CN106562438A - Immunity enhancement composition and preparation method thereof - Google Patents
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- CN106562438A CN106562438A CN201610964502.5A CN201610964502A CN106562438A CN 106562438 A CN106562438 A CN 106562438A CN 201610964502 A CN201610964502 A CN 201610964502A CN 106562438 A CN106562438 A CN 106562438A
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- 239000005720 sucrose Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 229960004016 sucrose syrup Drugs 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 230000032258 transport Effects 0.000 description 1
- NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses an immunity enhancement composition which comprises the following components by weight: 50-200 parts of sodium vitamin C, 0.1-1 part of vitamin A, 10-30 parts of zinc gluconate, 10-30 parts of taurine, 10-20 parts of flower and fruit extract and 10-20 parts of spirulina powder. The immunity enhancement composition aims at the problems that vitamin C chewable tablets in the prior art, after dissolving, are highly-acid, have big stimulative effect to mouth cavity, throat, esophagus and gastric mucosa, is not suitable for long-term use, and in the storage process, vitamin C is prone to oxidize and inactivate, the vitamin C chewable tablets are easily affected with damp, the immunity enhancement composition has the effects of strengthening immunity, clearing heat and removing toxicity, lowering blood pressure, blood glucose and blood lipid, resisting cancer, beautifying and the like, and also can alleviate fatigue, supplement nutrition needed by human body and delay aging.
Description
Technical field
The invention belongs to medicine, health food, field of food, are related to a kind of composite preparation and preparation method thereof, especially
It is to be related to a kind of compositionss of enhancing immunity and preparation method thereof.
Background technology
Modern is due to being busy with one's work, diet such as does not note at the reason at ordinary times, causes the hypoimmunity of many people, body
All in sub-health state, if do not noted developing into disease even threat to life.With growth in the living standard, people couple
Health also pay attention to day by day, the product that it is desirable to use be also safely and effectively, and " integration of edible and medicinal herbs " class Chinese medicine and some have
The melon and fruit of health-care effect meets the treatment disease of people, health care demand.The present invention adds suitably " medicine food on the basis of Western medicine
It is homologous " class Chinese medicine, a kind of compositionss of enhancing immunity are made, this compositions contains abundant nutrient substance and improves human body is good for
The effective ingredient of health, the effects such as with enhancing immunity, heat-clearing and toxic substances removing, blood pressure lowering, blood glucose, blood fat, anticancer, looks improving and the skin nourishing, also
The nutrition of needed by human body, fatigue alleviating, slow down aging can be supplemented, particular for women, the U.S. face of being healthy and strong of middle-aged and elderly people, anti-ageing
The rehabilitation of the cancer patient of old and hypoimmunity.
Vitamin C is clinical basic common drug or supplementary, is the one kind in the middle of antioxidant vitaminses, and it participates in
Internal hydroxylation reaction, to be formed, glue between skeleton, tooth, connective tissue and non-Epithelial cell thing required, can maintain tooth,
The normal function of skeleton, blood vessel, increases the resistivity to disease, and one of nutrient necessary to be human body is widely used in
Various disease prevention and treatment.Sodium ascorbate is ascorbic sodium salt, the close neutrality of pH value of water solution, its effect and dimension life
Plain C is identical, but due to being sodium salt, so performance is more stable, while there is no longer ascorbic highly acid, can for a long time with it is various
Medicine is taken simultaneously, better than vitamin C.
Tablet quality is stable, taking convenience, is a kind of most basic, the most frequently used dosage form.However, for child, old
People and the patient of dysphagia, conventional tablet often take difficulty, and Long-term taking medicine can even make which produce psychological refusing to take medicine
Phenomenon, chewable tablet then can remedy such and insufficients.Chewable tablet is the tablet that a class can be chewed in oral cavity under posterior phraynx, size typically with
Conventional tablet is identical, can make Special-shaped sheet of different shapes as needed.Tablet is easy to swallow Jing after chewing, and coat tablets product increases
Greatly, medicine dissolving in vivo can be promoted, is absorbed.For the medicine of difficult disintegrate, make chewable tablet and can accelerate its disintegrate, improve medicine
Effect.Chewable tablet taking convenience, though under conditions of hydropenia can also medication on time, be particularly well-suited to children, old man, swallow it is tired
The poor patient of difficult or gastrointestinal function, can reduce medicine and gastrointestinal is born.Therefore, chewable tablet application gradually extensively rises
Come.
The content of the invention
The present invention for it is acid big after the existing dissolving containing Chewable C, oral cavity, throat esophagus and gastric mucosa are pierced
Swash larger, unsuitable long-term taking, and the problems such as the easy oxidation deactivation of vitamin C, the easy moisture absorption of chewable tablet are made moist in storing process, carry
A kind of compositionss of the effects such as there is heat-clearing and toxic substances removing, blood pressure lowering, blood glucose, blood fat, anticancer, looks improving and the skin nourishing simultaneously for enhancing immunity
And preparation method thereof, solve clinically using vitamin C exist quality it is unstable, be difficult long-term taking the problems such as.This
The compositionss of invention enhancing immunity, it is safe and free of toxic and side effects, can be used for for a long time improving hypoimmunity and woman woman, in it is old
The rehabilitation of the cancer patient of be healthy and strong U.S. face, defying age and the hypoimmunity of year people；Or as supplementary long-term taking.
To solve above-mentioned technical problem, the present invention is achieved by the following technical solutions：
A kind of compositionss of enhancing immunity, including the component of following weight portion：Sodium ascorbate 50-200 part, vitamin
A0.1-1 parts, zinc gluconate 10-30 parts, taurine 10-30 parts, flowers and fruits extract 10-20 parts, Spirulina powder 10-20 parts.
The above flowers and fruits extract is made up of the raw material of following weight portion：Camellia nitidissima Chi 20-40 parts, fresh Fructus Mori 30-60 parts.
The preparation method of the above flowers and fruits extract is：
S1：Raw material is weighed by following weight portion：Camellia nitidissima Chi 5-10 parts, fresh Fructus Mori 30-60 parts；
S2：Load weighted Camellia nitidissima Chi is taken, plus 6-10 times is measured water, is soaked 30 minutes, is extracted 2-3 time, each 30-40 minutes,
Filtration, obtains colored extracting solution；
S3：Load weighted fresh Fructus Mori are taken, is cleaned, is squeezed natural juice, filtered, obtain fruit juice；
S4：Flower extracting solution is mixed with fruit juice, less than 80 DEG C concentrating under reduced pressure, when obtaining 60 DEG C, relative density is 1.18-1.22
Fluid extract, fluid extract is dried, baking temperature is controlled for 65-80 DEG C, is obtained flowers and fruits extract.
Under the step S2 item, extracting method is preferably heating and refluxing extraction, supersound extraction.
Under the step S4 item, drying meanss are preferably baking oven for heating and are dried, are spray-dried.
The compositionss of above-described enhancing immunity, the preferably component also including following weight portion：Starch 200-400
Part, Mannitol 5-20 part, Microcrystalline Cellulose 20-60 part, PVP K-30 5-20 parts, carboxymethyl starch sodium 10-50 parts, 12
Alkyl sodium sulfate 5-20 parts, magnesium stearate 1-5 part, sweeting agent 10-30 parts, Mint Essence 0.1-0.5 parts.
The compositionss of above-described enhancing immunity, most preferably preferably include the component of following weight portion：Sodium ascorbate
120 parts, 0.5 part of vitamin A, 20 parts of zinc gluconate, 20 parts of taurine, 15 parts of flowers and fruits extract, 15 parts of Spirulina powder, form sediment
300 parts of powder, 12 parts of Mannitol, 40 parts of Microcrystalline Cellulose, 13 parts of PVP K-30,30 parts of carboxymethyl starch sodium, dodecyl sulfur
12 parts of sour sodium, 3 parts of magnesium stearate, 20 parts of sweeting agent, 0.3 part of Mint Essence.
The above flowers and fruits extract is made up of the raw material of following weight portion：30 parts of Camellia nitidissima Chi, 45 parts of fresh Fructus Mori.
The compositionss of the above enhancing immunity, the sweeting agent are preferably aspartame, neotame, mogroside.
The preparation method of the compositionss of the above enhancing immunity, comprises the steps：
T1：The preparation of flowers and fruits extract：Following raw material is weighed by weight：Camellia nitidissima Chi 20-40 parts, fresh Fructus Mori 30-60 parts；
Load weighted Camellia nitidissima Chi is taken, plus 6-10 times is measured water, is soaked 30 minutes, is extracted 2-3 time, each 30-40 minutes, filtration must be spent and be carried
Take liquid；Load weighted fresh Fructus Mori are taken, is cleaned, is squeezed natural juice, filtered, obtain fruit juice；Flower extracting solution is mixed with fruit juice, less than 80 DEG C
Concentrating under reduced pressure, when obtaining 60 DEG C, relative density is the fluid extract of 1.18-1.22, and fluid extract is dried, and controlling baking temperature is
65-80 DEG C, obtain flowers and fruits extract；
T2：Sodium ascorbate, vitamin A, zinc gluconate, taurine, flowers and fruits extract, Spirulina powder, shallow lake are taken respectively
Powder, Mannitol, Microcrystalline Cellulose, PVP K-30, carboxymethyl starch sodium, sodium lauryl sulphate, sweeting agent, crush, and cross 100
Mesh sieve, it is standby；
T3. each supplementary material under T1 items is weighed by formula ratio respectively, with equal increments method mix homogeneously, obtain mixed powder；
T4. the mixed powder under T3 items is taken, is stirred and is added 70-80% ethanol solution soft materials, granulation of sieving, be dried
4 hours, it was 2-4% to control moisture, and sieve granulate, obtains granule；
T5. magnesium stearate, Mint Essence are weighed by formula ratio, is mixed homogeneously with granule under S3 items, tabletting is obtained final product.
Under the step T4 item, dry temperature is preferably 60-65 DEG C, and the pellet hardness for so obtaining is moderate, is more beneficial for
Tabletting；Screen cloth under the step T4 item used by described sifting step is preferably 14-30 mesh.
The invention has the beneficial effects as follows：
1. the present invention overcome it is acid big after the existing dissolving containing Chewable C, to oral cavity, throat esophagus and gastric mucosa
The problems such as stimulation is larger, unsuitable long-term taking, and the easy oxidation deactivation of vitamin C, the easy moisture absorption of chewable tablet are made moist in storing process,
Make product stability more preferably, curative effect is more precisely, it is adaptable to consumer or patient's long-term taking, has no side effect.
2. in side of the present invention, each raw material and spirulina of flowers and fruits extract are " integration of edible and medicinal herbs " kind, safety non-toxic pair
Effect.Wherein Camellia nitidissima Chi is the high plant of a kind of medical value, health value, is that Guangxi is peculiar, belongs to nontoxic level, contains 400
Various nutrient substance, Jing researchs show Camellia nitidissima Chi for regulation human body blood fat, blood glucose, cholesterol, and enhancing human body immunity power has bright
Aobvious effect, is used for refreshment, clearing away liver-fire, relieving heat toxin, foster vigour always among the people；Fructus Mori, sweet in the mouth are cold in nature, containing rich
The various active compositions such as rich activated protein, vitamin, aminoacid, carotene, mineral, flavone, with strengthening human immunity
The effects such as power, nutrition skin, slow down aging, promoting the production of body fluid to quench thirst, facilitating digestion, the liver and the kidney tonifying, nourishing YIN and supplementing blood, it is referred to as " sage among the people
Really "；Spirulina, containing abundant high quality protein, bata-carotene, vitamin and various trace element needed by human, spiral shell
Also contain very high gamma-Linolenic acid in rotation algae, with strengthening immune system, defying age, resisting fatigue, blood pressure lowering, blood glucose, blood fat, anti-
Tumor etc. is acted on, and as its health-care effect is extremely strong, is referred to as optimal environmental protective hygienic food；Three of the above raw material, by with
The western medicine composition reasonable preparation such as sodium ascorbate, with enhancing immunity, heat-clearing and toxic substances removing, blood pressure lowering, blood glucose, blood fat, anticancer, U.S.
The effects such as holding skin care, nutrition, fatigue alleviating supplemented with needed by human body, slow down aging, particular for women, middle-aged and elderly people
Be healthy and strong U.S. face, defying age and hypoimmunity cancer patient rehabilitation.
3. compositionss of enhancing immunity of the present invention, preparation are easy, and mobility of particle is good, tabletting not sticking, obtained
Tablet surface is smooth, is difficult moisture absorption, and sweet mouthfeel, steady quality, beneficial to carrying, instant edible, are particularly suited for child, old age
People and the patient that can not swallow solid preparation, bioavailability are high, using safer and more effective, can be taken as nutritional supplementation liquid for a long time
With.
Specific embodiment
Although this specification is drawn a conclusion by particularly pointing out and clearly claiming claims of the present invention, should
This believes that following explanation is better understood with the present invention.
As used herein, word " preferred " and variant refer to this that can provide specific beneficial effect in certain circumstances
Bright embodiment.However, other embodiments it is identical or other in the environment of can also be preferred.Additionally, one
Or the detailed description of multiple preferred embodiments to be not offered as other embodiments be useless, and be not intended to from scope of the invention
Exclude other embodiments.
First, formulation conditions screening
1. wetting agent is selected
Wetting agent can make powder moistening, viscosity is presented, is beneficial to and prepares granule, be pressed into tablet.The present invention compared for dry method
Tabletting, wet granulation tabletting again, compressing dry granulation are bad using conventional tablet machines effect, high to equipment requirements, therefore the present invention is adopted
Wet granulation tabletting again.20% maltodextrin, 30% starch slurry, 40% sucrose syrup, 5% hypromellose are compared in test
Plain aqueous solution, 80% ethanol do wetting agent, the results are shown in Table 1.
1 wetting agent of table investigates result table
Knowable to the result of the test in table 1:The present invention is best using 80% alcohol granulation situation effect, therefore moistening of the present invention
Agent selects ethanol.Further to optimize concentration of alcohol, the present invention continues optimization concentration of alcohol, and result of the test is shown in Table 2.
2 concentration of alcohol of table investigates result table
| Sequence number | Wetting agent | Granulation situation | Particle appearance |
| 1 | 50% ethanol | Agglomerating, granulation is difficult | Granule is tight |
| 2 | 60% ethanol | Agglomerating, granulation is difficult | Granule is tight |
| 3 | 70% ethanol | Agglomerating, granulation is not lumpd | Granule is elastic suitable |
| 4 | 80% ethanol | Agglomerating, granulation is not lumpd | Granule is elastic suitable |
| 5 | 90% ethanol | Not agglomerating, granulation is difficult | Granule pine |
Knowable to the result of the test in table 2:Using 70%-80% alcohol granulation situations effect preferably, concentration is low for the present invention
Too tight, concentration Gao Taisong affects granulation, therefore wetting agent of the present invention selects 70%-80% ethanol.
2. the selection of lubricant
It is the mobility for increasing granule during tabletting, makes that filling is good, tablet Density Distribution is uniform, certain lubrication need to be added
Agent, to solve to occur the phenomenons such as mobility of particle poor, easy sticking during tabletting.Magnesium stearate, micropowder be compared in present invention test
Silica gel, Pulvis Talci, sodium lauryl sulphate, Mannitol do tabletting situation during lubricant, the results are shown in Table 3.
3 lubricant result on trial table of table
Knowable to the result of the test in table 3:Add magnesium stearate, sodium lauryl sulphate, Mannitol, mobility compared with
Good, and tabletting not sticking, the piece hardness for pressing out is suitable, and unilateral smooth and beautiful appearance adds micropowder silica gel, good fluidity, during tabletting
Not sticking, but the piece hardness for pressing out is low, adds Pulvis Talci, and mobility is bad, and sticking during tabletting, the piece hardness for pressing out are big.
Therefore the present invention selects magnesium stearate, sodium lauryl sulphate, Mannitol as lubricant.In order to adjust chewable tablet mouthfeel and
Based on the consideration to production cost, magnesium stearate, sodium lauryl sulphate, Mannitol three in present invention test, are also provide a comparison
Ratio, as a result shows：Magnesium stearate, sodium lauryl sulphate, the ratio of Mannitol three are 3:3:1 or 4:4:1 its mouthfeel
Reach optimal.
4. the selection of correctivess
Only the chewable tablet with good taste is just easily accepted, therefore, local flavor, mouthfeel are extremely important, and this is past
Realize toward by the selection of the correctivess such as sweeting agent, essence.Following sweeting agent is contrasted in present invention test：Sucrose, Lactose, Portugal
Grape sugar, stevioside, disodium glycyrrhizinate, aspartame, saccharin sodium, sodium cyclamate, mogroside, neotame, A Li
It is sweet, as a result show：Aspartame, mogroside, neotame in above-mentioned sweeting agent, in component, ratio is " sweeting agent 10-30
Use cooperatively with Mint Essence in the range of part ", taste flavor is good, and sugariness is moderate, no sense of discomfort, wherein aspartame mouthfeel
Most preferably.Therefore the present invention is sweeting agent from aspartame, mogroside, neotame, and specify that its addition is 10-30 parts.
2nd, the preparation method of composition for relieving asthenopia
Embodiment 1
The preparation method of the compositionss of enhancing immunity, comprises the steps：
T1：The preparation of flowers and fruits extract：Following raw material is weighed by weight：Camellia nitidissima Chi 20kg, fresh Fructus Mori 30kg；Take weighing
Good Camellia nitidissima Chi, plus 6 times of amount water, soak 30 minutes, supersound extraction 3 times, 30 minutes every time, and filtration obtains colored extracting solution；Take weighing
Good fresh Fructus Mori, clean, squeeze natural juice, filter, obtain fruit juice；Flower extracting solution is mixed with fruit juice, less than 80 DEG C concentrating under reduced pressure are obtained
When 60 DEG C, relative density is 1.20 fluid extract, and fluid extract is spray-dried, and controls baking temperature for 70 DEG C, obtains flowers and fruits and carry
Take thing；
T2：Sodium ascorbate, vitamin A, zinc gluconate, taurine, flowers and fruits extract, Spirulina powder, shallow lake are taken respectively
Powder, Mannitol, Microcrystalline Cellulose, PVP K-30, carboxymethyl starch sodium, sodium lauryl sulphate, neotame, crush, and cross 100 mesh
Sieve, it is standby；
T3. each supplementary material under T2 items is weighed by following weight portion respectively：Sodium ascorbate 50kg, vitamin A 0.1kg, Fructus Vitis viniferae
Saccharic acid zinc 10kg, taurine 10kg, flowers and fruits extract 10kg, Spirulina powder 10kg, starch 200kg, Mannitol 5kg, crystallite are fine
Dimension element 20kg, PVP K-30 5kg, carboxymethyl starch sodium 10kg, sodium lauryl sulphate 5kg, neotame 10kg, are passed with equivalent
Increasing method mix homogeneously, obtains mixed powder；
T4. the mixed powder under T3 items is taken, is stirred and is added 70-80% ethanol solution soft materials, crosses the granulation of 20 mesh sieves,
63 DEG C of dryings 4 hours, control moisture for 2-4%, cross 20 mesh sieve granulate, obtain granule；
T5. magnesium stearate 1kg, Mint Essence 0.1kg are weighed by following weight portion, is mixed homogeneously with granule under T4 items, pressed
Piece, obtains final product.
Embodiment 2
The preparation method of the compositionss of enhancing immunity, comprises the steps：
T1：The preparation of flowers and fruits extract：Following raw material is weighed by weight：Camellia nitidissima Chi 30kg, fresh Fructus Mori 45kg；Take weighing
Good Camellia nitidissima Chi, plus 8 times of amount water, soak 30 minutes, heating and refluxing extraction 2 times, 40 minutes every time, and filtration obtains colored extracting solution；Take
Load weighted fresh Fructus Mori, clean, squeeze natural juice, filter, obtain fruit juice；Flower extracting solution is mixed with fruit juice, less than 80 DEG C reduce pressure dense
Contracting, when obtaining 60 DEG C, relative density is 1.18 fluid extract, and fluid extract is spray-dried, and controls baking temperature for 80 DEG C, obtains
Flowers and fruits extract；
T2：Sodium ascorbate, vitamin A, zinc gluconate, taurine, flowers and fruits extract, Spirulina powder, shallow lake are taken respectively
Powder, Mannitol, Microcrystalline Cellulose, PVP K-30, carboxymethyl starch sodium, sodium lauryl sulphate, aspartame, crush, mistake
100 mesh sieves, it is standby；
T3. each supplementary material under T2 items is weighed by following weight portion respectively：Sodium ascorbate 120kg, vitamin A 0.5kg, Portugal
Grape saccharic acid zinc 20kg, taurine 20kg, flowers and fruits extract 15kg, Spirulina powder 15kg, starch 300kg, Mannitol 12kg, crystallite
Cellulose 40kg, PVP K-30 13kg, carboxymethyl starch sodium 30kg, sodium lauryl sulphate 12kg, aspartame 20kg,
With equal increments method mix homogeneously, mixed powder is obtained；
T4. the mixed powder under T3 items is taken, is stirred and is added 70-80% ethanol solution soft materials, crosses the granulation of 30 mesh sieves,
65 DEG C of dryings 4 hours, control moisture for 2-4%, cross 30 mesh sieve granulate, obtain granule；
T5. magnesium stearate 3kg, Mint Essence 0.3kg are weighed by following weight portion, is mixed homogeneously with granule under T4 items, pressed
Piece, obtains final product.
Embodiment 3
The preparation method of the compositionss of enhancing immunity, comprises the steps：
T1：The preparation of flowers and fruits extract：Following raw material is weighed by weight：Camellia nitidissima Chi 40kg, fresh Fructus Mori 6kg；Take weighing
Good Camellia nitidissima Chi, plus 10 times of amount water, soak 30 minutes, supersound extraction 3 times, 40 minutes every time, and filtration obtains colored extracting solution；Take title
Measured fresh Fructus Mori, clean, squeeze natural juice, filter, obtain fruit juice；Flower extracting solution is mixed with fruit juice, less than 80 DEG C concentrating under reduced pressure,
When obtaining 60 DEG C, relative density is 1.22 fluid extract, puts fluid extract into baking oven and is thermally dried, and controls baking temperature for 65
DEG C, obtain flowers and fruits extract；
T2：Sodium ascorbate, vitamin A, zinc gluconate, taurine, flowers and fruits extract, Spirulina powder, shallow lake are taken respectively
Powder, Mannitol, Microcrystalline Cellulose, PVP K-30, carboxymethyl starch sodium, sodium lauryl sulphate, mogroside, crush,
100 mesh sieves are crossed, it is standby；
T3. each supplementary material under T2 items is weighed by following weight portion respectively：Sodium ascorbate 200kg, retinol1 kg, Fructus Vitis viniferae
Saccharic acid zinc 30kg, taurine 30kg, flowers and fruits extract 20kg, Spirulina powder 20kg, starch 400kg, Mannitol 20kg, crystallite are fine
Dimension element 60kg, PVP K-30 20kg, carboxymethyl starch sodium 50kg, sodium lauryl sulphate 20kg, mogroside 30kg,
With equal increments method mix homogeneously, mixed powder is obtained；
T4. the mixed powder under T3 items is taken, is stirred and is added 70-80% ethanol solution soft materials, crosses the granulation of 14 mesh sieves,
60 DEG C of dryings 4 hours, control moisture for 2-4%, cross 14 mesh sieve granulate, obtain granule；
T5. magnesium stearate 5kg, Mint Essence 0.5kg are weighed by following weight portion, is mixed homogeneously with granule under T4 items, pressed
Piece, obtains final product.
3rd, stability test
Above-described embodiment 1-3 samples are packaged with aluminum-plastic composite membrane respectively, Accelerated stability test tank test is put:Temperature
Degree：40 ± 2 DEG C, relative humidity：75 ± 5%, accelerated test 3 months is the appearance character of acetonideexample 1-3 sample, mouthfeel, hard
Degree, friability, Contents of Main Components equistability high spot reviews index and sample determination results contrast when 0, have no significant change,
Taste flavor is also not changed in, illustrate that embodiment of the present invention 1-3 sample quality is relatively stable, can meet storage, transports, uses
Stability requirement.Result of the test is shown in Table 4.
The compositionss stability test result table of 4 enhancing immunity of table
Claims (12)
1. a kind of compositionss of enhancing immunity, it is characterised in that including the component of following weight portion：Sodium ascorbate 50-200
Part, vitamin A 0.1-1 parts, zinc gluconate 10-30 parts, taurine 10-30 parts, flowers and fruits extract 10-20 parts, Spirulina powder
10-20 parts；
The flowers and fruits extract is made up of the raw material of following weight portion：Camellia nitidissima Chi 20-40 parts, fresh Fructus Mori 30-60 parts.
2. compositionss of enhancing immunity as claimed in claim 1, it is characterised in that the preparation method of the flowers and fruits extract
For：
S1：Raw material is weighed by following weight portion：Camellia nitidissima Chi 20-40 parts, fresh Fructus Mori 30-60 parts；
S2：Load weighted Camellia nitidissima Chi is taken, plus 6-10 times is measured water, is soaked 30 minutes, is extracted 2-3 time, each 30-40 minutes, filtration,
Extracting solution must be spent；
S3：Load weighted fresh Fructus Mori are taken, is cleaned, is squeezed natural juice, filtered, obtain fruit juice；
S4：Flower extracting solution is mixed with fruit juice, less than 80 DEG C concentrating under reduced pressure, stream of the relative density for 1.18-1.22 when obtaining 60 DEG C
Extractum, fluid extract is dried, and is controlled baking temperature for 65-80 DEG C, is obtained flowers and fruits extract.
3. compositionss of enhancing immunity as claimed in claim 2, it is characterised in that extracting method is heating under step S2 item
Reflux, extract, supersound extraction.
4. compositionss of enhancing immunity as claimed in claim 2, it is characterised in that drying meanss are baking oven under step S4 item
Heat drying, spray drying.
5. compositionss of the enhancing immunity as described in arbitrary in claim 2-4, it is characterised in that plus adjuvant makes health care
The preparation allowed on food, food.
6. compositionss of enhancing immunity as claimed in claim 5, it is characterised in that the preparation is granule, pill, piece
Agent, capsule, oral liquid, syrup, beverage or tea-drinking.
7. compositionss of enhancing immunity as claimed in claim 6, it is characterised in that the tablet is chewable tablet.
8. a kind of compositionss of enhancing immunity as claimed in claim 7 make chewable tablet, it is characterised in that also including following
The component of weight portion：Starch 200-400 parts, Mannitol 5-20 part, Microcrystalline Cellulose 20-60 part, PVP K-30 5-20 parts,
Carboxymethyl starch sodium 10-50 parts, sodium lauryl sulphate 5-20 parts, magnesium stearate 1-5 part, sweeting agent 10-30 parts, Mint Essence
0.1-0.5 parts.
9. a kind of compositionss of enhancing immunity as claimed in claim 8 make the preparation method of chewable tablet, it is characterised in that
Comprise the following steps：
T1：The preparation of flowers and fruits extract：Following raw material is weighed by weight：Camellia nitidissima Chi 20-40 parts, fresh Fructus Mori 30-60 parts；Take title
Measured Camellia nitidissima Chi, plus 6-10 times measured water, is soaked 30 minutes, is extracted 2-3 time, each 30-40 minutes, filters, obtain colored extracting solution；
Load weighted fresh Fructus Mori are taken, is cleaned, is squeezed natural juice, filtered, obtain fruit juice；Flower extracting solution is mixed with fruit juice, less than 80 DEG C reduce pressure
Concentration, when obtaining 60 DEG C, relative density is the fluid extract of 1.18-1.22, and fluid extract is dried, and controls baking temperature for 65-80
DEG C, obtain flowers and fruits extract；
T2：Sodium ascorbate, vitamin A, zinc gluconate, taurine, flowers and fruits extract, Spirulina powder, starch, sweet is taken respectively
Dew alcohol, Microcrystalline Cellulose, PVP K-30, carboxymethyl starch sodium, sodium lauryl sulphate, sweeting agent, crush, and cross 100 mesh sieves,
It is standby；
T3. each supplementary material under T1 items is weighed by formula ratio respectively, with equal increments method mix homogeneously, obtain mixed powder；
T4. the mixed powder under T3 items is taken, is stirred and is added 70-80% ethanol solution soft materials, granulation of sieving, be dried 4 little
When, it is 2-4% to control moisture, and sieve granulate, obtains granule；
T5. magnesium stearate, Mint Essence are weighed by formula ratio, is mixed homogeneously with granule under S3 items, tabletting is obtained final product.
10. the compositionss of enhancing immunity as claimed in claim 9 make the preparation method of chewable tablet, it is characterised in that step
Under rapid T4 items, dry temperature is 60-65 DEG C.
The compositionss of 11. enhancing immunity as claimed in claim 9 make the preparation method of chewable tablet, it is characterised in that step
Screen cloth under rapid T4 items used by described sifting step is 14-30 mesh.
Chewable tablet made by the compositionss of 12. enhancing immunity as described in arbitrary in claim 8-9, it is characterised in that institute
Sweeting agent is stated for aspartame, neotame, mogroside.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610964502.5A CN106562438A (en) | 2016-10-28 | 2016-10-28 | Immunity enhancement composition and preparation method thereof |
| PCT/CN2017/108403 WO2018077276A1 (en) | 2016-10-28 | 2017-10-30 | Immunity-enhancing composition and preparation method therefor |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107184579A (en) * | 2017-06-01 | 2017-09-22 | 防城港圣保堂制药有限公司 | A kind of ion VC granules and preparation method thereof |
| WO2018077276A1 (en) * | 2016-10-28 | 2018-05-03 | 广西圣保堂健康产业股份有限公司 | Immunity-enhancing composition and preparation method therefor |
| CN114190546A (en) * | 2021-11-24 | 2022-03-18 | 重庆万源佳药业有限公司 | Microecological extract capable of improving immunity and preparation method thereof |
| CN116138456A (en) * | 2022-09-28 | 2023-05-23 | 青岛固德励健生物技术有限公司 | Spirulina tablet |
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| CN110179128A (en) * | 2019-07-15 | 2019-08-30 | 黑龙江省科学院大庆分院 | Compound enteric-coated capsule of a kind of Chinese fiber crops seed polypeptide and preparation method thereof |
| CN111134319A (en) * | 2019-10-16 | 2020-05-12 | 上海海聚生物科技有限公司 | Biological health food containing spirulina and fructus Rosae Normalis, and its preparation method |
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| CN113499348A (en) * | 2021-07-05 | 2021-10-15 | 江西国妙堂生物医药科技有限公司 | Bear gall sugar-free buccal tablet and preparation method and application thereof |
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| WO2018077276A1 (en) * | 2016-10-28 | 2018-05-03 | 广西圣保堂健康产业股份有限公司 | Immunity-enhancing composition and preparation method therefor |
| CN107184579A (en) * | 2017-06-01 | 2017-09-22 | 防城港圣保堂制药有限公司 | A kind of ion VC granules and preparation method thereof |
| CN114190546A (en) * | 2021-11-24 | 2022-03-18 | 重庆万源佳药业有限公司 | Microecological extract capable of improving immunity and preparation method thereof |
| CN116138456A (en) * | 2022-09-28 | 2023-05-23 | 青岛固德励健生物技术有限公司 | Spirulina tablet |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2018077276A1 (en) | 2018-05-03 |
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