KR101010575B1 - The composition for the atopic dermatitis improving with vinegar - Google Patents

Abstract

The present invention relates to a composition for improving atopic skin disease containing persimmon vinegar.

The composition of the present invention, persimmon vinegar 10 to 40% by weight, evening primrose oil 40 to 80% by weight, natural wax 1 to 20% by weight, tannin 1 to 10% by weight, ascorbic acid 1 to 10% by weight, natural It contains 0.01 to 0.5% by weight of oil.

By this invention, the composition which shows the outstanding improvement effect with respect to atopic skin disease is provided.

Persimmon vinegar, atopic, skin disease, improvement, composition

Description

Composition for improving atopic dermatological disease containing persimmon vinegar {TH COMPOSITION FOR THE ATOPIC DERMATITIS IMPROVING WITH VINEGAR}

The present invention relates to a composition for improving atopic skin disease prepared using natural ingredients such as persimmon vinegar and natural wax.

Atopic (atopic) is one of the factors that cause asthma, high fever, allergic rhinitis, atopic dermatitis and the like easily forms an immune substance (immunoglobulin-E) that causes an allergic reaction.

Among them, atopic dermatitis is a common skin disease, about 10-15% of children have atopic dermatitis, and 75% of patients develop before 1 year of age.

Fever refers to atopic dermatitis in babies under one year of age, usually disappearing when walking, and eczema is confined to the face and neck.

However, even after one year, symptoms do not improve and eczema spreads from the face, neck, torso and limbs, resulting in atopic dermatitis.

That is, about 90% of children's patients improve on their own within five years, and about 5% of patients continue to grow up as adults.

Treatment of atopic dermatitis is aimed at various aspects, such as reducing itching and rashes, controlling the severity and recurrence of seizures, and educating self-care techniques.

In general, it is treated using a topical or moisturizing agent according to the symptoms, but recently, a new immunosuppressant or modulator treatment is used.

Currently, topical anti-inflammatory drugs such as steroids and antihistamines, which are used for the treatment of atopic dermatitis, are used as the most effective drugs for allergic diseases because they have strong immunosuppressive effects. Symptoms such as insomnia and insomnia, and antihistamines are also limited because of side effects such as gastrointestinal irritation, headaches, and blurred vision.

As the side effects of steroids are widely known, therapeutic agents are being developed to replace them. Currently available tacrolimus and pimeolimus can be applied to the skin without serious side effects. It is known to be effective.

However, the sudden worsening of atopic dermatitis has a disadvantage that it is not as effective as steroids, and UV therapy, which is used when systemic atopic dermatitis is severe, is used in combination with other therapies when systemic administration of the drug is difficult or when side effects are severe. , Prolonged use of the skin increases the risk of premature aging and cancer, including burns, itching and pigmentation.

Therefore, the development of a new atopic dermatitis treatment is urgently needed, and many studies have been conducted using various natural materials for the purpose of preventing and treating such atopic dermatitis.

Korean Patent Publication No. 10-0597202 "A composition for improving athlete's foot and atopic dermatitis, cosmetic lotion and drink" contains wood vinegar, aloe and cucumber juice, which is effective in improving skin diseases such as athlete's foot and atopic dermatitis. It is disclosed about the composition which represents.

Korean Patent Application Publication No. 10-0454752 “Functional Food for Atopic Dermatitis” discloses atopic dermatitis therapeutic foods, which include water extracts and salts of celadon leaf and purplish red leaf.

As described above, although a variety of natural materials have been studied for the purpose of preventing and treating atopic dermatitis, the composition for improving atopic dermatitis containing persimmon vinegar has not been studied until now.

In order to solve the above problems, an object of the present invention is to provide a composition that exhibits an excellent improvement effect on atopic skin diseases without skin problems.

The composition for improving atopic dermatological diseases containing persimmon vinegar of the present invention, the persimmon vinegar 10 to 40% by weight, evening primrose oil 40 to 80% by weight, natural wax 1 to 20% by weight, tannin 1 to 10% by weight of the total composition , 1 to 10% by weight of ascorbic acid, 0.01 to 0.5% by weight of natural oil is contained.

The inventor of the present invention has undergone numerous trials and errors in order to invent a composition having an excellent improvement effect on atopic skin diseases without generating skin troubles, and has completed the present invention after a long study.

The main ingredient used in the present invention is vinegar (Vinegar) is a vinegar made by ripening persimmon, contains abundant tannins and ascorbic acid (vitamin C) to reduce the acid concentration of food to increase the preservation power, secretion of digestive juice through sour taste It stimulates the taste buds, is known to have a feature that quickly recovers fatigue by participating in the body's energy metabolism.

Evening primrose seed oil, another material used in the present invention ( Oenothera) odorata ) means the oil from the seeds of the evening primrose oil, which contains 67.5% linoleic acid, 7.5% gamma linolenic acid and 7.5% other fatty acids.

In particular, gamma-linolenic acid contained in this evening primrose oil is a substance in which linoleic acid, which is ingested in general foods, is converted by a specific enzyme, and modern people cannot convert it easily due to wrong eating habits such as eating processed foods, binge eating, smoking, and excessive drinking. As the balance of physiological activity is broken and causes various diseases, you should take gamma-linolenic acid directly.

Evening primrose seed oil relieves PMS (physiological syndrome) associated with women's health, maintains atopic dermatitis and skin health, contains physiologically active substances, and is known to help improve cholesterol and improve blood.

In the present invention, as a result of several experiments to produce a material exhibiting an excellent improvement effect on atopic skin diseases, by mixing the persimmon vinegar with Evening Primrose oil having the above-mentioned effect when used in atopic skin diseases It was confirmed that the.

At this time, persimmon vinegar is 10 to 40% by weight relative to the total weight of the composition, Evening Primrose oil is the most economically suitable when mixed with 40 to 80% by weight relative to the total weight of the composition, showing a high improvement effect on atopic skin diseases.

On the other hand, the inventor of the present invention, when used in atopic skin diseases using only the persimmon vinegar and evening primrose seed oil showing a high effect on the atopic skin disease as described above, a high improvement effect, but the problem that skin problems are generated I found out.

A number of studies have been conducted with various natural ingredients to resolve this problem. When using the natural wax, natural oils, tannins, and ascorbic acid together with persimmon vinegar and evening primrose oil to produce a composition, no skin problems are produced. It was found that the composition can be produced showing a high improvement effect on the disease.

Thus, in the present invention, one wax selected from beeswax wax, calendula wax and olive oil wax is used as natural wax.

Beeswax (Beeswax) is a bakery's release agent and coating material. Bees secrete beeswax from the abdominal lead wire to make a hexagonal arrangement of houses that store honey from flowers in the house. Squeezing the honey in and then refining the rough coarse beeswax is called beeswax.

Beeswax is effective as a chewing gum-based plasticizer, gives flexible texture to chewing gum, and creates a gloss and uniform coating. It is also used as a coating agent for confectionery and sugar foods. It is also known to be used for beeswaxing.

Calendula infused Wax is an oil made by infusing organic calendula petals in sunflower seed oil, and it is effective in repairing damaged skin, healing of wounds, moisturizing and alleviating various skin diseases, and especially for atopic dermatitis. It is known to have.

Olive emulsifying wax (sorbitan olivate) is an emulsifier made by esterifying olive oil. It is excellent for moisturizing oils and is an emollient (skin softening) that spreads and penetrates. It is a stable emulsifier that does not cause allergies. It is known to be used as an emulsifier for.

Tannin is a white or light brown powdered compound derived from astringent plant components that have the skin-derived tanning properties of animal skins, and is known to be widely distributed in less ripe fruits and seeds.

It is most commonly used as a hide, and is also used as a dye for ink or ink, or as a pharmaceutical.

Ascorbic acid is a vitamin fortifying agent in foods that helps collagen synthesis, act as an antioxidant, absorption of iron in the small intestine, and is involved in carnitine biosynthesis and immune function.It is also effective in preventing milk powder and food from oxidation, maintaining freshness, color aid, and discoloration. It is used for fruit juice, canned fruit and jam, and is mainly used for antioxidant of beer and prevention of discoloration of raw meat.

It also has the name Vitamin C, which acts as a reducing agent, helps collagen synthesis, acts as an antioxidant, helps the absorption of iron from the small intestine, and is involved in the biosynthesis and immune function of carnitine.

The present invention is to prepare a composition with persimmon vinegar and evening primrose oil with natural ingredients exhibiting the above-mentioned efficacy, wherein natural wax is 1 to 20% by weight relative to the total weight of the composition, tannin is 1 to 10% by weight relative to the total weight of the composition, Ascorbic acid is economically suitable to be prepared by adding 1 to 10% by weight relative to the total weight of the composition, and also shows the efficacy well.

In addition, in the present invention, natural oil is also used together. As the natural oil used in the present invention, at least one selected from lavender oil, rice bran oil, and carrot oil is used.

At this time, natural oil is used by adding 0.01 to 0.5% by weight relative to the total weight of the composition.

Lavender oil is known to be effective in the treatment of skin infections such as inflammation, acne and wounds as well as insomnia and tension relief.

Rice bran oil (rice bran oil) contains abundant vitamin E and minerals, and is known to be excellent in moisturizing and whitening effects.

Carrot oil is orange in color and contains beta-carotene, vitamins A, B, C, D, E and fatty acids.

As described above, only natural materials having little irritation can be used to alleviate skin troubles such as itching that may occur when used on the skin, and have been found to exhibit excellent effects on atopic skin diseases.

As described above, the inventors of the present invention may be very useful in the composition for improving atopic dermatitis as described above for food additives and beverage compositions.

According to the present invention, there is provided a composition which exhibits an excellent improvement effect on atopic skin diseases without causing skin troubles.

Hereinafter, the composition for improving atopic dermatological diseases containing persimmon vinegar of the present invention will be described in more detail through Examples and Experimental Examples, but these are not intended to limit the scope of the present invention.

Example 1 Preparation of a composition for improving atopic skin disease containing persimmon vinegar of the present invention 1

Persimmon vinegar, evening primrose oil, beeswax wax, calendula wax, olive oil wax, tannin, ascorbic acid and lavender oil were each purchased on the market.

Among them, 25 g persimmon vinegar, evening primrose oil 50 g, beeswax wax 2 g, calendula wax 2 g, olive oil wax 2 g, tannin 9.25 g, ascorbic acid 9.25 g, lavender oil 0.5 g to improve atopic dermatitis A composition for preparation was prepared.

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<Example 4> Preparation of the composition for improving atopic skin disease containing persimmon vinegar of the present invention 4

Persimmon Vinegar, Evening Primrose Oil, Beeswax Wax, Calendula Wax, Olive Oil Wax, Tannin, Ascorbic Acid, Lavender Oil, Lavender Oil, Rice Pomegranate, and Carrot Oil were purchased on the market.

Among the ingredients prepared, persimmon vinegar 10 g, evening primrose oil 65 g, beeswax wax 2 g, calendula wax 2 g olive oil wax 2 g, tannin 9.25 g, ascorbic acid 9.25 g, lavender oil 0.2 g, rice bran 0.1 g, carrot oil 0.1 Mixing g to prepare a composition for improving atopic skin disease.

<Example 5> Preparation of a capsule using the composition for improving atopic skin disease of the present invention

300 mg of atopic dermatitis improvement composition of Example 1

3 mg of crystalline cellulose

Lactose 14.8 mg

Magnesium Stearate 0.2 mg

According to a conventional capsule preparation method, the above ingredients were mixed and filled into gelatin capsules to prepare capsules.

<Example 6> Preparation of a liquid formulation using the composition for improving atopic skin disease of the present invention

300 mg of atopic dermatitis improvement composition of Example 1

10 g per isomer

5 g mannitol

Purified water quantity

According to the conventional method of preparing a liquid solution, each component is added to the purified water to dissolve, the lemon flavor is added appropriately, the above components are mixed, purified water is added, the whole is adjusted to 100 ml by the addition of purified water, and then filled into a brown bottle. The solution was prepared by sterilization.

<Example 7> Preparation of health food using the composition for improving atopic skin disease of the present invention

1000 mg of composition for improving atopic skin disease of Example 1

Vitamin mixture quantity

70 μg of Vitamin A Acetate

Vitamin E 1.0 mg

Vitamin B1 0.13 mg

Vitamin B2 0.15 mg

Vitamin B6 0.5 mg

0.2 μg of vitamin B12

Vitamin C 10 mg

10 μg biotin

Nicotinic Acid 1.7 mg

50 μg folic acid

Calcium Pantothenate 0.5mg

Mineral mixture

Ferrous Sulfate 1.75 mg

Zinc Oxide 0.82 mg

Magnesium carbonate 25.3 mg

Potassium monophosphate 15 mg

Dibasic calcium phosphate 55 mg

Potassium Citrate 90 mg

Calcium Carbonate 100 mg

Magnesium chloride 24.8 mg

Although the composition ratio of the above-mentioned vitamin and mineral mixtures is mixed with a component suitable for a health food in a preferred embodiment, the compounding ratio may be arbitrarily modified, and the above ingredients are mixed according to a conventional health food manufacturing method. Granules were prepared, and a health food composition was prepared according to a conventional method.

<Example 8> Preparation of health drink using the composition for improving atopic skin disease of the present invention

1000 mg of composition for improving atopic dermatosis of Example 1

Citric acid 1000 mg

100 g oligosaccharides

Plum concentrate 2 g

1 g of taurine

Add 900 ml of purified water

After mixing the above components in accordance with the conventional healthy beverage production method, and stirred and heated at 85 ℃ for about 1 hour, the resulting solution is filtered and obtained in a sterilized 2 L container, sealed, sterilized and refrigerated Next, the health beverage composition of the present invention was prepared.

Although the compositional ratio is relatively mixed with a component suitable for a favorite drink, it is also possible to arbitrarily modify the compounding ratio according to the regional or national preference such as the demand class, the demanding country, and the use purpose.

Comparative Example 1 Composition for Atopic Skin Disease 1

Prepared in the same manner as in Example 1, but the composition was prepared without adding persimmon vinegar.

That is, 75 g of evening primrose oil, beeswax wax 2 g, calendula wax 2 g, olive oil wax g, tannin 9.25 g, ascorbic acid 9.25 g, lavender oil 0.5g was mixed to prepare a composition.

<Comparative Example 2> Composition for atopic skin disease 2

A composition was prepared by mixing only 25 g of persimmon vinegar and 75 g of evening primrose oil.

Experimental Example 1 Skin Condition Change Experiment

The compositions of Examples 1 and 4 and Comparative Examples 1 and 2 of the present invention were prepared.

Forty patients with about 60% of atopic dermatitis, the composition of Examples 1 to 4 of the present invention and the compositions of Comparative Examples 1 to 2 were applied to the atopic dermatitis site three times daily.

After 1 month, the degree of atopic skin improvement was confirmed.

The results are shown in Table 1 below.

term Example 1 Example 4 Comparative Example 1 Comparative Example 2 0 days 0 % 0 % 0 % 0 % 1 week later 25% 31% 6% 20% after 2 weeks 44% 55% 10% 45% 4 weeks later 80% 85% 40% 80% Skin trouble Do not create Do not create Do not create produce

As shown in Table 1, a week after applying the composition of the present invention Examples 1 to 4 it was confirmed that the atopic dermatitis area gradually disappeared, it was confirmed that no skin trouble is generated (Fig. 1, 2).

After 4 weeks, all the people who applied the composition of the present invention showed an improvement effect on at least 80% of atopic dermatitis.

However, those who applied the composition of Comparative Example 1 obtained only about 40% improvement, and the composition of Comparative Example 2 showed a high improvement effect, but it was confirmed that the skin trouble was generated.

1 is a photograph showing a state of atopic skin disease after applying the composition of Example 1 of the present invention for 1 week.

A: Arm before applying

B: arm after 1 week

Figure 2 is a photograph showing the state of atopic skin disease after applying the composition of Example 1 of the present invention for 4 weeks.

A: Leg before applying

B: 2 weeks after the leg

C: leg after 4 weeks

Claims (3)

Persimmon vinegar 10 to 40% by weight, evening primrose oil 40 to 80% by weight, natural wax 1 to 20% by weight, tannin 1 to 10% by weight, ascorbic acid 1 to 10% by weight, natural oil 0.01 to 0.5% by weight A composition comprising A pharmaceutical composition for treating atopic dermatitis applied to atopic dermatitis. The method of claim 1, Natural wax is characterized by consisting of one or more selected from beeswax wax, calendula wax, olive oil wax, A pharmaceutical composition for treating atopic dermatitis applied to atopic dermatitis. The method of claim 1, Natural oil is characterized by consisting of one or more selected from lavender oil, rice bran oil, carrot oil, A pharmaceutical composition for treating atopic dermatitis applied to atopic dermatitis.

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