WO2017159767A1 - フコイダン育毛剤 - Google Patents
フコイダン育毛剤 Download PDFInfo
- Publication number
- WO2017159767A1 WO2017159767A1 PCT/JP2017/010571 JP2017010571W WO2017159767A1 WO 2017159767 A1 WO2017159767 A1 WO 2017159767A1 JP 2017010571 W JP2017010571 W JP 2017010571W WO 2017159767 A1 WO2017159767 A1 WO 2017159767A1
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- WIPO (PCT)
- Prior art keywords
- fucoidan
- hair
- microneedle
- hair growth
- growth
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/87—Application Devices; Containers; Packaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/88—Two- or multipart kits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/91—Injection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0061—Methods for using microneedles
Definitions
- the present invention relates to a hair restorer mainly composed of fucoidan.
- Fucoidan is a kind of acidic polysaccharide polymer containing fucose sulfate as the main constituent sugar. Fucoidan is a viscous component contained in brown algae such as seaweed, mozuku and kelp, but is known to have a hair-growth effect.
- a hair restoration composition containing fucoidan (Patent Document 1), a cosmetic containing fucoidan or a decomposition product thereof having a hair restoration effect (Patent Document 2), and a food and drink having fucoidan having a hair growth effect.
- fucoidan is a polymer with an average molecular weight of 1 million or more is more effective for hair growth (Patent Document 4), oral hair restorer combining fucoidan and seaweed-derived protein (Patent Document 5), fucoidan and soybean A hair-restoring agent containing a protein (Patent Document 6) and a hair repairing agent containing Fucoidan containing propolis and the like (Patent Document 7) have already been published. These are all oral preparations or coating agents.
- a microneedle array is a large number of microneedles integrated on a substrate.
- a product that is easy to use by adding an adhesive tape for attaching the microneedle array to the skin or a cover sheet for maintaining sterility until use is called a microneedle patch.
- the tape means a film or cloth or paper coated with an adhesive.
- Microneedles can be made using a water-insoluble material such as stainless steel or polylactic acid.
- a microneedle made using a substance that dissolves in water in the body such as sugar (biosoluble polymer substance)
- the base means a main component constituting the microneedle.
- a microneedle array made of a biosoluble polymer material is often manufactured using a template.
- a microneedle pattern is formed by a lithography method using a photosensitive resin and then transferred to create a mold having a microneedle-forming recess.
- a microneedle array can be obtained by casting a microneedle material onto this mold and then heating to evaporate the moisture, and then separating the solidified material from the mold.
- JP 2003-155218 A Special Reprint WO01 / 039731 JP 2005-281277 A JP 2007-262036 A JP 2008-169140 A JP 2009-114170 A JP 2014-218440 A
- the inventors of the present invention have used fucoidan which has an excellent hair-growth effect, and continue to study with the expectation that administration with a microneedle will exhibit a much better hair-growth effect compared to conventional liquid administration.
- the invention has been reached.
- the hair-restoring agent according to the present invention made to solve the above-mentioned problems is a combination of a microneedle containing fucoidan and a coating agent containing fucoidan.
- the administration of fucoidan is effective even when the fucoidan-containing microneedle is administered alone, but the effect is further enhanced by the combined use of the fucoidan-containing microneedle and the fucoidan-containing liquid agent (essence). Even with only the fucoidan-containing microneedles, the hair-growth effect far superior to that of applying an essence containing fucoidan to the skin is exhibited. Furthermore, the combination of the two (combination produces a further excellent effect and is a feature of the present invention. Although the mechanism is not irritating, fucoidan containing microneedles percutaneously penetrates through the skin pores formed by microneedles.
- the hair-growth method of the present invention is characterized in that the hair-growth effect is enhanced by the administration of the fucoidan-containing microneedle and further the administration of the fucoidan-containing microneedle and the fucodyne-containing liquid.
- the timing of the combined use may be the simultaneous administration of the microneedle and the liquid or the administration with a time shift.
- the length of the fucoidan-containing microneedle is suitably 0.1 to 1.5 mm. A more suitable length is 0.15 mm to 1.0 mm. When the length is 0.1 mm or less, the function as a microneedle cannot be sufficiently exhibited. If the length is 1.0 mm or more, the effect is sufficient, but it causes pain during administration and causes a problem in compliance with the user.
- a water-soluble polymer is desirable.
- biosoluble polymers such as hyaluronic acid, collagen, hydroxypropylcellulose, chondroitin sulfate, etc. diffuse moisture in the skin into the needle within a short time after insertion, and the needle inserted into the skin swells. Since it melt
- ⁇ As fucoidan-containing coating agents not only liquid agents but also creams, mousses, gels, etc. can be used in combination with the microneedle method.
- the amount of fucoidan in the hair-growth agent varies depending on the administration form, administration method, desired effect, treatment period, etc., and cannot be specified unconditionally. Typically, however, a concentration of 0.1 ⁇ g / mL to 100 mg / mL is appropriate for solutions or creams.
- one to several microneedle arrays are contained in one application amount, and 0.1 ⁇ g to 2 mg per microneedle array is appropriate.
- hair growth promoters can be added to the hair restorer for the purpose of complementing or enhancing the hair growth activity.
- minoxidil, carpronium chloride, t-flavanone, adenosine, 6-benzylaminopurine, pentadecanoic acid glyceride, herbal extract and the like are suitable.
- the hair-growth agent if necessary, within the range that does not impair the purpose and effect of the hair-growth agent, plant extracts that are recognized as drugs, cosmetics, quasi drugs, pharmaceuticals, etc.
- Examples of the plant extract include capsicum, aloe, tea, shinny, wasabi, joteishi, Dutch sennici, gardenia, usbassaicin, garlic, mint, yakuinin, giraffe palm, burdock, licorice, amachazul, scallop, diau, glycyrrhizic acid
- Examples include monoammonium, glycyrrhetinic acid, glycyrrhizin, sesame, senkyu, kashi, yotei, carrot, ginger tincture, and the like, and these can be used singly or in combination.
- the fucoidan-containing microneedle of the present invention can be more effective than a single coating agent used alone. Furthermore, by using both the administration of the fucoidan-containing microneedle and the administration of the fucoidan-containing coating agent, the hair-growth effect can be further enhanced than when either one is used alone.
- the hair restorer of the present invention is a preparation that can be used as any preparation that can be widely used as a pharmaceutical, a quasi-drug, a cosmetic, and the like.
- FIG. 1 is a diagram of a method for producing a fucoidan-containing microneedle array.
- FIG. 2 is a diagram comparing the effects of various methods of administering the hair restorer of the present application and of the effects of other hair restorers. In the figure, the vertical axis represents the amount of hair growth (mg / cm 2 ).
- FIG. 3A is a head photograph showing the hair-growth effect of the paneler in hair-growth test 3.
- FIG. 3B is a head photograph showing the hair-growth effect of another panelist in hair-growth test 3.
- FIG. FIG. 4 is a graph showing the results of a questionnaire on the use of hair growth agents for the panelists after the completion of the hair growth test 3.
- FIG. 5 is a graph showing evaluation of hair growth and hair loss for the panel after the completion of the hair growth test 3.
- FIG. 6 is a graph showing the effect realized by the paneler after the hair growth test 3 was completed.
- the present invention is not limited to the contents of the examples.
- the fucoidan of the present invention one purified from Mozuku was used. Commercially available products (rim bale, Tanglewood Co., Ltd.) can be used for this.
- a microneedle pattern having a predetermined shape was formed as shown in FIG. 1 by a lithography method in which the photosensitive resin was irradiated with light.
- the microneedle pattern was electroformed to form a mold 10 having a microneedle forming recess 11 to which the pattern was transferred.
- the concave portions 11 for forming the microneedle are of a cone type with a root diameter of 200 ⁇ m and a depth of 300 ⁇ m, and are arranged in a grid pattern at intervals of 600 ⁇ m, and are formed at 280 per cm 2 .
- the microneedle array 12 was molded using the concave mold for forming.
- Hyaluronic acid (FCH-80, culture-derived, Kikkoman Biochemifa Co., Ltd.) 5 g and Rimvale HV (fucoidan 1.2% aqueous solution, Tanglewood Co., Ltd.) 5 g were added to 90 g of water to obtain a uniform solution.
- the aqueous solution was cast on the mold 10, dried at room temperature for 24 hours, and extracted from the mold to obtain a microneedle array sheet. The sheet was cut to obtain a microneedle array having a diameter of 1 cm.
- the fucoidan content per microneedle array was 25 ⁇ g.
- Rim bale HV 0.1g was dissolved in water 200g, and it was set as the fucoidan containing extract.
- Fucoidan-containing microneedles (fMN) and fucoidan-containing extract (fEX) were administered at predetermined intervals for 22 days, and the amount of hair growth was measured after 24 days.
- one patch was administered per administration, and in the case of a contained extract, 50 ⁇ L of the extract was administered to about 1 cm 2 .
- the amount of fucoidan was the same at 25 ⁇ g.
- Table 1 From Table 1, it can be seen that the combined use of the fucoidan-containing microneedle and the fucoidan-containing extract has an excellent hair growth effect.
- the administration interval is every other day, which means that fMN was administered on the first day and fEX was administered on the next day for a total of 11 times for fMN and fEX for 22 days respectively.
- the administration interval is 2 out of 3 days: fMN is administered on the first day, fEX is administered on the next day, and the administration is suspended on the next day for a total of 8 times for 23 days.
- fMN is administered on the first day
- fEX is administered on the next day
- the administration is suspended on the next day for a total of 8 times for 23 days.
- hair growth effects were compared in various administration methods. As in the hair growth test 1, C3H / HeN mice were shaved and shaved. Table 2 summarizes the drugs and methods of administration. In order to quantify the hair growth state, hair that had grown after 40 days was shaved off, washed and dried, and the weight was measured.
- the administered drug is slightly different from the hair growth test 1.
- the carrot extract (1 g of Maruzen Pharmaceutical Co., Ltd. and 1 g of ginger tincture (Maruzen Pharmaceutical Co., Ltd.) was added to 5 g of the rim veil HV instead of 5 g of the rim veil HV alone of the hair growth test 1.
- the production method is the same as in the hair growth test 1.
- rim veil liquid (LQ) was used, and its fucoidan content was not 0.1 g rim bale HV in hair growth test 1, but 0.1 g rim bale HV and 0.02 g carrot extract (Maruzen Pharmaceutical Co., Ltd.) and Maruzen Pharmaceutical Co., Ltd.) was added in an amount of 0.02 g, and the manufacturing method of the coating agent was exactly the same.
- the drug dose was 25 ⁇ g in both MN and LQ in terms of fucodyne.
- the reference example (commercial product) used a minoxidil 5% aqueous solution (Reup) (X), and the dosage was 40 ⁇ L.
- Table 2 shows the administration cycle of each preparation in the hair growth test, and FIG. 2 shows the results of the hair growth 40 days after the completion of the administration.
- the unit of hair growth is mg / cm 2 .
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Abstract
Description
このように経口法や塗布法は、薬物の利用が非効率であるとの問題点がある。
このマイクロニードルを基板上に多数集積したものがマイクロニードルアレイである。また、マイクロニードルアレイに、マイクロニードルアレイを皮膚に付着させるための粘着テープや使用まで無菌状態を維持するためのカバーシートなどを付加して使用しやすい製品としたものをマイクロニードルパッチという。ここにテープとは、フィルム、もしくは布又は紙に粘着剤を塗布したものをいう。
このようなマイクロニードルを利用して薬物を経皮的に投与する多くの試みがすでになされているが、育毛剤としての利用は未だ報告されていないようである。
生体溶解性高分子物質からなるマイクロニードルアレイは、鋳型を用いて製造されることが多い。感光性樹脂を用いてリソグラフィ法によりマイクロニードルパターンを形成した後転写し、マイクロニードル形成用凹部を有する鋳型を作成する。マイクロニードル素材をこの鋳型上に流延し、次に加熱して水分を蒸発させた後、固化したものを鋳型から剥離してマイクロニードルアレイを得ることができる。
すなわち本発明の育毛方法は、フコイダン含有マイクロニードルの投与と、さらにはフコイダン含有マイクロニードルとフコダイン含有液剤の投与との併用により、育毛効果を高めたことを特徴とする。併用の時期としてはマイクロニードルと液剤とを同時投与しても時間をずらせての投与であってもよい。
さらにフコイダン含有マイクロニードルの投与と、フコイダン含有塗布剤の投与とを併用することにより、いずれかを単独で用いるより、より育毛効果を高めることができる。
本発明の育毛剤は、医薬品、医薬部外品、化粧品などとして幅広く利用可能な任意の製剤として利用可能な製剤である。
本発明のフコイダンとしては、モズクから精製されたものを用いた。これには市販品(リムベール、タングルウッド(株))を用いることができる。
感光性樹脂に光照射するリソグラフィ法により所定形状のマイクロニードルパターンを図1に示すように形成した。このマイクロニードルパターンを電鋳加工して、そのパターンを転写したマイクロニードル形成用凹部11を有する鋳型10を形成した。マイクロニードル形成用凹部11は、根本の直径が200μmで深さ300μmのコニーデ型であり、600μm間隔に格子状に配置され、1cm2当たり280個形成されている。本形成用凹部鋳型を用いてマイクロニードルアレイ12を成形した。
雄性C3H/HeNマウス(日本チャールズ・リバー(株))を予備飼育し、6週齢のときその背部をバリカンにより毛刈りし、更にカミソリにより毛剃りし、実験に用いた。
フコイダン含有マイクロニードル(fMN)及びフコイダン含有エキス(fEX)を所定の間隔で22日間投与し、24日後に発毛量を測定した。
投与1回当たりの投与量は、マイクロニードルの場合 1枚のパッチを投与し、含有エキスの場合エキス50μLを約1cm2に投与した。いずれの場合もフコイダン量は25μgで同量であった。結果を表1にまとめる。表1より、フコイダン含有マイクロニードルとフコイダン含有エキスの併用が、育毛効果に優れていることが解る。
フコイダン含有エキスを主有効成分として種々の投与法において育毛効果を比較した。育毛試験1と同様にC3H/HeNマウスを剃毛し毛剃りした。
投与薬物と投与方法とを表2にまとめた。育毛状態を定量化するために40日後に生えて来た毛をそり落とし、洗浄し乾燥して重量を測定した。
塗布剤としてはリムベール液剤(LQ)を用い、そのフコイダン含有量は育毛試験1のリムベールHV0.1gではなく、リムベールHV0.1gにニンジンエキス(丸善製薬(株))0.02gとショウキョウチンキ(丸善製薬(株))0.02gとを加えたもので、塗布剤の製造方法は全く同じであった。
薬物投与量は、フコダイン換算でMNにおいてもLQにおいても25μgであった。参考例(市販品)はミノキシジル5%水溶液(リアップ)(X)を用い、その投与量は40μLであった。
育毛試験の各製剤の投与サイクルを表2に、投与終了後40日後の発毛量の結果を図2に示す。発毛量の単位はmg/cm2である。
化粧品、医薬部外品の効能を評価する専門機関においてボランティアに実施した。ボランティアの被験者に対しては、インフォームドコンセントを得て各種テストを実施した。実施の概要は以下のようであった。
1.パネラー 男4名(48-57歳)、女8名(47-59歳)
2.試験期間 12週間
3.使用方法
育毛ニードル及び育毛塗布剤は実施例2に用いたものと同様。
育毛ニードル適用回数 3回/週
育毛塗布剤適用回数 朝・夜使用
4.効果の評価
使用前と12週間後の頭部写真で判定した。12名中からの代表例を2つ示す。2名のパネラーの頭部は、育毛ニードルを貼付した部位を中心にして、12週間後に頭髪の増加が肉眼で顕著に観察された(図3A、図3B)。
12名のパネラーに対する評価結果及びアンケート結果を示す(図4~6)。本発明の育毛剤の使用に関して、2/3が満足しており、80%以上のパネラーが継続して使用したい意向を示した(図4)。抜け毛の減少、毛髪の増量については、過半数のパネラーが効果を実感しており(図5)、効果を実感したパネラーや今後の効果を期待するパネラーが継続の意思を表明したと考察される。また、抜け毛減少や発毛以外に、髪が太くなる、髪のボリュームがアップする、髪のハリとコシがアップする、白髪が減少するという効果も実感しており、87%のパネラーが頭髪に対して何らかの有利な効果を実感していることがわかった(図6)。13%のパネラーは効果がないと回答したが、頭髪への悪影響は観察されなかった。
Claims (6)
- フコイダン含有マイクロニードルと、フコイダン含有塗布剤との組合せから構成される育毛剤。
- 前記フコイダン含有マイクロニードルの基剤が生体溶解性高分子であることを特徴とする請求項1に記載の育毛剤。
- 前記フコイダン含有マイクロニードルと前記フコイダン含有塗布剤中のフコイダンが褐藻由来のものであることを特徴とする請求項1に記載の育毛剤。
- 薬剤としてさらににんじんエキスとショウキョウチンキを含有する請求項1~3のいずれか1項に記載の育毛剤。
- 前記フコイダン含有マイクロニードルと、前記フコイダン含有塗布剤とを併用することを特徴とする育毛方法(医療行為を除く)。
- フコイダン含有マイクロニードル単独で構成される育毛剤。
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AU2017232597A AU2017232597B2 (en) | 2016-03-16 | 2017-03-16 | Fucoidan hair growth agent |
KR1020187026474A KR102547129B1 (ko) | 2016-03-16 | 2017-03-16 | 푸코이단 육모제 |
EP17766763.1A EP3431073B1 (en) | 2016-03-16 | 2017-03-16 | Fucoidan hair growth agent |
CN201780016596.6A CN108778238B (zh) | 2016-03-16 | 2017-03-16 | 褐藻糖胶育发剂 |
US17/498,197 US11890298B2 (en) | 2016-03-16 | 2021-10-11 | Fucoidan hair growth agent |
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US17/498,197 Division US11890298B2 (en) | 2016-03-16 | 2021-10-11 | Fucoidan hair growth agent |
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EP3815737A4 (en) * | 2018-06-26 | 2022-03-30 | Hisamitsu Pharmaceutical Co., Inc. | MICRO-NEEDLE DEVICE AND METHOD OF MAKING IT |
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JP2021504391A (ja) * | 2017-11-30 | 2021-02-15 | マイクロキュアーズ, インコーポレイテッド | 毛包および発毛を修復する方法 |
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- 2017-03-16 CN CN201780016596.6A patent/CN108778238B/zh active Active
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EP3431073B1 (en) | 2023-11-08 |
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CN108778238A (zh) | 2018-11-09 |
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CA3017448A1 (en) | 2017-09-21 |
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AU2017232597A1 (en) | 2018-10-04 |
US20220023184A1 (en) | 2022-01-27 |
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