CN1506047A - Effervescent vitamin C granule and its prepn - Google Patents
Effervescent vitamin C granule and its prepn Download PDFInfo
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- CN1506047A CN1506047A CNA021398062A CN02139806A CN1506047A CN 1506047 A CN1506047 A CN 1506047A CN A021398062 A CNA021398062 A CN A021398062A CN 02139806 A CN02139806 A CN 02139806A CN 1506047 A CN1506047 A CN 1506047A
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- vitamin
- citric acid
- lemon yellow
- mix homogeneously
- granule
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Abstract
The effervescent vitamin C granule includes main material vitamin C and supplementary material including sodium bicarbonate, sugar powder, saccharin sodium, citric acid, lemon yellow and edible essence. The preparation process includes grinding citric acid into fine powder, drying, mixing vitamin C and citric acid powder, adding dilute ethanol solution of lemon yellow, pelletizing the mixture and drying to form the acid material; mixing sodium bicarbonate, sugar powder, water solution of lemon yellow and saccharin sodium, and edible essence, pelletizing the mixture and drying to form the alkali material; and mixing the acid material and the alkali material. The effervescent vitamin C granule of the present invention is water soluble, aromatic, sour and sweet, tasty and high in absorption speed, and is especially suitable for infant to take.
Description
Technical field
The present invention relates to a kind of vitamin C fizzy granule and preparation method thereof.
Background technology
Vitamin C is usually used in the clinical treatment vitamin C deficiency, also is the auxiliary treatment medicine of multiple disease simultaneously, is widely used in clinical.Present ascorbic dosage form is mainly injection, tablet, and injection type uses inconvenient, must could inject through hospital; Tablet then exists mouthfeel not good enough, and especially children's is difficult to accept.
Summary of the invention
The present invention aims to provide a kind of steady quality, taking convenience, easily dissolving, do not need heating and stirring during use, instant-drink, absorb fast, timely vitimin supplement C, mouthfeel is good, can also quench the thirst by expelling summer-heat, appetite stimulator, the vitamin C fizzy granule that allaying tiredness, men and women, old and young all take like a shot.
Vitamin C fizzy granule of the present invention is made up of following component and percentage by weight: vitamin C 1-2, citric acid 8-10; Sodium bicarbonate 6-10, Icing Sugar 70-90, also should add that lemon yellow is an amount of, saccharin sodium is an amount of, edible essence is an amount of.
More excellent proportioning is: vitamin C 1.4%, citric acid 9.9%, sodium bicarbonate 8.5%, Icing Sugar 80%, lemon yellow 0.002%, saccharin sodium are an amount of, and edible essence is an amount of.
Preparation method may further comprise the steps:
(1) acid material preparation: citric acid is worn into fine powder, in 50-60 ℃ of drying 5～6 hours, take by weighing vitamin C, citric acid mix homogeneously respectively by proportional quantity, add the lemon yellow alcoholic solution, mix homogeneously is granulated, and is in 50-60 ℃ of dry 2.5-3.5 hour, standby;
(2) alkali material preparation: take by weighing Icing Sugar, sodium bicarbonate mix homogeneously respectively by proportional quantity, add lemon yellow, saccharin sodium aqueous solution, and edible essence, it is even to be mixed to color and luster, granulates, in 60～70 ℃ of dry 4.5-5.5 hours, standby;
(3) acid, alkali material mix: get dried acid material, alkali material mix homogeneously, send survey content and moisture qualified.
Vitamin C fizzy granule of the present invention is soluble in water, gas is fragrant, and sweet and sour is produced a large amount of bubbles when being dissolved in water, do not heat during use and stir, instant-drink, absorb fast, mouthfeel is good, suitable for all ages.
The specific embodiment
Embodiment 1
Component weight: vitamin C 14g, citric acid 101.25g, lemon yellow 0.00225g, distilled water 1.0ml, 95% ethanol 1.25ml, sodium bicarbonate 86.5g, Icing Sugar 820.0g, saccharin sodium 1.1g, lemon yellow 0.018g, distilled water 15ml, edible essence 0.6ml.
Method for making:
(1) acid material preparation: citric acid is worn into fine powder, in 60 ℃ of dryings 5 hours,, take by weighing vitamin C, citric acid fine powder mix homogeneously respectively by proportional quantity, add the lemon yellow alcoholic solution, mix homogeneously is granulated, in 58 ℃ of dryings 3 hours, clear acid material 113g sent and surveys content and the qualified back of moisture is standby.
(2) alkali material preparation: take by weighing Icing Sugar, sodium bicarbonate mix homogeneously respectively by proportional quantity, add lemon yellow, saccharin sodium aqueous solution, and edible essence, it is even to be mixed to color and luster, granulates, in 65 ℃ of dryings 5 hours, clear alkali material 887g, send survey content and moisture qualified after, standby.
(3) acid, alkali material mix: get acid material 113g, alkali material 887g mix homogeneously, send survey content and moisture qualified after, pack (every bag contains vitamin C 200mg) with composite membrane by the 15g/ bag.
Embodiment 2
1. acid material preparation: get citric acid 303.8kg and wear into fine powder, 60 ℃ of dryings 5.5 hours are got vitamin C 4.2kg and citric acid mix homogeneously, add the smart solution of the ethanol that contains the 0.675g lemon yellow, mix homogeneously, and granulation, in 58 ℃ of dryings 3 hours, standby;
2. alkali material preparation: get Icing Sugar 246kg, sodium bicarbonate 26kg, mix homogeneously adds the aqueous solution that contains lemon yellow 5.4g, saccharin sodium 330g, and edible essence 180ml, and it is even to be mixed to color and luster, granulates, and is in 65 ℃ of dryings 5 hours, standby;
3. acid, alkali material mix: get above acid material, alkali material, mix homogeneously, send survey content and moisture content qualified after, pack by the 15g/ bag with composite membrane.
(character) this product is faint yellow granule, gas fragrance, and sweet and sour produces a large amount of bubbles when being dissolved in water, and pH value should be 4.5～5.5.
(discriminating) gets this product fine powder an amount of (being equivalent to vitamin C 0.2g approximately), adds water 10ml and makes the vitamin C dissolving, filters, and gets subsequent filtrate according to following method test.
1. get solution 5ml, add silver nitrate test solution 0.5ml, promptly generate black precipitate.
2. get solution 5ml, add 1～2 of sodium dichlorophenol indophenolate test solution, the color of test solution promptly disappears.
[assay] gets the content under the content uniformity item, mix homogeneously, precision takes by weighing in right amount (being equivalent to vitamin C 0.2g approximately), add the cold water 100ml and the spirit of vinegar 10ml that newly boiled and make dissolving, add starch indicator solution 1ml, use iodine titration solution (0.1mol/L) titration immediately, show blue and in 30 seconds, do not fade to solution.Every 1ml iodine titration solution (0.1mol/L) is equivalent to the C of 8.806mg
6H
8O
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Claims (3)
1. vitamin C fizzy granule is characterized in that being made up of following component and percentage by weight: vitamin C 1-2%, citric acid 8-10%, sodium bicarbonate 6-10%, Icing Sugar 70-90%, lemon yellow is an amount of, sweeting agent is an amount of, and edible essence is an amount of.
2. vitamin C fizzy granule according to claim 1, it is characterized in that more excellent component and percentage by weight are: vitamin C 1.4%, citric acid 9.9%, sodium bicarbonate 8.5%, Icing Sugar 80%, lemon yellow 0.002%, saccharin sodium 0.1%, edible essence 0.002%.
3. the preparation method of vitamin C fizzy granule according to claim 1 and 2 is characterized in that may further comprise the steps:
1. acid material preparation: citric acid is worn into fine powder,, take by weighing vitamin C, citric acid, mix homogeneously according to the above ratio respectively in 50-60 ℃ of drying 5～6 hours, add the lemon yellow alcoholic solution, mix homogeneously is granulated, under 50-60 ℃ of condition dry 2.5-3.5 hour, granulate, standby;
2. alkali material preparation: take by weighing Icing Sugar, sodium bicarbonate mix homogeneously in proportion respectively, add lemon yellow, saccharin sodium aqueous solution and edible essence, it is even to be mixed to color and luster, granulates, in 60～70 ℃ of dry 4.5-5.5 hours, standby;
3. the soda acid material mixes: get dried acid material, alkali material mix homogeneously, after censorship survey content and moisture are qualified, be packaged as finished product with composite membrane by every bag of 15g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02139806 CN1203850C (en) | 2002-12-06 | 2002-12-06 | Effervescent vitamin C granule and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 02139806 CN1203850C (en) | 2002-12-06 | 2002-12-06 | Effervescent vitamin C granule and its prepn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1506047A true CN1506047A (en) | 2004-06-23 |
| CN1203850C CN1203850C (en) | 2005-06-01 |
Family
ID=34231891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 02139806 Expired - Fee Related CN1203850C (en) | 2002-12-06 | 2002-12-06 | Effervescent vitamin C granule and its prepn |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1203850C (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327838C (en) * | 2004-07-08 | 2007-07-25 | 北京科信必成医药科技发展有限公司 | Vitamin C oral disintegration tablet and its preparing method |
| CN102824313A (en) * | 2012-09-18 | 2012-12-19 | 东北制药（沈阳）科技发展有限公司 | Vitamin C effervescent granule and preparation method thereof |
| CN107184579A (en) * | 2017-06-01 | 2017-09-22 | 防城港圣保堂制药有限公司 | A kind of ion VC granules and preparation method thereof |
-
2002
- 2002-12-06 CN CN 02139806 patent/CN1203850C/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1327838C (en) * | 2004-07-08 | 2007-07-25 | 北京科信必成医药科技发展有限公司 | Vitamin C oral disintegration tablet and its preparing method |
| CN102824313A (en) * | 2012-09-18 | 2012-12-19 | 东北制药（沈阳）科技发展有限公司 | Vitamin C effervescent granule and preparation method thereof |
| CN102824313B (en) * | 2012-09-18 | 2014-09-24 | 东北制药集团沈阳第一制药有限公司 | Vitamin C effervescent granule and preparation method thereof |
| CN107184579A (en) * | 2017-06-01 | 2017-09-22 | 防城港圣保堂制药有限公司 | A kind of ion VC granules and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1203850C (en) | 2005-06-01 |
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Owner name: CHANGSHA KANGERJIA PHARMACY GROUP CO.,LTD. Free format text: FORMER OWNER: CHANGSHA TAIBAO PHARMACEUTICAL CO., LTD. Effective date: 20100129 |
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Effective date of registration: 20100129 Address after: No. 198 west slope, Changsha, Hunan, Tongzi Patentee after: Changsha kaang'er Pharmaceutical Group Co., Ltd. Address before: No. 17 South Shaoshan Road, Hunan, Changsha Patentee before: Taibao Pharmaceutical Co., Ltd., Changsha |
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Owner name: HU NAN KANGERJIA PHARMACEUTICAL MANAGEMENT GROUP C Free format text: FORMER OWNER: CHANGSHA KANGERJIA PHARMACEUTICAL GROUP CO., LTD. Effective date: 20101119 |
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Effective date of registration: 20101119 Address after: 410205 No. 198 west slope road, Changsha, Hunan, Tongzi Patentee after: Hunan Kang Medicine Management Group Co., Ltd. Address before: 410205 No. 198 west slope road, Changsha, Hunan, Tongzi Patentee before: Changsha kaang'er Pharmaceutical Group Co., Ltd. |
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| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20050601 Termination date: 20121206 |