WO2016121761A1 - Dispersion, son procédé de préparation et produit cosmétique - Google Patents

Dispersion, son procédé de préparation et produit cosmétique Download PDF

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Publication number
WO2016121761A1
WO2016121761A1 PCT/JP2016/052199 JP2016052199W WO2016121761A1 WO 2016121761 A1 WO2016121761 A1 WO 2016121761A1 JP 2016052199 W JP2016052199 W JP 2016052199W WO 2016121761 A1 WO2016121761 A1 WO 2016121761A1
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Prior art keywords
dispersion
oxide particles
inorganic oxide
weight
oil
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PCT/JP2016/052199
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English (en)
Japanese (ja)
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佐野晃文
小野啓治
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堺化学工業株式会社
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Publication of WO2016121761A1 publication Critical patent/WO2016121761A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/06—Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/28—Zirconium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/365—Hydroxycarboxylic acids; Ketocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/89—Polysiloxanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/12—Face or body powders for grooming, adorning or absorbing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations

Definitions

  • the present invention provides a high-concentration dispersion of inorganic oxide particles that does not settle easily and has high storage stability.
  • the dispersion obtained in the present invention is particularly useful in the field of cosmetics such as sunscreen and foundation, and can be used as a raw material thereof.
  • inorganic oxide particles such as zinc oxide, iron oxide, cerium oxide, zirconium oxide, and bismuth oxide are mainly used as UV protection agents in the cosmetics field.
  • Such inorganic oxide particles are sold, stored and transported as a dispersion in which the particles are dispersed in an oily medium in order to prevent aggregation and facilitate uniform mixing with other components.
  • the inorganic oxide particles can be blended at a high concentration in the dispersion, it is preferable in that the influence on the prescription of the components contained in the oil phase can be reduced and the cost of storage, transportation, storage and the like can be reduced.
  • sunscreens are generally prescribed in an emulsifying system, and there are mainly two types of emulsions, an oil-in-water type and a water-in-oil type.
  • an oil-in-water type In order to give a refreshing feel to the oil-in-water emulsion among them, a formulation with a relatively small amount of oil may be formulated.
  • inorganic oxide particles for sunscreen when using inorganic oxide particles for sunscreen as an ultraviolet shielding agent, it is generally mixed in oil. In order to obtain sufficient ultraviolet shielding performance, it is desirable to increase the blending amount of the inorganic oxide. However, it is difficult to mix a large amount of inorganic oxide particles in the oil phase in a system with little oil because there are few dispersion media.
  • Patent Documents 1 and 2 disclose a dispersion in which powder is dispersed in oil in advance and used as a raw material for sunscreen and cosmetics.
  • a dispersion using ester oil or silicone oil as a dispersion medium is proposed.
  • Cited Document 1 only describes a dispersion using titanium oxide particles, and does not describe other inorganic oxide particles.
  • the oil agent or dispersant described in the cited document 2 it is difficult to produce a dispersion having a pigment concentration exceeding 50.0% by mass, and the dispersion may be gelled.
  • Patent Document 3 proposes a high-concentration zinc oxide dispersion using volatile isoparaffin as a dispersion medium.
  • volatile oils are often used from the viewpoint of compatibility with other organic substances, and the system may become unstable if cyclopentasiloxane or volatile isoparaffin is used. there were.
  • Patent Document 4 proposes a self-dispersing metal oxide coated with a dispersant, and in the examples, titanium oxide surface-coated with triethoxysilane and polyhydroxystearic acid is disclosed.
  • this invention relates to a powder excellent in self-dispersibility, and does not consider storage stability, which is a major factor in using the dispersion as a raw material for sunscreen and the like.
  • An object of the present invention is to solve the above-mentioned problems, and to provide a dispersion which is a raw material for cosmetics which contains inorganic oxide particles at a high concentration and is excellent in storage stability.
  • the present invention is a dispersion in which inorganic oxide particles are dispersed in an oil-based medium, and contains an ester oil having 18 or more carbon atoms and polyhydroxystearic acid.
  • the inorganic oxide particles include zinc oxide and iron oxide. And at least one selected from the group consisting of cerium oxide, zirconium oxide and bismuth oxide, and the amount of polyhydroxystearic acid is 0.5 to 8.0% by weight with respect to the total weight of the dispersion.
  • the dispersion is characterized in that the compounding amount of the components is 10.0% by weight or less with respect to the total weight of the dispersion, and the inorganic oxide particles are 51.0% by weight or more of the whole dispersion.
  • the dispersion preferably has a sedimentation rate of 1.0% by weight or less when allowed to stand at 50 ° C. for 60 days.
  • the dispersion preferably has a viscosity at 20 ° C. immediately after dispersion of 6000 mPa ⁇ s or less and a viscosity at 20 ° C. after standing at 50 ° C. for 60 days is 6000 mPa ⁇ s or less.
  • the inorganic oxide particles preferably have an average primary particle diameter of 100 nm or less and have an ultraviolet shielding effect.
  • the inorganic oxide particles are preferably those whose inorganic surface is coated with a hydroxide and / or oxide of an element selected from silicon, aluminum, zinc, iron, titanium and zirconium.
  • the inorganic oxide particles are preferably those whose organic surface is coated with an organosilicon compound.
  • the inorganic oxide particles are preferably surface-coated with hydrous silica and / or organopolysiloxane.
  • the present invention is also a method for producing a dispersion as described above, which comprises the steps of mixing, stirring and dispersing inorganic oxide particles, ester oil having 18 or more carbon atoms and polyhydroxystearic acid.
  • the present invention is also a cosmetic obtained by blending the above dispersion.
  • the cosmetic is preferably an oil-in-water emulsified cosmetic.
  • the dispersion of the present invention is excellent in storage stability while blending inorganic oxide particles at a high ratio of 51.0% by weight or more with respect to the total weight of the dispersion. Thereby, when blending inorganic oxide particles in cosmetics, it can be suitably used as a raw material for obtaining cosmetics of various formulations without affecting the formulation.
  • the dispersion of the present invention is a dispersion in which inorganic oxide particles are blended at a high blending ratio of 51.0% by weight or more based on the total weight of the dispersion.
  • the range of the amount of the inorganic oxide particles is not limited, but the upper limit is preferably 80.0% by weight, and more preferably 75.0% by weight. Further, the lower limit is more preferably 55.0% by weight, still more preferably 61.0% by weight.
  • the inorganic oxide particles blended in the dispersion of the present invention is at least one selected from the group consisting of zinc oxide, iron oxide, cerium oxide, zirconium oxide and bismuth oxide. Among these, it is most preferable to use zinc oxide.
  • the inorganic oxide particles used in the present invention are not particularly limited, and general particles used in the cosmetic field can be used.
  • the inorganic oxide particles preferably have an average particle size of 100 nm or less. Inorganic oxide particles having such a particle diameter are particularly preferable in that they have high visible light transparency and a suitable ultraviolet shielding region.
  • the lower limit of the average particle diameter is not particularly limited, but is preferably 10 nm or more. When the thickness exceeds 100 nm, not only the visible light transparency is deteriorated but also the ultraviolet shielding ability may be lowered.
  • the particle size of the inorganic powder was measured by a method of measuring the particle size of 200 particles randomly selected with a transmission electron microscope and calculating the average of the primary particle sizes.
  • the upper limit of the average particle diameter is more preferably 80 nm, and further preferably 65 nm.
  • the lower limit of the average particle diameter is more preferably 15 nm.
  • the shape of the inorganic oxide particles is not particularly limited, and any shape such as a spherical shape, a rod shape, a needle shape, a spindle shape, or a plate shape can be used.
  • the average particle diameter is defined by the length on the short axis side, and in the case of a plate-like particle, the average of the diagonal lengths of the surfaces.
  • the inorganic oxide particles of the present invention preferably have an ultraviolet shielding effect. That is, this is because the present invention is characterized in that inorganic oxide particles having an ultraviolet shielding effect are efficiently blended in cosmetics.
  • “having an ultraviolet shielding effect” means 365 nm when a coating film obtained by applying a PWC (pigment weight concentration) 50% or more paste with a 25 ⁇ m thick applicator is measured with a spectrophotometer (manufactured by JASCO Corporation). This means that the transmittance is 30% or less.
  • the inorganic oxide particles may have an organic surface coating formed with an organosilicon compound.
  • the inorganic surface coating may be performed with a hydroxide and / or oxide of at least one element selected from silicon, aluminum, zinc, iron, titanium and zirconium. Further, both the inorganic surface coating and the organic surface coating may be formed, or only the organic surface coating may be used. By forming such a layer, the stability of the dispersion can be further improved by the action of imparting water repellency to the powder and enhancing the lipophilicity.
  • the organic surface coating is formed of a known silicone having a hydrogen-silicon bond, such as methyl hydrogen polysiloxane (dimethicone / methicone) copolymer, or triethoxysilylethyl polydimethylsiloxyethyl dimethicone having an alkoxy group-silicon bond as a reactive group (Shin-Etsu). It may be one that has been treated with a known organosilicon compound such as KF-9908) manufactured by Kagaku Kogyo, or triethoxysilylethyl polydimethylsiloxyethylhexyl dimethicone (KF-9909 manufactured by Shin-Etsu Chemical Co., Ltd.).
  • a known silicone having a hydrogen-silicon bond such as methyl hydrogen polysiloxane (dimethicone / methicone) copolymer, or triethoxysilylethyl polydimethylsiloxyethyl dimethi
  • the surface treatment method using the organosilicon compound is not particularly limited, and can be performed by a known method such as dry treatment or wet treatment.
  • the organic surface coating is preferably 0.1 to 20.0% by weight based on the weight of the inorganic oxide particles after the surface coating. If it is less than 0.1% by weight, the effect of improving the functionality due to the surface treatment is not manifested. Specifically, it is not preferable in that water repellency and lipophilicity cannot be obtained. It is not preferable in that the powder is agglomerated by a simple treatment agent and the original ultraviolet shielding effect may not be exhibited, and it is not economical.
  • the lower limit of the coating amount of the surface coating is more preferably 0.5% by weight, still more preferably 1.0% by weight.
  • the upper limit of the coating amount of the surface coating is more preferably 18.0% by weight, still more preferably 15.0% by weight.
  • the inorganic surface coating is made of a hydroxide and / or oxide of at least one element selected from silicon, aluminum, zinc, iron and zirconium. By carrying out the inorganic surface coating, it is preferable in that the dispersion is more stable due to the action of suppressing the surface activity of the inorganic oxide particles or improving the lipophilicity with the oil agent. .
  • the inorganic surface coating may be applied to the inner layer of the organic surface coating or may be applied to the outer layer of the organic surface coating. However, in terms of the effect of improving dispersibility, It is preferably applied to the inner layer of the organic surface coating.
  • Inorganic surface coating with a hydroxide and / or oxide of at least one element selected from silicon, aluminum, zinc, iron and zirconium can suppress the surface activity of the inorganic oxide particles by applying these coatings. This is preferable. Moreover, what carried out inorganic surface coating
  • Method a method in which inorganic oxide particles are dispersed in water to form a water slurry, and a surface treatment agent is added to the water slurry, followed by neutralization, water washing, drying, and pulverization steps.
  • the method of thermally decomposing a surface treating agent by baking after adding can be mentioned.
  • Other examples include sulfates, nitrates, and chlorides of the above elements.
  • the inorganic surface coating is preferably 0.1 to 30.0% by weight based on the weight of the inorganic oxide particles after the surface coating. If it is less than 0.1% by weight, it is not preferable in that the effect of improving the functionality due to the surface treatment is not manifested. In addition, the surface treatment is unfavorable in that the powder feel is poor, the cosmetic may be smeared when applied to the skin, and is not economical.
  • the lower limit of the coating amount of the surface coating is more preferably 0.5% by weight, still more preferably 2% by weight.
  • the upper limit of the coating amount of the surface coating is more preferably 28.0% by weight, and further preferably 22.0% by weight.
  • the surface treatment is most preferably composed of a first coating layer formed of hydrous silica and a second coating layer formed of organopolysiloxane formed on the first coating layer. . That is, the inorganic oxide particles subjected to such surface treatment are preferable in that a dispersion having excellent stability when a dispersion is produced at a high concentration can be obtained.
  • examples of inorganic oxide particles include FINEX-30W-LP2, FINEX-33W-LP2, FINEX-33W-LPF1, FINEX-50W-LP2, FINEX-52W-LP2, FINEX, which are hydrophobized zinc oxides manufactured by Sakai Chemical Industry Co., Ltd. -50W-LPF1 (all are trade names).
  • the dispersion of the present invention contains an ester oil having 18 or more carbon atoms. That is, it contains a specific ester oil as a liquid medium. By using such an ester oil, it is preferable in that the irritation of the ester oil can be suppressed, and the influence on the human body when made into a cosmetic can be reduced.
  • the ester oil having 18 or more carbon atoms is a liquid compound having an ester group, and the number of carbon atoms in one molecule exceeds 18.
  • the ester oil having 18 or more carbon atoms is preferably blended at a ratio of 25.0 to 48.5% by weight. That is, it is preferably used as a main component in a liquid medium.
  • an oil medium other than the ester oil having 18 or more carbon atoms may be blended.
  • the oil medium other than the ester oil having 18 or more carbon atoms is blended.
  • the amount is preferably 25.0% by weight or less based on the total weight of the dispersion. That is, by using an ester oil having 18 or more carbon atoms as a liquid medium, the above-described effects can be obtained. However, when other oil-based medium is used exceeding 25.0% by weight, the above-described properties are obtained. This is because there is a risk of getting worse.
  • the blending amount of the oily medium other than the ester oil having 18 or more carbon atoms is more preferably less than 20.0% by weight.
  • the blending amount of the silicone component needs to be 10.0% by weight or less with respect to the total weight of the dispersion.
  • the blending amount of the silicone component is more preferably 5.0% by weight or less.
  • Silicone components are likely to have an adverse effect on the stability of the oil dispersion of inorganic oxide particles, and moreover to the stability of oil-in-water emulsion cosmetics. Is preferred.
  • the silicone-based component refers to a liquid component containing silicon in the structure, such as silicone oil and silicone-based dispersant contained in the liquid medium.
  • the dispersion of the present invention contains polyhydroxystearic acid. That is, a dispersion is obtained using polyhydroxystearic acid as a dispersant. By using such a dispersant, an excellent effect can be obtained in that the inorganic oxide particles can be uniformly dispersed in the oily medium.
  • the polyhydroxystearic acid is an oligomerized compound formed by forming an ester bond with hydroxystearic acid, and commercially available products include Saracos HS-6C (Nisshin Oilio Co., Ltd.), Solsperse 21000 (Nippon Lubrizol). Etc.) are sold, and these can be used.
  • the degree of polymerization of the polyhydroxystearic acid is not particularly limited, but is preferably 4 to 8.
  • the polyhydroxystearic acid is 0.5 to 8.0% by weight based on the total weight of the dispersion. If the amount is less than 0.5% by weight, there is a problem that the dispersion effect is insufficient and the dispersion tends to increase in viscosity. If the amount exceeds 8.0% by weight, the touch is adversely affected when blended in cosmetics. Cause problems.
  • the lower limit is more preferably 0.7% by weight, and more preferably 1.0% by weight.
  • the upper limit is more preferably 6.0% by weight, and more preferably 4.0% by weight.
  • the dispersion of the present invention may contain other dispersants in addition to polyhydroxystearic acid as long as the effects of the present invention are not impaired.
  • the blending amount of the dispersant other than polyhydroxystearic acid is preferably less than 6.0% by weight with respect to the total weight of the dispersion together with polyhydroxystearic acid.
  • a silicone-based dispersant may cause a decrease in dispersion stability, it is preferable to reduce the amount of use thereof.
  • the blending amount of the silicone-based dispersant is preferably less than 8.0% by weight with respect to the total weight of the dispersion.
  • the dispersion of this invention may mix
  • the blending amount of the components other than those described above is preferably 3.0% by weight or less with respect to the entire dispersion.
  • the dispersion of the present invention preferably has a sedimentation rate of 1% by weight or less when allowed to stand at 50 ° C. for 60 days. That is, by making such a stable dispersion state having a low sedimentation rate maintained for a long period of time, it is suitable for long-term storage, transportation, etc., and is preferable in terms of distribution.
  • the measuring method of the said sedimentation rate is measured by the method described in detail in the Example.
  • the dispersion of the present invention preferably has a viscosity at 20 ° C. immediately after dispersion of 6000 mPa ⁇ s or less and a viscosity at 20 ° C. after standing at 50 ° C. for 60 days is 6000 mPa ⁇ s or less. That is, it is preferable that it has a relatively low viscosity and does not cause a problem that the viscosity increases when stored for a long period of time.
  • the dispersion obtained by the formulation as described above basically satisfies such parameters. Thereby, it can be set as the dispersion which can be used stably as a cosmetics raw material. Note that “immediately after dispersion” means within 24 hours of standing at room temperature after the dispersion treatment.
  • the method for producing the dispersion of the present invention is not particularly limited, and can be obtained by mixing and dispersing the above-described raw materials by a known method.
  • a method for producing such a dispersion is also one aspect of the present invention.
  • As a method for dispersing the surface hydrophobized inorganic oxide in the oily medium as described above for example, polyhydroxystearic acid is dissolved in ester oil, and the surface hydrophobized inorganic oxide is added thereto to strengthen the surface. What is necessary is just to disperse
  • the dispersion treatment can be performed, for example, by a paint shaker treatment or bead mill treatment using zirconia beads having a diameter of 0.3 mm or less for the medium.
  • the effect of the present invention is not sufficiently exhibited when it is prepared with a normal emulsifying disperser such as a disper or a homomixer.
  • a normal emulsifying disperser such as a disper or a homomixer.
  • a disper or a homomixer There are horizontal types and vertical types of bead mills, but either type may be used.
  • a dispersion having better storage stability can be obtained when the temperature of the dispersion during dispersion is lower. For example, it is preferable to disperse so that the temperature of the dispersion is 10 ° C. to 40 ° C. If the dispersion time is too long, the coating layer of the surface-coated particles may be peeled off, thereby affecting the stability of the dispersion.
  • the dispersion of the present invention can be suitably used as a raw material for blending cosmetics.
  • Cosmetics to which the dispersion of the present invention can be blended are not particularly limited, and any form such as oil-in-water emulsified cosmetics, water-in-oil emulsified cosmetics, oil-based oily cosmetics, etc. Can be mentioned. Especially, it can use especially suitably also in cosmetics with comparatively few oil-based components among oil-in-water type cosmetics.
  • a relatively large amount of inorganic oxide particles are blended even in cosmetics with a small amount of oily components, so that it has high UV protection performance. It can be.
  • the oil component is 66.0% by weight or less of the entire cosmetic
  • the manufacturing method of the said cosmetics is not specifically limited, It can manufacture according to a well-known arbitrary method.
  • the cosmetic may be used in combination with any aqueous component or oily component that can be used in the cosmetic field.
  • the aqueous component and the oil component are not particularly limited, and examples thereof include oil agents, surfactants, humectants, higher alcohols, sequestering agents, natural and synthetic polymers, water-soluble and oil-soluble polymers, UV shielding agents, Various extracts, colorants such as organic dyes, preservatives, antioxidants, pigments, thickeners, pH adjusters, fragrances, cooling agents, antiperspirants, bactericides, skin activators, other drugs, various powders It may contain components such as body.
  • the oil agent is not particularly limited.
  • natural animal and vegetable oils and fats for example, olive oil, mink oil, castor oil, palm oil, beef tallow, evening primrose oil, coconut oil, cacao oil, macadamia nut oil and the like
  • wax for example, jojoba oil
  • Higher alcohols eg lauryl alcohol, stearyl alcohol, cetyl alcohol, oleyl alcohol
  • higher fatty acids eg lauric acid, palmitic acid, stearic acid, oleic acid, behenine
  • higher aliphatic hydrocarbons such as liquid paraffin, solid paraffin, squalane, petrolatum, ceresin, microcrystalline wax, etc .
  • silicone derivatives eg, silicone oils such as methyl silicone and methyl phenyl silicone
  • oil-soluble vitamins, preservatives, whitening agents, and the like can be added.
  • the surfactant examples include a lipophilic nonionic surfactant and a hydrophilic nonionic surfactant.
  • the lipophilic nonionic surfactant is not particularly limited. For example, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate.
  • sorbitan fatty acid esters such as diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, glyceryl monostearate, ⁇ , ⁇ '-Glycerol polyglycerin fatty acids such as pyroglutamate glyceryl oleate, glyceryl monostearate malate, propylene glycol monostearate Glycol fatty acid esters, hardened castor oil derivatives, glycerin alkyl ethers and the like.
  • sorbitan fatty acid esters such as diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate, mono-cotton
  • the hydrophilic nonionic surfactant is not particularly limited.
  • POE sorbitan fatty acid esters such as POE sorbitan monooleate, POE sorbitan monostearate, POE sorbitan tetraoleate, POE sorbite monolaurate, and POE sorbite mono POE sorbite fatty acid esters such as oleate, POE sorbite pentaoleate, POE sorbite monostearate, POE glycerin fatty acid esters such as POE glycerol monostearate, POE glycerol monoisostearate, POE glycerol triisostearate, POE POE fatty acid esters such as monooleate, POE distearate, POE monodiolate, ethylene glycol stearate, POE lauryl ether, POE POE alkyl ethers such as yl ether, POE stearyl ether,
  • surfactants examples include anionic surfactants such as fatty acid soaps, higher alkyl sulfates, POE lauryl sulfate triethanolamine, alkyl ether sulfates, alkyltrimethylammonium salts, alkylpyridinium salts, alkyl quaternary salts. Stability and skin irritation of cationic surfactants such as ammonium salts, alkyldimethylbenzylammonium salts, alkylamine salts, polyamine fatty acid derivatives, and amphoteric surfactants such as imidazoline amphoteric surfactants and betaine surfactants You may mix
  • anionic surfactants such as fatty acid soaps, higher alkyl sulfates, POE lauryl sulfate triethanolamine, alkyl ether sulfates, alkyltrimethylammonium salts, alkylpyridinium salts, alkyl quaternary salts
  • the humectant is not particularly limited, and examples thereof include xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, sodium lactate, bile salt, dl- Examples include pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO) PO adduct, Isaiyobara extract, yarrow extract, and merirot extract.
  • EO diglycerin
  • the higher alcohol is not particularly limited, and examples thereof include linear alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, monostearyl glycerin ether (batyl alcohol), 2-decyl.
  • linear alcohols such as lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, monostearyl glycerin ether (batyl alcohol), 2-decyl.
  • branched chain alcohols such as tetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyldodecanol, isostearyl alcohol, octyldodecanol, and the like.
  • the sequestering agent is not particularly limited.
  • examples thereof include sodium, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid and the like.
  • the natural water-soluble polymer is not particularly limited.
  • the semi-synthetic water-soluble polymer is not particularly limited.
  • starch-based polymers such as carboxymethyl starch and methylhydroxypropyl starch, methylcellulose, nitrocellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, Examples thereof include cellulose polymers such as hydroxypropylcellulose, sodium carboxymethylcellulose (CMC), crystalline cellulose, and cellulose powder, and alginic acid polymers such as sodium alginate and propylene glycol alginate.
  • CMC carboxymethylcellulose
  • crystalline cellulose cellulose powder
  • alginic acid polymers such as sodium alginate and propylene glycol alginate.
  • the synthetic water-soluble polymer is not particularly limited, and examples thereof include vinyl polymers such as polyvinyl alcohol, polyvinyl methyl ether, and polyvinyl pyrrolidone, and polyoxyethylene polymers such as polyethylene glycol 20,000, 40,000, and 60,000.
  • Polymer polyoxyethylene polyoxypropylene copolymer copolymer polymer, acrylic polymer such as sodium polyacrylate, polyethyl acrylate, polyacrylamide, polyglycerin, polyethyleneimine, cationic polymer, carboxyvinyl polymer, alkyl Modified carboxyvinyl polymer, (hydroxyethyl acrylate / acryloyl dimethyl taurine Na) copolymer, (Na acrylate / acryloyl dimethyl taurine Na) copolymer, (acryloyl dimethyl tantalum) Phosphorus ammonium / vinylpyrrolidone) copolymer, and (ammonium acryloyldimethyltaurate methacrylate Beheneth-25) cross-polymer.
  • acrylic polymer such as sodium polyacrylate, polyethyl acrylate, polyacrylamide, polyglycerin, polyethyleneimine, cationic polymer, carboxyvinyl polymer, alkyl Modified carboxy
  • the inorganic water-soluble polymer is not particularly limited, and examples thereof include bentonite, silicate AlMg (beegum), laponite, hectorite, and silicic anhydride.
  • the UV screening agent is not particularly limited.
  • paraaminobenzoic acid hereinafter abbreviated as PABA
  • PABA paraaminobenzoic acid
  • PABA monoglycerin ester N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester, N, N-dimethyl
  • Benzoic acid UV screening agents such as PABA ethyl ester and N, N-dimethyl PABA butyl ester
  • Anthranilic acid UV screening agents such as homomenthyl-N-acetylanthranylate
  • Amyl salicylate Menthyl salicylate, Homomentil salicylate, Octyl salicylate
  • Salicylic acid UV screening agents such as phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate; octylcinnamate, ethyl-4-isoprop
  • Other drug components are not particularly limited and include, for example, vitamin A oil, retinol, retinol palmitate, inosit, pyridoxine hydrochloride, benzyl nicotinate, nicotinamide, nicotinic acid DL- ⁇ -tocopherol, magnesium ascorbate phosphate, 2 Vitamins such as -O- ⁇ -D-glucopyranosyl-L-ascorbic acid, vitamin D2 (ergocaciferol), dl- ⁇ -tocopherol, dl- ⁇ -tocopherol acetate, pantothenic acid, biotin; estradiol, ethinylestradiol, etc.
  • Hormones such as arginine, aspartic acid, cystine, cysteine, methionine, serine, leucine and tryptophan; anti-inflammatory agents such as allantoin and azulene; whitening agents such as arbutin; astringents such as tannic acid; L Menthol, cooling agents and sulfur camphor such as, lysozyme chloride, can be mentioned pyridoxine chloride, and the like.
  • Examples of the various powders include bengara, yellow iron oxide, black iron oxide, titanium mica, iron oxide-coated mica titanium, titanium oxide-coated glass flakes and other bright colored pigments, mica, talc, kaolin, sericite, titanium dioxide,
  • examples thereof include inorganic powders such as silica and organic powders such as polyethylene powder, nylon powder, crosslinked polystyrene, cellulose powder, and silicone powder.
  • a part or all of the powder component is hydrophobized by a known method with a substance such as silicones, fluorine compounds, metal soaps, oils, acyl glutamates in order to improve sensory characteristics and cosmetic durability. Used. Moreover, you may mix and use the other composite powder which does not correspond to this invention.
  • Example 1 Hydrophobized zinc oxide (FINEX-33W-LP2, manufactured by Sakai Chemical Industry Co., Ltd., primary particle diameter of 35 nm by observation with a transmission electron microscope, zinc oxide surface treated with hydrous silica and organopolysiloxane) 70.0 parts Weighing 28.5 parts of ethylhexyl palmitate (PALMESTER 1543, PalmOleo (Klang) Sdn. The mixture was mixed in a mayonnaise bottle with 100.0 parts of ⁇ 0.3 mm zirconia beads and then treated with a paint shaker (manufactured by Red Devil) for 1 hour to obtain a zinc oxide dispersion after bead separation.
  • PALMESTER 1543 ethylhexyl palmitate
  • Example 2 Hydrophobized zinc oxide (FINEX-33W-LP2, manufactured by Sakai Chemical Industry Co., Ltd., primary particle diameter of 35 nm by observation with a transmission electron microscope, zinc oxide surface treated with hydrous silica and organopolysiloxane) 70.0 parts , 28.5 parts of isotridecyl isononanoate (Saracos 913, manufactured by Nisshin Oilio, carbon number 22), 1.5 parts of polyhydroxystearic acid (Saracos HS-6C, manufactured by Nisshin Oilio), and ⁇ 0.3 mm zirconia beads After mixing with 100.0 parts in a mayonnaise bottle, the mixture was treated with a paint shaker (manufactured by Red Devil) for 1 hour to obtain a zinc oxide dispersion after bead separation.
  • a paint shaker manufactured by Red Devil
  • Example 3 Hydrophobized zinc oxide (FINEX-33W-LP2, manufactured by Sakai Chemical Industry Co., Ltd., primary particle diameter 35 nm by observation with a transmission electron microscope, zinc oxide surface treated with hydrous silica and organopolysiloxane) 60.0 parts Weighing 3 parts of ethylhexyl palmitate (PALMESTER 1543, PalmOleo (Klang) Sdn. The mixture was mixed in a mayonnaise bottle with 100.0 parts of ⁇ 0.3 mm zirconia beads and then treated with a paint shaker (manufactured by Red Devil) for 1 hour to obtain a zinc oxide dispersion after bead separation.
  • PALMESTER 1543 ethylhexyl palmitate
  • Example 4 Hydrophobized zinc oxide (FINEX-30S-LPT, manufactured by Sakai Chemical Industry Co., Ltd., primary particle size measured by transmission electron microscope 35 nm, zinc oxide surface treated with organopolysiloxane) 65.0 parts, isononanoic acid Isotridecyl (Saracos 913, manufactured by Nisshin Oilio, carbon number 22) 33.0 parts, polyhydroxystearic acid (Saracos HS-6C, manufactured by Nisshin Oilio Co., Ltd.) 2.0 parts was weighed and ⁇ 0.3 mm zirconia beads 100.0 After mixing with a part in a mayonnaise bottle, the mixture was treated with a paint shaker (manufactured by Red Devil) for 1 hour to obtain a zinc oxide dispersion after bead separation.
  • a paint shaker manufactured by Red Devil
  • Example 5 The raw materials were weighed under the conditions of Example 1, stirred and mixed, and then treated in a bead mill using zirconia beads having a diameter of ⁇ 0.3 mm as a medium for 6 hours. After the beads were separated, a zinc oxide dispersion was obtained.
  • Example 6 The raw materials were weighed under the conditions of Example 2, mixed with stirring, and then treated in a bead mill using zirconia beads having a diameter of ⁇ 0.3 mm as a medium for 6 hours. After separation of the beads, a zinc oxide dispersion was obtained.
  • Example 7 The raw materials were weighed under the conditions of Example 4, mixed with stirring, and then treated for 6 hours in a bead mill using zirconia beads having a diameter of 0.3 mm as a medium. After the beads were separated, a zinc oxide dispersion was obtained.
  • the dispersions obtained by the examples and comparative examples described above were evaluated under the following conditions. [viscosity] The dispersion was put into a 50 ml screw bottle, and a rotor No. 3 and the viscosity after 60 seconds was measured. The dispersion viscosity data after dispersion is shown in Table 1.
  • compositions of the dispersions of the above Examples and Comparative Examples are summarized in Table 1.
  • the loss on drying refers to the weight loss rate after heating for 40 minutes at 120 ° C. when using an infrared moisture meter (FD-610: manufactured by Kett Scientific Laboratory).
  • FD-610 manufactured by Kett Scientific Laboratory
  • the supernatant of the dispersion stored in a 50 ml screw bottle was collected and evaluated.
  • the sedimentation rate is calculated from the ignition loss value of the dispersion supernatant.
  • the ignition loss value of the dispersion immediately after dispersion is X 0
  • the ignition loss value of the dispersion supernatant after standing at 50 ° C. dryer for 30 days is X 1
  • the ignition loss value and X 2 was calculated following 50 ° C. dryer 30 days from the formula standing settling rate Y 1 and 50 ° C. dryer 60 days standing settling rate Y 2.
  • Y 1 100 ⁇ X 1 / X 0 ⁇
  • Y 2 100 ⁇ X 2 / X 0 ⁇ 100
  • the dispersion of the present invention has excellent storage stability and has excellent properties that hardly generate sediment even after long-term storage.
  • Examples 8 and 9 A cosmetic material having the composition shown in Table 4 was prepared by the following production method, and each sample was evaluated for stability over time (stability of the cosmetic material). The results are also shown in Table 4. In addition, the numerical value in Table 4 represents a weight part.
  • Example 7 * 1 Dispersion obtained in Example 7 * 2: GT-10W (manufactured by Sakai Chemical Industry Co., Ltd.) Hydrophilized titanium oxide (STR-100W, manufactured by Sakai Chemical Industry, whose primary particle diameter is 10 nm by transmission electron microscope observation and whose surface is treated with hydrous silica) 40.0% by weight, purified water 46. 0 wt%, 1,3-butylene glycol 10.0 wt%, and 1,2-pentanediol 4.0 wt% were added for 1 hr. After mixing and dispersing with a bead mill. * 3: Toray Dow Corning * 4: SEPPIC
  • the dispersion of the present invention can be used for blending inorganic oxide particles in various cosmetics.

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  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
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  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)

Abstract

[Problème] Obtenir une dispersion qui mélange des particules d'oxyde inorganiques à concentrations élevées et présente une excellente stabilité de conservation. [Solution] La présente invention concerne une dispersion comprenant des particules d'oxyde inorganiques dispersées dans un milieu à base d'huile et contenant une huile d'ester C18 ou supérieure et un acide polyhydroxystéarique. Les particules d'oxyde inorganiques sont au moins un type choisi dans le groupe constitué par l'oxyde de zinc, l'oxyde de fer, l'oxyde de cérium, l'oxyde de zirconium et l'oxyde de bismuth. La teneur en acide polyhydroxystéarique représente de 0,5 à 8,0 % en poids du poids total de la dispersion. La quantité de composant à base de silicone mélangé n'est pas supérieure à 10,0 % en poids du poids total de la dispersion. Les particules d'oxyde inorganiques représentent au moins 51,0 % en poids du poids total de la dispersion.
PCT/JP2016/052199 2015-01-28 2016-01-26 Dispersion, son procédé de préparation et produit cosmétique WO2016121761A1 (fr)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108478806A (zh) * 2018-03-09 2018-09-04 哈尔滨工业大学深圳研究生院 中空介孔二氧化硅药物载体纳米孔道的可靠性封装制备方法
US20210315781A1 (en) * 2018-10-24 2021-10-14 Tayca Corporation Inorganic powder composite, method for producing same, water-in-oil emulsion composition, and sunscreen cosmetic

Citations (8)

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JPS647941A (en) * 1987-05-30 1989-01-11 Tioxide Group Plc Oil dispersion and its production
JPH05213618A (ja) * 1991-10-04 1993-08-24 Tioxide Specialties Ltd 酸化亜鉛粒子分散物
JP2006001886A (ja) * 2004-06-18 2006-01-05 Nikko Chemical Co Ltd 表面疎水化処理した金属酸化物油分散体
JP2012521442A (ja) * 2009-03-23 2012-09-13 コボ プロダクツ インコーポレイテッド 自己分散性金属酸化物コーティング粉末、その製造方法及び使用
JP2012184178A (ja) * 2011-03-03 2012-09-27 Kose Corp 微粒子金属酸化物分散組成物
JP2013071931A (ja) * 2011-09-29 2013-04-22 Kose Corp 油中水型乳化化粧料
JP2013071920A (ja) * 2011-09-28 2013-04-22 Kose Corp 水中油型乳化化粧料
JP2014080377A (ja) * 2012-10-12 2014-05-08 Kose Corp 水中油型乳化化粧料

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS647941A (en) * 1987-05-30 1989-01-11 Tioxide Group Plc Oil dispersion and its production
JPH05213618A (ja) * 1991-10-04 1993-08-24 Tioxide Specialties Ltd 酸化亜鉛粒子分散物
JP2006001886A (ja) * 2004-06-18 2006-01-05 Nikko Chemical Co Ltd 表面疎水化処理した金属酸化物油分散体
JP2012521442A (ja) * 2009-03-23 2012-09-13 コボ プロダクツ インコーポレイテッド 自己分散性金属酸化物コーティング粉末、その製造方法及び使用
JP2012184178A (ja) * 2011-03-03 2012-09-27 Kose Corp 微粒子金属酸化物分散組成物
JP2013071920A (ja) * 2011-09-28 2013-04-22 Kose Corp 水中油型乳化化粧料
JP2013071931A (ja) * 2011-09-29 2013-04-22 Kose Corp 油中水型乳化化粧料
JP2014080377A (ja) * 2012-10-12 2014-05-08 Kose Corp 水中油型乳化化粧料

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108478806A (zh) * 2018-03-09 2018-09-04 哈尔滨工业大学深圳研究生院 中空介孔二氧化硅药物载体纳米孔道的可靠性封装制备方法
US20210315781A1 (en) * 2018-10-24 2021-10-14 Tayca Corporation Inorganic powder composite, method for producing same, water-in-oil emulsion composition, and sunscreen cosmetic

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