WO2017110815A1 - マイクロニードルパッチアプリケータ及びそのハウジング - Google Patents
マイクロニードルパッチアプリケータ及びそのハウジング Download PDFInfo
- Publication number
- WO2017110815A1 WO2017110815A1 PCT/JP2016/087965 JP2016087965W WO2017110815A1 WO 2017110815 A1 WO2017110815 A1 WO 2017110815A1 JP 2016087965 W JP2016087965 W JP 2016087965W WO 2017110815 A1 WO2017110815 A1 WO 2017110815A1
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- WIPO (PCT)
- Prior art keywords
- housing
- axis
- microneedle patch
- patch applicator
- skin
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0023—Drug applicators using microneedles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
- A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
- A61M2037/0053—Methods for producing microneedles
Definitions
- the present invention relates to a microneedle patch applicator for attaching a microneedle patch to the skin of an animal (including humans and animals other than humans).
- the present invention also relates to a housing for a microneedle patch applicator.
- a drug administration system using a drug-coated microneedle patch has attracted attention as one of transdermal drug administration systems (see Patent Documents 1 to 7).
- this microneedle patch thin protrusions or needles with a length of several hundred microns are formed on a base material at a high density, and a needle carrying a target drug (molecules such as vaccine, protein, peptide) on the surface or inside is provided. It pierces the skin and transports the drug directly to the dermis or epidermis. It does not impose a burden on the liver like an internal medicine, and there is no pain associated with the penetration of a needle like an injection, and it is a temporary excessive drug. It has many advantages such as reducing side effects due to absorption.
- the needle of the microneedle patch is very thin (the diameter of the root is about several tens of microns). Therefore, it may be damaged or broken by resistance when entering the skin.
- a needle made of metal for example, titanium
- the risk of indwelling in the body due to broken skin is a major issue.
- needles made of biodegradable resin there is a higher possibility of breakage or breakage than metal needles.
- the needle is inclined with respect to the skin, the insertion property of the needle into the skin is reduced, or bending force acts on the needle and the needle is easily broken. Therefore, there is a need for means that can puncture the needle perpendicularly to the skin and that can reliably apply the microneedle patch to the skin.
- the present invention provides a microneedle patch applicator and a housing for a microneedle patch applicator that can enhance the vertical penetration of the needle into the skin and that can be reliably applied to the skin.
- An embodiment of a housing for a microneedle patch applicator comprises: A sheet or film having an upper surface and a lower surface, and a flat peripheral base, and a bulge that is surrounded by the peripheral base and bulges vertically upward from the lower surface toward the upper surface with respect to the peripheral base A housing having a portion, The lower surface portion of the raised portion constitutes a surface that supports the microneedle patch, The protuberance has a plurality of valley folds; The valley fold has a valley bottom facing away from the center of the raised portion.
- the valley fold is formed by two horizontal axes (x-axis, y-axis) perpendicular to the vertical axis (z-axis) passing through the center of the raised portion and perpendicular to each other. ).
- the valley folds are arranged in rotational symmetry (n-fold symmetry: n is an integer of 2 or more) with respect to the vertical axis (z-axis).
- the raised portion has a symmetrical shape with respect to at least one of the two horizontal axes (x axis, y axis).
- the raised portion has a symmetrical shape with respect to the two horizontal axes (x-axis and y-axis).
- the raised portion has one of the two horizontal axes (x axis, y axis) as a long axis (x axis) and the two horizontal axes.
- the other horizontal axis is a shape having a short axis (y-axis).
- the ridge is rotationally symmetric (n-fold symmetry: n is an integer of 2 or more) with respect to a vertical axis (z-axis) passing through the center of the ridge. is there.
- the raised portion has a recess in the center, and the lower surface portion of the recess constitutes a surface that supports the microneedle patch.
- the microneedle patch applicator in another embodiment, includes a ridge that extends along the contour of the ridge and surrounds the recess, and the ridge includes the plurality of valley folds.
- the contour has a symmetrical shape with respect to the two horizontal axes (x axis, y axis).
- the contour has one of the two horizontal axes (x axis, y axis) as a long axis (x axis) and the two horizontal axes.
- the other horizontal axis is the short axis (y-axis).
- the contour is rotationally symmetric (n-fold symmetry: n is an integer of 2 or more) with respect to the vertical axis (z-axis).
- the indentation is constituted by a flat surface, the flat surface being arranged symmetrically with respect to the short axis and parallel to the short axis (y-axis). It has two easily deformable portions that extend, and the flat surface is partitioned into a central region sandwiched between the two readily deformable portions and end regions located on both sides of the central region.
- the raised portions are continuously arranged in a circumferential direction around the vertical axis (z axis).
- the raised portions are discontinuously arranged in the circumferential direction around the vertical axis.
- At least a part of the plurality of valley folds has a valley bottom that is inclined downward in a direction away from the center of the raised portion.
- An embodiment of a microneedle patch applicator according to the present invention comprises: A housing for any of the microneedle patch applicators described above; A microneedle patch supported on a surface supporting the microneedle patch.
- the depression is provided with a finger holder.
- Embodiments of the microneedle patch applicator include A protective sheet is attached to the lower surface of the peripheral base of the housing; The protective sheet closes the opening of the microneedle patch accommodating space formed behind the raised portion.
- the finger holder is provided with an indicator that indicates that a predetermined force is applied to the finger holder.
- the microneedle patch applicator and its housing according to the present invention, when the raised portion is pressed, the patch supported on the back surface thereof is deformed perpendicularly and deeply to the skin. As a result, the entire patch is pressed against the skin vertically with uniform force. As a result, the needle installed in the patch penetrates vertically into the skin, so that the needle is not bent, broken or broken during puncture.
- FIG. 10 It is a perspective view of the deformation
- FIG. 17 (A) which looked at the microneedle patch applicator and its housing which concern on Embodiment 6 from diagonally upward and diagonally downward
- FIG. 17 (B) the perspective view which looked from diagonally downward.
- 10 is a perspective view of a microneedle patch applicator according to Embodiment 9.
- FIG. 9 is a perspective view of a microneedle patch applicator according to Embodiment 9.
- FIG. 23 (A) a disassembled perspective view of the microneedle patch applicator which concerns on Embodiment 9 shown in FIG. 21, and the front view (FIG. 23 (B)) of the torsion spring incorporated therein.
- FIG. 12 is a perspective view of a microneedle patch applicator according to an eleventh embodiment. It is a disassembled perspective view of the microneedle patch applicator which concerns on Embodiment 11 shown in FIG. It is a perspective view of the microneedle patch applicator of another form. It is the perspective view which decomposed
- FIG. 1 shows a microneedle patch applicator (hereinafter referred to as “applicator”) 1 according to a first embodiment.
- the applicator 1 has a container or housing 11 that houses a microneedle patch 40 (see FIG. 6) described later.
- the housing 11 is formed by, for example, molding a thin resin sheet or film (for example, vacuum molding, pressure molding, press molding) or by injecting molten resin into a cavity in a mold (for example, injection molding). And has the appearance shown in the figure.
- the material suitable for molding the housing is preferably a flexible material that can be easily bent, deformed and restored.
- These resins may be provided with a hygroscopic and / or oxygen absorbing function by including a hygroscopic agent and / or an oxygen absorbent as long as the above-described properties such as flexibility are not impaired.
- each part of the housing is appropriately determined so that a desired deformation described later occurs when a person pushes the housing 11 from above with a finger. That is, it is desirable that the housing has a feature that it can be easily bent at a valley fold described later.
- the thickness of each part is preferably about 50 ⁇ m to 1 mm, more preferably 100 ⁇ m to 500 ⁇ m.
- the housing 11 has a flat plate-like peripheral base 12 and a raised portion 13 that is surrounded by the peripheral base 12 and protrudes upward (in the z-axis direction in FIG. 1).
- the peripheral base 12 is surrounded by a substantially rectangular outer edge 14.
- the raised portion 13 has a substantially rectangular outline 15 that is substantially similar to the rectangular outer edge 14 of the peripheral base 12.
- the contour 15 has a pair of long side direction contours 16 extending in the long side direction (x-axis direction in FIG. 1) of the rectangular peripheral base 12 and a pair of short sides extending in the short side direction (y-axis direction in FIG. 1).
- a side outline 17 is provided.
- the raised portion 13 has a substantially square frustum shape, and has a long side direction side wall 18 and a short side direction side wall 19 extending upward from the long side direction contour portion 16 and the short side direction contour portion 17 respectively.
- the long side wall 18 and the short side wall 19 may be inclined inward.
- the upper surface of the ridge 13 includes a long-side inclined upper surface 22 and a short-side inclined upper surface 23 extending from the upper end 20 of the long side wall 18 and the upper end 21 of the short side wall 19 toward the center of the ridge 13.
- the long side direction inclined upper surface portion 22 and the short side direction inclined upper surface portion 23 are preferably inclined downward from the upper end 20 and the upper end 21 inward.
- the long side direction inclined upper surface part 22 and the short side direction inclined upper surface part 23 are respectively predetermined with respect to the upper end 20 of the long side direction side wall 18 and the upper end 21 of the short side direction side wall 19 when the raised portion 13 is viewed from above. They are in contact at a boundary extending in a direction that forms an angle (for example, approximately 45 degrees). As described above, since the long side direction inclined upper surface portion 22 and the short side direction inclined upper surface portion 23 are inclined obliquely downward toward the center of the raised portion 13, the boundary forms a valley fold portion 24.
- the valley fold portion 24 may be made thinner than the left and right regions (upper surface portions 22, 23), or the cross section of the portion may be formed in a U shape or an inverted U shape.
- a recess 25 is formed at the center of the raised portion 13.
- the recess 25 has a peripheral wall portion 26 extending downward from the inner edges of the long side direction inclined upper surface portion 22 and the short side direction inclined upper surface portion 23, and a substantially flat bottom portion 27 connected to the lower end of the peripheral wall portion 26. .
- the depression 25 has a track shape when viewed from above.
- the bottom portion 27 of the recess 25 has two easily deformable portions 28 extending in the short side direction.
- the easily deformable portion 28 is arranged symmetrically at the center of the recess 25 (intersection of the X axis, the Y axis, and the Z axis shown in the figure), and in the central region 29 sandwiched between the two easily deformable portions 28.
- the end regions 30 located on both sides thereof are easily bent upward.
- the easily deformable portion 28 may be a thin portion whose portion is thinner than other portions, or may be a deformed portion whose section is bent in a U shape or an inverted U shape.
- the depression 25 of the raised portion 13 may be provided with a finger holding portion (pressing portion) 31 for the user to press the finger during operation.
- the finger holder 31 has a contour that is substantially the same as or slightly smaller than the contour of the recess 25.
- the finger holder 31 is composed of an upper member 32 and a lower member 33.
- the upper member 32 has a track shape that is approximately the same size as the recess 25 when viewed from above.
- the lower member 33 has support portions 34 protruding upward from the upper surface of the lower member 33 at both ends in the long side direction (near the arc portion).
- a boss (projection) 35 protruding upward from its upper surface is provided.
- the boss 35 has a cylindrical shape.
- the lower surface of the lower member 33 is an inclined surface in which the end region 36 extends obliquely upward from the edge of the central region 37 toward the outside.
- the upper member 32 has a pair of protruding portions 38 corresponding to the support portions 34 of the lower member 33 and protruding downward from the lower surface of the upper member 32.
- the protrusion 38 is positioned on the outer edge of the support 34 so that the upper member 32 is positioned with respect to the lower member 33.
- the upper member 32 is also formed with a through hole 39 extending in the vertical direction at the center.
- the cross section of the through hole 39 is preferably larger or slightly larger than the cross section of the boss 35 of the lower member 33.
- the position of the through hole 39 is determined so that when the upper member 32 is assembled on the lower member 33, the boss 35 and the through hole 39 are coaxially located and face each other in the vertical direction.
- the upper member 32 and the lower member 33 are determined by placing a finger on the upper surface of the upper member 32 and applying a predetermined amount thereto.
- a pressing force (described later) is applied, the central portion of the upper member 32 bends downward with respect to both side portions thereof, or the central portion of the lower member 33 bends relatively upward with respect to both side portions thereof.
- the central portions of the upper member 32 and the lower member 33 bend downward and upward, respectively.
- the boss 35 penetrates the through hole 39 of the upper member 32 and protrudes a predetermined length on the upper surface thereof so as to hit the finger. It is decided. Therefore, it is preferable to select an elastic material capable of such deformation for the upper member 32 and the lower member 33.
- the finger holder 31 configured in this manner is arranged in the recess 25 by combining the upper member 32 and the lower member 33.
- the combined upper member 32 and lower member 33 may be integrated by bonding with an adhesive, or may be integrally formed.
- the central region 37 on the lower surface of the lower member and the central region 29 at the bottom of the recess facing the lower region may be bonded with an adhesive or a double-sided tape.
- the finger holder 31 does not need to be attached to the housing 11 in advance, and the finger holder 31 may be placed in the recess 25 before the applicator 1 is used.
- the microneedle patch (hereinafter referred to as “patch”) 40 is accommodated in a patch accommodating space 41 formed on the back surface of the raised portion 13, and is formed by the back surface of the recess 25. 42 is fixed.
- the patch 40 generally has a sheet base material 43 and a microneedle array 44 supported by the sheet base material 43.
- the sheet base material 43 opposes the base material film 45, the adhesive layer 46 provided on the lower surface of the base material film 45 (support surface of the microneedle array 44), and the upper surface of the base material film 45 (patch support surface 42).
- a release treatment layer (release layer) 47 provided on the surface).
- the microneedle array 44 has a rectangular (or circular) base layer 48 and a predetermined height arranged in a lattice or honeycomb form with a predetermined interval (for example, 300 to 1000 micrometers) on the lower surface of the base layer 48.
- the microneedle array 44 is made by filling a biodegradable synthetic polymer material (for example, hyaluronic acid, collagen, polylactic acid, polyglycolic acid) into a mold having a corresponding shape.
- a target drug molecules such as vaccine, protein, peptide, etc.
- the microneedle array 44 is composed of a biodegradable resin, the target drug can be included in the needle 49 during molding.
- the sheet base material 43 and the microneedle array 44 are integrated by attaching the base layer 48 of the microneedle array 44 on the adhesive layer 46 of the sheet base material 43. As shown in FIGS. 5 and 6, the sheet base material 43 is larger than the microneedle array 44. Therefore, the adhesive layer 46 having a sufficient area is exposed around the microneedle array 44 with the microneedle array 44 attached to the sheet base material 43.
- the patch 40 formed in this manner is attached to the patch support surface 42 using a double-sided tape 50.
- the microneedle array 44 is positioned in the patch support surface center region 37 corresponding to the recess center region 29, and the double-sided tapes 50 on both sides are placed in the patch support surface end region 36 corresponding to the recess end region 30. To position.
- the double-sided tape 50 temporarily holds the patch 40 on the patch support surface 42 before applying the patch 40 to the skin. Further, after the patch 40 is attached to the skin, the patch 40 needs to be separated from the housing 11 and held on the skin. Therefore, the conditions (size, shape, mounting position, adhesive strength) of the double-sided tape 50 are such that the adhesive strength between the double-sided tape 50 and the release treatment layer (release layer) 47 is the adhesive strength between the adhesive layer 46 and the skin. It is preferable to decide so as to be smaller than that. Specifically, as shown in the figure, when the housing 11 is removed from the skin after the patch 40 has been applied, the double-sided tape 50 has the adhesive layer 46 attached to the skin and the inside of the double-sided tape 50 starting from the outer edge 50a.
- the double-sided tape 50 is preferably attached to a position moved inward by a predetermined distance (indicated by reference numeral 51 in FIG. 6) from both ends of the sheet base material 43 so as to gradually peel from the release treatment layer 47. .
- the double-sided tape 50 can be replaced with an adhesive.
- a protective sheet 55 of a size that closes the opening of the patch accommodating space 41 is affixed to the lower surface of the housing 1 as shown by a dotted line in FIG. Is preferred.
- the size of the protective sheet 55 is preferably substantially the same as the contour of the housing 11.
- the protective sheet 55 is preferably provided with a tab 55 a that is captured by the user when the protective sheet 55 is peeled off from the housing 11.
- a microneedle such as a moisture absorbent or an oxygen absorbent and an agent for suppressing deterioration of the medicine carried thereon may be enclosed.
- the protective sheet 55 attached to the bottom surface of the housing 11 is peeled off to expose the patch 40.
- the applicator is placed on the skin, and the peripheral base 12 of the housing 11 is applied to the skin.
- a finger for example, a thumb
- the applicator 1 is pressed against the skin.
- the raised portion 13 of the housing 11 made of a thin resin sheet or film is deformed.
- the raised portion 13 is folded at the valley fold portion 24, and the dent 25, the finger hold portion 31, and the patch 40 move downward toward the skin.
- the housing 11 is formed of a thin sheet or film, the raised portion 13 is easily deformed downward even with a small pressing force, so that the downward movement of the recess 25 is performed without difficulty.
- the patch 40 advances toward the skin with a small force. Also, after contacting the skin, the patch 40 moves vertically with the skin, and the whole is pressed against the skin with a uniform force. Further, since the needle 49 penetrates vertically into the skin, the needle is not bent, broken or broken at the time of puncture.
- the center portion of the upper member 32 bends downward by a predetermined amount with respect to the both side portions, or the center portion of the lower member 33 is against the both side portions.
- the upper portion 32 and the lower member 33 are deflected downward and upward by a predetermined amount.
- the boss 35 penetrates the through hole 39 of the upper member 32 and the upper surface thereof. It protrudes to a predetermined length and hits the finger pressing the finger holder 31. Thereby, the boss 35 functions as an indicator, and the user can recognize that a necessary force is applied to the finger holder 31.
- the needle 49 of the microneedle patch 40 enters a predetermined amount of skin. As a result, the medicine carried on the needle 49 can be reliably administered to the skin.
- the indentation bottom portion 27 of the raised portion 13 is bent by the easily deformable portion 28, and the lower surface central region 37 of the finger contact lower member 33 and its end region 36 are in the central region 29 of the indentation 25.
- the microneedles 44 that are in contact with the end region (inclined surface) 30 and supported in the central region of the indentation are pressed against the skin with a necessary force.
- sufficient adhesive force between the patch 40 (particularly, the adhesive layer 46) and the skin is greater than the adhesive force between the double-sided tape 50 and the release treatment layer (release layer) 47).
- the housing 11 When the force applied to the finger holder 31 is released, the housing 11 is restored to its original shape by its own elasticity, and the end region of the patch 40 attached to the skin moves away from the skin starting from the edge. Go. Since the lower surface central region 37 and the end region 36 of the finger holder lower member 33 are in contact with the central region 29 and the end region (inclined surface) 30 of the recess 25, the end of the patch 40 is connected to the end region 36. As a result, the peeling force acts on the outer edge of the double-sided tape 50 in a concentrated manner. As a result, the patch 40 is easily peeled off from the double-sided tape 50 in a state where it is attached to the skin and separated from the housing 11.
- the housing 11 of the applicator 1 is made of a material that is relatively easily deformed, it is possible to prevent the raised portion 13 from being deformed and the needle 49 from contacting the protective sheet 55 before use. preferable.
- a deformation preventing member 56 having an outer shape complementary to the back surface shape of the raised portion 13 (that is, the patch housing space 41) is prepared, and this is applied before the protective sheet 55 is attached or It is preferable to store the patch 40 in the patch storage space 41 before the patch 40 is attached.
- the external shape and material of the deformation preventing member 56 are such that even when a predetermined force is applied to the housing 11, the housing is greatly deformed and the needle is prevented from contacting the protective sheet. It is decided.
- the shape of the portion of the deformation preventing member 56 facing the patch is preferably determined so that a space of a predetermined size is formed between the patch and the patch.
- the deformation preventing member 56 of the present embodiment shown in FIG. 7 has a shape complementary to the patch accommodating space 41, the deformation preventing material can take any shape as long as the above-described object can be achieved.
- the patch housing space 41 may be sealed with a protective sheet.
- air may be replaced with an inert gas such as nitrogen or a dry gas in the patch housing space.
- an inert gas such as nitrogen or a dry gas in the patch housing space.
- FIG. 8 shows the housing 111 of the applicator of the second embodiment.
- the housing 111 is formed by, for example, forming a thin resin sheet or film (for example, vacuum forming, pressure forming, press forming) or injecting molten resin into a cavity in a mold ( For example, injection molding).
- the material suitable for molding the housing is preferably a flexible material that can be easily bent, deformed and restored.
- the thickness of each part of the housing is appropriately determined so that a desired deformation described later occurs when a person pushes the housing from above with a finger.
- the thickness of each part is preferably about 50 ⁇ m to 1 mm, more preferably 100 ⁇ m to 500 ⁇ m.
- the housing 111 has a flat plate-shaped peripheral base 112 and a raised portion 113 that is surrounded by the peripheral base 112 and protrudes upward from the peripheral base 112.
- the peripheral base 112 is surrounded by a substantially rectangular outer edge 114.
- the raised portion 113 has a substantially rectangular contour 115 that is substantially similar to the rectangular outer edge 114 of the peripheral base 112.
- the contour 115 includes a pair of long-side contours 116 extending in the long-side direction of the rectangular peripheral base 112 and a pair of short-side contours 117 extending in the short-side direction.
- the raised portion 113 has a substantially quadrangular frustum shape, and has a long side direction side wall 118 and a short side direction side wall 119 extending upward from the long side direction contour portion 116 and the short side direction contour portion 117, respectively.
- the long side wall 118 and the short side wall 119 may be inclined inward.
- each of the side walls 118 and 119 has a slightly inclined lower side wall part and an upper side wall part inclined at a larger inclination angle than the lower side wall part.
- the upper surface 123 of the raised portion 113 is surrounded by a peripheral region 125 and a rectangular or track-shaped recess (center) surrounded by the upper end 120 of the long side direction side wall 118 and the upper end 121 of the short side direction side wall 119. Region) 124.
- the peripheral region 125 surrounding the central region 124 may be a horizontal surface, or an inclined surface inclined upward inward from the long side direction side wall upper end 120 and the short side direction side wall upper end 121, or Any of the inclined surfaces inclined downward may be sufficient.
- valley fold portions 126 extending radially from the corner of the raised portion 113 toward the corner of the central region 124 are formed.
- the valley folding part 126 has a valley bottom 127 that extends horizontally or obliquely upward toward the edge of the central region 124 from almost the boundary between the upper inclined side wall part and the lower inclined side wall part.
- the microneedle patch is housed in the patch housing space formed on the back surface of the raised portion 113 and held on the patch support surface that is the back surface of the central region 124.
- a protective sheet having a size for closing the opening of the patch accommodating space may be attached to the lower surface of the housing 1 (see FIG. 2).
- Easy peel function may be provided so that it can be easily opened by hand.
- the finger holder described in the first embodiment may be provided in the central region 124 of the raised portion 113.
- the applicator and the housing of the second embodiment configured as described above, when the applicator that accommodates the patch is placed on the skin and the central area 124 of the housing or the finger holder disposed therein is pressed, 126 folds around the valley bottom 127, and the raised portion 113 of the housing is deformed downward. As a result, the patch moves downward (skin).
- the housing 111 is formed of a thin sheet or film, the raised portion 113 is easily deformed downward even with a small pressing force.
- the patch travels deeper and perpendicular to the skin with a small force, and the whole is pressed against the skin with a uniform force. Furthermore, since the needle penetrates vertically into the skin, it does not bend, break or break during puncture.
- a deformation preventing member may be provided in the patch housing space, the patch housing space may be sealed with a protective sheet, and / or sealed with a protective sheet. You may enclose compressed gas in a patch accommodation space. Further, the inside of the housing may be filled with a moisture absorbent or an oxygen absorbent, and the housing itself may be made of a moisture absorbent material or may be made of an oxygen absorbent material.
- FIG. 9 shows the housing 211 of the third embodiment.
- the third embodiment is a modification of the second embodiment, and the upper surface central region 224 of the raised portion 213 is a flat surface having no depression.
- Other configurations are the same as those of the second embodiment.
- the applicator that accommodates the patch when the applicator that accommodates the patch is placed on the skin and the center region 224 of the housing or the finger holder disposed therein is pressed, , The valley fold 226 folds around the valley bottom 227, and the raised portion 213 of the housing is deformed downward. As a result, the patch moves downward (skin).
- the housing is formed of a thin sheet or film, the raised portion 213 easily deforms downward even with a small pressing force.
- the patch advances deeper and vertically while pressing the skin with a small force, and the whole is pressed against the skin with a uniform force. Also, since the needle penetrates vertically into the skin, the needle does not bend, break or break during puncture.
- FIG. 10 shows a microneedle patch applicator 300 according to Embodiment 4, and FIGS. 11 and 12 show an applicator housing 301.
- the applicator 300 has a housing 301 that houses a microneedle patch 330 described later.
- the housing 301 is formed by, for example, molding a thin resin sheet or film (for example, vacuum molding, pressure molding, press molding) or by injecting molten resin into a cavity in a mold (for example, injection molding). And has the appearance shown in the figure.
- Resins suitable for molding the housing are, for example, polyethylene, polypropylene, polyethylene terephthalate, polystyrene, nylon, acrylic, silicone, and ABS.
- the thickness of each part of the housing is appropriately determined so that a desired deformation described later occurs when a person pushes the housing 301 from above with a finger.
- the thickness of each part is preferably about 50 ⁇ m to 1 mm, more preferably 100 ⁇ m to 500 ⁇ m.
- the housing 301 includes a flat plate-shaped peripheral base 302 and a raised portion 303 that is surrounded by the peripheral base 302 and protrudes upward (in the z-axis direction in FIG. 11).
- the peripheral base 302 is surrounded by a substantially rectangular outer edge 304.
- the raised portion 303 has a substantially octagonal outline 305 when viewed from above.
- the contour 305 includes a pair of long-side contour portions 306 extending in the long-side direction (x-axis direction in FIG. 11) and a pair of short-side contour portions extending in the short-side direction (y-direction in FIG. 11). 307, and four oblique direction contour portions 308 that intersect the long side direction and the short side direction with a predetermined angle, respectively.
- the raised portion 303 has a caldera basin-shaped flat depression 310 at the center and an outer ring mountain-shaped ridge 311 extending along the outer periphery of the depression 310 and surrounding the depression 310.
- the bottom of the recess 310 is located at a position sufficiently higher than the peripheral base 302, and the housing 301 is placed on the skin, and the back surface of the recess 310 (as will be described later, this back surface is a microneedle patch 330 (FIG. 13). A sufficient space is secured between the skin and the skin.
- the depression 310 has a track-shaped contour having a pair of parallel long side direction edges and a substantially semicircular arc edge connecting the ends thereof.
- the recess 310 is a pair that extends straight in the short-side direction at a position that is a predetermined distance in the long-side direction (x-axis direction) from the central position in the long-side direction (position where the x-axis and y-axis intersect).
- An easily deformable portion (valley folded portion) 312 is formed.
- the easily deformable portion 312 is formed by bending the portion upward, and the end regions 314 located on both sides of the central region 313 sandwiched between the easily deformable portions 312 are easily deformable portions. It is easy to bend upward about 312.
- the ridge portion 311 is formed with a plurality of valley folds that radially traverse the ridge portion 311 from the inside to the outside.
- twelve valley folds 315, 316, and 317 are formed in the ridge portion 311.
- the twelve valley folds 315, 316, and 317 are formed symmetrically with respect to the vertical axis (z axis), the long axis (x axis), and the short axis (y axis) passing through the center of the recess 310, respectively.
- the boundary between each long side direction contour portion 306 and two oblique direction contour portions 308 adjacent thereto is radially arranged so that the distance between the valley portions gradually increases from the inside toward the outside.
- Two first valley folds 315 are formed. At the boundary between each short side direction contour portion 307 and the two diagonal direction contour portions 308 adjacent thereto, two radially arranged so that the distance between the valley fold portions gradually increases from the inside toward the outside. A second valley fold 316 is formed. One third valley fold 317 is formed at the center of each oblique contour 308.
- the valley bottom 318 of the first valley fold 315, the valley bottom 319 of the second valley fold 316, and the valley bottom 320 of the third valley fold 317 are horizontal valley bottoms extending in the horizontal direction parallel to the peripheral base 302. Or a sloped valley bottom that slopes to the lower peripheral base.
- the valley folds should be provided at a plurality of locations where deformation is expected to occur in the housing without the valley folds when a force is applied to the housing without the valley folds via the finger rests (pressing parts) 322. Is preferred. As a result, the housing can be deformed into a desired shape even with a weak force, and a stable deformation of the housing can be obtained.
- the valley fold is preferably shaped to promote the deformation of the housing. Therefore, it is preferable to change the angle of the valley bottom, the shape and size of the valley fold, etc. according to the shape of the raised portion. As a result, the housing can be deformed into a desired shape even with a weak force, and a stable deformation of the housing can be obtained.
- the housing 311 is formed by molding with a thin sheet or film.
- a microneedle patch accommodating space (recess) having a shape corresponding to the raised portion 303 is provided behind the raised portion 303. 321 is formed.
- a patch support surface 331 is formed on the back surface of the recess 321.
- the patch support surface 331 has a central region 340 and an end region 341 corresponding to the back side of the central region 313 and the end region 314 of the recess 321.
- the patch 330 is disposed on the patch support surface 331, the microneedle array 344 is supported by the central region 340, and the double-sided tape 350 is supported by the both end regions 341.
- the double-sided tape 350 can be replaced with an adhesive.
- the valley bottom 320 of the third valley fold 317 extends obliquely downward from the inside toward the outside, so that the deformation toward the inside of the raised portion 303 ( This simultaneously involves a vertical deformation to the base.)
- the resistance of the housing 301 is reduced. Therefore, the bulging portion 303 advances the patch 330 vertically toward the skin while deforming inward so that the entire bulging portion contracts.
- the patch 330 advances deeper and perpendicularly to the skin with a small force, and the whole is pressed against the skin with a uniform force. Also, since the needle penetrates vertically into the skin, the needle does not bend, break or break during puncture.
- FIG. 16 shows a housing 501 of an applicator according to the fifth embodiment.
- the protruding portion 503 has a substantially octagonal shape when viewed from above, and its outline 505 includes a long-side outline portion 506 in the long-side direction, a short-side outline portion 507 in the short-side direction, and an oblique direction.
- a directional contour 508 is formed.
- the ridge portion 511 includes valley folds 515, 516 at respective locations corresponding to the boundaries of the long side contour portion 506 in the long side direction, the short side contour portion 507 in the short side direction, and the contour portion 508 in the oblique direction. Is formed.
- the valley bottom of the valley fold 515 is inclined downward toward the peripheral base.
- the valley bottom of the valley fold 516 may be inclined downward toward the peripheral base, or may be horizontal in parallel with the peripheral base.
- the valley bottom of the valley fold 515 is deformed while moving in an inner direction perpendicular to the valley 515, so that the vertical progression of the recess 510 and the patch is improved. Therefore, the patch travels perpendicular to the skin and the whole is pressed against the skin with a uniform force. Also, since the needle penetrates vertically into the skin, the needle does not bend, break or break during puncture.
- FIG. 17 shows an applicator housing 601 according to the sixth embodiment.
- the raised portion 603 has a substantially octagonal shape when viewed from above, and its contour 605 includes a long-side contour portion 606 in the long-side direction, a short-side contour portion 607 in the short-side direction, and an oblique direction. It is constituted by a contour portion 608 in the direction, and valley fold portions 615 and 616 are formed at boundary portions between adjacent contour portions 605, 606 and 607. The valley bottoms of the valley folding portions 615 and 616 are inclined downward from the inside toward the outside.
- the downward deformation direction of the valley folds 615 and 616 having inclined valley bottoms is symmetric with respect to the vertical plane including the major axis and the minor axis of the depression 610, and Since it is directed diagonally inward, the indentation 610 and the patch supported on its back surface proceed perpendicular to the indentation 610. As a result, the patch travels perpendicularly and deeper to the skin, and the whole is pressed against the skin with a uniform force. In addition, since the needle penetrates the skin vertically, the needle is not bent, broken or broken during puncture.
- the inclination angle of the valley bottom of the valley fold portion 615 located on both sides of the long side direction contour portion 606 is the same as the inclination angle of the valley bottom of the valley fold portion 616 located on both sides of the short side direction contour portion 607. Either one may be larger than the other.
- Embodiment 7 In the sixth embodiment, the valley bottoms of all the valley folds are inclined downward from the inside to the outside of the ridges. However, as shown in FIG. 18, the valley bottoms of all the valley folds 715, 716 are set to the peripheral bases. May be parallel to the horizontal direction, or one of the valley folds 715 or 718 may be inclined and the other horizontal.
- Embodiment 8 In the above embodiment, the contour of the raised portion of the housing is a polygon, but the contour of the raised portion 803 may be circular as shown in FIG.
- the raised portion 803 of the housing 801 may be provided with a plurality of valley fold portions 811 extending radially from the center of the recess 810 at equal intervals in the circumferential direction, or perpendicular to the center of the raised portion.
- a plurality of valley folds may be arranged rotationally symmetrically about the axis.
- the planar shape of the housing raised portion is not limited, and may be a polygon such as a quadrangle, a pentagon, and a hexagon, or a circle, an ellipse, or a track.
- the valley fold portion having the inclined valley bottom and the valley fold portion having the inclined valley bottom are symmetrical with respect to the vertical plane including the major axis or the minor axis of the raised portion.
- the valley folds having inclined valley bottoms at equal intervals in the circumferential direction around the vertical axis.
- the valley fold having an inclined valley bottom has two axes (orthogonal horizontal axes X and Y) perpendicular to the central axis (vertical axis Z). They may be arranged symmetrically with respect to at least one of them, or may be arranged in a central object with respect to the central axis.
- the shape of the indentation and the corresponding finger holder is not limited to the track shape, and may be any of an ellipse, a circle, a rectangle, and other polygons.
- the ridge portion 111 does not need to be continuously arranged around the recess, and may be discontinuous.
- the patch is pressed against the skin through the finger holder, but the depression may be directly pressed with the finger without using the finger holder.
- the depression of the raised portion is not necessarily required, and the top of the raised portion may be a flat surface without a depression.
- the valley fold is formed on the outer periphery of the raised portion. The number of the valley folds and the inclination angle of the valley bottom are appropriately selected so as to ensure the vertical puncture property of the needle.
- the thin member 851 is formed in the upper member 32 at a location facing the boss 35 of the lower member 33, The boss 35 may deform or destroy the thin portion 851 when a necessary force is applied to the portion.
- the thin portion 851 functions as an indicator for notifying the operator that a predetermined pressing force has been applied to the finger holder.
- An indicator for notifying the operator that a predetermined pressing force has been applied to the finger holder is, for example, a specific indicator formed on each of the upper member and the lower member when the predetermined pressing force is applied to the finger holder.
- the shape portions may be in contact with or separated from each other, or a specific shape portion provided on one of the upper member and the lower member may be destroyed to generate sound (contact sound, destruction sound).
- a hole or the like is provided in one of the upper member or the lower member, and a protrusion that snap-fits to the other is provided in the other, so that a click feeling can be obtained or a sound can be generated by fitting these together. May be.
- the curved surface is slightly convex downward.
- the structure may be such that a metal or resin is deformed such as a dome spring which is a configured circular plate so that sound or vibration is generated.
- FIG. 21 shows an applicator 1000 according to the ninth embodiment.
- the applicator 1000 has a housing 1001 and a pressing mechanism 1015.
- the housing 1001 has a peripheral base 1002 as in the above-described embodiment.
- a bracket-shaped notch 1012 is formed in the long side direction edge portion 1011 of the peripheral base portion 1002.
- an arch-shaped notch 1014 is formed in the short side direction edge portion 1013 of the peripheral base portion 1002.
- the housing 1001 is substantially the same as the housing 301 of the fourth embodiment. Therefore, detailed description of the housing 1001 is omitted. Further, in the following description, for each part of the housing 1001, reference numerals in the 900s, which are obtained by adding 600 to the reference numerals assigned to the corresponding parts of the housing of the fourth embodiment, are used as appropriate.
- the pressing mechanism 1015 generally has an upper structure 1016 and a lower structure 1017.
- the upper structure 1016 has an elastic extension portion 1018 having a substantially inverted U shape or a substantially inverted arch shape.
- the elastic extension portion 1018 is made of, for example, an elastic synthetic resin. Therefore, when a force is applied to the central portion of the elastic extension portion 1018 from above, both end portions 1019 of the elastic extension portion 1018 can be deformed so as to move outward while being separated from each other.
- both end portions 1019 of the elastic extension portion 1018 are formed in a substantially cylindrical shape. In the free state, the distance between the left and right end portions 1019 is the same as or slightly larger than the distance between the pair of bracket-shaped notches 1012 formed in the long side direction edge portion 1011 of the housing 1001.
- a substantially rectangular opening 1020 that penetrates the upper surface and the lower surface is formed in the central region of the elastic extension portion 1018.
- a pair of grooves 1021 are formed on the upper surface of the elastic extension portion 1018 so as to extend straight outward from the diagonally opposite corners of the opening 1020 toward both end portions 1019.
- a torsion spring 1022 is accommodated in the opening 1020 and the groove 1021.
- the torsion spring 1022 has a winding portion 1023 wound with a wire and a pair of arm portions 1024 extending straight from both ends of the winding portion 1023.
- the winding portion 1023 is accommodated in the opening 1020
- the arm portion 1024 is accommodated in the groove 1021, and held by the elastic extension portion 1018 by the pin 1025.
- the pin 1025 is engaged with the lower center surface of the elastic extension portion 1018, whereby the winding portion 1023 is retracted from the position indicated by the solid line to the position indicated by the dotted line in FIG. Is held in the opening 1020, and the elastic portion 1018 is urged by the arm portion 1024 so that both end portions 1019 thereof are close to each other.
- a groove 1026 in the width direction is formed in the center of the lower surface of the elastic extension portion 1018, and the pin 1025 is accommodated in the groove 1026.
- a finger holding part 1027 is assembled to the elastic extension part 1018.
- the finger holding unit 1027 includes an upper part 1028 on which a user presses a finger (for example, a thumb) and a pair of leg parts 1029 extending downward from the lower surface of the upper part 1028. Each leg 1029 has an engaging portion 1030 at its lower end.
- the finger holding part 1027 configured as described above is such that the winding part 1023 of the torsion spring 1022 is positioned between the leg parts 1029 and the leg part 1029 is inserted into the opening 1020 downward from above to form an elastic extension part. 1018.
- the connecting member 1031 is engaged and held by the lower end engaging portion 1030 of the leg portion 1029 protruding downward from the opening 1020.
- the connecting member 1031 is a substantially circular member, and an engaged portion 1032 having a shape corresponding to the lower end engaging portion 1030 is formed at a symmetrical portion on the upper surface.
- the lower end engaging portion 1030 of the leg portion 1029 is connected to the engaged portion.
- the finger holder 1027 is connected to the connecting member 1031 by being inserted into 1032 and engaged therewith.
- the lower structure 1017 includes an upper member 1033 and a lower member 1034 as shown in FIG.
- the upper member 1033, the lower member 1034, and particularly the lower member 1034 have a track shape that is substantially the same size as the recess 910 of the housing 1011 when viewed from above.
- a base portion 1035 protruding downward is formed at both ends in the long side direction.
- Each pedestal portion 1035 has a claw portion 1036 extending in the width direction at both ends in the long side direction, and a protrusion 1037 protruding downward at the center edge portion.
- a cylindrical boss 1038 is formed at the center of the lower surface of the upper member 1033.
- the lower end portion 1039 of the cylindrical boss 1038 has a slightly larger diameter than the other portions. Further, the cylindrical boss 1038 is formed with a longitudinal cross groove 1040 extending in the long side direction and the short side direction of the upper member 1033 from the lower end surface upward along the central axis. Deformable so that its outer diameter becomes smaller when force is applied
- the lower member 1034 as a whole is formed by a central plate portion 1041 and an inclined plate portion 1042 extending obliquely upward from both ends of the central plate portion 1041.
- a through hole 1043 is formed in the center of the central plate portion 1041 so as to penetrate the upper and lower surfaces of the central plate portion 1041.
- An annular ridge (projection) 1045 is formed at the upper end of the inner surface of the through hole 1043.
- the inner diameter of the through-hole 1043 excluding the annular ridge portion 1045 is substantially equal to the outer diameter of the cylindrical boss large diameter lower end portion 1039, and the inner diameter of the annular ridge portion 1045 is slightly smaller than the outer diameter of the cylindrical boss large diameter lower end portion 1039.
- the central plate portion 1041 may be formed with a plurality of fan-shaped grooves arranged around the through hole 1043 so as to surround the through hole 1043.
- the vertical cross groove 1040 may not be formed.
- the inclined plate portion 1042 of the lower member 1034 is formed with engaging grooves 1047 having shapes corresponding to the claw portions 1036 of the upper member 1033 on both ends of the upper surface, and the upper member 1033 is placed on the lower member 1034. , The claw portion 1036 of the upper member 1033 is engaged with the engaging groove 1047 of the lower member 1034 to hold the lower member 1034.
- the end of the inclined plate portion 1042 of the upper member 1033 is formed with a longitudinal cut 1048 at the center thereof, and the upper member 1033 is placed in the recess 104 of the lower member 1034 with the upper member 1033 placed on the lower member 1034.
- the protrusion 1037 of 1033 is engaged, and the movement of the upper member 1033 in the width direction relative to the lower member 1034 is restricted.
- the pressing mechanism 1015 configured as described above is assembled to the housing 1001 as shown in FIGS. Specifically, the lower structure 1017 is disposed in the central recess 910 of the housing 1001. The upper structure 1016 engages both end portions 1019 of the elastic extension portion 1018 with the long-side notch 1012 of the housing 1001 and holds the housing 1017 between the both end portions 1019. At this time, the user can combine the upper structure 1016 and the housing 1001 while holding and holding the thumb and index finger on the notch 1014 of the housing 1001.
- the elastic extension portion 1018 is urged by the torsion spring 1022 in a direction in which both end portions 1019 face each other, so that the housing 1001 is stably supported between the both end portions 1019.
- the lower surface of the connecting member 1031 is in contact with the upper surface of the finger contact portion 1027, and the housing 1001 is stably supported by the pressing mechanism 1015.
- the protective sheet attached to the bottom surface of the housing 1011 is peeled off as described above to expose the patch.
- the applicator 1000 is placed on the skin, and the peripheral base of the housing 1011 is applied to the skin. At this time, both end portions 1019 of the elastic extension portion 1018 are in contact with the skin.
- the finger is pressed toward the skin while a finger (for example, a thumb) is applied to the finger holder 1027 of the pressing mechanism 1015.
- a finger for example, a thumb
- the elastic extension portion 1018 moves outward while the center portion thereof moves downward while both end portions 1019 are in contact with the skin.
- the skin in the region where the microneedle patch faces is pulled in the opposite direction. Therefore, tension is applied to the skin, and the microneedle is easily stuck into the skin later. That is, the skin is stretched, resists pressure from a direction perpendicular to the skin surface, and can develop a certain stress.
- Both end portions 1019 may be formed with irregularities and grooves that increase friction with the skin, or may be provided with an adhesive or the like.
- the lower structure 1017 deforms the housing 1011 while pushing the indentation center region 913 of the housing 1011.
- the inclined plate portion 1042 of the lower member 1034 is in contact with the indentation end region, and the microneedles supported in the indentation center region are strongly pressed against the skin.
- the central portion of the upper member 1033 in the lower structure 1017 bends downward by a predetermined amount with respect to both side portions thereof, or the central portion of the lower member 1034 is
- the upper portion 1033 and the lower member 1034 are deflected downward and upward by a predetermined amount, and as a result, the cylindrical boss 1038 of the upper member 1033 enters the through hole 1043 of the lower member 1034.
- the lower end portion 1039 of the cylindrical boss 1038 gets over the raised portion 1045 of the lower member 1034, and the lower end portion 1039 of the cylindrical boss 1038 is raised on the inner surface of the through hole.
- the part (projection) 1045 Engage with the part (projection) 1045.
- the engagement between the lower end portion 1039 and the raised portion 1045 is sensed by the user through tactile sensation or sound through a finger in contact with the finger contact portion 1027. Therefore, the user can recognize that a predetermined force has been applied to the finger holder 1027. Further, when a predetermined force is applied to the finger holder 1027, the needle of the microneedle patch enters the skin by a predetermined amount. As a result, the drug carried on the needle is reliably administered to the skin.
- the cylindrical boss lower end portion 1039 and the raised portion 1045 corresponding thereto function as an indicator that allows the user to sense that a predetermined force has been applied to the finger holding portion 1027.
- the pressing mechanism 1015 and the housing 1001 may be engaged by the user before use.
- the positioning may be performed during use on the skin by using both ends 1019 of the elastic extension portion 1018 and the long side direction notch 1012 of the housing 1001 without being engaged, or by confirming the position visually. May be.
- FIG. 25 [FIG. 25 (a), (b)] shows the applicator 1100 of the tenth embodiment.
- a connecting structure 1051 for connecting the connecting member 1031 to the lower structure 1017 is formed on the connecting member 1031 of the upper structure 1016 in the pressing mechanism 1015.
- the connection structure 1051 includes a pair of engagement claws 1052 that are arranged symmetrically with respect to the central axis in the vertical direction of the connection member 1031.
- the interval between the engaging claws 1052 is designed to be substantially equal to the width in the short direction of the lower structural upper member 1033 in the pressing mechanism 1015, and the entire lower structure 1017 is held by the upper structure 1016 by the engaging claws 1052. is there.
- Other configurations are substantially the same as those of the ninth embodiment. Therefore, the same members or the same parts are denoted by the same reference numerals, and description thereof is omitted.
- the pressing mechanism 1015 can be easily assembled to the housing 1001 in a state where the upper structure 1016 and the lower structure 1017 of the pressing mechanism 1015 are integrated.
- Embodiment 11: 26 and 27 show an applicator 1200 according to the eleventh embodiment.
- the applicator 1200 has a housing 1201 and a pressing mechanism 1215.
- the housing 1201 has a peripheral base 1202 as in the ninth embodiment.
- a bracket-shaped notch 1212 is formed in the long side direction edge portion 1211 of the peripheral base portion 1202. Except for this point, the housing 1201 is substantially the same as the housing 301 of the fourth embodiment. Therefore, detailed description of the housing 1201 is omitted. Further, in the following description, for each part of the housing 1201, reference numerals in the 900s, which is obtained by adding 600 to the reference numerals assigned to the corresponding parts of the housing of the fourth embodiment, are used as appropriate.
- the pressing mechanism 1215 generally has an upper structure 1216 and a lower structure 1217.
- the upper structure 1216 has an elastic extension portion 1218 having a substantially inverted U shape or a substantially inverted arch shape.
- the elastic extension portion 1218 is made of, for example, a synthetic resin having elasticity. Therefore, when a force is applied to the central portion of the elastic extension portion 1218 from above, both end portions 1219 of the elastic extension portion 1218 can be deformed so as to move outward while being separated from each other.
- both end portions 1219 of the elastic extension portion 1218 are formed in a substantially cylindrical shape. In the free state, the distance between the left and right end portions 1219 is the same as or slightly larger than the distance between the pair of bracket-shaped notches 1212 formed in the long side direction edge portion 1211 of the housing 1201.
- a substantially rectangular opening 1220 that penetrates the upper surface and the lower surface is formed in the central region of the elastic extension portion 1218.
- a pair of grooves 1221 are formed on the upper surface of the elastic extension portion 1218 so as to extend straight outward from the diagonally opposite corners of the opening 1220 toward both end portions 1219.
- a torsion spring 1222 is accommodated in the opening 1220 and the groove 1221.
- the torsion spring 1222 has a wound part 1223 wound with a wire and a pair of arm parts 1224 extending straight from both ends of the wound part 1223.
- the winding portion 1223 is accommodated in the opening 1220
- the arm portion 1224 is accommodated in the groove 1221, and is held by the elastic extension portion 1218 by the pin 1225.
- the pin 1225 is engaged with the lower center surface of the elastic extension 1218, whereby the winding portion 1223 is held in the opening 1220 in a state where the arm opening angle of the torsion spring 1222 is reduced. 1218 is urged so that its both ends 1219 approach each other.
- a groove 1226 in the width direction is formed at the center of the lower surface of the elastic extension portion 1218, and the pin 1225 is accommodated in the groove 1226.
- a finger holding part 1227 is assembled to the elastic extension part 1218.
- the finger holding unit 1227 includes an upper part 1228 on which a user presses a finger (for example, a thumb) and a pair of legs 1229 extending downward from the lower surface of the upper part 1228. Each leg 1229 has an engaging portion 1230 at its lower end.
- the finger holding part 1227 configured as described above has the leg part 1229 inserted through the opening 1220 downward from above the elastic part 1218 so that the winding part 1223 of the torsion spring 1222 is sandwiched between the leg parts 1229. Assembled into.
- the connecting member 1251 is engaged and held by the lower end engaging portion 1230 of the leg portion 1229 protruding downward from the opening 1220.
- the connecting member 1251 is a member having an inverted pan shape (a shape in which the pan is turned upside down) having a cylindrical wall 1252 having a central axis in the vertical direction and a ceiling wall 1253 connected to the upper end of the cylindrical wall 1252.
- the to-be-engaged portion 1254 having a shape corresponding to the finger rest lower end engaging portion 1230 is formed on the ceiling wall 1253 so as to be axially symmetric, and the finger rest lower end engaging portion 1230 is inserted into the engaged portion 1254. By engaging, the finger holder 1227 is connected to the connecting member 1251.
- An opening 1255 having an inverted truncated cone shape (a shape in which the diameter gradually increases from the inner end portion toward the outer end portion) is formed in the center of the ceiling portion 1253.
- the opening 1255 accommodates a deformable member 1256 made of a circular plate portion and a dish-shaped thin metal plate obtained by processing the periphery of the circular plate portion into an inverted truncated cone shape.
- the opening edge has a shape corresponding to the peripheral inverted truncated cone shape of the deformation member 1256 as described above.
- the circular plate portion of the deformation member 1256 has a convex curved surface slightly downward. For example, when the central portion of the circular plate portion is pressed upward from below, the convex curved surface directed downward is formed. It is configured to warp to a concave curved surface and generate sound or vibration.
- a pressing member 1257 is disposed on the deformable member 1256 and fixed to the connecting member 1251.
- the pressing member 1257 is fixed to the connecting member 1251 by, for example, engaging an engaging protrusion formed on the pressing member 1257 with an engaged portion formed on the connecting member 1251 corresponding to the engaging protrusion. Can do.
- the connecting member 1251 is also provided with a pair of engagement holes 1257 penetrating the upper surface (outer surface) and the lower surface (inner surface) in the axially symmetrical portion of the ceiling wall 1253 to hold the elevating member 1261 described below. Yes.
- the elevating member 1261 is a pan-shaped member having a cylindrical wall 1262 having a central axis in the vertical direction and a bottom wall 1263 connected to the lower end of the cylindrical wall 1262.
- the outer diameter of the elevating member cylindrical wall 1262 is smaller than the inner diameter of the connecting member cylindrical wall 1252.
- the raising / lowering member cylindrical wall 1262 has a pair of engaging portions 1264 formed at the upper end edge thereof in axial symmetry, and the raising / lowering member bottom wall 1263 has a column 1265 extending upward at the center of the upper surface thereof.
- the elevating member 1261 configured in this way accommodates the coil spring 1266 inside, inserts the elevating member cylindrical wall 1262 into the connecting member cylindrical wall 1253 from below, and forms the engaging portion 1264 on the inner wall of the connecting member 1251.
- the grooves and protrusions are engaged so as to be movable up and down, and combined.
- the axial (longitudinal) length of the coil spring 1266 is such that the coil spring 1266 is compressed between the ceiling wall 1253 and the bottom wall 1263 in a state where the connecting member 1251 and the elevating member 1261 are combined.
- the elevating member 1261 is determined to be biased and held at the lowest position (the lowest position).
- the length of the column 1265 of the elevating member 1261 is such that the connecting member 1251 and the elevating member 1261 are combined, and the elevating member 1261 is at the lowest lowered position with respect to the connecting member 1251 by the coil spring 1266, and the upper end of the column 1265 is the deforming member. It is determined so that the center part of 1256 may touch lightly or not.
- the lower structure 1217 has a rectangular plate 1271 having substantially the same size as the indentation central region 913 of the housing 1201. On the upper surface of the plate 1271, at least one protrusion 1272 is formed in the central region, and engaging portions 1273 are formed at opposite edges located on both sides of the protrusion 1272.
- the plate 1271 having such a structure engages the protrusion 1272 and the engaging portion 1273 with the corresponding hole (not shown) formed in the elevating member bottom wall 1263 and the engaged member 1274, respectively.
- the protective sheet attached to the bottom surface of the housing 1211 is peeled off to expose the patch. Since the protective seal has an easy peel function, it can be easily peeled off.
- the applicator 1200 is placed on the skin, and the peripheral base of the housing 1211 is applied to the skin. Alternatively, when attaching the microneedle patch, the protective sheet attached to the bottom surface of the housing 1211 is peeled off to expose the patch. Since the protective seal has an easy peel function, it can be easily peeled off.
- the housing 1211 may be connected to the upper structure 1216 by the lower structure 1217, the applicator 1200 may be placed on the skin, and the periphery of the housing 1211 may be applied to the skin.
- the housing 1211 is connected to the upper structure 1216 by the lower structure 1217, and then the protective sheet attached to the bottom surface of the housing 1211 is peeled off to expose the patch. Thereafter, the applicator 1200 may be placed on the skin and the periphery of the housing 1211 may be applied to the skin.
- the pressing mechanism 1215 may engage the plate 1271 of the lower structure 1217 against the recess 910 of the housing 1201, and position both end portions 1219 of the elastic extension portion 1218 at the notches 1212 in the long side direction of the housing 1201. .
- both end portions 1219 of the elastic extension portion 1218 are in contact with the skin.
- the finger is pressed toward the skin while applying a finger (for example, a thumb) to the finger holder 1227 of the pressing mechanism 1215.
- a finger for example, a thumb
- the elastic extension portion 1218 moves outward while the central portion thereof moves downward and both end portions 1219 are in contact with the skin.
- the skin in the region where the microneedle patch faces is pulled in the opposite direction. Therefore, tension is applied to the skin, and the microneedle is easily stuck into the skin later.
- the plate 1271 of the lower structure 1217 pushes the indentation central region 913 of the housing 1211 and deforms the housing 1211.
- the microneedles supported in the central region of the indentation are strongly pressed against the skin.
- the elevating member 1261 rises with respect to the connecting member 1251, and the pillar 1265 pushes the central portion or the central peripheral portion of the deformable member 1256 from below.
- the deformable member 1256 is deformed from a convex state downward to a concave state downward, and generates an impact and sound. This impact is sensed by the user through the finger placed on the finger holder 1227. Therefore, the user can recognize that a predetermined force has been applied to the finger holder 1227.
- the needle of the microneedle patch enters the skin by a predetermined amount. As a result, the drug carried on the needle is reliably administered to the skin. In this manner, the deformable member 1256 functions as an indicator that allows the user to sense that a predetermined force has been applied to the finger holder 1227.
- the elevating member 1261 and its column 1265 are returned to the lowered position by the urging force of the coil spring 1266.
- the deformable member 1256 returns from the concave shape downward to the convex shape due to its own elastic recovery force.
- the return of the deformable member 1256 to the convex state downward is sensed by the user through a finger placed on the finger holder 1227 by sound and impact. Therefore, the user can recognize that the predetermined force is not continuously applied to the finger holder 1227.
- the necessary amount of medicine can be reliably administered to the skin.
- This predetermined time is described in the instruction manual of the applicator 1200, for example, so that a predetermined amount of medicine can be reliably administered to the skin.
- the plate 1271 of the lower structure 1217 is attached to the lower surface of the elevating member 1261 and the housing 1201 is deformed via this plate 1271, but as shown in FIGS.
- the recess central portion 913 of the housing 1201 may be pressed directly at 1261 to be deformed.
- the elastic extension part 1218 of the pressing mechanism 1215 can control the spreading force by the elasticity of the elastic extension part itself and / or the elasticity of the torsion spring, and as a result, the force for spreading the skin can be made constant. If the skin is spread and tension is applied, the microneedles can be easily inserted, but the skin condition varies depending on the skin site or individual. By making the force of spreading the skin constant by this method, the difference between the parts and individuals can be reduced, and the microneedle can be inserted into the skin with high accuracy.
- the torsion spring is exemplified as the means for urging the elastic extension portion, but an elastic body such as a coil spring or rubber, or a foam may be used instead of the torsion spring.
- the applicator of the present disclosure may be hermetically packaged with a packaging material having excellent light shielding properties such as an aluminum laminate pouch.
- a packaging material having excellent light shielding properties such as an aluminum laminate pouch.
- microneedles such as a moisture absorbent and an oxygen absorbent and an agent for suppressing deterioration of the medicine carried thereon may be enclosed.
- Microneedle Patch Applicator 11 Housing 12: Peripheral Base 13: Raised Part 14: Outer Edge 15: Contour 16: Long Side Direction Contour 17: Short Side Direction Contour 18: Long Side Direction Side Wall 19: Short Side Direction Side Wall 20: upper end 21 of the long side direction side wall 21: upper end 22 of the short side direction side wall 22: long side direction inclined upper surface part 23: short side direction inclined upper surface part 24: boundary / valley folded part 25: depression 26: peripheral wall part 27: bottom part 28: Easy deformation part 29: Central area 30: End part area 31: Finger holding part 32: Upper member 33: Lower member 34: Support part 35: Boss 36: End part area (inclined surface) 37: Central region 38: Protruding part 39: Through hole 40: Microneedle patch 41: Patch accommodating space 42: Patch support surface 43: Sheet substrate 44: Microneedle array 45: Substrate film 46: Adhesive layer 47: Peeling Treatment layer (release layer) 48: Base layer 49: Needle 50: Double-sided tape 55:
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Abstract
Description
上面と下面を有する一枚のシート又はフィルムで構成されており,平坦な周辺基部と,前記周辺基部に囲まれて前記周辺基部に対して前記下面から前記上面に向かう垂直上方に膨出した隆起部を有するハウジングを備えており,
前記隆起部の下面部分がマイクロニードルパッチを支持する面を構成しており,
前記隆起部は複数の谷折部を備えており,
前記谷折部は前記隆起部の中心部から離れる方向に向けた谷底を有する。
上述したいずれかのマイクロニードルパッチアプリケータ用ハウジングと,
前記マイクロニードルパッチを支持する面に支持されたマイクロニードルパッチとを備えている。
前記ハウジングの周辺基部の下面に保護シートが貼り付けられており,
前記保護シートが,前記隆起部の背後に形成されたマイクロニードルパッチ収容空間の開口を塞いでいる。
図1は実施形態1に係るマイクロニードルパッチアプリケータ(以下,「アプリケータ」という。)1を示す。
図8は実施形態2のアプリケータのハウジング111を示す。ハウジング111は,実施形態1と同様に,例えば薄い樹脂のシート又はフィルムを成形(例えば,真空成形,圧空成形,プレス成形)するか,溶融した樹脂を金型内のキャビティに射出して成形(例えば,射出成形)されている。ハウジングの成形に適した材質は,柔軟性があり容易に曲り,変形し,また復元するような材質が望ましく,例えば,ポリエチレン,ポリプロピレン,ポリエチレンテレフタラート,ポリスチレン,ナイロン,アクリル,シリコーン,ABSなどの樹脂が挙げられる。ハウジングの各部の厚さは,人が指でハウジングを上から押したときに,後述する所望の変形が起こるように適宜決定される。例えば,ポリエチレン,ポリプロピレン,ポリエチレンテレフタラートからなるハウジングの場合,各部の厚さは,好ましくは約50μmから1mm,更に好ましくは100μmから500μmである。
図9は実施形態3のハウジング211を示す。この実施形態3は実施形態2の改変例で,隆起部213の上面中央領域224はくぼみの無い平面である。その他の構成は実施形態2と同じである。
図10は実施形態4に係るマイクロニードルパッチアプリケータ300を示し,図11と図12はアプリケータ用ハウジング301を示す。
図16は,実施形態5に係るアプリケータのハウジング501を示す。ハウジング501において,隆起部503はこれを上方から見たとき略八角形をしており,その輪郭505は長辺方向の長辺輪郭部506と,短辺方向の短辺輪郭部507と,斜め方向の輪郭部508によって構成されている。そして,尾根部511には,長辺方向の長辺輪郭部506,短辺方向の短辺輪郭部507,及び斜め方向の輪郭部508の境界に対応するそれぞれの箇所に谷折部515,516が形成されている。谷折部515の谷底は周辺基部に向けて下方に傾斜させてある。谷折部516の谷底は周辺基部に向けて下方に傾斜させてもよいし,周辺基部と平行に水平であってもよい。
図17は,実施形態6に係るアプリケータのハウジング601を示す。ハウジング601において,隆起部603はこれを上方から見たとき略八角形をしており,その輪郭605は長辺方向の長辺輪郭部606と,短辺方向の短辺輪郭部607と,斜め方向の輪郭部608によって構成され,隣接する輪郭部605,606,607の境界部分に谷折部615,616が形成されている。谷折部615,616の谷底は内側から外側に向かって下方に傾斜させてある。
実施形態6では,すべての谷折部の谷底が,隆起部の内側から外側に向かって下方に傾斜させたが,図18に示すように,すべての谷折部715,716の谷底を周辺基部と平行に水平方向に向けてもよいし,谷折部715又は718の一方を傾斜させて他方を水平に向けてもよい。
以上の実施形態では,ハウジングの隆起部の輪郭は多角形としたが,図19に示すように,隆起部803の輪郭を円形にしてもよい。この実施形態では,ハウジング801の隆起部803には,くぼみ810の中心から放射方向に伸びる複数の谷折部811を周方向に等間隔に配置してもよいし,隆起部の中心と通る垂直軸を中心として複数の谷折部を回転対称に配置してもよい。本実施形態8のハウジングでも,上述の実施形態と同様に,くぼみ810には少なくとも2つの易変形部812を平行に設けることが好ましい。
以上の実施形態において,ハウジング隆起部の平面形状は限定的ではなく,四角形,五角形,六角形等の多角形でもよいし,円形又は楕円形若しくはトラック形状であってもよい。いずれの形態においても,谷底が傾斜した谷折部及び傾斜した谷底を有する谷折部は隆起部の長軸又は短軸を含む垂直面に対して対称であることが好ましい。また,五角形等の奇数個の辺を有する多角形の場合,傾斜した谷底を有する谷折部は垂直軸を中心とする周方向に等間隔に配置することが好ましい。なお,円形隆起部については長軸と短軸を区別できないが,谷底が傾斜した谷折部は,中心軸(上下方向の軸Z)に直交する2つの軸(直交する水平軸X,Y)の少なくとも一つに関して対称に配置してもよいし,中心軸に対して中心対象に配置してもよい。
図21は,実施形態9のアプリケータ1000を示す。アプリケータ1000は,ハウジング1001と押圧機構1015を有する。
両端部1019は,皮膚との摩擦を増やすような凸凹や溝を形成してもよく,粘着剤などを設置してもよい。
図25〔図25(a),(b)〕は,実施形態10のアプリケータ1100を示す。アプリケータ1100において,押圧機構1015における上部構造1016の連結部材1031には,この連結部材1031を下部構造1017に連結する連結構造1051が形成されている。実施形態において,連結構造1051は,連結部材1031の上下方向中心軸に関して対称に配置された一対の係合爪1052を有する。係合爪1052の間隔は,押圧機構1015における下部構造上部材1033の短片方向幅とほぼ等しく設計されており,係合爪1052によって下部構造1017の全体が上部構造1016に保持されるようにしてある。その他の構成は実施形態9と実質的に同じである。したがって,同一部材又は同一部分には同一の符号を付して説明を省略する。
図26,27は,実施形態11のアプリケータ1200を示す。アプリケータ1200は,ハウジング1201と押圧機構1215を有する。
或いは,マイクロニードルパッチの貼り付け時,ハウジング1211の底面に貼り付けられた保護シートを剥がし,パッチを露出させる。保護シールはイージーピール機能を有するので容易に剥離できる。次にハウジング1211を下部構造1217によって上部構造1216と連結し,アプリケータ1200を皮膚に載せ,ハウジング1211の周辺部を皮膚に当ててもよい。
または,マイクロニードルパッチの貼り付け時,ハウジング1211を下部構造1217によって上部構造1216と連結し,次にハウジング1211の底面に貼り付けられた保護シートを剥がし,パッチを露出させる。その後,アプリケータ1200を皮膚に載せ,ハウジング1211の周辺部を皮膚に当ててもよい。
11:ハウジング
12:周辺基部
13:隆起部
14:外縁
15:輪郭
16:長辺方向輪郭部
17:短辺方向輪郭部
18:長辺方向側壁
19:短辺方向側壁
20:長辺方向側壁の上端
21:短辺方向側壁の上端
22:長辺方向傾斜上面部
23:短辺方向傾斜上面部
24:境界/谷折部
25:くぼみ
26:周辺壁部
27:底部
28:易変形部
29:中央領域
30:端部領域
31:指当部
32:上部材
33:下部材
34:支持部
35:ボス
36:端部領域(傾斜面)
37:中央領域
38:突起部
39:貫通孔
40:マイクロニードルパッチ
41:パッチ収容空間
42:パッチ支持面
43:シート基材
44:マイクロニードルアレイ
45:基材フィルム
46:粘着剤層
47:剥離処理層(離型層)
48:基層
49:針
50:両面テープ
55:保護シート
56:変形防止部材
1000:アプリケータ
1001:ハウジング
1011:長辺方向縁部
1012:切り欠き
1013:短辺方向縁部
1014:切り欠き
1015:押圧機構
1016:上部構造
1017:下部構造
1018:弾性伸張部
1019:端部
1020:開口
1021:溝
1022:トーションばね
1023:巻回部分
1024:アーム部分
1025:ピン
1026:溝
1027:指当部
1028:上部
1029:脚部
1030:係合部
1031:連結部材
1032:窪み
1033:上部材
1034:下部材
1035:台部
1036:爪部
1037:突起
1038:円柱ボス
1039:下端部
1040:縦溝
1041:中央板部
1042:傾斜板部
1043:貫通孔
1045:隆起部(突条)
1047:係合溝
1048:切り込み
1051:連結構造
1052:係合爪
1200:アプリケータ
1201:ハウジング
1211:長辺方向縁部
1212:切り欠き
1215:押圧機構
1216:上部構造
1217:下部構造
1218:弾性伸張部
1219:端部
1220:開口
1221:溝
1222:トーションばね
1223:巻回部分
1224:アーム部分
1225:ピン
1226:溝
1227:指当部
1228:上部
1229:脚部
1230:係合部
1251:連結部材
1252:円筒壁
1253:天井壁
1254:窪み
1255:開口
1256:変形部材
1257:係合孔
1261:昇降部材
1262:円筒壁
1263:底壁
1264:係合部
1265:柱
1266:コイルスプリング
1271:板
1272:突起
1273:係合部
Claims (20)
- 上面と下面を有する一枚のシート又はフィルムで構成されており,平坦な周辺基部と,前記周辺基部に囲まれて前記周辺基部に対して前記下面から前記上面に向かう垂直上方に膨出した隆起部を有するハウジングを備えており,
前記隆起部の下面部分がマイクロニードルパッチを支持する面を構成しており,
前記隆起部は複数の谷折部を備えており,
前記谷折部は前記隆起部の中心部から離れる方向に向けた谷底を有する
ことを特徴とするマイクロニードルパッチアプリケータ用ハウジング。 - 前記谷折部は,前記隆起部の中心を通る垂直軸(z軸)に直交し且つ互いに直交する2つの水平軸(x軸,y軸)に対して対称に配置されていることを特徴とする請求項1のマイクロニードルパッチアプリケータ用ハウジング。
- 前記谷折部は,前記垂直軸(z軸)を関して回転対称(n回対称:nは2以上の整数)に配置されていることを特徴とする請求項1のマイクロニードルパッチアプリケータ用ハウジング。
- 前記隆起部は,前記2つの水平軸(x軸,y軸)のうちの少なくとも一方の水平軸に対して対称な形状であることを特徴とする請求項1又は2のマイクロニードルパッチアプリケータ用ハウジング。
- 前記隆起部は,前記2つの水平軸(x軸,y軸)に対して対称な形状であることを特徴とする請求項1又は2のマイクロニードルパッチアプリケータ用ハウジング。
- 前記隆起部は,前記2つの水平軸(x軸,y軸)の一方の水平軸を長軸(x軸)とし且つ前記2つの水平軸の他方の水平軸を短軸(y軸)とする形状であることを特徴とする請求項1又は2のマイクロニードルパッチアプリケータ用ハウジング。
- 前記隆起部は,隆起部の中心を通る垂直軸(z軸)を関して回転対称(n回対称:nは2以上の整数)であることを特徴とする請求項1又は2のマイクロニードルパッチアプリケータ用ハウジング。
- 前記隆起部は中央にくぼみを有し,
前記くぼみの下面部分がマイクロニードルパッチを支持する面を構成していることを特徴とする請求項1~7のいずれかのマイクロニードルパッチアプリケータ用ハウジング。 - 前記隆起部の輪郭に沿って延びるとともに前記くぼみを囲む尾根部を備えており,
前記尾根部が前記複数の谷折部を備えていることを特徴とする請求項1~8のいずれかに記載のマイクロニードルパッチアプリケータ用ハウジング。 - 前記輪郭は,前記2つの水平軸(x軸,y軸)に対して対称な形状であることを特徴とする請求項9のマイクロニードルパッチアプリケータ用ハウジング。
- 前記輪郭は,前記2つの水平軸(x軸,y軸)の一方の水平軸を長軸(x軸)とし且つ前記2つの水平軸の他方の水平軸を短軸(y軸)とする形状であることを特徴とする請求項9のマイクロニードルパッチアプリケータ用ハウジング。
- 前記輪郭は,前記垂直軸(z軸)を関して回転対称(n回対称:nは2以上の整数)であることを特徴とする請求項9のマイクロニードルパッチアプリケータ用ハウジング。
- 前記くぼみは平坦面によって構成されており,
前記平坦面は前記短軸に対して対称に配置され且つ前記短軸(y軸)に平行に伸びる二つの易変形部を有し,前記平坦面が前記二つの易変形部に挟まれた中央領域と,前記中央領域の両側に位置する端部領域に区画されていることを特徴とする請求項8~12のいずれかのマイクロニードルパッチアプリケータ用ハウジング。 - 前記隆起部は,前記垂直軸(z軸)を中心とする周方向に連続に配置されていることを特徴とする請求項2~13のいずれかのマイクロニードルパッチアプリケータ用ハウジング。
- 前記隆起部は,前記垂直軸を中心とする周方向に不連続に配置されていることを特徴とする請求項2~13のいずれかのマイクロニードルパッチアプリケータ用ハウジング。
- 前記複数の谷折部の少なくとも一部は前記隆起部の中心部から離れる方向に向けて下方に傾斜した谷底を有する,ことを特徴とする請求項1~15のいずれかのマイクロニードルパッチアプリケータ用ハウジング。
- 請求項1~16のいずれかのマイクロニードルパッチアプリケータ用ハウジングと,
前記マイクロニードルパッチを支持する面に支持されたマイクロニードルパッチとを備えた,マイクロニードルパッチアプリケータ。 - 前記くぼみに指当部が設けてあることを特徴とする請求項17のマイクロニードルパッチアプリケータ。
- 前記ハウジングの下面に保護シートが貼り付けられており,
前記保護シートが,前記隆起部の背後に形成されたパッド収容空間の開口を塞いでいる,ことを特徴とする請求項17又は18のマイクロニードルパッチアプリケータ。 - 前記指当部は,前記指当部に所定の力が加えられたことを示すインジケータが設けられていることを特徴とする請求項17~19のいずれかのマイクロニードルパッチアプリケータ。
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
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CN201680074673.9A CN108367143B (zh) | 2015-12-21 | 2016-12-20 | 微针贴片施用器及其壳体 |
BR112018012526-1A BR112018012526B1 (pt) | 2015-12-21 | 2016-12-20 | Alojamento de aplicador de adesivo de microagulha, e, aplicador de adesivo de microagulha |
CN202010965959.4A CN112089961B (zh) | 2015-12-21 | 2016-12-20 | 微针贴片施用器及其壳体 |
EP20180240.2A EP3738642A1 (en) | 2015-12-21 | 2016-12-20 | Microneedle patch applicator |
EP16878704.2A EP3395397B1 (en) | 2015-12-21 | 2016-12-20 | Microneedle patch applicator housing |
JP2017558162A JP6840389B2 (ja) | 2015-12-21 | 2016-12-20 | マイクロニードルパッチアプリケータ及びそのハウジング |
ES16878704T ES2928981T3 (es) | 2015-12-21 | 2016-12-20 | Alojamiento para aplicador de parches de microagujas |
US16/062,671 US11167119B2 (en) | 2015-12-21 | 2016-12-20 | Microneedle patch applicator and housing for same |
US17/479,070 US11701507B2 (en) | 2015-12-21 | 2021-09-20 | Microneedle patch applicator and housing for same |
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PCT/JP2015/085707 WO2016129184A1 (ja) | 2015-02-13 | 2015-12-21 | マイクロニードルの穿刺装置及びマイクロニードルパッチの貼付装置 |
JPPCT/JP2015/085707 | 2015-12-21 | ||
JP2016158930 | 2016-08-12 | ||
JP2016-158930 | 2016-08-12 |
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US16/062,671 A-371-Of-International US11167119B2 (en) | 2015-12-21 | 2016-12-20 | Microneedle patch applicator and housing for same |
US17/479,070 Continuation US11701507B2 (en) | 2015-12-21 | 2021-09-20 | Microneedle patch applicator and housing for same |
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EP (2) | EP3738642A1 (ja) |
JP (2) | JP6840389B2 (ja) |
CN (2) | CN112089961B (ja) |
BR (1) | BR112018012526B1 (ja) |
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Cited By (4)
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WO2019176900A1 (ja) * | 2018-03-13 | 2019-09-19 | 株式会社メドレックス | 粘着部材、及びマイクロニードル貼付剤 |
JP2020174855A (ja) * | 2019-04-17 | 2020-10-29 | 富士フイルム株式会社 | 収容容器、マイクロニードルユニット、収容容器群、及びマイクロニードルユニットの製造方法 |
CN112969495A (zh) * | 2018-10-31 | 2021-06-15 | 富士胶片株式会社 | 微针阵列单元 |
WO2023145877A1 (ja) * | 2022-01-28 | 2023-08-03 | 株式会社 メドレックス | アプリケータ、およびマイクロニードルパッチキット |
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WO2017110815A1 (ja) | 2015-12-21 | 2017-06-29 | 株式会社 メドレックス | マイクロニードルパッチアプリケータ及びそのハウジング |
JP1632957S (ja) * | 2018-10-30 | 2019-06-03 | ||
KR102279603B1 (ko) * | 2019-06-11 | 2021-07-20 | (주)비올 | 바늘 조립체, 이를 포함하는 피부 자극기 및 그 제조 방법 |
JP6734501B1 (ja) * | 2020-03-09 | 2020-08-05 | 三島光産株式会社 | マイクロニードル用アプリケータ |
KR102613830B1 (ko) * | 2021-06-17 | 2023-12-14 | 주식회사 에스엔비아 | 마이크로구조체 카트리지 및 마이크로구조체 어플리케이터 |
WO2023163787A1 (en) * | 2022-02-23 | 2023-08-31 | Deka Products Limited Partnership | Delivery device apparatuses, systems, and methods |
CN116270422B (zh) * | 2023-05-19 | 2023-09-05 | 优微(珠海)生物科技有限公司 | 微针贴 |
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2016
- 2016-12-20 WO PCT/JP2016/087965 patent/WO2017110815A1/ja active Application Filing
- 2016-12-20 EP EP20180240.2A patent/EP3738642A1/en not_active Withdrawn
- 2016-12-20 US US16/062,671 patent/US11167119B2/en active Active
- 2016-12-20 CN CN202010965959.4A patent/CN112089961B/zh active Active
- 2016-12-20 CN CN201680074673.9A patent/CN108367143B/zh active Active
- 2016-12-20 BR BR112018012526-1A patent/BR112018012526B1/pt active IP Right Grant
- 2016-12-20 JP JP2017558162A patent/JP6840389B2/ja active Active
- 2016-12-20 ES ES16878704T patent/ES2928981T3/es active Active
- 2016-12-20 EP EP16878704.2A patent/EP3395397B1/en active Active
-
2019
- 2019-01-29 JP JP2019013418A patent/JP6807609B2/ja active Active
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2021
- 2021-09-20 US US17/479,070 patent/US11701507B2/en active Active
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2019176900A1 (ja) * | 2018-03-13 | 2019-09-19 | 株式会社メドレックス | 粘着部材、及びマイクロニードル貼付剤 |
JPWO2019176900A1 (ja) * | 2018-03-13 | 2021-03-11 | 株式会社 メドレックス | 粘着部材、及びマイクロニードル貼付剤 |
CN112969495A (zh) * | 2018-10-31 | 2021-06-15 | 富士胶片株式会社 | 微针阵列单元 |
CN112969495B (zh) * | 2018-10-31 | 2022-11-08 | 富士胶片株式会社 | 微针阵列单元 |
JP2020174855A (ja) * | 2019-04-17 | 2020-10-29 | 富士フイルム株式会社 | 収容容器、マイクロニードルユニット、収容容器群、及びマイクロニードルユニットの製造方法 |
JP7074714B2 (ja) | 2019-04-17 | 2022-05-24 | 富士フイルム株式会社 | 収容容器、マイクロニードルユニット、収容容器群、及びマイクロニードルユニットの製造方法 |
WO2023145877A1 (ja) * | 2022-01-28 | 2023-08-03 | 株式会社 メドレックス | アプリケータ、およびマイクロニードルパッチキット |
Also Published As
Publication number | Publication date |
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BR112018012526B1 (pt) | 2022-08-09 |
EP3738642A1 (en) | 2020-11-18 |
EP3395397B1 (en) | 2022-10-12 |
CN108367143B (zh) | 2021-02-12 |
JP2019058829A (ja) | 2019-04-18 |
US20220001160A1 (en) | 2022-01-06 |
JPWO2017110815A1 (ja) | 2018-10-18 |
CN112089961B (zh) | 2022-08-09 |
US20180361132A1 (en) | 2018-12-20 |
EP3395397A4 (en) | 2019-07-03 |
CN112089961A (zh) | 2020-12-18 |
JP6807609B2 (ja) | 2021-01-06 |
US11167119B2 (en) | 2021-11-09 |
CN108367143A (zh) | 2018-08-03 |
BR112018012526A2 (ja) | 2018-12-11 |
JP6840389B2 (ja) | 2021-03-10 |
ES2928981T3 (es) | 2022-11-23 |
EP3395397A1 (en) | 2018-10-31 |
US11701507B2 (en) | 2023-07-18 |
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