WO2015194645A1

WO2015194645A1 - Absorbent layer for blister packs, laminate comprising same, and blister pack using said laminate

Info

Publication number: WO2015194645A1
Application number: PCT/JP2015/067659
Authority: WO
Inventors: 晋久岩崎; 彰宏木下; みどり加藤; 直希小川
Original assignee: 共同印刷株式会社
Priority date: 2014-06-18
Filing date: 2015-06-18
Publication date: 2015-12-23
Also published as: JPWO2015194645A1; TW201615517A

Abstract

The purpose of the present invention is to provide an absorbent layer for blister packs, which imparts sufficient formability and is free from forming failure even if a pocket is formed to a certain depth. An absorbent layer for blister packs according to the present invention sequentially comprises an outer skin layer, an intermediate layer containing an inorganic absorbent and a binder resin, and an inner skin layer containing a high-density polyethylene and a polypropylene resin in this order, and satisfies at least one of the following conditions (a)-(c). (a) The inner skin layer contains 3-70% by weight of a high-density polyethylene and 97-30% by weight of a polypropylene resin. (b) The arithmetic mean roughness (Ra) of a surface of the inner skin layer as determined in accordance with ISO 4287, said surface being on the reverse side of the intermediate layer-side surface, is 0.40 μm or more. (c) The coefficient of kinetic friction between the inner skin layer and an ultra high molecular weight polyethylene as determined in accordance with ISO 8295 is 0.200 or less.

Description

Absorbent layer for blister pack, laminate including the same, and blister pack using the same

The present invention relates to an absorbent layer for a blister pack, a laminate including the same, and a blister pack using the laminate. In particular, the present invention uses an absorbent layer for a blister pack that does not cause molding defects even when a pocket portion having a depth is formed for packaging a large drug, a laminate including the same, and the laminate. Regarding blister packs.

Powdered drugs are enclosed in thin paper bags or film bags, while drugs such as tablets or capsules are enclosed in blister packs called PTP (press-through packs). By pushing the medicine enclosed in the blister pack with a finger, the sheet-like lid can be broken and the medicine can be taken out.

● Drugs may alter the medicinal properties by absorbing moisture. Therefore, conventionally, a desiccant such as silica gel has been enclosed in an outer bag enclosing a blister pack. However, the operation of putting the desiccant into the outer bag takes time and there is a risk of accidental ingestion or accidental eating. In addition, after opening the exterior bag, the inside of the blister pack cannot be kept at a low humidity, and there is a problem in that the deterioration of the drug progresses. Furthermore, some chemicals are easily oxidatively decomposed, and others emit a specific odor. Therefore, there is a demand for absorbing gas such as oxygen and odor in the blister pack.

On the other hand, Patent Document 1 discloses a technique for improving the long-term stability of a drug by forming an absorbent layer having an absorbent inside a blister pack. Here, first, a dome-shaped pocket portion is formed in a laminate of a base material and an absorption layer which are barrier layers. And the chemical | medical agent which is a tablet is put into the pocket part, and this is sealed with the cover material. According to this technology, it is considered that it is possible to maintain a dry state, prevent oxidation, and efficiently remove odors without enclosing a desiccant or the like in the outer bag.

Also, some medicines are vulnerable to ultraviolet rays, and if the packaging container is transparent, the medicinal properties may deteriorate. On the other hand, Patent Document 1 further discloses a technique for forming an aluminum layer not only on the cover material on the back side of the blister pack but also on the front blister pack laminate, so-called aluminum blister packaging. According to this technique, since the aluminum layer is formed on the blister pack, the drug cannot be visually recognized, but the ultraviolet ray can be blocked and the barrier property can be further enhanced.

In a mode in which the above two technologies are simply combined, when forming a dome-shaped pocket in a blister pack laminate, the ceiling of the dome is torn or cracks are generated in the hem or shoulder. However, in order to cope with this, Patent Document 2 inserts a reinforcing layer using a specific polymer between the aluminum layer and the absorbing layer. In this embodiment, although there is a considerable improvement in formability, the shoulder portion of the pocket may tear or a pinhole may occur depending on the mold or molding depth of the molding machine.

International Publication No. 2006/115264 International Publication No. 2012/029323

Accordingly, the present invention relates to an absorbent layer for blister packs that does not cause molding defects even when pockets are formed to a certain depth and that provides sufficient formability, a laminate including the same, and a blister using the laminate. The purpose is to provide a pack.

The present inventors have found that the above problems can be solved by the following means.
[1] Outer skin layer;
For blister packs comprising an intermediate layer having an inorganic absorbent and a binder resin; and an inner skin layer having a high density polyethylene and a polypropylene resin in this order and satisfying at least one of the following conditions (a) to (c) Absorption layer:
(A) the inner skin layer contains 3 to 70% by weight of high density polyethylene and 97 to 30% by weight of a polypropylene resin;
(B) Arithmetic mean roughness Ra of the surface of the inner skin layer opposite to the intermediate layer when measured according to ISO 4287 is 0.40 μm or more; and (c) According to ISO 8295 The dynamic friction coefficient of the inner skin layer with the ultra high molecular weight polyethylene when measured is 0.200 or less.
[2] The absorbent layer according to [1], which satisfies the condition (a).
[3] The absorbent layer according to [2], wherein the inner skin layer contains 25 to 50% by weight of high-density polyethylene and 75 to 50% by weight of a polypropylene resin.
[4] The absorption layer according to [1], which satisfies the condition (b).
[5] The absorption layer according to [1], which satisfies the condition (c).
[6] A blister pack laminate comprising the absorbent layer according to any one of [1] to [5] and a base material layer on the outer skin layer side of the absorbent layer.
[7] The laminate for a blister pack according to [6], further including an aluminum layer between the base material layer and the absorption layer.
[8] The blister pack laminate according to [7], further including a reinforcing layer between the aluminum layer and the absorbing layer.
[9] The laminate according to any one of [6] to [8], and a lid member having an aluminum layer different from the resin layer and the aluminum layer, wherein the laminate and the lid member include A blister pack that is at least partially bonded and has a pocket portion formed in the laminate so that the contents can be stored between the laminate and the lid.
[10] A blister pack package comprising the blister pack according to [9] and the contents stored in the pocket portion.

According to the present invention, it is possible to produce a blister pack with an absorbent layer having a deep pocket while minimizing the occurrence of molding defects. By using such a blister pack, relatively large contents can be stored in a stable state for a long time.

It is the schematic of a blister pack with an absorption layer. It is the schematic of the layer structure of the blister pack of this invention. It is a figure which shows the surface roughness (arithmetic mean roughness Ra) of each example of an Example. It is a figure which shows the slipperiness (dynamic friction coefficient) of each example of an Example. It is a figure which shows the maximum indentation depth of each example of an Example.

<Absorbent layer for blister pack>
The absorbent layer for blister packs of the present invention includes an outer skin layer, an intermediate layer containing an inorganic absorbent and a binder resin, and an inner skin layer in this order. Since the inorganic absorbent contained in the intermediate layer is prevented from being detached during use and the absorbent layer can be easily produced, it is sandwiched between the upper and lower skin layers. Here, the outer skin layer is a layer used on the side (outside) opposite to the side into which the contents of the blister pack are put, and the inner skin layer is a layer used on the side into which the contents are put (inside).

As shown in FIG. 1, the blister pack absorbent layer 4 of the present invention can be used by being laminated with the base material layer 2 and the aluminum layer 3 in the blister pack 1 of the present invention. As shown in FIG. 2, the blister pack absorbent layer 4 of the present invention has an outer skin layer 41, an intermediate layer 42, and an inner skin layer 43.

An absorption layer including an outer skin layer, an intermediate layer, and an inner skin layer can be manufactured by an inflation method. This is a method for producing a multilayer film by extruding a plurality of resins into a tube shape at the same time by a plurality of extruders and sending the air into the tubes to inflate them. The intermediate layer of the absorbent layer is formed into a film or sheet by extrusion or injection molding such as inflation method, T-die method, coextrusion, etc., and the outer skin layer and inner skin layer are formed into a film by a known method. Then, the absorbent layer can be manufactured by laminating the intermediate layer.

Examples of the molding method for molding the pocket portion of the blister pack include a flat plate air forming method, a plug assist pressure forming method, a drum type vacuum forming method, and a plug forming method. Among these, a plug molding method using a cylindrical rod (plug material) having a round tip at a viscosity average molecular weight of 1 million or more is preferable for forming a pocket. However, if a deep pocket is formed by this method, a crack may occur in the shoulder portion or the skirt portion of the dome-shaped pocket portion.

When the friction between the plug material and the inner skin layer of the absorbent layer of the laminate in contact with the plug material is large, the blister pack laminate is cracked with high probability when the pocket portion is formed. Found that occurs. That is, when the friction between the plug material and the inner skin layer is large, only the contact portion between the plug material and the inner skin layer is greatly stretched, and it is considered that a large tensile stress is generated in the laminated body and a crack is generated. .

Therefore, the present inventors make the surface of the inner skin layer of the absorption layer easy to slide with the plug material, so that when the plug material is pushed into the inner skin layer, the entire pushing surface is strained as uniformly as possible, The present invention has been achieved.

(Inner skin layer)
The inner skin layer contains high-density polyethylene and polypropylene-based resin and satisfies at least one of the following conditions (a) to (c):
(A) containing 3 to 70% by weight of high density polyethylene and 97 to 30% by weight of polypropylene resin;
(B) Arithmetic mean roughness Ra of the surface opposite to the intermediate layer when measured according to ISO 4287 is 0.40 μm or more; and (c) Ultra high when measured according to ISO 8295 Coefficient of dynamic friction with molecular weight polyethylene is 0.200 or less.

When the inner skin layer satisfies one or more of the above conditions [1], a blister pack with an absorbent layer having a deep pocket can be produced while minimizing the occurrence of molding defects. it can.

In this specification, the high density polyethylene means a polyethylene having a density measured in accordance with JIS K6922-1 of 920 kg / m ³ or more, and this is generally a linear unit in which ethylene as a repeating unit has almost no branching. Bonded crystalline polyethylene. A preferred high density polyethylene has a density measured according to JIS K6922-1 of 942 kg / m ³ or more. The high density polyethylene used in the present invention may have a melt flow rate (MFR) measured in accordance with JIS K6922-1 in the range of 0.05 to 30 g / 10 min, preferably 0.10 to 10.0 g / The range is 10 min, more preferably 0.20 to 5.0 g / 5 min, and still more preferably 0.50 to 3.0 g / 10 min.

In this specification, a polypropylene resin is a resin containing a propylene group repeating unit in a polymer main chain of 30 mol% or more, 40 mol% or more, 50 mol% or more, 60 mol% or more, 70 mol% or more, or 80 mol% or more. Examples include polypropylene (PP) homopolymer, random polypropylene (random PP), block polypropylene (block PP), chlorinated polypropylene, carboxylic acid-modified polypropylene, and derivatives thereof, and mixtures thereof. The polypropylene resin used in the present invention may have a melt flow rate (MFR) measured in accordance with JIS K7210 in the range of 0.5 to 100 g / 10 min, preferably in the range of 1.5 to 50 g / 10 min. More preferably, it is in the range of 3.0 to 20 g / 10 min, and still more preferably in the range of 5.0 to 15 g / 10 min.

With respect to the condition (a), the inner skin layer is provided with appropriate elasticity in the inner skin layer by including 3 to 70% by weight of high density polyethylene and 97 to 30% by weight of polypropylene resin in the inner skin layer. And the friction between the plug member and the plug member can be reduced. Preferably, the inner skin layer comprises 5 to 65 wt% high density polyethylene and 95 to 35 wt% polypropylene-based resin, most preferably 25 to 50 wt% high density polyethylene and 75 to 50 wt%. Contains polypropylene resin.

Regarding the condition (b) above, the arithmetic average roughness Ra of the surface on the opposite side of the intermediate layer of the inner skin layer when measured according to ISO 4287 is 0.40 μm or more, preferably 0.45 μm or more, more preferably Is 0.50 μm or more, more preferably 0.55 μm or more. When the surface roughness is large, the contact area between the inner skin layer and the plug material is reduced, so that the friction with the plug material is reduced, and the local strain at the contact portion between the plug material and the inner skin layer is reduced. Less likely to occur. From the viewpoint of adhesion to other layers, the arithmetic surface roughness Ra is preferably 1.50 μm or less, more preferably 1.30 μm or less, and even more preferably 1.00 μm or less.

With respect to the condition (c), the dynamic friction coefficient (μD) between the ultrahigh molecular weight polyethylene and the inner skin layer when measured in accordance with ISO8295 is 0.200 or less, preferably 0.190 or less, more preferably 0. .185 or less, more preferably 0.180 or less, and most preferably 0.175 or less. Here, the ultra high molecular weight polyethylene is a polyethylene having a viscosity average molecular weight of 1 million or more measured based on JIS K7367-3: 1999, and particularly an ultra high molecular weight polyethylene resin having a molecular weight of 5.5 million (product name: Neulite ( Trademark) NL-W (manufactured by Sakushin Kogyo Co., Ltd.). This is because it is the same as the ultrahigh molecular weight polyethylene usually used for the plug material used when molding the pocket portion of the blister pack. When the coefficient of dynamic friction is small, the slip between the plug material and the inner skin layer is improved during the formation of the pocket portion, and local strain at the contact portion between the plug material and the inner skin layer is less likely to occur.

The inner skin layer contains high-density polyethylene and polypropylene-based resin, but may further contain other resins within the range satisfying the above conditions. Further, examples of the resin that can be used include other polyethylene resins, saturated or unsaturated polyester, polyvinyl chloride (PVC), polystyrene, and derivatives thereof, and mixtures thereof. Preferably, the inner skin layer includes the same resin as the intermediate layer with which the inner skin layer contacts and the resin layer on the surface of the lid on the inner skin layer side, thereby enhancing the adhesion between these layers.

In this specification, the polyethylene-based resin is a resin containing a repeating unit of an ethylene group in a polymer main chain of 30 mol% or more, 40 mol% or more, 50 mol% or more, 60 mol% or more, 70 mol% or more, or 80 mol% or more. For example, low density polyethylene (LDPE), linear low density polyethylene (LLDPE), medium density polyethylene (MDPE), high density polyethylene (HDPE), ethylene-acrylic acid copolymer (EAA), ethylene-methacrylic Acid copolymer (EMAA), ethylene-ethyl acrylate copolymer (EEA), ethylene-methyl acrylate copolymer (EMA), ethylene vinyl acetate copolymer (EVA), carboxylic acid modified polyethylene, carboxylic acid modified ethylene vinyl Acetate copolymer and Derivatives of al, as well as selected from the group consisting of mixtures.

The thickness of the inner skin layer is preferably 5 μm or more, 10 μm or more, or 20 μm or more, and preferably 100 μm or less, 70 μm or less, 50 μm or less, or 40 μm or less.

(Outer skin layer)
Examples of the resin constituting the outer skin layer include polyethylene resins, polypropylene resins, saturated or unsaturated polyesters, polyvinyl chloride (PVC), polystyrene, and derivatives thereof, and mixtures thereof. Among these, in particular, a resin in which LLDPE and random PP are combined is preferable in terms of imparting appropriate elasticity to the film. Preferably, the outer skin layer contains the same resin as the intermediate layer, thereby enhancing the adhesion with the intermediate layer.

The thickness of the outer skin layer is preferably 5 μm or more, 10 μm or more, or 20 μm or more from the viewpoint of obtaining appropriate moldability and elasticity, and is preferably 100 μm or less, 70 μm or less, 50 μm or less, or 40 μm or less. .

(Middle layer)
In the intermediate layer, an inorganic absorbent is dispersed in a binder resin. The intermediate layer functions as an absorption layer that absorbs moisture and organic components in the blister pack.

Examples of inorganic absorbents that can be used in the intermediate layer include chemical adsorbents such as calcium oxide, calcium chloride, calcium sulfate, magnesium sulfate, and sodium sulfate, and physical adsorbents such as aluminum oxide, quicklime, silica gel, and inorganic molecular sieves. Can be mentioned. Examples of inorganic molecular sieves include, but are not limited to, aluminosilicate minerals, clays, porous glass, microporous activated carbon, zeolite, activated carbon, or compounds having an open structure capable of diffusing small molecules such as water. Can be mentioned. Such an inorganic absorbent can obtain high hygroscopicity even in a low humidity region, and absorbs moisture slightly contained in the blister pack, even in such a low relative humidity environment. It is particularly preferable to use an absorbent that can exhibit high absorbability.

As the zeolite, natural zeolite, artificial zeolite, synthetic zeolite or the like can be used. Zeolite is a porous granular material used to separate substances according to the difference in molecular size, and has a structure with uniform pores. Therefore, water (steam, water vapor), organic gas, etc. can be absorbed. An example of a synthetic zeolite is a molecular sieve. Among these, a molecular sieve having a pore (absorption port) diameter of 0.3 nm to 1 nm can be used. In general, molecular sieves having pore sizes of 0.3 nm, 0.4 nm, 0.5 nm, and 1 nm are referred to as molecular sieve 3A, molecular sieve 4A, molecular sieve 5A, and molecular sieve 13X, respectively. The average particle size of the molecular sieve (particle size at an integrated value of 50% in the particle size distribution determined by the laser diffraction / scattering method) is, for example, about 10 μm. In the present invention, these zeolites can be properly used in accordance with the object to be absorbed and the properties of the contents.

In particular, when absorbing odor, it is preferable to use hydrophobic zeolite because organic gas is often the causative substance. Hydrophobic zeolite is a generic term for a so-called high silica zeolite in which aluminum atoms in the crystal skeleton of the zeolite are reduced by dealumination to increase the silica-alumina ratio. Hydrophobic zeolite is a zeolite that loses its affinity for polar substances such as water and absorbs nonpolar substances more strongly, and more easily absorbs organic gases and the like. As the hydrophobic molecular sieve which is an example of the hydrophobic zeolite, those having a pore diameter of 0.6 to 0.9 nm can be used, and examples thereof include Abscents 1000, Abscents 2000, Abscents 3000 (manufactured by Union Showa Co., Ltd.) and the like. . The pore diameter can be confirmed by structural analysis by X-ray diffraction. The average particle size of the hydrophobic zeolite (particle size at an integrated value of 50% in the particle size distribution determined by the laser diffraction / scattering method) is, for example, 3 to 5 μm.

From the viewpoint of absorption capacity, the inorganic absorbent is 5% by weight or more, 10% by weight or more, 20% by weight or more, 30% by weight or more, 40% by weight or more, or 50% by weight or more based on the weight of the intermediate layer. In the range of 90% by weight, 80% by weight, 70% by weight or less, or 60% by weight or less in the intermediate layer from the viewpoint of dispersibility in the binder resin and moldability. Can be included.

Further, the inorganic absorbent can be 5% by volume or more, 10% by volume or more, 20% by volume or more, or 30% by volume or more, 70.0% by volume or less, 65% by volume or less, 60% by volume or less, It can be 55 volume% or less, or 50 volume% or less.

In addition, when calculating the volume% of the inorganic absorbent contained in the layer, if the specific gravity of the inorganic absorbent is unclear, the specific gravity of the layer is obtained by measurement, the measured value, the inorganic absorbent and The volume% of the inorganic absorbent may be determined from the added weight of the thermoplastic resin and the specific gravity of the thermoplastic resin. For example, when the specific gravity of a layer formed using 50 g of an inorganic absorbent and 50 g of a thermoplastic resin having a specific gravity of 0.9 g / cm ³ is 1.1 g / cm ³ , it is included in the layer. The inorganic absorbent can be calculated to have a specific gravity of 1.41 g / cm ^3, and it can be said that 38.9% by volume is present in the layer.

The inorganic absorbent may be contained in the inner skin layer and / or the outer skin layer, but considering the moldability of these layers and the ease of bonding with other layers, etc., it is 40% by volume or less. 30 volume% or less, 28.8 volume% or less, 20 volume% or less, 10 volume% or less, or 5 volume% or less.

Examples of the binder resin that can be used for the intermediate layer include polyethylene resins, polypropylene resins, saturated or unsaturated polyesters, ionomers, polyvinyl chloride (PVC), polystyrene, and derivatives thereof, and mixtures thereof.

The thickness of the intermediate layer is preferably 20 μm or more, 30 μm or more, or 40 μm or more from the viewpoint of absorption capacity, moldability, and elasticity, and is 500 μm or less, 300 μm or less, 200 μm or less, 150 μm or less, or 100 μm or less. It is preferable.

<Laminated body for blister pack>
The laminated body for blister packs of this invention has said base material layer by the side of the outer skin layer of said absorption layer and said absorption layer. Preferably, the laminated body for blister packs of this invention has an aluminum layer between an absorption layer and a base material layer. Moreover, you may have a reinforcement layer between this aluminum layer and an absorption layer. Moreover, you may have an adhesive layer between any two layers of a base material layer, an aluminum layer, a reinforcement layer, and an absorption layer.

For example, as shown in FIG. 1, the laminate 10 for blister packs of the present invention has a base material layer 2, an aluminum layer 3, and an absorption layer 4.

As a method of bonding any two layers of the base material layer, the aluminum layer, the reinforcing layer, and the absorption layer, a known laminating method such as dry lamination or extrusion lamination can be used.

(Base material layer)
The resin used for the base material layer is not particularly limited as long as it provides a suitable moldability to the blister pack laminate. For example, polyethylene resins, polypropylene resins, polyvinyl chloride, polyvinylidene chloride, polychlorotrifluoroethylene, polytetrafluoroethylene, saturated or unsaturated polyesters (eg, polyethylene terephthalate, polybutylene terephthalate), and polyamides (eg, Nylon (R), nylon 6,

nylon

6,6, nylon MXD6), and mixtures thereof. Preferably, those that prevent entry of moisture, oxygen, and the like from the outside and are excellent in moisture resistance are preferable, and polypropylene resins, polyamides, and polyethylene terephthalate are particularly preferable.

The thickness of the base material layer is preferably 10 μm or more, 20 μm or more, or 30 μm or more, and preferably 300 μm or less, 200 μm or less, or 100 μm or less.

(Aluminum layer)
The aluminum layer is used for imparting barrier properties. This may be a pure aluminum-based aluminum foil or an aluminum alloy-based aluminum foil. The thickness of the aluminum layer is preferably 7 μm or more, 10 μm or more, or 20 μm or more, and 60 μm or less, 50 μm or less, or 40 μm or less in order to give appropriate moldability and elasticity to the blister pack laminate.

(Reinforcing layer)
A reinforcement layer is used in order to improve the moldability of the laminated body for blister packs. This may consist of polyvinyl chloride, saturated or unsaturated polyesters (eg polyethylene terephthalate, polybutylene terephthalate), polyamides and mixtures thereof. The thickness of the reinforcing layer is preferably 15 μm or more, or 25 μm or more, and is 60 μm or less, or 50 μm or less. In the present invention, the reinforcing layer described in Patent Document 3 can be used as the reinforcing layer.

The laminated body for blister packs of the present invention includes a printed layer, an anchor coat layer for enhancing adhesion between two layers, a primer layer, between any two layers of a base material layer, an aluminum layer, a reinforcing layer, and an absorbent layer. You may have.

<Blister pack and blister pack package>
The blister pack of this invention has said laminated body for blister packs, and a cover material. The laminate and the lid material are at least partially adhered, and in particular, when the two outermost layers of the above-described blister pack laminate are the inner skin layer of the base material layer and the absorbent layer, the lid material is the inner skin layer. Glue. Blister pack that contains the contents in the pocket part of the blister pack by forming the pocket part for storing the contents in the blister pack laminate and then storing the contents in the pocket part and bonding the lid material A package can be produced.

(Cover material)
The lid member includes a resin layer, and further includes an aluminum layer different from the aluminum layer that may be included in the above-described blister pack laminate. Here, “another aluminum layer” may be the same material and thickness, that is, the same aluminum layer may be present in each of the blister pack laminate and the lid. is doing. The resin of the resin layer is selected from the group consisting of polypropylene resin, polyvinyl chloride, ethylene vinyl acetate copolymer, and mixtures thereof. Preferably, the lid member has a form in which an aluminum layer is coated with a resin layer. Preferably, the resin layer of the lid member and the layer (inner skin layer) to which the laminated body for blister packs adheres contain the same resin from the viewpoint of enhancing the adhesiveness.

(Contents)
The contents of the blister pack of the present invention are not limited as long as they can be deteriorated by contact with the outside air, and examples thereof include drugs, foods, cosmetics, medical devices, electronic parts and the like. Moreover, as a chemical | medical agent, a cleaning agent, an agrochemical, etc. are included besides a pharmaceutical formulation.

FIG. 1 is a schematic view of a blister pack 1 with an absorbent layer. Here, a lid material 5 is bonded to a blister pack laminate 10 in which a base material layer 2, an aluminum layer 3, and an absorbent layer 4 are laminated in order, and a dome-shaped pocket formed in the laminate 10 The content 100 is included in the part. Although not shown, when the layers are laminated by a dry lamination method, there are adhesive layers between the base material layer and the aluminum layer and between the aluminum layer and the absorption layer.

FIG. 2 is a schematic diagram of the layer structure of the blister pack of the present invention. In this figure, the end portion of the blister pack where the pocket portion is not formed is shown. In the blister pack laminate 10 in which the base material layer 2, the aluminum layer 3, and the absorbent layer 4 are laminated in this order. The lid 5 is adhered. The absorbent layer 4 includes an outer skin layer 41, an intermediate layer 42, and an inner skin layer 43, and the lid member includes a resin layer 51 and an aluminum layer 52. The laminate 10 is formed with a pocket portion for accommodating the contents.

<Sample creation>
The laminated bodies for blister packs of Examples 1 to 4 and Comparative Examples 1 to 5 were changed to only the configuration of the inner skin layer, and were configured as shown in Table 1 and Table 2 below.

For the absorption layer, first, the material of each layer is put into a twin-screw kneading extruder (PCM-30 manufactured by Ikekai Co., Ltd.), kneaded while heating and melting the resin, and then extruded into a pellet to cool. The outer skin layer pellet, the intermediate layer pellet, and the inner skin layer pellet were obtained. Using each pellet, a film serving as an absorption layer was formed by coextrusion molding using an inflation molding method. Inflation molding was performed with a three-layer inflation molding machine (3SOIB, Placo Corporation) at a resin temperature of 180 ° C. and a take-up speed of 13 m / min.

The base layer, the aluminum layer, the reinforcing layer, and the outer skin layer of the absorption layer were all laminated by a dry lamination method. In that case, as an adhesive, a urethane-based adhesive (Takelac ™ and Takenate ™) containing the main agent (A1143), the curing agent (A3), and ethyl acetate in a weight ratio of 9: 1: 10, respectively. Mitsui Chemicals, Inc.). The coating amount of the adhesive between each layer was 5 g / m ² . After the lamination, in order to cure the adhesive, it was aged by storing for 3 days in an environment of 40 ° C.

<Evaluation 1: Surface roughness>
The surface roughness (arithmetic mean roughness Ra) of the surface on the side opposite to the intermediate layer of the inner skin layer of the laminate for blister packs of Examples 1 to 4 and Comparative Examples 1 to 5 was determined according to ISO 4287. Measurement was performed using a thickness measuring machine (ET4000AK, Kosaka Laboratory Ltd.). An R2 μm needle tip, apex angle of 60 °, and a diamond stylus were used. The results for the arithmetic average roughness Ra of the inner skin layer are shown in FIG.

<Evaluation 2: Sliding property>
Using a friction measuring machine (TR-2, Toyo Seiki Seisakusyo Co., Ltd.), the sliding properties (dynamic friction coefficient) of the laminates for blister packs of Examples 1 to 4 and Comparative Examples 1 to 5 were based on JIS-K7125. Measured. The measuring speed is 100 mm / min, the sliding piece is 200 g (40 cm ² ), the sample is an ultra-high molecular weight polyethylene film (viscosity average molecular weight 5.5 million, product name: Newlite film NL-W) Kogyo Co., Ltd.) was used. The result about the dynamic friction coefficient of the inner skin layer is shown in FIG.

When evaluating the surface roughness (arithmetic average roughness Ra) and the slip property (dynamic friction coefficient), the surface roughness is large and the slip property is high when HDPE is contained in less than 75 parts by weight. Further, in Comparative Examples 1 and 2 containing LLDPE instead of HDPE, the surface roughness is low and the slipperiness is also low. Although not limited to theory, this is considered to be because HDPE has a high density and therefore has low compatibility with PP, and when these are blended, a sea island structure is formed and the surface is roughened.

<Evaluation 3: Molding test>
On the blister pack laminates of Examples 1 to 4 and Comparative Examples 1 to 5, drug pockets having a depth of 4.75 to 5.75 mm were formed at room temperature. A high-speed hydraulic press (HYP505H) manufactured by Nippon Automatic Machine Co., Ltd. was used as the molding machine. The plug material is ultra high molecular weight polyethylene resin (product name: Newlite (trademark) NL-W, Sakushin Kogyo Co., Ltd.) having a viscosity average molecular weight of 5.5 million, the plug diameter is 13 mm, and the molding speed is 200 mm / s. .

For each example, the maximum indentation depth that can be formed was evaluated. Here, the test is performed 10 times for each depth of each example, and when the appearance is not visually observed such as cracks, scratches, dents, etc. in the pockets formed by all 10 times, the conditions under which molding is possible It was. The test results are shown in FIG.

The laminate (Comparative Example 1) including a conventional LLDPE 100% inner skin layer has a low maximum indentation depth of 4.75 mm. Moreover, also in the laminated body (comparative example 2) containing the inner skin layer which consists of LLDPE and PP, the crack generate | occur | produced in the shoulder part of the dome shape of a pocket, and the maximum indentation depth became 4.75 mm. Considering also that the thickness of the top surface portion is not thin, it is considered that the plug and the surface of the laminate are not slipped at the time of molding, and an excessive load is applied to the shoulder portion. On the other hand, in the laminate including the inner skin layers of Examples 1 to 4 having high slip properties, the maximum indentation depth was 5.50 mm or more. In addition, although the laminated body (comparative example 5) containing PP100% of inner skin layers was favorable in slip property, the moldability was as low as 5.00 mm. This is presumably because the elastic modulus of PP is lower than that of HDPE, and the force that stretches the inner skin layer during molding is transmitted non-uniformly to the aluminum layer, resulting in molding defects such as cracks.

In the laminated body for blister packs using the absorbent layer of the present invention, deep pockets can be formed, and the blister packs using the same are stable for a long period of time (inhibition of alteration). Can be stored at.

DESCRIPTION OF SYMBOLS 1 Blister pack package with absorption layer 10 Laminate for blister pack 2 Base material layer 3 Aluminum layer 4 Absorption layer 41 Outer skin layer 42 Intermediate layer 43 Skin layer 5 Lid material 51 Resin layer 52 Aluminum layer 100 Contents

Claims

Outer skin layer;
For blister packs comprising an intermediate layer having an inorganic absorbent and a binder resin; and an inner skin layer having a high density polyethylene and a polypropylene resin in this order and satisfying at least one of the following conditions (a) to (c) Absorption layer:
(A) the inner skin layer contains 3 to 70% by weight of high density polyethylene and 97 to 30% by weight of a polypropylene resin;
(B) Arithmetic mean roughness Ra of the surface of the inner skin layer opposite to the intermediate layer when measured according to ISO 4287 is 0.40 μm or more; and (c) According to ISO 8295 The dynamic friction coefficient of the inner skin layer with the ultra high molecular weight polyethylene when measured is 0.200 or less.
The absorption layer according to claim 1, wherein the condition (a) is satisfied.
The absorption layer according to claim 2, wherein the inner skin layer contains 25 to 50% by weight of high-density polyethylene and 75 to 50% by weight of a polypropylene resin.
The absorption layer according to claim 1, which satisfies the condition (b).
The absorption layer according to claim 1, which satisfies the condition (c).
A blister pack laminate comprising the absorbent layer according to any one of claims 1 to 5 and a base material layer on the outer skin layer side of the absorbent layer.
The laminated body for blister packs of Claim 6 which further has an aluminum layer between the said base material layer and the said absorption layer.
The laminated body for blister packs of Claim 7 which further has a reinforcement layer between the said aluminum layer and the said absorption layer.
9. The laminate according to any one of claims 6 to 8, and a lid member having an aluminum layer different from the resin layer and the aluminum layer, wherein the laminate and the lid member are at least partially bonded. A blister pack that has a pocket portion formed in the laminate and that can store contents between the laminate and the lid.
A blister pack package having the blister pack according to claim 9 and the contents stored in the pocket portion.