WO2015194645A1 - Couche absorbante pour emballages-coques, stratifié comprenant celle-ci et emballage-coque utilisant ledit stratifié - Google Patents

Couche absorbante pour emballages-coques, stratifié comprenant celle-ci et emballage-coque utilisant ledit stratifié Download PDF

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Publication number
WO2015194645A1
WO2015194645A1 PCT/JP2015/067659 JP2015067659W WO2015194645A1 WO 2015194645 A1 WO2015194645 A1 WO 2015194645A1 JP 2015067659 W JP2015067659 W JP 2015067659W WO 2015194645 A1 WO2015194645 A1 WO 2015194645A1
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Prior art keywords
layer
laminate
inner skin
skin layer
blister pack
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PCT/JP2015/067659
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English (en)
Japanese (ja)
Inventor
晋久 岩崎
彰宏 木下
みどり 加藤
直希 小川
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共同印刷株式会社
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Priority to JP2016529526A priority Critical patent/JPWO2015194645A1/ja
Publication of WO2015194645A1 publication Critical patent/WO2015194645A1/fr

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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B32—LAYERED PRODUCTS
    • B32B—LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00—Layered products comprising a layer of synthetic resin
    • B32B27/32—Layered products comprising a layer of synthetic resin comprising polyolefins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D65/00—Wrappers or flexible covers; Packaging materials of special type or form
    • B65D65/38—Packaging materials of special type or form
    • B65D65/40—Applications of laminates for particular packaging purposes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28—Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/34—Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents and having several recesses to accommodate a series of articles or quantities of material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26—Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators

Definitions

  • the present invention relates to an absorbent layer for a blister pack, a laminate including the same, and a blister pack using the laminate.
  • the present invention uses an absorbent layer for a blister pack that does not cause molding defects even when a pocket portion having a depth is formed for packaging a large drug, a laminate including the same, and the laminate.
  • blister packs Regarding blister packs.
  • Powdered drugs are enclosed in thin paper bags or film bags, while drugs such as tablets or capsules are enclosed in blister packs called PTP (press-through packs).
  • PTP press-through packs
  • ⁇ Drugs may alter the medicinal properties by absorbing moisture. Therefore, conventionally, a desiccant such as silica gel has been enclosed in an outer bag enclosing a blister pack.
  • a desiccant such as silica gel has been enclosed in an outer bag enclosing a blister pack.
  • the operation of putting the desiccant into the outer bag takes time and there is a risk of accidental ingestion or accidental eating.
  • the inside of the blister pack cannot be kept at a low humidity, and there is a problem in that the deterioration of the drug progresses.
  • some chemicals are easily oxidatively decomposed, and others emit a specific odor. Therefore, there is a demand for absorbing gas such as oxygen and odor in the blister pack.
  • Patent Document 1 discloses a technique for improving the long-term stability of a drug by forming an absorbent layer having an absorbent inside a blister pack.
  • a dome-shaped pocket portion is formed in a laminate of a base material and an absorption layer which are barrier layers.
  • medical agent which is a tablet is put into the pocket part, and this is sealed with the cover material. According to this technology, it is considered that it is possible to maintain a dry state, prevent oxidation, and efficiently remove odors without enclosing a desiccant or the like in the outer bag.
  • Patent Document 1 further discloses a technique for forming an aluminum layer not only on the cover material on the back side of the blister pack but also on the front blister pack laminate, so-called aluminum blister packaging. According to this technique, since the aluminum layer is formed on the blister pack, the drug cannot be visually recognized, but the ultraviolet ray can be blocked and the barrier property can be further enhanced.
  • Patent Document 2 inserts a reinforcing layer using a specific polymer between the aluminum layer and the absorbing layer.
  • the shoulder portion of the pocket may tear or a pinhole may occur depending on the mold or molding depth of the molding machine.
  • the present invention relates to an absorbent layer for blister packs that does not cause molding defects even when pockets are formed to a certain depth and that provides sufficient formability, a laminate including the same, and a blister using the laminate.
  • the purpose is to provide a pack.
  • Outer skin layer For blister packs comprising an intermediate layer having an inorganic absorbent and a binder resin; and an inner skin layer having a high density polyethylene and a polypropylene resin in this order and satisfying at least one of the following conditions (a) to (c) Absorption layer: (A) the inner skin layer contains 3 to 70% by weight of high density polyethylene and 97 to 30% by weight of a polypropylene resin; (B) Arithmetic mean roughness Ra of the surface of the inner skin layer opposite to the intermediate layer when measured according to ISO 4287 is 0.40 ⁇ m or more; and (c) According to ISO 8295 The dynamic friction coefficient of the inner skin layer with the ultra high molecular weight polyethylene when measured is 0.200 or less.
  • a blister pack package comprising the blister pack according to [9] and the contents stored in the pocket portion.
  • the absorbent layer for blister packs of the present invention includes an outer skin layer, an intermediate layer containing an inorganic absorbent and a binder resin, and an inner skin layer in this order. Since the inorganic absorbent contained in the intermediate layer is prevented from being detached during use and the absorbent layer can be easily produced, it is sandwiched between the upper and lower skin layers.
  • the outer skin layer is a layer used on the side (outside) opposite to the side into which the contents of the blister pack are put, and the inner skin layer is a layer used on the side into which the contents are put (inside).
  • the blister pack absorbent layer 4 of the present invention can be used by being laminated with the base material layer 2 and the aluminum layer 3 in the blister pack 1 of the present invention.
  • the blister pack absorbent layer 4 of the present invention has an outer skin layer 41, an intermediate layer 42, and an inner skin layer 43.
  • An absorption layer including an outer skin layer, an intermediate layer, and an inner skin layer can be manufactured by an inflation method.
  • This is a method for producing a multilayer film by extruding a plurality of resins into a tube shape at the same time by a plurality of extruders and sending the air into the tubes to inflate them.
  • the intermediate layer of the absorbent layer is formed into a film or sheet by extrusion or injection molding such as inflation method, T-die method, coextrusion, etc., and the outer skin layer and inner skin layer are formed into a film by a known method. Then, the absorbent layer can be manufactured by laminating the intermediate layer.
  • Examples of the molding method for molding the pocket portion of the blister pack include a flat plate air forming method, a plug assist pressure forming method, a drum type vacuum forming method, and a plug forming method.
  • a plug molding method using a cylindrical rod (plug material) having a round tip at a viscosity average molecular weight of 1 million or more is preferable for forming a pocket.
  • a crack may occur in the shoulder portion or the skirt portion of the dome-shaped pocket portion.
  • the blister pack laminate is cracked with high probability when the pocket portion is formed. Found that occurs. That is, when the friction between the plug material and the inner skin layer is large, only the contact portion between the plug material and the inner skin layer is greatly stretched, and it is considered that a large tensile stress is generated in the laminated body and a crack is generated. .
  • the present inventors make the surface of the inner skin layer of the absorption layer easy to slide with the plug material, so that when the plug material is pushed into the inner skin layer, the entire pushing surface is strained as uniformly as possible, The present invention has been achieved.
  • the inner skin layer contains high-density polyethylene and polypropylene-based resin and satisfies at least one of the following conditions (a) to (c): (A) containing 3 to 70% by weight of high density polyethylene and 97 to 30% by weight of polypropylene resin; (B) Arithmetic mean roughness Ra of the surface opposite to the intermediate layer when measured according to ISO 4287 is 0.40 ⁇ m or more; and (c) Ultra high when measured according to ISO 8295 Coefficient of dynamic friction with molecular weight polyethylene is 0.200 or less.
  • a blister pack with an absorbent layer having a deep pocket can be produced while minimizing the occurrence of molding defects. it can.
  • the high density polyethylene means a polyethylene having a density measured in accordance with JIS K6922-1 of 920 kg / m 3 or more, and this is generally a linear unit in which ethylene as a repeating unit has almost no branching. Bonded crystalline polyethylene.
  • a preferred high density polyethylene has a density measured according to JIS K6922-1 of 942 kg / m 3 or more.
  • the high density polyethylene used in the present invention may have a melt flow rate (MFR) measured in accordance with JIS K6922-1 in the range of 0.05 to 30 g / 10 min, preferably 0.10 to 10.0 g / The range is 10 min, more preferably 0.20 to 5.0 g / 5 min, and still more preferably 0.50 to 3.0 g / 10 min.
  • MFR melt flow rate
  • a polypropylene resin is a resin containing a propylene group repeating unit in a polymer main chain of 30 mol% or more, 40 mol% or more, 50 mol% or more, 60 mol% or more, 70 mol% or more, or 80 mol% or more.
  • examples include polypropylene (PP) homopolymer, random polypropylene (random PP), block polypropylene (block PP), chlorinated polypropylene, carboxylic acid-modified polypropylene, and derivatives thereof, and mixtures thereof.
  • the polypropylene resin used in the present invention may have a melt flow rate (MFR) measured in accordance with JIS K7210 in the range of 0.5 to 100 g / 10 min, preferably in the range of 1.5 to 50 g / 10 min. More preferably, it is in the range of 3.0 to 20 g / 10 min, and still more preferably in the range of 5.0 to 15 g / 10 min.
  • MFR melt flow rate
  • the inner skin layer is provided with appropriate elasticity in the inner skin layer by including 3 to 70% by weight of high density polyethylene and 97 to 30% by weight of polypropylene resin in the inner skin layer. And the friction between the plug member and the plug member can be reduced.
  • the inner skin layer comprises 5 to 65 wt% high density polyethylene and 95 to 35 wt% polypropylene-based resin, most preferably 25 to 50 wt% high density polyethylene and 75 to 50 wt%. Contains polypropylene resin.
  • the arithmetic average roughness Ra of the surface on the opposite side of the intermediate layer of the inner skin layer when measured according to ISO 4287 is 0.40 ⁇ m or more, preferably 0.45 ⁇ m or more, more preferably Is 0.50 ⁇ m or more, more preferably 0.55 ⁇ m or more.
  • the surface roughness is large, the contact area between the inner skin layer and the plug material is reduced, so that the friction with the plug material is reduced, and the local strain at the contact portion between the plug material and the inner skin layer is reduced. Less likely to occur.
  • the arithmetic surface roughness Ra is preferably 1.50 ⁇ m or less, more preferably 1.30 ⁇ m or less, and even more preferably 1.00 ⁇ m or less.
  • the dynamic friction coefficient ( ⁇ D) between the ultrahigh molecular weight polyethylene and the inner skin layer when measured in accordance with ISO8295 is 0.200 or less, preferably 0.190 or less, more preferably 0. .185 or less, more preferably 0.180 or less, and most preferably 0.175 or less.
  • the ultra high molecular weight polyethylene is a polyethylene having a viscosity average molecular weight of 1 million or more measured based on JIS K7367-3: 1999, and particularly an ultra high molecular weight polyethylene resin having a molecular weight of 5.5 million (product name: Neulite ( Trademark) NL-W (manufactured by Sakushin Kogyo Co., Ltd.).
  • the inner skin layer contains high-density polyethylene and polypropylene-based resin, but may further contain other resins within the range satisfying the above conditions.
  • the resin that can be used include other polyethylene resins, saturated or unsaturated polyester, polyvinyl chloride (PVC), polystyrene, and derivatives thereof, and mixtures thereof.
  • the inner skin layer includes the same resin as the intermediate layer with which the inner skin layer contacts and the resin layer on the surface of the lid on the inner skin layer side, thereby enhancing the adhesion between these layers.
  • the polyethylene-based resin is a resin containing a repeating unit of an ethylene group in a polymer main chain of 30 mol% or more, 40 mol% or more, 50 mol% or more, 60 mol% or more, 70 mol% or more, or 80 mol% or more.
  • low density polyethylene LDPE
  • linear low density polyethylene LLDPE
  • medium density polyethylene MDPE
  • high density polyethylene HDPE
  • EAA ethylene-acrylic acid copolymer
  • EAA ethylene-methacrylic Acid copolymer
  • EAA ethylene-ethyl acrylate copolymer
  • EMA ethylene-methyl acrylate copolymer
  • EVA carboxylic acid modified polyethylene
  • EVA carboxylic acid modified ethylene vinyl Acetate copolymer and Derivatives of al, as well as selected from the group consisting of mixtures.
  • the thickness of the inner skin layer is preferably 5 ⁇ m or more, 10 ⁇ m or more, or 20 ⁇ m or more, and preferably 100 ⁇ m or less, 70 ⁇ m or less, 50 ⁇ m or less, or 40 ⁇ m or less.
  • outer skin layer examples of the resin constituting the outer skin layer include polyethylene resins, polypropylene resins, saturated or unsaturated polyesters, polyvinyl chloride (PVC), polystyrene, and derivatives thereof, and mixtures thereof.
  • PVC polyvinyl chloride
  • the outer skin layer contains the same resin as the intermediate layer, thereby enhancing the adhesion with the intermediate layer.
  • the thickness of the outer skin layer is preferably 5 ⁇ m or more, 10 ⁇ m or more, or 20 ⁇ m or more from the viewpoint of obtaining appropriate moldability and elasticity, and is preferably 100 ⁇ m or less, 70 ⁇ m or less, 50 ⁇ m or less, or 40 ⁇ m or less. .
  • the intermediate layer In the intermediate layer, an inorganic absorbent is dispersed in a binder resin.
  • the intermediate layer functions as an absorption layer that absorbs moisture and organic components in the blister pack.
  • inorganic absorbents that can be used in the intermediate layer include chemical adsorbents such as calcium oxide, calcium chloride, calcium sulfate, magnesium sulfate, and sodium sulfate, and physical adsorbents such as aluminum oxide, quicklime, silica gel, and inorganic molecular sieves.
  • inorganic molecular sieves include, but are not limited to, aluminosilicate minerals, clays, porous glass, microporous activated carbon, zeolite, activated carbon, or compounds having an open structure capable of diffusing small molecules such as water.
  • Such an inorganic absorbent can obtain high hygroscopicity even in a low humidity region, and absorbs moisture slightly contained in the blister pack, even in such a low relative humidity environment. It is particularly preferable to use an absorbent that can exhibit high absorbability.
  • Zeolite As the zeolite, natural zeolite, artificial zeolite, synthetic zeolite or the like can be used. Zeolite is a porous granular material used to separate substances according to the difference in molecular size, and has a structure with uniform pores. Therefore, water (steam, water vapor), organic gas, etc. can be absorbed.
  • An example of a synthetic zeolite is a molecular sieve. Among these, a molecular sieve having a pore (absorption port) diameter of 0.3 nm to 1 nm can be used.
  • molecular sieves having pore sizes of 0.3 nm, 0.4 nm, 0.5 nm, and 1 nm are referred to as molecular sieve 3A, molecular sieve 4A, molecular sieve 5A, and molecular sieve 13X, respectively.
  • the average particle size of the molecular sieve is, for example, about 10 ⁇ m. In the present invention, these zeolites can be properly used in accordance with the object to be absorbed and the properties of the contents.
  • hydrophobic zeolite when absorbing odor, it is preferable to use hydrophobic zeolite because organic gas is often the causative substance.
  • Hydrophobic zeolite is a generic term for a so-called high silica zeolite in which aluminum atoms in the crystal skeleton of the zeolite are reduced by dealumination to increase the silica-alumina ratio.
  • Hydrophobic zeolite is a zeolite that loses its affinity for polar substances such as water and absorbs nonpolar substances more strongly, and more easily absorbs organic gases and the like.
  • hydrophobic molecular sieve which is an example of the hydrophobic zeolite
  • those having a pore diameter of 0.6 to 0.9 nm can be used, and examples thereof include Abscents 1000, Abscents 2000, Abscents 3000 (manufactured by Union Showa Co., Ltd.) and the like.
  • the pore diameter can be confirmed by structural analysis by X-ray diffraction.
  • the average particle size of the hydrophobic zeolite is, for example, 3 to 5 ⁇ m.
  • the inorganic absorbent is 5% by weight or more, 10% by weight or more, 20% by weight or more, 30% by weight or more, 40% by weight or more, or 50% by weight or more based on the weight of the intermediate layer. In the range of 90% by weight, 80% by weight, 70% by weight or less, or 60% by weight or less in the intermediate layer from the viewpoint of dispersibility in the binder resin and moldability. Can be included.
  • the inorganic absorbent can be 5% by volume or more, 10% by volume or more, 20% by volume or more, or 30% by volume or more, 70.0% by volume or less, 65% by volume or less, 60% by volume or less, It can be 55 volume% or less, or 50 volume% or less.
  • the specific gravity of the layer is obtained by measurement, the measured value, the inorganic absorbent and
  • the volume% of the inorganic absorbent may be determined from the added weight of the thermoplastic resin and the specific gravity of the thermoplastic resin. For example, when the specific gravity of a layer formed using 50 g of an inorganic absorbent and 50 g of a thermoplastic resin having a specific gravity of 0.9 g / cm 3 is 1.1 g / cm 3 , it is included in the layer.
  • the inorganic absorbent can be calculated to have a specific gravity of 1.41 g / cm 3, and it can be said that 38.9% by volume is present in the layer.
  • the inorganic absorbent may be contained in the inner skin layer and / or the outer skin layer, but considering the moldability of these layers and the ease of bonding with other layers, etc., it is 40% by volume or less. 30 volume% or less, 28.8 volume% or less, 20 volume% or less, 10 volume% or less, or 5 volume% or less.
  • binder resin examples include polyethylene resins, polypropylene resins, saturated or unsaturated polyesters, ionomers, polyvinyl chloride (PVC), polystyrene, and derivatives thereof, and mixtures thereof.
  • the thickness of the intermediate layer is preferably 20 ⁇ m or more, 30 ⁇ m or more, or 40 ⁇ m or more from the viewpoint of absorption capacity, moldability, and elasticity, and is 500 ⁇ m or less, 300 ⁇ m or less, 200 ⁇ m or less, 150 ⁇ m or less, or 100 ⁇ m or less. It is preferable.
  • the laminated body for blister packs of this invention has said base material layer by the side of the outer skin layer of said absorption layer and said absorption layer.
  • the laminated body for blister packs of this invention has an aluminum layer between an absorption layer and a base material layer.
  • the laminate 10 for blister packs of the present invention has a base material layer 2, an aluminum layer 3, and an absorption layer 4.
  • a known laminating method such as dry lamination or extrusion lamination can be used.
  • the resin used for the base material layer is not particularly limited as long as it provides a suitable moldability to the blister pack laminate.
  • polypropylene resins, polyamides, and polyethylene terephthalate are particularly preferable.
  • the thickness of the base material layer is preferably 10 ⁇ m or more, 20 ⁇ m or more, or 30 ⁇ m or more, and preferably 300 ⁇ m or less, 200 ⁇ m or less, or 100 ⁇ m or less.
  • the aluminum layer is used for imparting barrier properties. This may be a pure aluminum-based aluminum foil or an aluminum alloy-based aluminum foil.
  • the thickness of the aluminum layer is preferably 7 ⁇ m or more, 10 ⁇ m or more, or 20 ⁇ m or more, and 60 ⁇ m or less, 50 ⁇ m or less, or 40 ⁇ m or less in order to give appropriate moldability and elasticity to the blister pack laminate.
  • a reinforcement layer is used in order to improve the moldability of the laminated body for blister packs.
  • This may consist of polyvinyl chloride, saturated or unsaturated polyesters (eg polyethylene terephthalate, polybutylene terephthalate), polyamides and mixtures thereof.
  • the thickness of the reinforcing layer is preferably 15 ⁇ m or more, or 25 ⁇ m or more, and is 60 ⁇ m or less, or 50 ⁇ m or less.
  • the reinforcing layer described in Patent Document 3 can be used as the reinforcing layer.
  • the laminated body for blister packs of the present invention includes a printed layer, an anchor coat layer for enhancing adhesion between two layers, a primer layer, between any two layers of a base material layer, an aluminum layer, a reinforcing layer, and an absorbent layer. You may have.
  • the blister pack of this invention has said laminated body for blister packs, and a cover material.
  • the laminate and the lid material are at least partially adhered, and in particular, when the two outermost layers of the above-described blister pack laminate are the inner skin layer of the base material layer and the absorbent layer, the lid material is the inner skin layer.
  • Glue. Blister pack that contains the contents in the pocket part of the blister pack by forming the pocket part for storing the contents in the blister pack laminate and then storing the contents in the pocket part and bonding the lid material A package can be produced.
  • the lid member includes a resin layer, and further includes an aluminum layer different from the aluminum layer that may be included in the above-described blister pack laminate.
  • “another aluminum layer” may be the same material and thickness, that is, the same aluminum layer may be present in each of the blister pack laminate and the lid. is doing.
  • the resin of the resin layer is selected from the group consisting of polypropylene resin, polyvinyl chloride, ethylene vinyl acetate copolymer, and mixtures thereof.
  • the lid member has a form in which an aluminum layer is coated with a resin layer.
  • the resin layer of the lid member and the layer (inner skin layer) to which the laminated body for blister packs adheres contain the same resin from the viewpoint of enhancing the adhesiveness.
  • the contents of the blister pack of the present invention are not limited as long as they can be deteriorated by contact with the outside air, and examples thereof include drugs, foods, cosmetics, medical devices, electronic parts and the like. Moreover, as a chemical
  • FIG. 1 is a schematic view of a blister pack 1 with an absorbent layer.
  • a lid material 5 is bonded to a blister pack laminate 10 in which a base material layer 2, an aluminum layer 3, and an absorbent layer 4 are laminated in order, and a dome-shaped pocket formed in the laminate 10
  • the content 100 is included in the part.
  • the layers are laminated by a dry lamination method, there are adhesive layers between the base material layer and the aluminum layer and between the aluminum layer and the absorption layer.
  • FIG. 2 is a schematic diagram of the layer structure of the blister pack of the present invention.
  • the end portion of the blister pack where the pocket portion is not formed is shown.
  • the blister pack laminate 10 in which the base material layer 2, the aluminum layer 3, and the absorbent layer 4 are laminated in this order.
  • the lid 5 is adhered.
  • the absorbent layer 4 includes an outer skin layer 41, an intermediate layer 42, and an inner skin layer 43, and the lid member includes a resin layer 51 and an aluminum layer 52.
  • the laminate 10 is formed with a pocket portion for accommodating the contents.
  • Example creation> The laminated bodies for blister packs of Examples 1 to 4 and Comparative Examples 1 to 5 were changed to only the configuration of the inner skin layer, and were configured as shown in Table 1 and Table 2 below.
  • the material of each layer is put into a twin-screw kneading extruder (PCM-30 manufactured by Ikekai Co., Ltd.), kneaded while heating and melting the resin, and then extruded into a pellet to cool.
  • the outer skin layer pellet, the intermediate layer pellet, and the inner skin layer pellet were obtained.
  • a film serving as an absorption layer was formed by coextrusion molding using an inflation molding method. Inflation molding was performed with a three-layer inflation molding machine (3SOIB, Placo Corporation) at a resin temperature of 180 ° C. and a take-up speed of 13 m / min.
  • the base layer, the aluminum layer, the reinforcing layer, and the outer skin layer of the absorption layer were all laminated by a dry lamination method.
  • a urethane-based adhesive Takelac TM and Takenate TM
  • the coating amount of the adhesive between each layer was 5 g / m 2 .
  • ⁇ Evaluation 1 Surface roughness> The surface roughness (arithmetic mean roughness Ra) of the surface on the side opposite to the intermediate layer of the inner skin layer of the laminate for blister packs of Examples 1 to 4 and Comparative Examples 1 to 5 was determined according to ISO 4287. Measurement was performed using a thickness measuring machine (ET4000AK, Kosaka Laboratory Ltd.). An R2 ⁇ m needle tip, apex angle of 60 °, and a diamond stylus were used. The results for the arithmetic average roughness Ra of the inner skin layer are shown in FIG.
  • the surface roughness is large and the slip property is high when HDPE is contained in less than 75 parts by weight.
  • the surface roughness is low and the slipperiness is also low.
  • this is considered to be because HDPE has a high density and therefore has low compatibility with PP, and when these are blended, a sea island structure is formed and the surface is roughened.
  • the maximum indentation depth that can be formed was evaluated.
  • the test is performed 10 times for each depth of each example, and when the appearance is not visually observed such as cracks, scratches, dents, etc. in the pockets formed by all 10 times, the conditions under which molding is possible It was.
  • the test results are shown in FIG.
  • the laminate (Comparative Example 1) including a conventional LLDPE 100% inner skin layer has a low maximum indentation depth of 4.75 mm.
  • produced in the shoulder part of the dome shape of a pocket and the maximum indentation depth became 4.75 mm.
  • the thickness of the top surface portion is not thin, it is considered that the plug and the surface of the laminate are not slipped at the time of molding, and an excessive load is applied to the shoulder portion.
  • the laminate including the inner skin layers of Examples 1 to 4 having high slip properties the maximum indentation depth was 5.50 mm or more.
  • the laminated body (comparative example 5) containing PP100% of inner skin layers was favorable in slip property, the moldability was as low as 5.00 mm. This is presumably because the elastic modulus of PP is lower than that of HDPE, and the force that stretches the inner skin layer during molding is transmitted non-uniformly to the aluminum layer, resulting in molding defects such as cracks.
  • the laminated body for blister packs using the absorbent layer of the present invention deep pockets can be formed, and the blister packs using the same are stable for a long period of time (inhibition of alteration). Can be stored at.

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Abstract

L'objectif de la présente invention est de fournir une couche absorbante destinée à des emballages-coques, qui confère une aptitude au formage suffisante et qui ne crée pas de défauts de formation même si une poche est formée à une certaine profondeur. Une couche absorbante destinée à des emballages-coques selon la présente invention comprend, séquentiellement, une couche de revêtement externe, une couche intermédiaire contenant un absorbant inorganique et une résine liante, et une couche de revêtement interne contenant du polyéthylène haute densité et une résine de polypropylène, en respectant cet ordre, et satisfait au moins à l'une des conditions a) à c) suivantes. (a) La couche de revêtement interne contient de 3 à 70 % en poids d'un polyéthylène haute densité et de 97 à 30 % en poids d'une résine de polypropylène. (b) La rugosité moyenne arithmétique (Ra) d'une surface de la couche de revêtement interne telle que déterminée selon la norme ISO 4287, ladite surface étant sur le verso de la surface latérale de la couche intermédiaire, est supérieure ou égale à 0,40 µm. (c) Le coefficient de frottement cinétique entre la couche de revêtement interne et un polyéthylène ultra-haute densité tel que déterminé selon la norme ISO 8295 est inférieur ou égal à 0,200.
PCT/JP2015/067659 2014-06-18 2015-06-18 Couche absorbante pour emballages-coques, stratifié comprenant celle-ci et emballage-coque utilisant ledit stratifié WO2015194645A1 (fr)

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JP2017119533A (ja) * 2015-12-28 2017-07-06 共同印刷株式会社 ブリスターパック用積層体、及びそれを用いたブリスターパック
JP2017214143A (ja) * 2016-05-31 2017-12-07 共同印刷株式会社 ブリスターパック用積層体、及びそれを用いたブリスターパック
CN113518710A (zh) * 2019-03-28 2021-10-19 积水化成品工业株式会社 层叠发泡片
WO2022097658A1 (fr) * 2020-11-06 2022-05-12 出光ユニテック株式会社 Stratifié et récipient
WO2024043910A1 (fr) * 2022-08-26 2024-02-29 Zeus Company Inc. Tubes revêtus par immersion dans un pe-uhmw

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JP7351777B2 (ja) * 2020-03-16 2023-09-27 株式会社Ｕａｃｊ製箔 アルミニウム積層体、包装材、及びプレススルーパッケージ

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JP2011255931A (ja) * 2010-06-09 2011-12-22 Kohjin Co Ltd 二軸延伸ナイロンフィルムを含む冷間成形用プレススルーパック包材
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JP2012206776A (ja) * 2011-03-30 2012-10-25 Kyodo Printing Co Ltd 蓋材，包装容器及び包装体

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JPS61190460A (ja) * 1985-02-06 1986-08-25 出光石油化学株式会社 ブリスタ−包装体
JP2005523188A (ja) * 2002-04-25 2005-08-04 ハネウェル・インターナショナル・インコーポレーテッド ブリスター包装
JP2004224430A (ja) * 2003-01-27 2004-08-12 Sumitomo Bakelite Co Ltd Ｐｔｐ包装用シート
JP2011255931A (ja) * 2010-06-09 2011-12-22 Kohjin Co Ltd 二軸延伸ナイロンフィルムを含む冷間成形用プレススルーパック包材
WO2012029899A1 (fr) * 2010-09-01 2012-03-08 アステラス製薬株式会社 Emballage
JP2012206776A (ja) * 2011-03-30 2012-10-25 Kyodo Printing Co Ltd 蓋材，包装容器及び包装体

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017119533A (ja) * 2015-12-28 2017-07-06 共同印刷株式会社 ブリスターパック用積層体、及びそれを用いたブリスターパック
JP2017214143A (ja) * 2016-05-31 2017-12-07 共同印刷株式会社 ブリスターパック用積層体、及びそれを用いたブリスターパック
CN113518710A (zh) * 2019-03-28 2021-10-19 积水化成品工业株式会社 层叠发泡片
WO2022097658A1 (fr) * 2020-11-06 2022-05-12 出光ユニテック株式会社 Stratifié et récipient
WO2024043910A1 (fr) * 2022-08-26 2024-02-29 Zeus Company Inc. Tubes revêtus par immersion dans un pe-uhmw

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