CN113017081A - Ganoderma lucidum spore powder tablet and preparation method thereof - Google Patents
Ganoderma lucidum spore powder tablet and preparation method thereof Download PDFInfo
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- CN113017081A CN113017081A CN202110267019.2A CN202110267019A CN113017081A CN 113017081 A CN113017081 A CN 113017081A CN 202110267019 A CN202110267019 A CN 202110267019A CN 113017081 A CN113017081 A CN 113017081A
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/035—Organic compounds containing oxygen as heteroatom
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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- A23L29/04—Fatty acids or derivatives
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- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
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- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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Abstract
The invention discloses a ganoderma lucidum spore powder tablet and a preparation method thereof, the tablet comprises 10-17 parts of ganoderma lucidum spore powder, 7-13 parts of ganoderma lucidum polysaccharide or dendrobium officinale polysaccharide, 6-10 parts of microcrystalline cellulose, 8-10 parts of lactose, 4-5 parts of white granulated sugar, 3-10 parts of maltodextrin, 0.5-1 part of magnesium stearate, 50-60% ethanol solution or 5-7 parts of 15-20% glutinous rice flour slurry; mixing part of the raw materials according to the principle of equivalent incremental mixing, adding maltodextrin and binder to make into soft material, granulating, drying, grading, adding magnesium stearate, mixing, and tabletting. According to the invention, through the optimization of the formula and the optimization of the process, the prepared ganoderma lucidum spore powder tablet has the advantages of uniform color, smooth and complete surface, good hardness and friability, good quality consistency of the obtained tablet product, high content of ganoderma lucidum spore powder in the product, and improved sensory property and palatability of the tablet.
Description
Technical Field
The invention belongs to the technical field of health-care food and preparation thereof, and particularly relates to a ganoderma lucidum spore powder tablet and a preparation method thereof.
Background
Ganoderma (Ganoderma lucidum) belongs to Polyporaceae of Basidiomycetes of Basidiomycota, is a traditional medicinal fungus, and has effects of nourishing, strengthening body constitution, strengthening body resistance, and prolonging life. The seeds (called spores in biology, the diameter is 5-8 μm) released by the ganoderma lucidum in the growth and maturation period, the collected ganoderma lucidum spores are powdery, about 1kg of spore powder can be collected by about 1000kg of ganoderma lucidum sporocarp, and the ganoderma lucidum spore powder is rare and precious. The ganoderma lucidum spore contains specific bioactive components such as polysaccharide peptide, triterpene, nucleoside, protein, enzyme and selenium element which are more abundant than ganoderma lucidum, and has the medicinal values of enhancing immunity, inhibiting tumor, protecting liver, reducing blood sugar, resisting oxidation and the like. Therefore, the ganoderma lucidum spore powder becomes a hot spot of the current research and is widely used as a raw material of health food.
The forms of the related products of the ganoderma lucidum spore powder in the current market mainly exist in the forms of powder, granules, capsules and the like, and the forms have the following defects: the powdery product has poor oral palatability, and the capsule has poor dispersibility and absorbability in vivo, and the capsule shell is mainly made of gelatin material, so that long-term eating has certain influence on human body; the powder and the granules are easy to absorb moisture and denature; the spore powder has poor fluidity and high oil content, is easy to adhere to the surface of a container or a package, and influences the quality and the edibility of the product.
Therefore, the utilization rate of the ganoderma lucidum spore powder can be effectively improved by preparing the ganoderma lucidum spore powder into tablets, and the ganoderma lucidum spore powder is convenient to eat and carry. However, the ganoderma lucidum spore powder is rich in grease and cellulose, has large surface tension and poor fluidity and compressibility, and is not easy to be tabletted and molded. In addition, the ganoderma lucidum spore powder is bitter in taste, easy to oxidize and easy to absorb moisture, and the problems of sticking of the spore powder to tablets, non-forming, non-smooth surface of the product and the like are easy to occur in the tabletting process, so that the key problem of the existing tablet preparation of the ganoderma lucidum spore powder is how to optimize the ganoderma lucidum spore powder tabletting technology to obtain a tablet product with stable product quality and high ganoderma lucidum spore powder content.
The early-stage research of an inventor team shows that in the spore powder tablet prepared by adopting a spore powder wet granulation and tabletting technology, the key technology has the following aspects: selecting and adding a filling agent, a binding agent and the like in raw materials of the spore powder tablet, processing and mixing the raw materials in a granulation process, and granulating, drying, finishing and the like in a tabletting process.
The invention adopts wet granulation and tabletting, and aims to obtain required ganoderma spore tablets by changing the flowability and compressibility of ganoderma spore powder, selecting a filling agent, an adhesive and the like, optimizing a formula and combining an optimized granulation and tabletting process.
Disclosure of Invention
In order to achieve the above object, according to a first aspect of the present invention, the present invention provides the following:
a ganoderma lucidum spore powder tablet comprises the following raw materials in parts by weight: 10-17 parts of ganoderma lucidum spore powder, 7-13 parts of filler, 6-10 parts of microcrystalline cellulose, 8-10 parts of lactose, 4-5 parts of white granulated sugar, 3-10 parts of maltodextrin, 0.5-1 part of magnesium stearate and 5-7 parts of adhesive, wherein the filler is ganoderma lucidum polysaccharide or dendrobium officinale polysaccharide, and the adhesive is 50-60% of ethanol solution or 15-20% of glutinous rice flour slurry.
Further, the ganoderma lucidum spore powder tablet comprises the following raw materials in parts by weight: 12 parts of ganoderma lucidum spore powder, 10 parts of filler, 8 parts of microcrystalline cellulose, 9 parts of lactose, 5 parts of white granulated sugar, 5.5 parts of maltodextrin, 0.5 part of magnesium stearate and 6 parts of adhesive, wherein the filler is ganoderma lucidum polysaccharide or dendrobium officinale polysaccharide, and the adhesive is 50-60% of ethanol solution or 15-20% of glutinous rice flour slurry.
Further, the binder is 60% ethanol solution.
According to a second aspect of the invention, the invention provides the following:
a preparation method of the ganoderma lucidum spore powder tablet with the formula comprises the following steps: (1) mixing: weighing Ganoderma spore powder, Ganoderma polysaccharide or Dendrobium officinale polysaccharide, microcrystalline cellulose, lactose and white sugar powder according to equivalent incremental mixing principle, and mixing to obtain total mixed powder; (2) preparing a soft material: mixing maltodextrin with the total mixed powder, and adding adhesive to obtain soft material; (3) and (3) granulation: making the soft material into wet granules by a 16-mesh screen; (4) and (3) drying: drying the wet granules at 60-70 deg.C to obtain dry granules; (5) straightening: sieving the dry particles with a 16-mesh sieve again to obtain a particle material to be mixed; (6) mixing magnesium stearate with the granules to be mixed uniformly to obtain a total mixed granule material; (7) tabletting: adjusting tablet weight and pressure, and tabletting the total mixed granule material in a tabletting machine to obtain Ganoderma spore powder tablet.
Further, in the step (1), the raw materials are ground and sieved before mixing, and the mesh number of the sieved raw materials is 80-100 meshes. Because different raw and auxiliary materials have different powder properties and different particle sizes, the materials with uniform particle size and uniform mixing are obtained by adopting grinding and sieving modes.
Further, in the step (1), the raw materials are ground and sieved before being mixed, and the mesh number of the sieved raw materials is 80 meshes.
Further, in the step (2), the moisture content of the prepared soft material is 7%. If the viscosity of the soft material is too high, granulation is not easy to occur; if the viscosity is too low, the granules are in powder form and do not meet the requirements.
Further, in the step (4), the moisture content of the dry granules is 4% or less. In the step (4), the drying temperature is not easy to be too high, otherwise, the nutritional ingredients in the ganoderma lucidum spore powder can be damaged, and the moisture content of the dried material needs to be proper.
Further, in the step (6), an SBH-200 series three-dimensional mixer is adopted, the rotating speed is less than 800r/min, the feeding amount is 50kg, and the mixing is carried out for 30 min. The timing and mixing mode of magnesium stearate mixing greatly affect the shape of the final tablet product, such as appearance, and need to be strictly controlled.
Further, in the step (7), a ZP W23D rotary tablet press is adopted, the compression pressure is less than 1KN, the speed is 6.5-7.0r/min, and the feeding amount is 35 g.
In summary, due to the adoption of the technical scheme, the invention has the beneficial effects that:
(1) according to the invention, through optimization of the formula and optimization of the process, the flowability and compressibility of the material are increased, the adsorption and storage capacity of fine powder are reduced to reduce the loosening and cracking of the tablet, and powder layering and fine powder flying are avoided. The prepared ganoderma lucidum spore powder tablet has the advantages of uniform color, smooth and complete surface, good hardness and friability, good quality consistency of the obtained tablet product, high content of ganoderma lucidum spore powder in the product, and improved sensory property and palatability of the tablet.
(2) The invention takes the fluidity of materials after granulation, the appearance of tablets, hardness, friability, disintegration time limit and tablet weight difference as detection indexes, explores and selects proper filling agents (namely ganoderma lucidum polysaccharide or dendrobium officinale polysaccharide) and adhesives (namely 50-60% ethanol solution or 15-20% glutinous rice flour slurry), and explores and determines proper adding amounts of the filling agents and the adhesives, wherein the adding amount of the filling agents is 7-13 parts by weight, and the adding amount of the adhesives is 5-7 parts by weight.
The adhesive has the function of bonding and molding material particles in the tabletting process, and is beneficial to tabletting. The inventor researches that the type and the addition amount of the binding agent have a remarkable influence on the flowability of the mixture before compression and the appearance and hardness of the tablets obtained by compression and influence on the tablet weight difference of the tablets obtained by compression. Proved by verification, the best adhesive is 60% ethanol solution, and the best addition amount is 5-7 parts by weight.
The filler can influence the nutrition of the ganoderma lucidum spore powder tablet, and also needs to meet the requirements on material fluidity, appearance, hardness, friability, disintegration time and tablet weight difference of the prepared tablet. Proved by verification, the optimal filler is ganoderma lucidum polysaccharide or dendrobium officinale polysaccharide, and the optimal addition amount is 10 parts by weight.
(3) The invention also explores and researches the preparation process of the ganoderma lucidum spore powder tablet, and the inventor discovers that the mixing sequence and the mixing mode of the raw materials in the granulation process influence the flowability of the granulated material and the appearance, hardness, friability and tablet weight difference of the prepared tablet. Specifically, the invention adopts an equivalent incremental mixing mode, firstly, ganoderma lucidum spore powder, ganoderma lucidum polysaccharide or dendrobium officinale polysaccharide, microcrystalline cellulose, lactose and white granulated sugar powder are mixed, maltodextrin is added when a soft material is prepared, and finally, magnesium stearate is added before tabletting, so that the appearance surface of the finally obtained tablet is smooth and complete.
(4) The process steps of granulation, drying, granulation and incorporation of magnesium stearate of the present invention affect the appearance, hardness, friability and tablet weight variation of the tablets produced. Firstly, through the steps of granulating, drying and grading, the particle size of the obtained mixed material is more uniform, the prepared tablet is smoother and more uniform, and the sensory property and the palatability of the tablet are correspondingly improved. And drying and granulating after wet granulation, adding a small amount of magnesium stearate for tabletting, wherein the magnesium stearate is used as a lubricant, an anticaking agent and a retention aid to further enhance the flowability and compressibility of the prepared granules, so that the prepared tablets are smoother, uniform in color and luster, better in hardness and small in tablet weight difference.
Additional aspects and advantages of the invention will be set forth in part in the description which follows and, in part, will be obvious from the description, or may be learned by practice of the invention.
Drawings
FIG. 1 is a flow chart of the preparation process of the ganoderma lucidum spore powder tablet provided by the invention.
Detailed Description
The present invention is further described with reference to the following examples, which are not intended to limit the invention, but rather, to illustrate that the various embodiments described below or various features may be combined arbitrarily to form new embodiments without conflict. The operation methods mentioned in the following examples are conventional methods unless otherwise specified; the materials, equipment, etc. used may be obtained by purchase or other means (for example, preparation methods well known to those skilled in the art) unless otherwise specified.
The invention relates to a health food which is prepared by taking selenium-rich ganoderma lucidum spore powder, ganoderma lucidum polysaccharide or dendrobium officinale polysaccharide extract, lactose, microcrystalline cellulose, white granulated sugar and maltodextrin as raw materials and has the function of enhancing immunity. The selenium-rich ganoderma spore powder is bitter in taste and easy to oxidize, and the powdery product has poor palatability, is prepared into tablets after formula optimization, has reduced bitterness and oxidation rate, effectively improves the utilization rate of the ganoderma spore powder product, and is convenient to eat and carry. The invention solves the problems of sticking, non-forming, non-smooth surface of the product and the like of the spore powder in the tabletting process, overcomes the key technology of the ganoderma lucidum spore powder tabletting and obtains the tablet product with high ganoderma lucidum spore powder content. The raw materials selected by the product are all raw materials for health food, and the production process meets the requirements related to food sanitation. Therefore, the product is a safe health food and can be eaten for a long time.
On the basis of a laboratory early-stage formula, the invention takes the flowability, the appearance, the hardness, the friability, the disintegration time limit and the tablet weight difference of a granulated material as detection indexes, screens a filling agent, a binding agent and the like, and optimizes the formula and the preparation process of the ganoderma spore powder tablet.
Material fluidity: the angle of repose of the material was measured and used to evaluate the flowability of the material. When the angle of repose is more than 45 degrees, the fluidity is poor; when the angle of repose is less than 40 degrees, the fluidity is good; when the angle of repose is less than 35 °, the fluidity is excellent.
Appearance of the tablet: visual observation was used to directly evaluate the tablets. The tablet surface should be uniform in color, smooth, and free of mottle.
Hardness: referring to the method of the Wenxing et al, the prepared tablet is naturally dropped on a 2cm thick pinewood plate from a height of 1 m, and the fragmentation rate is not more than 30%.
Friability: the friability of tablets is measured by referring to the examination method of the friability of tablets of the Chinese pharmacopoeia 2015 year edition 0923.
Disintegration time limit: the disintegration time limit is measured by referring to the examination method of 0921 in the year version of the Chinese pharmacopoeia 2015.
Difference in tablet weight: weighing 20 Ganoderma spore powder tablets by weighing, accurately weighing the total weight and each tablet weight, and calculating the average tablet weight. The weight difference of the tablets is not more than 2 tablets, and 1 time of the limit of 1 tablet is not exceeded. According to the regulation of Chinese pharmacopoeia, the weight difference of tablets with the average weight of more than 0.3g is +/-5%.
Fig. 1 shows a schematic flow chart of a process for preparing a ganoderma lucidum spore powder tablet of the invention. Wherein, in the schematic preparation flow chart, the filling agent is ganoderma lucidum polysaccharide, and the adhesive is added when preparing the soft material.
Example 1
The formula and the preparation process are adopted to prepare the ganoderma lucidum spore powder tablet, and the details are as follows.
The raw materials for preparing the ganoderma lucidum spore powder tablet and the parts by weight thereof shown in table 1 are used for preparing the ganoderma lucidum spore powder tablet according to the following steps:
(1) mixing: weighing Ganoderma spore powder, Ganoderma polysaccharide or Dendrobium officinale polysaccharide, microcrystalline cellulose, lactose and white sugar powder according to formula shown in Table 1 and equal amount increasing mixing principle, and mixing to obtain total mixed powder;
(2) preparing a soft material: mixing maltodextrin with the total mixed powder, and adding appropriate amount of binder to obtain soft material;
(3) and (3) granulation: making the soft material into wet granules by a 16-mesh screen;
(4) and (3) drying: drying the wet granules at 60-70 deg.C to obtain dry granules;
(5) straightening: sieving the dry particles with a 16-mesh sieve again to obtain a particle material to be mixed;
(6) mixing magnesium stearate with the granules to be mixed uniformly to obtain a total mixed granule material;
(7) tabletting: adjusting tablet weight and pressure, and tabletting the total mixed granule material in a tabletting machine to obtain Ganoderma spore powder tablet.
TABLE 1 raw material formulation of Ganoderma lucidum spore powder tablet
The adhesive shown in table 1 is 50-60% ethanol solution or 15-20% glutinous rice flour slurry, wherein the adhesive in the formula of samples 1-3 is 60% ethanol solution, and the adhesive in the formula of samples 4-5 is 20% glutinous rice flour slurry.
Furthermore, because different raw and auxiliary materials have different powder properties and different particle sizes, the materials with uniform particle size and uniform mixing are obtained by adopting grinding and sieving modes. Therefore, in the step (1), the raw materials are ground and sieved before mixing, the sieved mesh number is 80-100 meshes, and more preferably, the raw materials in the step (1) are sieved by a 80-mesh screen before mixing.
Further, in the step (2), the moisture content of the prepared soft material is 7%. If the viscosity of the soft material is too high, granulation is not easy to occur; if the viscosity is too low, the granules are in powder form and do not meet the requirements.
Furthermore, in the step (4), the drying temperature is not easy to be too high, otherwise, the nutritional ingredients in the ganoderma lucidum spore powder can be damaged. And drying until the moisture content in the material is proper, wherein the moisture content of the dried particles is below 4 percent after drying.
Further, in the step (6), an SBH-200 series three-dimensional mixer is adopted, the rotating speed is less than 800r/min, the feeding amount is 50kg, and the mixing is carried out for 30 min.
Further, in the step (7), a ZP W23D rotary tablet press is adopted, the compression pressure is less than 1KN, the speed is 6.5-7.0r/min, and the feeding amount is 35 g.
Example 2
The 5 samples prepared above were analyzed using the granulated material flowability, tablet appearance, hardness, friability, disintegration time, and tablet weight difference as detection indices, and the results are shown in table 2.
TABLE 2 analysis of the results of the Ganoderma spore powder tablets
Example 3
The preparation process verification is carried out according to the formula of the sample 3, namely, the corresponding raw and auxiliary materials are respectively weighed according to the formula proportion of the sample 3, and are ground, mixed uniformly, sieved, made into a soft material by using a 60% ethanol solution as a binding agent, then sieved by a 16-mesh sample sieve for granulation, dried at the temperature of 60 ℃, granulated by the 16-mesh sample sieve, and tableted to obtain a finished product. Wherein the amount of raw materials (excluding binder) was 25g in total, and 50 tablets were prepared, and the theoretical weight of the tablets was 0.5 g/tablet, and 3 batches were prepared in total.
The ganoderma lucidum spore powder tablets prepared by 3 batches under the condition are dark brown, uniform in color and smooth and complete in surface. The verification test results of the preparation process of the ganoderma lucidum spore powder tablet are shown in table 3, and the weight difference of the prepared ganoderma lucidum spore powder tablet is shown in table 4.
TABLE 3 verification test of preparation process of Ganoderma spore powder tablet
| Batches of | 1 | 2 | 3 |
| Formula amount (g) | 25 | 25 | 25 |
| Theoretical number (sheet) | 50 | 50 | 50 |
| Actual number (sheet) | 46 | 47 | 45 |
| Yield (%) | 92 | 94 | 90 |
TABLE 4 Ganoderma spore powder tablet weights
As can be seen from Table 3, the yield of tablets produced by the process reached at least 90%. As can be seen from Table 4, the tablet weights of the obtained tablets all meet the requirements.
Example 4
The experimental results are compared with the selection of the filling agent and the binding agent of the ganoderma lucidum spore powder tablet.
Selection of fillers
Because the ganoderma lucidum spore powder is rich in grease and fiber, has small mass, light weight and high toughness, is difficult to be pressed into tablets, and needs to be added with a filling agent. Firstly, from the perspective of nutrition and health, a series of natural substances are selected as main filling agents for screening, wherein the natural substances mainly comprise ganoderma lucidum fruiting body powder, ganoderma lucidum polysaccharide, mushroom powder, lycium barbarum polysaccharide, dendrobium officinale polysaccharide, konjac powder and the like, and screening is carried out on the basis of a formula in the early stage of a laboratory by taking the flowability of materials after granulation, the appearance, hardness, friability, disintegration time limit and tablet weight difference of tablets as detection indexes. Table 5 shows the results of the tests with different fillers.
TABLE 5 Filler screening results
As can be seen from Table 5, the selected filler can meet the requirements on material fluidity, but only the ganoderan and the dendrobium officinale polysaccharide meet the requirements by combining the indexes of appearance, hardness, friability, disintegration time and tablet weight difference of the tablets. Therefore, the filler of the invention is ganoderma lucidum polysaccharide or dendrobium officinale polysaccharide. In addition, in view of maximizing the use of ganoderma lucidum, ganoderma lucidum polysaccharide is preferred as a main filler.
4.2 selection of Binders
The adhesive has the function of bonding and molding material particles in the tabletting process, and is beneficial to tabletting. Because the ganoderma lucidum spore powder is rich in grease, the viscosity of the mixed material is not high, and the screening of a proper adhesive is particularly important. The invention selects ethanol solution (50%, 60%, 70%), glutinous rice flour slurry (15%, 20%, 25%) and 10% gelatin solution as adhesive, and selects according to the fluidity of granulated material, appearance, hardness, friability, disintegration time limit and weight difference of tablets as detection indexes based on the formula in the early stage of a laboratory. Table 6 shows the screening results for different binders.
TABLE 6 Binder screening results
"- -" indicates no measurement.
As can be seen from Table 6, the material made with the 10% gelatin solution generally had a flowability and could not be tabletted, so gelatin was not considered as a binder; glutinous rice flour slurries with different concentrations are used as a binding agent, the material flowability and the appearance of the tablet are deteriorated with the increase of the concentration, the hardness of the prepared tablet is poor, but the 20 percent glutinous rice flour slurry basically meets the requirement; ethanol solutions with different concentrations are used as the adhesive, the material fluidity, the tablet appearance and the hardness gradually meet the requirements, the tablet weight difference is in the required range, and according to the test result, 60 percent ethanol solution is selected as the optimal adhesive.
Example 5
Optimization and comparison experiments of the preparation process of the ganoderma lucidum spore powder tablet.
Preparation processes 1 to 4, which are compared with the preparation process shown in example 1, were set and designated as comparative examples 1 to 4.
Comparative example 1 differs from the preparation process shown in example 1 in that: the mixing step of the step (1) does not adopt the principle of equivalent incremental mixing, and other steps are the same.
Comparative example 2 differs from example 1 in that: maltodextrin and magnesium stearate were added in the mixing step of step (1), and the other steps were the same.
Comparative example 3 differs from example 1 in that: does not comprise a granulation step, namely drying directly after preparing a soft material, and other steps are the same.
Comparative example 4 differs from example 1 in that: the mesh number of the sieve for granulation and size stabilization is 25 meshes.
The flowability of the granulated material and the appearance, hardness, friability, disintegration time and tablet weight difference of the tablets of comparative examples 1 to 4 and example 1, sample 3 were compared, and the results are shown in table 7.
TABLE 7 comparative results for tablets
From the results in table 7, it is understood that the order of mixing the raw materials in the granulation process, the mixing manner, and the operation steps of granulating, drying, sizing, and mixing magnesium stearate affect the flowability after granulation and the appearance, hardness, friability, and tablet weight difference of the tablets produced.
The results of comparing comparative example 1 with example 1 show that the flowability and compressibility of the granulated material are poor when the raw materials are not mixed by the principle of equal incremental mixing, because the raw materials are not easily mixed uniformly due to their high viscosity. And the tablet obtained by pressing has unsmooth surface, more crushed powder and substandard hardness.
The results of comparing comparative example 2 with example 1 show that the addition of maltodextrin and magnesium stearate in the mixing step of step (1) affects the flowability of the granulated material, and the tablets obtained by compression have a non-smooth surface, a lot of crumbling and a serious dusting.
The comparison of comparative example 3 with example 1 shows that drying directly after soft material making results in uneven granulation of the compressed tablet, resulting in an uneven surface and large variation in tablet weight of the final tablet product.
The comparison result of the comparative example 4 and the example 1 shows that the particle size of the screen during granulation and size stabilization influences the performance of the final tablet product, the smaller the particle size of the screen is, the better the particle size of the screen is, the smaller the particle size of the screen can cause the final tablet product to be more crushed, the hardness does not reach the standard, the weight loss reduction amount is larger, and the tablet weight difference is larger.
While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
Claims (10)
1. The ganoderma lucidum spore powder tablet is characterized by comprising the following raw materials in parts by weight:
10-17 parts of ganoderma lucidum spore powder,
7-13 parts of a filler,
6-10 parts of microcrystalline cellulose,
8-10 parts of lactose,
4-5 parts of white granulated sugar,
3-10 parts of maltodextrin,
0.5-1 part of magnesium stearate,
5-7 parts of an adhesive agent,
the filler is ganoderma lucidum polysaccharide or dendrobium officinale polysaccharide, and the adhesive is 50-60% of ethanol solution or 15-20% of glutinous rice flour slurry.
2. The ganoderma lucidum spore powder tablet as claimed in claim 1, which is characterized by comprising the following raw materials in parts by weight:
12 portions of ganoderma lucidum spore powder,
10 parts of a filler,
8 portions of microcrystalline cellulose,
9 parts of lactose,
5 parts of white granulated sugar,
5.5 parts of maltodextrin,
0.5 part of magnesium stearate,
6 parts of an adhesive agent, namely 6 parts of,
the filler is ganoderma lucidum polysaccharide or dendrobium officinale polysaccharide, and the adhesive is 50-60% of ethanol solution or 15-20% of glutinous rice flour slurry.
3. The ganoderma lucidum spore powder tablet of claim 1, wherein the binding agent is a 60% ethanol solution.
4. A method for preparing the ganoderma lucidum spore powder tablet according to any one of claims 1 to 3, comprising the steps of:
(1) mixing: weighing Ganoderma spore powder, Ganoderma polysaccharide or Dendrobium officinale polysaccharide, microcrystalline cellulose, lactose and white sugar powder according to equivalent incremental mixing principle, and mixing to obtain total mixed powder;
(2) preparing a soft material: mixing maltodextrin with the total mixed powder, and adding adhesive to obtain soft material;
(3) and (3) granulation: making the soft material into wet granules by a 16-mesh screen;
(4) and (3) drying: drying the wet granules at 60-70 deg.C to obtain dry granules;
(5) straightening: sieving the dry particles with a 16-mesh sieve again to obtain a particle material to be mixed;
(6) mixing magnesium stearate with the granules to be mixed uniformly to obtain a total mixed granule material;
(7) tabletting: adjusting tablet weight and pressure, and tabletting the total mixed granule material in a tabletting machine to obtain Ganoderma spore powder tablet.
5. The method for preparing the ganoderma lucidum spore powder tablet according to claim 1, wherein in the step (1), the raw materials are ground and sieved before mixing, and the mesh number of the sieving is 80-100 meshes.
6. The method for preparing the ganoderma lucidum spore powder tablet according to claim 5, wherein in the step (1), the raw materials are ground and sieved before mixing, and the mesh number of the sieving is 80 meshes.
7. The method for preparing ganoderma lucidum spore powder tablets according to claim 1, wherein the water content of the soft material prepared in the step (2) is 7%.
8. The method for preparing a tablet of Ganoderma lucidum spore powder according to claim 1, wherein in the step (4), the moisture content of the dry granules is 4% or less.
9. The method for preparing ganoderma lucidum spore powder tablets according to claim 1, wherein in the step (6), an SBH-200 series three-dimensional mixer is adopted, the rotating speed is less than 800r/min, the feeding amount is 50kg, and the mixing is carried out for 30 min.
10. The method for preparing Ganoderma lucidum spore powder tablet according to claim 1, wherein in the step (7), ZP W23D rotary tablet press is adopted, the compression pressure is less than 1KN, the speed is 6.5-7.0r/min, and the feeding amount is 35 g.
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Application publication date: 20210625 |