CN117441898B - Vitamin C effervescent granule and preparation method thereof - Google Patents
Vitamin C effervescent granule and preparation method thereof Download PDFInfo
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- CN117441898B CN117441898B CN202311774199.9A CN202311774199A CN117441898B CN 117441898 B CN117441898 B CN 117441898B CN 202311774199 A CN202311774199 A CN 202311774199A CN 117441898 B CN117441898 B CN 117441898B
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 title claims abstract description 172
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 title claims abstract description 85
- 229930003268 Vitamin C Natural products 0.000 title claims abstract description 85
- 239000011718 vitamin C Substances 0.000 title claims abstract description 85
- 235000019154 vitamin C Nutrition 0.000 title claims abstract description 85
- 239000008187 granular material Substances 0.000 title claims abstract description 60
- 238000002360 preparation method Methods 0.000 title claims abstract description 43
- 238000000498 ball milling Methods 0.000 claims abstract description 68
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 38
- 239000003381 stabilizer Substances 0.000 claims abstract description 37
- 238000002156 mixing Methods 0.000 claims abstract description 32
- 239000000843 powder Substances 0.000 claims abstract description 16
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims abstract description 11
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 11
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 11
- 239000000811 xylitol Substances 0.000 claims abstract description 11
- 235000010447 xylitol Nutrition 0.000 claims abstract description 11
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 11
- 229960002675 xylitol Drugs 0.000 claims abstract description 11
- 229940083466 soybean lecithin Drugs 0.000 claims abstract description 7
- 238000005469 granulation Methods 0.000 claims abstract description 6
- 230000003179 granulation Effects 0.000 claims abstract description 6
- 239000012299 nitrogen atmosphere Substances 0.000 claims abstract description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 30
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 235000005979 Citrus limon Nutrition 0.000 claims description 15
- 244000131522 Citrus pyriformis Species 0.000 claims description 15
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 15
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 15
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 15
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 15
- 239000002245 particle Substances 0.000 claims description 15
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 10
- 108010011485 Aspartame Proteins 0.000 claims description 10
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 10
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 10
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 10
- IMQLKJBTEOYOSI-GPIVLXJGSA-N Inositol-hexakisphosphate Chemical compound OP(O)(=O)O[C@H]1[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@@H]1OP(O)(O)=O IMQLKJBTEOYOSI-GPIVLXJGSA-N 0.000 claims description 10
- 229930195725 Mannitol Natural products 0.000 claims description 10
- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 claims description 10
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 10
- 239000004376 Sucralose Substances 0.000 claims description 10
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 10
- 239000000605 aspartame Substances 0.000 claims description 10
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 10
- 235000010357 aspartame Nutrition 0.000 claims description 10
- 229960003438 aspartame Drugs 0.000 claims description 10
- 239000008367 deionised water Substances 0.000 claims description 10
- 229910021641 deionized water Inorganic materials 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 10
- 125000005456 glyceride group Chemical group 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 10
- 235000010355 mannitol Nutrition 0.000 claims description 10
- 239000000594 mannitol Substances 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 10
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 10
- 239000000467 phytic acid Substances 0.000 claims description 10
- 235000002949 phytic acid Nutrition 0.000 claims description 10
- 229940068041 phytic acid Drugs 0.000 claims description 10
- 239000000661 sodium alginate Substances 0.000 claims description 10
- 235000010413 sodium alginate Nutrition 0.000 claims description 10
- 229940005550 sodium alginate Drugs 0.000 claims description 10
- 239000000600 sorbitol Substances 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 10
- 235000019408 sucralose Nutrition 0.000 claims description 10
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 10
- 239000011975 tartaric acid Substances 0.000 claims description 10
- 235000002906 tartaric acid Nutrition 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 6
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 5
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 5
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 5
- 229910052757 nitrogen Inorganic materials 0.000 claims description 5
- 238000005086 pumping Methods 0.000 claims description 5
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 5
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 5
- 235000010489 acacia gum Nutrition 0.000 claims description 4
- 239000001785 acacia senegal l. willd gum Substances 0.000 claims description 3
- 229920000084 Gum arabic Polymers 0.000 claims 1
- 239000000205 acacia gum Substances 0.000 claims 1
- 230000001276 controlling effect Effects 0.000 description 16
- 239000000243 solution Substances 0.000 description 13
- 241000220479 Acacia Species 0.000 description 6
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 5
- 238000004806 packaging method and process Methods 0.000 description 4
- 239000008347 soybean phospholipid Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000006187 pill Substances 0.000 description 2
- 239000002211 L-ascorbic acid Substances 0.000 description 1
- 235000000069 L-ascorbic acid Nutrition 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 206010047623 Vitamin C deficiency Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 208000019622 heart disease Diseases 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000006241 metabolic reaction Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 208000010233 scurvy Diseases 0.000 description 1
- 239000006076 specific stabilizer Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009747 swallowing Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/385—Concentrates of non-alcoholic beverages
- A23L2/39—Dry compositions
- A23L2/395—Dry compositions in a particular shape or form
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/40—Effervescence-generating compositions
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides vitamin C effervescent granules and a preparation method thereof, belonging to the technical field of vitamin C effervescent granules; the preparation method comprises the steps of vitamin C pretreatment, stabilizer preparation, auxiliary agent preparation and granulation; the vitamin C pretreatment step comprises the steps of placing vitamin C powder in nitrogen atmosphere for plasma ball milling treatment, wherein the ball milling time is 24-26min, the discharge voltage is 6-10kV, the discharge current is 66-70mA, the discharge frequency is 26-28kHz, adding soybean lecithin and xylitol after the plasma ball milling treatment is finished, mixing uniformly, and standing at 0.3-0.5 ℃ for 38-42min to obtain pretreated vitamin C. The vitamin C effervescent granule prepared by the invention has short disintegration time at low temperature, and can still keep short disintegration time after being placed for a long time.
Description
Technical Field
The invention belongs to the technical field of vitamin C effervescent granules, and in particular relates to a vitamin C effervescent granule and a preparation method thereof.
Background
Vitamin C, also called L-ascorbic acid, is a water-soluble vitamin, is abundant in fruits and vegetables, plays a regulating role in redox metabolic reactions, and the lack of vitamin C can cause scurvy, is a substance necessary for maintaining the normal life process of an organism, participates in various reactions in vivo, and has various effects of preventing cancers, heart diseases, stroke, protecting gums, teeth and the like.
At present, the vitamin C mainly comprises injection, pill, common tablet, effervescent tablet, common granule, effervescent granule and other dosage forms;
the vitamin C effervescent granule has the advantages of rapid disintegration, convenient administration, quick absorption, convenient carrying and the like, and is particularly suitable for the elderly, children and patients with difficult pill swallowing;
however, the disintegration time limit of the vitamin C effervescent granule prepared by the prior art is easily influenced by water temperature, the disintegration time limit is longer when the temperature is lower, and the disintegration time limit of the vitamin C is obviously prolonged after the vitamin C effervescent granule is placed for a long time, so that the service performance of a patient is seriously influenced.
Therefore, the vitamin C effervescent granule and the preparation method thereof are provided, the disintegration time limit at low temperature is short, and the short disintegration time limit is still kept after long-term placement, so that the technical problem to be solved in the prior art is urgently.
Disclosure of Invention
In order to solve the technical problems in the prior art, the invention provides the vitamin C effervescent granule and the preparation method thereof, which have short disintegration time at low temperature and still keep short disintegration time after long-term placement.
In order to solve the technical problems, the invention adopts the following technical scheme:
a preparation method of vitamin C effervescent granules comprises the steps of vitamin C pretreatment, stabilizer preparation, auxiliary agent preparation and granulation;
1. vitamin C pretreatment
Placing vitamin C powder in nitrogen atmosphere for plasma ball milling treatment, wherein the ball milling time is 24-26min, the discharge voltage is 6-10kV, the discharge current is 66-70mA, the discharge frequency is 26-28kHz, adding soybean phospholipid and xylitol after the plasma ball milling treatment is finished, and standing for 38-42min at 0.3-0.5 ℃ after uniformly mixing to obtain pretreated vitamin C;
the mass ratio of the vitamin C powder, the soybean lecithin and the xylitol is 3.6-3.8:0.8-1.2:0.3-0.5;
the particle size of the vitamin C powder is 115-125 meshes.
2. Preparation of the stabilizer
Placing mannitol in a closed container, pumping to vacuum degree of 72-76Pa, introducing nitrogen, controlling pressure at 83-85kPa, treating at 52-54 deg.C for 20-28min, adding sodium alginate, acacia and phytic acid, stirring, reducing pressure to 58-62kPa, treating at 60-64 deg.C for 16-20min, and obtaining stabilizer;
the mass ratio of mannitol, sodium alginate, acacia and phytic acid is 1.6-2.0:2.0-2.4:2.3-2.7:1.1-1.5.
3. Preparation auxiliary agent
Placing talcum powder at 340-360 ℃ for heat treatment for 35-45min, immediately cooling to-22 to-18 ℃ after heat treatment, and standing at-22 to-18 ℃ for 14-20min to obtain modified talcum powder; placing modified talcum powder into a ball mill for first ball milling treatment, controlling the ball-material ratio to be 4-8:1, the ball milling rotating speed to be 165-175rpm, the ball milling time to be 34-40min, the ball milling temperature to be 12-16 ℃, adding sorbitol and caprylic/capric glyceride after the first ball milling treatment is finished for second ball milling treatment, controlling the ball-material ratio to be 2-6:1, the ball milling rotating speed to be 200-220rpm, the ball milling time to be 26-30min, and the ball milling temperature to be 46-50 ℃ after the second ball milling treatment is finished, thus obtaining the auxiliary agent;
the particle size of the talcum powder is 105-115nm;
the mass ratio of the modified talcum powder to the sorbitol to the caprylic/capric glyceride is 1.2-1.4:2.5-2.9:2.0-2.2.
4. Granulating
(1) Preparation of particle one
Uniformly mixing lemon yellow with an ethanol solution, adding pretreated vitamin C, tartaric acid, a stabilizer and an auxiliary agent, uniformly mixing, granulating, and drying to obtain first granules;
the mass concentration of the ethanol solution is 70-74%;
the mass volume ratio of the lemon yellow to the ethanol solution is 0.2g:108-112ml;
the lemon yellow, the pretreated vitamin C, the stabilizer the mass ratio of the auxiliary agent to the tartaric acid is 1.3-1.5:178-182:12-14:6-8:1135-1145;
(2) Preparation of granules II
Mixing hydroxypropyl methylcellulose with deionized water, adding sunset yellow, stirring uniformly, adding sodium bicarbonate, sucralose, aspartame, a stabilizer and an auxiliary agent, granulating after mixing uniformly, and drying to obtain granules II;
the mass ratio of the hydroxypropyl methylcellulose to the deionized water is 1:9-11;
the mass ratio of the hydroxypropyl methylcellulose to the sunset yellow to the sodium bicarbonate to the sucralose to the aspartame to the stabilizing agent to the auxiliary agent is 4-6:7-9:1170-1230:380-420:34-36:16-18:7-9;
(3) Mixing
And packaging the first granules and the second granules according to the mass ratio of 10-15:85-90 to obtain the vitamin C effervescent granules.
Compared with the prior art, the invention has the following beneficial effects:
1. the vitamin C is pretreated by adopting a specific method, so that the activity of the vitamin C is improved, the dispersion performance is enhanced, and the vitamin C can be mixed with other components more uniformly; the vitamin C effervescent granule is mixed with a specific stabilizer and an auxiliary agent, the disintegration time limit at low temperature is short, the stability of the vitamin C effervescent granule is improved, and the disintegration time limit is still kept short after long-term placement;
2. the disintegration time of the vitamin C effervescent granule prepared by the invention is 75.1-80.6s at 5 ℃ and 74.6-79.3s at 45 ℃;
3. the vitamin C effervescent granule prepared by the invention is stood for 1 month in an environment with the temperature of 26 ℃ and the humidity of 45%, the disintegration time at 5 ℃ is 76.2-82.0s, the time is stood for 2 months, the disintegration time at 5 ℃ is 77.5-82.9s, the time is stood for 3 months, and the disintegration time at 5 ℃ is 78.1-83.7s;
standing at 26deg.C and humidity of 45% for 1 month, disintegration time at 45deg.C of 75.5-81.9s, standing for 2 months, disintegration time at 45deg.C of 76.2-83.1s, standing for 3 months, and disintegration time at 45deg.C of 76.7-84.1s;
3. the vitamin C effervescent granule prepared by the invention is stood for 1 month in an environment with the temperature of 45 ℃ and the humidity of 75 percent, the disintegration time at 5 ℃ is 77.6-83.4s, the standing is carried out for 2 months, the disintegration time at 5 ℃ is 79.4-85.7s, the standing is carried out for 3 months, and the disintegration time at 5 ℃ is 80.7-87.4s;
standing at 45deg.C and humidity of 75% for 1 month, disintegration time at 45deg.C of 75.9-82.7s, standing for 2 months, disintegration time at 45deg.C of 77.2-84.4s, standing for 3 months, and disintegration time at 45deg.C of 77.8-85.8s.
Detailed Description
For a clearer understanding of the technical features, objects and effects of the present invention, specific embodiments of the present invention will be described.
Example 1
A preparation method of vitamin C effervescent granules comprises the steps of vitamin C pretreatment, stabilizer preparation, auxiliary agent preparation and granulation;
1. vitamin C pretreatment
Placing vitamin C powder in nitrogen atmosphere for plasma ball milling treatment, wherein the ball milling time is 25min, the discharge voltage is 8kV, the discharge current is 68mA, the discharge frequency is 27kHz, adding soybean phospholipid and xylitol after the plasma ball milling treatment is finished, uniformly mixing, and standing at 0.4 ℃ for 40min to obtain pretreated vitamin C;
the mass ratio of the vitamin C powder to the soybean lecithin to the xylitol is 3.7:1.0:0.4;
the particle size of the vitamin C powder is 120 meshes.
2. Preparation of the stabilizer
Placing mannitol in a closed container, pumping to a vacuum degree of 74Pa, introducing nitrogen, controlling the pressure to 84kPa, controlling the temperature to 53 ℃ for 24min, adding sodium alginate, arabic gum and phytic acid, uniformly stirring, reducing the pressure to 60kPa, controlling the temperature to 62 ℃ for 18min, and obtaining the stabilizer after the treatment is finished;
the mass ratio of mannitol, sodium alginate, acacia and phytic acid is 1.8:2.2:2.5:1.3.
3. Preparation auxiliary agent
Placing talcum powder at 350 ℃ for heat treatment for 40min, immediately cooling to-20 ℃ after heat treatment, and standing at-20 ℃ for 17min to obtain modified talcum powder; placing modified talcum powder into a ball mill for first ball milling treatment, controlling the ball-material ratio to be 6:1, the ball milling rotating speed to be 170rpm, the ball milling time to be 37min, the ball milling temperature to be 14 ℃, adding sorbitol and caprylic/capric glyceride for second ball milling treatment after the first ball milling treatment is finished, controlling the ball-material ratio to be 4:1, the ball milling rotating speed to be 210rpm, the ball milling time to be 28min, the ball milling temperature to be 48 ℃, and preparing an auxiliary agent after the second ball milling treatment is finished;
the particle size of the talcum powder is 110nm;
the mass ratio of the modified talcum powder to the sorbitol to the caprylic/capric glyceride is 1.3:2.7:2.1.
4. Granulating
(1) Preparation of particle one
Uniformly mixing lemon yellow with an ethanol solution, adding pretreated vitamin C, tartaric acid, a stabilizer and an auxiliary agent, uniformly mixing, granulating, and drying to obtain first granules;
the mass concentration of the ethanol solution is 72%;
the mass volume ratio of the lemon yellow to the ethanol solution is 0.2 g/110 ml;
the mass ratio of the lemon yellow to the pretreated vitamin C to the stabilizing agent to the auxiliary agent to the tartaric acid is 1.4:180:13:7:1140;
(2) Preparation of granules II
Mixing hydroxypropyl methylcellulose with deionized water, adding sunset yellow, stirring uniformly, adding sodium bicarbonate, sucralose, aspartame, a stabilizer and an auxiliary agent, granulating after mixing uniformly, and drying to obtain granules II;
the mass ratio of the hydroxypropyl methylcellulose to the deionized water is 1:10;
the mass ratio of the hydroxypropyl methylcellulose to the sunset yellow to the sodium bicarbonate to the sucralose to the aspartame to the stabilizing agent to the auxiliary agent is 5:8:1200:400:35:17:8;
(3) Mixing
And packaging the first granules and the second granules according to the mass ratio of 12:88 to obtain the vitamin C effervescent granules.
Example 2
A preparation method of vitamin C effervescent granules comprises the steps of vitamin C pretreatment, stabilizer preparation, auxiliary agent preparation and granulation;
1. vitamin C pretreatment
Placing vitamin C powder in nitrogen atmosphere for plasma ball milling treatment, wherein the ball milling time is 24min, the discharge voltage is 6kV, the discharge current is 66mA, the discharge frequency is 26kHz, adding soybean phospholipid and xylitol after the plasma ball milling treatment is finished, uniformly mixing, and standing at 0.3 ℃ for 38min to obtain pretreated vitamin C;
the mass ratio of the vitamin C powder to the soybean lecithin to the xylitol is 3.6:0.8:0.3;
the particle size of the vitamin C powder is 115 meshes.
2. Preparation of the stabilizer
Placing mannitol in a closed container, pumping to vacuum degree of 72Pa, introducing nitrogen, controlling pressure to 83kPa, treating at 52 ℃ for 20min, adding sodium alginate, acacia and phytic acid, stirring uniformly, reducing pressure to 58kPa, treating at 60 ℃ for 16min, and obtaining the stabilizer after the treatment is finished;
the mass ratio of mannitol, sodium alginate, acacia and phytic acid is 1.6:2.0:2.3:1.1.
3. Preparation auxiliary agent
Placing talcum powder at 340 ℃ for heat treatment for 45min, immediately cooling to-18 ℃ after heat treatment, and standing at-18 ℃ for 20min to obtain modified talcum powder; placing modified talcum powder into a ball mill for first ball milling treatment, controlling the ball-material ratio to be 4:1, the ball milling rotating speed to be 165rpm, the ball milling time to be 34min, the ball milling temperature to be 12 ℃, adding sorbitol and caprylic/capric glyceride for second ball milling treatment after the first ball milling treatment is finished, controlling the ball-material ratio to be 2:1, the ball milling rotating speed to be 200rpm, the ball milling time to be 30min, the ball milling temperature to be 46 ℃, and preparing an auxiliary agent after the second ball milling treatment is finished;
the particle size of the talcum powder is 105nm;
the mass ratio of the modified talcum powder to the sorbitol to the caprylic/capric glyceride is 1.2:2.5:2.0.
4. Granulating
(1) Preparation of particle one
Uniformly mixing lemon yellow with an ethanol solution, adding pretreated vitamin C, tartaric acid, a stabilizer and an auxiliary agent, uniformly mixing, granulating, and drying to obtain first granules;
the mass concentration of the ethanol solution is 70%;
the mass volume ratio of the lemon yellow to the ethanol solution is 0.2g:108ml;
the mass ratio of the lemon yellow to the pretreated vitamin C to the stabilizing agent to the auxiliary agent to the tartaric acid is 1.3:178:12:6:1135;
(2) Preparation of granules II
Mixing hydroxypropyl methylcellulose with deionized water, adding sunset yellow, stirring uniformly, adding sodium bicarbonate, sucralose, aspartame, a stabilizer and an auxiliary agent, granulating after mixing uniformly, and drying to obtain granules II;
the mass ratio of the hydroxypropyl methylcellulose to the deionized water is 1:9;
the mass ratio of the hydroxypropyl methylcellulose to the sunset yellow to the sodium bicarbonate to the sucralose to the aspartame to the stabilizer to the auxiliary agent is 4:7:1170:380:34:16:7;
(3) Mixing
And packaging the first granules and the second granules according to the mass ratio of 10:90 to obtain the vitamin C effervescent granules.
Example 3
A preparation method of vitamin C effervescent granules comprises the steps of vitamin C pretreatment, stabilizer preparation, auxiliary agent preparation and granulation;
1. vitamin C pretreatment
Placing vitamin C powder in nitrogen atmosphere for plasma ball milling treatment, wherein the ball milling time is 26min, the discharge voltage is 10kV, the discharge current is 70mA, the discharge frequency is 28kHz, adding soybean phospholipid and xylitol after the plasma ball milling treatment is finished, uniformly mixing, and standing at 0.5 ℃ for 42min to obtain pretreated vitamin C;
the mass ratio of the vitamin C powder to the soybean lecithin to the xylitol is 3.8:1.2:0.5;
the particle size of the vitamin C powder is 125 meshes.
2. Preparation of the stabilizer
Placing mannitol in a closed container, pumping to a vacuum degree of 76Pa, introducing nitrogen, controlling the pressure to be 85kPa, controlling the temperature to be 54 ℃ for 28min, adding sodium alginate, arabic gum and phytic acid, uniformly stirring, reducing the pressure to 62kPa, controlling the temperature to be 64 ℃ for 20min, and obtaining the stabilizer after the treatment is finished;
the mass ratio of mannitol, sodium alginate, acacia and phytic acid is 2.0:2.4:2.7:1.5.
3. Preparation auxiliary agent
Placing talcum powder at 360 ℃ for heat treatment for 35min, immediately cooling to-22 ℃ after heat treatment, and standing at-22 ℃ for 14min to obtain modified talcum powder; placing modified talcum powder into a ball mill for first ball milling treatment, controlling the ball-material ratio to be 8:1, the ball milling rotating speed to be 175rpm, the ball milling time to be 40min, the ball milling temperature to be 16 ℃, adding sorbitol and caprylic/capric glyceride for second ball milling treatment after the first ball milling treatment is finished, controlling the ball-material ratio to be 6:1, the ball milling rotating speed to be 220rpm, the ball milling time to be 26min, the ball milling temperature to be 50 ℃ and preparing an auxiliary agent after the second ball milling treatment is finished;
the particle size of the talcum powder is 115nm;
the mass ratio of the modified talcum powder to the sorbitol to the caprylic/capric glyceride is 1.4:2.9:2.2.
4. Granulating
(1) Preparation of particle one
Uniformly mixing lemon yellow with an ethanol solution, adding pretreated vitamin C, tartaric acid, a stabilizer and an auxiliary agent, uniformly mixing, granulating, and drying to obtain first granules;
the mass concentration of the ethanol solution is 74%;
the mass volume ratio of the lemon yellow to the ethanol solution is 0.2g:112ml;
the mass ratio of the lemon yellow to the pretreated vitamin C to the stabilizing agent to the auxiliary agent to the tartaric acid is 1.5:182:14:8:1145;
(2) Preparation of granules II
Mixing hydroxypropyl methylcellulose with deionized water, adding sunset yellow, stirring uniformly, adding sodium bicarbonate, sucralose, aspartame, a stabilizer and an auxiliary agent, granulating after mixing uniformly, and drying to obtain granules II;
the mass ratio of the hydroxypropyl methylcellulose to the deionized water is 1:11;
the mass ratio of the hydroxypropyl methylcellulose to the sunset yellow to the sodium bicarbonate to the sucralose to the aspartame to the stabilizer to the auxiliary agent is 6:9:1230:420:36:18:9;
(3) Mixing
And packaging the first granules and the second granules according to the mass ratio of 15:85 to obtain the vitamin C effervescent granules.
Comparative example 1
On the basis of example 1, the pretreatment step for vitamin C was omitted, vitamin C without any treatment was directly used, and the rest of the operations were the same.
Comparative example 2
The procedure was as in example 1 except that the stabilizer and adjuvant components were omitted and the remainder was identical.
Performance testing
1. The products prepared in examples 1-3 and comparative examples 1-2 were placed in water at 5℃and 45℃respectively, the amounts of water were 100ml, and the disintegration time was recorded as follows:
2. (1) The products prepared in examples 1-3 and comparative examples 1-2 were placed in an environment at 26℃and 45% humidity respectively for 3 months, sampled at the end of month 1, at the end of month 2 and at the end of month 3 respectively, and then placed in water at 5℃and 45℃respectively, with water amounts of 100ml, and disintegration time(s) was recorded as follows:
(2) The products prepared in examples 1-3 and comparative examples 1-2 were placed in an environment at 45℃and 75% humidity respectively for 3 months, sampled at the end of month 1, at the end of month 2 and at the end of month 3 respectively, and then placed in water at 5℃respectively, with the amounts of water being 100ml, and the disintegration time(s) was recorded as follows:
the proportions described in the invention are mass proportions, and the percentages are mass percentages unless otherwise specified.
Finally, it should be noted that: the foregoing description is only a preferred embodiment of the present invention, and is not intended to limit the present invention, but although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the technical solutions described in the foregoing embodiments, or equivalents may be substituted for some of the technical features thereof. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (5)
1. The preparation method of the vitamin C effervescent granule is characterized by comprising the steps of vitamin C pretreatment, stabilizer preparation, auxiliary agent preparation and granulation;
the granulating step comprises the steps of preparing first granules, preparing second granules and mixing;
the vitamin C pretreatment step comprises the steps of placing vitamin C powder in nitrogen atmosphere for plasma ball milling treatment, wherein the ball milling time is 24-26min, the discharge voltage is 6-10kV, the discharge current is 66-70mA, the discharge frequency is 26-28kHz, adding soybean lecithin and xylitol after the plasma ball milling treatment is finished, mixing uniformly, and standing at 0.3-0.5 ℃ for 38-42min to obtain pretreated vitamin C;
the mass ratio of the vitamin C powder, the soybean lecithin and the xylitol is 3.6-3.8:0.8-1.2:0.3-0.5;
the preparation method of the stabilizer comprises the steps of placing mannitol in a closed container, pumping to a vacuum degree of 72-76Pa, introducing nitrogen, controlling the pressure to 83-85kPa, controlling the temperature to 52-54 ℃ for 20-28min, adding sodium alginate, arabic gum and phytic acid, uniformly stirring, reducing the pressure to 58-62kPa, controlling the temperature to 60-64 ℃ for 16-20min, and obtaining the stabilizer after the treatment is finished;
the mass ratio of mannitol, sodium alginate, acacia gum and phytic acid is 1.6-2.0:2.0-2.4:2.3-2.7:1.1-1.5;
the preparation auxiliary agent comprises the steps of placing talcum powder at 340-360 ℃ for heat treatment for 35-45min, immediately cooling to-22 to-18 ℃ after heat treatment, and standing at-22 to-18 ℃ for 14-20min to obtain modified talcum powder; placing modified talcum powder into a ball mill for first ball milling treatment, controlling the ball-material ratio to be 4-8:1, the ball milling rotating speed to be 165-175rpm, the ball milling time to be 34-40min, the ball milling temperature to be 12-16 ℃, adding sorbitol and caprylic/capric glyceride after the first ball milling treatment is finished for second ball milling treatment, controlling the ball-material ratio to be 2-6:1, the ball milling rotating speed to be 200-220rpm, the ball milling time to be 26-30min, and the ball milling temperature to be 46-50 ℃ after the second ball milling treatment is finished, thus obtaining the auxiliary agent;
the mass ratio of the modified talcum powder to the sorbitol to the caprylic/capric glyceride is 1.2-1.4:2.5-2.9:2.0-2.2;
the first step of preparing the granule comprises the steps of uniformly mixing lemon yellow with an ethanol solution, then adding the pretreated vitamin C, tartaric acid, a stabilizer and an auxiliary agent, uniformly mixing, granulating, and drying to prepare the first granule;
the mass volume ratio of the lemon yellow to the ethanol solution is 0.2g:108-112ml;
the lemon yellow, the pretreated vitamin C, the stabilizer the mass ratio of the auxiliary agent to the tartaric acid is 1.3-1.5:178-182:12-14:6-8:1135-1145;
mixing hydroxypropyl methylcellulose with deionized water, adding sunset yellow, stirring uniformly, adding sodium bicarbonate, sucralose, aspartame, a stabilizer and an auxiliary agent, granulating after uniformly mixing, and drying to obtain granules II;
the mass ratio of the hydroxypropyl methylcellulose to the deionized water is 1:9-11;
the mass ratio of the hydroxypropyl methylcellulose to the sunset yellow to the sodium bicarbonate to the sucralose to the aspartame to the stabilizing agent to the auxiliary agent is 4-6:7-9:1170-1230:380-420:34-36:16-18:7-9;
the mixing step is that the first granules and the second granules are packaged according to the mass ratio of 10-15:85-90 to prepare the vitamin C effervescent granules.
2. The method for preparing vitamin C effervescent granules as claimed in claim 1, characterized in that,
in the vitamin C pretreatment step, the particle size of the vitamin C powder is 115-125 meshes.
3. The method for preparing vitamin C effervescent granules as claimed in claim 1, characterized in that,
in the step of preparing the auxiliary agent, the talcum powder has the particle size of 105-115nm.
4. The method for preparing vitamin C effervescent granules as claimed in claim 1, characterized in that,
in the step of preparing the particles, the mass concentration of the ethanol solution is 70-74%.
5. Vitamin C effervescent granule, characterized in that it is obtained by the preparation method according to any one of claims 1 to 4.
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