WO2016056773A3 - L-글루타민을 생산하는 미생물 및 이를 이용한 l-글루타민 생산방법 - Google Patents

L-글루타민을 생산하는 미생물 및 이를 이용한 l-글루타민 생산방법 Download PDF

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WO2016056773A3
WO2016056773A3 PCT/KR2015/009909 KR2015009909W WO2016056773A3 WO 2016056773 A3 WO2016056773 A3 WO 2016056773A3 KR 2015009909 W KR2015009909 W KR 2015009909W WO 2016056773 A3 WO2016056773 A3 WO 2016056773A3
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glutamine
producing
same
microorganism
concentration
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PCT/KR2015/009909
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English (en)
French (fr)
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WO2016056773A2 (ko
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이진남
백승희
성진석
송태호
우하동
이경창
장재우
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씨제이제일제당 (주)
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Priority to AU2015328946A priority Critical patent/AU2015328946B2/en
Priority to RU2017109400A priority patent/RU2665830C1/ru
Priority to ES15848984T priority patent/ES2817933T3/es
Priority to CN201580055019.9A priority patent/CN107208038A/zh
Priority to EP15848984.9A priority patent/EP3205714B1/en
Priority to JP2017517032A priority patent/JP6483253B2/ja
Priority to MYPI2017000437A priority patent/MY182673A/en
Priority to US15/515,744 priority patent/US10023888B2/en
Priority to CA2963926A priority patent/CA2963926C/en
Publication of WO2016056773A2 publication Critical patent/WO2016056773A2/ko
Publication of WO2016056773A3 publication Critical patent/WO2016056773A3/ko

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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/14—Glutamic acid; Glutamine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/15—Corynebacterium
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/843—Corynebacterium

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Plant Pathology (AREA)
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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

본 발명은 고농도의 L-글루타민에 대해 내성을 가지는 코리네박테리움 글루타미쿰 (Corynebacterium glutamicum) 변이주 및 이를 이용한 L-글루타민 생산방법에 관한 것이다.
PCT/KR2015/009909 2014-10-08 2015-09-22 L-글루타민을 생산하는 미생물 및 이를 이용한 l-글루타민 생산방법 WO2016056773A2 (ko)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU2015328946A AU2015328946B2 (en) 2014-10-08 2015-09-22 Microorganism for producing L-glutamine and method for producing L-glutamine using same
RU2017109400A RU2665830C1 (ru) 2014-10-08 2015-09-22 Мутантный штамм Corynebacterium glutamicum, продуцирующий L-глутамин (варианты), и способ получения L-глутамина
ES15848984T ES2817933T3 (es) 2014-10-08 2015-09-22 Microorganismo de producción de L-glutamina y procedimiento de producción de L-glutamina utilizando el mismo
CN201580055019.9A CN107208038A (zh) 2014-10-08 2015-09-22 用于产生l‑谷氨酰胺的微生物及使用其产生l‑谷氨酰胺的方法
EP15848984.9A EP3205714B1 (en) 2014-10-08 2015-09-22 Microorganism for producing l-glutamine and method for producing l-glutamine using same
JP2017517032A JP6483253B2 (ja) 2014-10-08 2015-09-22 Ｌ−グルタミンを生産する微生物、及びそれを利用したｌ−グルタミン生産方法
MYPI2017000437A MY182673A (en) 2014-10-08 2015-09-22 Microorganism for producing l-glutamine and method for producing l-glutamine using same
US15/515,744 US10023888B2 (en) 2014-10-08 2015-09-22 Microorganism for producing L-glutamine and method for producing L-glutamine using same
CA2963926A CA2963926C (en) 2014-10-08 2015-09-22 Microorganism for producing l-glutamine and method for producing l-glutamine using same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020140135959A KR101694850B1 (ko) 2014-10-08 2014-10-08 L-글루타민을 생산하는 미생물 및 이를 이용한 l-글루타민 생산방법
KR10-2014-0135959 2014-10-08

Publications (2)

Publication Number Publication Date
WO2016056773A2 WO2016056773A2 (ko) 2016-04-14
WO2016056773A3 true WO2016056773A3 (ko) 2017-04-27

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PCT/KR2015/009909 WO2016056773A2 (ko) 2014-10-08 2015-09-22 L-글루타민을 생산하는 미생물 및 이를 이용한 l-글루타민 생산방법

Country Status (12)

Country Link
US (1) US10023888B2 (ko)
EP (1) EP3205714B1 (ko)
JP (1) JP6483253B2 (ko)
KR (1) KR101694850B1 (ko)
CN (1) CN107208038A (ko)
AU (1) AU2015328946B2 (ko)
CA (1) CA2963926C (ko)
ES (1) ES2817933T3 (ko)
HU (1) HUE051762T2 (ko)
MY (1) MY182673A (ko)
RU (1) RU2665830C1 (ko)
WO (1) WO2016056773A2 (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021384593A1 (en) * 2020-11-20 2023-06-08 Cj Cheiljedang Corporation Microorganism having enhanced l-glutamine producing ability, and l-glutamine producing method using same
CN117512029B (zh) * 2024-01-03 2024-03-29 地奥集团成都药业股份有限公司 一种提升谷氨酰胺产量的培养基、方法及代谢组学分析方法

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KR20050018797A (ko) * 2001-08-06 2005-02-28 데구사 아게 유전자 변형된 코리네박테리움 글루타미쿰 균주에 의한ｌ-리신의 생산
CN1710066A (zh) * 2005-06-07 2005-12-21 山东大学 一株可高产谷氨酰胺的谷氨酸棒杆菌
JP2007244392A (ja) * 1999-06-25 2007-09-27 Basf Ag コリネバクテリウム−グルタミカム遺伝子をコードするストレス、耐性および寛容性タンパク質
US20100184163A1 (en) * 2005-12-27 2010-07-22 Kyowa Hakko Kogyo Co., Ltd. Method for production of l-glutamine
KR20130082124A (ko) * 2012-01-10 2013-07-18 씨제이제일제당 (주) 자일로즈 이용능이 부여된 코리네박테리움 속 미생물 및 이를 이용한 ｌ-라이신의 생산방법
KR20140087201A (ko) * 2012-12-28 2014-07-09 대상 주식회사 Gogat의 불활성화에 의한 아미노산 고생산능 변이 균주

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JP2007244392A (ja) * 1999-06-25 2007-09-27 Basf Ag コリネバクテリウム−グルタミカム遺伝子をコードするストレス、耐性および寛容性タンパク質
KR20050018797A (ko) * 2001-08-06 2005-02-28 데구사 아게 유전자 변형된 코리네박테리움 글루타미쿰 균주에 의한ｌ-리신의 생산
CN1710066A (zh) * 2005-06-07 2005-12-21 山东大学 一株可高产谷氨酰胺的谷氨酸棒杆菌
US20100184163A1 (en) * 2005-12-27 2010-07-22 Kyowa Hakko Kogyo Co., Ltd. Method for production of l-glutamine
KR20130082124A (ko) * 2012-01-10 2013-07-18 씨제이제일제당 (주) 자일로즈 이용능이 부여된 코리네박테리움 속 미생물 및 이를 이용한 ｌ-라이신의 생산방법
KR20140087201A (ko) * 2012-12-28 2014-07-09 대상 주식회사 Gogat의 불활성화에 의한 아미노산 고생산능 변이 균주

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LIU, Q. ET AL.: "Microbial Production of L-glutamate and L-glutamine by Recom- binant Corynebacterium Glutamicum Harboring Vitreoscilla Hemoglobin Gene VGB", APPL. MICROBIOL. BIOTECHNOL., vol. 77, no. 6, 2008, pages 1297 - 1304, XP019586233 *

Also Published As

Publication number Publication date
US10023888B2 (en) 2018-07-17
CN107208038A (zh) 2017-09-26
CA2963926C (en) 2018-07-24
EP3205714A4 (en) 2018-03-07
ES2817933T3 (es) 2021-04-08
KR101694850B1 (ko) 2017-01-10
HUE051762T2 (hu) 2021-03-29
EP3205714B1 (en) 2020-08-05
JP2017529858A (ja) 2017-10-12
RU2665830C1 (ru) 2018-09-04
WO2016056773A2 (ko) 2016-04-14
CA2963926A1 (en) 2016-04-14
EP3205714A2 (en) 2017-08-16
AU2015328946B2 (en) 2018-10-18
US20170292135A1 (en) 2017-10-12
MY182673A (en) 2021-01-29
KR20160041624A (ko) 2016-04-18
AU2015328946A1 (en) 2017-05-25
JP6483253B2 (ja) 2019-03-13

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