CN103655500A - Vitamin c tablet and preparation method thereof - Google Patents
Vitamin c tablet and preparation method thereof Download PDFInfo
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- CN103655500A CN103655500A CN201310717370.2A CN201310717370A CN103655500A CN 103655500 A CN103655500 A CN 103655500A CN 201310717370 A CN201310717370 A CN 201310717370A CN 103655500 A CN103655500 A CN 103655500A
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Abstract
The invention relates to a vitamin C tablet and a preparation method thereof. The vitamin C tablet is prepared with the following raw materials by weight: 100 parts of vitamin C, 36 parts of microcrystalline cellulose, 1.3 parts of antioxidant, 0.14 parts of magnesium stearate, and 23 parts of 7% starch slurry. Considered about that the vitamin C is easy to oxidize, decompose, and affect by heat, the novel microcapsule technology is adopted in the test process to encapsulate the vitamin C, and through meticulous research for many years, the poor stability problem of the vitamin C tablet is finally overcome.
Description
Technical field
The present invention relates to a kind of VITAMIN C TABLET and preparation method thereof, belong to field of medicaments.
Background technology
Vitamin C is again ascorbic acid, is a kind of necessary water soluble vitamins, and it is relevant with the multiple metabolism of human body.Human body can not synthesize and store, and must absorb from the external world.Vitamin C storage rate is in vivo relevant with intake, and dosage is less, and storage rate is higher in vivo, can from urine, not discharge completely.Vitamin C Deficiency of Intake, can cause body to occur various diseases.The ascorbic dosage form of domestic production mainly contains injection, granule, tablet, capsule etc. at present, because VC is unstable, heat and oxidizable decomposition in water liquid, so such keeping life is all shorter, the longest domestic shelf-life is 1 year at present, is dealt in client's hands after sometimes producing, product had just lost efficacy, according to this special chemical character, the stability of this product formulation is difficult to be guaranteed, and its preparation production process must strictly be controlled.
Summary of the invention
In order to overcome above-mentioned defect, the object of the present invention is to provide a kind of VITAMIN C TABLET and preparation method thereof.
To achieve these goals, the present invention adopts following technical scheme:
A VITAMIN C TABLET, it comprises that the raw material of following weight portion makes:
Vitamin C 100 microcrystalline Cellulose 36 antioxidant 1.3
Magnesium stearate 0.14 7% starch slurry 23.
A kind of method for preparing tablet thereof of VITAMIN C TABLET:
Antioxidant is dissolved in suitable water, then heating is rushed starch and is made 7% starch slurry;
Vitamin C was pulverized after 160 mesh sieves, standby;
Granulate: the vitamin C of above-mentioned weight portion, microcrystalline Cellulose are put in trough type mixing machine, mixed, add 7% starch slurry high-speed cutting to make soft material; put in oscillating granulator and granulate; pour in pallet and send in heat-circulation oven, control temperature 60-70 ℃, dry 40-60 minute; after particle drying, pour out granule; put in mixer, add magnesium stearate, mix 15 minutes; tabletting, packs and get final product.
A kind of capsule preparation method thereof of VITAMIN C TABLET:
Antioxidant is dissolved in to 50% in alcohol, standby; Vitamin C was pulverized after 160 mesh sieves, standby;
Granulate: above-mentioned weight portion vitamin C, microcrystalline Cellulose are put in trough type mixing machine; mix, add 50% alcohol high-speed cutting make soft material, put in oscillating granulator and granulate; pour in pallet and send in heat-circulation oven; control temperature 60-70 ℃, dry 40-60 minute pours out granule after particle drying; put in mixer; mix 15 minutes, fill, plastic-aluminum, pack and get final product.
Beneficial effect of the present invention:
The present invention examines filter to its oxidation Decomposition, the fearness feature such as be heated, and in process of the test, employs new technology again--and microcapsule technology wraps up vitamin C, studies intensively by time for many years, finally captures VITAMIN C TABLET poor stability difficulty.
The specific embodiment
Below in conjunction with embodiment, describe the present invention:
A VITAMIN C TABLET, it comprises that the raw material of following weight portion makes:
Vitamin C 100 microcrystalline Cellulose 36 antioxidant 1.3
Magnesium stearate 0.14 7% starch slurry 23.
A kind of method for preparing tablet thereof of VITAMIN C TABLET:
Antioxidant is dissolved in suitable water, then heating is rushed starch and is made 7% starch slurry;
Vitamin C was pulverized after 160 mesh sieves, standby;
Granulate: the vitamin C of above-mentioned weight portion, microcrystalline Cellulose are put in trough type mixing machine, mixed, add 7% starch slurry high-speed cutting to make soft material; put in oscillating granulator and granulate; pour in pallet and send in heat-circulation oven, control temperature 60-70 ℃, dry 40-60 minute; after particle drying, pour out granule; put in mixer, add magnesium stearate, mix 15 minutes; tabletting, packs and get final product.
A kind of capsule preparation method thereof of VITAMIN C TABLET:
Antioxidant is dissolved in to 50% in alcohol, standby; Vitamin C was pulverized after 160 mesh sieves, standby;
Granulate: above-mentioned weight portion vitamin C, microcrystalline Cellulose are put in trough type mixing machine; mix, add 50% alcohol high-speed cutting make soft material, put in oscillating granulator and granulate; pour in pallet and send in heat-circulation oven; control temperature 60-70 ℃, dry 40-60 minute pours out granule after particle drying; put in mixer; mix 15 minutes, fill, plastic-aluminum, pack and get final product.
adopt following detection method checking invention effect:
Precision takes appropriate this product, (being approximately equivalent to VC0.2 ɡ), to put in 100ml measuring bottle, the mixed liquor that adds the water purification 100ml that newly boiled and spirit of vinegar 10ml is appropriate, jolting is dissolved VC, and release to degree, shake up, filter, precision measures subsequent filtrate 50ml, add starch indicator solution 1ml, use immediately iodine titration solution (0.05 mol/L) titration, to the aobvious blue color of solution special continuous not taking off for 30 seconds.Every 1 ml iodine titration solution 0.05 mol/L is equivalent to 8.806mgC6H8O6
Test specimen, 37 ℃ of temperature, is carried out to stability and accelerates to investigate under 54 ℃ of conditions of relative humidity, probation divides half a year, and 1 year, 1.5 years and 2 years, and sampling detects respectively.
Testing result is as follows: sample specification is all 0.1m ɡ/sheet (grain), before the deadline content acceptability limit 0.093-0.107m ɡ
The result:
From above-mentioned result of the test, the stability of this product can reach 2 years, captured the poor difficulty of VC tablet stability, broken the current the longest domestic shelf-life and be the record of 1 year, absolutely prove: our company adopts, and VC is carried out to microcapsule technique for packing is feasible, and its technical merit reaches advanced international level.
Claims (3)
1. a VITAMIN C TABLET, is characterized in that: it comprises that the raw material of following weight portion makes:
Vitamin C 100 microcrystalline Cellulose 36 antioxidant 1.3
Magnesium stearate 0.14 7% starch slurry 23.
2. a method for preparing tablet thereof of preparing VITAMIN C TABLET described in claim 1, is characterized in that:
Antioxidant is dissolved in suitable water, then heating is rushed starch and is made 7% starch slurry;
Vitamin C was pulverized after 160 mesh sieves, standby;
Granulate: the vitamin C of above-mentioned weight portion, microcrystalline Cellulose are put in trough type mixing machine, mixed, add 7% starch slurry high-speed cutting to make soft material; put in oscillating granulator and granulate; pour in pallet and send in heat-circulation oven, control temperature 60-70 ℃, dry 40-60 minute; after particle drying, pour out granule; put in mixer, add magnesium stearate, mix 15 minutes; tabletting, packs and get final product.
3. a capsule preparation method thereof of preparing VITAMIN C TABLET described in claim 1, is characterized in that:
Antioxidant is dissolved in to 50% in alcohol, standby; Vitamin C was pulverized after 160 mesh sieves, standby;
Granulate: above-mentioned weight portion vitamin C, microcrystalline Cellulose are put in trough type mixing machine; mix, add 50% alcohol high-speed cutting make soft material, put in oscillating granulator and granulate; pour in pallet and send in heat-circulation oven; control temperature 60-70 ℃, dry 40-60 minute pours out granule after particle drying; put in mixer; mix 15 minutes, fill, plastic-aluminum, pack and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310717370.2A CN103655500B (en) | 2013-12-24 | 2013-12-24 | A kind of VITAMIN C TABLET and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201310717370.2A CN103655500B (en) | 2013-12-24 | 2013-12-24 | A kind of VITAMIN C TABLET and preparation method thereof |
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| CN103655500A true CN103655500A (en) | 2014-03-26 |
| CN103655500B CN103655500B (en) | 2015-09-09 |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104490829A (en) * | 2014-12-05 | 2015-04-08 | 海南卫康制药(潜山)有限公司 | Vitamin C composition freeze-dried tablets and preparation method thereof |
| CN105851768A (en) * | 2016-03-31 | 2016-08-17 | 常州大学 | Preparation method of natural and easily edible vitamin C tablets without adding of accessory materials |
| CN110169966A (en) * | 2019-06-25 | 2019-08-27 | 上海长征医院 | Vitamin C inhibits the purposes in human mouth squamous carcinoma product in preparation |
| CN110420189A (en) * | 2019-08-27 | 2019-11-08 | 新乡市常乐制药有限责任公司 | A kind of control method that vitamin C tablet is anti-oxidation |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897673A (en) * | 2009-05-27 | 2010-12-01 | 华北制药集团制剂有限公司 | Method for preparing vitamin C tablet |
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2013
- 2013-12-24 CN CN201310717370.2A patent/CN103655500B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101897673A (en) * | 2009-05-27 | 2010-12-01 | 华北制药集团制剂有限公司 | Method for preparing vitamin C tablet |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104490829A (en) * | 2014-12-05 | 2015-04-08 | 海南卫康制药(潜山)有限公司 | Vitamin C composition freeze-dried tablets and preparation method thereof |
| CN105851768A (en) * | 2016-03-31 | 2016-08-17 | 常州大学 | Preparation method of natural and easily edible vitamin C tablets without adding of accessory materials |
| CN110169966A (en) * | 2019-06-25 | 2019-08-27 | 上海长征医院 | Vitamin C inhibits the purposes in human mouth squamous carcinoma product in preparation |
| CN110420189A (en) * | 2019-08-27 | 2019-11-08 | 新乡市常乐制药有限责任公司 | A kind of control method that vitamin C tablet is anti-oxidation |
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| CN103655500B (en) | 2015-09-09 |
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