CN114431477A - Probiotic tabletting preparation and preparation method and application thereof - Google Patents
Probiotic tabletting preparation and preparation method and application thereof Download PDFInfo
- Publication number
- CN114431477A CN114431477A CN202210189324.9A CN202210189324A CN114431477A CN 114431477 A CN114431477 A CN 114431477A CN 202210189324 A CN202210189324 A CN 202210189324A CN 114431477 A CN114431477 A CN 114431477A
- Authority
- CN
- China
- Prior art keywords
- parts
- probiotic
- tabletting
- preparation
- corn starch
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000006041 probiotic Substances 0.000 title claims abstract description 63
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 63
- 230000000529 probiotic effect Effects 0.000 title claims abstract description 58
- 238000002360 preparation method Methods 0.000 title claims abstract description 54
- 229920002261 Corn starch Polymers 0.000 claims abstract description 29
- 239000008120 corn starch Substances 0.000 claims abstract description 29
- 241000894006 Bacteria Species 0.000 claims abstract description 28
- 239000000843 powder Substances 0.000 claims abstract description 26
- 239000000463 material Substances 0.000 claims abstract description 23
- 239000000853 adhesive Substances 0.000 claims abstract description 21
- 230000001070 adhesive effect Effects 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 8
- 239000002245 particle Substances 0.000 claims abstract description 5
- 239000000203 mixture Substances 0.000 claims description 25
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 22
- 238000003756 stirring Methods 0.000 claims description 20
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 20
- 238000009472 formulation Methods 0.000 claims description 16
- 238000002156 mixing Methods 0.000 claims description 16
- 102000011632 Caseins Human genes 0.000 claims description 15
- 108010076119 Caseins Proteins 0.000 claims description 15
- 239000008187 granular material Substances 0.000 claims description 15
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 15
- 229940080237 sodium caseinate Drugs 0.000 claims description 15
- 235000013312 flour Nutrition 0.000 claims description 12
- 235000007164 Oryza sativa Nutrition 0.000 claims description 11
- 235000019359 magnesium stearate Nutrition 0.000 claims description 11
- 235000009566 rice Nutrition 0.000 claims description 11
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 10
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims description 10
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 10
- SHZGCJCMOBCMKK-PQMKYFCFSA-N L-Fucose Natural products C[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O SHZGCJCMOBCMKK-PQMKYFCFSA-N 0.000 claims description 10
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims description 10
- PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 claims description 10
- 229930195725 Mannitol Natural products 0.000 claims description 10
- GDVKFRBCXAPAQJ-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide Chemical group [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O GDVKFRBCXAPAQJ-UHFFFAOYSA-A 0.000 claims description 10
- 239000008103 glucose Substances 0.000 claims description 10
- 229960001545 hydrotalcite Drugs 0.000 claims description 10
- 229910001701 hydrotalcite Inorganic materials 0.000 claims description 10
- 239000000594 mannitol Substances 0.000 claims description 10
- 235000010355 mannitol Nutrition 0.000 claims description 10
- 239000002002 slurry Substances 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 9
- 239000003223 protective agent Substances 0.000 claims description 8
- 102000008186 Collagen Human genes 0.000 claims description 7
- 108010035532 Collagen Proteins 0.000 claims description 7
- 229920001436 collagen Polymers 0.000 claims description 7
- 239000007891 compressed tablet Substances 0.000 claims description 7
- PNNNRSAQSRJVSB-KCDKBNATSA-N aldehydo-L-fucose Chemical compound C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-KCDKBNATSA-N 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 claims description 5
- 239000007788 liquid Substances 0.000 claims description 5
- 239000008213 purified water Substances 0.000 claims description 5
- 239000007779 soft material Substances 0.000 claims description 5
- 230000001580 bacterial effect Effects 0.000 claims description 3
- 230000036541 health Effects 0.000 claims description 3
- 239000008188 pellet Substances 0.000 claims description 3
- 238000001694 spray drying Methods 0.000 claims description 3
- 230000004913 activation Effects 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 239000011230 binding agent Substances 0.000 claims description 2
- 210000000988 bone and bone Anatomy 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 240000007594 Oryza sativa Species 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000009286 beneficial effect Effects 0.000 abstract description 5
- 244000005700 microbiome Species 0.000 abstract description 4
- 238000004321 preservation Methods 0.000 abstract description 4
- 230000008569 process Effects 0.000 abstract description 4
- 238000005336 cracking Methods 0.000 abstract description 3
- 239000012535 impurity Substances 0.000 abstract description 3
- 239000003826 tablet Substances 0.000 description 36
- 230000000052 comparative effect Effects 0.000 description 13
- 241000209094 Oryza Species 0.000 description 10
- 238000004519 manufacturing process Methods 0.000 description 8
- 238000001514 detection method Methods 0.000 description 7
- 238000012360 testing method Methods 0.000 description 6
- 235000009508 confectionery Nutrition 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- 210000001035 gastrointestinal tract Anatomy 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 230000002708 enhancing effect Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 239000008107 starch Substances 0.000 description 3
- 235000019698 starch Nutrition 0.000 description 3
- 240000001046 Lactobacillus acidophilus Species 0.000 description 2
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 2
- 241000888288 Streptococcus salivarius K12 Species 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 238000005054 agglomeration Methods 0.000 description 2
- 230000002776 aggregation Effects 0.000 description 2
- 238000007865 diluting Methods 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- 239000004386 Erythritol Substances 0.000 description 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- HEBKCHPVOIAQTA-NGQZWQHPSA-N d-xylitol Chemical compound OC[C@H](O)C(O)[C@H](O)CO HEBKCHPVOIAQTA-NGQZWQHPSA-N 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 235000019414 erythritol Nutrition 0.000 description 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 1
- 229940009714 erythritol Drugs 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000007366 host health Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000007413 intestinal health Effects 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 235000020183 skimmed milk Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/03—Organic compounds
- A23L29/045—Organic compounds containing nitrogen as heteroatom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/3463—Organic compounds; Microorganisms; Enzymes
- A23L3/3472—Compounds of undetermined constitution obtained from animals or plants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L3/00—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs
- A23L3/34—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals
- A23L3/3454—Preservation of foods or foodstuffs, in general, e.g. pasteurising, sterilising, specially adapted for foods or foodstuffs by treatment with chemicals in the form of liquids or solids
- A23L3/358—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/20—Agglomerating; Granulating; Tabletting
- A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Inorganic Chemistry (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention belongs to the technical field of microorganisms, and particularly relates to a probiotic tabletting preparation as well as a preparation method and application thereof. The probiotic tabletting preparation comprises the following components in parts by weight: 21-25 parts of live bacteria powder, 10-14 parts of adhesive, 30-35 parts of auxiliary material and 30-35 parts of corn starch. The probiotic tabletting preparation provided by the invention is white in appearance, smooth in surface, neat, intact, uniform in color and free of impurities; moderate hardness, small tablet weight difference, low disintegration time limit, and various performances superior to those specified in 'Chinese pharmacopoeia' 2015 edition. The adhesive of the invention not only increases the plastic deformation of the brittle particles and reduces the elasticity, thereby being beneficial to tabletting and preventing the problems of loosening and cracking; but also can promote the tabletting to be difficult to absorb moisture in the preservation process and prolong the shelf life. In addition, the probiotic tabletting preparation provided by the invention is easy to disintegrate and convenient to absorb by a human body.
Description
Technical Field
The invention belongs to the technical field of microorganisms, and particularly relates to a probiotic tabletting preparation as well as a preparation method and application thereof.
Background
Probiotics (Probiotics), derived from greek, means "beneficial to life", which usually inhabit the host gut, regulates the gut micro-ecology of the host (e.g. animal or human) and produces positive benefits of active microorganisms, often called friendly bacteria. From the scientific point of view, the probiotics refer to live bacteria preparation and metabolite thereof which can keep the intestinal health of the host by regulating the micro-ecology of the intestinal tract of the host to produce beneficial effect.
A microecological preparation (microecological preparation) is a preparation prepared by using normal microorganisms beneficial to a host or promoting substances thereof according to the microecological principle, and has the effects of maintaining or adjusting the microecological balance of the intestinal tract of the host, preventing and treating diseases and promoting the health of the host. With the deep research of micro ecology, the application of the micro ecology is more and more extensive.
Nowadays, probiotic tablets have the advantages of accurate dosage, stable quality, convenience in carrying and taking and the like, and are widely used. But the production operation of the tablet is high in technical performance, and a plurality of quality problems such as loosening, cracking, unqualified disintegration and the like easily occur in the production process.
Chinese patent CN 106359796A discloses a probiotic tabletting candy and a preparation method thereof, wherein the probiotic tabletting candy comprises the following components in parts by weight: 40-70 parts of starch, 10-30 parts of xylo-oligosaccharide, 20-40 parts of erythritol, 10-20 parts of glutamine, 5-15 parts of skimmed milk powder, 3-5 parts of probiotic powder and 0.5-1.5 parts of magnesium stearate. The probiotic tabletting candy has a large quantity of probiotics and strong activity, and has various physiological functions of promoting the function of an intestinal digestive system, maintaining the health of gastrointestinal mucosa, enhancing the immunity of a human body and the like. However, the preparation methods do not solve the problems that the probiotic tablet is easy to loose, split, and have unqualified disintegration degree in the production process.
Chinese patent CN 111657386 a provides a method for preparing probiotic pellet candy, comprising: (1) preparing mixed sugar powder; (2) mixing 3-8 parts of freeze-dried streptococcus salivarius K12 bacterial powder, 2-4 parts of porous starch and 0.5-1.5 parts of puffed corn flour; (3) mixing 30-50 parts of mixed sugar powder, 35-40 parts of adhesive, 10-20 parts of disintegrating agent, 0.2-1 part of lubricant, 2-4 parts of acidity regulator and 0.1-0.3 part of essence, granulating and sieving; (4) mixing the mixed auxiliary materials with a streptococcus salivarius K12 premix; (5) tabletting and forming, wherein the pressure is 70-80 KN; (6) drying in a drying oven at 30-40 ℃; (7) drying in a drying chamber until the water content is less than or equal to 0.2% to obtain the probiotic tabletting candy. The method solves the problems of easy occurrence of loose tablet and cracked tablet in the production process of probiotic tablet, but prolongs the disintegration time of the tablet.
Based on the problems, the invention provides a probiotic tabletting preparation and a preparation method thereof, and aims to solve the problems that the probiotic tablet is easy to loose, split, unqualified in disintegration degree and the like in the production process.
Disclosure of Invention
In order to solve the problems in the prior art, the invention aims to provide a probiotic compressed tablet preparation as well as a preparation method and application thereof. The probiotic tabletting preparation provided by the invention is white in appearance, smooth in surface, neat, intact, uniform in color and free of impurities; and after being stored for 2 months at 30 ℃, the viable count of the probiotic compressed tablet product is still as high as 4.1 multiplied by 106~4.4×106cfu/g; in addition, the probiotic compressed tablets obtained by the invention have moderate hardness, small tablet weight difference and low disintegration time limit, and all the performances are superior to those specified in 'Chinese pharmacopoeia' 2015 edition.
The technical scheme of the invention is as follows:
a probiotic tabletting preparation comprises the following components in parts by weight: 21-25 parts of live bacteria powder, 10-14 parts of adhesive, 30-35 parts of auxiliary material and 30-35 parts of corn starch.
Further, the paint comprises the following components in parts by weight: 23 parts of live bacteria powder, 13 parts of adhesive, 32 parts of auxiliary material and 32 parts of corn starch.
Further, the preparation method of the live bacterial powder comprises the following steps: and mixing the thallus collected after activation and propagation with a thallus protective agent, and performing spray drying to obtain viable bacteria powder. The thallus is probiotic thallus commonly used in the field, preferably lactobacillus acidophilus.
Further, the thallus protective agent comprises the following components: sodium caseinate, L-fucose and bone collagen peptide.
Further, the sodium caseinate: l-fucose: the weight ratio of the ossein protein peptide is 1: 4-6: 7-10; the preferred weight ratio is 1: 5: 8.
further, the amount of the cell protectant is 30% by weight of the cells.
Further, the adhesive is hydrotalcite and glutinous rice flour, and the weight ratio of the hydrotalcite to the glutinous rice flour is 1: 5.
further, the auxiliary materials comprise 8-13 parts of mannitol, 1-2.5 parts of magnesium stearate and 19.5-21 parts of glucose.
In addition, the invention also provides a preparation method of the probiotic tabletting preparation, which comprises the following preparation steps:
s1: preparing materials: putting mannitol and glucose into a mixer in proportion for uniform mixing to obtain a component A;
s2: preparing a soft material: dissolving corn starch with a formula amount in cold water at 15-30 ℃ in advance, and stirring to obtain a material-liquid ratio (0.3-0.7): 1, adding purified water with the temperature of 80-100 ℃, and uniformly stirring to form paste, thereby obtaining corn starch slurry; adding the corn starch slurry obtained in the step S2) into the component A obtained in the step S1, uniformly stirring to obtain a mixture wet material, and granulating to obtain wet granules; drying at 50-65 ℃ until the water content is 2.5-3.5% to obtain dry particles;
s3: tabletting: and (4) uniformly mixing the live bacteria powder, the magnesium stearate and the adhesive in the formula amount with the dry granules obtained in the step (S2), uniformly stirring, and tabletting to obtain the compound feed.
The corn starch in the step S2 is firstly mixed into a suspension with cold water and then further mixed into a paste, so that the agglomeration of the corn starch can be effectively prevented, and the phenomenon that the probiotic tablet is loosened due to the agglomeration is avoided.
Moreover, the invention also provides an application of the probiotic tabletting preparation in preparation of health products.
In the prior art, the problems of loosening, splitting, unqualified disintegration and the like easily occur in the production process of the probiotic tablet. The invention adopts sodium caseinate, L-fucose and ossein peptide as thallus protective agents, and utilizes the combined action of the sodium caseinate, the L-fucose and the ossein peptide to form a layer of protective film with a net structure, thereby not only enhancing the stability of viable bacteria, but also improving the moisture resistance of tabletting. In addition, sodium caseinate interacts with L-fucose and ossein peptide, the structure of corn starch can be improved, the cohesion of materials is improved, and the toughness of tabletting is effectively enhanced.
The water in the granules has great influence on the tablets, and the over-dried granules have large elasticity and small plasticity and are difficult to be pressed into the tablets; if the moisture content is too high, the tablets may be too soft and may even stick to the hopper or clog, thereby impairing the tableting effect. According to the invention, the hydrotalcite and the glutinous rice flour in a specific ratio are used as the adhesive, so that the moisture content in the tabletting is always kept in a better range, the plastic deformation of the brittle particles is increased, the elasticity is reduced, the tabletting is facilitated, and the problems of loosening and cracking are prevented; but also can promote the tabletting to be difficult to absorb moisture in the preservation process and prolong the shelf life.
Compared with the prior art, the probiotic tabletting preparation and the preparation method thereof provided by the invention have the following advantages:
(1) the probiotic tabletting preparation provided by the invention is white in appearance, smooth in surface, neat, intact, uniform in color and free of impurities; the detection shows that the viable count of the product of the probiotic tablet produced immediately after production is 5.1 multiplied by 106~5.3×106cfu/g, and the viable count of the product is still as high as 4.1 multiplied by 10 after the probiotic tablet is stored for 2 months at 30 DEG C6~4.4×106cfu/g, which shows that the preparation method of the probiotic tabletting preparation provided by the invention obviously improves the stability of probiotics and effectively prolongs the shelf life; the obtained probiotic compressed tablets have moderate hardness, small tablet weight difference and low disintegration time limit, and each performance is superior to the specification of 'Chinese pharmacopoeia' 2015 edition.
(2) The invention adopts sodium caseinate, L-fucose and ossein peptide as thallus protective agents, and utilizes the combined action of the sodium caseinate, the L-fucose and the ossein peptide to form a layer of protective film with a net structure, thereby not only enhancing the stability of viable bacteria, but also improving the moisture resistance of tabletting. In addition, sodium caseinate interacts with L-fucose and ossein peptide, the structure of corn starch can be improved, the cohesion of materials is improved, the toughness of tabletting is effectively enhanced, and the hardness of probiotic tabletting can reach the standard.
(3) The preparation method of the probiotic tabletting preparation provided by the invention is simple in process, green and environment-friendly, and easy for industrial production.
Detailed Description
The present invention is further illustrated by the following description of specific embodiments, which are not intended to limit the invention, and various modifications and improvements can be made by those skilled in the art based on the basic idea of the invention, but the invention is within the protection scope of the invention.
Wherein, the reagents used in the invention are all common reagents and can be purchased from common reagent production and sale companies.
EXAMPLE 1 preparation of probiotic tableting formulations
The formula is as follows: 21 parts of live bacteria powder, 10 parts of adhesive, 29.5 parts of auxiliary materials (8 parts of mannitol, 1 part of magnesium stearate, 19.5 parts of glucose) and 30 parts of corn starch.
The preparation method comprises the following steps: s1: preparing materials: putting 8 parts of mannitol and 19.5 parts of glucose into a mixer in proportion for uniform mixing to obtain a component A;
s2: preparing a soft material: dissolving 30 parts of corn starch in cold water at 30 ℃ in advance, and stirring to obtain a mixture with a feed-liquid ratio of 0.3: 1, adding purified water with the same mass and the temperature of 80 ℃, and uniformly stirring to form paste to obtain corn starch slurry; adding the corn starch slurry obtained in the step S2) into the component A obtained in the step S1, uniformly stirring to obtain a mixture wet material, and granulating to obtain wet granules; drying at 50 deg.C to water content of 2.5% to obtain dry granule;
s3: tabletting: and (4) uniformly mixing 21 parts of live bacteria powder, 1 part of magnesium stearate and 10 parts of adhesive with the dry granules obtained in the step (S2), uniformly stirring, and tabletting to obtain the compound feed.
The adhesive is hydrotalcite and glutinous rice flour, and the weight ratio of the hydrotalcite to the glutinous rice flour is 1: 5.
the preparation method of the viable bacteria powder comprises the following steps of mixing activated and expanded thallus (lactobacillus acidophilus) collected with a thallus protective agent, and performing spray drying to obtain viable bacteria powder. The using amount of the thallus protective agent is 30 percent of the thallus; the thallus protectant is sodium caseinate: l-fucose: collagen peptide, in a weight ratio of 1: 4: 7.
EXAMPLE 2 preparation of probiotic tableting formulations
The formula is as follows: 25 parts of live bacteria powder, 14 parts of adhesive, 36.5 parts of auxiliary materials (13 parts of mannitol, 2.5 parts of magnesium stearate and 21 parts of glucose) and 35 parts of corn starch.
The preparation method comprises the following steps: s1: preparing materials: putting 13 parts of mannitol and 21 parts of glucose into a mixer in proportion for uniform mixing to obtain a component A;
s2: preparing a soft material: taking 35 parts of corn starch, dissolving the corn starch in cold water at 30 ℃ in advance, and stirring to obtain a mixture with a feed-liquid ratio of 0.7: 1, adding purified water with the same mass and the temperature of 100 ℃ into the mixed suspension, and uniformly stirring the mixture into paste to obtain corn starch slurry; adding the corn starch slurry obtained in the step S2) into the component A obtained in the step S1, uniformly stirring to obtain a mixture wet material, and granulating to obtain wet granules; drying at 65 deg.C to water content of 3.5% to obtain dry granule;
s3: tabletting: and (4) uniformly mixing 25 parts of live bacteria powder, 2.5 parts of magnesium stearate and 14 parts of adhesive with the dry granules obtained in the step (S2), uniformly stirring, and tabletting to obtain the compound feed.
The adhesive is hydrotalcite and glutinous rice flour, and the weight ratio of the hydrotalcite to the glutinous rice flour is 1: 5.
the preparation of the viable bacteria powder was similar to example 1, except that the bacteria protectant was sodium caseinate: l-fucose: collagen peptide, in a weight ratio of 1: 6: 10.
EXAMPLE 3 preparation of probiotic tableting formulations
The formula is as follows: 23 parts of live bacteria powder, 13 parts of adhesive, 32 parts of auxiliary materials (10 parts of mannitol, 2 parts of magnesium stearate and 20 parts of glucose) and 32 parts of corn starch.
The preparation method comprises the following steps: s1: preparing materials: putting 10 parts of mannitol and 20 parts of glucose into a mixer in proportion for uniform mixing to obtain a component A;
s2: preparing a soft material: dissolving 32 parts of corn starch in cold water at 25 ℃ in advance, and stirring to obtain a mixture liquid ratio of 0.5: 1, adding purified water with the same mass and the temperature of 90 ℃, and uniformly stirring to form paste to obtain corn starch slurry; adding the corn starch slurry obtained in the step S2) into the component A obtained in the step S1, uniformly stirring to obtain a mixture wet material, and granulating to obtain wet granules; drying at 59 deg.C to water content of 3.0% to obtain dry granule;
s3: tabletting: and (4) uniformly mixing 23 parts of live bacteria powder, 2 parts of magnesium stearate and 13 parts of adhesive with the dry granules obtained in the step (S2), uniformly stirring, and tabletting to obtain the compound feed.
The adhesive is hydrotalcite and glutinous rice flour, and the weight ratio of the hydrotalcite to the glutinous rice flour is 1: 5.
the preparation of the viable bacteria powder was similar to example 1, except that the bacteria protectant was sodium caseinate: l-fucose: collagen peptide, in a weight ratio of 1: 5: 8.
comparative example 1 preparation method of probiotic tableting formulation
The comparative example 1 was prepared in a similar manner to example 3. The difference from example 3 is that propylene glycol alginate is used instead of sodium caseinate.
Comparative example 2 preparation method of probiotic tableting formulation
The comparative example 2 was prepared in a similar manner to example 3. The difference from example 3 is that the collagen peptide was replaced with soybean protein isolate.
Comparative example 3 preparation method of probiotic tableting formulation
The comparative example 3 was prepared in a similar manner to example 3. The difference from example 3 is that trehalose was used in place of L-fucose.
Comparative example 4 preparation method of probiotic tableting formulation
The comparative example 4 was prepared similarly to example 3. The difference from example 3 is that absolute ethyl alcohol is used instead of the binder.
Comparative example 5 preparation method of probiotic tableting formulation
The comparative example 5 was prepared in a similar manner to example 3. The difference from example 3 is that starch syrup is used instead of glutinous rice flour.
Test example I, Performance testing
And (3) observing the appearance of the product: the appearance of the tablet is determined according to the requirements of 'Chinese pharmacopoeia' of 2015 edition: the tablets are placed on white paper, and observed in natural light, the tablets are required to be smooth and tidy in surface, uniform in color, consistent in shape and good in smell.
And (3) detection of hardness: the hardness of the tablet is determined according to the requirements of 'Chinese pharmacopoeia' of 2015 edition: 20 probiotic tablets prepared according to examples 1-3 and comparative examples 1-5 were each tested, and the tablets were placed between 2 compression plates of a hardness tester and compressed in the diametrical direction, the pressure at which the tablets broke being the hardness, which should be > 30N.
Detection of piece weight difference: weighing 20 finished tablets by using a balance, wherein the weight of each tablet does not exceed the limit of weight difference or exceeds the limit of weight difference by less than or equal to 2 tablets according to the regulation of 'Chinese pharmacopoeia' 2015 edition, and any tablet cannot exceed the limit of weight difference by 1 time.
Detection of disintegration time limit: determining the disintegration time limit of the tablet according to the requirements of 'Chinese pharmacopoeia' of 2015 edition: respectively testing the probiotic tablets prepared in the examples 1-3 and the comparative examples 1-5, firstly putting 1000mL of distilled water into a disintegration apparatus, and enabling the water temperature to reach 37 ℃; then, 10 tablets were taken, placed in 18 baskets in a disintegrator, and the tablets were examined for complete disintegration within 900S.
Detecting the viable count of the product: respectively taking the finished product tablets just prepared for detection, then respectively taking the finished product tablets after being stored for 2 months at 30 ℃ for detection, weighing 50 tablets for each detection, dissolving and diluting to 100 mL by using sterile normal saline, then taking 1 mL as 10 times of incremental dilution, repeating the operation for several times, diluting to the required dilution degree according to the situation, respectively sucking 1 mL, injecting into an MRS solid culture medium, culturing for 48 h at 37 ℃, and calculating the number of viable bacteria.
The test results are shown in table 1.
Table 1 results of performance testing
As can be seen from Table 1:
the probiotic compressed tablets obtained in the group of example 1, the group of example 2 and the group of example 3 of the invention have the best effect, and the group of example 3 is the best example of the invention. The test results of the comparative example group and the example group show that the sodium caseinate, the L-fucose and the collagen peptide serving as the thallus protective agents provided by the invention have obvious synergistic effect due to lack of components, so that the stability of the viable bacteria can be enhanced, the preservation of the viable bacteria is facilitated, the structure of the corn starch can be improved, the cohesive force of the material is improved, the toughness of tabletting is effectively enhanced, the loose piece phenomenon is not generated, and the hardness of the probiotic tabletting can reach the standard; in addition, the adhesive of the invention not only increases the plastic deformation of the brittle particles and reduces the elasticity, is beneficial to tabletting and prevents the problems of loose tablets and splintering; but also can promote the tabletting to be difficult to absorb moisture in the preservation process and prolong the shelf life.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (10)
1. The probiotic tabletting preparation is characterized by comprising the following components in parts by weight: 21-25 parts of live bacteria powder, 10-14 parts of adhesive, 29.5-36.5 parts of auxiliary material and 30-35 parts of corn starch.
2. The probiotic tabletting formulation according to claim 1, comprising the following components in parts by weight: 23 parts of live bacteria powder, 13 parts of adhesive, 32 parts of auxiliary material and 32 parts of corn starch.
3. The probiotic tableting formulation according to claim 1 or 2, wherein the live bacterial powder is prepared by a method comprising: and mixing the thallus collected after activation and propagation with a thallus protective agent, and performing spray drying to obtain viable bacteria powder.
4. The probiotic tableting formulation according to claim 3, wherein the tropicalizing agent comprises the following components: sodium caseinate, L-fucose and bone collagen peptide.
5. The probiotic tableting formulation as claimed in claim 4, wherein the ratio of sodium caseinate: l-fucose: the weight ratio of the ossein protein peptide is 1: 4-6: 7 to 10.
6. The probiotic pellet formulation of claim 3, wherein the amount of the protectant is 30% by weight of the pellet.
7. The probiotic tableting formulation according to claim 1 or 2, wherein the binder is hydrotalcite and glutinous rice flour in a weight ratio of 1: 5.
8. the probiotic tabletting preparation according to claim 1 or 2, wherein the excipient comprises 8 to 13 parts of mannitol, 1 to 2.5 parts of magnesium stearate, and 19.5 to 21 parts of glucose.
9. A method for preparing the probiotic compressed tablet formulation according to any one of claims 1 to 8, characterized in that the preparation method comprises the following steps:
s1: preparing materials: putting mannitol and glucose into a mixer in proportion for uniform mixing to obtain a component A;
s2: preparing a soft material: dissolving corn starch with a formula amount in cold water at 15-30 ℃ in advance, and stirring to obtain a material-liquid ratio (0.3-0.7): 1, adding purified water with the temperature of 80-100 ℃, and uniformly stirring to form paste, thereby obtaining corn starch slurry; adding the corn starch slurry obtained in the step S2) into the component A obtained in the step S1, uniformly stirring to obtain a mixture wet material, and granulating to obtain wet granules; drying at 50-65 ℃ until the water content is 2.5-3.5% to obtain dry particles;
s3: tabletting: and (4) uniformly mixing the live bacteria powder, the magnesium stearate and the adhesive in the formula amount with the dry granules obtained in the step (S2), uniformly stirring, and tabletting to obtain the compound feed.
10. Use of a probiotic compressed tablet formulation according to any one of claims 1 to 8 in the preparation of a health product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210189324.9A CN114431477A (en) | 2022-03-01 | 2022-03-01 | Probiotic tabletting preparation and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210189324.9A CN114431477A (en) | 2022-03-01 | 2022-03-01 | Probiotic tabletting preparation and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114431477A true CN114431477A (en) | 2022-05-06 |
Family
ID=81374087
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210189324.9A Pending CN114431477A (en) | 2022-03-01 | 2022-03-01 | Probiotic tabletting preparation and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114431477A (en) |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2544881A1 (en) * | 1974-10-08 | 1976-04-22 | Hayashibara Biochem Lab | TABLET |
| CN103444969A (en) * | 2013-09-17 | 2013-12-18 | 南京通泽农业科技有限公司 | Process for preparing probiotics tabletting candies |
| CN104970101A (en) * | 2015-07-28 | 2015-10-14 | 天津中天精科科技有限公司 | Probiotics troche and preparation method thereof |
| CN107868769A (en) * | 2017-12-18 | 2018-04-03 | 江南大学 | A kind of high activity bifidobacteria freeze-dried vaccine powder producing method and application |
| CN113017081A (en) * | 2021-03-11 | 2021-06-25 | 重庆市生物技术研究所有限责任公司 | Ganoderma lucidum spore powder tablet and preparation method thereof |
-
2022
- 2022-03-01 CN CN202210189324.9A patent/CN114431477A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2544881A1 (en) * | 1974-10-08 | 1976-04-22 | Hayashibara Biochem Lab | TABLET |
| CN103444969A (en) * | 2013-09-17 | 2013-12-18 | 南京通泽农业科技有限公司 | Process for preparing probiotics tabletting candies |
| CN104970101A (en) * | 2015-07-28 | 2015-10-14 | 天津中天精科科技有限公司 | Probiotics troche and preparation method thereof |
| CN107868769A (en) * | 2017-12-18 | 2018-04-03 | 江南大学 | A kind of high activity bifidobacteria freeze-dried vaccine powder producing method and application |
| CN113017081A (en) * | 2021-03-11 | 2021-06-25 | 重庆市生物技术研究所有限责任公司 | Ganoderma lucidum spore powder tablet and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 肖怀秋等: "益生菌喷雾干燥影响机制及优化策略分析", 《食品与发酵工业》, no. 8, pages 248 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP7385930B2 (en) | Formulation for the treatment of inflammatory bowel diseases using whole plant fiber extract from sugarcane | |
| US10117884B2 (en) | Processing of natural polysaccharides by selected non-pathogenic microorganisms and methods of making and using the same | |
| JP5826107B2 (en) | Composition for enteral administration of microorganisms | |
| RO106953B1 (en) | Tablets with cholestiramine and preparation process thereof | |
| Park et al. | Enzymatic production of soluble dietary fiber from the cellulose fraction of Chinese cabbage waste and potential use as a functional food source | |
| CN101999713A (en) | Spirulina tablets and preparation method thereof | |
| CN108244245A (en) | Milk tablet and preparation method thereof | |
| JP2017039658A (en) | Drug for controlling intestinal function | |
| JP2008043206A (en) | Orally-ingested solid composition, and method for producing the same | |
| CN114431477A (en) | Probiotic tabletting preparation and preparation method and application thereof | |
| EP3556226A1 (en) | Complex synbiotic for establishing healthy intestinal flora | |
| CN114259057A (en) | Auxiliary material composition and probiotic powder thereof | |
| JP5073174B2 (en) | Method for producing tablets containing viable bacteria agent, digestive enzyme agent and both | |
| JP5100634B2 (en) | Orally rapidly disintegrating tablets | |
| KR102163637B1 (en) | Method for producing functional health food | |
| CN114916607B (en) | Tablet candy containing probiotics, preparation and packaging method thereof | |
| JP7464297B2 (en) | Intestinal regulator | |
| KR102167931B1 (en) | Method for producing functional health food | |
| JP2019116447A (en) | Solid preparation and production method thereof | |
| JP2006347981A (en) | Tablet containing tricholoma matsutake sing. mycelium | |
| Legowo et al. | Physical and microbiological characteristics grain kefir tablets in different tablet manufacturing methods. | |
| JP3942716B2 (en) | Aloe pills | |
| CN113854388A (en) | Probiotic tabletting candy containing undaria pinnatifida polysaccharide fermentation product and preparation method | |
| 권기철 | Characteristics of inulin-based synbiotic powders and granules encapsulating Lactobacillus rhamnosus GG | |
| JPH0549649B2 (en) |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220506 |