RU2178660C2 - "milona" curative-sanitation food biologically active additive and method for its obtaining - Google Patents

Abstract

FIELD: food industry. SUBSTANCE: the suggested additive includes the main plants' complex which contains roots and rhizomes of a licorice, a sweet flag and an elecampane taken at 2: 1: 1 ratio that have got a total physiological impact upon a body and, also, additional complexes of medicinal plants taken at a certain quantitative ratio to enhance separate effects and body reactions: enhanced action on respiratory system, improved activity of cardiovascular system, better sedative action, removed nervous stimulation, irritation, insomnia, climacteric disorders, decreased arterial pressure, regulated and normalized activity of gastrointestinal system, improved hepatoprotective action, normalized activity of a liver and a gall bladder, improved antisclerotic, cardiotonic, vasodilator action, stimulated brain work, improved memory, simplified attention concentration, improved work of both female and male sexual spheres, improved preventive and strengthening action. The method to obtain such an additive deals with reduction of plant raw material to a powder-like state at particles' size being less than 500 mcm, addition of supplementary components, formation of tablets or capsules and impact of sterilizing factor as an X-ray radiation of a certain energy and dosage. EFFECT: improved curative-sanitation complex of multiple impact upon a body as a whole and its separate functions and systems. 14 cl, 11 ex у _

Description

 The invention relates to the food industry, in particular to the production of biologically active food additives having a therapeutic effect on the human body.

 The current unfavorable environmental situation in the country, as well as alarming data on the decrease in the body's resistance to environmental factors, prompts to search for ways to strengthen the protective potential of the human body.

 A promising area is the development and development of a wide production of biologically active additives - concentrates of natural or biologically active substances identical to natural ones, intended for direct intake and / or incorporation into food products. Their ingestion allows you to quickly fill the deficit in the substances necessary for the body - vitamins, mineral salts, macro- and micro-elements (calcium, iodine, fluorine, iron, selenium, etc.), individual amino acids, dietary fiber and other compounds within their physiological norm. The consumption of such supplements, called nutraceuticals, is a form of prevention and adjunctive treatment for such widespread diseases as obesity, atherosclerosis and other cardiovascular diseases, malignant neoplasms, and immunodeficiency states.

 There are other additives - parapharmaceuticals, which include substances of natural origin, which have a stronger regulatory and stimulating effect on certain functions of the body: digestive, excretory, secretory, etc., as well as adaptogens. These include drugs that help reduce the energy value of the diet; appetite-regulating drugs; drugs that alter the intestinal microflora; regenerative stimulants; activators of secretory functions, cardiovascular and nervous systems; immunocorrections, etc.

 It should be emphasized that dietary supplements are not pharmaceuticals and belong to the group of OTC food and prophylactic agents, however, the border between them and medicines has not been clearly defined to date and is the subject of discussion by specialists. At present, it is accepted by official bodies that biologically active additives should have 4-10 times less active ingredient of the drug compared to its therapeutic dose (depending on the biological activity of the constituent substances).

 Characteristic features of the additives are the gentle action on the body, the absence of adverse reactions and intolerance, the possibility of providing a comprehensive effect, which is especially important in the presence of several diseases at the same time. They implement the mechanism of a non-pharmacological, safe way of regulating and supporting the functions of individual organs and systems of the human body, which ensures an increase in the level of health and a decrease in the incidence of disease.

 This approach is especially relevant in connection with a certain disappointment of the medical community in powerful synthetic drugs, often giving side effects, allergic reactions, drug diseases, from which many people die every year. Doctors recognized the fact that drug support does not solve the problem if the body’s defenses are not enough to restore its normal functions, or drug therapy itself weakens the protective functions (for example, when using potent drugs, radiation, surgical treatment methods).

 The creation of biologically active additives based on natural raw materials, characterized by low toxicity and the possibility of prolonged use without the risk of side effects, often allows you to solve problems that are not resistant to modern pharmacotherapy. Their use makes it possible to provide an effective preventive and healing effect at the initial stage of treatment and at the stage of recovery, as well as in the complex treatment of sluggish chronic diseases between the courses of basic treatment.

 Currently, a number of foreign and domestic companies produce a number of biologically active additives with different focus on the body / 1, 2 /.

 The analogues of the present invention include collections of medicinal plants and phytocomplexes introduced into the Gosfarmakopeia or used in traditional medicine / 3 /. The use of fees, as shown by many years of experience in folk and scientific herbal medicine, is more effective than the use of one plant due to the effects of summation, synergy and the ability to compensate for the undesirable effects of one plant with the properties of another. Therefore, complex phytocompositions can include from 4 to 65 plants and other natural sources.

 However, it should be noted that phytotherapy fees relate to medicines and not to nutritional supplements. Moreover, they often include poisonous plants, which requires their medical prescription and control, strict adherence to dosage, and contraindications.

 It should also be noted that usually plant-based therapies are prepared in the form of decoctions and infusions, involving the extraction of the active substances with the help of a liquid at high temperature. On the one hand, such processing of plant materials has positive factors, since it is thermally sterilized, that is, harmful microflora is destroyed, which, when ingested, can lead to infectious diseases. On the other hand, the heat treatment of raw materials can lead to the destruction of individual medicinal substances contained in plants. In addition, the aqueous extract of the active substances robs the body of some useful ingredients contained in plants. In particular, inert polysaccharides, which are plant fiber, i.e., dietary fiber, which ensure normal gastrointestinal motility, do not enter the body. Therefore, often to eliminate this deficiency and fill the deficiency of fiber, artificial addition of dietary fiber in the form of microcrystalline cellulose, bran, etc. to the therapeutic and prophylactic preparations is used.

 Another method of preparing medicines from medicinal plants is based on the preparation of alcohol tinctures or extracts. At the same time, without any heating, a sufficiently good sterility of the preparations is ensured, however, at the same time, some medicinal active substances may not be extracted from the plants and, as noted above, the remaining natural fiber is not used.

 The best way out of this situation is to eat natural foods such as herbs, vegetables, fruits, etc., which have healing properties. However, such an opportunity, as a rule, is absent in most of the year, which requires processing and harvesting plants for future use. Plants can be dried, crushed, and consumer forms prepared in the form of finely ground powders, tablets and capsules (with the addition of minerals if necessary). However, without additional measures to sterilize such dosage forms from natural raw materials, their ingestion is often unacceptable due to the possible microbial contamination of the feedstock.

 In addition, the consumption of only plant products may not fully satisfy the body's need for micro- and macro elements contained in sufficient quantities in a natural form in a number of minerals.

 Since this invention is not about drugs from natural raw materials, but about non-pharmacological agents in the form of biologically active food additives that have a healthy effect (mainly parapharmaceuticals), for example, the multicomponent vitamin mineral nutritional supplement urological action "Enhance" company "Enrich" (USA) / 4, p. 20 /, supplied to the domestic market.

 The additive "Enhance" is a powder containing minerals: iron, calcium, potassium, magnesium; herbs: chamomile, aralia, celery, alfalfa, dandelion, licorice, senega, passionflower, thyme, gentian, angelica, eleutherococcus, gotu kola, joster, mint, anise. The additive has the following effects: vitamin, anti-inflammatory, antibacterial, antiseptic, regulating the metabolism and hormonal balance of men, rejuvenating the female body, tonic, general strengthening, increasing defenses, regulating water-salt metabolism, antitoxic, improving microcirculation, improving general condition. Reception is carried out according to 1 tbsp. l 2 times a day with water.

 Information about the specified preparation does not contain information about the technological features of the preparation of its ingredients, issues of ensuring the microbiological purity of plant ingredients, etc. However, its obvious disadvantages are the powder form, which complicates dosing and does not provide ease of use in any environmental conditions. The composition includes ingredients that are not characteristic of the conditions of our country, which, according to scientific research, reduces its usefulness for use by the population of regions where such plants do not grow. The creation of domestic additives containing plants not included in the State Pharmacopoeia is complicated by the need for lengthy and costly tests, the complexity of the design of the necessary regulatory documents, etc.

 The objective of the present invention is the development of such a health-improving biologically active food supplement, which would include a set of domestic most effective and authorized official bodies of plants. Such an additive should provide, in addition to a wide range of actions on the body of a general strengthening character, a targeted specific effect on certain functions and reactions of the body in accordance with the status of the latter or the environmental conditions of his residence in the area. The additive should have technological features of production, providing the possibility of its wide release in a form convenient for consumption, storage and reception with maximum preservation of active substances present in plants that are useful for the body. Moreover, the technology must meet all standards for ensuring the microbiological purity of the drug, regardless of the initial parameters of the raw material.

 The result achieved by using the invention is to develop a therapeutic and health-improving biologically active additive "MILONA" and a method for its production that satisfy the above requirements.

 The applicants of the present invention called the proposed additive "MILON", putting in it the following meaning. The designation comes from the Greek word "mylon" - mill, and the English word "mill" - mill, grind, crush, grind, and reflects the main feature of the technology used: the manufacture of the additive ingredients in the form of fine powder, followed by giving the additive a consumer form in the form of tablets or capsules.

 The essence of the invention lies in the fact that the proposed therapeutic and biologically active food supplement containing a multicomponent mixture of medicinal plants contains the main complex, consisting of plants that have a multilateral physiological effect on the body, and an additional complex of plants, designed to enhance individual effects and reactions organism, while the main complex includes the roots and rhizomes of licorice, calamus marsh and elecampane, taken in a ratio of 2: 1: 1. Additional to Plex, designed to enhance the effect on the respiratory system, includes the leaves of the large plantain, oregano grass, thyme grass, St. John's wort, yarrow grass, flax seeds, chamomile flowers taken in a ratio of 2: 4: 2: 2: 2: 2: 2. An additional complex designed to improve the activity of the cardiovascular system, provide sedation, relieve nervous excitement, irritability, insomnia, menopause, lower blood pressure, includes motherwort grass, flowers or fruits of a boyar eggs, valerian roots, dill fruits, calendula flowers, evading peony roots, oregano grass, chamomile flowers taken in the ratio 1: 3: 1: 1: 1: 2: 2: 1. An additional complex designed to regulate and normalize the activity of the gastrointestinal tract - intestinal system, includes burdock roots, caraway or anise fruits, lemon balm or peppermint grass, senna leaves or flax seeds, hypericum, valerian roots, yarrow, taken in a ratio of 2: 2: 2: 1: 2: 1: 1 An additional complex designed to provide hepatoprotective action, n the normalization of the activity of the liver and gall bladder, includes sandy immortelle flowers, nettle leaves, dandelion roots, yarrow grass, chamomile flowers, St. John's wort grass, calendula flowers, dill fruits taken in a ratio of 3: 2: 2: 1: 1: 1: 2: 2. An additional complex designed to regulate and normalize the functioning of the urinary tract includes bearberry leaves, bird of highlander, dill, horsetail, flax seeds, plantain leaves, and juniper fruits taken in a ratio of 3: 3: 2: 2: 1: 1: 3. Additional complex, predn significant for providing antisclerotic, cardiotonic, vasodilating effects, includes flowers or fruits of hawthorn, bearberry leaves, marigold flowers, plantain leaves, motherwort grass, dill, horsetail grass, St. John's wort, yarrow grass, yarrow thallus, taken in a ratio of 3: 1: 2: 1: 1: 2: 2: 2: 2: 2. An additional complex designed to stimulate the work of the brain, improve memory, and facilitate concentration of attention, includes frankincense leaves, rhizomes and roots of the leuzea, rhizomes and roots of Rhodiola rosea th, as well as L-glutamic acid, taken in a ratio of 1: 2: 1: 4. An additional complex designed to improve the female genital area includes the roots and rhizomes of badan, yarrow grass, mountaineer, birdwort taken in a ratio of 1 : 2: 3: 3. An additional complex designed to improve the male genital area includes the rhizomes of Rhodiola rosea or safflower levzea, the roots and rhizomes of the evading peony, St. John's wort, sage grass, anise fruits, nettle leaves taken in a 1: 1 ratio: 1: 2: 2: 3. To An additional complex designed to provide a preventive and general strengthening effect includes rose hips, nettle leaves, hawthorn fruits, common mountain ash fruits, aronia fruits taken in a ratio of 5: 2: 3: 1: 2, as well as ascorbic acid, β-carotene , α-tocopherol, the average values of which are taken in the ratio of 0.16: 0.01: 0.13. Aerosil and / or talc, glucose and / or starch, and / or microcrystalline cellulose, taken in a ratio of 10: 0.5: 2.5, are added to the additive as auxiliary substances. To enhance the action of medicinal plants and replenish the body with macro- and microelements, the main and additional complexes of medicinal plants can be supplemented with an organo-mineral substrate, in particular, a mummy extract in a ratio of 10: (0.5 - 1.0). A method of obtaining a health-improving biologically active food supplement involves grinding the raw material to a powder state with particle sizes less than 500 microns, adding auxiliary components, forming tablets or capsules and exposing them to a sterilizing factor in the form of X-ray radiation with an energy of 0.3-1.0 MeV and an absorbed dose of 0.7-10.0 kGy, or when forming tablets, ingredients that are previously sterilized by the indicated physical factor are used.

 The choice of plants in the main complex is due to the following considerations. It includes several plants authorized by the State Pharmacopoeia, which have the maximum multilateral physiological effect on the body, verified by many years of experience in scientific and traditional medicine and having wide raw materials in our country.

 Licorice (licorice root) - Siberian scientists involved in Tibetan medicine found that licorice among the many medicinal plants ranks first in its medicinal properties and is included in 98% of all fees / 5 /. In eastern medicine, it is treated almost the same as ginseng / 6 /. It should be borne in mind that Russia was once the main supplier of licorice to the world market.

 Licorice preparations have anti-inflammatory, diuretic, laxative, anti-acid, antihistamine, expectorant, diaphoretic, analgesic, antispasmodic, anti-allergic, general strengthening, antimicrobial, detoxifying toxins, relaxing smooth muscle properties. It has hormonal activity. Currently, there is evidence of anticancer activity of licorice.

 It is proposed to use licorice for the treatment of prostatitis, urethritis, prostate adenoma and other diseases of the genitourinary sphere (RF patents 2058152, 2088252, 2098119), adnexitis (RF patent 2045955). Licorice is used in pulmonary collections (RF patents 2013094, 2072862, 2103002), collection for the treatment of gastritis with high acidity, gastric ulcer and 12 duodenal ulcer (RF patent 2000806), gastrointestinal (RF patent 2103001), for detoxification of the body ( RF patent 2032420), to relieve cravings for alcohol (RF patent 2097053), antidiabetic collection (RF patent 1697820), antisclerotic (RF patent 2020952), hepatoprotective (RF patent 2087154), as a stimulator of immunological resistance to bacterial and viral infections ( RF patent 2000799), ingredient that means for restoration and biostimulation of the endocrine and immune systems, sex glands, normalization of the gastrointestinal tract, increase the body's resistance to complex nonspecific damaging factors, including radiation (RF patents 1826910, 1836094, 2034558), immunomodulator in the treatment of autoimmune and lymphoproliferative diseases (RF patent 2003340), adverse environmental factors (RF patent 2029557), adaptogenic action balms (RF patents 2008914, 2063764), anaphylactic drugs I (RF patent 2027438), for the treatment of psoriasis (RF patent 2082426), for rehabilitation after acute respiratory infections (RF patent 2020950), for cleansing the body (RF patent 2097052), in an agent for the prevention and treatment of malignant neoplasms (RF patent 2044547).

 In official medicine, drugs from licorice root “Liquiriton”, “Glycyram”, “Gliderinin”, “Likurazid”, “Flacarbin”, used as pharmacopeia for the treatment of gastric ulcer and duodenal ulcer, various kinds of inflammations, have spread. The ability of "Glyciram" to serve as a hemostatic stimulator for the restoration of hematopoiesis during cytostatic hemodepression was discovered (RF patent 2088249). It is known the use of licorice in pharmacopoeial collections: breast, laxative, antihemorrhoidal / 7 / and others / 3 /.

 According to Chinese scientists, licorice root rejuvenates the body (Mustong phytodrugs from Orient Pharma Priveit, Enhance from Enrich, USA), is used for weight loss (Nova Figurat phytodrugs from Naturvaren company, Germany), treatment digestive organs (herbal preparations "Tiem Long", "Thang Long" company "Bao Long", Vietnam).

 Since the time of Avicenna, the ability of licorice to increase potency has been known, which, apparently, was reflected in the Super Yohimbe-plus nutraceuticals of Irvin Nachurals (USA), Licorais and Enhance of Enrich (USA). These supplements are used to prevent the occurrence of prostate adenoma and inflammatory diseases of the female genital area. Likorays and Herbal Iz support the natural defense mechanisms of the gastrointestinal tract. Licorice root is used in Bres of Life dietary supplements from Emrion (USA) to support the full functions of the respiratory system, Bupleurum as an anti-inflammatory and contributing to the normal functioning of the liver. It is included in various tonic drinks, in particular in Pepsi-Cola and Coca-Cola / 6 /. Enrich's Per Forma additive regulates the work of all organs of the female body, promotes its rejuvenation, and is a prevention of cancer. The drugs "Red Clover Plus", "Hyp" of the same company have antibacterial, antitoxic, vitamin and other effects on the female body.

 Air marsh - a plant widely distributed in Russia and known for its healing properties, is considered from ancient times and until now a universal home remedy. It has analgesic, anti-inflammatory, antipyretic, diuretic and disinfectant effects, slightly reduces blood pressure, improves eyesight. It is used as bitterness to stimulate appetite, with heartburn, with inflammation and peptic ulcer of the stomach and duodenum, diarrhea of various origins and other digestive disorders. It is also used for diseases of the liver and biliary tract, urolithiasis, as well as an anti-stress agent that tones the nervous system. The powder from calamus rhizomes is part of the pharmacopoeial anti-ulcer drugs "Vicalina" and "Vikaira", in collections that improve digestion. Chewing the root helps with toothache and inflammation of the oral mucosa (periodontal disease, glossitis, gingivitis, etc.).

 It is used as an ingredient in the treatment and prevention of periodontal diseases (RF patent 2060033), in the treatment of atopic dermatitis in children (RF patent 1793927), in the gastrointestinal collection (RF patent 2103001), for exposure to the liver and gall bladder with hypothalamic syndrome in women (RF patent 2101024), for cleansing the body (RF patent 2097052), for the treatment of acute respiratory infections (RF patent 2068701), for the prevention and postoperative treatment of malignant neoplasms (RF patents 2027441, 2044547), in a phytocomplex with antitumor activity (patentF 2074731), and others. / 3 /.

 It is used in cardiovascular diseases as antiarrhythmic, in sexual disorders in men and women, in case of neurasthenia, in the pathological course of menopause, in diseases of the thyroid gland, as a tonic, restorative, anti-febrile and expectorant drug for acute respiratory viral infections. It has an anti-nicotine effect, which has found its application in the Corrida + dietary supplement created by the authors of the present invention (RF patent 21345 85). In folk medicine, calamus roots are used for the prevention and treatment of benign and malignant neoplasms / 6 /.

 Air is an ingredient in the "Bittner Balsam" firm "Richard Bittner" (Austria) universal therapeutic purpose; the preparation "Swedish bitterness" of the company "Naturvaren" (Germany); phytochemicals "Olimetin", Nizhpharm (RF) used for the treatment and prevention of cholelithiasis and urolithiasis.

 Elecampane is widely used in scientific and folk medicine, it has anti-inflammatory, hemostatic, choleretic, expectorant and diuretic effects, regulates the activity of the gastrointestinal tract, slows intestinal motility and secretory activity, while enhancing the excretion of bile into the duodenum. It also has antimicrobial and anthelmintic properties, and is especially effective for ascariasis. It is used for catarrh and pulmonary tuberculosis, for diseases of the stomach, for atherosclerosis. Useful elecampane and as an activator of muscle and mental activity, with fatigue, fatigue / 6 /. Isolated from the rhizomes and roots of elecampane galenic preparation "Allanton" / 5, 7 / has anti-ulcer, choleretic, anti-inflammatory, capillary-strengthening, antimicrobial and anti-radiation activity. Rhizomes and roots are included in various collections of antihepatotoxic, antidiabetic, antiulcer and other actions / 3 /.

 It is the source for the Inulin pharmacopoeial preparation used against diabetes (RF patent 1214104), used in collections: antidiabetic (RF patent 1697820), hepatoprotective (RF patent 2087154), breast (RF patent 21087154), for the treatment of adnexitis (RF patent 2045955), for the treatment of acute respiratory infections (RF patent 2068701), for the prevention and postoperative treatment of malignant neoplasms (RF patent 2027441), etc. / 3 /. Based on elecampane, an agent with antitumor activity was developed (RF patent 2056856). It is widely used in folk medicine, in connection with which it was given the name (nine powers): for cystitis, malaria, bone tuberculosis, rheumatism, jaundice, dropsy, hemorrhoids, as a stimulating and wound healing agent, for gastroenterocolitis, bronchitis, liver and kidney diseases as an antidote for poisoning. It is believed that his intake improves mood, strengthens the heart, sexual potency.

 Elecampane is an ingredient in a number of foreign drugs: "Bittner Balsam" firm "Richard Bittner" (Austria) universal therapeutic purpose; herbal tea "Depuraflux" company "Ron-Pulenck Rohrer" (USA-France) against constipation and hemorrhoids; herbal tea "Uroflux" of the same company - with pyelitis, cystitis, urethritis; phytopreparation "Tonsilgon N" of the company "Bionorika" (Germany) - prevention and additions to the treatment of acute and chronic bronchopulmonary diseases, viral and bacterial infections, including in early childhood.

 Plants included in the main complex of biologically active additives "MILON" according to the invention are taken in a ratio of 2: 1: 1, selected experimentally.

 As can be seen from the consideration of the characteristics of plants included in the selected main complex, it is able to provide a multilateral health impact on the body as a whole and a number of its individual functions.

 At the same time, it is known that the individual characteristics of the body, regional aspects of nutrition, environmental features of living in a certain area, and a number of other factors can lead to the predisposition of the body to pathologies quite limited in localization, or to the breakdown of individual systems bordering on the onset of pre-disease states. The use of drug intervention in such cases can lead to an excessive load of organs and systems that are not associated with this pathology, and the appearance of various kinds of side effects and complications. The same can be observed in conditions of reduced immunological resistance of the body after suffering serious illnesses.

 In these cases, it is advisable to use the drug "MILONA", containing in addition to the main complex additional complexes of medicinal plants.

 In particular, according to the invention, to enhance the effect on the functions of the respiratory system, it is advisable to use an additional complex, including large plantain, oregano, thyme, St. John's wort, yarrow, flax seeds, chamomile, taken in a ratio of 2: 4: 2: 2: 2: 2: 2.

 Large plantain (leaves) has a wide spectrum of action. It has long been used as an anti-inflammatory, antitoxic, antiallergic, regenerative, antimicrobial, diuretic, choleretic, painkiller, hemostatic agent for gastrointestinal diseases: catarrh, gastritis, enteritis, enterocolitis, for kidney and liver diseases, for ulcers of the stomach, and for ulcers of the stomach hemorrhoids, with chronic nephritis, atherosclerosis, diabetes mellitus, with male and female impotence, and even with stomach cancer. Stimulates hematopoiesis, is useful in the treatment of atherosclerosis, hypertension. The pharmacopeia drug Plantaglucid, which is a dry extract from plantain leaves, has received the greatest use as an antiulcer and antispasmodic in gastritis with normal or low acidity, gastric ulcer and 12 duodenal ulcer. Plantastin, obtained from plantain, has an antisclerotic effect. However, anti-inflammatory and expectorant properties have created the greatest glory for plantain for respiratory diseases: for cough, bronchitis, catarrh, pertussis, and even asthma and tuberculosis.

 It is used in pulmonary collections (RF patents 2013094, 2072862), for the rehabilitation of the body after acute respiratory infections (RF patent 2020950), in the vessel (RF patent 2076729), a fee for the treatment of dysbiosis caused by antibiotic therapy (RF patent 2040934), for the treatment of gastrointestinal diseases ( RF patent 2077332), in the tool for the prevention and treatment of periodontal disease (RF patent 2060033), for the prevention and treatment of disorders of the genitourinary system (RF patent 2098117), diabetes mellitus (RF patent 2000802), for detoxification of the body (RF patent 2032420), for prevention and postoperative treatment of zl high-quality neoplasms (RF patent 2027441), in a phytocomplex with antitumor activity (RF patent 2074731), etc. / 3 /.

 It is used as an ingredient in Keateaker and Fibergen bioadditives from Emrion company (USA) as a source of dietary fiber for cleaning and detoxifying the colon and ensuring regular stool.

 Oregano has anti-inflammatory, diuretic and choleretic properties, has a detrimental effect on the microbial flora. It is used to increase appetite, improve digestion, with liver diseases, hypertension, insomnia, increased nervous irritability, menopause, etc. The most famous are the expectorant and soothing properties of oregano, which is why it is recommended for bronchitis, bronchopneumonia, bronchiectasis, and pulmonary tuberculosis. It is recommended for increased sexual excitability, however, it does not affect healthy people in this regard / 6 /.

 Included in the fees: cardiological (RF patent 2072863), antihypertensive (RF patent 2092176), cardiovascular effect (RF patents 2000807, 2076729), antisclerotic (RF patent 2020952), against insomnia (RF patent 2012347), against bronchopulmonary diseases ( RF patent 2013094, 2103002), diabetes mellitus (RF patent 2000802), in a balsamic agent for general use (RF patent 2063764), for the treatment of hypothalamic syndrome in women (RF patent 2101024), Pantogram general strengthening additive (RF patent 2100938) and other / 3 /.

 Thyme (creeping thyme) has a wide therapeutic spectrum. It has expectorant, enveloping, disinfectant, anti-inflammatory, sedative, antihypertensive, anticonvulsant, antiseptic, analgesic, antiseptic, hemostatic properties. The anti-allergic effect of herbal remedies from thyme herb has been proved (RF patent 2036655). Used in the collection to relieve cravings for alcohol (RF patent 2097053), breast (RF patent 2103002) and other fees / 3 /. Also obtained is a phytochemical having anti-sclerotic, anti-mitogenic, cardiotonic, anti-allergic and immunomodulatory effects (RF patent 2036657). Used in a balsamic biologically active agent for a wide range of applications (RF patent 2063764). Immunomodulatory and anti-allergic properties increase and decrease the increased immunity in patients with chronic obstructive bronchitis, psoriasis, atonic dermatitis. It is recommended for various diseases of the digestive system, kidneys. The most widely used in catarrh of the upper respiratory tract, bronchitis, pneumonia. It is a very good remedy for treating cough in children. In imported preparations, it is mainly used in the form of thyme essential oil / 2 /.

 St. John's wort is a widely used means of folk and scientific medicine. It is used as an astringent, anti-inflammatory and antimicrobial agent. Able to regulate metabolism. In addition, it has wound healing, antispasmodic, diuretic, choleretic and anthelmintic properties. Strengthens the walls of capillaries, improves venous circulation and blood supply to some internal organs.

 It is used internally for inflammation of the liver, gall bladder, bladder, tendency to diarrhea, and inflammatory diseases of the gastrointestinal tract. It is also used for headaches and dizziness, for urinary incontinence, for cardiovascular diseases and rheumatism, for diseases of the female genital area, for inflammatory processes of various origins, gastric and duodenal ulcers, hemorrhoids, and liver tumors. Useful in the treatment of functional sexual failure. Abroad, as a remedy for impotence, it is valued higher than ginseng and the golden root.

 St. John's wort is widely used for catarrh of the respiratory tract, against profuse sputum, for coughing, bronchitis, tuberculosis, in anti-periodontal drugs (RF patent 2060033), as an ingredient in a collection that stimulates sexual hormonal functions (RF patent 2000803), to relieve alcohol cravings (patent RF 2097053), anti-diabetic fees (RF patents 1456156, 1697820, 2000802), for detoxification of the body (RF patent 2032420), for cleansing the body (RF patent 2097052), for the treatment of gastritis with high acidity, gastric ulcer and 12 duodenal ulcer ( patents P F 2000806, 2077332), chronic cholecystitis (RF patent 1821199), gallstone disease (RF patent 1685457), for the prevention and treatment of dysbiosis (RF patent 2000804), for the treatment of adnexitis (RF patent 2045955), hypertensive collection (RF patent 1790945), for the treatment of headache (RF patent 2020951), prostatitis and urethritis (RF patent 2098119), in a balsamic drug (RF patent 2063764), for the treatment of hypothalamic syndrome in women (RF patent 2101024), for the prevention and postoperative treatment of malignant neoplasms (RF patents 2027441, 2044547), serves as an ingredient in avg. a drug having anti-blast activity (RF patent 2008909), in a phytocomplex having antitumor activity (RF patent 2074731), etc. / 3 /.

 St. John's wort is used in the preparation "Debrifin" of the company "Bional" (Netherlands), which relieves internal stress, overwork, irritability, depression; in the calming collection "Quizda" company "Kwiza Farma" (Austria); in the collection "Novopassit" of the company "Galena" (Czech Republic), which relieves neurotic syndrome, insomnia, menopause, neurovegetative dystonia; "Turineurin" company "Yenapharm" (Germany), which is a dry extract of St. John's wort, also relieves psycho-vegetative disorders, depression, anxiety, insomnia, fear, nervousness.

 Yarrow has anti-inflammatory, bactericidal, anti-allergic, antispasmodic, antimicrobial, choleretic, wound healing, hemostatic effect, relaxes smooth muscles of the intestines, urinary tract, increases bile secretion, reduces blood pressure, stimulates milk production in lactating women. It is used for gastritis, peptic ulcer and duodenal ulcer, hemorrhoids, colitis and other diseases associated with digestive disorders, including those caused by dysbiosis as a result of antibiotic therapy (RF patent 2040934) and pains in the stomach and intestines, female diseases, in in particular adnexitis (RF patent 2045955), with insomnia, a base disease. The grass is part of antidiabetic (RF patent 1697820), hypertonic (RF patent 1790945), cardiological (RF patent 2072863), urological (RF patents 2098118, 2098116), pulmonary (RF patent 2072862), for cleansing the body (RF patent 2097052), to relieve cravings for alcohol (RF patent 2097053), hemostatic (RF patent 2000805), against cholecystitis (RF patent 2003342) and gallstone disease (RF patent 2045956), in a balsamic agent (RF patent 2063764), in the Rotokan preparation for treatment skin and dental diseases (RF patent 1561262), gastric, laxatives GOVERNMENTAL and appetizing fees means serves ingredient having antiblastic activity (RF Patent 2008909) in phytocomplex possessing antitumor activity (RF Patent No. 2074731), and others. / 3 /.

 The constant use of yarrow tea provides longevity / 8 /. It is a raw material for obtaining "Azulen" - an effective treatment for radiation injuries, tumors and as an antiseptic. Yarrow is used as a diaphoretic and firming agent for bronchopulmonary diseases, pulmonary tuberculosis.

 It is part of the phytopreparation "LIV-52" of the company "Himalaya" (India), which improves liver function; choleretic tea "Holaflux" company "Ron-Poolenc Rohrer" (USA-France); herbal medicine "Menodoron" of the company "Weleda" (Switzerland), which is the basic tool in the treatment of any violations of the female condition; phytopreparation "Tonsilgon N" of the company "Bionorika" (Germany) - for the prevention and addition to the treatment of acute and chronic bronchopulmonary diseases, viral and bacterial infections, including in early childhood.

 Flax (seeds) - flax mucus has an enveloping and anti-inflammatory effect. It is used for inflammatory diseases of the respiratory tract and gastrointestinal tract, atherosclerosis. It has a regulatory effect on the secretory and motor function of the intestine: with diarrhea it acts as a light fixing agent, with constipation, gastritis, gastric ulcer and 12 duodenal ulcer - as a mild laxative. Used as a diuretic, increases the amount of milk in nursing mothers. It is used in the treatment of kidneys and bladder, in the treatment of spleen tumors, in an antisclerotic collection (RF patent 2020952), in the collection for the prevention and treatment of toxicosis of pregnant women (RF patent 20001625), diabetes mellitus (RF patent 2000802), and chest (RF 2103002) et al. / 3 /.

 The drug "Linetol", prepared from flaxseed, is used in the treatment of atherosclerosis. Flaxid Oil (USA), a linseed oil bioadditive, is used to lower cholesterol and improve the functioning of the immune system.

 Chamomile (flowers) is widely used in folk and scientific medicine. It has a versatile effect on the body. It has anti-inflammatory, analgesic, sedative, emollient, anticonvulsant, diaphoretic, choleretic and anti-allergic effects, reduces fermentation, has a laxative effect, relieves intestinal cramps and swelling of the gastric mucosa, and promotes the rapid healing of stomach ulcers and 12 duodenal ulcers. It is used for inflammatory diseases of the gastrointestinal tract (gastritis, enteritis, colitis), flatulence, liver and kidney diseases. Normalizes menstruation and sexual potency.

 It is included as an ingredient in various fees: for the treatment and prevention of pyelonephritis and nephrolithiasis (RF patent 2082418), gallstone disease (RF patent 1685457), cholecystitis (RF patents 1821199, 2003342), for the treatment of gastritis with high acidity, gastric ulcer and 12 duodenal ulcer (RF patent 2000806) and other gastrointestinal diseases (RF patents 2077332, 2103001), for the prevention and treatment of dysbiosis (RF patent 2000804), for the regulation of metabolism (RF patent 2103004), for the treatment of adnexitis (RF patent 2045955 ), antidiabetic (RF patents 14 56156, 1697820), cardiological (RF patent 2072863), pulmonary (RF patents 2072862, 2103002), antisclerotic (RF patent 2020952), in the Rotokan preparation of anti-inflammatory and healing effect (RF patent 1561262), in a phytocomplex with antitumor effect ( RF patent 2074731) and others / 3 /.

 Included as an ingredient in the adopted as a prototype dietary supplement "Enhance" (USA); in the supplement "Emrion" (USA) "Stress Master" - to support the nervous system, relieve stress and fatigue; "Pisful Slumber" - to calm the nervous system, improve sleep; "Restful" - for use at night as a sedative; "Stress Di" - to restore the body during stressful situations; "Erender" - to relieve excitement and nervous tension.

 EXAMPLE 1. To obtain 10 kg of the intermediate product (powder from dry plants suitable for further tabletting) supplements designed to enhance the effect on the respiratory system, take 1.0 kg of licorice roots and rhizomes, 0.5 kg of marsh calf, 0.5 kg elecampane, 1.0 kg of plantain leaves, 2.0 kg of oregano and 1.0 kg of thyme, St. John's wort, yarrow, flax seed, chamomile flowers.

 According to the invention, in order to improve the activity of the cardiovascular system, provide sedation, relieve nervous excitement, irritability, insomnia, menopause, lower blood pressure, MILON, in addition to the main complex described above, includes an additional complex of medicinal plants, including motherwort herb , hawthorn flowers, oregano grass, valerian roots, dill fruits, chamomile flowers, evading peony roots, taken in a ratio of 1: 3: 1: 1: 1: 2: 2: 1.

 We give a brief description of the plants included in this complex.

 Motherwort has a sedative, antispasmodic, cardiotonic and hypotensive effect in cardiovascular neurosis, the early stages of hypertension, mild forms of angina pectoris, bazedovoy disease, heart muscle disease and heart defects.

 Often used in collections: general strengthening and antisclerotic action (RF patent 2020952), for the treatment of insomnia (RF patent 2012347), cardiovascular diseases (RF patents 2000807, 2072863), antispasmodic action (RF patent 1792707), treatment of cholecystitis and gallstone disease ( RF patents 2044546, 2045956), pyelonephritis (RF patent 2026079), diabetes mellitus (RF patent 2000802), hypertension (RF patent 1790945), pregnant women toxicosis (RF patent 2001625), for rehabilitation of the body after acute respiratory infections (RF patent 2020950), for body cleansing (RF patent 2097052), for regul metabolism yatsii (Russian patent 2103004) for the treatment of hypothalamic syndrome in women (RF Patent 2101024) serves ingredient means having antiblastic activity (RF Patent No. 2008909), and others. / 3 /.

 Motherwort is used as an ingredient in foreign preparations: Rov-Pulenk Rohrer Biovital (USA-France) - to increase vitality in diseases of the cardiovascular and central nervous system, during stress, physical overstrain, etc. "Gerovital" of the company "Naturvaren" (Germany) - for fatigue, poor sleep, functional diseases of the cardiovascular system, after suffering serious illnesses and during recovery.

 Hawthorn (flowers or fruits) - drugs have a multilateral effect on the body: lower blood pressure, normalize the rhythm of heart contractions, act antispasmodically on coronary and cerebral vessels, increase bile secretion, lower blood cholesterol, therefore they are used for angioeurosis, atrial fibrillation, tachycardia, hypertension, angina pectoris, atherosclerosis, insomnia, during menopause. Used in the form of infusions, tinctures, pharmacopeia drug "Cardiovalen". A tablet preparation from the fruits of hawthorn has been developed for the treatment of tachycardia and angioneurosis (RF patent 2085206). Included in many fees: general strengthening and anti-sclerotic effects (RF patent 2020952), antihypertensives and sedatives (RF patents 1837887, 2019185, 2092176), against insomnia (RF patent 2012347), to relieve alcohol cravings (RF patent 2097053), for cleansing organism (RF patent 2097052), with antispasmodic activity (RF patent 1792707), for the treatment and prevention of pyelonephritis and nephrolithiasis (RF patent 2082418), cholecystitis (RF patent 1821199), cardiovascular diseases (RF patents 2000807, 2088250, 2082420), against diabetes mellitus (RF patent 2000802), for treatment with hypothalates syndrome in women (RF patent 2101024), in the tool for the prevention and treatment of malignant neoplasms (RF patent 2044547), in the tool "Energoton", which has a tonic and restorative effect (RF patent 2018316), etc. / 3 /.

 Hawthorn is a component of many foreign herbal remedies: Biovital (USA-France), Gerovital (Germany), Novopassit (Czech Republic), etc. / 2 /.

 Valerian (roots and rhizomes) reduces the excitability of the central nervous system, relaxes smooth muscle spasms, helps to expand the blood vessels of the heart and lower blood pressure. It is widely used as a sedative for nervous agitation, insomnia, hysteria, convulsions, vegetative-vascular dystonia, as well as for spastic conditions of the stomach and intestines. It is used in the form of tinctures, decoctions, extracts (RF patent 2098115), for the preparation of preparations "Valocarmida", "Corvalol", drops of Zelenin, "Cardiovalena" and others, as well as an integral part of various collections, for example: general strengthening and anti-sclerotic action (RF patent 2020952), drugs for treating insomnia (RF patent 2012347), for the treatment of cardiovascular diseases (RF patents 2000807, 2088250), antispasmodics (RF patent 1792707), antihypertensive (RF patents 1790945, 1837887), for prevention and treatment of toxicosis of pregnant women nt RF 2001625), for the treatment of hypothalamic syndrome in women (RF patent 2101024), etc. / 3 /.

 Valerian forms a dietary supplement "Valerian" of the company "Emrion" (USA) to provide many-sided effects on the body: calming the nervous system, relieving nervous excitement / 1 /, insomnia, epilepsy, hysteria, regulates the activity of the heart, etc. the drug from valerian "Circuline" company "Roja" (Germany) has the same effect; included as an ingredient in the dietary supplements "Pisful Slumber" and "Erender" of the same company to calm the nervous system, relieve nervous tension and excitement, improve sleep; is included in the herbal remedies of the calming action "Quizda" (Austria), "Nervoflux" (USA-France), etc. / 2 /.

 Dill (fruits) has vasodilating, anti-inflammatory and antiseptic properties, stimulates the separation of gastric juice, is used as a diuretic for pyelonephritis and urolithiasis, to improve appetite, as a sedative for insomnia, convulsions and colic, to stimulate the separation of milk in lactating women, like diaphoretic , anti-inflammatory and expectorant for colds and diseases of the upper respiratory tract, as a carminative, for diseases of the liver and biliary their paths as a mild laxative.

 It is used in the collection for the treatment of gallstone disease (RF patent 1685457), the collection of general strengthening and antisclerotic effects (RF patent 2020952), the gastrointestinal (RF patent 2103001), for detoxification of the body (RF patent 2032420), the treatment of dysbiosis (RF patent 2000804), urinary system (RF patents 2001624, 2103003) and others / 3 /.

 Used by the authors of the present invention as an ingredient of the dietary supplement "Fitolax", regulating the intestines (RF patent 2134044).

 Calendula (marigolds) has a wide range of pharmacological activity, has an antiseptic, anti-inflammatory, wound healing effect both for internal and external use. It is also used as an antispasmodic, painkiller, choleretic, antipruritic, sedative, blood purifying, lowering blood pressure and headache. Promotes normalization of cardiac activity, reduces swelling. It is used for hypertension, especially during menopause, for heart diseases accompanied by heart palpitations and other rhythm disturbances, liver and gall bladder diseases, gastric ulcer and 12 duodenal ulcer, gastritis, enteritis, colitis, as a symptomatic remedy for tumor diseases.

 Included as an ingredient in many drug collections: antihypertensive (RF patents 1837887, 2092176), for the treatment of chronic cholecystitis (RF patents 1821199, 2087154), chronic pyelonephritis (RF patents 2026079, 2082418), urinary system (RF patents 2001624, 2103003), adn (RF patent 2045955), thoracic (RF patent 2103002), inflammatory diseases (RF patent 1836098), hemostatic effect (RF patent 2000805), for the treatment of cardiovascular diseases (RF patent 2000807), diabetes mellitus (RF patent 1697820) , general strengthening and anti-sclerotic action (p RF patent 2020952), for detoxification (RF patent 2032420), body cleansing (RF patent 2097052), treatment of hypothalamic syndrome in women (RF patent 2101024), in a balsamic agent for general use (RF patent 2063764), in a means for prevention and postoperative treatment malignant neoplasms (RF patents 2027441, 2044547), in a phytocoplex with antitumor activity (RF patent 2074731), etc. / 3 /.

 Calendula is used in the domestic pharmaceutical preparations Vitaon, Somaton / 2 /, and the pharmacopoeial preparation Rotokan (RF patent 1561262), which is a mixture of liquid extracts of chamomile, calendula and yarrow / 7 /.

 Evasive peony (marin root) - drugs work well in the treatment of gastric ulcer and duodenal ulcer, gastritis, have a bactericidal, analgesic effect. They also act as a sedative, anticonvulsant for neurasthenia, insomnia, and vascular disorders, and do not significantly affect blood pressure, respiration, and other body functions. In folk medicine, roots are used for diseases of the stomach, jaundice, diarrhea, bleeding, fever, bronchitis, cough, epilepsy, tuberculosis of the skin, purulent diseases of the ears, erosion and cancer of the uterus, diabetes, atherosclerosis. It is also used as an agent against prostatitis and impotence. It is used in an agent for the prevention and treatment of malignant neoplasms (RF patent 2044547), in a phytocomplex with antitumor activity (RF patent 2074731).

 Oregano and chamomile, also included in this target complex, are described above.

 EXAMPLE 2. To obtain 10 kg of the intermediate product of an additive intended to improve the activity of the cardiovascular system, provide sedation, relieve nervous excitement, irritability, insomnia, menopause, lower blood pressure, take 1.25 kg of licorice roots and rhizomes, 0.625 each kg of calamus marsh, elecampane, motherwort herb, about 1.875 kg of flowers or hawthorn fruit, 0.625 kg of valerian roots, dill and calendula flowers, 1.25 roots of evading peony and oregano grass, 0.625 kg of ro Ashka.

 In accordance with the invention, in order to regulate and normalize the activity of the gastrointestinal system, MILON, in addition to the main plant complex, also includes a complex of medicinal plants, including burdock roots, caraway seeds or anise fruits, lemon balm or peppermint grass, senna leaves or flax seeds , St. John's wort grass, valerian roots, yarrow grass taken in a ratio of 2: 2: 2: 1: 2: 1: 1.

 Plants included in the additional complex are briefly characterized by the following properties.

 Burdock - roots exhibit anti-inflammatory, choleretic, diuretic, diaphoretic, moderately analgesic effect, stimulate the formation of pancreatic enzymes, are a mild laxative, have anti-allergic, antimicrobial, antiseptic and disinfectant effects. Recommended for cardiovascular diseases, as well as nervous, gastrointestinal, female diseases. In folk medicine, they are also used for rheumatism, gout, kidney stones and bladder, gastritis and colitis with the usual constipation, diabetes. Recent studies by Japanese scientists have established the anti-cancer effect of burdock roots.

 It is used in collections: pulmonary (RF patent 2072862), for the treatment of diabetes mellitus (RF patent 2000802), etc. / 3 /.

 Used in complex preparations "Arth" and "Sig" of the company "Enrich" to relieve inflammation in the affected organ, increase defenses, regulate the effects on metabolism in women, reduce the effects of dysbiosis, etc. in the drug "Red Clover Plus" of the same company antitoxic, vitamin and other actions.

 Caraway seeds (fruits) - drugs have an antispasmodic effect, they are used to improve digestion, especially as a means of enhancing motility and reducing the processes of rotting and fermentation in the intestine. Contribute to the secretion of bronchi in case of respiratory tract disease. Assigned to adults and children suffering from stomach cramps, digestive disorders and flatulence, as an appetizing stimulant. Enhances milk separation in nursing mothers. It also has a choleretic effect, which allows it to be recommended for cholecystitis, pancreatitis. Tea from caraway is drunk with urinary retention due to prostate adenoma. It is used as a part of various fees: appetizing, gastric (astringent), carminative, sedative / 3 /.

 As an ingredient, it is included in phytopreparations "Vitaon", "Depuraflux", "Magolan", "Somaton" / 2 /.

 Anise (fruits) - pharmacological properties are determined by the high content of essential oil, which has anti-inflammatory, antispasmodic and expectorant properties. They are widely used in modern medicine for diseases of the respiratory system and for gastrointestinal diseases accompanied by digestive disorders, stomach and intestinal cramps, and deterioration of the secretion of the stomach and liver. Used in the treatment of functional sexual failure. It is used in various collections, breast and stomach teas / 3 /.

 Anis is an ingredient in the foreign drugs Altaleks, Bittner's Balm, Bromhexine 8, Bronchicum, Bronchosan, Musinum, Depuraflux, Magolan / 2 /.

 Melissa has long been used to stimulate appetite, eliminate vomiting, spasms of smooth muscles of internal organs, helps with biliary and renal colic. It has an anticonvulsant and analgesic effect, in particular for various neuralgia, headache, stomach pain, etc. It is used as a sedative for excessive irritability, hysteria, and insomnia. With heart diseases, the use of lemon balm reduces pain, shortness of breath, bouts of heart palpitations and lowering blood pressure. It is an ingredient in numerous fees, for example sedative (RF patent 2000795), for the treatment of cardiovascular diseases (RF patent 2082424), etc. / 3 /.

 Included as an ingredient in many imported herbal remedies / 2 /.

 Peppermint has a calming, antispasmodic, choleretic, antiseptic and anti-inflammatory effect. It is recommended for nausea, vomiting, digestive upset, angina pectoris, respiratory diseases, etc. It is included in many fees, in particular: for the treatment of cholecystitis (RF patents 1821199, 2003342, 2087154), gallstone disease (RF patent 1685457), insomnia (RF patent 2012347), sedative (RF patent 2000795), hypotensive (RF patents 1837887, 2019185), antispasmodic (RF patent 1792707), headaches (RF patent 2020951), for the treatment of cardiovascular diseases (RF patents 2000807, 2088250), for for treating diseases of the urinary system (RF patents 2001624, 2 098117, 2103003), for relieving alcohol cravings (RF patent 2097053), for the prevention and treatment of pregnant women toxicosis (RF patent 2001625), for the treatment of bursitis (RF patent 2076721), gastrointestinal (RF patent 2103001), chest (RF patent 2103002).

 Essential oil, isolated from the aboveground part, is a part of mint tablets, mint drops, tooth drops, Olimetin preparation, and pure menthol is a component of menthol oil, menthol pencil, Zelenin drops, Bormentol, tablets "Pectusina", "Validola", drops of "Eucatol", "Menovazin" / 8 /.

 Senna (cassia) is used in medical practice as a mild laxative to regulate bowel function (chronic atonic constipation, habitual), for constipation with diseases of the liver and gall bladder, as well as to soften stools with anal fissures, sphincteritis, hemorrhoids. In Chinese medicine, senna leaf in small doses is used as a means of improving appetite and digestion. Often used in fees / 3 /. It does not have an irritating effect and is well tolerated even with prolonged use.

 Included as an ingredient in a number of foreign herbal remedies / 2 /.

 Flax, St. John's wort, valerian, yarrow, included in this additional complex, are described above.

 EXAMPLE 3. To obtain 10 kg of the intermediate product of an additive designed to regulate and normalize the activity of the gastrointestinal system, take about 1.34 kg of licorice roots and rhizomes, 0.67 kg of calamus and elecampane, 1.34 kg of burdock roots and fruits cumin or anise, lemon balm or peppermint grass, 0.67 kg of senna leaves or flax seed, 1.34 kg of St. John's wort grass, 1.34 kg of valerian roots and yarrow grass.

 In accordance with the invention, the proposed MILONA supplement, in addition to the main one, additionally contains a complex of medicinal plants that promotes hepatoprotective action, normalizes the activity of the liver and gall bladder, including sandwort flowers, nettle leaves, dandelion roots, yarrow grass, chamomile flowers, St. John's wort, flowers calendula, dill, taken in a ratio of 3: 2: 2: 1: 1: 1: 2: 2.

 Sandy immortelle - flower preparations improve bile secretion, reduce the concentration of bile acids, improve the composition of bile, increase the tone of the gallbladder and blood vessels, stimulate the secretion of gastric juice and activate the secretory ability of the pancreas, increase urine output. The drugs are used for diseases of the liver, gall bladder and biliary tract, with cholecystitis, gallstone disease. They act antispasmodically on the smooth muscles of the intestinal wall, expand the blood vessels of the intestines. They have a disinfectant, hemostatic and astringent properties.

 In folk medicine, it is also used for diseases of the stomach, urogenital organs, cough, colds, hemoptysis, and bloody diarrhea.

 Pharmacopoeia drug "Flamin" is a dry concentrate of immortelle in the form of a powder used in tablet form.

 Immortelle is used in many collections as an ingredient: for the treatment of viral hepatitis (RF patent 2066998), cholecystitis (RF patents 2003342, 1821199, 2087154), choleretic agent (RF patent 1732999), gallstone disease (RF patent 1685457), hypertension (RF patent 1790945), general strengthening and anti-sclerotic action (RF patent 2020952), for the prevention and postoperative treatment of malignant neoplasms (RF patent 2027441), etc. / 3 /.

 Nettle is used as an anti-inflammatory, antimicrobial, hemostatic, blood-purifying, reparative, anti-atherosclerotic, diuretic, antipyretic, tonic, antitoxic agent, reduces blood sugar and enhances milk separation in women. It is rich in vitamins and minerals. It is used for atherosclerosis, iron deficiency anemia, cholecystitis, kidney stone disease, rheumatism, bronchitis, constipation, dyspepsia, gastritis, gastric ulcer and 12 duodenal ulcer, etc. It is widely used abroad as a stimulant of sexual function and a means for treating prostatitis.

 It is part of vitamin, gastric, pulmonary and hemostatic fees, in particular: hemostatic (RF patent 2000805), vascular (RF patent 2076729), cardiovascular (RF patent 2000807), cardiological (RF patent 2072863), pulmonary (RF patent 2072862 ), antihypertensive (RF patents 2092176, 1837887), antisclerotic (RF patent 2020952), to relieve alcohol cravings (RF patent 2097053), to cleanse the body (RF patent 2097052), for headaches (RF patent 2020951), for the treatment of atopic dermatitis in children (RF patent 1793927), diseases of the urinary system topics (RF patent 2001624), diabetes mellitus (RF patent 2000802), adnexitis (RF patent 2045955), prevention and treatment of dysbiosis (RF patent 2045955), etc. / 3 /.

Nettle is a part of the domestic pharmacopoeial drug "Allochol", as well as a number of foreign herbal remedies: "Menodoron", "Affix", "Koprivit", "Prostagut Forte", "Urtiron" and others. / 2 /
Dandelion is used as anti-inflammatory, diaphoretic, antipyretic, expectorant, anti-allergic, anti-sclerotic, choleretic, laxative, diuretic, antidiabetic, sedative, restorative, immunomodulating, anthelmintic. It lowers cholesterol, improves metabolism in the body. Stimulates milk production in nursing women. Dandelion is used as bitterness to stimulate appetite, with anacid gastritis, as a mild laxative for constipation, as a choleretic agent for diseases of the liver and gall bladder, as a sedative and diuretic for renal colic and gout.

 Often used in collections, for example: for the treatment of cholecystitis (RF patents 2003342, 2087154), gallstone disease (RF patent 1685457), vascular (RF patent 2076729), in a phytocomplex with antitumor activity (RF patent 2074731), etc. / 3 / .

 It is part of the phytopreparation "Amara drops" of the company "Weleda" (Switzerland), used to stimulate digestive functions in case of loss of appetite, impaired digestion and dyspeptic disorders; Enrich, a Hyp preparation, has an antibacterial, anti-inflammatory, regulatory effect on the female body.

 Yarrow, chamomile, St. John's wort, calendula, dill, included in the additional complex, are described above.

 EXAMPLE 4. To obtain 10 kg of the intermediate product of an additive designed to ensure hepatoprotective action, normalize the activity of the liver and gall bladder, take about 1.12 kg of licorice roots and rhizomes, 0.56 kg of calamus and elecampane, 1.68 kg of sandy immortelle flowers , 1.12 kg of nettle leaves and dandelion roots, 0.56 kg of yarrow grass, chamomile flowers and St. John's wort grass, 1.12 kg of calendula flowers and dill.

 In accordance with the invention, the proposed MILONA supplement, in addition to the main one, additionally contains a complex of medicinal plants that helps regulate and normalize the functioning of the urinary tract, including bearberry leaves, highlander grass, horsetail grass, juniper fruits, dill fruits, flax seeds, plantain leaves, taken in a ratio of 3: 3: 2: 2: 1: 1: 3.

 Bearberry has a pronounced diuretic, anti-inflammatory, disinfectant, astringent, anti-rheumatic effect. It is widely used in inflammatory diseases of the renal pelvis, bladder and urethritis. In folk medicine it is used for painful urination and urinary incontinence, as a sedative and hemostatic agent, for indigestion and diarrhea, to strengthen nerves, and for hypertension.

 Included in the fees, in particular: for the rehabilitation of the body after acute respiratory infections (RF patent 2020950), for the treatment and prevention of urological diseases (RF patents 2098118, 2103003), for the treatment of diseases of the urinary system (RF patent 2001624), for the treatment of cardiovascular diseases (RF patent 2000807) and others / 3 /.

 It is part of the "Herbal Diuretic" preparation of the company "Vitamin Power" (USA), which provides a strong diuretic, choleretic and antiseptic effect that improves the functioning of the kidneys and liver; "Diuretic tea" company "Quizda" (Austria); Uroflux tea of the Ron-Pulenck Rohrer company (USA-France), intended for the treatment of pyelitis, cystitis, urethritis; Enrich's Sfc preparation, which has an antibacterial effect, improves bowel and bladder function in diseases of the female genital area, etc.

 The highlander bird (knotweed) has astringent, hemostatic, anti-inflammatory, antimicrobial, antiseptic and diuretic properties, reduces bleeding of the mucous membranes, moderately reduces pressure, accelerates wound healing, increases immunity, increases the excretion of sodium and chlorine from the body, reduces the crystallization of mineral salts in the urine . It is widely used in the treatment of many diseases: gastritis and peptic ulcer of the stomach and duodenum, diarrhea, liver, kidney, bladder, salt metabolism disorders, etc.

 It is used for the treatment and prevention of pyelonephritis (RF patent 2088253), in many collections, in particular: antispasmodic (RF patent 1792707), for the treatment of adnexitis (RF patent 2045955), atopic dermatitis (RF patent 1793927), gastrointestinal diseases (RF patent 2077332), for the prevention and postoperative treatment of malignant neoplasms (RF patents 2027441, 2044547) and others / 3 /.

 Horsetail has anti-inflammatory, antimicrobial, hemostatic, diuretic, wound healing properties, enhances the detoxifying and immune properties of the body, prevents the formation of urinary stones. As an effective diuretic, it is recommended for inflammation of the bladder, diseases of the cardiovascular system, and atherosclerosis of the vessels of the heart and brain. In folk medicine it is used for rheumatism, gout, urolithiasis and cholelithiasis, respiratory diseases and as a hemostatic agent for hemorrhoids and heavy menstruation. Contraindicated in nephritis and nephrosis.

 It is used in many collections, in particular: for the treatment of hypothalamic syndrome in women (RF patent 2101024), treatment and prevention of urological diseases (RF patents 2098118, 2098116), diabetes mellitus (RF patent 1456156), gallstone disease (RF patent 2045956), cholecystitis and gallstone disease (RF patents 2044546, 1821199), for detoxification of the body (RF patent 2032420), for the prevention and postoperative treatment of malignant neoplasms (RF patents 2027441, 2044547), serves as an ingredient in an agent with anti-blast activity (RF patent 2 008909) and others. / 3 /.

 Horsetail is an ingredient in the Phytolysin preparation of the company Ciech-Polfa (Poland), intended for the treatment of nephrolithiasis, urinary tract infection, and prevention of crystallization of salts in the urine.

 Juniper (fruits) - has a strong diuretic, choleretic, antipyretic, expectorant, anti-inflammatory, analgesic and antimicrobial effect, stimulates digestion. It is used for diseases of the respiratory tract to stimulate appetite and improve digestion. Fruits are contraindicated in acute kidney disease, gastric ulcer and duodenal ulcer, acute gastritis and colitis.

 Included in many fees / 3 /. It is also part of the Amara drops company Veleda (Switzerland), designed to stimulate digestion in case of loss of appetite, impaired digestion and dyspeptic disorders; the drug "Herbal Diuretic" (USA); Enrich, a Hyp preparation that has an antibacterial, anti-inflammatory and regulatory effect on the female body.

 Other ingredients of the specified target complex - dill, flax, plantain - are described above.

 EXAMPLE 5. To obtain 10 kg of the intermediate product of an additive designed to regulate and normalize the functioning of the urinary tract, take about 1.06 kg of licorice roots and rhizomes, 0.53 kg of calamus and elecampane, 1.59 kg of bearberry leaves and bird mountain grass , 1.06 kg of dill and horsetail, 0.53 kg of flax seed and plantain leaves, 1.59 kg of juniper fruits.

 In accordance with the invention, the proposed MILONA supplement, in addition to the main one, additionally contains a complex of medicinal plants that promotes an antisclerotic, cardiotonic, vasodilating effect, including flowers or fruits of hawthorn, bearberry leaves, calendula flowers, plantain leaves, motherwort grass, dill fruits, horsetail grass, St. John's wort grass, yarrow grass, thallus kelp, taken in the ratio 3: 1: 2: 1: 1: 2: 2: 2: 2: 2.

 Laminaria (seaweed) is an iodine that has a high iodine content, due to which it is widely used in medicine to treat and prevent the development of atherosclerosis and treat goiter. Often used as a laxative. Useful for obesity, thrombophlebitis. It has contraindications for diseases in which iodine preparations cannot be used: pulmonary tuberculosis, nephritis and nephrosis, urticaria, as well as pregnant women. Contraindicated in certain gastrointestinal diseases. However, in small doses characteristic of food additives, these contraindications are not significant.

 Laminaria serves as a raw material for the production of a laxative (patent of the Russian Federation 1736502), in the collection for the regulation of metabolism (patent of the Russian Federation 2103004), in the collection of treatment for diabetes (patent of the Russian Federation 2000802), means for the prevention of cancer "Klamin" (patent of the Russian Federation 2034560), integrated food additives radioprotective action (RF patent 2077231), biologically active additives "Seafood" (RF patent 2070812).

 It is part of the "Male Virility Pack" and "Zip Aid" preparations of Enrich (USA), designed to increase male potency and prevent prostate adenoma; drugs "Red Clover Plus" and "Ex Press" of the same company antitoxic, vitamin, increases defenses and other actions.

 Other ingredients of this additional complex - hawthorn, bearberry, calendula, plantain, motherwort, dill, horsetail, St. John's wort, yarrow - are described above.

 EXAMPLE 6. To obtain 10 kg of the intermediate product additives designed to provide antisclerotic, cardiotonic, vasodilating action, take about 0.9 kg of licorice roots and rhizomes, 0.45 kg of calamus and elecampane, 1.35 kg of flowers or fruits of hawthorn, 0 , 45 kg of bearberry leaves, 0.9 kg of marigold flowers, 0.45 kg of plantain leaves and motherwort grass, 0.9 dill fruits, horsetail grass, St. John's wort grass, yarrow grass, thallus kelp.

 In accordance with the invention, the proposed supplement “MILONA”, in addition to the main one, additionally contains a complex of medicinal plants to stimulate the brain, improve memory, facilitate attention concentration, including incense leaves, rhizomes and roots of rhizomes, rhizomes and roots of Rhodiola rosea, and L-glutamic acid taken in the ratio 1: 2: 1: 4.

 Badan - extracts from leaves and rhizomes possess astringent, hemostatic, analgesic, anti-febrile, anti-inflammatory, diuretic and antiseptic effects. Badana medications lower blood pressure and increase heart rate. The extract from the leaves of badan has antiaggressive, antihypoxic and stimulating working capacity action / 9 /. A drug with anticancer activity was isolated from badan. It is widely used in folk medicine for inflammatory diseases of the gastrointestinal tract, dysentery, female diseases, headache, fever, pneumonia, goiter, urinary tract diseases, kidney diseases, etc. Tea made from frankincense leaves ("Chagir tea") has invigorating and restorative properties.

 Based on the leaves of badan, a drug with adaptogenic effect was created (RF patent 2076727). The roots were used in the collection of general strengthening and anti-sclerotic action (RF patent 2020952), in the therapeutic agent Pantogram (RF patent 2100938), in a substance with a radioprotective effect (RF patent 2034558), in a tonic drink (RF patent 2060015).

 Leuzea (maral root) belongs to the group of adaptogens. It has a pronounced activating effect on the central nervous system. The drugs have a tonic, stimulating effect, increase efficiency during mental and physical overwork, stimulate appetite, improve blood circulation, and increase blood pressure. They help well with drowsiness, general exhaustion, work in extreme conditions and situations, an asthenodepressive state, sexual impotence, and chronic alcoholism. Useful for anemia, anemia, various poisonings, oncological diseases during treatment with cytostatics.

 Used in antihypertensive herbal tea (RF patent 2092176), is included in the biostimulating agent (RF patent 1826910), a tool for restoring and stimulating the endocrine and immune systems (RF patent 1836094), in the urological collection (RF patent 2103003). It is an ingredient of adaptogenic food additives (RF patent 2092076).

 The drug Leuseya of the Slovakopharm company is indicated for neurosis, anxiety, weakness, excessive physical and mental stress, decreased potency, and rehabilitation after serious illness. For the same purposes, as well as in alcoholism, impaired protein metabolism, for the stimulation of immunity, prevention and treatment of prostatitis, the drug Leveton of Bifarm firm (RF) is used.

 Rhodiola rosea (golden root) has a pronounced psychostimulating and adaptogenic effect. Drugs improve mental performance, contribute to a better course of oxidative processes and maintaining a high level of brain energy potential / 10 /. It activates the central nervous system well, therefore it is used for asthenic conditions, neurasthenia, and vegetovascular dystonia. Strengthens the work of muscles and helps to restore their strength after overwork. It is recommended as a stimulant for physical and nervous exhaustion, fatigue, headaches, and neurosis. It is used in the treatment of diabetes mellitus, with hypotension, anemia, anemia, as an antitoxic agent for various poisonings, as a stimulator of the cardiovascular system, as a stimulant of sexual function, in atonic conditions of the uterus, as an anti-radiation agent.

 It is used, in particular, in an agent for the restoration and stimulation of the endocrine and immune systems (RF patent 1836090). It is an ingredient of adaptogenic food additives (RF patent 2092076).

 L-glutamic acid is a substance often called "brain amino acid", approved for use in medicine as a therapeutic agent for stimulating oxidative processes and as a detoxification agent, as well as in the food industry as an additive that enhances taste and aroma. This natural amino acid helps the brain, supports the metabolism that occurs in it, improves mental abilities, helps the various systems of the body function, is a source of energy for the immune system, improves memory and mood, stimulates muscle protein synthesis, a process that the body needs, especially with age, when he is aging and muscle tissue lose elasticity / 4, p. 40 /.

 EXAMPLE 7. To obtain 10 kg of the intermediate product of an additive designed to stimulate brain function, improve memory, and facilitate concentration, take about 1.66 kg of licorice roots and rhizomes, 0.83 kg of calamus, elecampane and frankincense leaves, 1.66 kg rhizomes and roots of Leuzea, 0.83 kg of the roots and rhizomes of Rhodiola rosea, 3.32 kg of L-glutamic acid.

 In accordance with the invention, the proposed MILONA supplement, in addition to the main one, additionally contains a complex of medicinal plants for the improvement of the female genital area, including the roots and rhizomes of incense, yarrow grass, mountaineer bird grass, motherwort grass taken in a ratio of 1: 2: 3: 3.

 The ingredients of this additional complex are described above.

 EXAMPLE 8. To obtain 10 kg of the intermediate product of an additive intended for the improvement of the female genital area, take about 1.54 kg of licorice roots and rhizomes, 0.77 kg of calamus, elecampane and frankincense, 1.54 kg of yarrow herb, 2.37 each kg grass of the mountaineer bird's and grass motherwort.

 In accordance with the invention, the proposed supplement “MILONA”, in addition to the main one, additionally contains a complex of medicinal plants for improving the male genital area, including the roots and rhizomes of Rhodiola rosea or safflower levzea, the roots and rhizomes of evading peony, St. John's wort, sage grass, anise fruits, nettle leaves taken in the ratio 1: 1: 1: 2: 2: 3.

 Sage has astringent, anti-inflammatory, disinfectant, diuretic, general strengthening actions. In addition, it has a calming, analgesic, expectorant, carminative, emollient, hemostatic effect. Reduces sweating and lactation, enhances the activity of the sex glands. It also has an antitumor effect. In folk medicine, sage infusion is drunk for laryngitis, tracheitis, bronchitis, inflammation of the bladder, diseases of the liver and gall bladder, diseases of the gastrointestinal tract (gastritis with decreased secretion of gastric juice, gastric ulcer and 12 duodenal ulcer, intestinal cramps, etc. .). It is part of many fees, in particular: for the treatment of cardiovascular diseases (RF patent 2000807), general strengthening and anti-sclerotic action (RF patent 2020952), for the treatment of chronic bronchitis (RF patent 2013094), for the treatment of diseases of the urinary system (RF patent 2001624 ), to cleanse the body (RF patent 2097052), to relieve craving for alcoholism (RF patent 2097053), for the treatment of hypothalamic syndrome in women (RF patent 2101024), in an agent with antimicrobial activity.

 Sage is a part of the Amara drops preparation of Veleda company (Switzerland) designed to stimulate digestion in case of loss of appetite, indigestion and dyspeptic disorders; Altalex preparation of Lek company (Slovenia), used for pain in the stomach, abdomen , has a calming effect on nervous agitation, insomnia, anxiety, etc.; the drug "Fitolizin" of the company "Ciech-Polfa" (Poland), used for nephrourolithiasis, urinary tract infections, prevention of crystallization of salts in the urine.

 Rhodiola rosea, safflower levzea, evasive peony, St. John's wort, anise, nettle, used in this additional complex, are described above.

 EXAMPLE 9. To obtain 10 kg of the intermediate product of the supplement intended for the improvement of the male genital area, take about 1.42 kg of licorice roots and rhizomes, 0.71 kg of calamus, elecampane, Rhodiola rosea or safflower levzea, evading peony, St. John's wort grass, 1.42 kg of sage grass and anise fruits, 2.13 kg of nettle leaves.

 In accordance with the invention, the proposed MILONA supplement, in addition to the main one, additionally contains a complex of medicinal plants for providing a preventive and general strengthening effect, including rose hips, nettle leaves, hawthorn fruits, common mountain ash fruits, chokeberry fruits taken in a ratio of 5: 2: 3 : 1: 2, as well as ascorbic acid, β-carotene, α-tocopherol, the average values of which are taken in the ratio of 0.16: 0.01: 0.13.

 Rosehip - fruits are widely used as vitamin raw materials for the prevention and treatment of diseases associated with a lack of vitamins in the body, primarily vitamin C, in case of exhaustion and anemia. It has a diuretic, antimicrobial, anti-inflammatory, anti-allergic, restorative, as well as choleretic, sedative, laxative, hematopoietic, anti-sclerotic action. Often used for bleeding of various origins, hemophilia, hemorrhagic diathesis, after undergoing surgical operations, with prolonged physical and nervous stress, with atherosclerosis, inflammation of the bronchi and lungs, tuberculosis, gastritis with low acidity, as well as with peptic ulcer and duodenal ulcer guts. Due to the diuretic effect, rosehip is used for diseases of the kidneys, bladder, edema.

 The pharmaceutical preparation "Holosas", obtained from rose hips, is used to treat inflammatory diseases of the liver and gall bladder.

 Based on the use of the properties of rose hips, preventive and restorative agents have been developed (RF patents 2100019, 2094050), used in a substance with a radioprotective effect (RF patent 2034558). Its fruits are part of many fees, in particular: for the treatment and prevention of thrombosis (RF patent 2104024), malignant neoplasms (RF patent 2044547), chronic pyelonephritis (RF patents 2026079, 2082418), chronic cholecystitis (RF patent 2087154), nephropathy ( RF patent 2063765), sedative and antihypertensive effect (RF patents 2019185, 2092176), diabetes mellitus (RF patents 1697820, 1456156, 2000802), to cleanse the body (RF patent 2097052), regulate metabolism (RF patent 2103004), to relieve traction to alcohol (RF patent 2097053), disorders of the genitourinary system (US Pat ent of the Russian Federation 2098117), toxicosis of pregnant women (RF patent 2001625), for removing gallstones (RF patent 2097054). It is an ingredient of adaptogenic food additives (RF patent 2092076), as well as Energoton, which has a tonic and restorative effect (RF patent 2018316).

 It is part of the preparations: "Bo Than Hoan" of the company "Bao Long" (Vietnam) for the treatment of male diseases, cystitis, recovery of strength; "Kanefron" company "Bionorika" (Germany) for the treatment of diseases of the bladder, kidneys, with nephrolithiasis, etc. / 2 /.

 Mountain ash ordinary - the fruits have a diuretic, choleretic, mild hypotensive, antimicrobial, restorative properties, regulate salt metabolism. Extremely rich in carotene, flavonoids (substances of P-vitamin action), ascorbic acid, trace elements, etc. / 10 /. It has a hemostatic, antisclerotic, diaphoretic, astringent, laxative, carminative action. It is used in various vitamin collections: with exhaustion and anemia, with hypo- and vitamin deficiencies, with kidney stones and nephritis, gout, arthritis, rheumatism, cholecystitis, to activate physical and mental performance. It is used to treat asthenoneurotic conditions (RF patent 2101025).

 Chokeberry - fruits have anti-inflammatory, strong astringent, laxative, hemostatic effect. It is used to normalize metabolism, improve the activity of the cardiovascular system as a hypotensive, diuretic and anti-atherosclerotic agent. It takes first place among plants in the content of vitamins P and C / 3 /. The substance obtained from chokeberry (RF patent 2049473), has a radioprotective effect. It is an ingredient of Energoton, which has a tonic and restorative effect (RF patent 2018316).

 Nettle and hawthorn, which are part of this additional complex of medicinal plants, are described above.

 Vitamin C (ascorbic acid) plays a large role in the metabolic processes of the body: it stimulates oxidative processes, activates the work of various enzymes, normalizes the metabolism of carbohydrates, and improves glucose absorption in the intestines. The absence or deficiency of vitamin C in food leads to serious diseases: decreased immunity and vitamin deficiency, including severe form (scurvy), hemorrhages in the skin, muscles, internal organs, joints due to increased capillary permeability. In latent forms of vitamin C deficiency, especially in spring, rapid fatigue, decreased performance, muscle weakness, decreased appetite, and reduced body resistance to infections are observed. The human need for vitamin C is 70-100 mg per day. Ascorbic acid prevents obesity of the liver, increases the protective functions of the body, inhibits the development of atherosclerosis, increases the release of cholesterol through the intestines and lowers its level in the blood, promotes absorption of iron, and stimulates blood formation. It is proved that vitamin C normalizes the activity of sex hormones, which is especially important for the elderly, helps to increase the body's immunity to infections.

 β-carotene (provitamin A) is found in many vegetables and fruits, turning in the liver into vitamin A. It has an antioxidant effect. Vitamin A is one of the most important growth factors, ensures the normal activity of the organs of vision, increases the body's resistance to diseases of the mucous membranes of the respiratory tract, digestive tract, urinary tract.

 α-tocopherol (vitamin E) is found in large quantities in wheat germ, grains of all plants. It is a strong antioxidant. Provides maturation of germ cells, contributes to the preservation of pregnancy. It has a vasodilating effect, so it is used for hypertension, angina pectoris, as well as for violations of the function of the sex glands, skin, liver, inflammatory diseases of the retina, as well as for neuromuscular dystrophies.

 An additional introduction of vitamins A, C and E to the target complex “MILONS” of pharmacopeia preparations allows them to be brought up to the daily norm recommended by the Ministry of Health, determined by the physiological need of the body.

 EXAMPLE 10. To obtain 10 kg of the intermediate product of an additive intended to provide a preventive and general strengthening effect, take about 1.16 kg of licorice roots and rhizomes, 0.58 kg of calamus and elecampane, 2.9 kg of rose hips, 1.16 kg of leaves nettles, 1.74 kg of fruits of hawthorn, 0.58 kg of fruits of mountain ash, 1.16 kg of fruits of mountain ash, as well as 0.093 kg of ascorbic acid, 0.006 β-carotene, 0.075 kg of α-tocopherol.

 The above-described compositions of medicinal plants in the indicated quantitative proportions can be taken orally as a biologically active food supplement in powder form. In this consumer form, the powders may be packaged by the manufacturer in capsules or vials.

 However, it seems more convenient dosage form consumer formulations in the form of tablets. To ensure this possibility and to obtain high quality tablets, auxiliary (technological) ingredients should be added to the powdered mixture of medicinal plants.

 Aerosil and / or talc are technological additives that increase the strength of tablets. Glucose improves the organoleptic qualities of tablets. Starch and microcrystalline cellulose are also technological fillers.

 It has been experimentally established that the optimal quantitative ratio of vegetable powder, aerosil and / or talc, glucose and / or starch and / or microcrystalline cellulose should be 10: 0.5: 2.5.

 EXAMPLE 11. To prepare a mixture suitable for further tabletting, take 10 kg of a powder mixture of any of the above compositions, 0.5 kg of aerosil and / or talc, 2.5 kg of glucose and / or starch and / or microcrystalline cellulose. The mixture is thoroughly mixed and subjected to tableting.

 The MILON dietary supplement can be used with the ingredients presented above. However, in accordance with the invention, its effectiveness can be further increased through the use of a natural organomineral substrate. Strengthening the action of medicinal plants and replenishing the body with macro- and microelements in the MILON dietary supplement can be achieved by adding to the main and additional complexes of the organomineral substrate in the form of a mummy extract in a ratio of 10: (0.5-1.0).

 The prerequisites for this are the well-known unique healing properties of the mummy as a natural biostimulant, found, in particular, in the Altai Mountains ("Brashun") and from ancient times used by many peoples. Currently, the mummy is used to treat a wide range of diseases, although its nature and the mechanism of biological activity are not fully understood / 11, 12 /.

 Mummies are usually used in the form of a dry extract purified in various ways (RF patents 2001618, 2020943 2050801, 2055585, 2068264, 2072850, 2097980). In this form, it is a resinous product containing 28 chemical elements, 10 various metal oxides, 6 amino acids, a number of B, C, A vitamins, essential oils, and resinous substances.

 Mumiye has a high immunomodulating, antiseptic, anti-inflammatory, hepatoprotective activity, which allows it to be successfully used for the prevention and treatment of infectious diseases, lesions and complications. The effect of its use can be explained by the addition of a direct effect on the causative agent of the disease and the stimulation of the protective and regenerative abilities of the body. Unlike antibiotics, the mummy has a wide spectrum of action, it does not suppress, but rather stimulates the immune system, does not cause the formation of allergies, inhibits the development of antibiotic-resistant forms of pathogens, and does not have a toxic effect on the body. In this regard, in some cases, the mummy can serve as an alternative to antibiotics, in particular, for the treatment of pregnant women and children in whom antibiotics can cause side effects and complications. Immunostimulating properties of mummies can reduce the incidence of influenza and acute respiratory infections. The same properties may explain the positive effect of the use of mummies in the treatment of certain tumors. Mummy causes accelerated regeneration of damaged nerve trunks, heart muscle and other tissues, stimulates hematopoiesis, increases the ability of the liver to neutralize toxins, which allows the mummy to be used to combat the side effects of chemotherapy in neoplasms, some poisoning, radiation therapy, when working in harmful conditions. The use of mummies leads to a certain decrease in blood coagulability, which serves as the basis for its successful use in the treatment of patients with thrombophlebitis of the veins of the lower extremities. The adaptogenic effect of the mummy determines its use as a means of having general strengthening, tonic, and enhancing the activity of the genital organs properties.

 Most often, the mummy is used to treat bone fractures, dislocations, bruises, burns and non-healing wounds, skin diseases; for the treatment of poisoning, peptic ulcer of the stomach and duodenum, gastritis, colitis, cholecystitis, liver, kidney, spleen, diseases of the bladder; with diseases of the respiratory system, asthma; with sclerosis, myocardial infarction; with anemia, radiation sickness, leukemia; with exhaustion, weakening of the body in old age; with diabetes, thrombophlebitis, purulent otitis media, tonsillitis; with periodontal disease; in the treatment of diseases of the peripheral nervous system: radiculitis, plexitis, neuritis, neuralgia, inflammatory processes of various localization. Mummies are also used for many other diseases.

 The noted healing properties of the mummy have found use in a number of dietary supplements, including it as an ingredient. So known food product (RF patent 1804305), in which the mummy is used in conjunction with licorice root, beekeeping products and groundhog fat; in a food product (RF patent 2061389) mummy is used in conjunction with honey and oil extract of California worms; in the agent for apitherapy and apiprophylaxis (RF patent 2033798), the mummy extract is used in conjunction with beekeeping products, antlers extract and liquid plant extracts: belladonna, hawthorn, buckthorn, licorice, valerian, and various extracts are administered depending on the desired direction of the pharmacological action; In the Kok-Sai healing product, the mummy is used together with sea buckthorn to stimulate metabolism, increase mental and physical performance, and treat various respiratory and digestive diseases (RF patent 2101021).

 Closest to the proposed technical solution for using the properties of mummies is the drug "Barakhshin" developed by the authors of the present invention, which, taking into account the conclusion of the Commission on Natural Products and Homeopathic Medicines of the Pharmacological Committee of the Russian Federation 204/4 from 04.24.96, was recognized as a biologically active food supplement and recommended by the Goskomsanepidnadzor of the Russian Federation for the manufacture, sale and use (certificate 72 / e-252 of 09.10.96).

 "Barakhshin" is a tablet preparation in which the content of the Altai purified mummy is 0.02 g in 1 tablet weighing 0.2 g, which is 10 times less than the daily therapeutic dose of the mummy, which, according to a number of sources, is 0.2 g. Second the ingredient in the tablets is microcrystalline cellulose, which is a high-purity plant (cotton) fiber, dietary fiber of which has established itself as an excellent enterosorbent that promotes the binding and excretion of the gastrointestinal tract kta cholesterol, harmful to the body chemicals, toxins, carcinogens, radionuclides. At the same time, it is harmless to the body and is well compatible with human nutrition. Dietary fiber affects the microflora, increasing the total number of bacteria useful for the intestine, inhibiting the bacterial decomposition of the usual components of the intestinal contents into fragments with potential carcinogenic activity and thereby protecting the colon mucosa from malignant degeneration.

 In accordance with the present invention, the mummy extract is introduced into MILON in a ratio of (0.5-1.0): 10 to plant components.

 The main purpose of introducing mummy into a dietary supplement is to fill in the body the deficiency of micro and macro elements that occurs in a significant part of the population of our country, as well as introduce other vital bioactive components into the body that contribute to its healing and prevention of various painful conditions. The amount of mummy added to the supplement does not exceed the norms established for biologically active food additives, however, compared with Barakhshin, its effectiveness on the body is much higher. This is due to the fact that the powders of herbs used in conjunction with the mummy, in addition to the fiber functions necessary for the normal functioning of the gastrointestinal tract, carry medicinally active substances in small doses that synergistically interact with the complex composition of the mummy. It has long been accepted / 11, 12 / for mummies together with juices and decoctions of herbs (dandelion, parsley, blueberries, cumin, carrots, etc.), pink or peach oil, juice of sour grapes or persimmons, honey, etc., since the mummy, in addition to its own healing, increased the therapeutic effect of related plants and products of their natural processing.

 Biologically active food supplement "MILONA" according to the invention is made in the following way.

 Each ingredient in the form of dried medicinal herbs, fruits, roots and rhizomes is subjected to thorough grinding to a finely divided powder state with particle sizes of 500 μm or less, which is ensured by sieving the powders through a grid with an appropriate cell size. The powders are mixed in accordance with the proposed formulations of the main and additional complexes of medicinal plants, auxiliary components are added and mixed thoroughly. Then, if necessary, the composition can be introduced mummy extract in a ratio of 10: (0.5-1.0), after which the mixture is subjected to tabletting or encapsulation. The resulting tablets are placed in appropriate packaging, for example, sealed vials, and then the latter in the appropriate container.

 Packages with finished products are placed in the chamber of a special x-ray unit in which they are subjected to sterilization treatment in accordance with the selected energy parameters of the x-ray beam and dose-dependent parameters of irradiation. X-ray sterilization of food products is carried out in accordance with international authorization and recommendations set forth in the document: "Food Irradiation Newsletter. Joint FAO / IAEA Division of Nuclear Techniques in Food and Agriculture. International Atomic Energy, Vienna, Austria, 1995". The sterilization parameters are selected in the range of energies of 0.3-1.0 MeV and an absorbed dose of 0.7-10.0 kGy. Monitoring of the achieved level of sterilization and optimization of sterilization modes is carried out according to a specialized laboratory with appropriate accreditation.

 This technological scheme is adopted in the practice of the existing production of the pharmaceutical company Evalar. However, it can be somewhat different: the obtained powdery ingredients can be subjected to X-ray sterilization separately, after which the process of mixing, tabletting and packaging of the finished product is carried out. With this variant of the technological scheme, increased demands are made on ensuring hygienic purity of the intermediate technological phases of the preparation of the drug.

Thus, the proposed biologically active food supplement "MILONA" and the method for its preparation are characterized by the following advantages:
the supplement is a non-drug treatment and health-improving complex of natural products, including medicinal herbs, vitamins, minerals and having a multilateral effect both on the body as a whole and on its individual functions and systems;
selection, layout of the active substances in the preparation and their dosage are selected from the condition of providing a gentle, gentle effect on the body, providing a preventive and healing effect with a minimum of contraindications;
the form of preparation of the additive provides the convenience of taking the drug and its storage in all conditions of use;
the technology for producing the additive guarantees the preservation in it of a maximum of substances useful to the body that are present in plant and organomineral raw materials while ensuring a high level of microbiological purity.

 The preparations of the MILONA series underwent clinical, sanitary-chemical and sanitary-microbiological tests at the Head Food Testing Center at the Institute of Nutrition RAMS, on the basis of which the Ministry of Health of the Russian Federation issued registration certificates approved by the Chief State Sanitary Doctor of the Russian Federation, allowing their serial production.

LITERATURE
1. Biologically active food supplements. Handbook of the company "Emrion" (USA), M., Alfa-Med, 1996, 128 pp.

 2. Mikhailov IV. Modern phytotherapeutic drugs. Directory. M., StarKo Publishing House, 1997, 144 pp.

 3. Sokolov S. Ya., Zamotaev I.P. Handbook of medicinal plants (Phytotherapy). M., Medicine, 1990, 464s.

 4. Information collection "Urology" about the products of the company "Enrich". Samara, 1996.

 5. Grave N.P. Travnik. M., VSV-Sphinx, 1997, 320 pp.

 6. Pashinsky V. G. Plants in the treatment and prevention of diseases. Tomsk, Publishing House Tom. University, 1989, 208 pp.

 7. Mashkovsky M. D. Medicines. Kharkov, Torsing, 1997.

 8. Minaev V. G. Medicinal plants of Siberia. Novosibirsk, Nauka, 1991, 431 pp.

 9. Lavrenova G. V. Herbal medicine. SPb. , 000 "SMIO Press", "Diamond" LLP, 1996, T. 1, 480 p.

 10. Krylov G.V. et al. Green pharmacy. Kemerovo books. Publishing House, 1993, 334 pp.

 11. Savinykh M. I. All about the mummy. Materials and results. Novokuznetsk, Sibdalmumie, 1992, 129 p.

 12. Altimyshev A. A., Korchubekov B. K. What do we know about the mummy (Arkhar-Tash). F., Mektep, 1979, 76 p.

Claims (14)

 1. A therapeutic and health-improving biologically active food supplement containing a multicomponent mixture of medicinal plants, characterized in that the additive contains a basic complex consisting of plants that have a multilateral physiological effect on the body, and an additional complex of plants designed to enhance individual effects and reactions of the body , while the main complex includes the roots and rhizomes of licorice, calamus marsh and elecampane, taken in a ratio of 2: 1: 1.  2. The supplement according to claim 1, characterized in that the additional complex intended to enhance the action on the respiratory system includes the leaves of the large plantain, marjoram grass, thyme grass, St. John's wort grass, yarrow grass, flax seeds, and chamomile flowers taken in the ratio 2 : 4: 2: 2: 2: 2: 2.  3. The supplement according to claim 1, characterized in that the additional complex intended to improve the activity of the cardiovascular system, provide sedation, relieve nervous excitement, irritability, insomnia, menopause, lower blood pressure, includes motherwort grass, flowers or fruits hawthorn, valerian roots, dill fruits, calendula flowers, evading peony roots, oregano grass, chamomile flowers taken in a ratio of 1: 3: 1: 1: 1: 2: 2: 1.  4. The supplement according to claim 1, characterized in that the additional complex designed to regulate and normalize the activity of the gastrointestinal system includes burdock roots, caraway seeds or anise fruits, lemon balm or peppermint grass, senna leaves or flax seeds, St. John's wort grass, valerian roots, yarrow grass, taken in a ratio of 2: 2: 2: 1: 2: 1: 1.  5. The supplement according to claim 1, characterized in that the additional complex designed to provide hepatoprotective effects, normalize the activity of the liver and gall bladder, includes immortelle sand flowers, nettle leaves, dandelion roots, yarrow grass, chamomile flowers, St. John's wort grass, marigold flowers , fruits of dill, taken in a ratio of 3: 2: 2: 1: 1: 1: 2: 2.  6. The supplement according to claim 1, characterized in that the additional complex designed to regulate and normalize the functioning of the urinary tract includes bearberry leaves, mountaineer grass, dill fruits, horsetail grass, flax seeds, plantain leaves, juniper fruits taken in the ratio 3: 3: 2: 2: 1: 1: 3.  7. The supplement according to claim 1, characterized in that the additional complex designed to provide an anti-sclerotic, cardiotonic, vasodilating effect includes flowers or fruits of hawthorn, bearberry leaves, calendula flowers, plantain leaves, motherwort grass, dill fruits, horsetail grass, grass St. John's wort, yarrow herb, thallus kelp, taken in a ratio of 3: 1: 2: 1: 1: 2: 2: 2: 2: 2.  8. The supplement according to claim 1, characterized in that the additional complex, designed to stimulate the brain, improve memory, facilitate concentration, includes frankincense leaves, rhizomes and roots of rhizomes, rhizomes and roots of Rhodiola rosea, as well as L-glutamic acid, taken in a ratio of 1: 2: 1: 4.  9. The supplement according to claim 1, characterized in that the additional complex intended for the improvement of the female genital area includes the roots and rhizomes of frankincense, yarrow grass, mountaineer bird grass, motherwort grass, taken in a ratio of 1: 2: 3: 3.  10. The supplement according to claim 1, characterized in that the additional complex intended for improving the male genital area includes the rhizomes of Rhodiola rosea or safflower levzea, the roots and rhizomes of the peony evading, St. John's wort, sage grass, anise fruits, nettle leaves taken in 1: 1: 1: 2: 2: 3 ratio.  11. The supplement according to claim 1, characterized in that the additional complex designed to provide a preventive and restorative effect includes rose hips, nettle leaves, hawthorn fruits, common rowan fruits, aronia fruits, taken in a ratio of 5: 2: 3: 1: 2, as well as ascorbic acid, β-carotene, α-tocopherol, the average values of which are taken in the ratio of 0.16: 0.01: 0.13.  12. The additive according to any one of paragraphs. 1-11, characterized in that, as auxiliary substances, its composition contains aerosil and / or talc, glucose, and / or starch, and / or microcrystalline cellulose, taken in a ratio of 10: 0.5: 2.5.  13. The additive according to any one of paragraphs. 1-11, characterized in that to enhance the action of medicinal plants and replenish the body with macro- and microelements, the main and additional complexes can be supplemented with an organomineral substrate, in particular a mummy extract in a ratio of 10: (0.5-1.0).  14. A method of obtaining a health-improving biologically active food supplement according to claim 1, which means that the raw materials are crushed to a powder state with particle sizes less than 500 microns, auxiliary components are added, tablets or capsules are formed and they are exposed to the sterilizing factor in the form x-ray radiation with an energy of 0.3-1.0 MeV and an absorbed dose of 0.7-10.0 kGy, or when forming tablets using ingredients that are previously sterilized by the specified physical factor.