WO2015186640A1 - Laminate for use in blister pack, blister pack using same, and blister pack packaging - Google Patents

Laminate for use in blister pack, blister pack using same, and blister pack packaging Download PDF

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Publication number
WO2015186640A1
WO2015186640A1 PCT/JP2015/065654 JP2015065654W WO2015186640A1 WO 2015186640 A1 WO2015186640 A1 WO 2015186640A1 JP 2015065654 W JP2015065654 W JP 2015065654W WO 2015186640 A1 WO2015186640 A1 WO 2015186640A1
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WIPO (PCT)
Prior art keywords
layer
absorbent
laminate
blister pack
film
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PCT/JP2015/065654
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French (fr)
Japanese (ja)
Inventor
海里 山▲崎▼
彰宏 木下
和巳 新井
みどり 加藤
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共同印刷株式会社
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Priority to JP2016525150A priority Critical patent/JPWO2015186640A1/en
Publication of WO2015186640A1 publication Critical patent/WO2015186640A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/18—Layered products comprising a layer of synthetic resin characterised by the use of special additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators

Definitions

  • the present invention relates to a laminate for blister packs, a blister pack using the laminate, and a blister pack package.
  • the present invention relates to a blister pack laminate that does not cause molding defects even when a pocket having a depth is formed to wrap a large drug or the like, a blister pack using the same, and a blister pack package.
  • Powdered drugs are enclosed in thin paper bags or film bags, while drugs such as tablets or capsules are enclosed in blister packs called PTP (press-through packs).
  • PTP press-through packs
  • ⁇ Drugs may alter the medicinal properties by absorbing moisture. Therefore, conventionally, a desiccant such as silica gel has been enclosed in an outer bag enclosing a blister pack.
  • a desiccant such as silica gel has been enclosed in an outer bag enclosing a blister pack.
  • the operation of putting the desiccant into the outer bag takes time and there is a risk of accidental ingestion or accidental eating.
  • the inside of the blister pack cannot be kept at a low humidity, and there is a problem in that the deterioration of the drug progresses.
  • some chemicals are easily oxidatively decomposed, and others emit a specific odor. Therefore, there is a demand for absorbing gas such as oxygen and odor in the blister pack.
  • Patent Document 1 discloses a technique for improving the long-term stability of a drug by forming an adsorption layer having an adsorbent inside a blister pack.
  • a dome-shaped pocket portion is formed in a laminate of a base film including a barrier layer and an absorbent film including an adsorption layer.
  • medical agent which is a tablet is put into the pocket part, and this is sealed with the cover material. According to this technology, it is considered that it is possible to maintain a dry state, prevent oxidation, and efficiently remove odors without enclosing a desiccant or the like in the outer bag.
  • Patent Document 1 further discloses a technique for forming an aluminum layer not only on the cover material on the back side of the blister pack but also on the front blister pack laminate, so-called aluminum blister packaging. According to this technique, since the aluminum layer is formed on the blister pack, the drug cannot be visually recognized, but the ultraviolet ray can be blocked and the barrier property can be further enhanced.
  • Patent Document 2 inserts a reinforcing layer using a specific polymer between the aluminum layer of the base film and the absorbent film.
  • Patent Document 1 discloses a laminate having an absorption film containing a desiccant in two sub-adsorption layers (skin layers) sandwiching a main adsorption layer and a base film containing a barrier layer.
  • the content of the absorbent in the entire laminate can be increased, but since the surface of the sub-adsorption layer becomes rough, the adhesion between the base material layer and the sub-adsorption layer is deteriorated, and molding is performed. It has been found that as the depth is increased, so-called lami-floating is easily generated, in which the base material layer and the sub-adsorption layer are partially separated. In the portion where the lamellar float has occurred, the base material layer and the adsorption layer do not follow during molding, and the load during molding concentrates on the periphery, and the laminate tends to tear.
  • the shoulder portion of the pocket may still be torn or a pinhole may be generated. I understood.
  • the present invention provides a laminated body for blister packs that hardly causes molding defects even when pockets are formed to a certain depth for packaging contents such as large drugs, blister packs using the same, and blister packs
  • An object is to provide a package.
  • ⁇ 2> The laminate according to ⁇ 1>, wherein the arithmetic average roughness Ra of the surface of the first absorbent layer on the side opposite to the skin layer is 1.300 ⁇ m or less.
  • ⁇ 3> The above-mentioned ⁇ 1>, wherein the dynamic friction coefficient ⁇ D of the surface of the first absorption layer opposite to the skin layer of the ultrahigh molecular weight polyethylene when measured according to ISO8295 is 0.42 or less.
  • ⁇ 4> The laminate according to any one of ⁇ 1> to ⁇ 3>, wherein the heat-sealable first absorbent layer contains an inorganic absorbent in an amount of more than 28.8% by volume.
  • ⁇ 5> The above-described ⁇ 1> to ⁇ 4>, comprising a second absorbent layer containing an inorganic absorbent and a thermoplastic resin that is 70% by volume or less between the first absorbent layer and the skin layer.
  • the laminated body as described in any one.
  • the inorganic absorbent of the first absorbent layer and the second absorbent layer, and when present, the inorganic absorbent of the skin layer is zeolite, alumina, aluminum oxide, magnesium silicate, silica gel, calcium oxide , Calcium chloride, calcium sulfate, magnesium sulfate, sodium sulfate, calcium carbonate, magnesium oxide, barium oxide, diphosphorus pentoxide, magnesium perchlorate, potassium permanganate, sodium permanganate, sodium thiosulfate, iron powder, oxidation Ferrous iron, ferrous salt, sodium chloride, sodium bromide, sodium iodide, potassium chloride, potassium bromide, potassium iodide, calcium chloride, magnesium chloride, barium chloride, oxygen-deficient cerium oxide, sulfite, hydrogen sulfite A group of salts, nitrite and mixtures thereof
  • thermoplastic resin of the skin layer, the first absorbent layer, and the second absorbent layer is each independently selected from the group consisting of polyolefin resin, polyvinyl chloride, polystyrene, polycarbonate, polyamide, and mixtures thereof.
  • ⁇ 9> The laminate according to any one of ⁇ 1> to ⁇ 8> above, and a lid member having a thermoplastic resin layer and a metal layer, wherein the laminate and the lid member are at least partially A blister pack that is bonded and has a pocket portion formed in the laminate so that the contents can be stored between the laminate and the lid.
  • a blister pack package having the blister pack according to ⁇ 9> above and the contents stored in the pocket portion.
  • a blister pack having an absorbing function and having a deep pocket portion can be provided while suppressing the occurrence of molding defects.
  • the laminate for a blister pack of the present invention includes a base film and an absorbent film, and the absorbent film has the following layers: a thermoplastic resin and an inorganic absorbent content of less than 10% by volume.
  • the laminate of the present invention further includes a second absorbent layer containing a thermoplastic resin and an inorganic absorbent between the skin layer and the first absorbent layer.
  • the thickness of the laminate of the present invention is, for example, 250 ⁇ m or less, 200 ⁇ m or less, 150 ⁇ m or less, 100 ⁇ m or less from the viewpoint of the strength of the laminate, stiffness, push-through properties when formed into a blister pack package, barrier properties, etc. It can be 90 ⁇ m or less, 85 ⁇ m or less, or 80 ⁇ m or less, and can be 50 ⁇ m or more, 60 ⁇ m, or 70 ⁇ m or more.
  • the absorbent film preferably includes a first absorbent layer containing an inorganic absorbent and a thermoplastic resin, a second absorbent layer containing an inorganic absorbent and a thermoplastic resin, and a skin layer containing a thermoplastic resin. More preferably, a 2nd absorption layer contains more inorganic absorbers than a 1st absorption layer, and provides high absorbency to a laminated body. And preferably, the heat-sealability is imparted to the laminate by laminating the heat-sealable first absorbent layer on the second absorbent layer whose heat-sealability is impaired by the presence of a large amount of absorbent. To do. However, the content rate of the absorbent in the second absorption layer can be made lower than the content rate of the first absorption layer.
  • these layers include a thermoplastic resin, and examples of the resin include polyolefin resins, and in particular, low density polyethylene (LDPE), linear low density polyethylene (LLDPE), medium density polyethylene (MDPE), and high density.
  • Polyethylene (HDPE) polyethylene polymerized using metallocene catalyst, propylene homopolymer, propylene-ethylene block copolymer, propylene-ethylene random copolymer, polypropylene polymerized using metallocene catalyst, chlorinated polypropylene, polymethylpentene , Ethylene-acrylic acid copolymer (EEA), ethylene-methacrylic acid copolymer (EMAA), ethylene-ethyl acrylate copolymer (EEA), ethylene-methyl acrylate copolymer (EMA), ethylene-ethyl acrylate Polymer, ethylene-vinyl acetate copolymer (EVA), ionomer, carboxylic acid-modified polyethylene, carboxylic acid-modified poly
  • the absorbent film contains an inorganic absorbent, it can absorb at least one of liquid and gas.
  • the absorption target include moisture, organic and inorganic gases such as carbon dioxide, ammonia, hydrogen sulfide, oxygen, chlorine, hydrogen chloride and the like.
  • Examples of the inorganic absorbent contained in the first absorbent layer and the second absorbent layer include calcium oxide, calcium chloride, calcium sulfate, magnesium sulfate, sodium sulfate, calcium carbonate, magnesium oxide, barium oxide, diphosphorus pentoxide, excess Examples include chemical adsorbents such as magnesium chlorate, potassium permanganate, sodium permanganate, and sodium thiosulfate, and physical adsorbents such as alumina, aluminum oxide, magnesium silicate, quicklime, silica gel, and inorganic molecular sieves. .
  • inorganic molecular sieves include, but are not limited to, aluminosilicate minerals, clays, porous glass, microporous activated carbon, zeolite, activated carbon, or compounds having an open structure capable of diffusing small molecules such as water. Can be mentioned.
  • iron powder for example, reduced iron powder, sprayed iron powder, activated iron powder, etc.
  • iron-based oxygen absorbers such as ferrous oxide and ferrous salts, metal halides (for example, chloride) Sodium, sodium bromide, sodium iodide, potassium chloride, potassium bromide, potassium iodide, calcium chloride, magnesium chloride, barium chloride, etc.
  • oxygen-deficient cerium oxide for example, sulfite, bisulfite, nitrite, etc. Mention may also be made of oxygen scavengers.
  • zeolite is particularly preferable as the inorganic absorbent.
  • natural zeolite, artificial zeolite, or synthetic zeolite can be used.
  • Zeolite is a porous granular material used to separate substances according to the difference in molecular size, and has a structure with uniform pores. Therefore, water (water vapor), organic gas, etc. can be absorbed.
  • An example of a synthetic zeolite is a molecular sieve. Among these, a molecular sieve having a pore (absorption port) diameter of 0.3 nm to 1 nm can be used.
  • molecular sieves having pore sizes of 0.3 nm, 0.4 nm, 0.5 nm, and 1 nm are referred to as molecular sieve 3A, molecular sieve 4A, molecular sieve 5A, and molecular sieve 13X, respectively.
  • the average particle size of the inorganic absorbent (the particle size at an integrated value of 50% in the particle size distribution determined by the laser diffraction / scattering method) is not particularly limited.
  • the volume-based median diameter (d50) is 100 nm or more. 500 nm or more, 1 ⁇ m or more, or 5 ⁇ m or more, or 100 ⁇ m or less, 50 ⁇ m or less, 30 ⁇ m or less, or 15 ⁇ m or less.
  • the above-mentioned inorganic absorbent can be properly used according to the material to be absorbed, the properties of the contents, the surface roughness of the first absorbent layer, the intended absorption rate, and the like.
  • the absorption film including the first absorption layer and the skin layer can be manufactured by a multilayer inflation method.
  • This is a method for producing a multilayer film by extruding a plurality of resins into a tube shape at the same time by a plurality of extruders and sending the air into the tubes to inflate them.
  • an absorption film can be obtained by simultaneously molding the first absorption layer and the skin layer.
  • an absorption film including the first absorption layer, the second absorption layer, and the skin layer can also be produced by a multilayer inflation method.
  • the second absorbent layer is formed into a film or sheet by performing inflation method, T-die method, calendar method, casting method, press molding, extrusion molding or injection molding, and the skin layer and the first absorbent layer are formed respectively.
  • This three-layer absorption film can also be produced by forming a film by a known method and laminating the second absorption layer.
  • the thermoplastic resin and the inorganic absorbent are heat-kneaded in a biaxial kneader and then processed into a pellet.
  • a resin composition (pellet) for these layers is prepared.
  • the content of the inorganic absorbent may be adjusted by dry blending the pellets and the thermoplastic resin pellets.
  • an absorbent film is produced by forming a multilayer film by an inflation method.
  • the separately manufactured skin layer and the first absorption layer may be laminated by thermocompression bonding or the like to obtain an absorption film.
  • the film can be formed after preparing pellets containing an inorganic absorbent and a thermoplastic resin in advance. At this time, a skin layer may be co-extruded on one surface of the first absorbent layer to obtain an absorbent film.
  • the second absorbent layer When the second absorbent layer is included, the second absorbent layer may be co-extruded as necessary.
  • An absorption film may be obtained by extruding or laminating a film to be a second absorption layer separately manufactured by thermocompression bonding or the like.
  • the thickness of the absorption film is, for example, 200 ⁇ m or less, 150 ⁇ m or less, 100 ⁇ m or less, or 80 ⁇ m or less, and 30 ⁇ m or more, 40 ⁇ m, or 50 ⁇ m or more.
  • the thickness of 100 ⁇ m or less is preferable because the push-through property is good.
  • the arithmetic average roughness Ra of the first absorbent layer on the surface opposite to the skin layer is It is 0.700 ⁇ m or more.
  • a dome-shaped portion that becomes a pocket portion of the blister pack is formed in the laminate.
  • the method for forming the dome-shaped part include a flat plate air forming method, a plug assist pressure forming method, a drum vacuum forming method, a plug forming method, and the like.
  • a plug molding method using a cylindrical rod (plug material) having a round tip at a viscosity-average molecular weight of 1,000,000 or more is preferable for forming a pocket.
  • a crack may occur in the shoulder portion or the skirt portion of the dome-shaped pocket portion.
  • the inventors When the surface roughness of the first absorbent layer of the laminate absorbent film in contact with the plug material is small, the inventors crack the blister pack laminate with a high probability when forming the pocket portion. Found that occurs. That is, when the surface roughness of the first absorbent layer is small, friction occurs at the contact portion between the plug material and the first absorbent layer, and only the contact portion is greatly stretched, and a large tensile stress is applied to the laminate at that location. It is thought that cracks occur.
  • the present inventors increase the surface roughness of the first absorption layer of the absorption film to make the plug material slippery, so that when the plug material is pushed into the first absorption layer, the entire pushing surface is formed.
  • the present invention has been achieved by applying strain as uniformly as possible.
  • the first absorption layer is a layer welded to the lid material, it preferably has heat sealability, and a surface roughness that is too high may not be appropriate from the viewpoint of film formation.
  • the first absorbent layer of the present invention has an arithmetic mean roughness Ra of the surface of the first absorbent layer opposite to the skin layer in both the flow direction (MD) and the width direction (TD). For example, it can be 2.000 ⁇ m or less, 1.500 ⁇ m or less, 1.300 ⁇ m or less, or 1.200 ⁇ m or less.
  • the surface of the first absorbent layer opposite to the skin layer preferably has a low coefficient of dynamic friction.
  • the dynamic friction coefficient ⁇ D of the first absorbent layer on the surface opposite to the skin layer with ultrahigh molecular weight polyethylene when measured according to ISO8295 is 0.42 or less.
  • the ultra high molecular weight polyethylene is a polyethylene having a viscosity average molecular weight of 1 million or more measured based on JIS K7367-3: 1999, and particularly an ultra high molecular weight polyethylene resin having a molecular weight of 5.5 million (product name: Neulite ( Trademark) NL-W, Sakushin Kogyo Co., Ltd.). This is because it is the same as the ultrahigh molecular weight polyethylene usually used for the plug material used when molding the pocket portion of the blister pack.
  • the dynamic friction coefficient is small, sliding between the plug material and the first absorbent layer is improved during the formation of the pocket portion, and local strain at the contact portion between the plug material and the first absorbent layer is less likely to occur. .
  • the surface roughness and optionally the dynamic friction coefficient can be obtained not only by adding an inorganic absorbent to the first absorbent layer, but also by adding other substances to the first absorbent layer, surface treatment, processing, etc. Good.
  • the surface roughness and / or the dynamic friction coefficient is given by including an appropriate inorganic absorbent in an appropriate amount in the first absorption layer.
  • the first absorbent layer can contain a large amount of an inorganic absorbent as long as the film-forming property and the heat sealability are not impaired.
  • the first absorbent layer contains more than 28.8% by volume, It can be 30 volume% or more, 33 volume% or more, 35 volume% or more, 38 volume% or more, or 40 volume% or more.
  • the first absorbent layer has an inorganic absorbent in a range of, for example, less than 70.0% by volume, 65% by volume or less, 60% by volume or less, 55% by volume or less, or 50% by volume or less so as to have high heat sealability. May be included.
  • the plug material when the plug material is pushed into the first absorbent layer, it is presumed that a cushion effect derived from the flexibility of the thermoplastic resin of the first absorbent layer works, but the inorganic absorbent is applied to the first absorbent layer. If it is contained in an appropriate amount, it is considered that not only the cushioning effect of the thermoplastic resin of the first absorbent layer but also the cushioning property derived from the particles of the inorganic absorbent that disperses the stress appears. That is, when the convex part by the inorganic absorbent on the surface of the first absorbent layer receives a force from the plug material, the inorganic absorbent particles sink into the thermoplastic resin to absorb the stress, and this gradually disperses. The phenomenon of going on can be considered.
  • the specific gravity of the layer is obtained by measurement, the measured value, the inorganic absorbent and
  • the volume% of the inorganic absorbent may be determined from the added weight of the thermoplastic resin and the specific gravity of the thermoplastic resin. For example, when the specific gravity of a layer formed using 50 g of an inorganic absorbent and 50 g of a thermoplastic resin having a specific gravity of 0.9 g / cm 3 is 1.1 g / cm 3 , it is included in the layer.
  • the inorganic absorbent can be calculated to have a specific gravity of 1.41 g / cm 3, and it can be said that 38.9% by volume is present in the layer.
  • the thickness of the first absorption layer is, for example, 30 ⁇ m or less, 20 ⁇ m or less, or 15 ⁇ m or less, and 5 ⁇ m or more, 8 ⁇ m, or 10 ⁇ m or more.
  • the 2nd absorption layer can also be made into below the content rate of the inorganic absorber of a 1st absorption layer, it is preferable to make it into more than the content rate of the inorganic absorber of a 1st absorption layer.
  • the inorganic absorbent can be, for example, 5% by volume or more, 10% by volume or more, or 20% by volume or more in the second absorption layer. It can be made into the range of 70 volume% or less, 60 volume% or less, or 50 volume% or less.
  • the thickness of the second absorption layer is, for example, 10 ⁇ m or more, 20 ⁇ m or more, or 30 ⁇ m or more, and is 180 ⁇ m or less, 150 ⁇ m or less, 100 ⁇ m or less, or 80 ⁇ m or less, or 50 ⁇ m or less.
  • the thickness is preferably 80 ⁇ m or less because the push-through property is good.
  • the skin layer preferably does not contain an inorganic absorbent from the viewpoint of bonding with a layer adjacent to the skin layer, for example, a base material layer, a barrier layer, a reinforcing layer, or the like of the base film. If the skin layer contains a large amount of an inorganic absorbent, the surface of the skin layer becomes rough, and the adjacent layer and the skin layer tend to peel off, so-called lami-floating easily occurs. Even if it exists, it is preferable that it becomes 10 volume%, 7 volume%, 5 volume%, 3 volume%, or 1 volume% or less in the layer. If the volume is 10% by volume or less, the surface of the skin layer is not so rough, so that there is almost no occurrence of lami-floating between adjacent layers. high.
  • the thickness of the skin layer is, for example, 30 ⁇ m or less, 20 ⁇ m or less, or 15 ⁇ m or less, and 5 ⁇ m or more, 8 ⁇ m or more, or 10 ⁇ m or more.
  • the base film isolates the absorbent film from the external environment, and gives appropriate stiffness and strength to the entire laminate.
  • the base film may include a barrier layer having a metal layer in addition to the base layer, and may further include a reinforcing layer.
  • the base material layer includes a thermoplastic resin.
  • the thermoplastic resin include polyolefin resins, polyvinyl chloride, polyvinylidene chloride (PVDC), polychlorotrifluoroethylene, polytetrafluoroethylene, and saturated or unsaturated polyester.
  • PVDC polyvinylidene chloride
  • polychlorotrifluoroethylene polytetrafluoroethylene
  • saturated or unsaturated polyester
  • PET polyethylene terephthalate
  • polybutylene terephthalate polyamide
  • nylon registered trademark
  • nylon 6 nylon MXD6 nylon 6 nylon MXD6
  • PAN polyacrylonitrile
  • the barrier layer has a metal layer, and may be a layer including a pure aluminum (Al) foil or an aluminum alloy foil.
  • a thermoplastic resin film having at least a vapor-deposited layer of metal, metalloid or their oxide or a halogenated polymer layer can be used alone or in combination with the above film.
  • the vapor deposition layer of metal, metalloid or oxide thereof include aluminum vapor deposition film, silica vapor deposition film, alumina vapor deposition film, silica / alumina binary vapor deposition film, and the like.
  • Halogenated polymer layer examples thereof include a polyvinylidene chloride coating film and a polyvinylidene fluoride coating film.
  • polyolefin resins particularly stretched or unstretched polypropylene
  • polyvinyl chloride saturated polyesters (for example, polyethylene terephthalate (PET), polybutylene terephthalate), polyamides (for example, nylon (registered trademark)) , Nylon 6 and nylon MXD6).
  • saturated polyesters for example, polyethylene terephthalate (PET), polybutylene terephthalate
  • polyamides for example, nylon (registered trademark)
  • Nylon 6 and nylon MXD6 nylon MXD6
  • a film that can be used as a base material layer can also be used as a reinforcing layer.
  • polyamide, polyethylene terephthalate, and polyvinyl chloride are preferable.
  • the base film can be a laminated film of a PET film as a base layer and an Al foil as a barrier layer.
  • the PET film is used as the base layer and the Al foil is absorbed as a barrier layer. Position it on the film side.
  • the base film is the outermost layer of the PET film as the base layer, the Al foil as the barrier layer is positioned on the absorption film side of the PET film, and becomes a reinforcing layer between the Al foil and the absorption film. You may have a polyamide film.
  • the substrate film is a laminated film
  • a known lamination method such as dry lamination or extrusion lamination can be used as the lamination method.
  • the method for laminating the base film and the absorbent film is the same as that, and a known laminating method such as dry lamination or extrusion lamination can be used.
  • the thickness of the base film can be set to, for example, 150 ⁇ m or less, or 100 ⁇ m or less from the viewpoint of maintaining barrier properties and giving strength and the like to the entire laminate of the present invention, and is 20 ⁇ m or more, 30 ⁇ m, or 50 ⁇ m. This can be done.
  • the thickness of the base layer is, for example, 8 ⁇ m or more, 10 ⁇ m or more, or 12 ⁇ m or more. And can be 50 ⁇ m or less, or 25 ⁇ m or less.
  • the thickness of the barrier layer can be, for example, 7 ⁇ m or more, 10 ⁇ m or more, or 12 ⁇ m or more, and can be 50 ⁇ m or less, 45 ⁇ m or less, or 30 ⁇ m or less.
  • the thickness of the reinforcing layer can be, for example, 8 ⁇ m or more, 10 ⁇ m or more, or 12 ⁇ m or more, and can be 80 ⁇ m or less, 60 ⁇ m or less, 50 ⁇ m or less, or 25 ⁇ m or less.
  • the laminate for blister packs of the present invention may have a printing layer, an anchor coat layer for enhancing adhesion between two layers, and a primer layer between any two layers.
  • the blister pack of this invention has said laminated body for blister packs, and a cover material.
  • the first absorbent layer and the lid member of the blister pack laminate are at least partially bonded.
  • the pocket part for storing the contents such as tablets in the laminated body for blister pack
  • the medicine is stored in the pocket part
  • the lid material is adhered, and the contents are stored in the pocket part of the blister pack
  • a blister pack package can be produced.
  • the content of the blister pack of the present invention is not limited as long as it can be deteriorated by contact with the outside air, and examples thereof include foods, cosmetics, medical devices, electronic parts, and the like. Moreover, as a chemical
  • the lid member includes, for example, a thermoplastic resin layer and a metal layer.
  • a thermoplastic resin that can be used for the first absorption layer can be used.
  • an aluminum foil such as a pure aluminum foil or an aluminum alloy foil can be used.
  • the lid is in a form in which a thermoplastic resin layer is coated on an aluminum foil, and the thermoplastic resin layer of the lid and the layer (first absorption layer) to which the blister pack laminate is bonded are: From the viewpoint of improving adhesiveness, the same resin can be included.
  • an aluminum foil may be coated with an easy peel resin such as polyolefin polymer alloy, or an easy peel film may be laminated. In this case, the contents can be taken out by peeling at the bonding interface between the blister pack and the lid.
  • FIG. 1 is a schematic view of a blister pack 1.
  • the cover material 5 is bonded to the laminate 2 for blister pack formed by laminating the base film 3 and the absorbent film 4 in order, and the content is stored in the dome-shaped pocket portion formed in the laminate 2.
  • An object 100 is included.
  • an adhesive layer or an extrusion resin layer exists between the base film and the absorption film.
  • FIG. 2 is a schematic view of the layer structure of the blister pack 1 of the present invention.
  • the edge part in which the pocket part of the blister pack 1 is not formed is shown, and the base material layer 31, the barrier layer 32, the reinforcing layer 33, and the absorption film 4 of the base material film 3 are laminated in order.
  • a lid 5 is bonded to the blister pack laminate 2 formed as described above.
  • the absorbent film 4 is composed of a skin layer 41, a second absorbent layer 42, and a first absorbent layer 43
  • the lid member is composed of a thermoplastic resin layer 51 and a metal layer 52.
  • an inorganic absorbent zeolite (Union Showa Co., Ltd., zeolite 3A) and a thermoplastic resin EMAA (Mitsui-DuPont Polychemical Co., Ltd., Nukurell AN42115C) pellets are mixed into a twin-screw extruder (Ikegai Corporation, Using PCM70), pellets having a zeolite content of 53 wt% (45.6 vol%) for the second absorbent layer were obtained by kneading and pelletizing.
  • a twin-screw extruder Ikegai Corporation, Using PCM70
  • pellets of LLDPE manufactured by Prime Polymer Co., Ltd., Evolution SP2520
  • the first absorbent layer pellet and the second absorbent layer pellet are used to form a multilayer at 170 ° C.
  • an absorption film used in Comparative Examples 1 to 6 and Examples 7 to 10 was obtained using an inflation molding machine (Puraco Co., Ltd., TUL-600R).
  • the thickness of the skin layer was 10 ⁇ m.
  • These absorbent films include a base material layer, a barrier layer, and a reinforcing layer obtained by bonding a 25 ⁇ m nylon (Ny) film, a 40 ⁇ m aluminum (Al) foil, and a 60 ⁇ m polyvinyl chloride (PVC) film with an adhesive.
  • a base film manufactured by UACJ Co., Ltd., product name: AL / AL Yoki
  • was laminated using a dry laminator manufactured by Techno Smart Co., Ltd., INVEX pilot coater).
  • the adhesive the main agent (Mitsui Chemicals, Takelac (trademark) A1143), the curing agent (Mitsui Chemicals, Takenate (trademark) A3), and ethyl acetate were respectively 9: 1: 14.7.
  • a urethane-based adhesive contained in a weight ratio was used. The amount of adhesive applied was 5 g / m 2 . After the lamination, in order to cure the adhesive, it was aged by storing for 3 days in an environment of 40 ° C.
  • a pocket portion of the contents having a depth of 5.00 to 5.50 mm at room temperature was formed on the laminate thus obtained.
  • a high-speed hydraulic press (HYP505H) manufactured by Nippon Automatic Machine Co., Ltd. was used as the molding machine.
  • the plug material is ultra high molecular weight polyethylene resin (product name: Newlite (trademark) NL-W, Sakushin Kogyo Co., Ltd.) having a viscosity average molecular weight of 5.5 million, the plug diameter is 13 mm, and the molding speed is 200 mm / s. .
  • the test was performed 10 times for each depth in each example, and it was visually determined how many molding defects such as cracks, scratches, and dents occurred in the molded pocket.
  • the case where molding was possible without forming defects in all 10 times was marked as ⁇
  • the case where molding was possible in 8-9 times was marked as ⁇
  • the case where molding was possible in 5-7 times was marked as ⁇
  • the case where molding was possible only 4 times or less was marked as x.
  • the test results are shown in Table 1.
  • the measurement speed is 100 mm / min, the sliding piece is 200 g (40 cm 2 ), the sample is an ultra-high molecular weight PE film (viscosity average molecular weight 5.5 million, product name: Newlite film # 50W, resin used) : Newlite (trademark) NL-W Sakushin Kogyo Co., Ltd., arithmetic average roughness Ra: MD direction 0.067 ⁇ m, TD direction 0.073 ⁇ m).
  • the test results are shown in Table 1 together with the value of the static friction coefficient ⁇ S measured in the same manner.
  • Comparative Examples 1 to 6 it can be seen that many molding defects occur when a deep pocket portion of 5.50 mm is formed. Further, compared to Comparative Examples 1 and 2 in which the absorbent is not contained in the first absorbent layer, Comparative Examples 3 to 6 containing the absorbent tend to cause molding defects more easily. ing.
  • the first absorbent layer contains the inorganic absorbent in an appropriate amount, the inorganic absorbent particles when receiving force from the plug material. It is considered that the cushioning effect of the inorganic absorbent and the resin, which absorbs and disperses the stress in cooperation with the resin, appears more prominently than the decrease in the cushioning effect by the resin.
  • the absorption rate is remarkably improved as compared with the laminates of Comparative Examples 1 to 6, and it is necessary to create a deep pocket portion, and strongly influence the atmosphere. It can be seen that it is extremely effective when forming a blister pack for storing the contents to be received.
  • 3 and 4 show a comparison of the absorption rates of the laminates having the first absorption layer having a thickness of 10 ⁇ m and 20 ⁇ m, respectively.
  • the absorption rate and the absorption amount are improved as compared with the laminate of the comparative example.

Abstract

This provided laminate for use in a blister pack has an absorption function and is not prone to malformation even when pockets are formed to a fixed depth. This laminate for use in a blister pack comprises a substrate film (3) and an absorption film (4), wherein the aforementioned absorption film has the following layers: a skin layer (41) which includes a thermoplastic resin, contains less than 10 vol% of an inorganic absorbent, and is disposed to the substrate film side; and a heat-sealable first absorbent layer (43) which contains a thermoplastic resin and inorganic absorbent, and, measured in accordance with ISO 4287, has an arithmetical average roughness (Ra) of 0.700μm or greater on the surface opposite of the aforementioned skin layer.

Description

ブリスターパック用積層体、それを用いたブリスターパック、及びブリスターパック包装体Blister pack laminate, blister pack using the same, and blister pack package
　本発明は、ブリスターパック用積層体、その積層体を用いたブリスターパック、及びブリスターパック包装体に関する。特に、本発明は、大きな薬剤等を包装するために深さのあるポケット部を形成しても成形不良を発生させないブリスターパック用積層体、それを用いたブリスターパック、及びブリスターパック包装体に関する。 The present invention relates to a laminate for blister packs, a blister pack using the laminate, and a blister pack package. In particular, the present invention relates to a blister pack laminate that does not cause molding defects even when a pocket having a depth is formed to wrap a large drug or the like, a blister pack using the same, and a blister pack package.
　粉状の薬剤は、薄手の紙袋又はフィルム製袋等に封入されるが、錠剤又はカプセル剤等の薬剤は、ＰＴＰ（プレススルーパック）と呼ばれるブリスターパックに封入される。ブリスターパックに封入されている薬剤を指で押し込むことによって、シート状の蓋材を破り、そして薬剤を取り出すことができる。 Powdered drugs are enclosed in thin paper bags or film bags, while drugs such as tablets or capsules are enclosed in blister packs called PTP (press-through packs). By pushing the medicine enclosed in the blister pack with a finger, the sheet-like lid can be broken and the medicine can be taken out.
　薬剤は水分を吸収することで、薬効成分が変質することがある。そのため、従来は、ブリスターパックを封入する外装袋内にシリカゲル等の乾燥剤を封入していた。しかし、外装袋内に乾燥剤を投入する作業は手間がかかり、またこれを誤飲又は誤食される恐れもあった。また、外装袋の開封後は、ブリスターパック内を低湿度に保つことができず、薬剤の劣化が進行する問題もあった。さらに薬剤によっては、酸化分解しやすいもの、特有の臭気を発するもの等があるので、ブリスターパック内の酸素、臭気等のガスを吸収したいという要望もある。 ● Drugs may alter the medicinal properties by absorbing moisture. Therefore, conventionally, a desiccant such as silica gel has been enclosed in an outer bag enclosing a blister pack. However, the operation of putting the desiccant into the outer bag takes time and there is a risk of accidental ingestion or accidental eating. In addition, after opening the exterior bag, the inside of the blister pack cannot be kept at a low humidity, and there is a problem in that the deterioration of the drug progresses. Furthermore, some chemicals are easily oxidatively decomposed, and others emit a specific odor. Therefore, there is a demand for absorbing gas such as oxygen and odor in the blister pack.
　それに対し、特許文献１は、ブリスターパックの内部に吸着剤を有する吸着層を形成することによって、薬剤の長期安定性を向上させる技術を開示している。ここではまず、バリア層を含む基材フィルムと吸着層を含む吸収フィルムとの積層体に、ドーム状のポケット部分を形成する。そして、そのポケット部分に錠剤である薬剤を入れて、これを蓋材で封止している。この技術によれば、外装袋に乾燥剤等を同梱しなくても、乾燥状態の維持、酸化の防止、及び臭気の効率的な除去が可能となると考えられる。 On the other hand, Patent Document 1 discloses a technique for improving the long-term stability of a drug by forming an adsorption layer having an adsorbent inside a blister pack. Here, first, a dome-shaped pocket portion is formed in a laminate of a base film including a barrier layer and an absorbent film including an adsorption layer. And the chemical | medical agent which is a tablet is put into the pocket part, and this is sealed with the cover material. According to this technology, it is considered that it is possible to maintain a dry state, prevent oxidation, and efficiently remove odors without enclosing a desiccant or the like in the outer bag.
　また、薬剤の中には、紫外線に弱いものもあり、包装容器が透明であると、薬効成分が劣化するおそれがある。これに対して、特許文献１ではさらに、ブリスターパックの裏側の蓋材だけではなく、表側のブリスターパック用積層体にもアルミニウム層を形成する技術、いわゆるアルミブリスター包装を開示している。この技術によれば、ブリスターパックにアルミニウム層を形成するので薬剤は視認できないが、紫外線を遮断し、バリア性をさらに高めることができる。 Also, some medicines are vulnerable to ultraviolet rays, and if the packaging container is transparent, the medicinal properties may deteriorate. On the other hand, Patent Document 1 further discloses a technique for forming an aluminum layer not only on the cover material on the back side of the blister pack but also on the front blister pack laminate, so-called aluminum blister packaging. According to this technique, since the aluminum layer is formed on the blister pack, the drug cannot be visually recognized, but the ultraviolet ray can be blocked and the barrier property can be further enhanced.
　上記の２つの技術を単純に組み合わせた態様では、ブリスターパック用積層体にドーム状のポケットを成形する際に、ドームの天井部分が破れたり、裾の部分又は肩の部分に亀裂が発生したりする成形上の問題が発生するが、特許文献２はこれに対処するために、特定のポリマーを用いた補強層を、基材フィルムのアルミニウム層と吸収フィルムとの間に挿入している。 In a mode in which the above two technologies are simply combined, when forming a dome-shaped pocket in a blister pack laminate, the ceiling of the dome is torn or cracks are generated in the hem or shoulder. In order to cope with this problem, Patent Document 2 inserts a reinforcing layer using a specific polymer between the aluminum layer of the base film and the absorbent film.
国際公開第２００６／１１５２６４号International Publication No. 2006/115264 国際公開第２０１２／０２９３２３号International Publication No. 2012/029323
　特許文献１は、主吸着層を挟む２つの副吸着層（スキン層）に乾燥剤を含む吸収フィルム、及びバリア層を含む基材フィルムを有する積層体を開示している。このような態様では、積層体全体の吸収剤の含有量を高くすることができるが、副吸着層の表面が粗くなるため、基材層と副吸着層との間の接着が悪化し、成形深さを大きくしていくと、基材層と副吸着層とが一部剥離する、いわゆるラミ浮きが発生しやすくなることが分かった。ラミ浮きが発生した部分では、成形時に基材層と吸着層とが追従せず、成形時の負荷がその周りに集中し、積層体に裂けが発生しやすい。 Patent Document 1 discloses a laminate having an absorption film containing a desiccant in two sub-adsorption layers (skin layers) sandwiching a main adsorption layer and a base film containing a barrier layer. In such an embodiment, the content of the absorbent in the entire laminate can be increased, but since the surface of the sub-adsorption layer becomes rough, the adhesion between the base material layer and the sub-adsorption layer is deteriorated, and molding is performed. It has been found that as the depth is increased, so-called lami-floating is easily generated, in which the base material layer and the sub-adsorption layer are partially separated. In the portion where the lamellar float has occurred, the base material layer and the adsorption layer do not follow during molding, and the load during molding concentrates on the periphery, and the laminate tends to tear.
　さらに、特許文献１や特許文献２に記載の従来の構成では、成形機のプラグ形状又はポケット部分の成形深さによっては、依然としてポケットの肩の部分が裂けたり、ピンホールが発生したりすることが分かった。 Furthermore, in the conventional configuration described in Patent Document 1 and Patent Document 2, depending on the plug shape of the molding machine or the molding depth of the pocket portion, the shoulder portion of the pocket may still be torn or a pinhole may be generated. I understood.
　そこで、本発明は、大きな薬剤等の内容物を包装するためにポケットを一定の深さまで形成しても成形不良が発生しにくいブリスターパック用の積層体、それを用いたブリスターパック、及びブリスターパック包装体を提供することを目的とする。 Accordingly, the present invention provides a laminated body for blister packs that hardly causes molding defects even when pockets are formed to a certain depth for packaging contents such as large drugs, blister packs using the same, and blister packs An object is to provide a package.
　本発明者らは、以下の手段により、上記課題を解決できることを見出した。
　〈１〉　基材フィルム及び吸収フィルムを有するブリスターパック用の積層体であって、前記吸収フィルムが以下の層を有する、積層体：
　　熱可塑性樹脂を含み、かつ無機吸収剤の含有量が１０体積％未満である、前記基材フィルム側にあるスキン層；並びに
　　熱可塑性樹脂及び無機吸収剤を含み、かつＩＳＯ４２８７に準拠して測定した場合の前記スキン層と反対側の面の算術平均粗さＲａが、０．７００μｍ以上である、ヒートシール性の第１の吸収層。
　〈２〉　前記第１の吸収層の前記スキン層と反対側の面の算術平均粗さＲａが、１．３００μｍ以下である、上記〈１〉に記載の積層体。
　〈３〉　ＩＳＯ８２９５に準拠して測定した場合の超高分子量ポリエチレンとの前記第１の吸収層の前記スキン層と反対側の面の動摩擦係数μＤが、０．４２以下である、上記〈１〉又は〈２〉に記載の積層体。
　〈４〉　前記ヒートシール性の第１の吸収層が、２８．８体積％超の無機吸収剤を含む、上記〈１〉～〈３〉のいずれか一項に記載の積層体。
　〈５〉　７０体積％以下である無機吸収剤及び熱可塑性樹脂を含む第２の吸収層を、前記第１の吸収層と前記スキン層との間に含む、上記〈１〉～〈４〉のいずれか一項に記載の積層体。
　〈６〉　前記第１の吸収層及び第２の吸収層の無機吸収剤、並びに存在する場合には前記スキン層の無機吸収剤が、ゼオライト、アルミナ、酸化アルミニウム、ケイ酸マグネシウム、シリカゲル、酸化カルシウム、塩化カルシウム、硫酸カルシウム、硫酸マグネシウム、硫酸ナトリウム、炭酸カルシウム、酸化マグネシウム、酸化バリウム、五酸化二リン、過塩素酸マグネシウム、過マンガン酸カリウム、過マンガン酸ナトリウム、チオ硫酸ナトリウム、鉄粉、酸化第一鉄、第一鉄塩、塩化ナトリウム、臭化ナトリウム、ヨウ化ナトリウム、塩化カリウム、臭化カリウム、ヨウ化カリウム、塩化カルシウム、塩化マグネシウム、塩化バリウム、酸素欠乏酸化セリウム、亜硫酸塩、亜硫酸水素塩、亜ニチオン酸塩及びこれらの混合物からなる群よりそれぞれ独立して選択される、上記〈４〉又は〈５〉に記載の積層体。
　〈７〉　前記スキン層、第１の吸収層及び第２の吸収層の熱可塑性樹脂が、ポリオレフィン系樹脂、ポリ塩化ビニル、ポリスチレン、ポリカーボネート、ポリアミド、及びこれらの混合物からなる群よりそれぞれ独立して選択される、上記〈４〉～〈６〉のいずれか一項に記載の積層体。
　〈８〉　前記基材フィルムが、以下を含む、上記〈１〉～〈７〉のいずれか一項に記載の積層体：
　　熱可塑性樹脂を含む基材層、及び
　　前記スキン層側に位置し、かつ金属層を有するバリア層。
　〈９〉　上記〈１〉～〈８〉のいずれか一項に記載の積層体、並びに熱可塑性樹脂層及び金属層を有する蓋材を含み、前記積層体と前記蓋材とが少なくとも部分的に接着しており、かつ前記積層体にポケット部が形成されて前記積層体と前記蓋材との間に内容物が収納可能になっている、ブリスターパック。
　〈１０〉　上記〈９〉に記載のブリスターパックと、前記ポケット部に収納された内容物とを有するブリスターパック包装体。 The present inventors have found that the above problems can be solved by the following means.
<1> A laminate for a blister pack having a base film and an absorbent film, wherein the absorbent film has the following layers:
A skin layer on the base film side containing a thermoplastic resin and containing an inorganic absorbent of less than 10% by volume; and containing a thermoplastic resin and an inorganic absorbent and measured in accordance with ISO 4287 The heat-absorbing first absorption layer, wherein the arithmetic mean roughness Ra of the surface opposite to the skin layer is 0.700 μm or more.
<2> The laminate according to <1>, wherein the arithmetic average roughness Ra of the surface of the first absorbent layer on the side opposite to the skin layer is 1.300 μm or less.
<3> The above-mentioned <1>, wherein the dynamic friction coefficient μD of the surface of the first absorption layer opposite to the skin layer of the ultrahigh molecular weight polyethylene when measured according to ISO8295 is 0.42 or less. Or the laminated body as described in <2>.
<4> The laminate according to any one of <1> to <3>, wherein the heat-sealable first absorbent layer contains an inorganic absorbent in an amount of more than 28.8% by volume.
<5> The above-described <1> to <4>, comprising a second absorbent layer containing an inorganic absorbent and a thermoplastic resin that is 70% by volume or less between the first absorbent layer and the skin layer. The laminated body as described in any one.
<6> The inorganic absorbent of the first absorbent layer and the second absorbent layer, and when present, the inorganic absorbent of the skin layer is zeolite, alumina, aluminum oxide, magnesium silicate, silica gel, calcium oxide , Calcium chloride, calcium sulfate, magnesium sulfate, sodium sulfate, calcium carbonate, magnesium oxide, barium oxide, diphosphorus pentoxide, magnesium perchlorate, potassium permanganate, sodium permanganate, sodium thiosulfate, iron powder, oxidation Ferrous iron, ferrous salt, sodium chloride, sodium bromide, sodium iodide, potassium chloride, potassium bromide, potassium iodide, calcium chloride, magnesium chloride, barium chloride, oxygen-deficient cerium oxide, sulfite, hydrogen sulfite A group of salts, nitrite and mixtures thereof The laminate according to <4> or <5>, wherein each is independently selected.
<7> The thermoplastic resin of the skin layer, the first absorbent layer, and the second absorbent layer is each independently selected from the group consisting of polyolefin resin, polyvinyl chloride, polystyrene, polycarbonate, polyamide, and mixtures thereof. The laminate according to any one of <4> to <6>, which is selected.
<8> The laminate according to any one of <1> to <7>, wherein the base film includes:
A base material layer containing a thermoplastic resin, and a barrier layer located on the skin layer side and having a metal layer.
<9> The laminate according to any one of <1> to <8> above, and a lid member having a thermoplastic resin layer and a metal layer, wherein the laminate and the lid member are at least partially A blister pack that is bonded and has a pocket portion formed in the laminate so that the contents can be stored between the laminate and the lid.
<10> A blister pack package having the blister pack according to <9> above and the contents stored in the pocket portion.
　本発明の積層体によれば、吸収機能を持ち、かつ深いポケット部を有するブリスターパックを、成形不良の発生を抑えながら与えることができる。 According to the laminate of the present invention, a blister pack having an absorbing function and having a deep pocket portion can be provided while suppressing the occurrence of molding defects.
本発明の１つの実施態様に関するブリスターパック包装体の積層構造の概略を示す図である。It is a figure which shows the outline of the laminated structure of the blister pack package regarding one embodiment of this invention. 本発明の１つの実施態様に関するブリスターパック包装体の積層構造の詳細を示す図である。It is a figure which shows the detail of the laminated structure of the blister pack package regarding one embodiment of this invention. 厚さ１０μｍの第１の吸収層を有する積層体の吸収速度の比較を示す図である。It is a figure which shows the comparison of the absorption rate of the laminated body which has a 1st absorption layer of thickness 10 micrometers. 厚さ２０μｍの第１の吸収層を有する積層体の吸収速度の比較を示す図である。It is a figure which shows the comparison of the absorption rate of the laminated body which has a 1st absorption layer of thickness 20 micrometers.
〈ブリスターパック用積層体〉
　本発明のブリスターパック用の積層体は、基材フィルム及び吸収フィルムを含み、吸収フィルムは、次の層を有する：熱可塑性樹脂を含み、かつ無機吸収剤の含有量が１０体積％未満である、基材フィルム側にあるスキン層；並びに熱可塑性樹脂及び無機吸収剤を含み、かつＩＳＯ４２８７に準拠して測定した場合の前記スキン層と反対側の面の算術平均粗さＲａが、０．７００μｍ以上である、ヒートシール性の第１の吸収層。好ましくは、本発明の積層体は、スキン層と第１の吸収層との間に熱可塑性樹脂及び無機吸収剤を含む第２の吸収層をさらに有する。 <Laminated body for blister pack>
The laminate for a blister pack of the present invention includes a base film and an absorbent film, and the absorbent film has the following layers: a thermoplastic resin and an inorganic absorbent content of less than 10% by volume. A skin layer on the base film side; and an arithmetic average roughness Ra of the surface opposite to the skin layer when measured according to ISO 4287, including a thermoplastic resin and an inorganic absorbent, is 0.700 μm This is the first heat-sealable first absorption layer. Preferably, the laminate of the present invention further includes a second absorbent layer containing a thermoplastic resin and an inorganic absorbent between the skin layer and the first absorbent layer.
　本発明の積層体の厚さは、積層体の強度、コシ、ブリスターパック包装体に形成した際のプッシュスルー性、バリア性等の観点から、例えば２５０μｍ以下、２００μｍ以下、１５０μｍ以下、１００μｍ以下、９０μｍ以下、８５μｍ以下、又は８０μｍ以下とすることができ、また５０μｍ以上、６０μｍ、又は７０μｍ以上とすることができる。 The thickness of the laminate of the present invention is, for example, 250 μm or less, 200 μm or less, 150 μm or less, 100 μm or less from the viewpoint of the strength of the laminate, stiffness, push-through properties when formed into a blister pack package, barrier properties, etc. It can be 90 μm or less, 85 μm or less, or 80 μm or less, and can be 50 μm or more, 60 μm, or 70 μm or more.
（吸収フィルム）
　吸収フィルムは、無機吸収剤及び熱可塑性樹脂を含む第１の吸収層、無機吸収剤及び熱可塑性樹脂を含む第２の吸収層、並びに熱可塑性樹脂を含むスキン層を好ましくは含む。さらに好ましくは、第２の吸収層は、第１の吸収層よりも多くの無機吸収剤を含み、積層体に高い吸収性を付与する。そして、好ましくはヒートシール性の第１の吸収層を、多量の吸収剤の存在によってヒートシール性が損なわれた第２の吸収層に対して積層させることによって、積層体にヒートシール性を付与する。ただし、第２の吸収層の吸収剤の含有率を、第１の吸収層の含有率より低くすることもできる。 (Absorption film)
The absorbent film preferably includes a first absorbent layer containing an inorganic absorbent and a thermoplastic resin, a second absorbent layer containing an inorganic absorbent and a thermoplastic resin, and a skin layer containing a thermoplastic resin. More preferably, a 2nd absorption layer contains more inorganic absorbers than a 1st absorption layer, and provides high absorbency to a laminated body. And preferably, the heat-sealability is imparted to the laminate by laminating the heat-sealable first absorbent layer on the second absorbent layer whose heat-sealability is impaired by the presence of a large amount of absorbent. To do. However, the content rate of the absorbent in the second absorption layer can be made lower than the content rate of the first absorption layer.
　これらの層は、熱可塑性樹脂を含み、この樹脂としては、ポリオレフィン系樹脂が挙げられ、特に低密度ポリエチレン（ＬＤＰＥ）、直鎖状低密度ポリエチレン（ＬＬＤＰＥ）、中密度ポリエチレン（ＭＤＰＥ）、高密度ポリエチレン（ＨＤＰＥ）、メタロセン触媒を用いて重合したポリエチレン、プロピレンホモポリマー、プロピレン－エチレンブロック共重合体、プロピレン－エチレンランダム共重合体、メタロセン触媒を用いて重合したポリプロピレン、塩素化ポリプロピレン、ポリメチルペンテン、エチレン－アクリル酸共重合体（ＥＥＡ）、エチレン－メタクリル酸共重合体（ＥＭＡＡ）、エチレン－エチルアクリレート共重合体（ＥＥＡ）、エチレン－メチルアクリレート共重合体（ＥＭＡ）、エチレン－エチルアクリレート共重合体、エチレン－酢酸ビニル共重合体（ＥＶＡ）、アイオノマー、カルボン酸変性ポリエチレン、カルボン酸変性ポリプロピレン、カルボン酸変性エチレン－酢酸ビニル共重合体が挙げられ、さらに飽和ポリエステル、ポリ塩化ビニル（ＰＶＣ）、ポリスチレン、ポリカーボネート、ポリアミド、及びこれらの混合物も挙げられる。 These layers include a thermoplastic resin, and examples of the resin include polyolefin resins, and in particular, low density polyethylene (LDPE), linear low density polyethylene (LLDPE), medium density polyethylene (MDPE), and high density. Polyethylene (HDPE), polyethylene polymerized using metallocene catalyst, propylene homopolymer, propylene-ethylene block copolymer, propylene-ethylene random copolymer, polypropylene polymerized using metallocene catalyst, chlorinated polypropylene, polymethylpentene , Ethylene-acrylic acid copolymer (EEA), ethylene-methacrylic acid copolymer (EMAA), ethylene-ethyl acrylate copolymer (EEA), ethylene-methyl acrylate copolymer (EMA), ethylene-ethyl acrylate Polymer, ethylene-vinyl acetate copolymer (EVA), ionomer, carboxylic acid-modified polyethylene, carboxylic acid-modified polypropylene, carboxylic acid-modified ethylene-vinyl acetate copolymer, saturated polyester, polyvinyl chloride (PVC) , Polystyrene, polycarbonate, polyamide, and mixtures thereof.
　吸収フィルムは、無機吸収剤を含有するため、液体及び気体の少なくとも一方を吸収することができる。吸収対象としては、特に水分、有機及び無機のガス、例えば二酸化炭素、アンモニア、硫化水素、酸素、塩素、塩化水素等を挙げることができる。 Since the absorbent film contains an inorganic absorbent, it can absorb at least one of liquid and gas. Examples of the absorption target include moisture, organic and inorganic gases such as carbon dioxide, ammonia, hydrogen sulfide, oxygen, chlorine, hydrogen chloride and the like.
　第１の吸収層及び第２の吸収層に含まれる無機吸収剤としては、酸化カルシウム、塩化カルシウム、硫酸カルシウム、硫酸マグネシウム、硫酸ナトリウム、炭酸カルシウム、酸化マグネシウム、酸化バリウム、五酸化二リン、過塩素酸マグネシウム、過マンガン酸カリウム、過マンガン酸ナトリウム、チオ硫酸ナトリウム等の化学吸着剤、及びアルミナ、酸化アルミニウム、ケイ酸マグネシウム、生石灰、シリカゲル、無機の分子篩等の物理吸着剤を挙げることができる。無機の分子篩の例としては、限定されないが、アルミノケイ酸塩鉱物、クレー、多孔質ガラス、微細孔性活性炭、ゼオライト、活性炭、又は水等の小分子を拡散させることが可能な開口構造をもつ化合物を挙げることができる。 Examples of the inorganic absorbent contained in the first absorbent layer and the second absorbent layer include calcium oxide, calcium chloride, calcium sulfate, magnesium sulfate, sodium sulfate, calcium carbonate, magnesium oxide, barium oxide, diphosphorus pentoxide, excess Examples include chemical adsorbents such as magnesium chlorate, potassium permanganate, sodium permanganate, and sodium thiosulfate, and physical adsorbents such as alumina, aluminum oxide, magnesium silicate, quicklime, silica gel, and inorganic molecular sieves. . Examples of inorganic molecular sieves include, but are not limited to, aluminosilicate minerals, clays, porous glass, microporous activated carbon, zeolite, activated carbon, or compounds having an open structure capable of diffusing small molecules such as water. Can be mentioned.
　また、無機吸収剤として、鉄粉（例えば、還元鉄粉、噴霧鉄粉、活性鉄粉等）、酸化第一鉄、第一鉄塩等の鉄系酸素吸収剤、ハロゲン化金属（例えば、塩化ナトリウム、臭化ナトリウム、ヨウ化ナトリウム、塩化カリウム、臭化カリウム、ヨウ化カリウム、塩化カルシウム、塩化マグネシウム、塩化バリウム等）、酸素欠乏酸化セリウム、亜硫酸塩、亜硫酸水素塩、亜ニチオン酸塩等の脱酸素剤を挙げることもできる。 In addition, as an inorganic absorbent, iron powder (for example, reduced iron powder, sprayed iron powder, activated iron powder, etc.), iron-based oxygen absorbers such as ferrous oxide and ferrous salts, metal halides (for example, chloride) Sodium, sodium bromide, sodium iodide, potassium chloride, potassium bromide, potassium iodide, calcium chloride, magnesium chloride, barium chloride, etc.), oxygen-deficient cerium oxide, sulfite, bisulfite, nitrite, etc. Mention may also be made of oxygen scavengers.
　これらの中でも特に、無機吸収剤としてゼオライトが好ましい。ゼオライトとしては、天然ゼオライト、人工ゼオライト、合成ゼオライトを使用することができる。ゼオライトは、分子の大きさの違いによって物質を分離するのに用いられる多孔質の粒状物質であり、均一な細孔をもつ構造であって、細孔の空洞に入る小さな分子を吸収して一種の篩の作用を有するため、水（水蒸気）、有機ガス等を吸収することができる。合成ゼオライトの一例としてはモレキュラーシーブがあり、この中でも特に細孔（吸収口）径が０．３ｎｍ～１ｎｍのモレキュラーシーブを使用することができる。通常、細孔径が０．３ｎｍ、０．４ｎｍ、０．５ｎｍ、１ｎｍのモレキュラーシーブを、それぞれモレキュラーシーブ３Ａ、モレキュラーシーブ４Ａ、モレキュラーシーブ５Ａ、モレキュラーシーブ１３Ｘと称する。 Among these, zeolite is particularly preferable as the inorganic absorbent. As zeolite, natural zeolite, artificial zeolite, or synthetic zeolite can be used. Zeolite is a porous granular material used to separate substances according to the difference in molecular size, and has a structure with uniform pores. Therefore, water (water vapor), organic gas, etc. can be absorbed. An example of a synthetic zeolite is a molecular sieve. Among these, a molecular sieve having a pore (absorption port) diameter of 0.3 nm to 1 nm can be used. In general, molecular sieves having pore sizes of 0.3 nm, 0.4 nm, 0.5 nm, and 1 nm are referred to as molecular sieve 3A, molecular sieve 4A, molecular sieve 5A, and molecular sieve 13X, respectively.
　無機吸収剤の平均粒子径（レーザー回折・散乱法によって求めた粒度分布における積算値５０％での粒径）は、特に限定されるものではないが、例えば体積基準メジアン径（ｄ５０）が１００ｎｍ以上、５００ｎｍ以上、１μｍ以上、又は５μｍ以上であってもよく、又は１００μｍ以下、５０μｍ以下、３０μｍ以下、又は１５μｍ以下のものであってもよい。本発明では、被吸収物質、内容物の性質、第１の吸収層の表面粗さ、目的の吸収速度等に合わせて、上記の無機吸収剤を適宜使い分けることができる。 The average particle size of the inorganic absorbent (the particle size at an integrated value of 50% in the particle size distribution determined by the laser diffraction / scattering method) is not particularly limited. For example, the volume-based median diameter (d50) is 100 nm or more. 500 nm or more, 1 μm or more, or 5 μm or more, or 100 μm or less, 50 μm or less, 30 μm or less, or 15 μm or less. In the present invention, the above-mentioned inorganic absorbent can be properly used according to the material to be absorbed, the properties of the contents, the surface roughness of the first absorbent layer, the intended absorption rate, and the like.
　第１の吸収層及びスキン層を含む吸収フィルムは、多層インフレーション法によって製造することができる。これは複数の押出機によって同時に複数の樹脂をチューブ状に押出して、この中に空気を送って膨らませて、多層フィルムを製造する方法である。このようにして、第１の吸収層とスキン層とを同時に成形して、吸収フィルムを得ることができる。第１の吸収層及びスキン層を、インフレーション法、Ｔダイ法、カレンダー法、キャスティング法、プレス成形、押出成形又は射出成形することによりフィルム状又はシート状に形成し、それらをラミネートすることによって、吸収フィルムを得てもよい。 The absorption film including the first absorption layer and the skin layer can be manufactured by a multilayer inflation method. This is a method for producing a multilayer film by extruding a plurality of resins into a tube shape at the same time by a plurality of extruders and sending the air into the tubes to inflate them. Thus, an absorption film can be obtained by simultaneously molding the first absorption layer and the skin layer. By forming the first absorbent layer and the skin layer into a film or sheet by inflation, T-die, calender, casting, press molding, extrusion or injection molding, and laminating them, An absorption film may be obtained.
　また、第１の吸収層、第２の吸収層及びスキン層を含む吸収フィルムも、多層インフレーション法によって製造することができる。第２の吸収層を、インフレーション法、Ｔダイ法、カレンダー法、キャスティング法、プレス成形、押出成形又は射出成形することによりフィルム状又はシート状に形成し、スキン層及び第１の吸収層をそれぞれ公知の方法でフィルム化した後に、第２の吸収層を挟んでラミネートすることによって、この３層の吸収フィルムを製造することもできる。 Further, an absorption film including the first absorption layer, the second absorption layer, and the skin layer can also be produced by a multilayer inflation method. The second absorbent layer is formed into a film or sheet by performing inflation method, T-die method, calendar method, casting method, press molding, extrusion molding or injection molding, and the skin layer and the first absorbent layer are formed respectively. This three-layer absorption film can also be produced by forming a film by a known method and laminating the second absorption layer.
　第１の吸収層及び随意に第２の吸収層をインフレーション法によって製造する前には、好ましくは熱可塑性樹脂と無機吸収剤とを二軸混練機で加熱混練した後に、ペレット状に加工することで、これらの層用の樹脂組成物（ペレット）を作製する。さらに、上記ペレットと、熱可塑性樹脂のペレットとをドライブレンドすることで、無機吸収剤の含有率を希釈調整してもよい。そして、第１の吸収層及び随意に第２の吸収層用のペレットと、スキン層用の熱可塑性樹脂のペレットを用いて、インフレーション法により多層製膜を行うことで吸収フィルムを製造する。第２の吸収層をインフレーション法により製造した後、別途製造したスキン層及び第１の吸収層を熱圧着等によってラミネートして、吸収フィルムを得てもよい。 Before producing the first absorbent layer and optionally the second absorbent layer by the inflation method, preferably, the thermoplastic resin and the inorganic absorbent are heat-kneaded in a biaxial kneader and then processed into a pellet. Thus, a resin composition (pellet) for these layers is prepared. Further, the content of the inorganic absorbent may be adjusted by dry blending the pellets and the thermoplastic resin pellets. Then, using the first absorbent layer and optionally the pellets for the second absorbent layer and the pellets of the thermoplastic resin for the skin layer, an absorbent film is produced by forming a multilayer film by an inflation method. After the second absorption layer is manufactured by an inflation method, the separately manufactured skin layer and the first absorption layer may be laminated by thermocompression bonding or the like to obtain an absorption film.
　吸収フィルムをＴダイ法によって製造する場合にも、事前に無機吸収剤と熱可塑性樹脂を含むペレットを作製してから、フィルムを成形することができる。この際に、第１の吸収層の一方の面にスキン層を共押出して吸収フィルムを得てもよく、第２の吸収層を含む場合には、必要に応じて第２の吸収層を共押出して、又は別途製造した第２の吸収層となるフィルムを熱圧着等によってラミネートして、吸収フィルムを得てもよい。 Even when the absorbent film is manufactured by the T-die method, the film can be formed after preparing pellets containing an inorganic absorbent and a thermoplastic resin in advance. At this time, a skin layer may be co-extruded on one surface of the first absorbent layer to obtain an absorbent film. When the second absorbent layer is included, the second absorbent layer may be co-extruded as necessary. An absorption film may be obtained by extruding or laminating a film to be a second absorption layer separately manufactured by thermocompression bonding or the like.
　吸収フィルムの厚さは、例えば２００μｍ以下、１５０μｍ以下、１００μｍ以下、又は８０μｍ以下であり、また３０μｍ以上、４０μｍ、又は５０μｍ以上である。特に、１００μｍ以下であれば、プッシュスルー性が良好なので、好ましい。 The thickness of the absorption film is, for example, 200 μm or less, 150 μm or less, 100 μm or less, or 80 μm or less, and 30 μm or more, 40 μm, or 50 μm or more. In particular, the thickness of 100 μm or less is preferable because the push-through property is good.
（吸収フィルム－第１の吸収層）
　第１の吸収層に無機吸収剤を含有させることで、本発明の積層体の一方の表面に適切な表面粗さを与える。本発明においては、流れ方向（ＭＤ）及び幅方向（ＴＤ）の両方向で、ＩＳＯ４２８７に準拠して測定した場合、スキン層と反対側の面の第１の吸収層の算術平均粗さＲａが、０．７００μｍ以上である。 (Absorbent film-first absorbent layer)
By including an inorganic absorbent in the first absorbent layer, an appropriate surface roughness is given to one surface of the laminate of the present invention. In the present invention, when measured according to ISO 4287 in both the flow direction (MD) and the width direction (TD), the arithmetic average roughness Ra of the first absorbent layer on the surface opposite to the skin layer is It is 0.700 μm or more.
　本発明のブリスターパック用の積層体を用いて、ブリスターパックを作製する際には、積層体にブリスターパックのポケット部となるドーム状部分を形成する。その際のドーム状部分の成型方法としては、平板式空圧成形法、プラグアシスト圧空成形法、ドラム式真空成型法、プラグ成形法等が挙げられる。この中でも特に、粘度平均分子量１００万以上の超高分子量ポリエチレン樹脂の先端部が丸い円柱状の棒（プラグ材）を用いたプラグ成形法が、ポケットを形成するためには好ましい。しかし、この方法において深いポケットを形成しようとすると、ドーム状のポケット部の肩の部分又はすその部分に亀裂が発生することがある。 When producing a blister pack using the laminate for a blister pack of the present invention, a dome-shaped portion that becomes a pocket portion of the blister pack is formed in the laminate. Examples of the method for forming the dome-shaped part include a flat plate air forming method, a plug assist pressure forming method, a drum vacuum forming method, a plug forming method, and the like. Among these, a plug molding method using a cylindrical rod (plug material) having a round tip at a viscosity-average molecular weight of 1,000,000 or more is preferable for forming a pocket. However, if a deep pocket is formed by this method, a crack may occur in the shoulder portion or the skirt portion of the dome-shaped pocket portion.
　本発明者らは、プラグ材が接触する積層体の吸収フィルムの第１の吸収層の表面粗さが小さい場合には、ポケット部を成形する際に、ブリスターパック用積層体に高い確率で亀裂が発生することを見出した。すなわち、第１の吸収層の表面粗さが小さい場合、プラグ材と第１の吸収層との接触部分で摩擦が生じ、その接触部分のみが大きく引き伸ばされ、その箇所で積層体に大きな引っ張り応力が発生し、亀裂が発生すると考えられる。 When the surface roughness of the first absorbent layer of the laminate absorbent film in contact with the plug material is small, the inventors crack the blister pack laminate with a high probability when forming the pocket portion. Found that occurs. That is, when the surface roughness of the first absorbent layer is small, friction occurs at the contact portion between the plug material and the first absorbent layer, and only the contact portion is greatly stretched, and a large tensile stress is applied to the laminate at that location. It is thought that cracks occur.
　そこで本発明者らは、吸収フィルムの第１の吸収層の表面粗さを大きくしてプラグ材が滑りやすくすることによって、プラグ材を第１の吸収層に押し込めた際に、押し込み面全体にできるだけ均一にひずみを与えるようにし、上記の本発明に至った。 Therefore, the present inventors increase the surface roughness of the first absorption layer of the absorption film to make the plug material slippery, so that when the plug material is pushed into the first absorption layer, the entire pushing surface is formed. The present invention has been achieved by applying strain as uniformly as possible.
　一方で、第１の吸収層は蓋材と溶着される層であるため、ヒートシール性を有することが好ましく、製膜性観点から、高すぎる表面粗さは適切ではない場合がある。その観点から、本発明の第１の吸収層は、第１の吸収層のスキン層と反対側の面の算術平均粗さＲａは、流れ方向（ＭＤ）及び幅方向（ＴＤ）の両方向で、例えば２．０００μｍ以下、１．５００μｍ以下、１．３００μｍ以下、又は１．２００μｍ以下とすることができる。 On the other hand, since the first absorption layer is a layer welded to the lid material, it preferably has heat sealability, and a surface roughness that is too high may not be appropriate from the viewpoint of film formation. From that point of view, the first absorbent layer of the present invention has an arithmetic mean roughness Ra of the surface of the first absorbent layer opposite to the skin layer in both the flow direction (MD) and the width direction (TD). For example, it can be 2.000 μm or less, 1.500 μm or less, 1.300 μm or less, or 1.200 μm or less.
　同様に、第１の吸収層のスキン層と反対側の面は、動摩擦係数が低いことが好ましい。本発明においては、ＩＳＯ８２９５に準拠して測定した場合の超高分子量ポリエチレンとの、スキン層と反対側の面の第１の吸収層の動摩擦係数μＤは、０．４２以下である。 Similarly, the surface of the first absorbent layer opposite to the skin layer preferably has a low coefficient of dynamic friction. In the present invention, the dynamic friction coefficient μD of the first absorbent layer on the surface opposite to the skin layer with ultrahigh molecular weight polyethylene when measured according to ISO8295 is 0.42 or less.
　ここで、超高分子量ポリエチレンとは、ＪＩＳ　Ｋ７３６７－３：１９９９に基づいて測定した粘度平均分子量が１００万以上のポリエチレンであり、特に分子量５５０万の超高分子量ポリエチレン樹脂（製品名：ニューライト（商標）ＮＬ－Ｗ、作新工業株式会社）である。これは、ブリスターパックのポケット部分を成形する際に用いるプラグ材に通常用いられる超高分子量ポリエチレンと同じとするためである。動摩擦係数が小さい場合には、ポケット部形成中にプラグ材と第１の吸収層との滑りが良くなり、プラグ材と第１の吸収層との接触部分の局所的なひずみが発生しにくくなる。 Here, the ultra high molecular weight polyethylene is a polyethylene having a viscosity average molecular weight of 1 million or more measured based on JIS K7367-3: 1999, and particularly an ultra high molecular weight polyethylene resin having a molecular weight of 5.5 million (product name: Neulite ( Trademark) NL-W, Sakushin Kogyo Co., Ltd.). This is because it is the same as the ultrahigh molecular weight polyethylene usually used for the plug material used when molding the pocket portion of the blister pack. When the dynamic friction coefficient is small, sliding between the plug material and the first absorbent layer is improved during the formation of the pocket portion, and local strain at the contact portion between the plug material and the first absorbent layer is less likely to occur. .
　上記の表面粗さ及び随意に動摩擦係数を、第１の吸収層への無機吸収剤の添加だけではなく、第１の吸収層への他の物質の添加、表面処理、加工等によって得てもよい。 The surface roughness and optionally the dynamic friction coefficient can be obtained not only by adding an inorganic absorbent to the first absorbent layer, but also by adding other substances to the first absorbent layer, surface treatment, processing, etc. Good.
　しかし、上記の表面粗さ及び／又は動摩擦係数は、第１の吸収層に適切な無機吸収剤が適切な量で含まれることによって与えられていることが好ましい。これにより、高い吸収能力と、ブリスターパックの成形不良の抑制とを両立させることができる。 However, it is preferable that the surface roughness and / or the dynamic friction coefficient is given by including an appropriate inorganic absorbent in an appropriate amount in the first absorption layer. Thereby, high absorption capability and suppression of the molding defect of a blister pack can be made to make compatible.
　具体的には、第１の吸収層は、製膜性およびヒートシール性を損なわない限り、無機吸収剤を多く含むことができ、例えば第１の吸収層中に、２８．８体積％超、３０体積％以上、３３体積％以上、３５体積％以上、３８体積％以上、又は４０体積％以上とすることができる。第１の吸収層は、高いヒートシール性を有するように、例えば７０．０体積％未満、６５体積％以下、６０体積％以下、５５体積％以下、又は５０体積％以下の範囲で無機吸収剤を含んでもよい。 Specifically, the first absorbent layer can contain a large amount of an inorganic absorbent as long as the film-forming property and the heat sealability are not impaired. For example, the first absorbent layer contains more than 28.8% by volume, It can be 30 volume% or more, 33 volume% or more, 35 volume% or more, 38 volume% or more, or 40 volume% or more. The first absorbent layer has an inorganic absorbent in a range of, for example, less than 70.0% by volume, 65% by volume or less, 60% by volume or less, 55% by volume or less, or 50% by volume or less so as to have high heat sealability. May be included.
　第１の吸収層に無機吸収剤を適切な量で添加すると、無機吸収剤が表面に存在することで表面粗さが高くなり、プラグ材との接触面積が小さくなると考えられる。接触面積が小さくなると、第１の吸収層とプラグ材との間での局所的な滑りが起こりやすくなって、押し込み面全体に均一にひずみを与えることができると考えられる。 It is considered that when an appropriate amount of inorganic absorbent is added to the first absorbent layer, the surface roughness is increased due to the presence of the inorganic absorbent on the surface, and the contact area with the plug material is reduced. When the contact area becomes small, local slip is likely to occur between the first absorption layer and the plug material, and it is considered that the entire pushing surface can be uniformly strained.
　さらに、第１の吸収層にプラグ材を押し込んでいくと、第１の吸収層の熱可塑性樹脂の柔軟性に由来するクッション効果が働くと推測されるが、第１の吸収層に無機吸収剤が適切な量で含有されていると、第１の吸収層の熱可塑性樹脂によるクッションの効果だけではなく、応力を分散する無機吸収剤の粒子由来のクッション性が現れると考えられる。すなわち、第１の吸収層表面の無機吸収剤による凸部が、プラグ材から力を受けた場合に、熱可塑性樹脂に無機吸収剤粒子が沈み込むことで応力を吸収し、これが徐々に分散していくという現象が考えられる。 Furthermore, when the plug material is pushed into the first absorbent layer, it is presumed that a cushion effect derived from the flexibility of the thermoplastic resin of the first absorbent layer works, but the inorganic absorbent is applied to the first absorbent layer. If it is contained in an appropriate amount, it is considered that not only the cushioning effect of the thermoplastic resin of the first absorbent layer but also the cushioning property derived from the particles of the inorganic absorbent that disperses the stress appears. That is, when the convex part by the inorganic absorbent on the surface of the first absorbent layer receives a force from the plug material, the inorganic absorbent particles sink into the thermoplastic resin to absorb the stress, and this gradually disperses. The phenomenon of going on can be considered.
　なお、層中に含まれる無機吸収剤の体積％を計算する場合に、無機吸収剤の比重が不明確な場合には、その層の比重を測定によって求め、その測定値と、無機吸収剤及び熱可塑性樹脂の添加重量と、熱可塑性樹脂の比重から無機吸収剤の体積％を求めてもよい。例えば、無機吸収剤５０ｇと、比重０．９ｇ／ｃｍ３の熱可塑性樹脂５０ｇとを用いて成形した層の比重が１．１ｇ／ｃｍ３であった場合には、その層に含まれている無機吸収剤は、比重が１．４１ｇ／ｃｍ３と計算することができ、その層中で３８．９体積％存在しているといえる。 In addition, when calculating the volume% of the inorganic absorbent contained in the layer, if the specific gravity of the inorganic absorbent is unclear, the specific gravity of the layer is obtained by measurement, the measured value, the inorganic absorbent and The volume% of the inorganic absorbent may be determined from the added weight of the thermoplastic resin and the specific gravity of the thermoplastic resin. For example, when the specific gravity of a layer formed using 50 g of an inorganic absorbent and 50 g of a thermoplastic resin having a specific gravity of 0.9 g / cm 3 is 1.1 g / cm 3 , it is included in the layer. The inorganic absorbent can be calculated to have a specific gravity of 1.41 g / cm 3, and it can be said that 38.9% by volume is present in the layer.
　第１の吸収層の厚さは、例えば３０μｍ以下、２０μｍ以下、又は１５μｍ以下であり、また５μｍ以上、８μｍ、又は１０μｍ以上である。 The thickness of the first absorption layer is, for example, 30 μm or less, 20 μm or less, or 15 μm or less, and 5 μm or more, 8 μm, or 10 μm or more.
（吸収フィルム－第２の吸収層）
　第２の吸収層は、第１の吸収層の無機吸収剤の含有率以下とすることもできるが、第１の吸収層の無機吸収剤の含有率以上とすることが好ましい。被吸収物質の吸収量及びフィルム化安定性の観点から、無機吸収剤は、例えば第２の吸収層中に５体積％以上、１０体積％以上、又は２０体積％以上とすることができ、また７０体積％以下、６０体積％以下、又は５０体積％以下の範囲とすることができる。 (Absorbing film-second absorbing layer)
Although the 2nd absorption layer can also be made into below the content rate of the inorganic absorber of a 1st absorption layer, it is preferable to make it into more than the content rate of the inorganic absorber of a 1st absorption layer. From the viewpoint of the absorption amount of the substance to be absorbed and the film-forming stability, the inorganic absorbent can be, for example, 5% by volume or more, 10% by volume or more, or 20% by volume or more in the second absorption layer. It can be made into the range of 70 volume% or less, 60 volume% or less, or 50 volume% or less.
　第２の吸収層の厚さは、例えば１０μｍ以上、２０μｍ以上、又は３０μｍ以上であり、１８０μｍ以下、１５０μｍ以下、１００μｍ以下、又は８０μｍ以下、又は５０μｍ以下である。特に、８０μｍ以下であれば、プッシュスルー性が良好であるため、好ましい。 The thickness of the second absorption layer is, for example, 10 μm or more, 20 μm or more, or 30 μm or more, and is 180 μm or less, 150 μm or less, 100 μm or less, or 80 μm or less, or 50 μm or less. In particular, the thickness is preferably 80 μm or less because the push-through property is good.
（吸収フィルム－スキン層）
　スキン層には、スキン層が隣接する層、例えば基材フィルムの基材層、バリア層、補強層等との貼り合わせの観点から、好ましくは無機吸収剤を含まない。スキン層が無機吸収剤を多く含むと、スキン層の表面が粗くなり、隣接する層とスキン層とが剥離する、いわゆるラミ浮きが発生しやすくなるため、スキン層が無機吸収剤を含む場合であっても、その層中で１０体積％、７体積％、５体積％、３体積％、又は１体積％以下となることが好ましい。１０体積％以下であれば、スキン層の表面があまり粗くなることがないため、隣接する層との間にラミ浮きが発生することはほとんどなく、７体積％以下の場合には特にその効果が高い。 (Absorbing film-skin layer)
The skin layer preferably does not contain an inorganic absorbent from the viewpoint of bonding with a layer adjacent to the skin layer, for example, a base material layer, a barrier layer, a reinforcing layer, or the like of the base film. If the skin layer contains a large amount of an inorganic absorbent, the surface of the skin layer becomes rough, and the adjacent layer and the skin layer tend to peel off, so-called lami-floating easily occurs. Even if it exists, it is preferable that it becomes 10 volume%, 7 volume%, 5 volume%, 3 volume%, or 1 volume% or less in the layer. If the volume is 10% by volume or less, the surface of the skin layer is not so rough, so that there is almost no occurrence of lami-floating between adjacent layers. high.
　スキン層の厚さは、例えば３０μｍ以下、２０μｍ以下、又は１５μｍ以下であり、また５μｍ以上、８μｍ以上、又は１０μｍ以上である。 The thickness of the skin layer is, for example, 30 μm or less, 20 μm or less, or 15 μm or less, and 5 μm or more, 8 μm or more, or 10 μm or more.
（基材フィルム）
　基材フィルムは、吸収フィルムを外部環境と隔離し、積層体全体に適切なコシ、強度等を与える。基材フィルムは、基材層の他、金属層を有するバリア層を含んでもよく、さらに補強層を含んでもよい。 (Base film)
The base film isolates the absorbent film from the external environment, and gives appropriate stiffness and strength to the entire laminate. The base film may include a barrier layer having a metal layer in addition to the base layer, and may further include a reinforcing layer.
　基材層は、熱可塑性樹脂を含み、その熱可塑性樹脂としては、例えばポリオレフィン系樹脂、ポリ塩化ビニル、ポリ塩化ビニリデン（ＰＶＤＣ）、ポリクロロトリフルオロエチレン、ポリテトラフルオロエチレン、飽和又は不飽和ポリエステル（例えば、ポリエチレンテレフタレート（ＰＥＴ）、ポリブチレンテレフタレート）、ポリアミド（例えば、ナイロン（登録商標）、ナイロン６、ナイロンＭＸＤ６）、ポリアクリロニトリル（ＰＡＮ）を挙げることができ、これらのフィルムを単層又は複数層組合せて基材層として用いることができる。 The base material layer includes a thermoplastic resin. Examples of the thermoplastic resin include polyolefin resins, polyvinyl chloride, polyvinylidene chloride (PVDC), polychlorotrifluoroethylene, polytetrafluoroethylene, and saturated or unsaturated polyester. (For example, polyethylene terephthalate (PET), polybutylene terephthalate), polyamide (for example, nylon (registered trademark), nylon 6, nylon MXD6), polyacrylonitrile (PAN), and a single layer or a plurality of these films The layers can be combined and used as a base material layer.
　バリア層は、金属層を有し、特に純アルミニウム（Ａｌ）箔、アルミニウム合金箔を含む層であってもよい。その他、バリア層として、金属、半金属若しくはそれらの酸化物の蒸着層又はハロゲン化ポリマー層を少なくとも有する熱可塑性樹脂フィルムを、単独で又は上記のフィルムと組み合わせて用いることもできる。具体的には、金属、半金属又はそれらの酸化物の蒸着層としては、アルミニウム蒸着膜、シリカ蒸着膜、アルミナ蒸着膜、シリカ・アルミナ二元蒸着膜等を挙げることができ、ハロゲン化ポリマー層としては、ポリ塩化ビニリデンコーティング膜、ポリフッ化ビニリデンコーティング膜等を挙げることができる。これらを堆積させる樹脂フィルムとして、ポリオレフィン系樹脂（特に、延伸又は無延伸ポリプロピレン）、ポリ塩化ビニル、飽和ポリエステル（例えば、ポリエチレンテレフタレート（ＰＥＴ）、ポリブチレンテレフタレート）、ポリアミド（例えば、ナイロン（登録商標）、ナイロン６、ナイロンＭＸＤ６）を挙げることができる。 The barrier layer has a metal layer, and may be a layer including a pure aluminum (Al) foil or an aluminum alloy foil. In addition, as the barrier layer, a thermoplastic resin film having at least a vapor-deposited layer of metal, metalloid or their oxide or a halogenated polymer layer can be used alone or in combination with the above film. Specifically, examples of the vapor deposition layer of metal, metalloid or oxide thereof include aluminum vapor deposition film, silica vapor deposition film, alumina vapor deposition film, silica / alumina binary vapor deposition film, and the like. Halogenated polymer layer Examples thereof include a polyvinylidene chloride coating film and a polyvinylidene fluoride coating film. As resin films for depositing these, polyolefin resins (particularly stretched or unstretched polypropylene), polyvinyl chloride, saturated polyesters (for example, polyethylene terephthalate (PET), polybutylene terephthalate), polyamides (for example, nylon (registered trademark)) , Nylon 6 and nylon MXD6).
　基材層として用いることができるフィルムを、補強層として用いることもできる。特に、ポリアミド、ポリエチレンテレフタレート、及びポリ塩化ビニルが好ましい。 A film that can be used as a base material layer can also be used as a reinforcing layer. In particular, polyamide, polyethylene terephthalate, and polyvinyl chloride are preferable.
　例えば基材フィルムは、基材層であるＰＥＴフィルムとバリア層であるＡｌ箔との積層フィルムとすることができ、この場合ＰＥＴフィルムを基材層として最外層とし、Ａｌ箔をバリア層として吸収フィルム側に位置させる。さらに基材フィルムは、基材層であるＰＥＴフィルムを最外層とし、バリア層であるＡｌ箔をＰＥＴフィルムの吸収フィルム側に位置させ、さらにＡｌ箔と吸収フィルムとの間に、補強層となるポリアミドフィルムを有してもよい。 For example, the base film can be a laminated film of a PET film as a base layer and an Al foil as a barrier layer. In this case, the PET film is used as the base layer and the Al foil is absorbed as a barrier layer. Position it on the film side. Furthermore, the base film is the outermost layer of the PET film as the base layer, the Al foil as the barrier layer is positioned on the absorption film side of the PET film, and becomes a reinforcing layer between the Al foil and the absorption film. You may have a polyamide film.
　基材フィルムが積層フィルムである場合、そのラミネートの方法としては、ドライラミネート、押出ラミネートなど、公知のラミネート方法を用いることができる。 When the substrate film is a laminated film, a known lamination method such as dry lamination or extrusion lamination can be used as the lamination method.
　基材フィルムと吸収フィルムとのラミネートの方法もそれと同様であり、ドライラミネート、押出ラミネートなど、公知のラミネート方法を用いることができる。 The method for laminating the base film and the absorbent film is the same as that, and a known laminating method such as dry lamination or extrusion lamination can be used.
　基材フィルムの厚さは、バリア性を維持し、かつ本発明の積層体全体に強度等を与える観点から、例えば１５０μｍ以下、又は１００μｍ以下とすることができ、また２０μｍ以上、３０μｍ、又は５０μｍ以上とすることができる。 The thickness of the base film can be set to, for example, 150 μm or less, or 100 μm or less from the viewpoint of maintaining barrier properties and giving strength and the like to the entire laminate of the present invention, and is 20 μm or more, 30 μm, or 50 μm. This can be done.
　例えば、基材フィルムを、基材層（例えば、延伸樹脂フィルム）とバリア層と補強層とから構成する場合、基材層の厚さは、例えば８μｍ以上、１０μｍ以上、又は１２μｍ以上とすることができ、５０μｍ以下、又は２５μｍ以下とすることができる。そしてバリア層の厚さは、例えば７μｍ以上、１０μｍ以上、又は１２μｍ以上とすることができ、５０μｍ以下、４５μｍ以下、又は３０μｍ以下とすることができる。補強層の厚さは、例えば８μｍ以上、１０μｍ以上、又は１２μｍ以上とすることができ、８０μｍ以下、６０μｍ以下、５０μｍ以下、又は２５μ以下とすることができる。 For example, when the base film is composed of a base layer (for example, a stretched resin film), a barrier layer, and a reinforcing layer, the thickness of the base layer is, for example, 8 μm or more, 10 μm or more, or 12 μm or more. And can be 50 μm or less, or 25 μm or less. The thickness of the barrier layer can be, for example, 7 μm or more, 10 μm or more, or 12 μm or more, and can be 50 μm or less, 45 μm or less, or 30 μm or less. The thickness of the reinforcing layer can be, for example, 8 μm or more, 10 μm or more, or 12 μm or more, and can be 80 μm or less, 60 μm or less, 50 μm or less, or 25 μm or less.
　本発明のブリスターパック用積層体は、任意の２つの層の間に、印刷層や、２層間の接着を高めるためのアンカーコート層、プライマー層を有してもよい。 The laminate for blister packs of the present invention may have a printing layer, an anchor coat layer for enhancing adhesion between two layers, and a primer layer between any two layers.
〈ブリスターパック、及びブリスターパック包装体〉
　本発明のブリスターパックは、上記のブリスターパック用積層体、及び蓋材を有する。ブリスターパック用積層体の第１の吸収層と蓋材は、少なくとも部分的に接着する。ブリスターパック用積層体に、錠剤等の内容物を収納するためのポケット部の成形をした後に薬剤をポケット部に収容し、蓋材を接着させて、ブリスターパックのポケット部に内容物を収納したブリスターパック包装体を作製することができる。 <Blister pack and blister pack package>
The blister pack of this invention has said laminated body for blister packs, and a cover material. The first absorbent layer and the lid member of the blister pack laminate are at least partially bonded. After forming the pocket part for storing the contents such as tablets in the laminated body for blister pack, the medicine is stored in the pocket part, the lid material is adhered, and the contents are stored in the pocket part of the blister pack A blister pack package can be produced.
　本発明のブリスターパックの内容物としては、外気との接触によって劣化しうる物であれば限定されるものではなく、薬剤の他、食品、化粧品、医療機器、電子部品等を挙げることができる。また、薬剤としては、医薬品製剤の他、洗浄剤、農薬等を含む。 The content of the blister pack of the present invention is not limited as long as it can be deteriorated by contact with the outside air, and examples thereof include foods, cosmetics, medical devices, electronic parts, and the like. Moreover, as a chemical | medical agent, a cleaning agent, an agrochemical, etc. are included besides a pharmaceutical formulation.
（蓋材）
　蓋材は、例えば熱可塑性樹脂層と金属層とを含む。その樹脂層としては、第１の吸収層に使用できる熱可塑性樹脂を用いることができる。また、金属層としては、純アルミニウム箔、アルミニウム合金箔等のアルミニウム箔を用いることができる。好ましくは、蓋材は、アルミニウム箔に熱可塑性樹脂層がコーティングされた形態であり、蓋材の熱可塑性樹脂層と、ブリスターパック用積層体の接着する層（第１の吸収層）とは、接着性を高める観点から、同じ樹脂を含むことができる。また、アルミニウム箔にポリオレフィン系ポリマーアロイ等のイージーピール性樹脂がコーティング、またはイージーピールフィルムが積層された形態とすることもできる。この場合、ブリスターパックと蓋材との接着界面で剥離させることで、内容物を取り出すことができる。 (Cover material)
The lid member includes, for example, a thermoplastic resin layer and a metal layer. As the resin layer, a thermoplastic resin that can be used for the first absorption layer can be used. As the metal layer, an aluminum foil such as a pure aluminum foil or an aluminum alloy foil can be used. Preferably, the lid is in a form in which a thermoplastic resin layer is coated on an aluminum foil, and the thermoplastic resin layer of the lid and the layer (first absorption layer) to which the blister pack laminate is bonded are: From the viewpoint of improving adhesiveness, the same resin can be included. Alternatively, an aluminum foil may be coated with an easy peel resin such as polyolefin polymer alloy, or an easy peel film may be laminated. In this case, the contents can be taken out by peeling at the bonding interface between the blister pack and the lid.
　図１は、ブリスターパック１の概略図である。ここでは、順に基材フィルム３、及び吸収フィルム４が積層してなるブリスターパック用積層体２に、蓋材５が接着されており、積層体２に形成されたドーム状のポケット部に、内容物１００が内包されている。図示していないが、ドライラミネート又は押出ラミネートによって積層させた場合、基材フィルムと吸収フィルムとの間には、接着剤層又は押出樹脂層が存在する。 FIG. 1 is a schematic view of a blister pack 1. Here, the cover material 5 is bonded to the laminate 2 for blister pack formed by laminating the base film 3 and the absorbent film 4 in order, and the content is stored in the dome-shaped pocket portion formed in the laminate 2. An object 100 is included. Although not shown, when laminated by dry lamination or extrusion lamination, an adhesive layer or an extrusion resin layer exists between the base film and the absorption film.
　図２は、本発明のブリスターパック１の層構造の概略図である。この図においては、ブリスターパック１のポケット部が形成されていない端部を示しており、順に、基材フィルム３の基材層３１、バリア層３２及び補強層３３、並びに吸収フィルム４が積層されてなるブリスターパック用積層体２に、蓋材５が接着されている。吸収フィルム４は、スキン層４１、第２の吸収層４２、及び第１の吸収層４３から構成され、また蓋材は熱可塑性樹脂層５１及び金属層５２から構成される。 FIG. 2 is a schematic view of the layer structure of the blister pack 1 of the present invention. In this figure, the edge part in which the pocket part of the blister pack 1 is not formed is shown, and the base material layer 31, the barrier layer 32, the reinforcing layer 33, and the absorption film 4 of the base material film 3 are laminated in order. A lid 5 is bonded to the blister pack laminate 2 formed as described above. The absorbent film 4 is composed of a skin layer 41, a second absorbent layer 42, and a first absorbent layer 43, and the lid member is composed of a thermoplastic resin layer 51 and a metal layer 52.
≪ブリスターパックの作製≫
〈比較例１～６及び実施例７～１０の積層体の作製〉
表１に記載の比較例１～６及び実施例７～１０の積層体を次のとおり作製した。 ≪Preparation of blister pack≫
<Preparation of laminates of Comparative Examples 1 to 6 and Examples 7 to 10>
The laminates of Comparative Examples 1 to 6 and Examples 7 to 10 shown in Table 1 were produced as follows.
　まず、無機吸収剤のゼオライト（ユニオン昭和株式会社、ゼオライト３Ａ）と、熱可塑性樹脂のＥＭＡＡ（三井・デュポンポリケミカル株式会社、ニュクレルＡＮ４２１１５Ｃ）のペレットとを、二軸押出機（株式会社池貝製、ＰＣＭ７０）を使用して、混練・ペレット化することで、第２の吸収層用のゼオライト含有率５３重量％（４５．６体積％）のペレットを得た。 First, an inorganic absorbent zeolite (Union Showa Co., Ltd., zeolite 3A) and a thermoplastic resin EMAA (Mitsui-DuPont Polychemical Co., Ltd., Nukurell AN42115C) pellets are mixed into a twin-screw extruder (Ikegai Corporation, Using PCM70), pellets having a zeolite content of 53 wt% (45.6 vol%) for the second absorbent layer were obtained by kneading and pelletizing.
　上記のペレットに、熱可塑性樹脂であるＬＬＤＰＥ（株式会社プライムポリマー製、エボリューＳＰ２５２０）のペレットを添加し、ドライブレンドによって混合することで、ゼオライト含有率を低くした、比較例１～６及び実施例７～８の第１の吸収層用の各種のペレットを得た。なお、実施例９及び１０においては、第１の吸収層を作製するのに、第２の吸収層用のペレットと同じペレットを用いた。 Comparative Examples 1 to 6 and Examples in which the pellet content of thermoplastic resin LLDPE (manufactured by Prime Polymer Co., Ltd., Evolue SP2520) was added to the above pellets and mixed by dry blending to lower the zeolite content. Various pellets for the first absorbent layer of 7 to 8 were obtained. In Examples 9 and 10, the same pellet as the pellet for the second absorption layer was used to produce the first absorption layer.
　スキン層用の樹脂として、ＬＬＤＰＥ（株式会社プライムポリマー製、エボリューＳＰ２５２０）のペレットを用意し、上記の第１の吸収層用ペレット及び第２の吸収層用ペレットを用いて、１７０℃での多層インフレーション法によって、インフレーション成形機を用いて（株式会社プラコー製、ＴＵＬ－６００Ｒ）、比較例１～６及び実施例７～１０で用いる吸収フィルムを得た。ここでは、全ての例で、スキン層の厚さを１０μｍとした。 As a resin for the skin layer, pellets of LLDPE (manufactured by Prime Polymer Co., Ltd., Evolution SP2520) are prepared, and the first absorbent layer pellet and the second absorbent layer pellet are used to form a multilayer at 170 ° C. By the inflation method, an absorption film used in Comparative Examples 1 to 6 and Examples 7 to 10 was obtained using an inflation molding machine (Puraco Co., Ltd., TUL-600R). Here, in all examples, the thickness of the skin layer was 10 μm.
　これらの吸収フィルムに、２５μｍのナイロン（Ｎｙ）フィルム、４０μｍのアルミニウム（Ａｌ）箔、及び６０μｍのポリ塩化ビニル（ＰＶＣ）フィルムを接着剤で貼り合わせた基材層、バリア層及び補強層を含む基材フィルム（株式会社ＵＡＣＪ製箔製、製品名：ＡＬ／ＡＬヨウキ）を、ドライラミネーター（株式会社テクノスマート製、ＩＮＶＥＸパイロットコーター）を用いて積層した。ここで、接着剤として、主剤（三井化学株式会社、タケラック（商標）Ａ１１４３）、硬化剤（三井化学株式会社、タケネート（商標）Ａ３）、及び酢酸エチルを、それぞれ９：１：１４．７の重量比で含むウレタン系接着剤を用いた。なお、接着剤の塗工量は５ｇ／ｍ２で行った。積層後、接着剤を硬化させるため、４０℃の環境下で３日間保存してエージングを行った。 These absorbent films include a base material layer, a barrier layer, and a reinforcing layer obtained by bonding a 25 μm nylon (Ny) film, a 40 μm aluminum (Al) foil, and a 60 μm polyvinyl chloride (PVC) film with an adhesive. A base film (manufactured by UACJ Co., Ltd., product name: AL / AL Yoki) was laminated using a dry laminator (manufactured by Techno Smart Co., Ltd., INVEX pilot coater). Here, as the adhesive, the main agent (Mitsui Chemicals, Takelac (trademark) A1143), the curing agent (Mitsui Chemicals, Takenate (trademark) A3), and ethyl acetate were respectively 9: 1: 14.7. A urethane-based adhesive contained in a weight ratio was used. The amount of adhesive applied was 5 g / m 2 . After the lamination, in order to cure the adhesive, it was aged by storing for 3 days in an environment of 40 ° C.
　このようにして、Ｎｙフィルム／／Ａｌ箔／／ＰＶＣフィルム／／スキン層／第２の吸収層／第１の吸収層という層構成の積層体を得た（なお、「／／」は接着剤を用いてのドライラミネートを意味している）。 Thus, a laminate having a layer structure of Ny film // Al foil // PVC film // skin layer / second absorption layer / first absorption layer was obtained (where “//” is an adhesive) Means dry laminate using).
〈比較例１１の積層体の作製〉
　吸収フィルムの代わりに５０μｍのＬＬＤＰＥ（株式会社プライムポリマー製、エボリューＳＰ２５２０）のフィルムを用いたことを除いて、比較例１と同様にして、比較例１１の積層体を得た。 <Preparation of the laminate of Comparative Example 11>
A laminated body of Comparative Example 11 was obtained in the same manner as Comparative Example 1 except that a film of 50 μm LLDPE (manufactured by Prime Polymer Co., Ltd., Evolution SP2520) was used instead of the absorbent film.
〈比較例１２の積層体の作製〉
　比較例１２の積層体として、比較例１で用いた基材フィルムを単独で用いた。 <Preparation of the laminate of Comparative Example 12>
As the laminate of Comparative Example 12, the base film used in Comparative Example 1 was used alone.
≪評価方法≫
〈ポケット部分の成形性〉
　このようにして得た積層体に、室温で深さ５．００～５．５０ｍｍの内容物のポケット部を成形した。成形機は、日本オートマチックマシン株式会社のハイスピード油圧プレス（ＨＹＰ５０５Ｈ）を用いた。プラグ材質は、粘度平均分子量５５０万の超高分子量ポリエチレン樹脂（製品名：ニューライト（商標）ＮＬ－Ｗ、作新工業株式会社）であり、プラグ径は１３ｍｍ、成形速度は２００ｍｍ／ｓとした。 ≪Evaluation method≫
<Moldability of pocket part>
A pocket portion of the contents having a depth of 5.00 to 5.50 mm at room temperature was formed on the laminate thus obtained. A high-speed hydraulic press (HYP505H) manufactured by Nippon Automatic Machine Co., Ltd. was used as the molding machine. The plug material is ultra high molecular weight polyethylene resin (product name: Newlite (trademark) NL-W, Sakushin Kogyo Co., Ltd.) having a viscosity average molecular weight of 5.5 million, the plug diameter is 13 mm, and the molding speed is 200 mm / s. .
　ここで試験は、各例の各深さについて１０回ずつ行い、成形したポケット部に割れやキズ、凹み等の成形不良が何回発生するかを目視で判断した。１０回全てで成形不良が発生せず成形可能であった場合を◎とし、８～９回で成形可能であった場合を○とし、５～７回で成形可能であった場合を△とし、４回以下でのみ成形可能であった場合を×とした。試験結果を表１に示す。 Here, the test was performed 10 times for each depth in each example, and it was visually determined how many molding defects such as cracks, scratches, and dents occurred in the molded pocket. The case where molding was possible without forming defects in all 10 times was marked as ◎, the case where molding was possible in 8-9 times was marked as ◯, and the case where molding was possible in 5-7 times was marked as △, The case where molding was possible only 4 times or less was marked as x. The test results are shown in Table 1.
〈表面粗さ〉
　比較例１～６及び実施例７～１０の積層体の第１の吸収層、比較例１１の積層体のＬＬＤＰＥフィルム、及び比較例１２の積層体のＰＶＣフィルムの表面粗さ（算術平均粗さＲａ）を、ＩＳＯ４２８７に準拠して、表面粗さ測定機（株式会社小坂研究所製、ＥＴ４０００ＡＫ）を用いて、フィルムのＭＤ方向及びＴＤ方向の両方向で測定した。ここでは、Ｒ２μｍの針先端、頂角６０°、ダイヤモンドの触針を用いた。試験結果を表１に示す。 <Surface roughness>
Surface roughness (arithmetic mean roughness) of the first absorbent layer of the laminates of Comparative Examples 1 to 6 and Examples 7 to 10, the LLDPE film of the laminate of Comparative Example 11, and the PVC film of the laminate of Comparative Example 12 Ra) was measured in both the MD direction and the TD direction of the film using a surface roughness measuring instrument (manufactured by Kosaka Laboratory Ltd., ET4000AK) in accordance with ISO4287. Here, an R2 μm needle tip, an apex angle of 60 °, and a diamond stylus were used. The test results are shown in Table 1.
〈すべり性〉
　比較例１～６及び実施例７～１０の積層体の第１の吸収層、比較例１１の積層体のＬＬＤＰＥフィルム、及び比較例１２の積層体のＰＶＣフィルムのすべり性を評価するために、それらの動摩擦係数μＤを、ＩＳＯ８２９５に準拠して、摩擦測定機（株式会社東洋精機製作所、ＴＲ－２）を用いて測定した。測定速度は、１００ｍｍ／ｍｉｎ、滑り片は、２００ｇ（４０ｃｍ２）、対サンプルは成形プラグと同じ材質の超高分子量ＰＥフィルム（粘度平均分子量５５０万、製品名：ニューライトフィルム＃５０Ｗ、使用樹脂：ニューライト（商標）ＮＬ－Ｗ　作新工業株式会社、算術平均粗さＲａ：ＭＤ方向０．０６７μｍ、ＴＤ方向０．０７３μｍ）を用いた。同様にして測定した静摩擦係数μＳの値と共に、試験結果を表１に示す。 <Slip property>
In order to evaluate the slip properties of the first absorbent layer of the laminates of Comparative Examples 1 to 6 and Examples 7 to 10, the LLDPE film of the laminate of Comparative Example 11, and the PVC film of the laminate of Comparative Example 12, Their dynamic friction coefficients μD were measured using a friction measuring machine (Toyo Seiki Seisakusho, TR-2) in accordance with ISO8295. The measurement speed is 100 mm / min, the sliding piece is 200 g (40 cm 2 ), the sample is an ultra-high molecular weight PE film (viscosity average molecular weight 5.5 million, product name: Newlite film # 50W, resin used) : Newlite (trademark) NL-W Sakushin Kogyo Co., Ltd., arithmetic average roughness Ra: MD direction 0.067 μm, TD direction 0.073 μm). The test results are shown in Table 1 together with the value of the static friction coefficient μS measured in the same manner.
〈吸収性〉
　比較例１～６及び実施例７～１０の積層体による吸収能力の確認のために、次のように吸収速度及び飽和吸収量を評価した。まず、１０ｃｍ角サンプルを準備し、重量を測定する。そして温度２３℃、相対湿度５０％の環境下に、それらのサンプルを静置し、静置して１、３、５、７時間後の重量を測定した。さらに数日間静置することで、重量変化がなくなった時点の重量から飽和吸収量を決定した。表１に各例の飽和吸収量、及び静置して１、３、５、７時間後の吸収量の飽和吸収量に対する割合（吸収率）を示す。また、第１の吸収層の厚みに応じた吸収率の時間経過を、図３（第１の吸収層：１０μｍ）及び図４（第１の吸収層：２０μｍ）に示す。 <Absorptivity>
In order to confirm the absorption capacity of the laminates of Comparative Examples 1 to 6 and Examples 7 to 10, the absorption rate and the saturated absorption amount were evaluated as follows. First, a 10 cm square sample is prepared and the weight is measured. Then, these samples were allowed to stand in an environment of a temperature of 23 ° C. and a relative humidity of 50%, and the weights were measured after 1, 3, 5, and 7 hours. Further, by allowing to stand for several days, the saturated absorption amount was determined from the weight when the weight change disappeared. Table 1 shows the saturated absorption amount of each example and the ratio (absorption rate) of the absorption amount after 1, 3, 5, and 7 hours after standing to the saturated absorption amount. Moreover, the time course of the absorption rate according to the thickness of the first absorption layer is shown in FIG. 3 (first absorption layer: 10 μm) and FIG. 4 (first absorption layer: 20 μm).
≪結果≫
　結果を以下の表１に示す。
Figure JPOXMLDOC01-appb-T000001
 ≪Result≫
The results are shown in Table 1 below.
Figure JPOXMLDOC01-appb-T000001
　比較例１～６の積層体を参照すると、５．５０ｍｍの深いポケット部を形成する場合に成形不良が多く発生することが分かる。また、これは第１の吸収層に吸収剤が入っていない比較例１及び比較例２よりも、吸収剤が入っている比較例３～６の方が、成形不良が発生しやすい傾向となっている。 Referring to the laminates of Comparative Examples 1 to 6, it can be seen that many molding defects occur when a deep pocket portion of 5.50 mm is formed. Further, compared to Comparative Examples 1 and 2 in which the absorbent is not contained in the first absorbent layer, Comparative Examples 3 to 6 containing the absorbent tend to cause molding defects more easily. ing.
　しかし、驚くべき事に、第１の吸収層に吸収剤をさらに多く含む、本発明に関する実施例７～１０の積層体では、成形不良が発生しにくいことが分かった。これは、これらの積層体の第１の吸収層が、高い表面粗さを有していること、及びすべり性が比較的良好であること（摩擦係数が低いこと）に起因しているものと考えられる。 However, surprisingly, it has been found that molding defects are less likely to occur in the laminates of Examples 7 to 10 relating to the present invention in which the first absorbent layer further contains an absorbent. This is due to the fact that the first absorbent layer of these laminates has a high surface roughness and that the slipperiness is relatively good (the coefficient of friction is low). Conceivable.
　比較例３～６で深いポケット部を形成する場合に成形不良が多く発生する原因としては、これらが比較例１及び比較例２に比較して高い表面粗さと良好なすべり性を有していたとしてもそれらは十分ではなく、逆に比較例３～６の積層体では第１の吸収層に無機吸収剤を含むことで樹脂の柔軟性が低下し、樹脂によるクッション効果が低下したものと考えられる。したがって、本発明に関する実施例７～１０の積層体でも、樹脂によるクッション効果は低下しているものと考えられるが、これらの積層体の第１の吸収層では高い表面粗さと良好なすべり性を有していることで、樹脂によるクッション効果の低下が顕在化しなくなったものと考えられる。さらに、本発明に関する実施例７～１０の積層体では、第１の吸収層に無機吸収剤を適切な量で含有していることで、プラグ材から力を受けた場合に、無機吸収剤粒子と樹脂が協働して応力を吸収・分散する、無機吸収剤と樹脂のクッション効果が、樹脂によるクッション効果の低下を上回るほど顕著に現れるようになったと考えられる。 When forming deep pocket portions in Comparative Examples 3 to 6, the reason why many molding defects occurred was that these had higher surface roughness and better slipperiness than Comparative Examples 1 and 2. However, they are not sufficient, and conversely, in the laminates of Comparative Examples 3 to 6, it was considered that the flexibility of the resin was reduced by including an inorganic absorbent in the first absorbent layer, and the cushioning effect by the resin was reduced. It is done. Therefore, it is considered that the cushioning effect by the resin is also lowered in the laminates of Examples 7 to 10 relating to the present invention, but the first absorbent layer of these laminates has high surface roughness and good slip properties. It is considered that the lowering of the cushioning effect due to the resin is no longer manifested by having it. Furthermore, in the laminates of Examples 7 to 10 relating to the present invention, when the first absorbent layer contains the inorganic absorbent in an appropriate amount, the inorganic absorbent particles when receiving force from the plug material. It is considered that the cushioning effect of the inorganic absorbent and the resin, which absorbs and disperses the stress in cooperation with the resin, appears more prominently than the decrease in the cushioning effect by the resin.
　実施例７～１０の積層体は、吸収速度についても、比較例１～６の積層体に比べて顕著に向上しており、深いポケット部分を作成する必要があり、かつ雰囲気中に強く影響を受ける内容物を収納するためのブリスターパックを成形する際には極めて有効であることが分かる。 In the laminates of Examples 7 to 10, the absorption rate is remarkably improved as compared with the laminates of Comparative Examples 1 to 6, and it is necessary to create a deep pocket portion, and strongly influence the atmosphere. It can be seen that it is extremely effective when forming a blister pack for storing the contents to be received.
　図３及び図４は、それぞれ厚さが１０μｍ及び２０μｍの第１の吸収層を有する積層体の吸収速度の比較を示している。この図からも分かるように、本発明の積層体では、比較例の積層体と比較して、吸収速度及び吸収量が向上している。 3 and 4 show a comparison of the absorption rates of the laminates having the first absorption layer having a thickness of 10 μm and 20 μm, respectively. As can be seen from this figure, in the laminate of the present invention, the absorption rate and the absorption amount are improved as compared with the laminate of the comparative example.
　１　　ブリスターパック包装体
　２　　ブリスターパック用積層体
　３　　基材フィルム
　３１　　基材層
　３２　　バリア層
　３３　　補強層
　４　　吸収フィルム
　４１　　スキン層
　４２　　第２の吸収層
　４３　　第１の吸収層
　５　　蓋材
　５１　　熱可塑性樹脂層
　５２　　金属層
　１００　　内容物 DESCRIPTION OF SYMBOLS 1 Blister pack package 2 Blister pack laminated body 3 Base film 31 Base layer 32 Barrier layer 33 Reinforcement layer 4 Absorption film 41 Skin layer 42 2nd absorption layer 43 1st absorption layer 5 Cover material 51 Thermoplastic resin Layer 52 Metal layer 100 Contents

Claims (10)

  1. 　基材フィルム及び吸収フィルムを有するブリスターパック用の積層体であって、前記吸収フィルムが以下の層を有する、積層体：
    　　熱可塑性樹脂を含み、かつ無機吸収剤の含有量が１０体積％未満である、前記基材フィルム側にあるスキン層；並びに
    　　熱可塑性樹脂及び無機吸収剤を含み、かつＩＳＯ４２８７に準拠して測定した場合の前記スキン層と反対側の面の算術平均粗さＲａが、０．７００μｍ以上である、ヒートシール性の第１の吸収層。     A laminate for a blister pack having a base film and an absorbent film, wherein the absorbent film has the following layers:
    A skin layer on the base film side containing a thermoplastic resin and containing an inorganic absorbent of less than 10% by volume; and containing a thermoplastic resin and an inorganic absorbent and measured in accordance with ISO 4287 The heat-absorbing first absorption layer, wherein the arithmetic mean roughness Ra of the surface opposite to the skin layer is 0.700 μm or more.
  2. 　前記第１の吸収層の前記スキン層と反対側の面の算術平均粗さＲａが、１．３００μｍ以下である、請求項１に記載の積層体。 The laminate according to claim 1, wherein the arithmetic average roughness Ra of the surface of the first absorbent layer opposite to the skin layer is 1.300 µm or less.
  3. 　ＩＳＯ８２９５に準拠して測定した場合の超高分子量ポリエチレンとの前記第１の吸収層の前記スキン層と反対側の面の動摩擦係数μＤが、０．４２以下である、請求項１又は２に記載の積層体。 The dynamic friction coefficient μD of the surface of the first absorbent layer opposite to the skin layer when measured according to ISO 8295 is 0.42 or less. Laminated body.
  4. 　前記ヒートシール性の第１の吸収層が、２８．８体積％超の無機吸収剤を含む、請求項１～３のいずれか一項に記載の積層体。 The laminate according to any one of claims 1 to 3, wherein the first heat-sealable absorbent layer contains an inorganic absorbent in an amount of more than 28.8% by volume.
  5. 　７０体積％以下である無機吸収剤及び熱可塑性樹脂を含む第２の吸収層を、前記第１の吸収層と前記スキン層との間に含む、請求項１～４のいずれか一項に記載の積層体。 The second absorption layer containing an inorganic absorbent and a thermoplastic resin that is 70% by volume or less is included between the first absorption layer and the skin layer, according to any one of claims 1 to 4. Laminated body.
  6. 　前記第１の吸収層及び第２の吸収層の無機吸収剤、並びに存在する場合には前記スキン層の無機吸収剤が、ゼオライト、アルミナ、酸化アルミニウム、ケイ酸マグネシウム、シリカゲル、酸化カルシウム、塩化カルシウム、硫酸カルシウム、硫酸マグネシウム、硫酸ナトリウム、炭酸カルシウム、酸化マグネシウム、酸化バリウム、五酸化二リン、過塩素酸マグネシウム、過マンガン酸カリウム、過マンガン酸ナトリウム、チオ硫酸ナトリウム、鉄粉、酸化第一鉄、第一鉄塩、塩化ナトリウム、臭化ナトリウム、ヨウ化ナトリウム、塩化カリウム、臭化カリウム、ヨウ化カリウム、塩化カルシウム、塩化マグネシウム、塩化バリウム、酸素欠乏酸化セリウム、亜硫酸塩、亜硫酸水素塩、亜ニチオン酸塩及びこれらの混合物からなる群よりそれぞれ独立して選択される、請求項４又は５に記載の積層体。 The inorganic absorbent of the first absorbent layer and the second absorbent layer, and if present, the inorganic absorbent of the skin layer is zeolite, alumina, aluminum oxide, magnesium silicate, silica gel, calcium oxide, calcium chloride , Calcium sulfate, magnesium sulfate, sodium sulfate, calcium carbonate, magnesium oxide, barium oxide, diphosphorus pentoxide, magnesium perchlorate, potassium permanganate, sodium permanganate, sodium thiosulfate, iron powder, ferrous oxide , Ferrous salt, sodium chloride, sodium bromide, sodium iodide, potassium chloride, potassium bromide, potassium iodide, calcium chloride, magnesium chloride, barium chloride, oxygen-deficient cerium oxide, sulfite, bisulfite, sub From the group consisting of nithionate and mixtures thereof. Selected respectively independently laminate according to claim 4 or 5.
  7. 　前記スキン層、第１の吸収層及び第２の吸収層の熱可塑性樹脂が、ポリオレフィン系樹脂、ポリ塩化ビニル、ポリスチレン、ポリカーボネート、ポリアミド、及びこれらの混合物からなる群よりそれぞれ独立して選択される、請求項４～６のいずれか一項に記載の積層体。 The thermoplastic resin of the skin layer, the first absorbent layer, and the second absorbent layer is independently selected from the group consisting of polyolefin resin, polyvinyl chloride, polystyrene, polycarbonate, polyamide, and mixtures thereof. The laminate according to any one of claims 4 to 6.
  8. 　前記基材フィルムが、以下を含む、請求項１～７のいずれか一項に記載の積層体：
    　　熱可塑性樹脂を含む基材層、及び
    　　前記スキン層側に位置し、かつ金属層を有するバリア層。     The laminate according to any one of claims 1 to 7, wherein the base film comprises:
    A base material layer containing a thermoplastic resin, and a barrier layer located on the skin layer side and having a metal layer.
  9. 　請求項１～８のいずれか一項に記載の積層体、並びに熱可塑性樹脂層及び金属層を有する蓋材を含み、前記積層体と前記蓋材とが少なくとも部分的に接着しており、かつ前記積層体にポケット部が形成されて前記積層体と前記蓋材との間に内容物が収納可能になっている、ブリスターパック。 The laminate according to any one of claims 1 to 8, and a lid having a thermoplastic resin layer and a metal layer, wherein the laminate and the lid are at least partially bonded, and A blister pack in which pockets are formed in the laminate and contents can be stored between the laminate and the lid.
  10. 　請求項９に記載のブリスターパックと、前記ポケット部に収納された内容物とを有するブリスターパック包装体。 A blister pack package having the blister pack according to claim 9 and the contents stored in the pocket portion.
PCT/JP2015/065654 2014-06-05 2015-05-29 Laminate for use in blister pack, blister pack using same, and blister pack packaging WO2015186640A1 (en)

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JP2019010775A (en) * 2017-06-29 2019-01-24 共同印刷株式会社 Film for moisture absorption and gas adsorption, and laminate for packaging
JP2020163745A (en) * 2019-03-29 2020-10-08 大日本印刷株式会社 Carbonic acid gas absorption laminate and valve-less package
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JP7380215B2 (en) 2019-12-27 2023-11-15 大日本印刷株式会社 Container packaging and its manufacturing method

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