RU2270583C2 - Biologically active food supplement for vision correction and prophylaxis of vision distortion - Google Patents

Abstract

FIELD: bioactive food supplements with prophylaxis effects.

SUBSTANCE: claimed biologically active food supplement contains (mass %): dehydrated bilberry fruit powder 15.0-53.0; dry ginkgo biloba extract 10.0-30.0; fine dispersed powder of dry ginkgo biloba leaves 10.0-40.0; magnesium and/or calcium stearate 0.3-1.0; and balance to 100 %: starch and/or fine-grade cellulose. Supplement of present invention has antiinflammation action, stabilizes capillaries, prevents free radical harmful action on visual organs.

EFFECT: enhanced assortment of agent for vision correction and prophylaxis of vision distortion.

2 cl, 2 ex

Description

The invention relates to medicine, namely to biologically active food supplements, intended for the preventive effect of both the body as a whole and the functioning of its individual organs and systems.

Currently, there has been significant interest in the development of therapeutic and prophylactic effects on human vision using natural products. This is largely determined by the development of technological progress, the results of which in some cases lead to poor vision and, consequently, a decrease in the quality of human life. This is due to various kinds of environmental violations, unbalanced nutrition, etc. For example, the rapid development of computer technology has led to the need for long-term work with video terminals, which leads to eye fatigue, excessive overload, etc. The harmful effects of free radicals on the organs of vision and the positive role of the consumption of antioxidants that promote eye health have been proven.

The known properties of blueberries to strengthen vision, which has long been used by traditional medicine (Kyosev P.A. A complete reference of medicinal plants. M: Esmo-Press, 2000/1 /). Blueberries contain anthocyanins, flavonoids, sugars, carotene, vitamin C, vitamin B, iron, copper, manganese, zinc, pectin, organic acids, tannins, glycoside mertilin / 1 /.

The use of fresh blueberries stimulates the metabolism, provides analgesic, capillary-strengthening, anti-inflammatory effect, accelerates the renewal of the retina of the eye membrane. Their use increases visual acuity, relieves eye fatigue as a result of prolonged work under artificial lighting, and exacerbates night vision.

Blueberries are the number 1 antioxidant in Europe: they are used by more than 20 million people (Biologically active food supplements. NutriPower company directory, M., ALFA-MED, 1996/2 /). It is indicated that blueberry extract has qualities that stimulate blood circulation, especially in the organs of vision. During the Second World War, English pilots noticed that during night flights their eyesight improved if they had eaten blueberries before.

To date, over thirty years of research have confirmed that blueberry extract accelerates the adaptation of eyes to light and darkness. This is especially important with age, when the adaptive capacity of the eyes decreases. Since blueberries improve cell membrane flexibility, it also helps increase blood flow to the retina. As a result of this, the capillaries are easier to stretch, which allows the red blood cells that deliver nutrients and oxygen to the eyes to move faster through the bloodstream, thereby strengthening eye health / 2 /.

It has been established that the anti-inflammatory and capillary-strengthening effect, retinal renewal are predetermined by the anthocyanins contained in the fruits of blueberries. Flavonoids (rutin, quercetin) improve blood supply to the eyes and reduce the fragility of capillaries (Minaeva V.G. Medicinal plants of Siberia. Novosibirsk, Nauka, 1991/3 /).

However, one of the disadvantages of the therapeutic and prophylactic use of blueberries is the short shelf life of fresh berries. In addition, the use of fresh berries creates significant difficulties in terms of the possibility of producing therapeutic and prophylactic preparations for wide sale to the population through the pharmacy network. The disadvantage is that the berries contain a small amount of active substances that positively affect vision, which requires the consumption of a significant amount of berries (both fresh and dried), which can cause undesirable effects on the part of the gastrointestinal tract.

In this regard, manufacturers of pharmaceuticals pay attention to the creation of more convenient therapeutic and preventive effects on eyesight, in which blueberries are used either independently or as the main ingredient of a complex drug.

In particular, the drug "Mertilene Forte" (Italy) is a hydroalcoholic dry blueberry extract in a solution of anthocyanidin (instructions for use). The capsules of the drug also contain soybean oil, gelatin, glycerin, red iron oxide, black iron oxide, sodium ethyl paraben, sodium propyl paraben. The drug is an encapsulated medicine, the indications for use of which are severe myopia, acquired hemeralopia, diabetic retinopathy, impaired adaptation of the eye in the dark, as well as night (scotoscopic) and twilight (mesoptic) vision, eye fatigue.

However, since this drug is a medicine, its use requires medical prescription and control, which reduces its sphere of consumption. The liquid consumer form (albeit encapsulated) creates in some cases problems during storage and transportation of the drug.

The domestic medicine using the properties of blueberries is Mirtikam (manufacturer - Kamelia firm of NPP), which is a homeopathic medicine in the form of tincture of blueberries with specially selected components that improve blood supply to the back of the brain (J. Health, 2000, No. 5 ) The drug is recommended for reducing visual acuity, as a means of protecting the eyes from fatigue during prolonged use. It is necessary for those who sit for a long time behind the wheel, books or a computer screen. It is also recommended for severe cervical osteochondrosis, dizziness, flickering "flies" in front of the eyes.

However, like the previous drug, Mirtikam is a medicine requiring medical prescription, which narrows the scope of its use. The liquid consumer form is also in some cases not convenient to handle.

Recently, considerable attention has been paid to the creation of non-medicinal means of therapeutic and prophylactic effect on the organs of vision - biologically active food additives (BAA) based directly on blueberries or when using it as one of the ingredients of BAA.

In particular, the Bilberry dietary supplement of the company Emrion (USA) / 2 / is known, which is pure natural blueberries placed in capsules, 25% of blueberries are contained in the capsule, the remaining ingredients are unknown. BAA supports the organs of vision, prevents the harmful effects of free radicals on the eyes, improves the adaptation of vision in the dark, strengthens the capillaries of the eyes.

The encapsulated dietary supplement Vital Vision / 2 / is also known, the multicomponent of which enhances the action of blueberries (content 36%) due to the presence of an additional 13 components, which, according to the manufacturers, makes it unique: vitamin E, vitamin B6, vitamin A (beta-carotene ), glutatin, taurine, chromium, L-glycine, L-cystine, zinc, vitamin A (palmitate), quercetin. Supplements are designed to improve vision, prevent the harmful effects of free radicals on the eyes, to improve adaptation of vision in the dark. This dietary supplement is the closest analogue in relation to the proposed technical solution.

However, the introduction into the body of additives and products obtained synthetically and artificially, but not contained in the natural organic complex, leads to slagging of the body, since it does not completely process them.

The objective of the present invention is to expand the range of products for the prevention of disorders and correction of vision, providing increased effectiveness with almost no side effects. The drug should have a convenient consumer form, allowing its administration in any environmental conditions.

The result achieved when using the invention is to create a herbal product that meets the status of dietary supplement, which does not require medical prescription and which allows you to get the most mild preventive effect on the body as a whole and on its individual organs and systems. The drug has a capillary and anti-inflammatory effect on the organs of vision, improves vision, prevents harmful effects of free radicals on the organs of vision, improves adaptation of vision in the dark and farsightedness in patients suffering from senile macular degeneration. In addition, when taking the drug, a number of additional positive effects on various organs and functions of the body are achieved, which helps to improve overall well-being.

The essence of the invention lies in the fact that a biologically active food supplement for the prevention of visual impairment and correction, including blueberries, additionally contains dry ginkgo biloba extract, fine powder of dry leaves of ginkgo biloba, magnesium and / or calcium stearate, starch and / or microcrystalline cellulose in the following ratio of ingredients, wt.%: powder of dried blueberries - 15.0-35.0; dry ginkgo biloba extract - 10.0-30.0; powder of dry leaves of ginkgo biloba - 10.0-40.0; magnesium and / or calcium stearate - 0.3-1.0; starch and / or microcrystalline cellulose - the rest is up to 100%. The additive is made in tablet or capsule form from powders of ingredients, crushed to particle sizes less than 500 microns.

The choice of ingredients and their quantitative ratio in the proposed dietary supplement is due to the following considerations.

One of the components is the dried blueberry fruit, which is contained in the dietary supplement in the form of a powder, the particle size of which does not exceed 500 microns. The powder of dried blueberries is contained in the proposed dietary supplement in an amount of 15.0-35.0 wt.%. The effect of blueberries on vision is described above.

Another important component of the proposed dietary supplement is the ginkgo biloba plant, which grows in China and Japan and is now cultivated all over the world (including in Russia). As medicinal raw materials, plant leaves containing ginkgoflavone glycosides and terpene-diterpene ginkgolides and bilobolides, organic acids, gingetin, isogingetin, etc. (Ginkgo Biloba. Natural Supplements to Cambridge Nutrition. Vita Intern. Inc., 1996/4 /) are used.

Usually, a concentrated extract of ginkgo biloba is used for medicinal purposes, which has a complex composition, including more than 40 ingredients, the main of which are flavonoid glycosides (quercetin and campferol - up to 24%), terpene compounds (ginkgolides and bilobolides - 6%) (Bulaev V. M. Clinical Pharmacology of Ginkgo Biloba Leaf Extract, State Scientific Center for Narcology of the Ministry of Health of the Russian Federation, Medicial and Pharmaceutical Bulletin. 1996, No. 7/5 /). However, in medical practice, natural leaves of the plant are used.

Due to the content of flavonoids, the extract and leaves of ginkgo biloba exhibit membrane-stabilizing properties, help maintain strength and elasticity of blood vessels, improve blood circulation, supply the brain with blood and oxygen, have an inhibitory effect on platelet aggregation / 5 /. In addition, clinical studies have proved the positive effect of ginkgo biloba leaves and their extract on microcirculation in the retina in people suffering from cerebrovascular accident / 4 /.

Due to the fact that flavonoids obtained from ginkgo biloba, including quercetin, are extremely powerful antioxidants, the extract and leaves of the plant reliably prevent the occurrence and severity of visual impairment and significantly improve farsightedness in patients with senile macular degeneration, which is clinically proven / 4, 5 /.

Due to the fact that the therapeutic effect of the extract and leaves of Ginkgo biloba is associated with flavonoids in their composition, and blueberries are associated with the content of anthocyanins and also flavonoids, these classes of compounds provide a unidirectional (possibly synergistic) effect on the organs of vision. In addition, this combination of phytocomponents in the proposed dietary supplement provides an additional positive effect of the drug on the functions of the brain, endocrine, cardiovascular and nervous systems, on which the most important functions of the body depend.

In the proposed dietary supplement, the manufacturing process of which meets the requirements of the developed project TU 9197-111-21428156-01, the amount of ginkgo biloba extract is 10.0-30.0 wt.%.

According to the invention, a fine powder of dry leaves of ginkgo biloba is also introduced into the dietary supplement in an amount of 10.0-40.0 wt.%. This technique allows, firstly, to use it as a physiologically acceptable excipient, providing tablets of the proper quality. Secondly, this allows you to increase the therapeutic and preventive effectiveness of the drug, since the filler in the form of a dry vegetable powder contains healing substances. Thirdly, the powder of leaves of ginkgo biloba compensates for the loss of some other valuable substances that occur in the process of obtaining a concentrated extract of ginkgo biloba.

Based on experimental studies of the tabletting process of the proposed drug, it was found that to ensure high quality products, the particle size of the powder of dry leaves of ginkgo biloba introduced into the drug should be less than 500 microns.

In a small amount (0.3% -1.0 wt.%) Magnesium and / or calcium stearate is introduced into the dietary supplement, which ensures a decrease in the hygroscopicity of the obtained tablets.

In order to improve the quality of the tablets in them (to obtain 100 wt.%), Starch and / or microcrystalline cellulose, usually used for such purposes in pharmaceutical production, is added.

EXAMPLE 1. A mixture is prepared at the rate of: 15.0 wt.% (30 mg) of dried blueberry powder, 10.0 wt.% (20 mg) of dry ginkgo biloba extract, 40 are taken per tablet of the proposed dietary supplement weighing 0.2 g , 0 wt.% (80 mg) of fine powder of dry leaves of ginkgo biloba, 0.3% wt.% (0.6 mg) of magnesium and / or calcium stearate, starch and / or microcrystalline cellulose in an amount providing 100 wt.% (34.7 wt.% Or 69.4 mg). The mixture is thoroughly mixed and passed through a sieve with a mesh size of less than 500 microns, after which the tablets are compressed or the capsule is encapsulated.

EXAMPLE 2. The mixture is prepared at the rate of: for one tablet of dietary supplement weighing 0.2 g, 35.0% (70 mg) of dried blueberry powder, 30.0 wt.% (60 mg) of dry ginkgo biloba extract, 10.0 wt. .% (20 mg) of fine powder of dry leaves of ginkgo biloba, 1.0 wt.% (2 mg) of magnesium and / or calcium stearate, starch and / or microcrystalline cellulose - the rest (24.0 wt.% Or 48 mg), after which the mixture is sieved and pressed in the form of tablets or placed in capsules.

Currently, normative documentation is being prepared for conducting official clinical and hygienic tests of the developed dietary supplement in the relevant instances of the Ministry of Health of the Russian Federation.

Claims (2)

1. Biologically active food supplement for the prevention of visual impairment and correction, including blueberries, characterized in that it additionally contains dry ginkgo biloba extract, fine powder of dry leaves of ginkgo biloba, magnesium and / or calcium stearate, starch and / or microcrystalline cellulose in the following ratio of ingredients, wt.%: dried blueberry powder 15.0-35.0 Ginkgo biloba dry extract 10.0-30.0 Ginkgo biloba dry leaf powder 10.0-40.0 Magnesium and / or Calcium Stearate 0.3-1.0 Starch and / or microcrystalline cellulose Rest   up to 100% 2. The additive according to claim 1, characterized in that it is made in tablet or capsule form from powders of ingredients, crushed to particle sizes less than 500 microns.