수 추출물은 브릭스가 7.5~8.5, pH가 5.5~6.0 및 고형분 함량이 5~15중량%인 상태에서 열수 추출을 완료하여 열수 추출액을 얻고, 상기 열수 추출액을 동결건조 또는 감압분무건조시켜 제조되는 것이 바람직하다.The hot-water extract is prepared by subjecting the hot-water extract to a hot-water-extracting operation in the state that the brick is in the range of 7.5 to 8.5, the pH is in the range of 5.5 to 6.0 and the solid content is in the range of 5 to 15 wt%, and the hot-water extract is lyophilized or reduced- .
또한, 본 발명은 본 발명의 상기 한약재 조성물을 포함하는 것을 특징으로 하는 한방 약선차를 제공한다.The present invention also provides a herbal medicine composition comprising the herbal composition of the present invention.
상기 한방 약선차는 상기 한약재 조성물 100중량부에 대하여, 말토덱스트린 10~30중량부, 정백당 40~60중량부, 자일리톨 10~20중량부 및 구연산 0.1~2.0중량부를 포함하는 것이 바람직하다.Preferably, the herbal medicine composition comprises 10 to 30 parts by weight of maltodextrin, 40 to 60 parts by weight of xylitol, 10 to 20 parts by weight of xylitol and 0.1 to 2.0 parts by weight of citric acid based on 100 parts by weight of the herbal composition.
또한, 본 발명은 본 발명의 상기 한약재 조성물을 포함하고 항산화능을 갖는 것을 특징으로 하는 건강 기능 식품을 제공한다.The present invention also provides a health functional food comprising the herbal composition of the present invention and having an antioxidant ability.
본 발명의 21종의 한약재로부터 열수 추출된 한약재 조성물은 기존의 7~10종의 한약재를 추출한 쌍화탕 및 십전대보탕 등의 액상 제품보다 우수한 항산화 활성과 항세균 활성을 나타내며, 특히 마음을 편안하게 해주는 뛰어난 효과가 있다. 또한, 본 발명의 한약재 조성물을 포함하는 분말 스틱 제품은 휴대 및 음용이 간편하면서도 새콤달콤한 맛이 강화되어 관능성이 우수하며, 한약에 거부감이 있는 청소년 및 젊은 여성에게도 높은 기호성을 나타내어 고기능성, 고관능성 한방차를 제공하는 효과가 있다.The herbal medicine composition extracted from the 21 kinds of medicinal herbs of the present invention shows superior antioxidative and antibacterial activities than the liquid products such as the ssahwangtang and the sulbajinbotang which are extracted from the existing 7 ~ 10 kinds of medicinal herbs, It is effective. In addition, the powder stick product containing the herbal composition composition of the present invention is easy to carry and drink, and is enhanced in sweet and sour taste, and thus has excellent sensibility. Also, it has high palatability for juveniles and young women who have resistance to herbal medicine, There is an effect of providing a one-pot tea.
이하, 본 발명을 상세하게 설명한다.Hereinafter, the present invention will be described in detail.
본 발명은 한약에 대해 거부감을 나타내는 청소년, 여성 및 일반인들이 부담감 없이 마실 수 있는 관능성이 우수한 한방차 및 건강 기능 식품에 관한 것으로서, 본 발명의 한방차 및 건강 기능 식품은 우수한 항산화 활성과 항세균 활성, 특히 마음을 편안하게 하는 효과가 탁월하다. The present invention relates to a herbal tea and a health functional food which are excellent in sensuality to drink by the adolescents, women and ordinary people who show resistance to herbal medicine without any burdens. The herbal tea and the health functional food of the present invention have excellent antioxidative activity, It is active, especially the effect that comforts the mind.
본 발명의 발명자들은 오랫동안 비방으로 내려온 원기회복용 복방 한방 약제인 백작약, 당귀, 숙지황, 천궁, 황기, 감초, 인삼, 백복신(백복령), 산조인(산대추), 대추, 산수유, 산약, 구기자, 오미자, 용안육, 내복자, 맥문동, 원지, 황금, 사인, 산사육(산사자)의 총 21종의 한약재를 열수 추출하고, 이 추출액을 통상의 방법으로 필터한 후, 감압 분무건조 또는 동결건조하여 분말화한 다음, 말토덱스트린, 정백당, 자일리톨, 구연산 등을 첨가혼합하여 분말 스틱제품으로 제조하였다. The inventors of the present invention have found out that the inventors of the present invention have found that the herbal medicine used for a long time in the slander, , 21 kinds of medicinal herbs (total of 21 kinds of medicinal herbs such as yongcheng, underwear, mokmundong, raw paper, gold, sign, and mountain horsetail) were extracted by hot water extraction and the extract was filtered by a usual method and then powdered by vacuum spray drying or freeze drying Next, maltodextrin, white sugar, xylitol, citric acid and the like were added and mixed to prepare a powder stick product.
상기와 같이 제조된 한약재 조성물의 유용성분, 항산화 활성, 항균활성, 항혈전활성을 시판 K사의 쌍화탕과 비교한 결과, 시판제품보다 2~3배 높은 총폴리페놀 및 총플라보노이드 함량을 나타내었으며, 우수한 항산화 및 항균 활성을 나타내었다. 또한, 다양한 방법으로 건조분말을 제조하여 비교한 결과, 동결건조 및 감압분무건조에서 우수한 물성을 나타내었으며, 최종적으로 관능성을 증대시킬 수 있는 부재료 첨가물의 종류와 첨가량을 결정하여 본 발명의 한약재 조성물을 포함하는 한방차를 제조하였다. 제조된 분말스틱 제품은 기호성이 높으며, 관능성이 우수하였으며, 인간 적혈구에 대한 용혈활성이 전혀 나타나지 않아는 인체 독성이 없음을 확인함으로써 본 발명을 완성하였다. The antioxidant activity, antimicrobial activity, and antithrombotic activity of the medicinal herb composition prepared as described above were compared with those of the commercial S company, and the total polyphenol and total flavonoid contents were 2 to 3 times higher than those of commercial products, Antioxidant and antimicrobial activity. In addition, as a result of comparing and preparing dry powders by various methods, it was found that the kind and amount of additives of the present invention were excellent in freeze drying and reduced pressure spray drying, and finally, Were prepared. The powder stick product thus produced was highly palatable and excellent in sensory properties and confirmed that there was no human toxicity when no hemolytic activity against human erythrocytes was observed. Thus, the present invention was completed.
따라서, 본 발명은 백작약, 당귀, 숙지황, 천궁, 황기, 감초, 인삼, 백복신, 산조인, 대추, 산수유, 산약, 구기자, 오미자, 용안육, 내복자, 맥문동, 원지, 황금, 사인 및 산사육의 열수 추출물을 포함하고, 항산화능을 갖는 것을 특징으로 하는 한약재 조성물을 제공한다.Therefore, the present invention relates to a method for the production of hot water extracts of red ginseng extract, Angelica gigas Nakai, Seokriwoong, Gyungsu, Hwanggi, Licorice, Ginseng, Leptospira, Sanjino, Jujube, Sansui, And has an antioxidant ability.
상기 열수 추출물은 브릭스가 7.5~8.5, pH가 5.5~6.0 및 고형분 함량이 5~15중량%인 상태에서 열수 추출을 완료하여 열수 추출액을 얻고, 상기 열수 추출액을 동결건조 또는 감압분무건조시켜 제조되는 것이 바람직하다.The hot-water extract is prepared by subjecting the hot-water extract to a hot-water-extracting operation in the state that the brick is in the range of 7.5 to 8.5, the pH is in the range of 5.5 to 6.0 and the solid content is in the range of 5 to 15 wt%, and the hot-water extract is lyophilized or reduced- .
또한, 본 발명은 본 발명의 상기 한약재 조성물을 포함하는 것을 특징으로 하는 한방 약선차를 제공한다.The present invention also provides a herbal medicine composition comprising the herbal composition of the present invention.
상기 한방 약선차는 상기 한약재 조성물 100중량부에 대하여, 말토덱스트린 10~30중량부, 정백당 40~60중량부, 자일리톨 10~20중량부 및 구연산 0.1~2.0중량부를 포함하는 것이 바람직하다.Preferably, the herbal medicine composition comprises 10 to 30 parts by weight of maltodextrin, 40 to 60 parts by weight of xylitol, 10 to 20 parts by weight of xylitol and 0.1 to 2.0 parts by weight of citric acid based on 100 parts by weight of the herbal composition.
또한, 본 발명은 본 발명의 상기 한약재 조성물을 포함하고 항산화능을 갖는 것을 특징으로 하는 건강 기능 식품을 제공한다.The present invention also provides a health functional food comprising the herbal composition of the present invention and having an antioxidant ability.
이하에서는, 본 발명의 한약재 조성물과 이를 포함하는 한방차 및 건강 기능 식품의 제조 방법 및 효능 실험 등을 보다 구체적으로 설명한다.Hereinafter, the herbal composition composition of the present invention, the herbal medicine containing the herbal composition and the method for producing the health functional food and the efficacy experiment will be described in more detail.
본 발명은 21종의 한약재로부터 본 발명의 한약재 조성물을 조제하는 단계; 조제된 한약재 조성물을 동결건조 또는 감압 분무건조하여 건조분말을 조제하는 단계; 상기 건조분말에 관능성을 증대시킬 수 있는 부재료를 첨가, 혼합하여 최종 분말스틱 제품을 생산하는 단계; 및 한약재 조성물 및 최종제품의 유용성분 분석, 유용 기능성 평가 및 급성 독성검사단계를 포함한다.The present invention relates to a method for preparing a medicinal herb composition comprising the steps of: preparing a medicinal herb composition of the present invention from 21 medicinal herbs; Preparing a dry powder by freeze-drying or vacuum-spray drying the prepared herbal composition; Adding a raw material capable of enhancing the functionality to the dry powder and mixing to produce a final powdered stick product; And analysis of useful components of herbal composition compositions and final products, useful functional evaluation, and acute toxicity testing.
본 발명의 한약재 조성물에 포함되는 한약재는 표 1과 같으며, 각각을 이용한 다양한 제품 개발(표 2)은 이루어진바 있으나, 21종의 복방 한방 약선차는 개발된 바 없다. The herbal medicines contained in the medicinal herb composition of the present invention are shown in Table 1, and various products using the medicinal herbs have been developed (Table 2). However, 21 kinds of herbal medicines have not been developed.
10-2005-0067482호10-0286534
10-2005-0067482
10-0726006호10-0749233
10-0726006
을 건조·증숙 가공 한 것Rhinoceros rhizome
Dried or mixed
10-0741488호10-0261463
10-0741488
10-2008-0005192호10-0587179
10-2008-0005192
10-0422214호
10-2000-0009250호No. 10-0526404
No. 10-0422214
10-2000-0009250
10-0177832호10-0787633
10-0177832
10-2004-0067921호10-2003-0016557
10-2004-0067921
10-0936455호10-0846738
10-0936455
10-0763620호10-1071154
10-0763620
10-2007-0116402호
10-2007-0140507호10-1995-0013133
10-2007-0116402
10-2007-0140507
10-0428251호10-0883211
10-0428251
10-0990669호10-1120670
10-0990669
10-0371689호
10-1993-0028544호10-0843357
10-0371689
10-1993-0028544
10-0055510호
10-0604492호10-0542876
10-0055510
10-0604492
10-1041044호10-0524385
10-1041044
10-0635440호No. 10-0449245
10-0635440
10-1019892호10-0830186
10-1019892
10-0516180호No. 10-0570120
10-0516180
대한민국 등록특허 제10-0846738호 항산화효과와 피부세포보호효과를 갖는 복령 추출물과 그 추출 물의 제조방법 및 이를 포함하는 화장료 조성물
대한민국 등록특허 제10-0936455호 백복령 추출물과 알칼리 이온수를 이용한 음료의 제조방법
대한민국 등록특허 제10-1189191호 용안육 추출물 또는 이를 포함하는 혼합 추출물을 함유하는 퇴 행성 뇌신경질환의 예방 또는 치료용 조성물
대한민국 등록특허 제10-0830186호 황금 정제 추출물, 이의 제조 방법 및 이를 유효성분으로 함유 하는 간 보호 및 간경변증 예방 및 치료용 조성물
대한민국 등록특허 제10-1019892호 황금된장 제조방법 및 그에 의하여 제조되는 황금된장
대한민국 등록특허 제10-0570120호 산사자 추출물을 함유하는 자유라디칼 소거용 화장료
대한민국 등록특허 제10-0516180호 항고지혈증 조성물
대한민국 특허출원 제10-1995-0013133호 대추차의 제조방법
대한민국 특허출원 제10-2007-0116402호 대추버섯 침출 차 조성물과 그 제조방법
대한민국 특허출원 제10-2007-0140507호 유산균, 효모 혼합발효 대추잎차
대한민국 등록특허 제10-0843357호 구기자 기름의 제조방법 및 이의 방법으로 제조된 구기자기름
대한민국 등록특허 제10-0371689호 구기자를 함유하는 차의 제조방법
대한민국 특허출원 제10-1993-0028544호 분말 구기자차의 제조방법
대한민국 등록특허 제10-0542876호 오미자 추출물을 유효성분으로 함유하는 관절염 예방 및치료용 조성물
대한민국 등록특허 제10-0055510호 오미자 차의 제조 방법
대한민국 등록특허 제10-0604492호 생과즙을 이용한 오미자차 제조방법
대한민국 등록특허 제10-0526404호 황기 추출물을 포함하는 뇌허혈성 신경세포손상 방지용조성물
대한민국 등록특허 제10-0422214호 생약성분을 함유하는 비만방지 차 조성물
대한민국 특허출원 제10-2000-0009250호 8가지의 한약재료를 이용한 한방차
대한민국 등록특허 제10-0787633호 간 기능 개선과 숙취해소용 차 및 그 제조방법
대한민국 등록특허 제10-0177832호 감초 추출물을 사용한 조성물
대한민국 등록특허 제10-0749233호 참당귀 추출물의 제조방법 및 그 조성물
대한민국 등록특허 제10-0726006호 참당귀 유래 다당류를 유효성분으로 포함하는 암질환 전이 억제용 약학적 조성물
대한민국 등록특허 제10-0587179호 항고혈압 기능을 가지는 천궁 추출물
대한민국 특허출원 제10-2008-0005192호 차 조성물 및 그 제조 방법
대한민국 등록특허 제10-0286534호 노화지연용 항산화 차 (작약)
대한민국 특허출원 제10-2005-0067482호 차 조성물 (작약)
대한민국 등록특허 제10-0261463호 십전대보탕 원료를 이용한 과립 대보차의 제조방법 (숙지황)
대한민국 등록특허 제10-0741488호 티백용 한차의 제조방법
대한민국 특허출원 제10-2004-0067921호 가압발포에 의한 무가당 바이오홍삼, 인삼 침출차
대한민국 특허출원 제10-2003-0016557호 당뇨환자가 사용하는 바이오 홍삼 침출 차 조성물 및 그 제조방법
대한민국 등록특허 제10-1071154호 산조인 추출물을 포함하는 항 스트레스 조성물 및 이의 제조방법
대한민국 등록특허 제10-0763620호 산조인 추출물 또는 베툴린산을 유효성분으로 함유하는 성장호르몬 분비촉진용 조성물
대한민국 등록특허 제10-0883211호 산수유를 이용한 건강보조식품의 제조방법
대한민국 등록특허 제10-0428251호 산수유를 이용한 전통 약주의 제조방법과 이의 방법으로 제조한 산수유 약주
대한민국 등록특허 제10-1120670호 산약 발효물을 포함하는 혈류 개선용 조성물, 이의 제조 방법 및 이를 포함하는 건강기능식품
대한민국 등록특허 제10-0990669호 산약 발효주 및 그의 제조방법
대한민국 등록특허 제10-0524385호 용안육, 산조인, 원지 및 백복신의 추출물을 함유한 기억력 증진 및 청소년기 학습능력 개선용 조성물
대한민국 등록특허 제10-1041044호 불면 증상의 예방 및 개선용 조성물과 그의 제조방법
대한민국 등록특허 제10-0449245호 맥문동 추출물을 포함하는 신경성 질환 치료용 조성물
대한민국 등록특허 제10-0635440호 맥문동 추출물을 포함하는 뇌세포 보호 및 기억력 증진용조성물Korean Patent No. 10-0367261 A method of manufacturing a health food for hangover,
Korean Patent Registration No. 10-0846738 Claims: 1. A method for producing an extract of Bombyx mori extract having an antioxidative effect and a skin cell protecting effect, and a cosmetic composition containing the extract
Korean Patent No. 10-0936455 A method for producing beverage using extract of Baekbok-ri and alkaline ionized water
Korean Patent No. 10-1189191 A composition for preventing or treating a progressive brain disease comprising an extract of pancreatic cancer or a mixed extract containing the same
Korean Patent No. 10-0830186: Golden refined extract, a method for producing the same, and a composition for preventing and treating liver and cirrhosis of the liver containing the same as an active ingredient
Korean Patent No. 10-1019892 Production method of golden miso and golden miso produced thereby
Korean Patent No. 10-0570120 Cosmetic for free radical scavenging containing sansa extract
Korean Patent No. 10-0516180
Korean Patent Application No. 10-1995-0013133 A method for producing a jujube tea
Korean Patent Application No. 10-2007-0116402 A composition for leaching tea jujube mushroom and a method for producing the same
Korean Patent Application No. 10-2007-0140507 Lactobacillus, Yeast Mixed Fermented Jujube Leaf
Korean Patent No. 10-0843357 A process for producing gugija oil and gugija oil produced by the process
Korean Patent No. 10-0371689 A method of manufacturing a tea containing gugija
Korean Patent Application No. 10-1993-0028544 Method for producing powdered gugija tea
Korean Patent No. 10-0542876 A composition for preventing and treating arthritis containing an extract of Omija as an active ingredient
Korean Patent No. 10-0055510 A method for manufacturing omiza tea
Korean Patent No. 10-0604492 Method for manufacturing omija tea using raw juice
Korea Patent No. 10-0526404 A composition for inhibiting brain ischemic neuronal damage comprising extracts from Hwanggi
Korean Patent No. 10-0422214 An anti-obesity tea composition containing a herbal medicine ingredient
Korean Patent Application No. 10-2000-0009250 A herbal tea using 8 kinds of herbal medicine materials
Korean Patent No. 10-0787633 Improving liver function and hunting small tea and manufacturing method thereof
Korean Patent No. 10-0177832 A composition using a licorice extract
Korean Patent Registration No. 10-0749233 Process for producing Angelicae Radix extract and composition thereof
Korean Patent No. 10-0726006 Pharmaceutical composition for suppressing cancer metastasis comprising polysaccharide derived from Angelica gigas Nakai as an active ingredient
Korean Patent Registration No. 10-0587179 Anti-hypertensive cystic root extract
Korean Patent Application No. 10-2008-0005192 [Technical Field]
Korean Patent No. 10-0286534 Antioxidant tea for aging delay (peony)
Korean Patent Application No. 10-2005-0067482 [
Korean Registered Patent No. 10-0261463 Process for the preparation of granulated daffodil tea using the raw material of Daejeon Daebok-tang
Korean Patent No. 10-0741488 Manufacturing Method of Tea Bags for Tea Bags
Korean Patent Application No. 10-2004-0067921 [Patent] Bio-red ginseng and ginseng saponification
Korean Patent Application No. 10-2003-0016557 A composition for leaching bio-red ginseng tea used in diabetic patients and a method for producing the same
Korean Patent No. 10-1071154 An anti-stress composition containing a sanjoin extract and a method for producing the same
Korean Patent No. 10-0763620 A composition for promoting the secretion of growth hormone containing an acid extract or betulinic acid as an active ingredient
Korean Patent No. 10-0883211 A method for producing health supplements using corn oil
Korean Registered Patent No. 10-0428251 A method for producing a traditional Chinese liquor using corn oil and a fermented soybean oil prepared by the method
Korean Patent No. 10-1120670 discloses a composition for improving blood flow including a fermented product of an acid drug, a method for producing the same, and a health functional food containing the same
Korean Patent No. 10-0990669 Patent Claims
Korean Patent No. 10-0524385 A composition for improving memory and enhancing adolescents learning ability containing extracts of pancreas, acidophilus,
Korean Patent No. 10-1041044 A composition for preventing and improving insomnia symptoms and a method for producing the same
Korea Patent No. 10-0449245 A composition for treating a neurological disease including MacMundo extract
Korea Patent No. 10-0635440 A composition for protecting brain cells and enhancing memory including MacMyodong extract
바람직한 구체예로서, 본 발명의 한방 약선차는 다음과 같이 제조될 수 있다.In a preferred embodiment, the herbal medicine of the present invention can be prepared as follows.
먼저, 백작약, 당귀, 숙지황, 천궁, 황기, 감초, 인삼, 백복신(백복령), 산조인(산대추), 대추, 산수유, 산약, 구기자, 오미자, 용안육, 내복자, 맥문동, 원지, 황금, 사인, 산사육(산사자)의 총 21종의 한약재를 각각 3.75g씩 취하고, 이에 약 5L의 물을 가해 100℃ 이상의 조건에서 열수 추출한다. 상기 열수 추출은 추출물의 브릭스가 7.5~8.5, pH가 5.5~6.0 및 고형분 함량이 5~15중량%인 상태에서 완료하여 열수 추출액을 얻을 수 있다. 얻어진 추출액은 통상의 방법으로 필터한 후, 감압분무건조 또는 동결건조하여 분말화한 다음, 한방 약재 추출물의 건조분말 100중량부에 대하여, 말토덱스트린 10~30중량부, 정백당 40~60중량부, 자일리톨 10~20중량부 및 구연산 0.1~2.0중량부를 첨가하여 혼합한 후, 분말 스틱제품으로 제조하였다. First of all, it is recommended to use the following ingredients: black peony, angelica, lily of the valley, celestial gland, lily of the valley, licorice, ginseng, white ginseng, 3. Salted salted herbs (21 kinds of medicinal herbs) are taken in 3.75g each, and about 5L of water is added, and hot water is extracted at 100 ℃ or higher. The hot water extraction can be completed with the bricks of the extract being 7.5 to 8.5, the pH of 5.5 to 6.0 and the solid content of 5 to 15% by weight to obtain a hot-water extract. The resulting extract is filtered and dried by reduced pressure spray drying or lyophilization to obtain a powder. 10 to 30 parts by weight of maltodextrin, 40 to 60 parts by weight of white sugar, 40 to 60 parts by weight of maltodextrin are added to 100 parts by weight of the dry powder of the herbal medicine extract, 10 to 20 parts by weight of xylitol and 0.1 to 2.0 parts by weight of citric acid were added and mixed to prepare a powder stick product.
본 발명의 한약재 조성물은 강력한 항산화, 항균 및 항혈전 활성으로 노화를 억제하며, 원기를 회복시켜 급성 심근 경색증, 가슴 통증, 호흡 곤란, 의식 소실, 허혈성 뇌졸중, 출혈성 뇌졸중, 두통, 운동 이상, 감각 이상, 성격 변화, 시력 저하, 간질 발작, 폐 혈전증, 심부정맥 혈전증, 하지 부종, 통증 및 급성 말초 동맥 폐쇄증 등을 예방하는 한방차 및 건강 기능 식품으로 유용하다.The herbal medicines composition of the present invention inhibits aging by a strong antioxidant, antibacterial and antithrombotic activity, and regenerates the epidermis, thereby preventing acute myocardial infarction, chest pain, dyspnea, loss of consciousness, ischemic stroke, hemorrhagic stroke, headache, , Personality change, vision loss, epileptic seizure, pulmonary thrombosis, deep vein thrombosis, lower limb edema, pain and acute peripheral arterial atresia.
본 발명의 한방차는 10g의 소포장으로 제품화될 수 있으며, 음용자의 나이, 성별, 체중에 따라 음용량이 달라질 수 있으나, 1회 1포, 1일 3~6회 음용하는 것이 바람직하다. The herbal tea of the present invention can be commercialized as a small packet of 10 g. It is preferable to drink one capsule at a time, three to six times a day, depending on the age, sex and body weight of the drinker.
이하, 본 발명의 구체적인 방법을 실시예를 통하여 보다 상세하게 설명한다. 하기 실시예는 본 발명의 바람직한 하나의 구체예일 뿐이며, 본 발명의 권리범위가 하기 실시예의 범위로 한정되는 것은 아니다.Hereinafter, the specific method of the present invention will be described in more detail by way of examples. The following examples are only a preferred embodiment of the present invention, and the scope of the present invention is not limited to the scope of the following examples.
[[ 실시예Example ]]
실시예Example 1: 21종 1: 21 species 한약제로부터From Chinese medicine 21대보탕의21 조제 및 성분 분석 Preparation and composition analysis
표 1에 나타낸 21종의 한약제는 국내산 한약재로, 각각 375g을 취한 후 물 500L를 가해 100~105℃의 조건에서 4시간 동안 열수 추출하였다. 이때 추출 완료를 평가하기 위해서는 브릭스(brix) 측정이 필요하며, 브릭스 7.5~8.5가 적당하다. 이때 추출액의 pH는 5.5~6.0, 고형분 함량은 10%의 상태가 되는 것이 바람직하다. The 21 kinds of herbal medicines shown in Table 1 were domestic herbal medicines. After taking 375 g each, 500 L of water was added and the mixture was subjected to hot water extraction at 100 to 105 ° C for 4 hours. At this time, a brix measurement is required to evaluate the completion of extraction, and Brix 7.5 to 8.5 is suitable. At this time, the pH of the extract is preferably 5.5 to 6.0, and the solid content is preferably 10%.
조제된 21대보탕의 총 플라보노이드 (total flavonoid), 총 폴리페놀 (total polyphenol), 총당 및 환원당 함량을 시판 쌍화탕과 비교하여 측정하였다. 총 플라보노이드 함량 측정은 각각의 시료를 18 시간 메탄올 교반 추출하고, 여과한 추출 검액 400 μl에 90 % diethylene glycol 4 ml를 첨가하고 다시 1 N NaOH 40 μl를 넣고 37 ℃에서 1 시간 반응 후 420 nm에서 흡광도를 측정하였다. 표준시약으로는 rutin을 사용하였다. 총 폴리페놀 함량은 추출 검액 400 μl에 50 μl의 Folin-ciocalteau, 100 μl의 Na2CO3 포화용액을 넣고 실온에서 1 시간 방치한 후 725 nm에서 흡광도를 측정하였다. 표준시약으로는 tannic acid를 사용하였다. 환원당은 DNS법으로, 총당은 phenol-sulfuric acid법을 이용하여 정량하였다. 그 결과는 다음 표 3에 나타내었다. The total flavonoid, total polyphenol, total sugar and reducing sugar contents of the prepared 21st Great Botany were measured in comparison with the commercial sodas. To determine the total flavonoid content, each sample was stirred for 18 hours in methanol, and 4 ml of 90% diethylene glycol was added to 400 μl of the filtered extract. 40 μl of 1 N NaOH was added thereto, followed by reaction at 37 ° C for 1 hour, Absorbance was measured. As a standard reagent, rutin was used. Total polyphenol content is obtained by adding 50 μl of Folin-ciocalteau, 100 μl of Na 2 CO 3 The saturated solution was added and allowed to stand at room temperature for 1 hour, and the absorbance was measured at 725 nm. Tannic acid was used as a standard reagent. Reducing sugar was determined by DNS method and total sugar was quantified by phenol-sulfuric acid method. The results are shown in Table 3 below.
그 결과 21대보탕은 시판 쌍화탕보다 pH가 약산성에 가까우며, brix 는 4.3 정도 낮은 것으로 나타나 시판 쌍화탕보다 덜 씨큼하고, 덜 단것으로 나타났다. 한편 유용 생리활성과 관련된 총폴리페놀 및 총플라보노이드 함량의 경우 21대보탕은 시판 쌍화탕보다 약 1.9배~2.8배 많은 것으로 나타났다. As a result, it was found that the pH of the 21st Daeboltang was slightly acidic and the brix was 4.3 lower than that of the commercial ssanghwangtang. On the other hand, total polyphenols and total flavonoid contents related to useful physiological activities were about 1.9 to 2.8 times higher than commercial ssanghwangtang.
실시예Example 2: 2: 21대보탕의21 항산화, 항세균 및 Antioxidants, antibiotics and 항혈전Anti-thrombosis 활성 평가 Activity evaluation
실시예 1 의 21대보탕의 항산화, 항세균, 항혈전 활성을 조사하였다. 먼저 항산화 활성은 DPPH (1,1-diphenyl-2-picryl hydrazyl) radical 소거능 및 ABTS [2,2-azobis(3-ethylbenzothiazoline-6-sulfonate)] radical 소거능 측정에 의해 평가하였다. DPPH 소거능의 경우 다양한 농도로 희석한 시료 20 ㎕에 99.5% 에탄올에 용해시킨 2 x 10-4M DPPH 용액 380 ㎕를 넣고 혼합하여 37℃에서 30분 동안 반응시킨 후, 516 nm에서 microplate reader (Asys Hitech, Expert96, Asys Co., Austria)를 사용하여 흡광도를 측정하였다. DPPH free radical 소거능은 시료첨가구와 비첨가구의 백분율로 표시하였다.The antioxidant, antibacterial activity and antithrombotic activity of the 21st Great Botany of Example 1 were examined. First, antioxidant activity was evaluated by measuring DPPH (1,1-diphenyl-2-picryl hydrazyl) radical scavenging activity and ABTS [2,2-azobis (3-ethylbenzothiazoline-6-sulfonate)] radical scavenging ability. For DPPH scavenging ability, 380 μl of 2 × 10 -4 M DPPH solution dissolved in 99.5% ethanol was added to 20 μl of diluted samples at various concentrations, and the mixture was reacted at 37 ° C. for 30 minutes. Hitech, Expert 96, Asys Co., Austria). The DPPH free radical scavenging activity was expressed as a percentage of sample addition and non-addition.
ABTS 소거능의 경우 7 mM ABTS (Sigma Co., USA) 5 ml와 140 mM potassium persulfate 88 ml를 섞은 후 상온에서 16시간 빛을 차단하여 ABTS 양이온을 형성시켰으며, 이후 이 용액을 414 nm에서 흡광도 값이 1.5가 되도록 에탄올로 희석하였다. 조제된 희석용액 190 ml와 다양한 농도로 조제된 시료 10 ml를 혼합한 후 상온에서 6분간 반응시킨 후 734 nm에서 흡광도를 측정하고 다음의 식에 의해 ABTS radical 소거능를 계산하였다. For ABTS scavenging activity, 5 ml of 7 mM ABTS (Sigma Co., USA) and 88 ml of 140 mM potassium persulfate were mixed and then blocked for 16 hours at room temperature to form ABTS cations. The solution was then dialyzed against absorbance at 414 nm Was diluted with ethanol to 1.5. After mixing 190 ml of the prepared diluted solution and 10 ml of the samples prepared at various concentrations, the reaction was allowed to proceed at room temperature for 6 minutes. Absorbance was measured at 734 nm and the ABTS radical scavenging activity was calculated by the following equation.
ABTS radical 소거능 (%) = [(C-S)/C] x 100, ABTS radical scavenging ability (%) = [(C-S) / C] x 100,
C: 용매 대조구 DMSO 첨가시의 흡광도, S, 시료 첨가시의 흡광도. C: absorbance at the time of addition of the solvent control DMSO, S, absorbance at the time of addition of the sample.
각각의 항산화능은 50% 라디칼 소거능에 필요한 한방차의 농도로 나타내었으며, 표 4와 같다. 그 결과 본 발명의 21대보탕은 시판 쌍화탕보다 약 2배 이상의 강력한 항산화능을 나타냄을 확인하였다. Each antioxidant activity was expressed by the concentration of herbal tea required for 50% radical scavenging ability, as shown in Table 4. As a result, it was confirmed that the 21st Great Botany of the present invention exhibited a strong antioxidative ability about twice as much as that of the commercial Ssanghwa.
한편 항세균 활성은 microbroth dilution법을 이용하여 최소생육억제농도 (minimal inhibitory concentration: MIC)를 측정하여 평가하였다. 사용균주로는 그람 음성균으로 Salmonella typhimurium KCTC 1926, Escherichia coli KCTC 1682, Proteus vulgaris KCTC 2433, Pseudomonas aeruginosa KACC 10186, 그람 양성균으로는 Listeria monocytogenes KACC 10550, Staphylococcus aureus KCTC 1916, Staphylococcus epidermidis ATCC 12228, Bacillus subtilis KCTC 1924를 사용하였다. 배양배지로는 nutrient broth(Difco Co. USA)를 이용하여 각각 37℃에서 preincubation한 후, 각각의 한방차가 5.0%, 2.5% 1.2% 및 0.6% 되도록 첨가된 배지 9 ml에 O.D.(600 nm) 0.1이 되도록 조정된 각각의 균액 1 ml을 첨가하고 48시간 배양하였다. 이후 육안 판정 및 현미경 검경을 통해 생육이 나타나지 않는 생즙 농도를 MIC로 나타내었다. 그 결과 시판 쌍화탕에서는 5% 이상에서 항세균 활성이 인정되는 반면 21대보탕에서는 2.5%~1.2%에서 우수한 항세균 활성이 나타났다(결과 미제시). 이러한 결과는 21대보탕에서 많이 함유하고 있는 폴리페놀 및 플라보노이드 성분에 의한 항산화 및 항균 활성으로 이해된다. On the other hand, the antibacterial activity was evaluated by measuring the minimal inhibitory concentration (MIC) using microbroth dilution method. The strains used were Gram-negative bacteria such as Salmonella typhimurium KCTC 1926, Escherichia E. coli KCTC 1682, Proteus vulgaris KCTC 2433, Pseudomonas aeruginosa KACC 10186, Gram positive bacteria such as Listeria monocytogenes KACC 10550, Staphylococcus aureus KCTC 1916, Staphylococcus epidermidis ATCC 12228, Bacillus subtilis KCTC 1924 were used. The culture medium was preincubated at 37 ° C with nutrient broth (Difco Co., USA), and OD (600 nm) 0.1 was added to 9 ml of the medium supplemented with 5.0%, 2.5%, 1.2% and 0.6% And then cultured for 48 hours. After that, the concentration of fresh juice in which no growth was observed by visual inspection and microscopic examination was indicated by MIC. As a result, antimicrobial activity was recognized at more than 5% in the commercial ssanghwang, while the antimicrobial activity was excellent at 2.5% ~ 1.2% in 21. These results are understood as the antioxidant and antimicrobial activities of polyphenols and flavonoids which are contained in the 21st Daeboltang.
한편 항혈전 활성은 트롬빈 타임을 측정하여 평가하였으며, 분석방법은 다음과 같다. 37 ℃에서 0.5 U 트롬빈 (Sigma Co., USA) 50 μl와 20 mM CaCl2 50 μl, 다양한 농도의 시료 추출액 10 μl를 Amelung coagulometer KC-1A (Japan)의 튜브에 혼합하여 2 분간 반응시킨 후, 혈장 100 μl를 첨가한 후 혈장이 응고될 때까지의 시간을 측정하였다. 대조로는 아스피린 (Sigma Co., USA)을 사용하였으며, 용매 대조구로는 시료 대신 물을 사용하였다. 물의 경우 18.5 초의 응고시간을 나타내었다(Sohn et al., 2004. Kor . J. Pharmacogn 35. 52-61; Kwon et al., 2004. J. Life Science, 14. 509-513; 류 등 2010. J. Life Science, 20. 922-928). On the other hand, antithrombotic activity was evaluated by measuring thrombin time, and the analytical method was as follows. 50 μl of 0.5 U thrombin (Sigma Co., USA) and 20 mM CaCl 2 50 μl, 10 μl of various concentrations of sample extract were mixed in a tube of Amelung coagulometer KC-1A (Japan) and allowed to react for 2 minutes. Then, 100 μl of plasma was added and the time until the plasma coagulated was measured. As a control, aspirin (Sigma Co., USA) was used, and water was used as a solvent control instead of the sample. And water showed a coagulation time of 18.5 seconds (Sohn et al ., 2004. Kor . J. Pharmacogn 35, 52-61; Kwon et al ., 2004. J. Life Science , 14: 509-513; Ryu et al. 2010. J. Life Science , 20: 922-928).
트롬빈 저해 효과는 3 회 이상 반복한 실험의 평균치로 나타내었으며, 측정결과 21대보탕과 시판 쌍화탕은 아스피린에 비해서는 미약한 항혈전 활성을 나타내었으나 (표 5), 어느 정도의 항혈전 활성이 인정되어 한방차와 같이 장기간 음용시에는 항혈전 활성을 기대할 수 있으리라 예상된다. The thrombin inhibitory effect was expressed as the average value of the experiment repeated three or more times. As a result, the 21st Daeho-tang and the Ssanghwa-tang showed a slight antithrombotic activity as compared with aspirin (Table 5) It is anticipated that anti - thrombotic activity can be expected in long - term drinking such as oriental tea.
이러한 결과는 21대보탕이 마음을 진정시키고, 편안히 하는 효과 이외에도 우수한 항산화능, 항균력을 나타내어 노화억제 및 질병예방에 기여할 수 있음을 제시하고 있다. These results suggest that 21st Daebo-tang can calm the mind and contribute to anti-aging and disease prevention by showing excellent antioxidant ability and antibacterial power in addition to relaxing effect.
실시예Example 3: 3: 21대보탕의21 건조분말 제조와 이를 포함하는 Dry powder preparation and its 관능성과Sensuality 기호도가 높은 분말스틱 제품 개발 Developed powder stick products with high preference
상기 실시예 1에서 얻은 21대보탕을, 50~70 메쉬의 체를 사용한 통상의 방법으로 필터한 후, 동결건조, 감압 분말건조, 고온건조, 감압건조하여 분말을 제조하였으며, 그 결과 동결건조 및 감압 분말건조로 제조된 분말만이 열수 및 냉수에 잘 녹는 특성을 나타내었다. 고온온건조 및 감압건조시에는 끈적끈적한 카라멜 형태로 얻어져, 분말제품으로 개발하기 위해서는 동결 및 분무건조가 필수적이었다. 동결건조시 수율은 10.2±0.12% 이었으며, 분무건조시는 동결건조보다 다소 낮은 9.5±0.15%의 수율을 나타내었다. 이후 각각의 건조방식으로 제조된 분말을 다시 5% 농도로 수화시킨 후의 특성을 평가하였다 (표 6). The 21st treasure trove obtained in Example 1 was filtered by a conventional method using a sieve of 50 to 70 mesh and then subjected to freeze-drying, reduced-pressure drying, high-temperature drying and vacuum drying to obtain powders. As a result, Only the powders prepared by powder drying showed good melting properties in hot and cold water. When dried at high temperature and dried under reduced pressure, it was obtained as a sticky caramel, and freeze-drying and spray drying were indispensable for development as a powder product. Yield was 10.2 ± 0.12% at lyophilization and 9.5 ± 0.15% at spray drying was somewhat lower than lyophilization. Thereafter, the powders prepared by the respective drying methods were again hydrated at a concentration of 5%, and the properties thereof were evaluated (Table 6).
이때 색차 분석은 Hunter Color Difference meter (Super color SP-80 Colormeter, Tokyo Denshoku Co., Japan)를 이용하여 측정하였으며, 명도 (백색 100 ~ 0 검정색), 적색도 (적색 100 ~ -80 녹색), 황색도 (황색 70 ~ -80 검정색)를 측정하였다. 이때 표준백판의 색도는 L값이 92.44, a값이 -0.06, b값이 1.35로 기준을 정하였으며, 시료당 3회 측정하여 평균값을 구하여 나타내었고 색차(△E)는 다음의 식을 이용하여 계산하였다.The color difference was measured using a Hunter Color Difference meter (Super Color SP-80 Colormeter, Tokyo Denshoku Co., Japan), and the lightness (white 100 to black), redness (red 100 to -80 green) (Yellow 70 ~ -80 black) were measured. The chromaticity of the standard white plate was determined as L = 92.44, a value of -0.06 and b = 1.35, and the average value was measured three times per sample. The color difference ( ΔE ) Respectively.
한편 관능성 평가는 안동대학교 식품영양학과 연구원 20명을 대상으로 5점 척도로 평가하였으며, 아주 나쁘다 1점, 조금 나쁘다 2점, 보통이다 3점, 조금 좋다 4점, 매우 좋다 5점으로 표기하였다. On the other hand, the sensory evaluation was evaluated on a scale of 5 points for 20 researchers of the Institute of Food and Nutrition, Andong National University, and it was rated as very bad 1 point, slightly worse 2 point, average 3 point, little good 4 point, .
그 결과, 동결건조와 감압분무건조시 색차와 pH, 총폴리페놀 및 총플라보노이드 함량에는 변화가 거의 없으나, 감압 분무건조시 총당 및 환원당 함량에서 증가가 나타나며 또한 풍미와 목넘김, 전체적 선호도가 증가됨을 알수 있다. 따라서 감압분무 건조중 동결건조와는 달리 고형분의 분해 및 다당류의 분해가 나타나는 것으로 추측되며, 향후 분말스틱제품 개발시 분무건조 또는 동결건조가 바람직함을 알 수 있다. As a result, there was little change in color difference, pH, total polyphenol and total flavonoid content during freeze drying and vacuum spray drying, but the increase in total sugar and reducing sugar content in vacuum spray drying showed an increase in flavor, have. Therefore, unlike lyophilization during decompression spray drying, it is presumed that the solids are decomposed and polysaccharide is decomposed, and spray drying or freeze drying is preferable in the development of powder stick products in the future.
한편 각각의 건조분말을 증류수에 녹여 인간 적혈구에 대한 급성 용혈독성을 평가한 결과 5 mg/ml 농도까지 용혈 활성은 나타나지 않았다. On the other hand, when each dry powder was dissolved in distilled water, the acute hemolytic toxicity to human erythrocytes was evaluated. No hemolytic activity was observed up to the concentration of 5 mg / ml.
실시예Example 4: 4: 21대보탕21 Great Adventures 분말을 포함하는 Powders 관능성Sensuality 강화, 기호성 증가 분말 스틱제품 제조 Manufacture of powder stick products for strengthening and increasing palatability
관능성과 기호성을 증가시키기 위해 21대보탕의 건조분말과 다양한 부재료를 첨가하며, 최대의 기호성을 나타내는 제품 레시피를 완성하였다. 최종 확정 레시피로 제조된 한방차는 21대보탕의 건조분말 100g, 말토덱스트린 20g, 정백당 50g, 자일리톨 15g 및 구연산 1g을 포함한다. 제조된 조성물은 10g 씩 방습포장하였으며, 이후 90ml 열수에 녹인 후 시판 쌍화탕 제품과 관능성 평가를 수행하였다. 그 결과 최종 조성물은 시판 제품보다 우수한 관능성을 나타내었으며, 한약에 대해 거부감을 나타내는 청소년 및 20대 여성들도 부담감 없이 마실 수 있음을 확인하였다(표 7).In order to increase sensuality and palatability, we added 21st Daebotang dry powder and various ingredients to complete the product recipe which shows the maximum preference. The herbal tea prepared as the final confirmed recipe contains 100 g of dry powder of 21 Great Botany, 20 g of maltodextrin, 50 g of whitening white sugar, 15 g of xylitol and 1 g of citric acid. The prepared composition was moisture - proof packaged in 10 g portions, and then dissolved in 90 ml of hot water, and then subjected to a sensory evaluation with a commercial hot water bottle. As a result, the final composition showed better sensory properties than the commercial products, and it was confirmed that the adolescents and women in their twenties who can resist the Chinese medicine can drink without any burdens (Table 7).
Claims (5)
열수 추출을 완료한 후 동결건조 또는 감압분무건조 과정을 더 포함하여 제조되는 것을 특징으로 하는 한약재 조성물.The method according to claim 1,
And further comprising a step of lyophilization or vacuum spray drying after completion of the hot water extraction.
상기 한방 약선차는 상기 한약재 조성물 100중량부에 대하여, 말토덱스트린 10~30중량부, 정백당 40~60중량부, 자일리톨 10~20중량부 및 구연산 0.1~2.0중량부를 포함하는 것을 특징으로 하는 한방 약선차.The method of claim 3,
Wherein the herbal medicine composition comprises 10 to 30 parts by weight of maltodextrin, 40 to 60 parts by weight of corn flakes, 10 to 20 parts by weight of xylitol and 0.1 to 2.0 parts by weight of citric acid based on 100 parts by weight of the herbal composition. .
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