JP6824998B2 - 粘膜炎の治療方法 - Google Patents
粘膜炎の治療方法 Download PDFInfo
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- JP6824998B2 JP6824998B2 JP2018544013A JP2018544013A JP6824998B2 JP 6824998 B2 JP6824998 B2 JP 6824998B2 JP 2018544013 A JP2018544013 A JP 2018544013A JP 2018544013 A JP2018544013 A JP 2018544013A JP 6824998 B2 JP6824998 B2 JP 6824998B2
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Landscapes
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Description
例えば、
1.1. R1及びR2は、それぞれ独立して、パルミトイル、オレオイル、リノレオイル、リノレノイル、ステアロイル、ミリストイル、及びアラキドノイルからなる群から選択される、方法1
1.2. R1及びR2(R1/R2)は、オレオイル/パルミトイル、パルミトイル/オレオイル、パルミトイル/リノレオイル、パルミトイル/リノレノイル、パルミトイル/アラキドノイル、パルミトイル/ステアロイル、パルミトイル/パルミトイル、オレオイル/ステアロイル、リノレオイル/パルミトイル、リノレオイル/ステアロイル、ステアロイル/リノレオイル、ステアロイル/オレオイル、ミリストイル/リノレオイル、ミリストイル/オレオイルからなる群から選択される、方法1又は1.1.
1.3. 化学式1の化合物は、化学式2の化合物であるものである、前述の方法;
再発性口腔潰瘍(ROU)を患っている20代〜80代の患者総44人(女性34人、男性10人、病名;RAS(26人)、BD(27人)、SLE(1人)、平均年齢:49.3±9.0)が、本研究に登録された。ROUの診断は、病歴及び医師による口腔粘膜の診察を基に行われた。再発性口腔潰瘍には、次の3つの病状を含めることにした:再発性アフタ性口内炎(RAS)、ベーチェット病(BD)、全身性エリテマトーデス(SLE)。基準値の評価を完了した後、250mgのPLAGを2〜4週間1日に2回(250mgのPLAG/錠剤、500mg/day)患者に経口投与した。患者の再発性口腔潰瘍の変化は、次の3つの測定手段を含む、自己報告スコアリングシステム(合計12点)を使用して、治療後2週目又は4週目に評価した:潰瘍の頻度の変化(リッカート0−4)、潰瘍の重症度の変化:痛み及びサイズ(リッカート0−4)、及び潰瘍の持続期間の変化(リッカート0−4)。ROUの症状は、3つのスコアの合計が5点を超えた場合、大幅に改善されたものとみなした。その結果を表1に示した。
(i)PLAG及び(ii)a−トコレロールを含有し、本明細書に記載の方法で使用するための軟質ゼラチンカプセルの例は、以下の組成を有する:
Claims (26)
- 化学式2
- 化学式2の化合物は、他のモノアセチルジアシルグリセロールを含有しない医薬組成物として投与されるものである、請求項1に記載の医薬組成物。
- 化学式2の化合物は、他のトリグリセリド化合物を含有しない医薬組成物として投与されるものである、請求項1に記載の医薬組成物。
- 粘膜炎は、口腔粘膜炎又は消化管粘膜炎である、請求項1に記載の医薬組成物。
- 粘膜炎は、口腔粘膜炎である、請求項4に記載の医薬組成物。
- 前記粘膜炎は、再発性口腔潰瘍であるものである、請求項5に記載の医薬組成物。
- 前記再発性口腔潰瘍は、化学療法、放射線療法、好中球性減少状態、及び自己免疫疾患から選択される疾患又は状態によって引き起こされるものである、請求項6に記載の医薬組成物。
- 前記再発性口腔潰瘍は、再発性アフタ性口内炎(RAS)、全身性エリテマトーデス(SLE)、及びベーチェット病(BD)から選択される疾患によって引き起こされるものである、請求項7に記載の医薬組成物。
- 粘膜炎は、感染症によって引き起こされるものである、請求項1に記載の医薬組成物。
- 前記感染症は、単純ヘルペスウイルス(HSV)又はカンジダ感染である、請求項9に記載の医薬組成物。
- 粘膜炎は、放射線治療によって、全体的又は部分的に引き起こされるものである、請求項1に記載の医薬組成物。
- 粘膜炎は、化学療法によって、全体的又は部分的に引き起こされるものである、請求項1に記載の医薬組成物。
- 粘膜炎は、ジブ−アフリベルセプト、ブレンツキシマブベドチン、デフェリプロン、ゲムシタビン、プララトレキサート、ガンシクロビル、バルガンシクロビル、サリドマイド、ロミデプシン、ボセプレビル、デシタビン、イマチニブ、トポテカン、レナリドマイド、パクリタキセル、オランザピン、イリノテカン、パリペリドン、インターフェロン、リポ多糖、フレカイニド(クラス1Cの抗不整脈薬)、フェニトイン、インドメタシン、プロピルチオウラシル、カルビマゾール、クロルプロマジン、トリメトプリム/スルファメトキサゾール(コトリモキサゾール)、クロザピン、チクロジピン、及びこれらの誘導体、シクロホスファミド、メクロレタミン、クロラムブシル、メルファラン、カルムスチン、ロムスチン、プロカルバジン、ダカルバジン、アルトレタミン、シスプラチン、カルボプラチン、アクチノマイシンD、エトポシド、トポテカン、イリノテカン、ドキソルビシン及びダウノルビシン、6−メルカプトプリン、6−チオグアニン、イダルビシン、エピルビシン、ミトキサントロン、アザチオプリン、2−クロロデオキシアデノシン、ヒドロキシウレア、メトトレキサート、5−フルオロウラシル、シトシンアラビノシド、アザシチジン、リン酸フルダラビン、ビンクリスチン、ビンブラスチン、ビノレルビン、パクリタキセル、ドセタキセル、タモキシフェン、ペメトレキセド、nab−パクリタキセル、ダサチニブ、プララトレキサート、デシタビン、ロミデプシン、イマチニブ、レナリドミド、スニチニブ、オキサリプラチン、アドリアマイシン、イホスファミド、シタラビン、及びサリドマイドから選択される薬物によって引き起こされるものである、請求項12に記載の医薬組成物。
- 患者は、他の治療の不在下で粘膜炎を引き起こすのに十分な用量で化学療法又は放射線治療を受けようとしているか、もしくは、化学療法又は放射線療法の結果として粘膜炎を患っているものである、請求項13に記載の医薬組成物。
- 粘膜炎が、造血幹細胞移植又は末梢幹細胞注入によって引き起こされるものである、請求項1に記載の医薬組成物。
- 添加剤の有効量が前記患者に順次又は同時に更に投与される、請求項1に記載の医薬組成物。
- 前記添加剤は、パリフェルミン、アミホスチン、ゲルクレア、ジラクチン、IL−6拮抗薬、及びこれらの混合物からなる群から選択されるものである、請求項16に記載の医薬組成物。
- 低出力レーザー治療(LLLT)と同時投与される、請求項1に記載の医薬組成物。
- 前記医薬組成物は、経口又は非経口投与のための固体、液体、ゲル、又は懸濁液の形態である、請求項1に記載の医薬組成物。
- 経口投与のための、請求項19に記載の医薬組成物。
- 薬学的に許容可能な希釈剤又は担体と組み合わせて又は連携して、化学式2の化合物を含有する軟質ゼラチンカプセルの形態である、請求項20に記載の医薬組成物。
- 該組成物の総服用量は、250mg〜2000mg/日である、請求項21に記載の医薬組成物。
- 薬学的に許容可能な酸化防止剤をさらに含有する、請求項22に記載の医薬組成物。
- 前記薬学的に許容可能な酸化防止剤は、アスコルビン酸(AA、E300)、トコフェロール(E306)、没食子酸プロピル(PG、E310)、tert−ブチルヒドロキノン(TBHQ)、ブチルヒドロキシアニソール(BHA、E320)、及びブチルヒドロキシトルエン(BHT、E321)から選択されるものである、請求項23に記載の医薬組成物。
- 他のトリグリセリドを含有せず、薬学的に許容可能なトコフェロール化合物0.1〜3mgとともに、化学式2の化合物を250〜1000mg含有し、経口投与のために軟質ゼラチンカプセルの形で投与されるものである、請求項24に記載の医薬組成物。
- 他のトリグリセリドを含有せず、薬学的に許容可能なトコフェロール化合物1mgとともに、化学式2の化合物を250又は500mg含有し、経口投与のために軟質ゼラチンカプセルの形で、1日に1回又は2回投与されるものである、請求項25に記載の医薬組成物。
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