WO2017082629A2 - 점막염의 치료 방법 - Google Patents
점막염의 치료 방법 Download PDFInfo
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- WO2017082629A2 WO2017082629A2 PCT/KR2016/012870 KR2016012870W WO2017082629A2 WO 2017082629 A2 WO2017082629 A2 WO 2017082629A2 KR 2016012870 W KR2016012870 W KR 2016012870W WO 2017082629 A2 WO2017082629 A2 WO 2017082629A2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/067—Radiation therapy using light using laser light
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/0606—Mouth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0601—Apparatus for use inside the body
- A61N5/0603—Apparatus for use inside the body for treatment of body cavities
- A61N2005/0609—Stomach and/or esophagus
Definitions
- the present invention provides a method for preventing or treating mucositis, such as oral mucositis (eg, oral ulcers) and gastrointestinal mucositis, and compositions useful therein, more particularly pharmaceutical compositions and health functions, comprising administration of a monoacetyldiacylglycerol compound. It relates to a food composition.
- mucositis such as oral mucositis (eg, oral ulcers) and gastrointestinal mucositis
- compositions useful therein more particularly pharmaceutical compositions and health functions, comprising administration of a monoacetyldiacylglycerol compound. It relates to a food composition.
- Mucositis is a pathological condition characterized by damage to the mucosa, ranging from mild inflammation to ulcers deep and affecting one or more areas of the digestive tract from the mouth to the anus. Mucositis generally occurs as a side effect of treating diseases such as cancer. As a result of cell death due to reaction to chemotherapy, inflammation and ulceration may occur in the mucosal lining of the digestive tract as thin as the mouth. Radiation therapy of the head and neck or pelvis or abdomen can also cause oral or gastrointestinal mucositis. Oral and gastrointestinal (GI) mucositis occurs in many patients who receive high doses of chemotherapy and hematopoietic stem cell transplantation (HSCT). Oral mucositis persisted particularly severe and long-term among HSCT patients who received systemic irradiation.
- GI Oral and gastrointestinal
- Treatment-induced mucositis is one of the extreme debilitating and chronic side effects of cancer treatment and affects the quality of life of patients.
- Oral mucositis is usually described as including erythema and / or ulcers of the mucous membranes.
- TPN total parenteral nutrition
- Gastrointestinal mucositis usually appears with pain, bloating, diarrhea, nausea and vomiting.
- mucositis is associated with significant morbidity, poor quality of life, as well as negative health and economic consequences.
- mucositis can interfere with routine administration and dosage of a programmed treatment plan, affecting the outcome of cancer treatment.
- Oral ulcers are a very common manifestation of oral mucositis and are associated with many diseases and are caused by many different mechanisms.
- Recurrent oral ulcers are conditions in which a tear or sore of the mucosa occurs periodically in the oral cavity. The underlying cause of recurrent oral ulcers remains unclear.
- family orientation, trauma, hormonal factors, food or drug hypersensitivity, emotional stress, chemotherapy, radiation therapy, neutrophil reduction and autoimmune diseases are known to make recurrent oral ulcers susceptible.
- RAS recurrent aphthous stomatitis
- SLE systemic lupus erythematosus
- BD Behcet's disease
- Recurrent aphthous stomatitis is the most common cause of oral ulcers.
- Afta is a painful oral lesion with a grayish basal round and shallow ulcer locally.
- the etiology of aphthous ulcers is not clear.
- the cause of the aphthous ulcer is not entirely clear, it is speculated that it is caused by bacterial infection, viral infection or immunomodulatory disorder. It is also known that hot food, oral wounds, fatigue or allergies can cause or worsen aphthous stomatitis.
- SLE Systemic lupus erythematosus
- SLE is a chronic systemic autoimmune disease that affects many organs in the body, such as the skin, joints, kidneys, lungs, and nervous system.
- the exact cause of SLE is unknown, but several factors, such as genes, hormones and environmental factors, have been associated with SLE.
- Common symptoms of SLE include rashes in the cheeks and ulcers in the nose and mouth. SLE can also cause joint pain, kidney problems and depression.
- Behcet's disease is a rare immune mediated small vessel systemic vasculitis that often appears with oral ulcers, genital ulcers and ocular problems. As a systemic disease, it can also affect several organs such as the gastrointestinal tract, lungs, musculoskeletal system, cardiovascular and nervous system. The most common symptoms include oral ulcers, genital ulcers, inflammation of the eyes, skin lesions and arthritis. The exact cause of SLE is unknown, but some factors, such as genetic and environmental factors, may be the cause of Behcet's disease.
- Deer Antler is an Unhorned Deer ( Cornu cervi ) is a dried oriental horn, traditionally widely used oriental medicine.
- Deer Antler has various medical effects, such as growth and development promoting effects, promoting hematopoietic function, and treating nervous breakdown, as described in the Korean Medical Book Agreement published for the first time in 1613. It has been well received for improving the function.
- antler is known to have a variety of medical effects, such as stretching strength and endurance, improving myocardial exercise, restoring fatigue, and boosting the immune system. The active ingredients of antler and their efficacy are being studied.
- Deer antler including, for example, rac-1-palmitoyl-2-linoleoyl-3-acetylglycerol (PLAG) obtained from chloroform extract of antler. Certain components of have been reported to have growth promoting activity of hematopoietic stem cells and megakaryocytes (WO 99/26640). In addition, monoacetyldiacylglycerol derivatives, an oily component of antler, have been reported to be effective in the treatment of cancers such as autoimmune diseases, sepsis, biliary tract cancer, kidney cancer or malignant melanoma (WO 2005/112912).
- cancers such as autoimmune diseases, sepsis, biliary tract cancer, kidney cancer or malignant melanoma
- the present invention provides a pharmaceutical composition for preventing or treating mucositis and a method for preventing or treating mucositis using the same.
- the present invention provides a pharmaceutical composition for preventing, ameliorating or treating mucositis, such as oral mucositis (eg, oral ulcers) and gastrointestinal mucositis, comprising monoacetyldiacylglycerol of Formula 1, particularly PLAG, as an active ingredient.
- mucositis such as oral mucositis (eg, oral ulcers) and gastrointestinal mucositis, comprising monoacetyldiacylglycerol of Formula 1, particularly PLAG, as an active ingredient.
- mucositis such as oral mucositis (eg, oral ulcers) and gastrointestinal mucositis
- monoacetyldiacylglycerol of Formula 1, particularly PLAG as an active ingredient.
- R 1 and R 2 are each independently a fatty acid group having 14 to 20 carbon atoms.
- the present invention provides a method for preventing or treating mucositis, such as oral mucositis (eg, oral ulcers) and gastrointestinal mucositis, comprising administering to a patient in need thereof an effective amount of a compound of Formula 1, particularly PLAG.
- mucositis such as oral mucositis (eg, oral ulcers) and gastrointestinal mucositis
- administering comprising administering to a patient in need thereof an effective amount of a compound of Formula 1, particularly PLAG.
- Compounds of the invention for preventing or treating mucositis include glycerol derivatives having one acetyl group and two acyl groups of Formula 1:
- R 1 and R 2 are each independently a fatty acid group having 14 to 20 carbon atoms.
- the glycerol derivative of formula 1 is sometimes named monoacetyldiacylglycerol (MDAG).
- Fatty acid groups refer to acyl moieties resulting from the formation of ester bonds by reaction of fatty acids and alcohols.
- R1 and R2 include palmitoyl, oleoyl, linoleoyl, linolenoyl, stearoyl, stearoyl, myristoyl, arachido Arachidonoyl and the like.
- R1 and R2 are oleooil / palmitoyl, palmitoyl / oleoyl, palmitoyl / linoleyl oil, palmitoyl / linoleyl oil, palmitoyl / arachidonoyl, palmitoyl / stearo Sun, palmitoyl / palmitoyl, oleoyl / stearoyl, linoleyl / palmitoyl, linoleyl / stearoyl, stearoline / linoleyl, stearoyl / oleoyl, myristoyl / linol Leoyl, myristoil / oleoil, and the like.
- the monoacetyldiacylglycerol derivatives of Formula 1 may be (R) -type, (S) -type or racemic mixtures, and may also include stereoisomers thereof.
- the R1 and / or R2 substituent is an unsaturated fatty acid group, the double bond may be in cis form.
- monoacetyldiacylglycerol is a compound represented by Formula 2:
- the compound of formula 2 is 1-palmitoyl-2-linoleoyl-3-acetylglycerol and may sometimes be named "PLAG" in the present invention.
- R 1 and R 2 of the compound of formula 2 are palmitoyl and linoleoyl, respectively.
- 2-carbon in the glycerol moiety is chiral.
- PLAG is generally provided as a racemic compound and the R- and S-enantiomers appear to have the same activity.
- PLAG of Formula 2 is known to increase the survival rate of animals in sepsis animal motel experiments with cecal-ligation-puncture and is not toxic in Good Laboratory Practice (GLP) toxicity tests. done.
- GLP Good Laboratory Practice
- the effect of the monoacetyldiacylglycerol compound comprising PLAG in mucositis is unknown or unknown in previous studies.
- Monoacetyldiacylglycerol compounds can be isolated and extracted from natural antler or can be prepared by known organic synthesis methods. More specifically, the antler is extracted with hexane, and then the residue is extracted with chloroform and the chloroform is removed to provide a chloroform extract. The volume of solvent for this extraction is sufficient to cover the antler. Generally, approximately 4-5 liters of hexane and / or chloroform are used per kg of antler, but are not limited thereto. The extract obtained by this method is then fractionated and purified using a series of silica gel column chromatography and TLC methods to obtain the monoacetyldiacylglycerol compound of the present invention.
- the solvent for the extract is selected from, but is not limited to, chloroform / methanol, hexane / ethylacetate / acetic acid.
- Chemical synthesis methods for the preparation of monoacetyldiacylglycerol compounds are shown, for example, in Korean Patent Nos. 10-0789323 and 10-1278874, the contents of which are incorporated herein by reference.
- the monoacetyldiacylglycerol compounds of the present invention are effective in the prevention or treatment of mucositis, such as oral mucositis (eg, oral ulcers) and gastrointestinal mucositis.
- mucositis such as oral mucositis (eg, oral ulcers) and gastrointestinal mucositis.
- oral mucositis eg, oral ulcers
- gastrointestinal mucositis e.g, oral ulcers
- In vivo studies show that patients with PLAG significantly improve the symptoms of oral ulcers.
- the present invention provides a method for preventing or treating mucositis comprising administering to a patient in need thereof an effective amount of a compound of formula 1, in particular PLAG.
- mucositis can be any kind of mucositis, including oral mucositis (eg, oral ulcers) or gastrointestinal mucositis. Mucositis can be caused by several causes. For example, mucositis can occur as a side effect of cancer treatment, including chemotherapy and / or radiotherapy. Several types of mucosal damage, such as those associated with herpes simplex virus (HSV) and candida infections, can also occur as mucositis.
- HSV herpes simplex virus
- candida infections can also occur as mucositis.
- HSCT hematopoietic stem cell transplantation
- Mucositis may be recurrent oral ulceration.
- Recurrent oral ulcers can occur as a result of a number of conditions or diseases such as chemotherapy, radiation therapy, a reduced state of neutrophils and autoimmune diseases.
- recurrent aphthous stomatitis (RAS) recurrent aphthous stomatitis
- SLE systemic lupus erythematosus
- BD Behcet's disease
- Monoacetyldiacyl glycerol compounds in particular PLAG, are effective in the prevention or treatment of double oral ulcers caused by this disorder.
- the monoacetyldiacylglycerol compound is administered alone or in combination with additional additives or therapies that treat or alleviate mucositis sequentially or simultaneously.
- additional additives or therapies include paripamine (recombinant human keratinocyte growth factor), amifostine, gelclair, zilactin, IL-6 antagonists such as anti-IL-6 antibodies and low power lasers.
- LLLT Treatment
- the pharmaceutical composition of the invention for the prevention or treatment of mucositis consists of monoacetyldiacylglycerol of formula 1 alone, or in a substantial amount of pure, in particular PLAG, or as an active ingredient (monoacetyldiacylglycerol of formula 1, in particular PLAG ) And typically pharmaceutically acceptable carriers, excipients or diluents.
- the amount of monoacetyldiacylglycerol in the pharmaceutical composition may be wide without particular limitation, and specifically, 0.0001 to 100% by weight, such as 0.001 to 50% by weight, 0.01 to 20% by weight, 50 to 50, based on the total amount of the composition. 95 weight percent or 95-99 weight percent.
- compositions may be formed in the form of solids, liquids, gels or suspensions for oral or parenteral administration, and include, for example, capsules, emulsions, suspensions, such as tablets, pills, powders, granules, hard or soft gelatin capsules, Syrups, emulsions, sterile aqueous solutions, non-aqueous solvents, lyophilizers, suppositories, and the like.
- conventional excipients or diluents such as fillers, extenders, binders, wetting agents, disintegrating agents, surfactants can be used.
- Solid preparations for oral administration include tablets, pills, powders, granules, capsules, and the like, and solid preparations include one or more active ingredients and at least one such as starch, calcium carbonate, sucrose, lactose, gelatin, and the like. It can be prepared by mixing excipients. In addition to excipients, lubricants such as magnesium stearate, talc can be used.
- Liquid preparations for oral administration include emulsions, suspensions, syrups, and the like, and may include conventional diluents such as water, liquid paramins, or various excipients such as wetting agents, sweeteners, fragrances, and preservatives.
- Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solvents, lyophilizers and suppositories, and the like, and solvents for such solutions may include propylene glycol, vegetable oils such as olive oil, injectable esters such as ethyl oleate Can be.
- Base materials for suppositories may include witepsol, macrogol, tween 61, cacao butter, laurin and glycerol gelatin.
- the monoacetyldiacylglycerol compound may be administered in a pharmaceutically effective amount.
- pharmaceutically effective amount is used to refer to an amount for achieving a sufficiently favorable result for medical treatment.
- pharmaceutically effective amount may be determined according to the type of subject, age, sex, severity and type of disease, drug activity, sensitivity to the drug, time of administration, route of administration, rate of excretion, and the like.
- preventing or “preventing” includes any action in which the occurrence of mucositis is inhibited or delayed by administering a composition of the present invention.
- Said “treatment” or “treating” includes the prevention, alleviation, amelioration, delay or reduction of mucositis symptoms, as well as the partial or complete elimination or prevention of mucositis symptoms by administering a composition of the invention.
- the composition of the present invention may be administered sequentially or simultaneously, either alone or like other drugs.
- Preferred amounts of the composition of the present invention may vary depending on the condition and weight of the patient, the severity of the disease, the form of the drug preparation, the route of administration and the duration of treatment. Suitable amounts for daily administration can be determined by the physician and are generally about 0.05 to 200 mg / kg.
- a suitable total dosage per day was determined to be 0.1 to 100 mg / kg based on adult males.
- a total amount of 50 mg / kg may be administered once a day or divided into two, three or four times a day.
- the present invention is divided into 500 mg in the morning and 500 mg in the evening so that the daily dosage is 500 mg to 4,000 mg, for example 1000 mg / day once or twice a day.
- a pharmaceutically acceptable tocopherol compound such as an antioxidant
- a-tocophenol other triglycerides
- a pharmaceutical composition for preventing or treating mucositis comprising 250 to 1000 mg, such as 250 mg or 500 mg of PLAG.
- composition of the present invention can be administered to any patient in need of prevention or treatment of mucositis.
- the compositions of the present invention can be administered to humans as well as non-human animals (especially mammals), such as monkeys, dogs, cats, rabbits, guinea pigs, rats, mice, cattle, sheep, pigs, goats and the like.
- the compositions of the present invention may be administered in a variety of known methods, for example, by oral or rectal administration or by intravenous (iv), intramuscular (im), subcutaneous (sc) or cerebrovascular injection. It can be administered by.
- the present invention provides a nutraceutical composition for preventing, treating or ameliorating mucositis, comprising an effective amount of monoacetyldiacylglycerol of Formula 1, in particular PLAG:
- R 1 and R 2 are each independently a fatty acid group having 14 to 20 carbon atoms.
- the term "improvement” or “improvement” includes any activity in which the symptoms of mucositis are ameliorated by administering a composition of the invention.
- the nutraceutical composition of the present invention for preventing or ameliorating mucositis consists solely or in a substantial amount of pure monoacetyldiacylglycerol of formula 1, in particular PLAG, or the active ingredient (monoacetyldiacylglycerol of formula 1, In particular PLAG) and other known ingredients of dietary supplements.
- the amount of monoacetyldiacylglycerol in the nutraceutical composition can vary widely and is generally less than 15% by weight, preferably less than 10% by weight relative to the total amount of the nutraceutical composition. However, the amount of monoacetyldiacylglycerol can be increased or decreased.
- Foods to which the compound of the present invention may be added include various foods, for example, meat, sausage, bread, chocolate, candy, confectionary, pizza, noodles, gums and ice cream, soups, beverages, teas, drinks, alcoholic beverages, Dairy products such as vitamin complexes and animal feed.
- the beverage products may comprise sweetening agents, flavors or carbohydrates.
- carbohydrates include monosaccharides such as glucose and fructose, disaccharides such as maltose and sugar, polysaccharides such as dextrin and cyclodextrin and sugar alcohols such as xylitol, sorbitol and erythritol.
- the amount of carbohydrate in the beverage composition can be wide without particular limitation, and preferably from 0.001 to 0.04 g, more preferably from 0.02 to 0.03 g per 100 ml of beverage.
- sweeteners include natural sweeteners such as taumartin and stevia extract and artificial sweeteners such as saccharin and aspartame.
- the nutraceutical composition of the present invention is a nutritional supplement, vitamins, electrolytes, flavors, coloring agents, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloidal thickeners, pH regulators, stabilizers, preservatives, glycerin, Alcohols, carbonating agents used in carbonated drinks, and the like.
- the nutraceutical compositions of the present invention may comprise natural fruit juices and fruits used for the production of fruit juice beverages and vegetable beverages.
- the invention provides a method of preventing or treating mucositis (Method 1) comprising administering to a patient in need thereof an effective amount of a compound of Formula 1:
- R 1 and R 2 are each independently a fatty acid group having 14 to 20 carbon atoms, such as PLAG;
- R 1 and R 2 are each independently selected from the group comprising palmitoyl, oleoyl, linoleoyl, linolenic oil, stearoyl, myristoyl and arachidonoyl.
- R 1 and R 2 are oleoil / palmitoyl, palmitoyl / oleoil, palmitoyl / linoleyl oil, palmitoyl / linolenic oil, palmitoyl / arachidonoyl, palmitoyl / stearo Sun, palmitoyl / palmitoyl, oleoyl / stearoyl, linoleyl / palmitoyl, linoleyl / stearoyl, stearoyl / linoleyl, stearoyl / oleoyl, myristoyl / linol Method 1 or 1.1, selected from the group comprising leoyl, myristoyl / oleoyl.
- the compound of formula 2 is administered in a pharmaceutical composition that is substantially free of other monoacetyldiacylglycerols, such as at least 95%, eg, at least 99%, of the total monoacetyldiacylglycerol in the formulation of Formula 2 Preceding method.
- the compound of formula (2) is administered in a pharmaceutical composition that is substantially free of other monoacetyldiacylglycerol compounds.
- the compound of formula (2) is administered in a pharmaceutical composition that is substantially free of other tridsleyide.
- the compound of formula 1 is prepared by chemical synthesis.
- Mucositis is an oral mucositis (eg oral ulcer) or gastrointestinal mucositis, the preceding method.
- Mucositis is a recurrent oral ulcer.
- a recurrent oral ulcer is caused by a disease or condition selected from chemotherapy, radiation therapy, a reduced state of neutrophils and autoimmune diseases.
- the recurrent oral ulcer is caused by a disease selected from recurrent aphthous stomatitis (RAS), systemic lupus erythematosus (SLE) and Bech's disease (BD).
- RAS recurrent aphthous stomatitis
- SLE systemic lupus erythematosus
- BD Bech's disease
- Mucositis is a preceding method that results from infections such as herpes simplex virus (HSV) and Candida infection.
- HSV herpes simplex virus
- Candida infection results from infections such as herpes simplex virus (HSV) and Candida infection.
- the mucositis is caused by cancer treatment, including chemotherapy and / or radiation therapy.
- the mucositis is caused by radiation treatment, in whole or in part, the preceding method.
- Mucositis is caused by chemotherapy, in whole or in part.
- Mucositis includes Ziv-aflibercept, Brentuximab Vedotin, Deferiprone, Gemcitabine, Pralatrexate, Gancyclovir ( Ganciclovir, Valganciclovir, Thalidomide, Romidepsin, Boceprevir, Decitabine, Imatinib, Topotecan, Lenalidomide Lenalidomide, Paclitaxel, Ollanzapine, Irinotecan, Paliperidone, Interferons, Lipopolysaccharide, Tamoxifen, Flaminide (Flecainide) Cardiac antiarrhythmics), Phenytoin, Indomethacin, Propythiouracil, Carbimazole, Chlorpromazine, Trimethoprim / sulfamethoxazole (Trimethoprim / sulfamethoxazole) Cotrymoxazole (c otrimoxazole), Clozapine, Ti
- the patient is instructed to undergo chemotherapy or radiation therapy at a dose sufficient to cause mucositis in the absence of other treatments, or suffer from mucositis resulting from chemotherapy or radiation therapy.
- Mucositis is related to hematopoietic stem cell transplantation or peripheral stem cell injection.
- Excipients include Palifermin (recombinant human keratinocyte growth factor, keratinocyte growth factor, Amifostine, Gelcair, antagonists (eg anti-IL-6 antibody) and The preceding method, which is selected from the group comprising mixtures thereof.
- a compound of Formula 1, such as PLAG is administered in the form of a pharmaceutical composition for oral administration.
- the compound of formula 1, such as PLAG is a compound of formula 1 in combination or in conjunction with a pharmaceutically acceptable diluent or carrier, e.g., a diluent or carrier comprising an edible oil such as vegetable oil, e.g. olives.
- a pharmaceutically acceptable diluent or carrier e.g., a diluent or carrier comprising an edible oil such as vegetable oil, e.g. olives.
- Prior art methods, such as PLAG is administered in the form of a pharmaceutical composition that is a soft gelatin capsule.
- a compound of Formula 1, such as PLAG is administered in the form of a pharmaceutical composition comprising 0.0001 to 100% by weight, for example 50 to 95% or 95 to 99% by weight of the composition.
- the composition is propyl gallate (PG, E310), tertiary butylhydroquinone (TBHQ), butylated hydroxyanisole (BHA, E320) and butylated hydroxytoluene (butylated hydroxytoluene, BHT) , E321), for example, synthetic antioxidants such as a-tocopherol, as well as pharmaceutically acceptable antioxidants such as ascorbic acid (AA, E300) and tocopherols, E306).
- PG propyl gallate
- TBHQ tertiary butylhydroquinone
- BHA butylated hydroxyanisole
- BHT butylated hydroxytoluene
- E321 for example, synthetic antioxidants such as a-tocopherol, as well as pharmaceutically acceptable antioxidants such as ascorbic acid (AA, E300) and tocopherols, E306).
- Compounds of formula (1) such as PLAG
- PLAG may be used in combination with or in conjunction with almost 50 mg of pharmaceutically acceptable diluents or carriers such as edible oils such as vegetable oils, such as olive oil.
- pharmaceutically acceptable diluents or carriers such as edible oils such as vegetable oils, such as olive oil.
- the preceding method wherein the PLAG is a compound of Formula 2 administered in the form of a soft gelatin capsule comprising 250 mg or 500 mg.
- a compound of formula 1, such as PLAG is administered in the form of a dietary supplement that is added or mixed into a suitable food for human consumption.
- the total daily dose of the compound of formula 1, such as PLAG is 250 mg to 2000 mg / day, for example 500 mg to 1500 mg / day, such as 500 mg / day, 1000 mg / day or 1500 mg / day , Preceding method.
- a compound of Formula 1, such as PLAG is administered in a dosage of 250 mg or 500 mg twice daily, such as morning and evening.
- the pharmaceutical composition is a preparation of a solid, liquid, gel or suspension for oral or parenteral administration.
- Compounds of Formula 1, such as PLAG are substantially free of other triglycerides, and oral administration comprises from 250 to 1000 mg of a compound of Formula 1, such as PLAG, together with 0.1 to 3 mg of a pharmaceutically acceptable tocopherol compound. Prior to administration in the form of soft gelatin capsules.
- Compounds of Formula 1, such as PLAG are substantially free of other triglycerides and are soft for oral administration comprising 250 to 1000 mg of compounds of Formula 1, such as PLAG, together with 1 mg of a pharmaceutically acceptable tocopherol compound.
- the preceding method which is administered in the form of a gelatin capsule and is administered once or twice a day.
- the compound of formula 1 is a compound of formula 2 (PLAG) administered in the form of soft gelatin capsules for transdermal administration comprising 250 mg or 500 mg of PLAG drug substance and 1 mg of a-tocopherol as antioxidant, 250 mg
- the preceding method which is administered once or twice a day at a daily total dose of 4,000 mg.
- the compound of formula 1 is a compound of formula 2 (PLAG) administered in the form of soft gelatin capsules for transdermal administration comprising 500 mg PLAG drug substance and 1 mg a-tocopherol as antioxidant, 500 mg to 4,000 mg The preceding method, wherein the total daily dose of is administered once or twice a day.
- PLAG compound of formula 2
- the preceding method is to prevent the treatment.
- the present invention further provides a compound of formula 1 such as PLAG (or a pharmaceutical composition such as the compound of formula 1 described herein) for use in the prevention or treatment of mucositis, for example for use in any of method 1 and below.
- a pharmaceutical composition comprising an effective amount of PLAG).
- the present invention further provides the use of a compound of formula (1), such as PLAG, in the manufacture of a medicament for the prevention or treatment of mucositis, eg, in any of the following of method 1.
- a compound of formula (1) such as PLAG
- the present invention further provides an effective amount of a compound of formula (1), such as PLAG, for use in any of the following of method 1, for example for any use of method 1, for use in the prevention, treatment or amelioration of mucositis It provides a health functional food composition comprising.
- a compound of formula (1) such as PLAG
- ROUs recurrent oral ulcers
- PLAG and (ii) comprises a- soil collection roll
- an example of soft gelatine capsules for use in the methods described herein are prepared in the following composition:
- ingredient function Unit formula PLAG Active ingredient 250.0 or 500.0 mg Alpha-tocopherol Antioxidant 1.0 mg
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Description
환자 | 나이 | 성별 | 치료기간 | 상태 | 궤양 빈번도 변화 | 궤양 심각도 변화 | 궤양 기간 변화 | 총점 | 상당한 개선의 판별 |
1 | 48 | F | 30d | BD | 3 | 3 | 4 | 10 | 1 |
2 | 62 | F | 30d | 2 | 2 | 2 | 6 | 1 | |
3 | 54 | F | 30d | 3 | 2 | 3 | 8 | 1 | |
4 | 58 | F | 30d | 2 | 2 | 3 | 7 | 1 | |
5 | 53 | F | 30d | RAS | 2 | 2 | 1 | 5 | 1 |
6 | 67 | F | 30d | 2 | 0 | 0 | 2 | 0 | |
7 | 43 | F | 30d | 2 | 2 | 3 | 7 | 1 | |
8 | 22 | M | 30d | 2 | 3 | 1 | 6 | 1 | |
9 | 40 | F | 30d | RAS | 2 | 2 | 3 | 7 | 1 |
10 | 43 | M | 30d | 2 | 3 | 2 | 7 | 1 | |
11 | 50 | F | 30d | 1 | 2 | 1 | 4 | 0 | |
12 | 44 | F | 30d | 1 | 2 | 1 | 4 | 0 | |
13 | 37 | F | 30d | BD | 3 | 3 | 2 | 8 | 1 |
14 | 34 | F | 30d | BD | 3 | 3 | 2 | 8 | 1 |
15 | 58 | F | 30d | SLE | 1 | 2 | 1 | 4 | 0 |
16 | 53 | F | 30d | BD | 1 | 2 | 1 | 4 | 0 |
17 | 57 | F | 30d | RAS | 3 | 3 | 2 | 8 | 1 |
18 | 53 | F | 30d | RAS | 3 | 2 | 2 | 7 | 1 |
19 | 33 | F | 30d | RAS | 3 | 3 | 3 | 9 | 1 |
20 | 30 | F | 30d | RAS | 1 | 2 | 1 | 4 | 0 |
21 | 54 | M | 30d | BD | 2 | 1 | 2 | 5 | 1 |
22 | 49 | F | 14d | RAS | 3 | 3 | 2 | 8 | 1 |
23 | 43 | M | 14d | BD | 1 | 2 | 2 | 5 | 1 |
24 | 44 | F | 30d | BD | 2 | 1 | 0 | 3 | 0 |
25 | 57 | F | 30d | BD | 2 | 2 | 2 | 6 | 1 |
26 | 40 | M | 30d | RAS | 3 | 3 | 4 | 10 | 1 |
27 | 46 | F | 30d | BD | 1 | 2 | 1 | 4 | 0 |
28 | 50 | F | 30d | RAS | 2 | 3 | 2 | 7 | 1 |
29 | 38 | F | 30d | BD | 2 | 3 | 3 | 8 | 1 |
30 | 53 | F | 30d | RAS | 1 | 1 | 1 | 3 | 0 |
31 | 80 | F | 30d | RAS | 2 | 3 | 2 | 7 | 1 |
32 | 71 | F | 30d | RAS | 2 | 1 | 1 | 4 | 0 |
33 | 31 | F | 30d | BD | 3 | 1 | 1 | 5 | 1 |
34 | 56 | F | 30d | RAS | 2 | 1 | 2 | 5 | 1 |
35 | 61 | F | 30d | RAS | 1 | 1 | 2 | 4 | 0 |
36 | 25 | F | 30d | RAS | 3 | 2 | 2 | 7 | 1 |
37 | 64 | F | 14d | RAS | 2 | 1 | 1 | 4 | 0 |
38 | 58 | F | 30d | BD | 3 | 4 | 4 | 11 | 1 |
39 | 49 | F | 30d | BD | 2 | 2 | 2 | 6 | 1 |
40 | 55 | M | 30d | RAS | 3 | 4 | 2 | 9 | 1 |
41 | 52 | M | 30d | BD | 2 | 3 | 2 | 7 | 1 |
42 | 43 | M | 30d | RAS | 1 | 2 | 1 | 4 | 0 |
43 | 54 | M | 30d | RAS | 2 | 1 | 1 | 4 | 0 |
44 | 56 | M | 30d | RAS | 2 | 2 | 2 | 6 | 1 |
평균 | 49.3 | M 10 | 2.07 | 2.14 | 1.86 | 5.93 | 30 | ||
표준편차 | 9.0 | F 34 | 0.55 | 0.68 | 0.72 | 1.76 | 30/44 (68.18%) |
성분 | 기능 | 단위 포뮬러 |
PLAG | 활성 성분 | 250.0 또는 500.0 mg |
알파-토코페롤 | 산화 방지제 | 1.0 mg |
성분 | 기능 |
젤라틴 | 캡슐 쉘 |
농축된 글리세린 | 가소제 |
메틸 파라-옥시벤조에이트 | 방부제 |
프로필 파라-옥시벤조에이트 | 방부제 |
에틸 바닐린 | 향미제 |
이산화 티타늄 | 착색제 |
타르 색소, MFDS notified Blue No. 1 | 착색제 |
타르 색소, MFDS notified Red No. 40 | 착색제 |
,타르 색소 MFDS notified Yellow No. 203 | 착색제 |
정제수 | 전색제 |
Claims (30)
- 청구항 1에 있어서, R1 및 R2는 각각 독립적으로 팔미토일, 올레오일, 리놀레오일, 리놀렌오일, 스테아로일, 미리스토일 및 아라키도노일을 포함하는 군으로부터 선택되는 것인, 방법.
- 청구항 1에 있어서, R1 및 R2(R1/R2)는 올레오일/팔미토일, 팔미토일/올레오일, 팔미토일/리놀레오일, 팔미토일/리놀렌오일, 팔미토일/아라키도노일, 팔미토일/스테아로일, 팔미토일/팔미토일, 올레오일/스에타로일, 리놀레오일/팔미토일, 리놀레오일/스테아로일, 스테아로일/리놀레오일, 스테아로일/올레오일, 미리스토일/리놀레오일, 미리스토일/올레오일을 포함하는 군으로부터 선택되는 것인, 방법.
- 청구항 4에 있어서, 화학식 2의 화합물은 다른 모노아세틸디아실글리세롤 화합물이 실질적으로 없는 약학 조성물로 투여되는 것인, 방법.
- 청구항 5에 있어서, 화학식 2의 화합물은 다른 트리글레세리드 화합물이 실질적으로 없는 약학 조성물로 투여되는 것인, 방법.
- 청구항 1에 있어서, 점막염은 구강 점막염(예컨대, 구강 궤양) 또는 위장 점막염인, 방법.
- 청구항 7에 있어서, 상기 점막염은 재발성 구강 궤양인, 방법.
- 청구항 8에 있어서, 상기 재발성 구강 궤양은 화학요법, 방사선 치료, 호중성 백혈구 감소 상태 및 자가면역질환으로부터 선택되는 질병 또는 상태로 야기되는 것인, 방법.
- 청구항 9에 있어서, 상기 재발성 구강 궤양은 재발성 아프타성 구내염(RAS), 전신 홍반 루푸스(SLE) 및 베체트 병(BD)로부터 선택되는 질병으로 야기되는 것인, 방법.
- 청구항 1에 있어서, 점막염은 감염에 의해 야기되는 것인, 방법.
- 청구항 11에 있어서, 상기 감염은 단순성 포진 바이러스(HSV) 또는 칸디다 감염인, 방법.
- 청구항 1에 있어서, 점막염은 방사선 치료에 의해 전체 또는 일부분이 발생되는, 방법.
- 청구항 1에 있어서, 점막염은 화학요법에 의해 전체 또는 일부분이 발생되는 것인, 방법.
- 청구항 14에에 있어서, 점막염은 지브-애플리버셉트, 브렌툭시맙 베도틴, 디페리프론, 젬시타빈, 프랄라트렉세이트, 간시클로비르, 발간시클로버, 탈리도마이드, 로미뎁신, 보세프레비르, 데시타빈, 이마티닙, 토포테칸, 레날리도마이드, 파클리탁셀, 올란자핀, 이리노테칸, 팔리페리돈, 인터페론, 지질다당류, 타목시펜, 플레카이니드(a class 1C 심장 항부정맥제), 페니토인, 인도메타신, 프로필티오우라실, 카비마졸, 클로르프로마진, 트리메도프림/설파메톡사졸(코트리목사졸), 클로자핀, 티클로디핀 및 이들의 유도체, 시클로포스파미드, 메클로레타민, 클로람부실, 멜파란, 카르무스틴, 로무스틴, 프로카바진, 디카바진, 알트레타민, 시스플라틴, 카보플라틴, 악티노마이신 D, 에토포시드, 토포테칸, 이리노테칸, 독소루비신&다우노루비신, 6-메르캅토푸린, 6-티오구아닌, 이다루비신, 에피루비신, 미톡산트론, 아자티오프린, 2-클로로 디옥시아데노신, 수산화요소, 메토트렉사트, 5-플루오로우라실, 사이토신 아라비노시드, 아자시티딘, 플루다라빈 인산염, 빈크리스틴, 빈블라스틴, 비노렐빈, 파클리탁셀, 도세탁셀, 타목시펜, 페메트렉시드, 냅-파클리탁셀, 다사티닙, 프랄라트렉세이트, 데시타빈, 로미뎁신, 이마티닙, 레날리도마이드, 수니티닙, 옥살리플라틴, 아드리아마이신, 이포스파마이드, 시타라빈 및 탈리도마이드로부터 선택되는 약물에 의해 야기되는, 방법.
- 청구항 14에 있어서, 환자는 다른 치료의 부재시 점막염을 야기할 만큼의 충분한 복용량으로 화학요법을 받도록 의도되거나, 또는 화학요법으로 발생되는 점막염을 앓고 있는 것인, 방법.
- 청구항 1에 있어서, 점막염은 조혈 줄기 세포 이식 또는 말초 줄기 세포 주입과 관련되어 있는 것인, 방법.
- 청구항 1에 있어서, 상기 방법은 첨가제의 유효량을 순차적으로 또는 동시에, 이를 필요로 하는 환자에게 투여하는 것인 방법.
- 청구항 18에 있어서, 상기 첨가제는 팔리퍼민, 겔클레어, 질락틴, IL-6 길항제(예컨대, 항-IL-6 항체) 및 이들의 혼합물을 포함하는 군으로부터 선택되는 것인, 방법.
- 청구항 1에 있어서, 상기 방법은 저출력 레이저 치료(LLLT)를 포함하는 것인, 방법.
- 청구항 1에 있어서, 상기 치료는 예방을 위한 것인 방법.
- 청구항 1에 있어서, 화학식 1의 화합물은 약학 조성물로 투여되고, 상기 약학 조성물은 경구 또는 비경구 투여를 위한 고체, 액체, 젤 또는 현탁액 형태인, 방법.
- 청구항 22에 있어서, 화학식 1의 화합물은 경구 투여를 위한 약학 조성물의 형태로 투여되는 방법.
- 청구항 23에 있어서, 화학식 1의 화합물은 약학적으로 허용 가능한 희석제 또는 담체와 조합 또는 연계하여 화학식 1의 화합물을 포함하는 연질 젤라틴 캡슐인 약학 조성물의 형태로 투여되는, 방법.
- 청구항 24에 있어서, 화학식 1의 화합물의 총 일일 복용양은 250 mg 내지 2000 mg/day인, 방법.
- 청구항 25에 있어서, 상기 방법은 약학적으로 허용 가능한 산화방지제를 더욱 포함하는 방법.
- 청구항 26에 있어서, 상기 약학적으로 허용 가능한 산화방지제는 아스코르브 산(AA, E300), 토코페롤(E306), 갈산 프로필(PG, E310), 삼차부틸하이드로퀴논(TBHQ), 부틸히드록시아니솔(BHA, E320) 및 부틸레이티드하이드록시톨루엔으로부터 선택되는 방법.
- 청구항 27에 있어서, 화학식 1의 화합물은, 다른 트리글리세리드가 실질적으로 없고, 0.1 내지 3 mg의 약학적으로 허용 가능한 토코페롤 화합물을 함께, 250 내지 1000 mg의 화학식 1의 화합물을 포함하는 경구 투여를 위한 연질 젤라틴 캡슐의 형태로 투여되는 것인, 방법.
- 청구항 28에 있어서, 화학식 1의 화합물은, 다른 트리글리세리드가 실질적으로 없고, 1 mg의 약학적으로 허용 가능한 토코페롤 화합물을 함께, 250 또는 500 mg의 화학식 1의 화합물과 포함하는 경구 투여를 위한 연질 젤라틴 캡슐의 형태로 투여되고, 하루에 한번 또는 두 번 투여되는 것인, 방법.
- 청구항 29에 있어서, 화학식 1의 화합물은 화학식 2의 화합물인, 방법.
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2018544013A JP6824998B2 (ja) | 2015-11-09 | 2016-11-09 | 粘膜炎の治療方法 |
CA3004879A CA3004879C (en) | 2015-11-09 | 2016-11-09 | Method for treating mucositis |
EP16864555.4A EP3375440B1 (en) | 2015-11-09 | 2016-11-09 | Method for treating mucositis |
ES16864555T ES2905556T3 (es) | 2015-11-09 | 2016-11-09 | Método de tratamiento de la mucositis |
CN201680065316.6A CN108348497B (zh) | 2015-11-09 | 2016-11-09 | 用于治疗黏膜炎的方法 |
AU2016353600A AU2016353600B2 (en) | 2015-11-09 | 2016-11-09 | Method for treating mucositis |
KR1020177014195A KR101781993B1 (ko) | 2015-11-09 | 2016-11-09 | 점막염 치료용 조성물 |
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US14/959,750 US9808438B2 (en) | 2015-11-09 | 2015-12-04 | Method for treating mucositis |
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CN114081876A (zh) | 2014-05-15 | 2022-02-25 | 株式会社Enzychem生命科学 | 治疗白细胞减少症和血小板减少症的方法 |
US9808438B2 (en) * | 2015-11-09 | 2017-11-07 | Enzychem Lifesciences Corporation | Method for treating mucositis |
KR20190018317A (ko) * | 2017-08-14 | 2019-02-22 | 한국생명공학연구원 | 모노아세틸디아실글리세롤 화합물을 함유하는 슈도모나스 속 미생물 감염증의 예방 또는 치료용 조성물 |
WO2019106632A1 (en) * | 2017-11-30 | 2019-06-06 | Enzychem Lifesciences Corporation | Compositions for prevention or treatment of acute radiation syndrome |
KR20190063536A (ko) * | 2017-11-30 | 2019-06-10 | 주식회사 엔지켐생명과학 | 1-팔미토일-2-리놀레오일-3-아세틸글리세롤을 포함하는 급성 방사선 증후군의 예방 또는 치료용 조성물 |
CN111011309A (zh) * | 2020-03-03 | 2020-04-17 | 江西中医药大学 | 一种化疗药物致大鼠口腔溃疡模型建立方法及其应用 |
WO2023067501A1 (en) * | 2021-10-18 | 2023-04-27 | Enzychem Lifesciences Corporation | Compositions and methods for treating mucositis |
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ES2905556T3 (es) | 2022-04-11 |
CN108348497B (zh) | 2022-09-30 |
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KR101781993B1 (ko) | 2017-09-26 |
CN108348497A (zh) | 2018-07-31 |
AU2016353600B2 (en) | 2020-01-30 |
US20170128404A1 (en) | 2017-05-11 |
CA3004879A1 (en) | 2017-05-18 |
JP2021063125A (ja) | 2021-04-22 |
EP3375440B1 (en) | 2022-01-12 |
CA3004879C (en) | 2021-05-18 |
AU2016353600A1 (en) | 2018-05-10 |
JP2022123094A (ja) | 2022-08-23 |
KR20170066666A (ko) | 2017-06-14 |
JP6824998B2 (ja) | 2021-02-03 |
EP3375440A2 (en) | 2018-09-19 |
US9808438B2 (en) | 2017-11-07 |
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