KR102356517B1 - Health supplement composition using herbal medicine and health supplement food using the same - Google Patents

Abstract

The present invention relates to a health supplement composition using a herbal material and a health supplement food using the same.
The health supplement composition using the herbal material according to the present invention is a herbal material such as hyssop, ginseng, baekchul, dang ginseng, maple, mulberry bark, hwangbaek, sukjihwang, hyeonsam, taeksa, hwanggi, casualty, seonmo, faemo, gugija, sangbaekpi, hwangjeong, omija and semi-links.
With the above configuration, the health supplement using the herbal material according to the present invention can easily ingest the useful ingredients of the natural herbal material and provide nutrients to the ingester so that they can lead a healthy life.

Description

Health supplement composition using herbal material and health supplement using the same

The present invention relates to a health supplement composition using a herbal material and a health supplement using the same, and more particularly, to a health supplement composition including a natural herbal ingredient as an active ingredient, thereby making it easier to ingest useful ingredients of a natural herbal material. It relates to a health supplement composition using herbal materials that can provide nutrients so that people can live a healthy life and lead a healthy life, and a health supplement food using the same.

The importance of nutrition has been re-recognized as the standard of living has greatly improved due to the improvement of national income following economic growth, and interest in health has increased. As the awareness that daily food alone is insufficient to maintain the balance and nutrition of the human body is spreading, the consumption of health food is gradually increasing.

The reason why health functional foods are in the spotlight is that the intake of micronutrients is decreasing due to the advancement of an aging society, an increase in chronic diseases such as high blood pressure, diabetes, and cardiovascular diseases caused by eating habits, and the development of instant foods. As the effects of health promotion and disease prevention by the active ingredients of food have been proven, the functionality of food, that is, the bioregulatory function of food, is attracting attention, and many products using it are being made.

Health functional food refers to a food manufactured using raw materials or ingredients with useful functionality. Here, functional food refers to obtaining useful effects for health purposes such as regulating nutrients or physiological effects on the structure and function of the human body. .

On the other hand, as a conventional method of taking herbal medicines (oriental medicines), there is a method of taking herbal medicines by decoction with a conventional medicinal water heater. This method has a disadvantage in that the response ability is significantly lower than that of Western medicine in emergency patients who urgently need to take the medicine because it is decoctioned for a long time and eaten after cooling properly.

Due to the inconvenience of taking, there are herbal teas such as Galgeuntang or Ssanghwa tea prepared in advance in liquid form on the market. There is also the inconvenience of having to reheat these herbal teas in boiling water.

Herbal medicines that can be taken in various forms have been developed due to the problems of the above dosage methods. For example, Korean Patent Publication No. 10-2005-0053572 discloses, after drying ginseng, jujube, chestnut and garlic, Disclosed is a 'healthy herbal medicine tea bag', which is pulverized and mixed in a certain ratio, sealed in a tea bag, and used, and in the Republic of Korea Utility Model Publication No. 20-399746, 'Oriental herbal medicine tea bag' is used by sealing the dried powder tea bag' is disclosed.

However, the herbal medicine used as the content of the tea bag can be used in a tea bag through simple processing such as drying and pulverization, and medicinal materials such as Astragalus, Angelica, Peony, Hwangjeong, Cheongung, Baekchul, and Suo are simply dried and crushed as described above. There was a problem in that it was difficult to completely elute the active ingredients of each drug when it was treated and used in a tea bag.

Domestic Registered Patent No. 10-1966021 (Registered on March 29, 2019) Domestic Registered Patent No. 10-1812725 (Registered on December 20, 2017) Domestic Patent Publication No. 10-2016-0074300 (published on June 28, 2016)

The present invention is a health supplement using herbal medicines that can easily ingest useful ingredients of natural herbs and provide nutrients to lead a healthy life by composing a health supplement composition including natural herbal ingredients as active ingredients To provide a composition and a health supplement using the same.

In addition, the present invention is to provide a health supplement composition and a health supplement using the herbal material effective for men's health because the secretion of testosterone, a male hormone, is enhanced by including natural herbal ingredients beneficial to men's health.

Various problems to be solved by the present invention are not limited to the above-mentioned problems, and other problems not mentioned will be clearly understood by those skilled in the art from the following description.

The health supplement composition using the herbal material according to the present invention is a herbal material such as hyssop, ginseng, baekchul, dang ginseng, maple, mulberry bark, hwangbaek, sukjihwang, hyeonsam, taeksa, hwanggi, casualty, seonmo, faemo, gugija, sangbaekpi, hwangjeong, omija and semi-links.

3 to 7 parts by weight of the hyssop, 3 to 7 parts by weight of hummus, 3 to 7 parts by weight of baekchul, 3 to 7 parts by weight of ginseng, 3 to 7 parts by weight of maple, 3 to 7 parts by weight of mulberry skin, 3 to 7 parts by weight of yellow white ginseng , 3 to 7 parts by weight of red ginseng, 3 to 7 parts by weight of ginseng, 3 to 7 parts by weight of ginseng, 3 to 7 parts by weight of Astragalus, 3 to 7 parts by weight of casualties, 3 to 7 parts by weight of sun hair, 3 to 7 parts by weight of ginseng, It may be included in a weight ratio of 3 to 7 parts by weight of Goji berry, 3 to 7 parts by weight of sangbaekpi, 3 to 7 parts by weight of Hwangjeong, 3 to 7 parts by weight of Omija, and 3 to 7 parts by weight of Banyan.

In addition, the health supplements using the herbal material according to the present invention are hyssop, ginseng, baekchul, danang ginseng, maple, mulberry, hwangbaek, sukjihwang, hyeonsam, taeksa, hwanggi, casualty, seonmo, baekchul, gugija, sangbaekpi, hwangjeong, omija and Herbal medicine powder is prepared by grinding a composition consisting of semi-lily, and the herbal medicine powder is fermented with Hong Guk-gyun.

3 to 7 parts by weight of the hyssop, 3 to 7 parts by weight of hummus, 3 to 7 parts by weight of baekchul, 3 to 7 parts by weight of ginseng, 3 to 7 parts by weight of maple, 3 to 7 parts by weight of mulberry skin, 3 to 7 parts by weight of yellow white ginseng , 3 to 7 parts by weight of red ginseng, 3 to 7 parts by weight of ginseng, 3 to 7 parts by weight of ginseng, 3 to 7 parts by weight of Astragalus, 3 to 7 parts by weight of casualties, 3 to 7 parts by weight of sun hair, 3 to 7 parts by weight of ginseng, It may be included in a weight ratio of 3 to 7 parts by weight of Goji berry, 3 to 7 parts by weight of sangbaekpi, 3 to 7 parts by weight of Hwangjeong, 3 to 7 parts by weight of Omija, and 3 to 7 parts by weight of Banyan.

The fermentation may be carried out by mixing the herbal medicine powder and Hong Guk-gyun and then fermenting for 20 to 50 hours at a temperature of 60 to 70 ℃.

After fermenting the herbal medicine powder with Hong Guk-gyun, it may be prepared in the form of powder, granules, tablets, capsules, beverages or extracts.

Specific details of other embodiments are included in the detailed description.

The health supplement using the herbal material according to the present invention can easily ingest the useful ingredients of the natural herbal material and provide nutrients to the ingester so that they can lead a healthy life.

In addition, the health supplement using the herbal material according to the present invention contains natural herbal ingredients beneficial to men's health, so that the secretion of testosterone, a male hormone, is enhanced, so that it is effective for men's health.

It will be fully understood that embodiments of the technical idea of the present invention may provide various effects not specifically mentioned.

1 is a graph showing the cytotoxicity results through the MTT assay for the liquid extract of Example 1.
Figure 2 is a graph showing the testosterone (testosterone) hormone activity evaluation results of the liquid extract of Example 1.

Advantages and features of the present invention, and methods for achieving them, will become apparent with reference to the embodiments described below in detail. However, the present invention is not limited to the embodiments described herein and may be embodied in other forms. Rather, the embodiments introduced herein are provided so that the disclosed subject matter may be thorough and complete, and that the spirit of the present invention may be sufficiently conveyed to those skilled in the art.

The terms used in the present application are only used to describe specific embodiments, and are not intended to limit the present invention. The singular expression includes the plural expression unless the context clearly dictates otherwise.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as those defined in commonly used dictionaries should be interpreted as having meanings consistent with the meanings in the context of the related art, and should not be interpreted in an ideal or excessively formal meaning unless explicitly defined in the present application. does not

Hereinafter, the health supplement composition using the herbal material according to the present invention will be described in detail with reference to preferred examples.

The health supplement composition using the herbal material according to the present invention is hyssop, ginseng, baekchul, dang ginseng, maple, mokdanpi, hwangbaek, sukjihwang, hyeonsam, taeksa, hwanggi, casualty, seonmo, faemo, gugija, sangbaekpi, hwangjeong, omija and ring includes lily

In addition, the health supplement composition using the herbal material according to the present invention contains 3 to 7 parts by weight of hyssop, 3 to 7 parts by weight of mulberry, 3 to 7 parts by weight of baekchul, 3 to 7 parts by weight of sugar ginseng, 3 to 7 parts by weight of maple, 3 to 7 parts by weight of mulberry skin, 3 to 7 parts by weight of yellow sage, 3 to 7 parts by weight of red ginseng, 3 to 7 parts by weight of ginseng, 3 to 7 parts by weight of ginseng, 3 to 7 parts by weight of astragalus, 3 to 7 parts by weight of casualties, seonmo 3 to 7 parts by weight, 3 to 7 parts by weight of sagebrush, 3 to 7 parts by weight of Goji berry, 3 to 7 parts by weight of sagebrush, 3 to 7 parts by weight of hwangseok, 3 to 7 parts by weight of Schisandra, and 3 to 7 parts by weight of banyan tree. can be included as

The hyssop is a perennial plant that grows in the mountains and fields south of central Korea, and its important ingredients are saponin, potassium, and mucilage, and it is used as a medicine to treat liver and kidney diseases. It works to strengthen the skin, and triperipin and saponin enhance immunity, so it is used as a medicine. In the present invention, the mussels may be immersed in alcohol for 20 to 30 hours, then dried and roasted.

The Anemarrhena asphodeloides is a plant belonging to the family Liliaceae, and is a perennial plant that is native to China and cultivated in the central region of Korea. Usually dried root rhizomes have been used as medicine, and are known to have anti-inflammatory, antipyretic, antidiarrheal, diuretic, and sedative effects. It is known to contain steroid sapogenin, flavonoids, and tannins, such as salsasaponin and malcogenin (Markogenin; 2-hydroxy sarsasapogenin), in addition to 6% of Asphonin as an active ingredient of Zemo. . In the present invention, the zemo may be used after being immersed in alcohol for 20 to 30 hours and then dried and roasted.

The baekchul (白朮) is the rhizome of Atractylodes japonica Koidzumi or Atractylodes macrocephala Koidzumi, Compositae of the Asteraceae family. It is good for dilute stool or diarrhea, and helps excretion of water when the body is swollen and indigestion due to stagnant water. It is also used for chest jumps, coughs, and clear sputum caused by accumulation of water and moisture in the rain. It is also used for vomiting during pregnancy and when the skin sweats spontaneously due to weakness in the nasal passages. do. It is also used for colds and pain in the extremities with gastrointestinal disorders. It is also known to have an excellent effect on improving appetite.

Pharmacologically, it has been reported that weight gain and endurance increase, gluttony ability, and cellular immune function promotion in mice were reported. In addition, intestinal inhibitory and excitatory action, anti-ulcer and liver function protective action, immune function enhancement action, vasodilator action, diuretic action and blood sugar lowering action, anticancer action, etc. have been reported. In the present invention, the baekchul may be immersed in rice water for 20 to 30 hours, then dried and roasted.

Dang ginseng is the root of Mansam (黨蔘), a perennial herb belonging to the family Campanulaceae. It has a sweet taste, smooth nature, and has the effect of replenishing energy and rejuvenating blood by acting on menopause. And gihyeol weakness (气血虛弱) after illness is a drug commonly used for symptoms. Dang ginseng has a similar action to that of ginseng, so it is commonly used as a substitute for ginseng for the control of bogie and dry rain.

The chemical components of sugar ginseng include saponin and trace amounts of alkaloids, proteins, starch, vitamins A ₁ , A ₂ and the like. Ginseng (黨蔘) has long been said to be effective for tonicity, health, weakness, anemia, and leukemia in the folklore. Regarding its pharmacological action, it is effective in increasing red blood cells, decreasing white blood cells, and decreasing lymphocytes. There is, and its water immersion solution is effective for early diabetes by increasing blood sugar.

The maple (Dioscorea quinquelobata Thunb) is a perennial tendril, and has a thick and hard rhizome, and its tough stem extends long and climbs to other objects. The leaves are located opposite each other, and the overall heart-shaped leaf body is divided into 5 to 9 branches to the middle, and the tip of the divided piece is sharp and the edge is flat.

The length of the leaves of the maple is 6-12 cm, and male and female flowers bloom on different leaves. All flowers hang down in the shape of an ear on a long flower stalk that grows from the leaf axil. The male flower heads are divided into several branches, but the female flower heads do not. The stem-shaped flower is split into six branches. The diameter of the flower is about 4mm and the color is green.

The maple leaves are bitter in nature and slightly cold in nature, and they return to liver and menopause. In oriental medicine, maple is known to get rid of customs, improve blood circulation, pass through meridians, clear walls, and stop coughing. In the present invention, the maple leaves may be immersed in rice water for 20 to 30 hours, then dried and roasted.

Mokdanpi is a root bark of Paeonia suffruticosa Andrews belonging to the family Paeoniaceae, and has been widely used in Oriental medicine because it has cheongyeolyanghyeol, hwalyeolsanfish, and detoxifying ischemia. It has been reported that Mokdanpi extract inhibits the release of IL-8 and MCP-1, which are types of chemokines, in vitro, and also inhibits the expression of iNOS and COX-2, which are inflammatory mediators. In the present invention, the wood danpi may be roasted and used black.

The Hwangbaek (黃栢, Phellodendri Cortex) is a dried bark of a Hwangbaek tree (Phellodendron amurense Rupr) belonging to the Rutaceae family. Blood pressure lowering action, central nervous system inhibitory action (KulkarniSK & Dhir A, Phytother Res 24, pp317-324, 2009), acetylcholine enhancing action and anti-inflammatory action (Uchiyama T et al, Yakugaku Zasshi 109, pp672-676, 1989) , is known to have antioxidant and anti-aging effects (Kong LD et al, Zhongguo Zhong Yao Za Zhi 26, pp245-248, 2001), and to enhance skin immunity. In the present invention, the hwangbaek may be immersed in alcohol for 20 to 30 hours, then dried and roasted.

The raw root of Rehmannia glutinosa Liboschtz var purpurea Makino is washed with water and steamed several times with alcohol to give it a black luster, and then dried. Rehmannia is a plant of the ginseng family, and it is a perennial herb with a height of 15 to 25 cm. Long oval or long egg-shaped. Mottled pink flowers bloom on the upper part of the stem in early summer. The root contains the iridoid glycosides catalpol, mannitol, and lehmanin. When the roots are dried or steamed and dried, the black color is due to catalpol.

Rehmannia glutinosa (Rehmannia glutinosa Libosch var purpurea Makino) is a perennial herb belonging to the family Scrophulariaceae. Saengjihwang is widely recognized for its efficacy in bohyeol, tonicity, sedation, anemia, hematemesis, hemorrhage, uterine bleeding, and tuberculosis weakness. In general, dried dried saengjihwang is generally classified as Rehmanniae Radix Preparata, which is obtained by adding dried saengjihwang to alcoholic beverages such as hwangju or white wine, steaming and drying it. are using

Sukjihwang has the effect of replenishing blood and consonants, and is used for menstrual irregularities, weak constitution, stunted growth in children, dementia, premature ejaculation, and erectile dysfunction. In addition, recent effects of improving blood circulation to improve peripheral microcirculation in various chronic diseases, increase in blood superoxide dismutase and glutathione peroxidase and inhibition of lipid peroxidation, immune increase effect, anticancer action , an increase in the activity of the fibrinolytic system, a decrease in polybrene-induced erythrocyte aggregation, and an increase in erythrocyte deformability and ATP content have been reported.

The ginseng (Scrophularia Buergeriana) is a perennial herbaceous plant belonging to the family Hyeonsamdae, and is also referred to as middle daisy, modern (玄臺), gwijang (鬼藏), and chukhor (逐 horse). Hyeonsam grows in mountainous areas and is used as an antipyretic agent for sore throat, boils, and lymphadenitis.

The ginseng (玄蔘) is known in oriental medicine as an inhibitory action against P. aeruginosa, dilates blood vessels, lowers blood pressure, and lowers blood sugar. It is a herbal medicine that causes heart poisoning when used in small amounts and has a mild gangsim action. In the present invention, the present ginseng may be immersed in alcohol for 20 to 30 hours, then dried and roasted.

The taxa (澤瀉) is a perennial sotaek (pond) plant belonging to the family Alismataceae, and in Korea, two types are distributed: A canaliculatum and A orientale (Sam) Juz. Among them, plantain yitaxa is mainly used as a herbal medicine, and the fine root and bark of the tuber of the plantain yataxa are removed and used as an herbal medicine Alismatis Rhizoma. Taxa has the effect of improving uremia and is used in the treatment of hypertension, allergy, cholesterolemia, fatty liver, and hyperlipidemia. In the present invention, the taxa may be used after mixing 6.25 g of saline per 500 g and roasting.

The astragalus (Astragalus membranaceus) is a dicotyledonous plant, a perennial herb of the Rosaceae leguminous family, and grows in a rock crevice in a mountainous area. It is mainly distributed in Korea, Japan, Manchuria, northeastern China, and eastern Siberia. Astragalus is commonly cultivated as a medicinal herb. In oriental medicine, Astragalus is harvested in autumn, removed from the outcrops and fine roots, and dried in sunlight. It is prescribed for prolapse, uterine prolapse, visceral drainage, cold sweat, and peripheral nerves.

Astragalus having the above medicinal effects is used as a part of herbal medicine, but in the most commonly used form, it is used to boil astragalus with chicken when ingesting samgyetang on a summer bok day. Astragalus is mainly used in oriental medicine rather than food. It is used for diuretic, diuretic, tonic and blood pressure lowering purposes. In pharmacological experiments, diuretic, tonic, blood pressure lowering, blood sugar lowering, immune enhancing, antitumor, and Various physiological functions such as antiviral action have been confirmed, and physiologically active substances present in Astragalus include formononetin, one of isoflavone glycosides, triterpenoide glycoside, β-sitosterol, stimast-4-en-6β-ol-3-one, etc. As the family saponins, astragaloside and sugar are known as main components. In the present invention, the astragalus may be roasted and used.

The casualty (Cnidi Fructus) means the dried fruit of a plant belonging to the Umbrella family, such as Torilis japonica Decandolle or Cnidium monnieri (L) Cussion, and includes all natural, hybrid, or mutant casualties. The casualty is a biennial plant of the buttercup family. The young shoots are eaten as vegetables, and the fruits are used as astringents, anti-inflammatory agents, and insecticides. In addition, since the casualty has a therapeutic effect on skin diseases, it has been used as an external drug for skin eczema, allergic dermatitis, and ooze. In the present invention, the casualties may be roasted and used.

The glandular hair (仙茅) is a rhizome of Curculigo orchioides Gaertner belonging to the family Amarylidaceae, and has effects such as whole kidney Yang and gangungol (强筋骨). It contains seeds, lycorin, aliphatic hydroxyketones, mucorage, etc. It is known that the methanol extract of glandular hair improves the phagocytic ability of macrophages and is effective in glucoside fractionation. In the present invention, the seon hair may be cut with a bamboo knife or copper knife, immersed in rice water, discarded when red water comes out, and immersed in alcohol for 20 to 30 hours, then dried and roasted.

It belongs to the family Liliaceae, and its Latin name is Fritillariae Bulbus. The shell includes a planer from which the core is removed and the main plate from which the core is not removed. The planer is a scaly stem, and the single scaly leaf of the outer layer of the scaly stem is almost crescent-shaped, and has a height of 1 to 2 cm, a width of 20 to 35 mm, the outer surface is milky white to light yellow, and the inner surface is white or light brown and contains white powder. Covered.

The bulbs of Fritillaria thunbergii have anticancer effects and hypotensive effects such as tumors and breast cancer, and are effective in cough, sputum, pneumonia, tonsillitis, sore throat, bronchitis, dry mouth, cuts, boils, It is known to be effective against insect bites.

The Goji (Lycium chinense) is a fruit of the Goji tree belonging to the family Solanaceae. Goji berry is a round or oval berry, and when dried, the outside is wrinkled and the inside contains many seeds. Goji berry contains betaine, zeazantin, carotene, thiamine, vitamins A, B ₁ , B ₂ , C, pizalien and β-sistosterol. It contains a large amount of and various inorganic components, so it has the effects of tonicity and coercion, and it is effective in protecting the liver by suppressing and lowering the absorption of low specific cholesterol in the intestine. It is known to have excellent preventive and therapeutic effects on adult diseases such as angina pectoris, arteriosclerosis, and diabetes, and at the same time, it is also known to be excellent in protecting eyesight. In the present invention, the goji berry can be used after being immersed in makgeolli for 20 to 30 hours and then steamed in 9 packs and 9 bags.

The Sangbaekpi is known to have various effects from ancient times as the root skin of a plant of the genus Morus, which is a deciduous tree belonging to the Morus family. It was also reported that the epithelial extract significantly reduced IL-8 and GM-CSF mRNA, which induce inflammation of the airway mucosa in human bronchial epithelial cells. In addition, the anti-inflammatory and anti-allergic action of the epidermite extract was studied in many studies, such as it was reported that the secretion of IL-1β and TNF-α in macrophage 2647 cells induced by LPS inflammation was reported.

The above-mentioned Hwangjeong is the dried rhizome of the perennial herb belonging to the Liliaceae, Liliaceae, which contains glucokinin and saponin. , diabetes, anti-aging and skin care. In the present invention, the hwangjeong can be used after being immersed in alcohol for 20 to 30 hours and then steamed in 9 packs and 9 bags.

The Schisandra belongs to the family Magnoliaceae, and the Latin name is Schizandrae Fructus. The Schisandra has an uneven spherical-spherical shape, a diameter of about 6 mm, and a dark red-black brown color. The outer surface is wrinkled and sometimes white powder is embedded. When the flesh is peeled off, 1-2 kidney-shaped seeds with a length of 2-5 mm are contained. The outer surface of the seeds is glossy yellowish-brown-dark red-brown, and there is a clear balm on the back. The outer coat is easy to peel off, but the inner coat is closely attached to the endosperm. The omija has been reported to have the effect of stopping sweating, the effect of quenching thirst, and the effect of improving shortness of breath or coughing because the lungs are empty. In the present invention, the omija may be roasted and used.

The half-lily (Portulaca grandiflora Hooker) is native to South America and is also commonly referred to as cypress flower. Alkaloids, flavonoids, etc. are contained in the forage as an ingredient, and as main ingredients, Portulal, Betanin, Betacyanin, Betanidin, etc. are known. have.

The anti-mutagenicity anti-mutagenicity drug was mainly used for external use, such as sore throat due to its cooling and heat action, bruises and rashes caused by hot water (The Dictionary of Traditional Chinese Medicine, Book Publication Jeongdam, 1997) Activity (antimutagenic effect) (Zhongguo Zhong Yao Za Zhi, 15:617-22, 1990), etc. have been reported, and other antioxidant and anti-inflammatory activity (Patent Registration No. 10-793019), neuroinflammation or degenerative cranial nerve disease prevention or treatment Activity (Patent Publication No. 10-2016-0025415), hair growth promotion or hair loss prevention activity (Patent Publication No. 10-2012-0117128), etc. have been reported.

On the other hand, the health supplement composition using the herbal material according to the present invention is the hyssop, ginseng, baekchul, danang ginseng, maple, mokdanpi, hwangbaek, sukjihwang, hyungsam, texas, hwanggi, casualty, seonmo, faemo, gugija, sangbaekpi, hwangjeong, In addition to the composition consisting of Schisandra and Banchili, it may further include sukjam powder, green tea powder, green-lipped mussel oil and colostrum powder.

Specifically, in the health supplement composition using the herbal material according to the present invention, 1 to 3 parts by weight of the sukjam powder, 2 to 4 parts by weight of seaweed powder, 1 to 3 parts by weight of green lipped mussel oil, and 0.5 to 1.5 parts by weight of colostrum powder may be included.

The sukjam powder prepared by the following method may be used.

In order to prepare the sukjam powder, first, sukjam may be prepared.

The sukjam refers to a silkworm in which the silk protein is contained in the silkworm body until it completely builds a cocoon and molts into a pupa.

In other words, in the case of silkworms that normally sleep on four sides, it is the third day of the fifth instar and the third day of the fifth instar. The silkworm becomes the fifth instar and becomes the third day. After starting, the intestines gradually degenerate, and when they reach 5th instar, 7th to 8th, they are filled with only silk protein, which is called deep sleep.

In general, silkworms are one of the complete metamorphosis insects with a life-long process of waking up from eggs, molting 4 times, building a cocoon, transforming into a silkworm pupa, becoming a moth, laying eggs, and then dying about two weeks later.

In addition, silkworm powder is used for food and medicinal purposes, and interest in silkworm ingredients and pharmacological effects is increasing, and various studies related thereto are being conducted.

In particular, along with the study of blood sugar-lowering active ingredients, it is clinically recommended among patients because it is thought that long-term administration of it for a significant number of patients reduces blood sugar. Therefore, the safety and efficacy of silkworms, which have been used indiscriminately for the treatment of diabetes in the private sector, are being investigated through clinical studies.

Next, after mixing the prepared sukjam and mulberry leaf, it can be steamed by heating with steam.

In general, if you heat (or steam) sukjam in its natural state, the thread gland (silk thread) becomes very hard and difficult to process. At the same time, the thread glands are soft and can be easily processed.

The mulberry leaf contains 50 kinds of ingredients such as glucoside, vitamin C, vitamin B1, vitamin B2, etc. Although the mulberry leaves are heated together with sleep, the scent of the mulberry leaves penetrates into the sleep, so that the miscellaneous odor of the sleep can be removed.

In the above step, the mulberry leaves are mixed in a weight ratio of 1 to 5 parts by weight based on 100 parts by weight of the total sleep sleep, and the heating may be performed with steam at a temperature of 120 to 130° C. for 1 to 3 hours.

Next, the heated and steamed sukjam may be freeze-dried.

In general, as the freeze-drying method, atmospheric freeze-drying and reduced-pressure freeze-drying may be used. In the present invention, in order to reduce the damage to sleep, freeze at a pressure of 0.5 to 3 mmHg and a temperature of -65 to -55° C. for 30 to 50 hours. It can be carried out by drying.

In the above step, if the freeze-drying is performed outside the above range, the moisture contained in the deep sleep may not be sufficiently sublimed or excessive evaporation of moisture may occur, resulting in damage to the sleep, and maintenance of bio/biochemical activity may be difficult. It can be difficult.

Then, the freeze-dried sukjam powder may be prepared by pulverizing the sukjam powder.

The pulverization of the sukjam may be performed by various methods known in the art using a pulverizer.

The green tea powder prepared by the following method may be used.

In order to prepare the green tea powder, first, it can be washed after preparing the green tea.

The green tea ( Salicornia spp. ) is a representative edible and medicinal halophyte that grows wild in Korea as an annual grass of the family Myopodaceae. The green tea has been used as a folk medicine for a long time for vision loss, indigestion, gastrointestinal disease, hepatitis, kidney disease, etc., and has been scientifically proven to have antioxidant, antidiabetic, anticancer, antihypertensive, antihyperlipidemic, and skin whitening effects.

Next, the washed green tea can be immersed in the mixed solution.

In the above step, by immersing the washed green tea in a mixed solution, it is possible to prevent discoloration or easy deterioration of green tea, and the mixed solution may consist of grape juice, lemon juice and bamboo salt water.

In addition, in the above step, the grape juice is good for preventing blood clots and preventing adult diseases such as high blood pressure, arteriosclerosis and heart disease, and helps to improve memory. It is effective in preventing colds, headaches, etc., and the bamboo salt water sterilizes the green tea to prevent easy spoilage.

In addition, the lemon juice and bamboo salt water can prevent the green tea from discoloring over time, and the mixed solution is prepared by mixing 1 part by weight of grape juice, 1 part by weight of lemon juice, and 8 parts by weight of bamboo salt solution, The bamboo salt water may have a concentration of 1 to 3% by weight.

In addition, in the above step, the washed green tea can be immersed in a mixed solution and maintained at a temperature of 20 to 25° C. for 50 to 100 minutes.

Next, after taking out the green tea immersed in the mixed solution, the green tea can be steamed with steam.

In the above step, the green tea impregnated with the components of grape juice, lemon juice and bamboo salt water is mixed with a mixture of cinnamon powder and sugar, and then steamed in a steamer. In the above step, the cinnamon powder and sugar are cinnamon powder 20 to 30 parts by weight and 10 to 20 parts by weight of sugar are mixed, and heated in a steamer with steam at 120 to 140° C. for 20 to 40 minutes and steamed.

In the above step, the cinnamon powder enhances immunity and promotes blood circulation to help prevent vascular diseases, and has food poisoning prevention, sterilization and insecticidal effects, and the sugar enhances the surface gloss and sugar content of immersed green tea, and has an antiseptic effect. Storage can be improved.

Then, it may be dried after grinding the steamed green tea.

In the above step, the drying efficiency of the green tea can be improved by grinding the steamed green tea to a large particle state and then drying. For example, after pulverizing the green tea to a size of 0.5 to 2 mm, the pulverized green tea may be carried out by drying at 25 to 35° C. for 20 to 30 hours.

Next, by pulverizing the dried green tea, green tea powder can be prepared.

In the above step, the dried green tea can be pulverized and pulverized using a known pulverizer.

The green-lipped mussel oil is manufactured using green-lipped mussels (Perna Canaliculus), which is a kind of mussels that inhabit the coast of New Zealand and is called green-lipped mussel, and its scientific name is Perna. Canaliculus.

It has been reported that the green-lipped mussel contains omega unsaturated fatty acids related to antioxidant and anti-inflammatory properties, that is, a unique component that cannot be seen in mussels that are native to other regions, because the green-lipped mussel feeds mainly on plankton that has evolved to resist intense ultraviolet rays.

In addition, the unsaturated fatty acids found in the green lipped mussel have been known through clinical trials to have a 200-fold stronger anti-inflammatory effect than fish oil, linseed oil, evening primrose oil, and the like containing omega-3 fatty acids. Omega-3 fatty acids have been found to inhibit the occurrence of inflammatory diseases such as arteriosclerosis and rheumatoid arthritis by inhibiting the production of inflammatory mediators made from omega-6 fatty acids by competing with omega-6 linoleic acid. there is a bar

As the green-lipped mussel oil, green-lipped mussel oil prepared by the following method may be used.

First, the skin of the green-lipped mussel may be removed, and the green-lipped mussel from which the skin has been removed may be washed.

In the above step, the green-lipped mussel from which the skin has been removed can be washed with a sodium bicarbonate solution having a temperature of 10 to 20° C. and a concentration range of 1 to 3 (w/w)%, and the sodium bicarbonate (NaHCO3) is a food product. It is also used as an additive, is non-toxic, and may have functions such as penetration, diffusion, and expansion.

Next, the washed green-lipped mussels may be dried.

Drying of the washed green-lipped mussel may consist of a first drying and a second drying, wherein the first drying is performed by drying the washed green-lipped mussel at a temperature of 70 to 80° C. for 3 to 5 hours. Residual moisture in green-lipped mussels can be removed primarily.

In addition, in the second drying, the first dried green-lipped mussel may be dried with hot air, and the second drying is performed by applying hot air to the first dried green-lipped mussel at a temperature of 110 to 130° C. for 1 to 3 hours. This can be done by adding

Next, the second dried green-lipped mussel can be pulverized and then aged to prepare an aged green-lipped mussel powder.

In the above step, the grinding of the second dried green-lipped mussel is pulverized by pulverizing the second dried green-lipped mussel to a particle size of 5 to 10 mm, and the aging of the powdered green-lipped mussel is the powdered green mussel. It can be carried out by storing the lipped mussels at a temperature of 5 to 10° C. for 3 to 7 hours.

Then, the green-lipped mussel aged powder can be enzymatically decomposed by mixing the enzyme and acid and storing the mixture.

That is, in the above step, the enzyme and acid are mixed in the aged powder of green lipped mussel, and then the aged powder of green lipped mussel in which the enzyme and acid are mixed is stored at a temperature of 36 to 38° C. for 20 to 30 hours, thereby enzymatic decomposition. .

In the above step, known commercially available protease (Protease), chitinase (chitinase), pectinase (Pectinase) and xylanase (Xylanase) are used as the enzyme, and citric acid and ascortic acid are used as the acid. Binic acid may be used, specifically, 0.01 to 0.03 parts by weight of the protease, 0.03 to 0.05 parts by weight of the chitinase, and pectinase based on 100 parts by weight of the whole aged powder of green lipped mussel. 0.005 to 0.009 parts by weight, 0.008 to 0.012 parts by weight of Xylanase, 0.01 to 0.1 parts by weight of citric acid, and 0.01 to 0.1 parts by weight of ascorbic acid may be mixed in a weight ratio.

Next, the fermented green-lipped mussel can be prepared by mixing the lactic acid bacteria culture solution with the enzyme-decomposed green-lipped mussel aged powder and fermenting it.

In the above step, after mixing in a weight ratio of 1 to 3 parts by weight of the lactic acid bacteria culture solution to 100 parts by weight of the enzyme-decomposed green-lipped mussel aged powder, fermentation may be performed at a temperature of 40 to 42° C. for 20 to 30 hours.

In addition, in the above step, the lactic acid bacteria culture medium was adjusted to pH 2.8 to 3.2 using 1.2N HCl, and then the lactic acid strain was separated from kimchi, and the separated lactic acid strain was used in MRS broth (Oxoid, England). After culturing at 37-39°C for 20-25 hours, dilute to 1×1.0 ^8-5 ×1.0 ⁸ CFU/mL, and then centrifuge at 10,000-15,000 rpm for 10-15 minutes to separate only the supernatant And, after filtering the supernatant (Supernatant) with a 0.45㎛ syringe filter (syringe filter), mixed in a weight ratio of 1,000 to 2,000 parts by weight of sterilized distilled water with respect to 100 parts by weight of the filtered supernatant It is prepared by diluting, the lactic acid bacteria As a lactic acid strain isolated from fermented food, kimchi, specifically, the lactic acid strain includes Lactobacillus curvatus , Weissella viridescens , Lactobacillus plantarum ) and Any one or more known lactic acid strains selected from the group consisting of Leuconostoc lactis may be used.

Next, the green-lipped mussel oil can be prepared by separating the oil using the fermented green-lipped mussel.

The configuration, such as separating the oil using the green-lipped mussel fermented product in the above step, is a known technique to those of ordinary skill in the art, and for convenience of explanation and clarity of the technical idea of the present invention, A detailed description thereof will be omitted.

The colostrum powder is prepared using colostrum, the colostrum refers to the milk that a mammal secretes within one week after delivery, and recently, the milk secreted within 48 to 72 hours after delivery is defined as colostrum.

In general, colostrum secreted within 48 hours contains a large amount of functional substances. Chemically, cow colostrum is a very complex liquid substance, rich in protein, carbohydrate, fat, vitamins, and minerals. It contains a large amount of immunomodulatory factors, physiologically active factors, antibacterial factors, growth hormones, growth factors, and cell division activators, which are involved in the growth of organs and tissues and the development of the immune system.

Substances and factors with these immunological and physiological properties are mainly contained in colostrum whey, and a-lactalbumin and b-lactoglobulin account for 70-80%, and other protein components include serum albumin, lactoferrin, Immunoglobulin, growth factor, lysozyme, trace amount of bioactive factor, etc., many studies are being conducted to characterize each (Korean J. Food Sci. Technol. Vol.34, No.4, pp.694~699 (2002) )).

Studies have shown that atherosclerosis and cardiovascular disease are associated with altered immunity, damage to the heart and blood vessels produces antibodies that further impair the immune system, and in several studies, chlamydia-infectious pneumonia, etc., activate early-stage atherosclerotic lesions. and developmental causes. The immune factors of bovine colostrum help fight this bacteria, and in particular, the proline-rich-polypeptide contained in colostrum is expected to have a myocardial protective effect on patients diagnosed with cardiomyopathy, It suppresses cholesterol deposition in damaged blood vessels by regulating the immune response, and growth factors promote the repair and regeneration of cardiac cells, and the regeneration of new coronary vessels for collateral circulation.

In addition, in relation to blood pressure control function, the peptide present in colostrum lowers blood pressure by inhibiting angiotensin I-converting enzyme (ACE), an enzyme integrally involved in the renin-angiotensin system, thereby lowering blood pressure and reducing cardiac oxygen consumption. It has been reported as a result of research that it has antihypertensive and cardiovascular disease improvement effects by reducing

In a recent study in a rat model of myocardial infarction, after 28 days of ingestion of colostrum, the protective efficacy of cardiac tissue damage was observed through inhibition of lipid peroxidation (antioxidant) and reduction of cardiac damage markers (CKMB, LDH). It was confirmed that the efficacy was further enhanced when combined with therapeutic agents (ACE inhibitors, blood pressure regulator enalapril) (Journal of pharmacology and toxicology 9(1):37-45, 2014).

In addition, the colostrum contains Insulin-like Growth Factor-1 (IGF-1), which promotes overall growth and is known to have the ability to regulate cell growth and amplification.

In the present invention, the colostrum powder prepared by the following method may be used as the colostrum powder.

In order to prepare the colostrum powder, first, prepare bovine colostrum, mix the enzyme with the prepared bovine colostrum, and store it for enzymatic decomposition.

That is, in the step, after mixing the enzyme with the prepared bovine colostrum, the enzyme-mixed bovine colostrum can be enzymatically decomposed by storing it at a temperature of 36 to 38° C. for 20 to 30 hours.

In the above step, as the enzyme, a commercially available protease and xylanase may be used, for example, as the protease, chymotrypsin may be used and , The chymotrypsin is a digestive enzyme that causes protein degradation.

That is, the chymotrypsin is a digestive enzyme that causes protein degradation and breaks the peptide bond, and the chymotrypsin acts as a protease in the digestive system of mammals and other organisms. The chymotrypsin substrate includes tryptophan, tyrosine, phenylalanine, leucine, and methionine, and their carboxy terminus is cut off. Like other proteolytic enzymes, it triggers a reaction that breaks peptide bonds.

In addition, the xylanase (Xylanase) is an enzyme that hydrolyzes xylan into xylo-oligosaccharide or xylose, and is an enzyme used in bioenergy, food, fiber, paper and pulp industries. to be. Research is being actively conducted in the field of bioethanol production by decomposing and saccharifying vegetable fiber, the most abundant biological resource on the planet, and the production of high-quality paper and waste paper recycling, removal of turbidity in fruit drinks and beer, and the production of coffee, vegetable oil and starch. It is an enzyme that is already widely used industrially for purposes such as extraction and increasing the efficiency of feed use of unit animals.

Specifically, in the above step, the enzyme is mixed in a weight ratio of 0.01 to 0.03 parts by weight of a protease such as chymotrypsin and 0.008 to 0.012 parts by weight of xylanase with respect to 100 parts by weight of the prepared bovine colostrum. can be

Next, the enzyme-decomposed bovine colostrum may be mixed with a culture broth and a fermentation broth consisting of lactic acid bacteria.

In the above step, as the lactic acid bacteria, any one known lactic acid bacteria selected from the group consisting of Lactobacillales , Streptococcus thermophiles and Bifidobacterium longum may be used, and the The culture medium consists of peptone, malt extract, sodium citrate, potassium phosphate dibasic, glucose and distilled water, and the culture medium is 15 to 25 parts by weight of peptone, malt extract 5 to 15 parts by weight, 0.5 to 1.5 parts by weight of sodium citrate, 0.1 to 0.3 parts by weight of potassium dibasic phosphate, 1 to 3 parts by weight of glucose, and 100 to 200 parts by weight of distilled water may be mixed in a weight ratio.

In the culture medium, the peptone is a nitrogen source that supplies proteins and supplies proteins necessary for the growth of microorganisms, and the malt extract contains various minerals, vitamin B group, and amino acids to help microorganisms grow, Silver is a mineral that maintains an optimal state for the growth of microorganisms by adjusting the pH of the culture medium, and can supply nutrients, and the glucose can function as an important component for lactic acid bacteria to metabolize sugar to produce organic acids.

Next, it is possible to prepare a fermented bovine colostrum by fermenting the bovine colostrum mixed with the fermentation broth.

In the above step, the fermentation may be performed by storing the bovine colostrum mixed with the fermentation broth at a temperature of 38 to 42° C. for 1 to 3 days.

Then, the fermented bovine colostrum is filtered to remove impurities, freeze-dried, and then pulverized to prepare colostrum powder.

In the above step, impurities remaining in the fermented bovine colostrum can be removed by filtering the fermented bovine colostrum using a known filter, and the filtered fermented bovine colostrum at a temperature in the range of -40°C to -30°C After freeze-drying for 1 to 3 hours, it can be pulverized to prepare colostrum powder.

Hereinafter, a preferred embodiment of the health supplement using the herbal material according to the present invention will be described in more detail.

Health supplements using herbal medicines according to the present invention are hyssop, ginseng, baekchul, dang ginseng, maple, mulberry, hwangbaek, sukjihwang, hyeonsam, taeksa, hwanggi, casualty, seonmo, faemo, gugija, sangbaekpi, hwangjeong, omija, and banjo lily. It can be prepared by pulverizing the composition consisting of to prepare herbal powder, fermenting the herbal powder with Hong Guk-gyun, and then molding it into powder, granules, tablets, capsules, beverages or extracts.

The Hong Guk-gyun (Monascus sp.) is a kind of yeast mold containing a red pigment, and is a fungus that exhibits excellent effects such as blood pressure, blood sugar lowering, antibacterial, anticancer, and cholesterol lowering. In addition, the Hong Guk-gyun is used as an eohyeol reliever in oriental medicine and is known to secrete a substance called monacolin-K, which is effective in lowering blood pressure and decomposes cholesterol.

In the present invention, the herbal medicine powder can be fermented using known honggukgyun commercially available, for example, by mixing the herbal medicine powder and honggukgyun and fermenting at a temperature of 60 to 70° C. for 20 to 50 hours. can proceed.

Hereinafter, it will be described in more detail by giving examples of the health supplement using the herbal material according to the present invention.

< Example 1 >

First, 5 parts by weight of hyssop, 5 parts by weight of ginseng, 5 parts by weight of baekchul, 5 parts by weight of ginseng, 5 parts by weight of maple, 5 parts by weight of mulberry skin, 5 parts by weight of hwangbaek, 5 parts by weight of red ginseng, 5 parts by weight of ginseng, texas 5 Mixed in parts by weight, 5 parts by weight of Astragalus, 5 parts by weight of casualties, 5 parts by weight of Seonmo, 5 parts by weight of Peamo, 5 parts by weight of Goji berry, 5 parts by weight of sangbaekpi, 5 parts by weight of Hwangjeong, 5 parts by weight of Schisandra, and 5 parts by weight of banyan tree. Herbal medicine powder was prepared by pulverizing the herbal medicine, and after mixing the herbal medicine powder and Hong Guk-gyun, it was fermented at a temperature of 65° C. for 35 hours.

Then, the fermented herbal powder was extracted to prepare an extract in which useful herbal ingredients were extracted, and by separating and removing solids from the extract, a liquid extract containing useful herbal ingredients was prepared.

< Example 2 >

A liquid extract was prepared using the same composition as in Example 1, and in Example 2, 2 parts by weight of sukjam powder, 3 parts by weight of seaweed powder, 2 parts by weight of green lipped mussel oil, and 1 part by weight of colostrum powder were further included as herbal medicines. .

Experimental Example 1. Toxicity test

This experiment was carried out to investigate the toxicity of the liquid extracts of Examples 1 and 2 to the animal body acutely (within 24 hours) when ingested in excess in a short period of time, and to determine the mortality rate. Thirty ICR mouse strains, which are general mice, were assigned to the control group and the experimental group by 10 mice each. The control group was administered with only PEG-400/tween-80/EtOH (8/1/1, v/v/v), and the experimental group received the liquid extracts of Examples 1 and 2 of the present invention with the PEG-400/tween-80 It was dissolved in /EtOH (8/1/1, v/v/v) and administered orally, respectively. As a result of examining each mortality rate 24 hours after administration, it was confirmed that all mice survived in the control group and the experimental group administered with the liquid extracts of Examples 1 and 2 of the present invention at a concentration of 2 g/kg/day.

Experimental Example 2. Cytotoxicity evaluation test (MTT assay)

TM3 (BALB/c ^nu/+ mouse) was acquired from the Korea Cell Line Bank and used in the experiment. As a medium, 10% FBS and 1% penicillin/streptomycin were added to DEME, and cultured for 24 hours at 37° C., 5% CO ₂ condition in the medium was used for the experiment.

TM3 cells were placed in a 96-well plate so as to become 2x10 ⁴ cells/well, and incubated in an incubator at 37° C., 5% CO ₂ conditions for 12 hours. After 12 hours, all of the medium was discarded, and Example 1 was diluted with a stock solution, 10 times, 30 times, and incubated for 24 hours at 37°C, all of the medium was discarded and MTT (Thiazoly blue tetrazolium bromide, 1 mg/ml) reagent was added. It was cultured in the containing medium for 4 hours. After discarding all of the medium and adding 200ul of DMSO, the intracellular formazan crystal was dissolved, and the absorbance was measured at an absorbance of 570 nm, and the results are shown in FIG. 1 . Control means a distilled water treatment group treated with distilled water instead of Example 1.

1 is a graph showing the cytotoxicity results through the MTT assay for the liquid extract of Example 1.

Referring to FIG. 1 , it can be seen that the stock solution of Example 1 was diluted 10 times and 30 times and there was no cytotoxicity at all concentrations.

Experimental Example 3. Efficacy evaluation test related to male hormone synthesis (in vitro test)

The degree of change in testosterone for TM3 cells according to the treatment of Example 1 was tested. Standard made standards of 0, 1.95, 7.81, 31.25, 125, 500, and 2000 pg/ml of 50,000 pg/ml testosterone provided as a kit using phosphate buffer saline (PBS). The assay buffer was diluted to 1:10 using high-purity distilled water, and the wash buffer was diluted to 1:20 using high-purity distilled water. The measurement method is to put 1×10 ⁶ cells/well of cells in a 6-well plate, incubate them for 12 hours at 37°C and 5% CO ₂ , attach the cells to the bottom of the well plate, discard all the medium, and add the stock solution, The liquid extract of Example 1 diluted 10-fold and 30-fold was put in the same volume and cultured for 24 hours at 37° C. and 5% CO ₂ , and then the medium was recovered and testosterone was measured. That is, 100 μl of the recovered medium was transferred to a goat anti-mouse IgG microtiter plate (assay designs, USA), and incubated for 1 hour after addition of testosterone EIA antibody. After the incubation was completed, it was washed with wash buffer, and after washing, a stop solution was added, the reaction was stopped, and the absorbance was measured at 405 nm using a microplate reader. The experimental results are shown in FIG. 2 . Control means a distilled water treatment group treated with distilled water instead of Example 1.

Figure 2 is a graph showing the testosterone (testosterone) hormone activity evaluation results of the liquid extract of Example 1.

Referring to FIG. 2 , it can be seen that the testosterone level increased by about 2.3 times when Example 1 was treated with the stock solution compared to the control, and the testosterone hormone level increased even when diluted 10 times and 30 times.

Experimental Example 4. Sensory evaluation

30 ml of the liquid extract of Example 1 was taken with water in an evaluation group consisting of 40 adults and men, and the convenience of taking was sensory evaluated based on a 5-point scale according to each item below, and the results are shown in Table 1 below. (1: very bad, 2: bad, 3: average, 4: good, 5: very good)

division result taste 4.4 incense 4.6 throat swallow 4.3 overall sign 4.4

Referring to [Table 1], it can be confirmed that the liquid extract of Example 1 has excellent sensory properties such as taste, aroma, throat swallowing, and preference.

As described above, a preferred embodiment of the present invention has been described, but those of ordinary skill in the art to which the present invention pertains will understand that the present invention may be embodied in other specific forms without changing the technical spirit or essential features thereof. will be able Therefore, it should be understood that the embodiment described above is illustrative in all respects and not restrictive.

Claims (6)

delete delete Herbal medicine powder was prepared by pulverizing a composition consisting of hyssop, jimo, baekchul, dang ginseng, maple, mokdan skin, hwangbaek, sukjihwang, hyeonsam, taeksa, hwanggi, casualty, seonmo, paemo, gugija, sangbaekpi, hwangjeong, omija, and half lily. , produced by fermenting the herbal powder with Honggukgyun,
5 parts by weight of the hyssop, 5 parts by weight of ginseng, 5 parts by weight of baekchul, 5 parts by weight of ginseng, 5 parts by weight of maple, 5 parts by weight of mulberry skin, 5 parts by weight of hwangbaek, 5 parts by weight of red ginseng, 5 parts by weight of ginseng, and 5 parts by weight of ginseng In a weight ratio of parts, 5 parts by weight of Astragalus, 5 parts by weight of casualties, 5 parts by weight of Seonmo, 5 parts by weight of balsam, 5 parts by weight of Goji berry, 5 parts by weight of sangbaekpi, 5 parts by weight of Hwangjeong, 5 parts by weight of omija and 5 parts by weight of banyan tree. included,
The fermentation proceeds by mixing the herbal medicine powder and Hong Guk-gyun and fermenting for 20 to 50 hours at a temperature of 60 to 70 ℃,
In addition to the composition consisting of the hyssop, jimo, baekchul, dang ginseng, maple, muldanpi, hwangbaek, sukjihwang, hyeonsam, taeksa, hwanggi, casualty, seonmo, paemo, gugija, sangbaekpi, hwangjeong, omija and half lily, sukjam powder, green tea powder , further comprising green-lipped mussel oil and colostrum powder, 2 parts by weight of the sukjam powder, 3 parts by weight of seaweed powder, 2 parts by weight of green-lipped mussel oil and 1 part by weight of colostrum powder,
The sukjam powder is prepared by preparing sukjam, mixing the prepared sukjam and mulberry leaves, and then heating them with steam to steam, the mulberry leaves are mixed in a weight ratio of 1 to 5 parts by weight based on 100 parts by weight of the total sukjam, and the heating is It is carried out for 1 to 3 hours with steam at a temperature of 120 to 130 ℃, freeze-dried for 30 to 50 hours at a pressure of 0.5 to 3 mmHg and a temperature of -65 to -55 ℃ of the heated and steamed sukjam, the freeze-dried It is manufactured through the process of pulverizing and pulverizing the
The green tea powder, after preparing the green tea, is washed, and the washed green tea is mixed in a weight ratio of 1 part by weight of grape juice, 1 part by weight of lemon juice and 8 parts by weight of bamboo salt solution in a mixed solution at a temperature of 20 to 25 ° C. 50 to 100 Soaked for minutes, the bamboo salt water has a concentration of 1 to 3% by weight, and after taking out the green tea immersed in the mixed solution, the green tea is mixed with a mixture of cinnamon powder and sugar, and steamed in a steamer, but the cinnamon powder and Sugar is mixed in a weight ratio of 20 to 30 parts by weight of cinnamon powder and 10 to 20 parts by weight of sugar, heated in a steamer at 120 to 140° C. with steam for 20 to 40 minutes and steamed, and the steamed green tea is 0.5 After pulverizing to a size of 2 mm, the pulverized green tea is dried at 25 to 35 ° C. for 20 to 30 hours, and is manufactured through a process of pulverizing and pulverizing the dried green tea,
The green-lipped mussel oil removes the skin of the green-lipped mussel, and washes the peeled green-lipped mussel at a temperature of 10 to 20° C. and a sodium bicarbonate solution having a concentration range of 1 to 3 (w/w)%. and drying the washed green-lipped mussels, wherein the drying consists of a first drying and a second drying, and the first drying is the first drying of the washed green-lipped mussels at a temperature of 70 to 80° C. for 3 to 5 hours. The second drying is performed by applying hot air at a temperature of 110 to 130° C. to the first dried green lipped mussel for 1 to 3 hours, and the second dried green lipped mussel to a particle diameter of 5 to 10 mm. After grinding and pulverization, it is aged at a temperature of 5 to 10° C. for 3 to 7 hours to prepare an aged green-lipped mussel powder, and an enzyme and an acid are mixed with the aged green-lipped mussel powder at a temperature of 36 to 38°C. Stored for 20 to 30 hours and enzymatically decomposed, the enzyme is protease, chitinase, pectinase and xylanase are used, and the acid is citric acid and ascorbic acid It is used, and based on 100 parts by weight of the whole aged powder of green lipped mussel, 0.01 to 0.03 parts by weight of the protease, 0.03 to 0.05 parts by weight of chitinase, 0.005 to 0.009 parts by weight of pectinase, xyl Lanase (Xylanase) 0.008 to 0.012 parts by weight, citric acid 0.01 to 0.1 parts by weight, and ascorbic acid mixed in a weight ratio of 0.01 to 0.1 parts by weight, lactic acid bacteria culture medium 1 to 100 parts by weight of the enzyme-decomposed green lipped mussel aged powder After mixing in a weight ratio of 3 parts by weight, fermentation was carried out at a temperature of 40 to 42° C. for 20 to 30 hours to prepare a fermented green lipped mussel, but the lactic acid bacteria culture medium was pH 2.8 to 2.8 using 1.2N HCl. After adjusting to 3.2, a lactic acid strain was isolated from kimchi, and the isolated lactic acid strain was MR After culturing for 20 to 25 hours at 37-39°C using S broth (Oxoid, England), it is diluted to 1×1.0 ⁸ to 5×1.0 ⁸ CFU/mL, and then at 10,000 to 15,000 rpm for 10 to 15 minutes. After centrifugation to separate only the supernatant, the supernatant is filtered with a 0.45 μm syringe filter, and then mixed in a weight ratio of 1,000 to 2,000 parts by weight of sterilized distilled water with respect to 100 parts by weight of the filtered supernatant. It is prepared by diluting, and is manufactured through a process of separating oil using the fermented green-lipped mussel,
The colostrum powder is enzymatically decomposed by preparing bovine colostrum, mixing the enzyme with the prepared bovine colostrum, and storing the enzyme-mixed bovine colostrum at a temperature of 36 to 38 ° C. for 20 to 30 hours. With respect to 100 parts by weight of the prepared whole bovine colostrum, protease (Protease) 0.01 to 0.03 parts by weight and xylanase (Xylanase) in a weight ratio of 0.008 to 0.012 parts by weight, the enzyme-decomposed bovine colostrum fermentation broth consisting of a culture solution and lactic acid bacteria However, as for the lactic acid bacteria, any one lactic acid bacteria selected from the group consisting of lactic acid bacteria ( Lactobacillales ), Streptococcus thermophiles and Bifidobacterium longum is used, and the culture medium is peptone 15 to 25 parts by weight, 5 to 15 parts by weight of malt extract, 0.5 to 1.5 parts by weight of sodium citrate, 0.1 to 0.3 parts by weight of dibasic potassium phosphate, 1 to 3 parts by weight of glucose, and 100 to 200 parts by weight of distilled water. and fermenting the bovine colostrum mixed with the fermentation broth at a temperature of 38 to 42° C. for 1 to 3 days to prepare a fermented bovine colostrum, filtering the fermented bovine colostrum to remove impurities, and the filtered bovine colostrum It is prepared by freeze-drying the fermented product at a temperature of -40°C to -30°C for 1 to 3 hours and then pulverizing,
A health supplement using herbal medicine, characterized in that the extract is prepared by extracting the herbal medicine powder fermented with the Hong Guk-gyun, and the solid content is separated and removed from the extract to prepare a liquid extract. delete delete delete

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