Classifications

• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/22—Peroxides; Oxygen; Ozone
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
  • A61K8/24—Phosphorous; Compounds thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/34—Alcohols
  • A61K8/345—Alcohols containing more than one hydroxy group
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
  • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K8/00—Cosmetics or similar toiletry preparations
  • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
  • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
  • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
  • A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
  • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
  • A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures

Definitions

• the present invention relates to a composition for tooth bleaching.
• tooth whiteness is considered to be an important factor in cosmetics, and the demand for tooth bleaching has increased in recent years.
• a method for bleaching teeth a method is generally used in which a composition containing a bleaching component is applied to the pigment deposited on the teeth, and the pigment is colorless or removed by its action.
• composition for tooth bleaching for example, a composition comprising magnesium silicate sodium, urea peroxide, polyhydric alcohol, and a thickener capable of swelling in the polyhydric alcohol is known (for example, Patent Document 1). reference.).
• Patent Document 1 a composition comprising magnesium silicate sodium, urea peroxide, polyhydric alcohol, and a thickener capable of swelling in the polyhydric alcohol.
• this composition does not contain water, the penetrating power of the bleaching component to the tooth surface is weak and the bleaching ability is low.
• the storage stability is that bleaching components such as hydrogen peroxide and urea peroxide are decomposed during storage (when not in use) and the bleaching performance of the composition is reduced. There was a sex problem.
• a paste-like first component in which a powdered hydrogen peroxide polyvinylpyrrolidone complex is blended in a liquid component, a catalyst for activating hydrogen peroxide in the liquid component, and A pasty dental bleaching material comprising a pasty second component containing a thickener is disclosed (for example, see Patent Document 2).
• the hydrogen peroxide polyvinyl pyrrolidone complex is a complex, the amount of radical generation is small compared to normal hydrogen peroxide, and there is a problem that sufficient bleaching performance cannot be obtained after long-term storage.
• the storage stability problem can be solved by using a two-component system, but there is a problem that a mixing operation is required at the time of use, and the operation becomes complicated.
• an object of the present invention is to provide a tooth bleaching composition having a high bleaching performance and a good storage stability while being a one-paste system.
• the present inventors include a bleaching component, a metal ion chelating agent, water, and a polyhydric alcohol, and the weight ratio of water to the polyhydric alcohol is within a specific range. And if the total amount of water and polyhydric alcohol is in a specific range, it has been found that a tooth bleaching composition having high bleaching performance and good storage stability can be provided while being a one-paste system.
• the present invention has been completed.
• the present invention is a tooth bleaching composition
• It is a composition for bleaching teeth, characterized in that it is 5: 1 to 20: 1, and the total amount of the water and the polyhydric alcohol is 50% by weight or more and 85% by weight or less in the composition. .
• the tooth bleaching composition according to the present invention is an excellent tooth bleaching composition that is a one-paste system, has high bleaching performance while containing water, and does not deteriorate in quality even after long-term storage.
• the tooth bleaching composition according to this embodiment is a tooth bleaching composition containing a bleaching component, a metal ion chelating agent, water, and a polyhydric alcohol, and the weight ratio of the water and the polyhydric alcohol is water.
• Polyhydric alcohol 3.5: 1 to 20: 1, and the total amount of the water and the polyhydric alcohol is 50 wt% or more and 85 wt% or less in the composition. It is a composition for tooth bleaching.
• the bleaching component contained in the tooth bleaching composition according to the present embodiment is one that bleaches or removes the pigment adhering to the tooth surface.
• it is a substance capable of generating radicals
• a typical one is a peroxide.
• hydrogen peroxide, urea peroxide, perborate, percarbonate, perphosphate, calcium peroxide, magnesium peroxide and the like can be mentioned.
• a substance that does not generate hydrogen peroxide such as chlorous acid or hypochlorous acid may be used.
• hydrogen peroxide or urea peroxide is particularly preferable. Two or more of these may be used simultaneously.
• it is preferable not to mix a peroxide that is a complex such as a hydrogen peroxide polyvinyl pyrrolidone complex, because it tends to generate less radicals than a peroxide that is not a complex.
• the blending amount of the bleaching component is preferably 1% by weight or more and 30% by weight or less in the tooth bleaching composition. By setting it to 1% by weight or more, the bleaching power can be maintained, and by setting it to 30% by weight or less, storage stability can be maintained. More preferably, it is 3 to 25 weight%.
• the metal ion chelating agent contained in the composition for tooth bleaching according to this embodiment may be mixed as a trace impurity in the composition, and the storage stability of the composition is lowered by promoting the decomposition of the bleaching component. It has an action of chemically taking in metal ions such as platinum ions, iron ions, manganese ions and the like, and has an action of improving the storage stability of the composition.
• the metal ion chelating agent include condensed phosphoric acid and salts thereof.
• metaphosphoric acid tripolyphosphoric acid, tetrapolyphosphoric acid, pyrophosphoric acid, hexametaphosphoric acid, sodium metaphosphate, sodium tripolyphosphate, sodium tetrapolyphosphate
• metal ion chelating agents other than condensed phosphoric acid include citric acid, glycine, ethylenediaminetetraacetic acid, succinic acid, adipic acid, and salts thereof. Two or more of these may be used simultaneously.
• condensed phosphoric acid and salts thereof are particularly preferable because they tend to be excellent in storage stability particularly when a large amount of water is added.
• the compounding amount of the metal ion chelating agent is preferably 0.1% by weight or more and 20% by weight or less in the tooth bleaching composition.
• the content is 0.1% by weight or more, the storage stability of the bleaching component can be maintained, and when the content is 20% by weight or less, the bleaching power can be maintained. More preferably, they are 0.5 weight% or more and 10 weight% or less.
• the total amount of the monohydric alcohol is 50% by weight or more and 85% by weight or less in the composition. If the blending amounts of water and polyhydric alcohol are within the above ranges, an excellent tooth bleaching composition with high bleaching performance and no deterioration in quality even after long-term storage even though it is a one-paste system.
• Polyhydric alcohol refers to an alcohol having two or more hydroxyl groups in one molecule.
• examples of the polyhydric alcohol include glycerin, diglycerin, polyglycerin, propylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol, diethylene glycol, polyethylene glycol, polyethylene glycol monomethyl ether, 1,2-pentanediol, 1,2- Examples include hexanediol, 1,2-octanediol, sorbitol, mannitol and the like. Two or more of these may be used simultaneously.
• Can keep sex. More preferably, water: polyhydric alcohol 5: 1 to 8: 1.
• the total amount of water and polyhydric alcohol blended in the composition is 50% by weight or more and 85% by weight or less in the composition.
• the bleaching power can be maintained, and by setting it to 85% by weight or less, storage stability can be maintained. More preferably, it is 55 to 80 weight%.
• the amount of water is preferably 50% by weight or more and 75% by weight or less in the composition because the bleaching power becomes higher. More preferably, it is 55 to 70 weight%.
• the tooth bleaching composition according to this embodiment can also contain a solvent other than water and polyhydric alcohol.
• solvents other than water and polyhydric alcohols include monohydric alcohols such as methanol, ethanol, 1-propanol, 2-propanol, 2-methyl-2-propanol, acetone, hexane, benzene, toluene, and the like.
• the solvent other than water and polyhydric alcohol is preferably 10% by weight or less in the composition. . More preferably, it is 5 weight% or less.
• the tooth bleaching composition according to this embodiment may further contain a thickener.
• a thickener By including a thickener, viscosity is imparted to the tooth bleaching composition, and operability can be improved.
• thickeners include sodium glucose glucose, sodium alginate, carboxymethylcellulose, sodium carboxymethylcellulose, carboxymethylcellulose calcium, carboxypolymethylene, methyl vinyl ether / maleic anhydride copolymer, dimethylpolysiloxane, sodium starch glycolate, starch Organic thickeners such as sodium phosphate ester, sodium polyacrylate, methylcellulose, crystalline cellulose, hydroxyethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, polyvinylpyrrolidone, magnesium sodium silicate, lithium sodium magnesium silicate, acrylic acid / Behenic acid copolymer, calcium carbonate, calcium silicate, ke Magnesium, silica powder, various glasses, amorphous hydrous silicic acid, inorganic thickeners such as fumed
• the blending amount when blending the thickener is preferably 0.5% by weight or more and 30% by weight or less in the composition. By making it 0.5% by weight or more, the effect of increasing the viscosity of the tooth bleaching composition can be made sufficient. For example, it is easy to stay on the tooth surface, and by making it 30% by weight or less, an appropriate viscosity is obtained. Can be obtained. More preferably, it is 1 to 25 weight%.
• the tooth bleaching composition according to this embodiment may further contain a colorant.
• the visibility of a composition improves by mix
• the colorant include titanium oxide, silicon dioxide, zinc oxide, aluminum oxide, magnesium oxide, zirconium oxide and the like. Two or more of these may be used simultaneously.
• the blending amount when blending a colorant in the tooth bleaching composition is preferably 0.01% by weight or more and 5% by weight or less. By making it 0.01% by weight or more, the coloring effect of the paste can be made sufficient, and by making it 5% by weight or less, storage stability can be maintained.
• the tooth bleaching composition according to this embodiment preferably has a pH adjusted to 5.5 or more and 9.5 or less. By setting the pH to 5.5 or more, decalcification of the teeth can be prevented, and by setting the pH to 9.5 or less, the storage stability of the tooth bleaching composition can be maintained.
• a pH adjusting agent can be further included.
• the pH adjuster include disodium phosphate, potassium hydroxide, sodium hydroxide, ammonium hydroxide, sodium carbonate, monoethanolamine, diethanolamine, and triethanolamine. Two or more of these may be used simultaneously.
• the blending amount is preferably 0.1% by weight or more and 25% by weight or less.
• the pH adjustment effect can be sufficient, and by setting the content to 25% by weight or less, storage stability can be maintained.
• a fragrance, a pigment, a stabilizer, a solvent, and the like may be added to the tooth bleaching composition according to this embodiment.
• the mixture was allowed to stand at 37 ° C. for 2 hours, and 25 ml of the supernatant was gently collected.
• the supernatant was subjected to oxidation-reduction titration in accordance with “Test method for hydrogen peroxide concentration” in JIS T 6542: 2013 “Tooth surface bleaching material”. At this time, since the concentration was lower than that for a normal concentration measurement, titration was performed using a 0.01 M sodium thiosulfate solution.
• the amount of hydrogen peroxide obtained was multiplied by 1.2 and converted to calculate “the amount of hydrogen peroxide released into 30 mL of distilled water”.
• the amount of hydrogen peroxide contained in 0.02 g of the tooth bleaching composition was determined by oxidation-reduction titration in “Testing method of hydrogen peroxide concentration” in JIS T 6542: 2013 “Tooth surface bleaching material”.
• Bleaching component release rate (%) (Amount of hydrogen peroxide released in 30 mL of distilled water) / (Amount of hydrogen peroxide contained in 0.02 g of tooth bleaching composition) ⁇ 100 From the viewpoint of bleaching performance, the bleaching component release rate is preferably 30% or more.
• ⁇ Tooth bleaching test> After excising the root of the extracted bovine anterior tooth, the pulp was removed and used as a test piece for the bleaching test. First, the color tone (CIE L * a * b * value) of the test piece surface was measured. Subsequently, after applying each prepared tooth bleaching composition, it was stored for 2 hours in an environment of a temperature of 37 ° C. and a relative humidity of 100%, and then washed with water.
• ⁇ Eab * is 8 or more
• Each prepared tooth bleaching composition was filled into a syringe and then allowed to stand at 23 ° C. On the first day and the predetermined number of days, oxidation-reduction titration was performed in accordance with “Test method for hydrogen peroxide concentration” in JIS T 6542: 2013 “Tooth surface bleaching material”. The number of days required for the hydrogen peroxide concentration to fall below 70% of the initial concentration was determined.
• the number of days is preferably 350 days or more.
• ⁇ PH measurement> 1 g of each prepared tooth bleaching composition was completely dissolved in 19 g of distilled water, and the pH was measured with a pH meter.
• the bleaching component release rate is 30% or more, and the evaluation result of the tooth bleaching test is “AA” or “A "It was good.
• the number of days required for the hydrogen peroxide concentration in the storage stability test to fall below 70% of the initial concentration was 350 days or more.

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• Oral & Maxillofacial Surgery (AREA)
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• 2016
  • 2016-07-13 CN CN201680044653.7A patent/CN107920966B/zh active Active
  • 2016-07-13 WO PCT/JP2016/070694 patent/WO2017022436A1/ja not_active Ceased
  • 2016-07-13 US US15/746,556 patent/US10874596B2/en active Active
  • 2016-07-13 EP EP16832715.3A patent/EP3329900B1/en active Active
  • 2016-07-13 KR KR1020187002774A patent/KR102102116B1/ko active Active
  • 2016-07-13 JP JP2017532456A patent/JP6651525B2/ja active Active
• 2019
  • 2019-12-02 JP JP2019218230A patent/JP7049307B2/ja active Active

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