WO2016163649A1 - Complément alimentaire de santé pour atténuer des symptômes de maladie articulaire, et son procédé de préparation - Google Patents

Complément alimentaire de santé pour atténuer des symptômes de maladie articulaire, et son procédé de préparation Download PDF

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Publication number
WO2016163649A1
WO2016163649A1 PCT/KR2016/002434 KR2016002434W WO2016163649A1 WO 2016163649 A1 WO2016163649 A1 WO 2016163649A1 KR 2016002434 W KR2016002434 W KR 2016002434W WO 2016163649 A1 WO2016163649 A1 WO 2016163649A1
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weight
parts
food supplement
health food
health
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PCT/KR2016/002434
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English (en)
Korean (ko)
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김경일
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김경일
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L13/00—Meat products; Meat meal; Preparation or treatment thereof
    • A23L13/50—Poultry products, e.g. poultry sausages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health

Definitions

  • the present invention relates to a dietary supplement for alleviating symptoms of joint disease and a method of manufacturing the same.
  • Health supplements are a group of foods produced by the process of concentrating, refining, and mixing special foods or special ingredients beneficial to our bodies. Such dietary supplements may be called special-purpose foods consumed by consumers for the purpose of health promotion.
  • health supplement foods are foods that are expected to be effective in maintaining and improving health as compared to ordinary foods, and mean foods that are considered to be effective in maintaining human health. Food consumed with anticipation for prevention and treatment, usually in a commercial sense.
  • Dietary supplements contain many ingredients, and ingestion of multiple products at the same time can cause unexpected effects in the body because each of them interferes with each other's absorption or causes chemical reactions. Therefore, the choice of dietary supplements for each body is important. Even good health supplements can be toxic in certain diseases, so make sure you know what you have before you eat a dietary supplement.
  • Joints are structured to connect bones to bones, to move bones smoothly, and to reduce the force and friction applied to the bones.
  • the symptoms of these joint problems are called arthritis.
  • the causes of arthritis vary from aging, genetic factors, poor lifestyle, immunity disorders, traffic accidents, trauma and obesity.
  • Joint diseases can be divided into rheumatoid arthritis, degenerative arthritis, ankylosing spondylitis, gouty arthritis, and the like.
  • Representative arthritis is rheumatoid arthritis due to immune disorders. It is a condition in which the joint attacks the immune system and is damaged, starting with small joints such as fingers and spreading to the wrists, elbows, shoulders, knees, and ankles. Symptoms are more severe, usually in the morning and on cloudy days. Second is degenerative arthritis due to aging. Degenerative arthritis is the most common symptom of arthritis, with severe pain, swelling, and burning in the joints. In addition, the joints will be deformed as long as the symptoms are severe in the afternoon or evening.
  • Gouty arthritis caused by uric acid metabolism disorder. Gouty arthritis is a disease caused by the accumulation of uric acid in the blood. Pain occurs when the big toe or the distal part of the body swells in the peripheral blood circulation.
  • Treatment of arthritis is the first to relieve inflammation and pain. To alleviate the symptoms, improve pain in the blood circulation around the joints and remove the waste to reduce pain. In addition, cartilage and surrounding bones are prevented from being lost to prevent the progression of arthritis, supplying nutrition to the joints and smoothing the flow of joint fluid to treat arthritis. And cartilage, muscles, and ligaments around the joints must be treated together to completely eliminate pain. Simple analgesic suppression can aggravate the development of arthritis and lead to greater illness.
  • Korean Patent Publication No. 2003-0061764 suggests that ingestion of a ring consisting of green rust, dew, earth and sand, dandelion and safflower seed powder and their concentrates will allow bone and cartilage to grow and soften joints.
  • 2006-0101704 covers osteoporosis and rheumatoid arthritis when taking a ring consisting of Hyangbuja, Motherwort, Sukjihwang, Angelica, Cheongung, Potion, Baekbongryeong, Dansam, Baekbuja, Osuyu, Cornus, Taxa, Bark Peel, Broiler, Straw, Deodeok and Malt. It is disclosed that the effects of preventing and improving symptoms of joint diseases, such as.
  • Republic of Korea Patent Registration No. 10-1075067 is a concentrated liquid obtained by extracting wild ginseng from Goro bark sap, three hundred seconds with cartilage and joint improvement function, poisonous, thawed blood, gilyeong, rapeseed, Astragalus, hyssop, tofu, red pepper, safflower, organ
  • a health food molded into capsules or pills with at least one additive selected from herbal medicines and additives such as safflower seed, glucosamine, collagen, etc. has been presented.
  • chicken feet are also known to be useful in conjunction with foods such as crucible or tail tang in relation to joint diseases.
  • Joint disease of the cactus eg, millennial plant
  • chicken feet are known, but there are no examples of using both.
  • Patent Document 1 Korean Patent Publication No. 2003-0061764
  • Patent Document 2 Korean Patent Publication No. 2006-0101704
  • Patent Document 3 Korean Patent Registration No. 10-1075067
  • Patent Document 4 Korean Patent Registration No. 10-0666283
  • Patent Document 5 Korean Patent Registration No. 10-1374538
  • Patent Document 6 Republic of Korea Patent Publication No. 2014-0069789
  • the applicant has conducted various studies to manufacture health supplements that can maintain joint health and relieve symptoms of joint diseases even if taking short term without side effects, and selected various materials including chicken feet and cactus.
  • the mixture is prepared in a specific content ratio, it was confirmed that the symptoms related to joint disease can be alleviated to complete the present invention.
  • It provides a method for producing a dietary supplement comprising the step of performing a second filtration process.
  • the first heating process is characterized in that carried out for 7 to 15 hours at 80-100 °C.
  • the second heating process is characterized in that performed for 4 to 10 hours at 80-100 °C.
  • the present invention provides a dietary supplement prepared through the above steps.
  • the health supplement is characterized in that it is formulated in the form of liquid, pill, granule, tablet, powder, or capsule.
  • the dietary supplement according to the present invention is effective, safe and effective in alleviating symptoms associated with joint disease, that is, inflammation and pain, by deriving an optimal composition ratio of the corresponding component. Since these supplements are made of only natural ingredients, they are quickly absorbed into the body to restore damaged cartilage to increase elasticity, to suppress or treat inflammation, as well as to reduce inflammation and swelling in the joints and to relieve joint pain.
  • the present invention provides a functional dietary supplement that can alleviate the symptoms associated with joint disease.
  • Joint diseases referred to herein include rheumatoid arthritis, degenerative arthritis, ankylosing spondylitis, and gouty arthritis.
  • the dietary supplement referred to in the present specification is intended to be consumed in anticipation of its usefulness in terms of physical and physiological aspects of the body, or may be used as an ingredient in a food material as it is, or a specific component contained therein is separated or extracted, concentrated, It means the food manufactured and processed by the method of purification, mixing, etc.
  • the dietary supplement according to the present invention provides nutrition to bones and joints, the surrounding muscles and ligaments, restores damaged soft tissues, promotes blood circulation around the joints, and improves the joint environment according to the elasticity of cartilage. It not only inhibits or treats inflammation associated with joint disease, but also reduces inflammation and swelling in joints and relieves joint pain.
  • the health supplement according to the present invention is prepared from mulberry root bark, brier roots, cucumber trees, ganoderma lucidum, cheonggung, donkey, licorice, and jujube with chicken feet and cactus. Each composition is explained in more detail below.
  • Collagen is a protein that acts as a major component of cells and the cells that make up the cartilage tissues to move the spine or knees flexibly.
  • the collagen is known to be effective in the prevention of osteoporosis, neuralgia, arthritis, knee joint pain, used in the manufacture of health supplements in the present invention to restore the worn cartilage while making the skin tissue elastic and various symptoms and pain caused by joint diseases Can alleviate
  • Cactus (cactus) is more than 10,000 species in the world, Opuntia ( palm cactus ) is growing in Korea. These prickly pear cacti are Opuntia ficus - indica and Opuntia Humifusa ), preferably che choireoncho , and may be used alone or mixed with cheonnyeoncho if necessary. Commonly grown in Jeju-do, etc. is commonly called baeknyeoncho cactus, and in winter, it is called cheonnyeoncho cactus. The cheonnyeoncho is used for all parts of the roots, seeds, stems, edible food, and remove the thorns and use the dried ones.
  • the fruit has vitamins, amino acids, isorametine, etc., has excellent anti-inflammatory action, collagen and calcium in the stem, and saponin in the root, so it is excellent in anti-inflammatory and analgesic effect, and used in the health supplement of the present invention. Can be.
  • Mulberry is originally grown to strike silkworms, but most of the roots, berries, and leaves are used as medicinal herbs. There are about 10 species of mulberry in the world. In Korea, Morus bombycis and Morus bombycis for. Dissecta ), Mongolian Mulberry (Mongolia, Morus mongolica ), Mulberry, Morus tiliaefolia Makino ), Cudrania (Cucus, Cudrania tricuspidata ) is growing. Mulberry prevents diabetes, has an excellent effect of dropping blood sugar of diabetics, preferably in the present invention, mulberry ( Morus) rooty bark obtained from bombycis ), and if necessary, cane, mulberry, mongolia, cedar, and cuddle.
  • mulberry Morus rooty bark obtained from bombycis
  • Mulberry root bark is called erectary baekpi ( ⁇ ⁇ ) or sangbaekpi ( ⁇ ) has been used as a medicinal herb since ancient times, scrapes the outer skin from the mulberry root and peels off the white bark inside and uses it in the sun.
  • ⁇ Chericle Gangmok ( ⁇ ) '' it is applied as a medicine, and all of the upper lobes, epithelium, and upper limbs that drive the wind, excrete waste heat, and facilitate joint communication all have beneficial effects. It is recorded.
  • the mulberry root bark contains ingredients such as morusin, molasin, melberopran, peony, and has the effect of smoothly activating blood, benefiting the joints when the joint is painful and swollen.
  • Rosa multiflora is a deciduous shrub belonging to the Rosaceae family, also known as wild rose or wild rose.
  • the flower is rose, the liquid distilled from the flower is rose, the leaf is rose leaf, the branch is rose, and the root is rose root.
  • red fruit is called Youngsil ( ⁇ ⁇ ), each with a slightly different taste and character, and is used in different medicines.
  • Youngsil ( ⁇ ⁇ ) each with a slightly different taste and character, and is used in different medicines.
  • the 'prime root' also called rose root, 'Taste and bitter taste, cool nature, customary joint pain, arthritis, facial nerve bullets, half body insomnia and take it' is recorded.
  • Brier roots are harvested in autumn and used in the sun. They take the heat down and promote blood circulation.
  • Acantho Panax is a deciduous broad-leaved shrub belonging to the family Elderaceae, such as ginseng.
  • the Ogapi tree includes the bark of the roots, stems and branches of the Ogapi tree or other related plants belonging to the Oga family.
  • Ogapi increases the body's energy, relieves pain in the heart and abdomen, relieves soreness in the lower back, spine and legs, strengthens muscles and bones, clears blood in the body, and ages. It is said that it has various functions such as suppressing.
  • Ogapi In oriental medicine, one of the causes of arthralgia is that the air enters the air and obstructs the movement of blood, and Ogapi removes the custom, strengthens the musculature, and treats various arthritis. It is known to control the species caused by moisture, and to protect the liver and kidneys, thereby controlling the musculoskeletal force, atrophy and weakness. From a modern point of view, Ogapi has an ingredient called Acontoside D, which is said to be effective in strengthening bones and strengthening muscles, which is good for arthritis or joint syndrome.
  • Ganoderma lucidum mushroom lucidum is an annual mushroom belonging to Basidiomycetes, P. locust, and Buloba. Because it is hard, it is impossible to eat directly, dried, medicinal, and in oriental medicine, tonic, Jinhae, small species ( ⁇ ), such as nervous breakdown, heart disease, high blood pressure, various cancers are used.
  • In the dietary supplement of the present invention has an anti-inflammatory action to reduce inflammation.
  • Cnidium officinale Makino is a perennial herb that dries the rhizome of a palace, a palace, or a crossbow.
  • the rhizome of the uterus contains 1% to 2% of essential oil components (cnidilide, neocnilide, liqueustilide, cheongung acid, butyl phthalide, hormonal acid ester).
  • Efficacy of the above-mentioned archery includes an active blood circulation ( ⁇ ⁇ ⁇ ) and a painful pain ( ⁇ ⁇ : to remove the sarcasm to treat pain). It is used for general pain, horse's neck, and paralysis caused by blood vessel obstruction caused by customs or gas and malnutrition of blood to muscle.
  • Angelica is a perennial herb in the Apiaceae, also known as Angelica gigas (Angel gigas , Angelica gigas ), and Angelica gigas (Angels, Angelica acutiloba ), among which, the present invention uses the Angelica gigas.
  • the donkey is a generic name such as dried thorn, guinea herb, Todang gui, Soongumcho, Singamchae, Chosun Donkey, Singamcho, Chamsangui Root, and Soongchocho Root. .
  • the donkey is used to dig the roots in late autumn to remove the stems, leaves, and soil clean and then shade dried in a well-ventilated place for several days.
  • Licorice ( Glycyrrhiza uralensis Fischer ) is a perennial herbaceous plant belonging to the legume and used to dry its roots.
  • the licorice is called licorice because its taste is sweet, releasing the toxicity of all medicines, cough and phlegm, and has the effect of neutralizing all medicines.
  • licorice governs the heat and fraud of chapter 5 and six, normalizes the physiology of eyes, nose, mouth, ears and faeces, communicates all blood veins, strengthens muscles and bones, It is written to improve nutrition.
  • recent studies have shown that licorice inhibits gastric acid secretion by promoting the release of interferon in the body and protects the gastric mucosa. Yes, it is reported.
  • Jujube is the sea buckthorn and Zizyphus zizyphus ) fruit, also called redness ( ⁇ ). When the fruit ripens in autumn, pick it up and dry it in the sun, or bake it until it's softened and dry it in the sun. In the 'agreement bogam' is a strong sense of intestinal strength to help the common sense and help the meridians to see the shortage.In the 'Hanjeseongbang room' to relax the inside, protect the spleen, heal the essence and lack of energy, all kinds of medicine It is said to harmonize the nature of.
  • the jujube contains protein, sugars, organic acids, mucilage, vitamins A, B2, C, trace amounts of calcium, phosphorus, iron, etc., helping the heart to improve blood circulation and stabilize nerves. There is this.
  • cactus in addition to the chicken feet, cactus, mulberry root bark, brier roots, Ogapi, Ganoderma lucidum, Cheongung, Angelica, licorice, jujube in addition to various compositions that can alleviate or improve the symptoms of joint diseases may be further added.
  • Health supplements having the composition described above can be prepared in various forms.
  • the dietary supplement of the present invention refers to a food to be taken in daily, and is a general term for eating and drinking. Therefore, the form of the dietary supplement in the present invention is not particularly limited. For example, it may be prepared in various forms including beverages, pills, granules, tablets, powders, capsules, and the like, which are easy to carry and easy to ingest anytime, anywhere.
  • the dietary supplement of the present invention may be formulated in liquid form and processed into pouches in batches for drinking.
  • the mixture is heated by mixing chicken feet, mulberry root bark, brier roots, staghorn, ganoderma lucidum and cactus with water in a container.
  • the content ratio of each composition is a range for maximizing the efficacy of each, if the content is less than or above the range can not secure the effect to be obtained in the present invention, it is used properly within the above range.
  • the purchased chicken feet are stripped of the yellow shells surrounding the chicken feet using a stripper, and the shells are discarded.
  • the chicken feet are washed with water and used.
  • Mulberry root bark, brier roots, organo trees, ganoderma lucidum and cactus are washed thoroughly and dried for 1 to 2 days in the shade, and then dried for 30 days at 30 to 45 °C.
  • Water is used to immerse all raw materials, and is usually used in 500 to 5000 parts by weight based on 100 parts by weight of chicken feet.
  • the heating is carried out so that only the chicken feet remain bone, specifically for 7 to 15 hours at 80-100 °C. If the temperature and time are less than the above range, it is not possible to sufficiently extract useful ingredients from each material. On the contrary, if the temperature and time exceed the above range, there is a risk of deoxidation.
  • the pressure may be applied by using a high pressure vessel.
  • Filtration removes debris from chicken foot bones, mulberry root bark, brier roots, cucumber trees, ganoderma lucidum and cacti.
  • Filtration can be performed using a conventional filtration apparatus such as a sieve, and is not particularly limited in the present invention.
  • the heating is performed by dividing, and in the second heating process, the heating time is relatively short, and the active ingredient is extracted by heating the cheonggung, Angelica, licorice and jujube.
  • Cheongung, Angelica, and Jujube are washed thoroughly and dried for 1 to 2 days in the shade, and then dried for 2 to 3 days at 30 to 45 ° C.
  • the second heating process is carried out until each raw material is loosened and all released, and is performed for 4 to 10 hours at 80-100 °C. If the temperature and time are less than the above range, it is not possible to sufficiently extract useful ingredients from each material. On the contrary, if the temperature and time exceed the above range, there is a risk of deoxidation.
  • the filtration is performed in the same manner as in the first filtration process, and only the filtrate is collected without discarding the dregs due to cheonggung, donkey, licorice and jujube.
  • the filtrate obtained through these steps is applied as a dietary supplement to alleviate and improve the symptoms of joint diseases.
  • the filtrate may be formulated into a pill, granule, tablet, powder, or capsule form by drinking or drying after it is powdered.
  • the ring is dried after the filtrate is powdered, and recirculated by adding flour, wheat paste, syrup or honey.
  • the manufacture of the ring may be performed by using a refiller or by hand.
  • the granules prepared may be extruded in appropriate amounts to form tablets or powders, or filled into capsules to produce capsules.
  • various food additives used in the dietary supplement may be added.
  • sugars such as monosaccharides, disaccharides, polysaccharides and sugar alcohols, flavours such as taumartin, stevia extract, saccharin and aspartame, nutrients, vitamins, edible electrolytes, flavors, coloring agents, pectic acid, Alginic acid, organic acid, protective colloidal thickeners, pH adjusters, stabilizers, preservatives, glycerin, carbonating agents and the like can be used.
  • Such food additives may be used within 5% by weight in the total composition.
  • the various types of dietary supplements prepared by the method as described above may be individually packaged by an appropriate single dose or may be packaged in a container.
  • the dosage may vary depending on the dosage form.
  • the filtrate is ingested as it is, it can be pouched into 100-150 ml, and can be taken one bag each morning and evening twice a day.
  • the dosage form depends on the type of dietary supplement, and can be modified depending on the condition and weight of the user, the degree, form and duration of the disease.
  • various symptoms of joint disease may be alleviated or improved.
  • Joint diseases such as arthritis are accompanied by inflammation and pain.
  • the cartilage that is responsible for the buffer between bones wears thinner, causing friction between bones, causing inflammation and pain.
  • a lot of lubricating fluid is secreted from the body as a compensating action to solve this, and this causes the joint to swell.
  • the health supplement according to the present invention provides nutrition to the bones and joints, the surrounding muscles and ligaments, restores damaged soft tissues, promotes blood circulation around the joints and improves the joint environment.
  • by providing abundant nourishment to the bones and joints not only stops the aging of the joints, but also helps to maintain the joints themselves.
  • the filtrate was put into a heating container after the filtrate was filtered using a sieve.
  • a liquid product was prepared in the same manner as in Example 1 except that no chicken feet were used.
  • a liquid product was prepared in the same manner as in Example 1, except that the millennial herb was not used.
  • the present study was carried out by dividing 21 subjects with chronic knee arthritis (age 40-75 years) into three groups: group 1 (Example 1), group 2 (Comparative Example 1) and group 3 (Comparative Example 2).
  • the liquid products prepared in Examples 1 and 2 and Comparative Examples 1 and 2 were to be taken 1 bag each morning and evening for 3 months. After one month of ingestion, two months later, three months later, the degree of joint disease improvement of the test subjects was checked through a questionnaire, and the score was given based on the following criteria for swelling, pain, and stiffness of the knee, and the average value thereof was calculated by the following Table 1 Shown in
  • Example 1 Referring to Table 1, it can be seen that most of the test subjects who consumed the liquid product of Example 1 greatly relieved swelling and pain due to knee arthritis. In addition, it can be seen indirectly that the articular cartilage is being regenerated due to the lack of stiffness and the feeling of flexibility. At this time, there were no side effects in all patients who participated in the clinical trial.
  • Health supplements according to the present invention can be mass-produced and marketed to promote national health.

Abstract

La présente invention concerne un complément alimentaire de santé pour maintenir une santé articulaire et atténuer des symptômes d'arthrite, et son procédé de préparation, et plus spécifiquement : un complément alimentaire de santé préparé en utilisant, comme matières premières, des pieds de poulet, le cactus, l'écorce de racine de mûrier, la racine de Rosa multiflora, l'Acanthopanax sessiliflorus, le Ganoderma lucidum, le Cnidii Rhizoma, le Angelica gigas Nakai, le Glycyrrhizia uralensis et le jujube ; et son procédé de préparation. Étant donné que le complément alimentaire de santé est réalisé à partir d'ingrédients naturels uniquement, le complément alimentaire de santé est absorbé rapidement dans le corps, en ayant ainsi des effets réparant des cartilages endommagés de manière à favoriser l'élasticité de cartilage, inhibant ou traitant une inflammation, réduisant une inflammation intra-articulaire et un œdème, et soulageant des symptômes de maladie arthritique.
PCT/KR2016/002434 2015-04-08 2016-03-11 Complément alimentaire de santé pour atténuer des symptômes de maladie articulaire, et son procédé de préparation WO2016163649A1 (fr)

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KR10-2015-0049757 2015-04-08
KR1020150049757A KR101578068B1 (ko) 2015-04-08 2015-04-08 관절 질환 증상 완화용 건강보조식품 및 이의 제조방법

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KR101962894B1 (ko) * 2017-09-05 2019-07-31 서울대학교산학협력단 천연물 복합오일을 포함하는 통증완화 조성물
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