CN102824313B - Vitamin C effervescent granule and preparation method thereof - Google Patents
Vitamin C effervescent granule and preparation method thereof Download PDFInfo
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- CN102824313B CN102824313B CN201210347555.4A CN201210347555A CN102824313B CN 102824313 B CN102824313 B CN 102824313B CN 201210347555 A CN201210347555 A CN 201210347555A CN 102824313 B CN102824313 B CN 102824313B
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Abstract
The invention discloses a vitamin C effervescent granule and a preparation method thereof applied to the field of preparations of vitamin C. The vitamin C effervescent granule comprises acid granules and alkali granules; the acid granules mainly comprise vitamin C and effervescent agent acid sources; the alkali granules mainly comprise effervescent agent alkali sources; the effervescent agent acid sources are effervescent agent acid sources crystals; or the effervescent agent acid sources are the effervescent agent acid source crystals and the vitamin C which is a vitamin C crystal. The preparation method comprises the steps of respectively preparing the acid granules and the alkali granules; and packaging the acid granules and the alkali granules according to the proportion of a prescription to obtain the VC effervescent granule. According to the vitamin C effervescent granule and the preparation method thereof disclosed by the invention, the acid granules are prepared from the effervescent agent acid source crystals and the vitamin C crystal, so that the disintegration speed of the vitamin C effervescent granule is improved and the effervescent granule can be quickly disintegrated at a lower water temperature; and meanwhile, the stability of the vitamin C effervescent granule is improved by adopting accessories with small hygroscopicity, and thus the storage and the transportation of the vitamin C are facilitated.
Description
Technical field
The present invention relates to a kind of vitamin C fizzy granule in ascorbic formulation art and preparation method thereof.
Background technology
Vitamin C is to maintain the necessary material of the normal life process of body, participates in vivo multiple reaction, has the multiple effects such as synthetic, treatment vitamin C deficiency, prevention of arterial sclerosis that promote collagen protein.Current ascorbic dosage form mainly contains injection, pill, conventional tablet, effervescent tablet, plain particles agent and effervescent granule etc., effervescent vitamin C granule wherein, a kind of novel dosage form as Abroad in Recent Years Application and Development, due to have disintegrate fast, taking convenience, absorption is very fast, bioavailability is high, onset is rapid, carry, preserve, transport all features such as more convenient, more and more be subject to liking of patient, be specially adapted to child, old people and the patient of pill difficulty that swallows.But at the bottom of current effervescent vitamin C granule often exists in water and disperses, often sinks to glass, the overtime problem of disintegrate, and disintegration time is subject to Water Temperature, when water temperature is lower, often disintegrate time used is longer.In addition, because the surface area of vitamin C granules agent is larger, so often there is the problem of the easy moisture absorption, poor stability.Therefore, develop a kind of vitamin C fizzy granule and preparation method thereof is new problem urgently to be resolved hurrily always.
Summary of the invention
The object of the present invention is to provide a kind of disintegrate fast, still disintegrate fast under lower water temperature, be difficult for the moisture absorption, the better vitamin C fizzy granule of stability and preparation method thereof.
The object of the present invention is achieved like this: a kind of vitamin C fizzy granule, comprise acid grain and alkali grain, described acid grain is mainly comprised of vitamin C and effervescent acid source, and described alkali grain is mainly comprised of effervescent alkali source, and described effervescent acid source is effervescent acid source crystal; Described acid grain is mainly comprised of vitamin C and effervescent acid source, and described alkali grain is mainly comprised of effervescent alkali source, and described effervescent acid source is that effervescent acid source crystal and described vitamin C are vitamin C crystal; Described effervescent acid source crystal is 30-70 order crystal, preferably 40-60 order crystal; Described vitamin C crystal is 30-70 order crystal, preferably 40-60 order crystal; Described effervescent acid source is selected from one or more in tartaric acid, citric acid, malic acid; Described effervescent alkali source is selected from one or more in sodium bicarbonate, sodium carbonate, potassium bicarbonate, calcium carbonate; In described vitamin C fizzy granule, also comprise other adjuvant, the weight percent content of each composition in described vitamin C fizzy granule is respectively, described vitamin C is that 5%-15%, described effervescent acid source are that 30%-45%, described effervescent alkali source are 35%-45%, and other described adjuvant is 6%-21%; Other described adjuvant comprises filler, correctives, pigment and binding agent; Described filler is selected from one or both in sucrose, lactose; Described correctives is selected from one or more in aspartame, cyclamate, sodium chloride; Described pigment is selected from one or more in VB2, sunset yellow, lemon yellow, beta-carotene; Described binding agent is selected from one or more in hydroxypropyl emthylcellulose, polyvinylpyrrolidone, syrup; The percentage by weight that each composition in described other adjuvant accounts for described vitamin C fizzy granule is respectively, described filler 3.4%-19.6%, described correctives 1.0%-2.8%, described pigment 0.33-0.38% and described binding agent 0.17%-0.26%; This preparation method comprises the steps:
(1) pigment in described acid grain is dissolved in ethanol water, obtains the ethanol water that contains pigment, described vitamin C and effervescent acid source are pressed after recipe quantity mix homogeneously, with the above-mentioned ethanol water that contains pigment, prepare soft material, granulate, dry, screening, obtains described acid grain;
(2) pigment in described alkali grain is dissolved in binder aqueous solution, obtain the binder aqueous solution that contains pigment, described effervescent alkali source, filler and correctives are pressed after recipe quantity mix homogeneously, with the above-mentioned binder aqueous solution that contains pigment, prepare soft material, granulate, dry, screening, obtains described alkali grain;
(3) VC effervescent granule is packed and obtained to described acid grain with alkali grain in prescription ratio;
The concentration of described ethanol water is 70%-90%, and preferred concentration is 80%; The described ultrasonic dissolution that is dissolved as; Described granulation is by 20-30 mesh sieve, preferably by 24 mesh sieves; The temperature of described oven dry is 40-60 ℃, and preferably temperature is 50 ℃; Described screening be sieve to obtain particle diameter be the granule between 10-20 mesh sieve and 50-70 mesh sieve, being preferably sieve, to obtain particle diameter be the granule between 16 mesh sieves and 60 mesh sieves;
Main points of the present invention are vitamin C fizzy granular recipe and preparation method.Its principle is: by adopting effervescent acid source crystal preparation acid grain, or by adopting effervescent acid source crystal and vitamin C crystal preparation acid grain, utilize the anisotropy of crystal, improved greatly disintegration rate, the especially effervescent granule still disintegrate fast under lower water temperature of vitamin C fizzy granule.Meanwhile, the present invention draws moist little adjuvant by employing, has improved greatly the stability of vitamin C fizzy granule, for convenience of vitamin C storage and transportation, lays a good foundation.
A kind of vitamin C fizzy granule and preparation method thereof compared with prior art, by adopting effervescent acid source crystal preparation acid grain, or by adopting effervescent acid source crystal and vitamin C crystal preparation acid grain, improved greatly the disintegration rate of vitamin C fizzy granule, especially effervescent granule still disintegrate fast under lower water temperature, by employing, draw moist little adjuvant, improved greatly the stability of vitamin C fizzy granule, for convenience of advantages such as vitamin C storage and transportations, will be widely used in ascorbic formulation art.
Below in conjunction with embodiment, the present invention is described in detail.
The specific embodiment
Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Embodiment mono-
Acid grain formula:
Vitamin C (40 order-60 order crystal) 150g; Tartaric acid (40 order-60 order crystal) 1050g; Sunset yellow 1g.
Alkali grain formula:
Sodium bicarbonate 1200g; Sodium chloride 30g; Sucrose 400g; Aspartame 50g; Sunset yellow 10g; Hydroxypropyl emthylcellulose 5g.
Preparation technology: acid grain: recipe quantity sunset yellow is dissolved in appropriate 80% ethanol water by ultrasonic, obtains the ethanol water that contains pigment.Vitamin C, tartaric acid are pressed after recipe quantity mix homogeneously, with the ethanol water that contains pigment preparing, prepared soft material, carry out 24 mesh sieve granulations, 50 ℃ of oven dry, sieve by 16 mesh sieves and 60 mesh sieves respectively.
Alkali grain: sunset yellow is dissolved in 5% (w/w) hydroxypropyl emthylcellulose (50cp), obtains the binder aqueous solution that contains pigment.Sodium bicarbonate, sodium chloride and sucrose are pressed after recipe quantity mix homogeneously, with the binder aqueous solution that contains pigment preparing, prepared soft material, carry out 24 mesh sieve granulations, 50 ℃ of oven dry, sieve by 16 mesh sieves and 60 mesh sieves respectively.
Vitamin C fizzy granule is packed and obtained to above-mentioned acid grain with alkali grain in prescription ratio.
Embodiment bis-
Acid grain formula:
Vitamin C (40 order-60 order) 450g; Citric acid (40 order-60 order) 910g; Sunset yellow 2g.
Alkali grain formula:
Sodium carbonate 1060g; Sodium chloride 6g; Sucrose 600g; Aspartame 25g; Sunset yellow 8g; Polyvinylpyrrolidone 8g.
Preparation technology: acid grain: recipe quantity sunset yellow is dissolved in appropriate 80% ethanol water by ultrasonic, obtains the ethanol water that contains pigment.Vitamin C, citric acid are pressed after recipe quantity mix homogeneously, with the ethanol water that contains pigment preparing, prepared soft material, carry out 24 mesh sieve granulations, 50 ℃ of oven dry, sieve by 16 mesh sieves and 60 mesh sieves respectively.
Alkali grain: sunset yellow is dissolved in 12% (w/w) polyvinylpyrrolidone aqueous solution, obtains the binder aqueous solution that contains pigment.Sodium carbonate, sodium chloride, sucrose and aspartame are pressed after recipe quantity mix homogeneously, with the binder aqueous solution that contains pigment preparing, prepared soft material, carry out 24 mesh sieve granulations, 50 ℃ of oven dry, sieve by 16 mesh sieves and 60 mesh sieves respectively.
Vitamin C fizzy granule is packed and obtained to above-mentioned acid grain with alkali grain in prescription ratio.
Embodiment tri-
Acid grain formula:
Vitamin C (40 order-60 order) 200g; Malic acid (40 order-60 order) 1200g; Lemon yellow 1.5g.
Alkali grain formula:
Sodium bicarbonate 1320g; Sodium chloride 10g; Sucrose 100g; Aspartame 60g; Lemon yellow 8.5g; Syrup 6g.
Preparation technology: acid grain: recipe quantity lemon yellow is dissolved in appropriate 70% ethanol water by ultrasonic, obtains the ethanol water that contains pigment.Vitamin C, malic acid are pressed after recipe quantity mix homogeneously, with the ethanol water that contains pigment preparing, prepared soft material, carry out 20 mesh sieve granulations, 40 ℃ of oven dry, sieve by 16 mesh sieves and 60 mesh sieves respectively.
Alkali grain: lemon yellow is dissolved in 10% syrup aqueous solution, obtains the binder aqueous solution that contains pigment.Sodium bicarbonate, sodium chloride, sucrose and aspartame are pressed after recipe quantity mix homogeneously, with the binder aqueous solution that obtains containing pigment preparing, prepared soft material, carry out 20 mesh sieve granulations, 40 ℃ of oven dry, sieve by 16 mesh sieves and 60 mesh sieves respectively.
Vitamin C fizzy granule is packed and obtained to above-mentioned acid grain with alkali grain in prescription ratio.
Embodiment tetra-
Acid grain formula:
Vitamin C (30 order-50 order crystal) 150g; Tartaric acid (30 order-50 order crystal) 1050g; VB
21g.
Alkali grain formula:
Potassium bicarbonate 1200g; Sodium chloride 30g; Sucrose 530g; VB
210g; Hydroxypropyl emthylcellulose 5g.
Preparation technology: acid grain: by recipe quantity VB
2by ultrasonic, be dissolved in appropriate 80% ethanol water, obtain the ethanol water that contains pigment.Vitamin C, tartaric acid are pressed after recipe quantity mix homogeneously, with the ethanol water that contains pigment preparing, prepared soft material, carry out 24 mesh sieve granulations, 50 ℃ of oven dry, sieve by 20 mesh sieves and 70 mesh sieves respectively.
Alkali grain: by VB
2be dissolved in 6% (w/w) hydroxypropyl emthylcellulose (50cp), obtain the binder aqueous solution that contains pigment.Potassium bicarbonate, sodium chloride and sucrose are pressed after recipe quantity mix homogeneously, with the binder aqueous solution that contains pigment preparing, prepared soft material, carry out 30 mesh sieve granulations, 50 ℃ of oven dry, sieve by 20 mesh sieves and 70 mesh sieves respectively.
Vitamin C fizzy granule is packed and obtained to above-mentioned acid grain with alkali grain in prescription ratio.
Embodiment five
Acid grain formula:
Vitamin C (50 order-70 order crystal) 150g; Tartaric acid (50 order-70 order crystal) 1300g; Beta-carotene 1g.
Alkali grain formula:
Calcium carbonate 1200g; Lactose 200g; Cyclamate 50g; Beta-carotene 10g; Hydroxypropyl emthylcellulose 5g.
Preparation technology: acid grain: recipe quantity beta-carotene is dissolved in appropriate 90% ethanol water by ultrasonic, obtains the ethanol water that contains pigment.Vitamin C, tartaric acid are pressed after recipe quantity mix homogeneously, with the ethanol water that contains pigment preparing, prepared soft material, carry out 30 mesh sieve granulations, 60 ℃ of oven dry, sieve by 10 mesh sieves and 50 mesh sieves respectively.
Alkali grain: beta-carotene is dissolved in 8% (w/w) hydroxypropyl emthylcellulose (50cp) aqueous solution, obtains the binder aqueous solution that contains pigment.Calcium carbonate, cyclamate and lactose are pressed after recipe quantity mix homogeneously, with the binder aqueous solution that contains pigment preparing, prepared soft material, carry out 30 mesh sieve granulations, 60 ℃ of oven dry, sieve by 10 mesh sieves and 50 mesh sieves respectively.
Vitamin C fizzy granule is packed and obtained to above-mentioned acid grain with alkali grain in prescription ratio.
Embodiment six
Acid grain formula:
Vitamin C (40 order-60 order crystal) 300g; Tartaric acid (40 order-60 order crystal) 600g; Citric acid (40 order-60 order crystal) 600g; Beta-carotene 1g.
Alkali grain formula:
Sodium bicarbonate 600g; Potassium bicarbonate 600g; Sucrose 180g; Aspartame 60g; Beta-carotene 10g; Hydroxypropyl emthylcellulose 5g.
Preparation technology: acid grain: recipe quantity beta-carotene is dissolved in appropriate 80% ethanol water by ultrasonic, obtains the ethanol water that contains pigment.Vitamin C, tartaric acid, citric acid are pressed after recipe quantity mix homogeneously, with the ethanol water that contains pigment preparing, prepared soft material, carry out 24 mesh sieve granulations, 50 ℃ of oven dry, sieve by 16 mesh sieves and 60 mesh sieves respectively.
Alkali grain: beta-carotene is dissolved in 6% (w/w) hydroxypropyl emthylcellulose (50cp) aqueous solution, obtains the binder aqueous solution that contains pigment.Sodium bicarbonate, potassium bicarbonate, aspartame and sucrose are pressed after recipe quantity mix homogeneously, with the binder aqueous solution that contains pigment preparing, prepared soft material, carry out 24 mesh sieve granulations, 50 ℃ of oven dry, sieve by 16 mesh sieves and 60 mesh sieves respectively.
VC effervescent granule is packed and obtained to above-mentioned acid grain with alkali grain in prescription ratio.
The acid grain being made by above-described embodiment one to embodiment six and alkali grain can, according to packing after the prescription ratio mix homogeneously of each embodiment, also can separate independent packaging by acid grain and alkali grain according to the prescription ratio of each embodiment.
The prescription of employing embodiment mono-and VC effervescent granule study on the stability result prepared by method are as follows:
By this product in commercially available back (adopting the manner of packing of packing after evenly mixing according to prescription ratio), under the condition that to be placed in respectively temperature and to be 40 ℃ ± 2 ℃, relative humidity be 75% ± 5% and temperature be under 30 ℃ ± 2 ℃, the relative humidity condition that is 65% ± 5%, in incubator, place 3 months, in 1,2,3 the end of month sampling and measuring, and with sample comparison in 0 month.Accelerate experimental result and the results are shown in Table 1 disintegration.The assay method of disintegration, for getting 6 bags of this product, adds respectively the water 100ml of 5 ℃, records disintegration time, and unit is second.
Table 1 vitamin C fizzy granular mass check result and accelerated test result
Result shows, vitamin C fizzy granule of the present invention is after carrying out accelerated test, quality and having good stability, accelerate 1 month, 2 months and after 3 months, under the lower water temperature of 5 ℃, still can produce shorter effect disintegration, and the character of effervescent granule is stable, there is not swollen bag and caking phenomenon, the higher and stable content of Vitamin C content.
For checking adopts effervescent acid source crystal preparation acid grain, or adopt effervescent acid source crystal and vitamin C crystal preparation acid grain can significantly improve disintegration rate, do respectively following contrast test and investigate relatively:
Vitamin C fizzy granule is as follows about 2010 editions standards of Chinese Pharmacopoeia of disintegration: gets 6 bags of this product, adds respectively the water 100ml of 15 ℃, and should disintegrate in 5 minutes.
Contrast test 1: according to above-mentioned six embodiment prescription, the vitamin C fizzy granule that is made vitamin C and acid source into powder preparation by crystal with the vitamin C fizzy granule time limit comparing result of preparing according to above-mentioned six example formulation and technologies in Table 2.The assay method of disintegration, for getting 6 bags of this product, adds respectively the water 100ml of 5 ℃, records disintegration time, and unit is second.
VC and the impact of acid source state on disintegration during the different acid source kind of table 2
| Vitamin C and acid source state | Example sequence number | Disintegration (unit: second, 5 ℃ of water temperatures) |
| Crystal | Embodiment 1 | 100 |
| Crystal | Embodiment 2 | 126 |
| Crystal | Embodiment 3 | 132 |
| Crystal | Embodiment 4 | 106 |
| Crystal | Embodiment 5 | 103 |
| Crystal | Embodiment 6 | 116 |
| Powder | Embodiment 1 | >300 |
| Powder | Embodiment 2 | >300 |
| Powder | Embodiment 3 | >300 |
| Powder | Embodiment 4 | >300 |
| Powder | Embodiment 5 | >300 |
| Powder | Embodiment 6 | >300 |
Experimental result shows, adopts vitamin C crystal and acid source crystal to prepare the disintegration that vitamin C fizzy granule can significantly shorten effervescent granule.
Contrast test 2: according to the prescription of embodiment mono-and preparation technology, vitamin C and tartaric state are investigated, under different water temperatures, its impact on disintegration the results are shown in Table 3.The assay method of disintegration is for getting 6 bags of this product, adds respectively the water 100ml of 5 ℃ or 10 ℃ or 15 ℃, records disintegration time, and unit is second.
VC and the impact of tartaric acid state on disintegration rate under the different water temperatures of table 3
The powder that powder in above-mentioned contrast test 1 and contrast test 2 obtains after referring to vitamin C crystal or tartaric acid crystal being pulverized.If vitamin C or tartaric acid are powder, after need adding a certain amount of filler to mix in the acid grain formula of corresponding embodiment, granulate, carry out investigation disintegration, be specially in the acid grain prescription of embodiment mono-, embodiment bis-, embodiment tri-, embodiment tetra-, embodiment six and add respectively sucrose 160g, in the acid grain prescription of embodiment five, add lactose 160g.
Experimental result shows, adopts vitamin C fizzy granule prepared by tartaric acid crystal or the vitamin C fizzy granule that adopts vitamin C crystal and tartaric acid crystal to prepare at lower temperature, still can produce the effect of disintegration of remarkable shortening vitamin C fizzy granule.
Claims (13)
1. a vitamin C fizzy granule, comprise acid grain and alkali grain, it is characterized in that: described acid grain is mainly comprised of vitamin C and effervescent acid source, described alkali grain is mainly comprised of effervescent alkali source, described effervescent acid source is effervescent acid source crystal, in described vitamin C fizzy granule, also comprise other adjuvant, the weight percent content of each composition in described vitamin C fizzy granule is respectively, described vitamin C is that 5%-15%, described effervescent acid source are that 30%-45%, described effervescent alkali source are 35%-45%, and other described adjuvant is 6%-21%.
2. a vitamin C fizzy granule, comprise acid grain and alkali grain, it is characterized in that: described acid grain is mainly comprised of vitamin C and effervescent acid source, and described alkali grain is mainly comprised of effervescent alkali source, and described effervescent acid source is that effervescent acid source crystal and described vitamin C are vitamin C crystal.
3. a kind of vitamin C fizzy granule according to claim 2, is characterized in that: described effervescent acid source crystal is 30-70 order crystal; Described vitamin C crystal is 30-70 order crystal.
4. a kind of vitamin C fizzy granule according to claim 3, is characterized in that: described effervescent acid source crystal is 40-60 order crystal; Described vitamin C crystal is 40-60 order crystal.
5. a kind of vitamin C fizzy granule according to claim 1 and 2, is characterized in that: described effervescent acid source is selected from one or more in tartaric acid, citric acid, malic acid; Described effervescent alkali source is selected from one or more in sodium bicarbonate, sodium carbonate, potassium bicarbonate, calcium carbonate.
6. a kind of vitamin C fizzy granule according to claim 2, it is characterized in that: in described vitamin C fizzy granule, also comprise other adjuvant, the weight percent content of each composition in described vitamin C fizzy granule is respectively, described vitamin C is that 5%-15%, described effervescent acid source are that 30%-45%, described effervescent alkali source are 35%-45%, and other described adjuvant is 6%-21%.
7. a kind of vitamin C fizzy granule according to claim 1, is characterized in that: other described adjuvant comprises filler, correctives, pigment and binding agent.
8. a kind of vitamin C fizzy granule according to claim 6, is characterized in that: other described adjuvant comprises filler, correctives, pigment and binding agent.
9. according to a kind of vitamin C fizzy granule described in claim 7 or 8, it is characterized in that: described filler is selected from one or both in sucrose, lactose; Described correctives is selected from one or more in aspartame, cyclamate, sodium chloride; Described pigment is selected from one or more in VB2, sunset yellow, lemon yellow, beta-carotene; Described binding agent is selected from one or more in hydroxypropyl emthylcellulose, polyvinylpyrrolidone, syrup.
10. according to a kind of vitamin C fizzy granule described in claim 7 or 8, it is characterized in that: the percentage by weight that each composition in described other adjuvant accounts for described vitamin C fizzy granule is respectively described filler 3.4%-19.6%, described correctives 1.0%-2.8%, described pigment 0.33-0.38% and described binding agent 0.17%-0.26%.
11. according to the preparation method of a kind of vitamin C fizzy granule described in claim 7 or 8, it is characterized in that: this preparation method is comprised of following steps:
(1) pigment in described acid grain is dissolved in ethanol water, obtains the ethanol water that contains pigment, described vitamin C and effervescent acid source are pressed after recipe quantity mix homogeneously, with the above-mentioned ethanol water that contains pigment, prepare soft material, granulate, dry, screening, obtains described acid grain;
(2) pigment in described alkali grain is dissolved in binder aqueous solution, obtain the binder aqueous solution that contains pigment, described effervescent alkali source, filler and correctives are pressed after recipe quantity mix homogeneously, with the above-mentioned binder aqueous solution that contains pigment, prepare soft material, granulate, dry, screening, obtains described alkali grain;
(3) VC effervescent granule is packed and obtained to described acid grain with alkali grain in prescription ratio.
The preparation method of 12. a kind of vitamin C fizzy granules according to claim 11, is characterized in that: the concentration of described ethanol water is 70%-90%; The described ultrasonic dissolution that is dissolved as; Described granulation is by 20-30 mesh sieve; The temperature of described oven dry is 40-60 ℃; Described screening is that to obtain particle diameter be the granule between 10-20 mesh sieve and 50-70 mesh sieve to sieve.
The preparation method of 13. a kind of vitamin C fizzy granules according to claim 12, is characterized in that: the concentration of described ethanol water is 80%; Described granulation is by 24 mesh sieves; The temperature of described oven dry is 50 ℃; Described screening is that to obtain particle diameter be the granule between 16 mesh sieves and 60 mesh sieves to sieve.
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| CN105876363A (en) * | 2014-12-03 | 2016-08-24 | 仲恺农业工程学院 | Preparation method of compound fruit-vegetable-powder effervescent chewing tablets |
| CN106420655A (en) * | 2016-10-24 | 2017-02-22 | 广西圣保堂健康产业股份有限公司 | Effervescent tablet containing vitamin C sodium and preparation method of effervescent tablet |
| CN107137373B (en) * | 2017-05-23 | 2020-03-13 | 西北师范大学 | Tea polyphenol effervescent tablet and preparation method thereof |
| CN108967806A (en) * | 2017-05-31 | 2018-12-11 | 江苏汉典生物科技股份有限公司 | Vitamin c effervescent tablet and preparation method thereof |
| CN107184579A (en) * | 2017-06-01 | 2017-09-22 | 防城港圣保堂制药有限公司 | A kind of ion VC granules and preparation method thereof |
| CN112121017A (en) * | 2020-08-24 | 2020-12-25 | 南京海纳医药科技股份有限公司 | Compound effervescent granule containing acetaminophen/vitamin C and preparation method thereof |
| CN114041549B (en) * | 2021-11-29 | 2024-02-20 | 青岛博恩高科生物技术有限公司 | Preparation method of electrolyte effervescent powder and electrolyte effervescent powder |
| CN117441898B (en) * | 2023-12-22 | 2024-04-12 | 山东天力药业有限公司 | Vitamin C effervescent granule and preparation method thereof |
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