CN102327233A - Dimercaptosuccinic acid granular formulation - Google Patents
Dimercaptosuccinic acid granular formulation Download PDFInfo
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- CN102327233A CN102327233A CN201110290211A CN201110290211A CN102327233A CN 102327233 A CN102327233 A CN 102327233A CN 201110290211 A CN201110290211 A CN 201110290211A CN 201110290211 A CN201110290211 A CN 201110290211A CN 102327233 A CN102327233 A CN 102327233A
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Abstract
The invention provides dimercaptosuccinic acid solid preparations, in particular to a dimercaptosuccinic acid granular formulation, which is prepared from dimercaptosuccinic acid and auxiliary materials, wherein the auxiliary materials are taste-masking preparation and one kind or more than two kinds of the following materials which are selected from the following groups: diluent, disintegrating agent, suspending agent, sweetener and bonding agent. The dimercaptosuccinic acid granular formulation is characterized in that the taste-masking preparation is beta-cyclodextrin and liquid cream flavor essence, and is prepared into the granular formulation through the following method: after the dimercaptosuccinic acid and the liquid cream flavor essence are mixed, and then the beta-cyclodextrin is added to be uniformly mixed. The dimercaptosuccinic acid granular formulation adopts the novel taste-masking technology, the garlic like smell of the dimercaptosuccinic acid is effectively masked, and meanwhile, the formulation has the pleasant fragrance and fruity taste, and is more suitable for children to take.
Description
Technical field
The present invention relates to a kind of succimer solid preparation, particularly succimer granule, with and preparation method thereof.Belong to field of pharmaceutical preparations.
Background technology
At present, concerning Therapeutic Method that heavy metal poisoning adopted is on its mechanism of action, generally there are two types.One type is chelating (complexation) mechanism of action, promptly combines the formation chelate with heavy metal element through chelating agen, excretes (like succimer) with urine etc.; Or form the chelate (like metallothionein) of nontoxic or low toxicity; Or form insoluble complex deposition (like pectin class natural polymer).Another kind of is to repel (antagonism) mechanism of action, belongs to divalent metal element together like elements such as calcium, ferrum, zinc and lead, and the competition effect is arranged in the metabolic process in vivo, in small intestinal the same delivery of competition conjugated protein, the supply of calcium can suppress the absorption of lead.
At this wherein, generally acknowledge determined curative effect certainly, developed into the medicinal chelating agen class that adopts chelation mechanism of having only.And this is main with sulfydryl class antidote wherein, like two mercapto propane sulfonic acid sodium (Na-DMPS), natrium dimercaptosuccinicum (Na-DMS), succimer (DMSA), dimercaprol (BAL) etc.The chelating antidote of using in addition also has penicillamine and calcium disodium edetate etc.Wherein with succimer, natrium dimercaptosuccinicum and and two mercapto propane sulfonic acid sodium the most frequently used clinically, all acute and chronic arsenic, mercurialism are all had tangible curative effect, the former two also also has good effect to plumbous, stibialism; Succimer because of because of oral effectively, uses very convenient, by domestic and international Plumbum removing medicine as first-selection.Dimercaprol is acute arsenic, a mercurialism antidote preferably, but because of toxicity is big, side effect is more, few using.Penicillamine is mainly used in treatment lead, mercurialism, but too late Ca-EDTA of curative effect and two mercapto propane sulfonic acid sodium, its great advantage is can be oral, but toxicity is bigger, and the copper that drives that is mainly used in hepatolenticular degeneration is at present treated.Mercaptamine is mainly used in acute tetraethyl lead poisoning, but curative effect is not certainly.
Compare with calcium disodium edetate and dimercaprol, oral succimer administration is more convenient, need not vein or intramuscular injection, and is easy for patients to accept, need not hospitalization in the therapeutic process, helps reducing medical expense.Drive plumbous preparation penicillamine and compare with tradition is oral, the maximum characteristics of succimer are can the selectivity Plumbum removing, and are driving plumbous mineral of also discharging needed by human such as a large amount of zinc, ferrum, calcium, copper simultaneously unlike penicillamine.
At present, succimer preparation both domestic and external has only a kind of dosage form of capsule, and Shang Weijian is fit to the special-purpose dosage form of children taking.The children taking succimer normally takes out the content in the capsule, mixes and stirs in a small amount of semi-solid foodstuff or blending is taken in fruit beverage, and the compliance of administration is relatively poor.
Summary of the invention
Single for overcoming in the prior art succimer preparation type, the defective of children poor compliance particularly, the present invention provides a kind of succimer solid preparation, particularly succimer granule.
Technical scheme of the present invention is following:
The present invention provides a kind of succimer solid preparation; Process by succimer and adjuvant; Wherein said adjuvant is an odor mask and be selected from following group one or more: diluent, disintegrating agent, suspending agent, sweeting agent, binding agent; It is characterized in that described odor mask is beta-schardinger dextrin-and liquid milk oil essence, and be to process: behind succimer and the liquid milk oil essence mixing, add beta-schardinger dextrin-again and carry out mixing through the method that comprises the steps.
Above-mentioned described succimer solid preparation, preferably, described succimer solid preparation is granule, capsule or tablet, is preferably granule.
Preferably; The present invention provides a kind of succimer granule; Processed by succimer and adjuvant, wherein said adjuvant is an odor mask and be selected from following group one or more: diluent, disintegrating agent, suspending agent, sweeting agent, binding agent is characterized in that described odor mask is beta-schardinger dextrin-and liquid milk oil essence; And be to process granule: behind succimer and the liquid milk oil essence mixing, add beta-schardinger dextrin-again and carry out mixing through the method that comprises the steps.
More preferably, above-mentioned described succimer granule is processed by succimer and adjuvant, and wherein said adjuvant is odor mask, diluent, disintegrating agent, suspending agent, sweeting agent and binding agent.
Wherein, Above-mentioned described solid preparation or granule; Described adjuvant can be conventional pharmaceutical adjuvant in this area, for example described diluent can in mannitol, cane sugar powder, lactose, starch, xylitol, maltose alcohol, starch milk saccharide complex, pregelatinized Starch, lactose, anhydrous glucose, the cyclodextrin one or more; Described disintegrating agent can in cross-linking sodium carboxymethyl cellulose, corn starch, potato starch, carboxylic first and Starch Sodium, low viscosity carboxylic first and Starch Sodium, the partially pregelatinized starch one or more; Described suspending agent can in xanthan gum, carbomer, tragakanta, sodium carboxymethyl cellulose, the sodium alginate one or more; Described sweeting agent can in stevioside, aspartame, maltose alcohol, sorbitol, glucose, high fructose, the neotame one or more; Described binding agent can in 30 POVIDONE K 30 BP/USP-30, maltodextrin, ethyl cellulose, the hypromellose one or more.
As preferably; Above-mentioned described succimer granule; Wherein: described diluent preferably sucrose and mannitol, the preferred cross-linking sodium carboxymethyl cellulose of described disintegrating agent, the preferred xanthan gum of described suspending agent; The preferred stevioside of described sweeting agent, the preferred hydroxypropyl cellulose-L of described binding agent.
More preferably, above-mentioned described succimer granule, wherein, count by weight percentage:
More preferably, above-mentioned described succimer granule is characterized in that it being the granule of processing through the method that comprises the steps:
(1) succimer and beta-schardinger dextrin-pulverize separately sieve; All the other solid adjuvant material crushing screenings;
(2) behind succimer and the liquid milk oil essence mixing, add the beta-schardinger dextrin-mixing, be the A material;
(3) behind stevioside, cross-linking sodium carboxymethyl cellulose and the xanthan gum mixing, add mannitol and cane sugar powder mixing, be the B material;
(4) above-mentioned A material is joined mixing in the B material, granulate with the alcoholic solution of 15% hydroxypropyl cellulose-L;
(5) promptly get after the wet grain drying that step (4) makes.
As preferred plan of the present invention, the present invention provides a kind of succimer granule, wherein, counts by weight percentage:
And be to process through the method for following steps:
(1) succimer and beta-schardinger dextrin-are crossed 100 mesh sieves respectively; All the other solid adjuvant materials are crossed 80 mesh sieves, preserve in the drying place, and cane sugar powder and beta-schardinger dextrin-moisture Control before use is below 0.5%;
(2) succimer that takes by weighing recipe quantity places high-speed stirred to granulate in the pot, stirs the liquid milk oil essence that adds recipe quantity down, stirs 5min, is weighed into the beta-schardinger dextrin-of recipe quantity then, stirs 5min, takes out subsequent usely, is that A expects;
(3) stevioside, cross-linking sodium carboxymethyl cellulose and the xanthan gum that take by weighing recipe quantity are respectively gone in the high-speed stirred granulation pot, stir 5min, add recipe quantity mannitol and cane sugar powder then, stir 10min, cross 80 mesh sieves, are that B expects;
(4) above-mentioned A material is joined in the B material, stirred 15 minutes, took out 80 mesh sieves, material returns to be put in the pot of granulating, and under agitation, in the alcoholic solution injecting material with 15% hydroxypropyl cellulose-L, processes suitable soft material at leisure, and soft material is granulated with 24 orders;
(5) wet grain is put 45 ± 2 ℃ of convection oven inner dryings, after dry 1h makes moisture be not more than 1.5%, takes out, with 24 mesh sieve granulate;
(6) carry out half-finished quality inspection, dry granular is packed with the clad aluminum foil bag after the assay was approved, every bag of 1.5g.
The present invention adopts novel taste masking technology, the Bulbus Allii appearance stink of succimer is effectively covered, and preparation of the present invention has pleasant fragranced and fruity, children taking preferably.And, to compare with existing Chemet, indexs such as succimer preparation stability of the present invention, dissolution are good, meet the clinical application demand.
With the succimer granule that embodiment 1 makes, carry out influence factor's test.
A) exposure experiments to light is got these article and is gone outer package, and content places culture dish, spreads out into the thick thin layer of 3-4mm, is placed in the lighting box, and in the condition held of 4500Lx illuminance 10 days, the analysis of taking a sample to check in 5,10 days, result and zero day sample are relatively.
B) hot test is got these article and is gone outer package, and content places culture dish, spreads out into the thick thin layer of 3-4mm, and in 60 ℃ temperature held 10 days, the analysis of taking a sample to check in 5,10 days, result and zero day sample are relatively.
C) high wet test is got these article and is gone outer package; Granule places culture dish; Spread out into the thick thin layer of 3-4mm, place 25 ℃ of room temperatures, in relative humidity 92.5% (saturated KNO3 solution) and relative humidity 75% (the saturated Nacl solution) environment 10 days; The analysis of taking a sample to check in 5,10 days, result and zero day sample are relatively.
Content of examination: the character of sample, acidity, loss on drying, settling volume ratio, content, related substance etc.Measured data and 0 day data compare, and the result sees table 1.
Table 1 influence factor tests testing result
Influence factor's result of the test shows:
(1) these article were placed 10 days through 60 ℃ of high temperature, and related substance is increased to 1.15% from 0.65%, increases about 1 times, is significant change, and all other indexs have no significant change.These article of explanation are unstable under hot environment, and related substance can raise, so these article should store in the cool.
(2) these article were placed 10 days through the 4500lux strong illumination, and related substance is increased to 0.86% from 0.65%, had increased approximately more than 32%, were significant change.All other indexs do not have significant change.These article of explanation answer lucifuge to store.
(3) these article were placed 10 days through RH75%, 25 ℃, and related substance is increased to 1.40% from 0.65%, increased approximately more than 1 times, were utmost point significant change.All other indexs do not have significant change.These article of explanation should store at the drying place.These article were placed 10 days through RH90%, 25 ℃, and sample moisture absorption weightening finish surpasses 10% and form a lump, no longer tests by regulation.
Combined influence factorial experiments result shows that these article are unstable under high temperature, high humidity and strong illumination condition, and related substance can raise; " be stored in 15～25 ℃ of environment; avoid overheated " simultaneously with reference to the condition of storage of homemade Chemet (Shanghai Xinya Pharmaceutical Industry Minhang Co., Ltd.) " shading, airtight, preserve in the cool " and the condition of storage of U.S.'s Chemet (trade name CHEMET); So these article are answered shading, sealing is located to preserve shady and cool (being no more than 25 ℃).
The study on the stability sample preparation
According to prescription and the prepared succimer granule of embodiment 1, and according to the test of drug research study on the stability, the character of sample survey, acidity, granularity, uniformity of dosage units, content, related substance, dissolution etc., the result sees table 2.
The result of the test of three batches of study on the stability samples of table 2 gathers
The result shows: the quality of above-mentioned three batches of study on the stability samples all meets the clinical application requirement, explains that succimer preparation of the present invention has repeatability and operability preferably.
The specific embodiment
Embodiment 1:
Prescription: (W/W)
Preparation technology:
1. succimer and beta-schardinger dextrin-are crossed 100 mesh sieves respectively; All the other solid adjuvant materials are crossed 80 mesh sieves, preserve in the drying place.Cane sugar powder and betacyclodextrin moisture before use must be controlled at below 0.5%.
2. the succimer that takes by weighing recipe quantity places in the high-speed stirred granulation pot, stirs the liquid milk oil essence of (main stirring paddle 150rpm, cutter 800rpm) adding recipe quantity down, stirring 5min; Be weighed into the beta-schardinger dextrin-of recipe quantity then; Stirring 5min, takes out subsequent usely, is that A expects.
3. the stevioside, cross-linking sodium carboxymethyl cellulose and the xanthan gum that take by weighing recipe quantity are respectively gone in the high-speed stirred granulation pot; Stir (main stirring paddle 150rpm, cutter 800rpm) 5min, add recipe quantity mannitol and cane sugar powder then, stir 10min; Cross 80 mesh sieves, be the B material.
4. above-mentioned A material is joined in the B material, stirred (main stirring paddle 150rpm, cutter 800rpm) 15 minutes; Took out 80 mesh sieves; Material returns to be put in the pot of granulating, under agitation, and at leisure with in 15% hydroxypropyl cellulose-L-alcoholic solution injecting material; Process suitable soft material, soft material is granulated with 24 orders.
5. wet grain is put 45 ± 2 ℃ of convection oven inner dryings, after dry 1h makes moisture be not more than 1.5%, takes out, with 24 mesh sieve granulate.
6. carry out half-finished quality inspection.
7. dry granular is packed with the clad aluminum foil bag after the assay was approved, every bag of 1.5g.
Comparative Examples:
1, according to composition and the technology of embodiment 1, changes odor mask, investigate the taste masking effect with different adding modes through adding dissimilar essence.The inventory of test is 100 bags (150g) of each prescription, and prescription and result of the test are seen table 3.
The taste masking effect of the different odor masks of table 3.
In add *: with succimer in advance with the essence mixing, and then mix the back with other adjuvant and granulate.
Add * *: granulate earlier, then with back, the surface mixing of essence spray solution to dry granular; Or with solid essence powder and dry granular mixing.
Though 2 above-mentioned prescriptions eight have taste masking effect preferably, still have slight stink in the sample, and after 40 ℃ of acceleration were examined one month, stink can increase the weight of, because this strain is given children taking, need accomplish not have stink, and mouthfeel is good, and the child is glad to take.This test utilizes beta-schardinger dextrin-can wrap up the performance of micromolecular compound; Succimer and essence are wrapping in the beta-schardinger dextrin-cavity; Make medicine and essence to be bound in for a long time in the beta-schardinger dextrin-, promptly reach and hinder stink and raise outward and can keep fragrance effects enduringly.
At prescription eight is to add beta-schardinger dextrin-on the basis, and prescription and result see table 4.
Table 4. beta-schardinger dextrin-strengthens the effect of taste masking
3, odor mask adds the influence of mode and inferior ordered pair taste masking effect
This EXPERIMENTAL DESIGN three kinds of adding modes:
Mode one: put beta-schardinger dextrin-earlier, stir adding medicine down, stirring and evenly mixing adds liquid essence then, stirs 5min.
Mode two: put beta-schardinger dextrin-earlier, stir adding liquid essence down, stirring and evenly mixing adds medicine then, stirs 5min.
Mode three: put medicine earlier, stir adding liquid essence down, stirring and evenly mixing adds medicine then, stirs 5min.
The method of the prepared samples using nasil of three kinds of adding modes is judged the weight of preparation stink.
Preparation technology is following:
Mode one:
1. in high speed shear granulation pot, be weighed into the beta-schardinger dextrin-of recipe quantity, stir adding recipe quantity succimer down, after stirring makes mixing, add the liquid essence of recipe quantity again, stir and make mixing, for the A material, subsequent use.
2. in high speed shear is granulated pot, be weighed into the adjuvant of residue recipe quantity, stir and make mixing, take out; Cross 80 mesh sieves once, material returns to be put in the pot, adds the A material; Stirring makes mixing, takes out 80 mesh sieves once, returns and puts in the pot; It is an amount of to add 15% hydroxypropyl cellulose-L-alcoholic solution, processes suitable soft material, takes out and granulates with 24 mesh sieves.
3. wet grain is put 50 ℃ of exsiccators and is dried to moisture content below 1.5%, with 24 order granulate, promptly gets.
Mode two:
1. in high speed shear granulation pot, be weighed into the beta-schardinger dextrin-of recipe quantity, stir adding recipe quantity liquid essence down, after stirring makes mixing, add the succimer of recipe quantity again, stir and make mixing, for the A material, subsequent use.
2. in high speed shear is granulated pot, be weighed into the adjuvant of residue recipe quantity, stir and make mixing, take out; Cross 80 mesh sieves once, material returns to be put in the pot, adds the A material; Stirring makes mixing, takes out 80 mesh sieves once, returns and puts in the pot; It is an amount of to add 15% hydroxypropyl cellulose-L-alcoholic solution, processes suitable soft material, takes out and granulates with 24 mesh sieves.
3. wet grain is put 50 ℃ of exsiccators and is dried to moisture content below 1.5%, with 24 order granulate, promptly gets.
Mode three:
1. in high speed shear granulation pot, be weighed into the succimer of recipe quantity, stir adding recipe quantity liquid essence down, after stirring makes mixing, add the beta-schardinger dextrin-of recipe quantity again, stir and make mixing, for the A material, subsequent use.
2. in high speed shear is granulated pot, be weighed into the adjuvant of residue recipe quantity, stir and make mixing, take out; Cross 80 mesh sieves once, material returns to be put in the pot, adds the A material; Stirring makes mixing, takes out 80 mesh sieves once, returns and puts in the pot; It is an amount of to add 15% hydroxypropyl cellulose-L-alcoholic solution, processes suitable soft material, takes out and granulates with 24 mesh sieves.
3. wet grain is put 50 ℃ of exsiccators and is dried to moisture content below 1.5%, with 24 order granulate, promptly gets.
Evaluation of test result:
Evaluation methodology: the method for employing nasil is heard the garlic odour flavor of succimer in the preparation, makes comparisons with the stink of succimer crude drug itself, and it is excellent not going out stink with basic news.
The result of test shows that mode one all still has slight stink with the sample of mode two preparations, and mode three does not snuff stink basically.Result of the test shows, after liquid essence is adsorbed to medical surfaces earlier, integrally is wrapped in the cavity by beta-schardinger dextrin-again then, thereby has reached good taste masking effect.
Claims (8)
1. succimer solid preparation; Process by succimer and adjuvant; Wherein said adjuvant is an odor mask and be selected from following group one or more: diluent, disintegrating agent, suspending agent, sweeting agent, binding agent; It is characterized in that described odor mask is beta-schardinger dextrin-and liquid milk oil essence, and be to process: behind succimer and the liquid milk oil essence mixing, add beta-schardinger dextrin-again and carry out mixing through the method that comprises the steps.
2. succimer solid preparation according to claim 1, it is granule, capsule or tablet, is preferably granule.
3. succimer granule; Process by succimer and adjuvant; Wherein said adjuvant is an odor mask and be selected from following group one or more: diluent, disintegrating agent, suspending agent, sweeting agent, binding agent; It is characterized in that described odor mask is beta-schardinger dextrin-and liquid milk oil essence, and be to process granule: behind succimer and the liquid milk oil essence mixing, add beta-schardinger dextrin-again and carry out mixing through the method that comprises the steps.
4. succimer granule according to claim 3 is processed by succimer and adjuvant, and wherein said adjuvant is odor mask, diluent, disintegrating agent, suspending agent, sweeting agent and binding agent.
5. succimer granule according to claim 4; Wherein: described diluent preferably sucrose and mannitol; The preferred cross-linking sodium carboxymethyl cellulose of described disintegrating agent; The preferred xanthan gum of described suspending agent, the preferred stevioside of described sweeting agent, the preferred hydroxypropyl cellulose-L of described binding agent.
6. succimer granule according to claim 5, wherein, count by weight percentage:
7. succimer granule according to claim 6 is characterized in that it being the granule of processing through the method that comprises the steps:
(1) succimer and beta-schardinger dextrin-pulverize separately sieve; All the other solid adjuvant material crushing screenings;
(2) behind succimer and the liquid milk oil essence mixing, add the beta-schardinger dextrin-mixing, be the A material;
(3) behind stevioside, cross-linking sodium carboxymethyl cellulose and the xanthan gum mixing, add mannitol and cane sugar powder mixing, be the B material;
(4) above-mentioned A material is joined mixing in the B material, granulate with the alcoholic solution of 15% hydroxypropyl cellulose-L;
(5) promptly get after the wet grain drying that step (4) makes.
8. succimer granule, wherein, count by weight percentage:
And be to process through the method for following steps:
(1) succimer and beta-schardinger dextrin-are crossed 100 mesh sieves respectively; All the other solid adjuvant materials are crossed 80 mesh sieves, preserve in the drying place, and cane sugar powder and beta-schardinger dextrin-moisture Control before use is below 0.5%;
(2) succimer that takes by weighing recipe quantity places high-speed stirred to granulate in the pot, stirs the liquid milk oil essence that adds recipe quantity down, stirs 5min, is weighed into the beta-schardinger dextrin-of recipe quantity then, stirs 5min, takes out subsequent usely, is that A expects;
(3) stevioside, cross-linking sodium carboxymethyl cellulose and the xanthan gum that take by weighing recipe quantity are respectively gone in the high-speed stirred granulation pot, stir 5min, add recipe quantity mannitol and cane sugar powder then, stir 10min, cross 80 mesh sieves, are that B expects;
(4) above-mentioned A material is joined in the B material, stirred 15 minutes, took out 80 mesh sieves, material returns to be put in the pot of granulating, and under agitation, in the alcoholic solution injecting material with 15% hydroxypropyl cellulose-L, processes suitable soft material at leisure, and soft material is granulated with 24 orders;
(5) wet grain is put 45 ± 2 ℃ of convection oven inner dryings, after dry 1h makes moisture be not more than 1.5%, takes out, with 24 mesh sieve granulate;
(6) carry out half-finished quality inspection, dry granular is packed with the clad aluminum foil bag after the assay was approved, every bag of 1.5g.
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| CN201110290211.XA CN102327233B (en) | 2011-09-28 | 2011-09-28 | Dimercaptosuccinic acid granular formulation |
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| CN201110290211.XA CN102327233B (en) | 2011-09-28 | 2011-09-28 | Dimercaptosuccinic acid granular formulation |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107449844A (en) * | 2017-08-30 | 2017-12-08 | 合肥立方制药股份有限公司 | A kind of method for determining Succimer preparation dissolution rate |
| CN108014345A (en) * | 2016-10-28 | 2018-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | One kind carries medicine silica dioxide nano particle and its preparation method and application |
| CN113069496A (en) * | 2021-03-18 | 2021-07-06 | 济川药业集团有限公司 | Traditional Chinese medicine granule composition for treating infantile common cold and preparation method thereof |
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| CN1241429A (en) * | 1998-07-13 | 2000-01-19 | 昆明冶金职业病防治中心 | Medicine for preventing chronic lead poisoning |
| CN1418884A (en) * | 2002-12-19 | 2003-05-21 | 北京师范大学 | 99TcMN dimercaptosuccinate compound, its preparation process and application in nucleic medicine science |
| CN1616112A (en) * | 2004-10-13 | 2005-05-18 | 复旦大学附属肿瘤医院 | Rhenium nuclide labelled dimercapto succinic acid preparation kit and its preparing method |
| US20070210006A1 (en) * | 2006-03-10 | 2007-09-13 | Council Of Scientific And Industrial Research | Surface-Modified Zeolite and Process for Synthesis Thereof for Sequestration of Anions |
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- 2011-09-28 CN CN201110290211.XA patent/CN102327233B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1241429A (en) * | 1998-07-13 | 2000-01-19 | 昆明冶金职业病防治中心 | Medicine for preventing chronic lead poisoning |
| CN1418884A (en) * | 2002-12-19 | 2003-05-21 | 北京师范大学 | 99TcMN dimercaptosuccinate compound, its preparation process and application in nucleic medicine science |
| CN1616112A (en) * | 2004-10-13 | 2005-05-18 | 复旦大学附属肿瘤医院 | Rhenium nuclide labelled dimercapto succinic acid preparation kit and its preparing method |
| US20070210006A1 (en) * | 2006-03-10 | 2007-09-13 | Council Of Scientific And Industrial Research | Surface-Modified Zeolite and Process for Synthesis Thereof for Sequestration of Anions |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108014345A (en) * | 2016-10-28 | 2018-05-11 | 中国人民解放军军事医学科学院毒物药物研究所 | One kind carries medicine silica dioxide nano particle and its preparation method and application |
| CN108014345B (en) * | 2016-10-28 | 2020-09-11 | 中国人民解放军军事医学科学院毒物药物研究所 | Drug-loaded silica nanoparticle and preparation method and application thereof |
| CN107449844A (en) * | 2017-08-30 | 2017-12-08 | 合肥立方制药股份有限公司 | A kind of method for determining Succimer preparation dissolution rate |
| CN107449844B (en) * | 2017-08-30 | 2020-05-08 | 合肥立方制药股份有限公司 | Method for determining dissolution rate of dimercaptosuccinic acid preparation |
| CN113069496A (en) * | 2021-03-18 | 2021-07-06 | 济川药业集团有限公司 | Traditional Chinese medicine granule composition for treating infantile common cold and preparation method thereof |
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| Publication number | Publication date |
|---|---|
| CN102327233B (en) | 2016-05-04 |
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Address after: 570216 Haikou Road, Nanhai District, Hainan, No. 168, No. Patentee after: Kang pharmaceutical Limited by Share Ltd Address before: 570216 Haikou Road, Nanhai District, Hainan, No. 168, No. Patentee before: Hainan Honz Pharmaceutical Co., Ltd. |