WO2015186640A1 - ブリスターパック用積層体、それを用いたブリスターパック、及びブリスターパック包装体 - Google Patents

ブリスターパック用積層体、それを用いたブリスターパック、及びブリスターパック包装体 Download PDF

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WO2015186640A1
WO2015186640A1 PCT/JP2015/065654 JP2015065654W WO2015186640A1 WO 2015186640 A1 WO2015186640 A1 WO 2015186640A1 JP 2015065654 W JP2015065654 W JP 2015065654W WO 2015186640 A1 WO2015186640 A1 WO 2015186640A1
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Prior art keywords
layer
absorbent
laminate
blister pack
film
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PCT/JP2015/065654
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English (en)
French (fr)
Japanese (ja)
Inventor
海里 山▲崎▼
彰宏 木下
和巳 新井
みどり 加藤
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共同印刷株式会社
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Priority to JP2016525150A priority Critical patent/JPWO2015186640A1/ja
Publication of WO2015186640A1 publication Critical patent/WO2015186640A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators

Definitions

  • the present invention relates to a laminate for blister packs, a blister pack using the laminate, and a blister pack package.
  • the present invention relates to a blister pack laminate that does not cause molding defects even when a pocket having a depth is formed to wrap a large drug or the like, a blister pack using the same, and a blister pack package.
  • Powdered drugs are enclosed in thin paper bags or film bags, while drugs such as tablets or capsules are enclosed in blister packs called PTP (press-through packs).
  • PTP press-through packs
  • ⁇ Drugs may alter the medicinal properties by absorbing moisture. Therefore, conventionally, a desiccant such as silica gel has been enclosed in an outer bag enclosing a blister pack.
  • a desiccant such as silica gel has been enclosed in an outer bag enclosing a blister pack.
  • the operation of putting the desiccant into the outer bag takes time and there is a risk of accidental ingestion or accidental eating.
  • the inside of the blister pack cannot be kept at a low humidity, and there is a problem in that the deterioration of the drug progresses.
  • some chemicals are easily oxidatively decomposed, and others emit a specific odor. Therefore, there is a demand for absorbing gas such as oxygen and odor in the blister pack.
  • Patent Document 1 discloses a technique for improving the long-term stability of a drug by forming an adsorption layer having an adsorbent inside a blister pack.
  • a dome-shaped pocket portion is formed in a laminate of a base film including a barrier layer and an absorbent film including an adsorption layer.
  • medical agent which is a tablet is put into the pocket part, and this is sealed with the cover material. According to this technology, it is considered that it is possible to maintain a dry state, prevent oxidation, and efficiently remove odors without enclosing a desiccant or the like in the outer bag.
  • Patent Document 1 further discloses a technique for forming an aluminum layer not only on the cover material on the back side of the blister pack but also on the front blister pack laminate, so-called aluminum blister packaging. According to this technique, since the aluminum layer is formed on the blister pack, the drug cannot be visually recognized, but the ultraviolet ray can be blocked and the barrier property can be further enhanced.
  • Patent Document 2 inserts a reinforcing layer using a specific polymer between the aluminum layer of the base film and the absorbent film.
  • Patent Document 1 discloses a laminate having an absorption film containing a desiccant in two sub-adsorption layers (skin layers) sandwiching a main adsorption layer and a base film containing a barrier layer.
  • the content of the absorbent in the entire laminate can be increased, but since the surface of the sub-adsorption layer becomes rough, the adhesion between the base material layer and the sub-adsorption layer is deteriorated, and molding is performed. It has been found that as the depth is increased, so-called lami-floating is easily generated, in which the base material layer and the sub-adsorption layer are partially separated. In the portion where the lamellar float has occurred, the base material layer and the adsorption layer do not follow during molding, and the load during molding concentrates on the periphery, and the laminate tends to tear.
  • the shoulder portion of the pocket may still be torn or a pinhole may be generated. I understood.
  • the present invention provides a laminated body for blister packs that hardly causes molding defects even when pockets are formed to a certain depth for packaging contents such as large drugs, blister packs using the same, and blister packs
  • An object is to provide a package.
  • ⁇ 2> The laminate according to ⁇ 1>, wherein the arithmetic average roughness Ra of the surface of the first absorbent layer on the side opposite to the skin layer is 1.300 ⁇ m or less.
  • ⁇ 3> The above-mentioned ⁇ 1>, wherein the dynamic friction coefficient ⁇ D of the surface of the first absorption layer opposite to the skin layer of the ultrahigh molecular weight polyethylene when measured according to ISO8295 is 0.42 or less.
  • ⁇ 4> The laminate according to any one of ⁇ 1> to ⁇ 3>, wherein the heat-sealable first absorbent layer contains an inorganic absorbent in an amount of more than 28.8% by volume.
  • ⁇ 5> The above-described ⁇ 1> to ⁇ 4>, comprising a second absorbent layer containing an inorganic absorbent and a thermoplastic resin that is 70% by volume or less between the first absorbent layer and the skin layer.
  • the laminated body as described in any one.
  • the inorganic absorbent of the first absorbent layer and the second absorbent layer, and when present, the inorganic absorbent of the skin layer is zeolite, alumina, aluminum oxide, magnesium silicate, silica gel, calcium oxide , Calcium chloride, calcium sulfate, magnesium sulfate, sodium sulfate, calcium carbonate, magnesium oxide, barium oxide, diphosphorus pentoxide, magnesium perchlorate, potassium permanganate, sodium permanganate, sodium thiosulfate, iron powder, oxidation Ferrous iron, ferrous salt, sodium chloride, sodium bromide, sodium iodide, potassium chloride, potassium bromide, potassium iodide, calcium chloride, magnesium chloride, barium chloride, oxygen-deficient cerium oxide, sulfite, hydrogen sulfite A group of salts, nitrite and mixtures thereof
  • thermoplastic resin of the skin layer, the first absorbent layer, and the second absorbent layer is each independently selected from the group consisting of polyolefin resin, polyvinyl chloride, polystyrene, polycarbonate, polyamide, and mixtures thereof.
  • ⁇ 9> The laminate according to any one of ⁇ 1> to ⁇ 8> above, and a lid member having a thermoplastic resin layer and a metal layer, wherein the laminate and the lid member are at least partially A blister pack that is bonded and has a pocket portion formed in the laminate so that the contents can be stored between the laminate and the lid.
  • a blister pack package having the blister pack according to ⁇ 9> above and the contents stored in the pocket portion.
  • a blister pack having an absorbing function and having a deep pocket portion can be provided while suppressing the occurrence of molding defects.
  • the laminate for a blister pack of the present invention includes a base film and an absorbent film, and the absorbent film has the following layers: a thermoplastic resin and an inorganic absorbent content of less than 10% by volume.
  • the laminate of the present invention further includes a second absorbent layer containing a thermoplastic resin and an inorganic absorbent between the skin layer and the first absorbent layer.
  • the thickness of the laminate of the present invention is, for example, 250 ⁇ m or less, 200 ⁇ m or less, 150 ⁇ m or less, 100 ⁇ m or less from the viewpoint of the strength of the laminate, stiffness, push-through properties when formed into a blister pack package, barrier properties, etc. It can be 90 ⁇ m or less, 85 ⁇ m or less, or 80 ⁇ m or less, and can be 50 ⁇ m or more, 60 ⁇ m, or 70 ⁇ m or more.
  • the absorbent film preferably includes a first absorbent layer containing an inorganic absorbent and a thermoplastic resin, a second absorbent layer containing an inorganic absorbent and a thermoplastic resin, and a skin layer containing a thermoplastic resin. More preferably, a 2nd absorption layer contains more inorganic absorbers than a 1st absorption layer, and provides high absorbency to a laminated body. And preferably, the heat-sealability is imparted to the laminate by laminating the heat-sealable first absorbent layer on the second absorbent layer whose heat-sealability is impaired by the presence of a large amount of absorbent. To do. However, the content rate of the absorbent in the second absorption layer can be made lower than the content rate of the first absorption layer.
  • these layers include a thermoplastic resin, and examples of the resin include polyolefin resins, and in particular, low density polyethylene (LDPE), linear low density polyethylene (LLDPE), medium density polyethylene (MDPE), and high density.
  • Polyethylene (HDPE) polyethylene polymerized using metallocene catalyst, propylene homopolymer, propylene-ethylene block copolymer, propylene-ethylene random copolymer, polypropylene polymerized using metallocene catalyst, chlorinated polypropylene, polymethylpentene , Ethylene-acrylic acid copolymer (EEA), ethylene-methacrylic acid copolymer (EMAA), ethylene-ethyl acrylate copolymer (EEA), ethylene-methyl acrylate copolymer (EMA), ethylene-ethyl acrylate Polymer, ethylene-vinyl acetate copolymer (EVA), ionomer, carboxylic acid-modified polyethylene, carboxylic acid-modified poly
  • the absorbent film contains an inorganic absorbent, it can absorb at least one of liquid and gas.
  • the absorption target include moisture, organic and inorganic gases such as carbon dioxide, ammonia, hydrogen sulfide, oxygen, chlorine, hydrogen chloride and the like.
  • Examples of the inorganic absorbent contained in the first absorbent layer and the second absorbent layer include calcium oxide, calcium chloride, calcium sulfate, magnesium sulfate, sodium sulfate, calcium carbonate, magnesium oxide, barium oxide, diphosphorus pentoxide, excess Examples include chemical adsorbents such as magnesium chlorate, potassium permanganate, sodium permanganate, and sodium thiosulfate, and physical adsorbents such as alumina, aluminum oxide, magnesium silicate, quicklime, silica gel, and inorganic molecular sieves. .
  • inorganic molecular sieves include, but are not limited to, aluminosilicate minerals, clays, porous glass, microporous activated carbon, zeolite, activated carbon, or compounds having an open structure capable of diffusing small molecules such as water. Can be mentioned.
  • iron powder for example, reduced iron powder, sprayed iron powder, activated iron powder, etc.
  • iron-based oxygen absorbers such as ferrous oxide and ferrous salts, metal halides (for example, chloride) Sodium, sodium bromide, sodium iodide, potassium chloride, potassium bromide, potassium iodide, calcium chloride, magnesium chloride, barium chloride, etc.
  • oxygen-deficient cerium oxide for example, sulfite, bisulfite, nitrite, etc. Mention may also be made of oxygen scavengers.
  • zeolite is particularly preferable as the inorganic absorbent.
  • natural zeolite, artificial zeolite, or synthetic zeolite can be used.
  • Zeolite is a porous granular material used to separate substances according to the difference in molecular size, and has a structure with uniform pores. Therefore, water (water vapor), organic gas, etc. can be absorbed.
  • An example of a synthetic zeolite is a molecular sieve. Among these, a molecular sieve having a pore (absorption port) diameter of 0.3 nm to 1 nm can be used.
  • molecular sieves having pore sizes of 0.3 nm, 0.4 nm, 0.5 nm, and 1 nm are referred to as molecular sieve 3A, molecular sieve 4A, molecular sieve 5A, and molecular sieve 13X, respectively.
  • the average particle size of the inorganic absorbent (the particle size at an integrated value of 50% in the particle size distribution determined by the laser diffraction / scattering method) is not particularly limited.
  • the volume-based median diameter (d50) is 100 nm or more. 500 nm or more, 1 ⁇ m or more, or 5 ⁇ m or more, or 100 ⁇ m or less, 50 ⁇ m or less, 30 ⁇ m or less, or 15 ⁇ m or less.
  • the above-mentioned inorganic absorbent can be properly used according to the material to be absorbed, the properties of the contents, the surface roughness of the first absorbent layer, the intended absorption rate, and the like.
  • the absorption film including the first absorption layer and the skin layer can be manufactured by a multilayer inflation method.
  • This is a method for producing a multilayer film by extruding a plurality of resins into a tube shape at the same time by a plurality of extruders and sending the air into the tubes to inflate them.
  • an absorption film can be obtained by simultaneously molding the first absorption layer and the skin layer.
  • an absorption film including the first absorption layer, the second absorption layer, and the skin layer can also be produced by a multilayer inflation method.
  • the second absorbent layer is formed into a film or sheet by performing inflation method, T-die method, calendar method, casting method, press molding, extrusion molding or injection molding, and the skin layer and the first absorbent layer are formed respectively.
  • This three-layer absorption film can also be produced by forming a film by a known method and laminating the second absorption layer.
  • the thermoplastic resin and the inorganic absorbent are heat-kneaded in a biaxial kneader and then processed into a pellet.
  • a resin composition (pellet) for these layers is prepared.
  • the content of the inorganic absorbent may be adjusted by dry blending the pellets and the thermoplastic resin pellets.
  • an absorbent film is produced by forming a multilayer film by an inflation method.
  • the separately manufactured skin layer and the first absorption layer may be laminated by thermocompression bonding or the like to obtain an absorption film.
  • the film can be formed after preparing pellets containing an inorganic absorbent and a thermoplastic resin in advance. At this time, a skin layer may be co-extruded on one surface of the first absorbent layer to obtain an absorbent film.
  • the second absorbent layer When the second absorbent layer is included, the second absorbent layer may be co-extruded as necessary.
  • An absorption film may be obtained by extruding or laminating a film to be a second absorption layer separately manufactured by thermocompression bonding or the like.
  • the thickness of the absorption film is, for example, 200 ⁇ m or less, 150 ⁇ m or less, 100 ⁇ m or less, or 80 ⁇ m or less, and 30 ⁇ m or more, 40 ⁇ m, or 50 ⁇ m or more.
  • the thickness of 100 ⁇ m or less is preferable because the push-through property is good.
  • the arithmetic average roughness Ra of the first absorbent layer on the surface opposite to the skin layer is It is 0.700 ⁇ m or more.
  • a dome-shaped portion that becomes a pocket portion of the blister pack is formed in the laminate.
  • the method for forming the dome-shaped part include a flat plate air forming method, a plug assist pressure forming method, a drum vacuum forming method, a plug forming method, and the like.
  • a plug molding method using a cylindrical rod (plug material) having a round tip at a viscosity-average molecular weight of 1,000,000 or more is preferable for forming a pocket.
  • a crack may occur in the shoulder portion or the skirt portion of the dome-shaped pocket portion.
  • the inventors When the surface roughness of the first absorbent layer of the laminate absorbent film in contact with the plug material is small, the inventors crack the blister pack laminate with a high probability when forming the pocket portion. Found that occurs. That is, when the surface roughness of the first absorbent layer is small, friction occurs at the contact portion between the plug material and the first absorbent layer, and only the contact portion is greatly stretched, and a large tensile stress is applied to the laminate at that location. It is thought that cracks occur.
  • the present inventors increase the surface roughness of the first absorption layer of the absorption film to make the plug material slippery, so that when the plug material is pushed into the first absorption layer, the entire pushing surface is formed.
  • the present invention has been achieved by applying strain as uniformly as possible.
  • the first absorption layer is a layer welded to the lid material, it preferably has heat sealability, and a surface roughness that is too high may not be appropriate from the viewpoint of film formation.
  • the first absorbent layer of the present invention has an arithmetic mean roughness Ra of the surface of the first absorbent layer opposite to the skin layer in both the flow direction (MD) and the width direction (TD). For example, it can be 2.000 ⁇ m or less, 1.500 ⁇ m or less, 1.300 ⁇ m or less, or 1.200 ⁇ m or less.
  • the surface of the first absorbent layer opposite to the skin layer preferably has a low coefficient of dynamic friction.
  • the dynamic friction coefficient ⁇ D of the first absorbent layer on the surface opposite to the skin layer with ultrahigh molecular weight polyethylene when measured according to ISO8295 is 0.42 or less.
  • the ultra high molecular weight polyethylene is a polyethylene having a viscosity average molecular weight of 1 million or more measured based on JIS K7367-3: 1999, and particularly an ultra high molecular weight polyethylene resin having a molecular weight of 5.5 million (product name: Neulite ( Trademark) NL-W, Sakushin Kogyo Co., Ltd.). This is because it is the same as the ultrahigh molecular weight polyethylene usually used for the plug material used when molding the pocket portion of the blister pack.
  • the dynamic friction coefficient is small, sliding between the plug material and the first absorbent layer is improved during the formation of the pocket portion, and local strain at the contact portion between the plug material and the first absorbent layer is less likely to occur. .
  • the surface roughness and optionally the dynamic friction coefficient can be obtained not only by adding an inorganic absorbent to the first absorbent layer, but also by adding other substances to the first absorbent layer, surface treatment, processing, etc. Good.
  • the surface roughness and / or the dynamic friction coefficient is given by including an appropriate inorganic absorbent in an appropriate amount in the first absorption layer.
  • the first absorbent layer can contain a large amount of an inorganic absorbent as long as the film-forming property and the heat sealability are not impaired.
  • the first absorbent layer contains more than 28.8% by volume, It can be 30 volume% or more, 33 volume% or more, 35 volume% or more, 38 volume% or more, or 40 volume% or more.
  • the first absorbent layer has an inorganic absorbent in a range of, for example, less than 70.0% by volume, 65% by volume or less, 60% by volume or less, 55% by volume or less, or 50% by volume or less so as to have high heat sealability. May be included.
  • the plug material when the plug material is pushed into the first absorbent layer, it is presumed that a cushion effect derived from the flexibility of the thermoplastic resin of the first absorbent layer works, but the inorganic absorbent is applied to the first absorbent layer. If it is contained in an appropriate amount, it is considered that not only the cushioning effect of the thermoplastic resin of the first absorbent layer but also the cushioning property derived from the particles of the inorganic absorbent that disperses the stress appears. That is, when the convex part by the inorganic absorbent on the surface of the first absorbent layer receives a force from the plug material, the inorganic absorbent particles sink into the thermoplastic resin to absorb the stress, and this gradually disperses. The phenomenon of going on can be considered.
  • the specific gravity of the layer is obtained by measurement, the measured value, the inorganic absorbent and
  • the volume% of the inorganic absorbent may be determined from the added weight of the thermoplastic resin and the specific gravity of the thermoplastic resin. For example, when the specific gravity of a layer formed using 50 g of an inorganic absorbent and 50 g of a thermoplastic resin having a specific gravity of 0.9 g / cm 3 is 1.1 g / cm 3 , it is included in the layer.
  • the inorganic absorbent can be calculated to have a specific gravity of 1.41 g / cm 3, and it can be said that 38.9% by volume is present in the layer.
  • the thickness of the first absorption layer is, for example, 30 ⁇ m or less, 20 ⁇ m or less, or 15 ⁇ m or less, and 5 ⁇ m or more, 8 ⁇ m, or 10 ⁇ m or more.
  • the 2nd absorption layer can also be made into below the content rate of the inorganic absorber of a 1st absorption layer, it is preferable to make it into more than the content rate of the inorganic absorber of a 1st absorption layer.
  • the inorganic absorbent can be, for example, 5% by volume or more, 10% by volume or more, or 20% by volume or more in the second absorption layer. It can be made into the range of 70 volume% or less, 60 volume% or less, or 50 volume% or less.
  • the thickness of the second absorption layer is, for example, 10 ⁇ m or more, 20 ⁇ m or more, or 30 ⁇ m or more, and is 180 ⁇ m or less, 150 ⁇ m or less, 100 ⁇ m or less, or 80 ⁇ m or less, or 50 ⁇ m or less.
  • the thickness is preferably 80 ⁇ m or less because the push-through property is good.
  • the skin layer preferably does not contain an inorganic absorbent from the viewpoint of bonding with a layer adjacent to the skin layer, for example, a base material layer, a barrier layer, a reinforcing layer, or the like of the base film. If the skin layer contains a large amount of an inorganic absorbent, the surface of the skin layer becomes rough, and the adjacent layer and the skin layer tend to peel off, so-called lami-floating easily occurs. Even if it exists, it is preferable that it becomes 10 volume%, 7 volume%, 5 volume%, 3 volume%, or 1 volume% or less in the layer. If the volume is 10% by volume or less, the surface of the skin layer is not so rough, so that there is almost no occurrence of lami-floating between adjacent layers. high.
  • the thickness of the skin layer is, for example, 30 ⁇ m or less, 20 ⁇ m or less, or 15 ⁇ m or less, and 5 ⁇ m or more, 8 ⁇ m or more, or 10 ⁇ m or more.
  • the base film isolates the absorbent film from the external environment, and gives appropriate stiffness and strength to the entire laminate.
  • the base film may include a barrier layer having a metal layer in addition to the base layer, and may further include a reinforcing layer.
  • the base material layer includes a thermoplastic resin.
  • the thermoplastic resin include polyolefin resins, polyvinyl chloride, polyvinylidene chloride (PVDC), polychlorotrifluoroethylene, polytetrafluoroethylene, and saturated or unsaturated polyester.
  • PVDC polyvinylidene chloride
  • polychlorotrifluoroethylene polytetrafluoroethylene
  • saturated or unsaturated polyester
  • PET polyethylene terephthalate
  • polybutylene terephthalate polyamide
  • nylon registered trademark
  • nylon 6 nylon MXD6 nylon 6 nylon MXD6
  • PAN polyacrylonitrile
  • the barrier layer has a metal layer, and may be a layer including a pure aluminum (Al) foil or an aluminum alloy foil.
  • a thermoplastic resin film having at least a vapor-deposited layer of metal, metalloid or their oxide or a halogenated polymer layer can be used alone or in combination with the above film.
  • the vapor deposition layer of metal, metalloid or oxide thereof include aluminum vapor deposition film, silica vapor deposition film, alumina vapor deposition film, silica / alumina binary vapor deposition film, and the like.
  • Halogenated polymer layer examples thereof include a polyvinylidene chloride coating film and a polyvinylidene fluoride coating film.
  • polyolefin resins particularly stretched or unstretched polypropylene
  • polyvinyl chloride saturated polyesters (for example, polyethylene terephthalate (PET), polybutylene terephthalate), polyamides (for example, nylon (registered trademark)) , Nylon 6 and nylon MXD6).
  • saturated polyesters for example, polyethylene terephthalate (PET), polybutylene terephthalate
  • polyamides for example, nylon (registered trademark)
  • Nylon 6 and nylon MXD6 nylon MXD6
  • a film that can be used as a base material layer can also be used as a reinforcing layer.
  • polyamide, polyethylene terephthalate, and polyvinyl chloride are preferable.
  • the base film can be a laminated film of a PET film as a base layer and an Al foil as a barrier layer.
  • the PET film is used as the base layer and the Al foil is absorbed as a barrier layer. Position it on the film side.
  • the base film is the outermost layer of the PET film as the base layer, the Al foil as the barrier layer is positioned on the absorption film side of the PET film, and becomes a reinforcing layer between the Al foil and the absorption film. You may have a polyamide film.
  • the substrate film is a laminated film
  • a known lamination method such as dry lamination or extrusion lamination can be used as the lamination method.
  • the method for laminating the base film and the absorbent film is the same as that, and a known laminating method such as dry lamination or extrusion lamination can be used.
  • the thickness of the base film can be set to, for example, 150 ⁇ m or less, or 100 ⁇ m or less from the viewpoint of maintaining barrier properties and giving strength and the like to the entire laminate of the present invention, and is 20 ⁇ m or more, 30 ⁇ m, or 50 ⁇ m. This can be done.
  • the thickness of the base layer is, for example, 8 ⁇ m or more, 10 ⁇ m or more, or 12 ⁇ m or more. And can be 50 ⁇ m or less, or 25 ⁇ m or less.
  • the thickness of the barrier layer can be, for example, 7 ⁇ m or more, 10 ⁇ m or more, or 12 ⁇ m or more, and can be 50 ⁇ m or less, 45 ⁇ m or less, or 30 ⁇ m or less.
  • the thickness of the reinforcing layer can be, for example, 8 ⁇ m or more, 10 ⁇ m or more, or 12 ⁇ m or more, and can be 80 ⁇ m or less, 60 ⁇ m or less, 50 ⁇ m or less, or 25 ⁇ m or less.
  • the laminate for blister packs of the present invention may have a printing layer, an anchor coat layer for enhancing adhesion between two layers, and a primer layer between any two layers.
  • the blister pack of this invention has said laminated body for blister packs, and a cover material.
  • the first absorbent layer and the lid member of the blister pack laminate are at least partially bonded.
  • the pocket part for storing the contents such as tablets in the laminated body for blister pack
  • the medicine is stored in the pocket part
  • the lid material is adhered, and the contents are stored in the pocket part of the blister pack
  • a blister pack package can be produced.
  • the content of the blister pack of the present invention is not limited as long as it can be deteriorated by contact with the outside air, and examples thereof include foods, cosmetics, medical devices, electronic parts, and the like. Moreover, as a chemical
  • the lid member includes, for example, a thermoplastic resin layer and a metal layer.
  • a thermoplastic resin that can be used for the first absorption layer can be used.
  • an aluminum foil such as a pure aluminum foil or an aluminum alloy foil can be used.
  • the lid is in a form in which a thermoplastic resin layer is coated on an aluminum foil, and the thermoplastic resin layer of the lid and the layer (first absorption layer) to which the blister pack laminate is bonded are: From the viewpoint of improving adhesiveness, the same resin can be included.
  • an aluminum foil may be coated with an easy peel resin such as polyolefin polymer alloy, or an easy peel film may be laminated. In this case, the contents can be taken out by peeling at the bonding interface between the blister pack and the lid.
  • FIG. 1 is a schematic view of a blister pack 1.
  • the cover material 5 is bonded to the laminate 2 for blister pack formed by laminating the base film 3 and the absorbent film 4 in order, and the content is stored in the dome-shaped pocket portion formed in the laminate 2.
  • An object 100 is included.
  • an adhesive layer or an extrusion resin layer exists between the base film and the absorption film.
  • FIG. 2 is a schematic view of the layer structure of the blister pack 1 of the present invention.
  • the edge part in which the pocket part of the blister pack 1 is not formed is shown, and the base material layer 31, the barrier layer 32, the reinforcing layer 33, and the absorption film 4 of the base material film 3 are laminated in order.
  • a lid 5 is bonded to the blister pack laminate 2 formed as described above.
  • the absorbent film 4 is composed of a skin layer 41, a second absorbent layer 42, and a first absorbent layer 43
  • the lid member is composed of a thermoplastic resin layer 51 and a metal layer 52.
  • an inorganic absorbent zeolite (Union Showa Co., Ltd., zeolite 3A) and a thermoplastic resin EMAA (Mitsui-DuPont Polychemical Co., Ltd., Nukurell AN42115C) pellets are mixed into a twin-screw extruder (Ikegai Corporation, Using PCM70), pellets having a zeolite content of 53 wt% (45.6 vol%) for the second absorbent layer were obtained by kneading and pelletizing.
  • a twin-screw extruder Ikegai Corporation, Using PCM70
  • pellets of LLDPE manufactured by Prime Polymer Co., Ltd., Evolution SP2520
  • the first absorbent layer pellet and the second absorbent layer pellet are used to form a multilayer at 170 ° C.
  • an absorption film used in Comparative Examples 1 to 6 and Examples 7 to 10 was obtained using an inflation molding machine (Puraco Co., Ltd., TUL-600R).
  • the thickness of the skin layer was 10 ⁇ m.
  • These absorbent films include a base material layer, a barrier layer, and a reinforcing layer obtained by bonding a 25 ⁇ m nylon (Ny) film, a 40 ⁇ m aluminum (Al) foil, and a 60 ⁇ m polyvinyl chloride (PVC) film with an adhesive.
  • a base film manufactured by UACJ Co., Ltd., product name: AL / AL Yoki
  • was laminated using a dry laminator manufactured by Techno Smart Co., Ltd., INVEX pilot coater).
  • the adhesive the main agent (Mitsui Chemicals, Takelac (trademark) A1143), the curing agent (Mitsui Chemicals, Takenate (trademark) A3), and ethyl acetate were respectively 9: 1: 14.7.
  • a urethane-based adhesive contained in a weight ratio was used. The amount of adhesive applied was 5 g / m 2 . After the lamination, in order to cure the adhesive, it was aged by storing for 3 days in an environment of 40 ° C.
  • a pocket portion of the contents having a depth of 5.00 to 5.50 mm at room temperature was formed on the laminate thus obtained.
  • a high-speed hydraulic press (HYP505H) manufactured by Nippon Automatic Machine Co., Ltd. was used as the molding machine.
  • the plug material is ultra high molecular weight polyethylene resin (product name: Newlite (trademark) NL-W, Sakushin Kogyo Co., Ltd.) having a viscosity average molecular weight of 5.5 million, the plug diameter is 13 mm, and the molding speed is 200 mm / s. .
  • the test was performed 10 times for each depth in each example, and it was visually determined how many molding defects such as cracks, scratches, and dents occurred in the molded pocket.
  • the case where molding was possible without forming defects in all 10 times was marked as ⁇
  • the case where molding was possible in 8-9 times was marked as ⁇
  • the case where molding was possible in 5-7 times was marked as ⁇
  • the case where molding was possible only 4 times or less was marked as x.
  • the test results are shown in Table 1.
  • the measurement speed is 100 mm / min, the sliding piece is 200 g (40 cm 2 ), the sample is an ultra-high molecular weight PE film (viscosity average molecular weight 5.5 million, product name: Newlite film # 50W, resin used) : Newlite (trademark) NL-W Sakushin Kogyo Co., Ltd., arithmetic average roughness Ra: MD direction 0.067 ⁇ m, TD direction 0.073 ⁇ m).
  • the test results are shown in Table 1 together with the value of the static friction coefficient ⁇ S measured in the same manner.
  • Comparative Examples 1 to 6 it can be seen that many molding defects occur when a deep pocket portion of 5.50 mm is formed. Further, compared to Comparative Examples 1 and 2 in which the absorbent is not contained in the first absorbent layer, Comparative Examples 3 to 6 containing the absorbent tend to cause molding defects more easily. ing.
  • the first absorbent layer contains the inorganic absorbent in an appropriate amount, the inorganic absorbent particles when receiving force from the plug material. It is considered that the cushioning effect of the inorganic absorbent and the resin, which absorbs and disperses the stress in cooperation with the resin, appears more prominently than the decrease in the cushioning effect by the resin.
  • the absorption rate is remarkably improved as compared with the laminates of Comparative Examples 1 to 6, and it is necessary to create a deep pocket portion, and strongly influence the atmosphere. It can be seen that it is extremely effective when forming a blister pack for storing the contents to be received.
  • 3 and 4 show a comparison of the absorption rates of the laminates having the first absorption layer having a thickness of 10 ⁇ m and 20 ⁇ m, respectively.
  • the absorption rate and the absorption amount are improved as compared with the laminate of the comparative example.

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PCT/JP2015/065654 2014-06-05 2015-05-29 ブリスターパック用積層体、それを用いたブリスターパック、及びブリスターパック包装体 WO2015186640A1 (ja)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016152836A1 (ja) * 2015-03-26 2016-09-29 東洋紡株式会社 ポリエチレン系フィルム
WO2016152835A1 (ja) * 2015-03-26 2016-09-29 東洋紡株式会社 ポリエチレン系フィルム
JP2017226123A (ja) * 2016-06-21 2017-12-28 共同印刷株式会社 酸素吸収性フィルム
JP2019010775A (ja) * 2017-06-29 2019-01-24 共同印刷株式会社 吸湿及びガス吸着用フィルム、並びに包装用積層体
JP2020163745A (ja) * 2019-03-29 2020-10-08 大日本印刷株式会社 炭酸ガス吸収積層体とバルブレス包装体
JP7380215B2 (ja) 2019-12-27 2023-11-15 大日本印刷株式会社 容器用包装体及びその製造方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004224430A (ja) * 2003-01-27 2004-08-12 Sumitomo Bakelite Co Ltd Ｐｔｐ包装用シート
JP2005530657A (ja) * 2002-06-26 2005-10-13 ジョンソン・アンド・ジョンソン・ビジョン・ケア・インコーポレイテッド コンタクトレンズ・パッケージ
WO2006115264A1 (ja) * 2005-04-26 2006-11-02 Daiichi Sankyo Company, Limited Ｐｔｐ又はブリスターパック用フィルム及びｐｔｐ又はブリスターパック用包装容器
WO2012029323A1 (ja) * 2010-09-01 2012-03-08 共同印刷株式会社 積層体、包装容器、及び包装体
JP2013216331A (ja) * 2012-04-04 2013-10-24 Asahi Kasei Chemicals Corp プレススルーパック包装体用蓋材及び包装体

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005530657A (ja) * 2002-06-26 2005-10-13 ジョンソン・アンド・ジョンソン・ビジョン・ケア・インコーポレイテッド コンタクトレンズ・パッケージ
JP2004224430A (ja) * 2003-01-27 2004-08-12 Sumitomo Bakelite Co Ltd Ｐｔｐ包装用シート
WO2006115264A1 (ja) * 2005-04-26 2006-11-02 Daiichi Sankyo Company, Limited Ｐｔｐ又はブリスターパック用フィルム及びｐｔｐ又はブリスターパック用包装容器
WO2012029323A1 (ja) * 2010-09-01 2012-03-08 共同印刷株式会社 積層体、包装容器、及び包装体
JP2013216331A (ja) * 2012-04-04 2013-10-24 Asahi Kasei Chemicals Corp プレススルーパック包装体用蓋材及び包装体

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016152836A1 (ja) * 2015-03-26 2016-09-29 東洋紡株式会社 ポリエチレン系フィルム
WO2016152835A1 (ja) * 2015-03-26 2016-09-29 東洋紡株式会社 ポリエチレン系フィルム
JPWO2016152835A1 (ja) * 2015-03-26 2018-05-17 東洋紡株式会社 ポリエチレン系フィルム
US10556407B2 (en) 2015-03-26 2020-02-11 Toyobo Co., Ltd. Polyethylene film
US10556409B2 (en) 2015-03-26 2020-02-11 Toyobo Co., Ltd. Polyethylene film
JP2017226123A (ja) * 2016-06-21 2017-12-28 共同印刷株式会社 酸素吸収性フィルム
JP2019010775A (ja) * 2017-06-29 2019-01-24 共同印刷株式会社 吸湿及びガス吸着用フィルム、並びに包装用積層体
JP2020163745A (ja) * 2019-03-29 2020-10-08 大日本印刷株式会社 炭酸ガス吸収積層体とバルブレス包装体
JP7371341B2 (ja) 2019-03-29 2023-10-31 大日本印刷株式会社 炭酸ガス吸収積層体とバルブレス包装体
JP7380215B2 (ja) 2019-12-27 2023-11-15 大日本印刷株式会社 容器用包装体及びその製造方法

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