JP7038569B2 - Laminates for blister packs and blister packs using them - Google Patents

Description

The present invention relates to a laminate for a blister pack and a blister pack using the same.

The powdery formulation is enclosed in a thin paper bag or film bag, and the formulation such as tablets or capsules is enclosed in a blister pack called PTP (press-through pack). By pushing the pharmaceutical product encapsulated in PTP with a finger, the sheet-shaped lid material can be broken and the pharmaceutical product can be taken out. In addition, the pharmaceutical product may be enclosed in a blister pack having a shape in which two barrier laminated bodies having a molded pocket portion for accommodating the pharmaceutical product are faced to each other and sealed. In the case of this form, the end portion of the blister pack is cut off and opened, or the blister pack is peeled off between the two laminates and opened, so that it can be used as a powdery or liquid formulation.

The pharmaceutical product may change its medicinal properties by absorbing water. Therefore, conventionally, a desiccant such as silica gel is enclosed in an outer bag that encloses a blister pack. However, the work of putting the desiccant in the outer bag is troublesome, and there is a risk of accidental ingestion or accidental ingestion of the desiccant. Further, after the outer bag is opened, the inside of the blister pack cannot be kept at a low humidity, and there is a problem that the deterioration of the pharmaceutical product progresses. Further, depending on the formulation, there are those that are easily oxidatively decomposed and those that emit a peculiar odor, so there is also a request to absorb gases such as oxygen and odor in the blister pack.

On the other hand, Patent Document 1 discloses a technique for improving the long-term stability of a pharmaceutical product by forming a hygroscopic layer having a desiccant inside the blister pack. Here, first, a dome-shaped pocket portion is formed in the laminated body of the base material which is the barrier layer and the moisture absorbing layer. Then, a pharmaceutical product, which is a tablet, is placed in the pocket portion and sealed with a lid material. According to this technique, it is considered possible to maintain a dry state, prevent oxidation, and efficiently remove odors without including a desiccant or the like in the outer bag. Further, the hygroscopic layer described in Patent Document 1 has a three-layer structure composed of a main hygroscopic layer sandwiched between two sub-hygroscopic layers, and by incorporating a large amount of a desiccant in the main hygroscopic layer, moldability is formed. Can have very high hygroscopic performance while maintaining.

Some formulations are sensitive to ultraviolet rays, and if the packaging container is transparent, the medicinal properties may deteriorate. On the other hand, for example, Patent Document 2 discloses a technique for forming an aluminum foil layer not only on a lid material on the back side of a blister pack but also on a laminate for a blister pack on the front side, that is, a so-called aluminum blister package. The aluminum blister package has a very high barrier property because it contains an aluminum foil layer, but the contents cannot be visually recognized.

Patent Document 3 discloses a laminate for a blister pack, which includes a moisture blocking layer. Patent Document 3 states that since the moisture blocking layer blocks moisture inside the blister pack, the odor generated when the pharmaceutical product is decomposed or deteriorated due to the influence of moisture can be effectively suppressed. As the moisture blocking layer, a relatively thick film of cyclic polyolefin and a relatively thin film of a fluororesin are disclosed.

In addition, Patent Document 4 discloses that a polymer film having a clay coating film has a high water vapor barrier property. Further, Patent Document 5 discloses a clay self-supporting film containing clay particles.

International Publication No. 2006/115264 International Publication No. 2012/0292323 Japanese Unexamined Patent Publication No. 2016-55639 Japanese Unexamined Patent Publication No. 2012-240868 Japanese Unexamined Patent Publication No. 2005-313604

An object of the present invention is to provide a blister pack laminate capable of visually recognizing the contents and maintaining an extremely high barrier property for a long period of time, and a blister pack using the laminate. do.

The present inventors have found that the above-mentioned problems can be solved by the present invention having the following aspects.
<< Aspect 1 >>
A transparent laminate for a blister pack containing a first barrier film, a second barrier film, and an absorbent film in this order.
<< Aspect 2 >>
The transparent laminate according to aspect 1, wherein the water vapor transmission rate for 24 hours under a 40 ° C./90% RH environment is less than 0.20 g / m ² .
<< Aspect 3 >>
Each of the first barrier film and the second barrier film is a polymer film having a water vapor barrier layer selected from the group consisting of an inorganic oxide vapor deposition film, a clay coating film, a polyvinylidene chloride coating film, and a polyvinylidene fluoride coating film. Or a water vapor barrier property selected from the group consisting of ethylene-vinyl alcohol polymers, polyvinylidene chloride, polyvinylidene fluoride, polychlorotrifluoroethylene, polytetrafluoroethylene, cyclic olefin polymers and mixtures thereof, and clay particles. The transparent laminate according to aspect 1 or 2, which is a film containing a material.
<< Aspect 4 >>
The transparent laminate according to embodiment 3, wherein one of the first barrier film and the second barrier film is selected from the polymer film having the water vapor barrier layer, and the other is selected from the film containing the water vapor barrier material. body.
<< Aspect 5 >>
The transparent laminate according to any one of aspects 1 to 4, wherein at least one of the first barrier film and the second barrier film is a polymer film having a clay coating film or a clay self-supporting film.
<< Aspect 6 >>
One of aspects 1 to 5, wherein the absorbent film includes an outer skin layer on the second barrier film side, an absorbent holding layer having an absorbent and a binder resin, and a heat-sealable inner skin layer in this order. The transparent laminate according to the section.
<< Aspect 7 >>
The transparent laminate according to any one of aspects 1 to 6, further comprising a base film on the outside of the first barrier film.
<< Aspect 8 >>
A blister pack in which the contents are stored between the transparent laminate according to any one of aspects 1 to 7 in which the pocket portion is formed and the barrier lid material.
<< Aspect 9 >>
The two transparent laminates according to any one of aspects 1 to 7 in which the pocket portion is formed are adhered to each other with the absorption layers facing each other, and the contents are stored in the pocket portion. , Blister pack.

It is a schematic diagram of the blister pack of this invention. It is a schematic diagram which shows another example of the blister pack of this invention.

《Transparent laminate》
The transparent laminate for a blister pack of the present invention contains a first barrier film, a second barrier film, and an absorbent film in this order.

As used herein, the term "transparent" is sufficient as long as the contents are transparent enough to be visually recognized, and includes so-called "semi-transparent". Therefore, the transparent laminate of the present invention does not contain an opaque layer such as aluminum foil.

The present inventors have found that an extremely high barrier property can be maintained for a long period of time by using at least two barrier films in a transparent laminate for a blister pack that does not contain aluminum foil.

In a blister pack laminate in which pockets for storing contents such as pharmaceutical products are formed, cracks may occur in the barrier film when the pockets are formed. In this case, as in the case of the prior art, when there is only one barrier film, moisture easily enters from the crack, whereas as in the laminated body of the present invention, two or more. When the barrier film of No. 1 is used in combination, even if a crack occurs in one barrier film, it is considered that moisture does not easily enter from the crack due to the presence of the other barrier film.

For example, as shown in FIG. 1, the transparent laminate 10 for a blister pack of the present invention has an optional base film 1, a first barrier film 2, a second barrier film 3, and an optional reinforcing film 4 as an outermost layer. , And the absorbent film 5 to be adhered to the lid 6 in this order, or are configured in this order. When the base film 1 is not present, the first barrier film may be the outermost layer. Further, a layer different from the absorbent film 5 may be present for adhering to the lid material 6.

In the present specification, the "laminate composed of A and B" essentially means a laminate containing only the A layer and the B layer, but in addition to the A layer and the B layer, the present invention It means that other layers may be included as long as the advantageous effects of the invention can be obtained or the advantageous effects are not lost. For example, even if an anchor coat layer or the like is included between the A layer and the B layer, it may be expressed as "a laminated body composed of the A layer and the B layer".

Examples of the method of laminating the above films include a dry laminating method and a sandwich laminating method. The dry laminating method is a method in which an adhesive is applied, dried, and then pressurized to cure the adhesive and then bonded. Further, the sandwich laminating method is a method of extruding and bonding a resin constituting each melted layer or an adhesive resin between a base material and a film on the side to be bonded.

The transparent laminate for the blister pack may be formed with a pocket portion for storing the contents such as a pharmaceutical preparation. Examples of the molding method for molding the pocket portion include a flat plate type pneumatic forming method, a plug assisted pneumatic forming method, a drum type vacuum forming method, and a plug forming method. Among these, a plug molding method using a columnar rod (plug material) having a rounded tip of an ultra-high molecular weight polyethylene resin having a viscosity average molecular weight of 1 million or more is preferable for forming a pocket.

The depth of the pocket portion may be 3.0 mm or more, 3.5 mm or more, 4.0 mm or more, 4.5 mm or more, 5.0 mm or more, or 5.5 mm or more, 7.0 mm or less, 6. It may be 5 mm or less, 6.0 mm or less, 5.5 mm or less, or 5.0 mm or less.

The transparent laminate of the present invention may have a thickness of 30 μm or more, 50 μm or more, 80 μm or more, 100 μm or more, 150 μm or more, 200 μm or more, or 300 μm or more, and may have a thickness of 500 μm or less, 400 μm or less, 300 μm or less, 250 μm or less, 200 μm. Hereinafter, the thickness may be 150 μm or less, or 100 μm or less.

(Barrier film)
The types of the first barrier film and the second barrier film are not particularly limited as long as they have a barrier property against water vapor and the like and can provide the advantageous effects of the present invention. In the transparent laminate of the present invention, another film may be present between the first barrier film and the second barrier film, or the first barrier film with or without an adhesive. And the second barrier film may be bonded together.

The water vapor permeability of each of the first barrier film and the second barrier film for 24 hours under the 40 ° C./90% RH environment specified in JIS K7129 is 1.50 g / m ² or less and 1.00 g / m. ² or less, 0.80 g / m ² or less, 0.60 g / m ² or less, 0.50 g / m ² or less, or 0.30 g / m ² or less, 0.10 g / m ² or more, 0 It may be .30 g / m ² or more, 0.50 g / m ² or more, or 0.70 g / m ² or more.

The water vapor transmission rate of the laminate containing the first barrier film and the second barrier film for 24 hours under the 40 ° C./90% RH environment specified by JIS K7129 is 0.50 g / m2 or less, 0.30 g. It may be less than / m2, 0.20 g / m2 or less, less than 0.20 g / m2, 0.15 g / m2 or less, or 0.10 g / m2 or less, 0.01 g / m2 or more, 0.05 g / m2. As mentioned above, it may be 0.07 g / m2 or more, or 0.10 g / m2 or more. In this case, the above-mentioned laminate may be a laminate in which the first barrier film and the second barrier film are bonded together with or without an adhesive, or the transparent laminate of the present invention. It may be.

For example, the first barrier film and the second barrier film may be polymer films having the same or different water vapor barrier properties. Examples of such a film include a polymer film having a water vapor barrier layer and a film containing a water vapor barrier material.

The water vapor barrier layer is not particularly limited as long as it has transparency and water vapor barrier properties, but is, for example, an inorganic oxide thin-film film, an alumina thin-film film, a silica-alumina binary film, or the like. ), Clay coating film, polyvinylidene chloride coating film, polyvinylidene fluoride coating film and the like. The polymer film on which the water vapor barrier layer is formed is not particularly limited as long as it has transparency and can form the water vapor barrier layer, and is, for example, a polyethylene resin, a polyvinyl chloride, a polypropylene resin, a saturated polyester, or a polyamide (for example). , Nylon, Nylon 6, Nylon 6,6, Nylon MXD6) and the like. When the polymer film having the water vapor barrier layer is used as the barrier film, the surface having the water vapor barrier layer may be facing the absorption film side or the opposite side to the absorption film. However, when a polymer film having a water vapor barrier layer is used for the second barrier film, it is preferable that the water vapor barrier layer faces the absorption film side from the viewpoint of reducing the end face deactivation of the absorption film.

Among these, in particular, a polymer film having a polyvinylidene chloride coating film or a polyvinylidene fluoride coating film can be easily and relatively inexpensively obtained, and when forming deep pockets in the transparent laminate of the present invention. It is useful because cracks are unlikely to occur in the film. Further, a polymer film having an inorganic oxide-deposited film (for example, a silica-deposited film, an alumina-deposited film, a silica-alumina binary-deposited film, etc.) is also useful because it can be easily and relatively inexpensively obtained.

As the film containing the water vapor barrier material, the film of the water vapor barrier material is preferably an ethylene-vinyl alcohol polymer, polyvinylidene chloride, polyvinylidene fluoride film, polychlorotrifluoroethylene, polytetrafluoroethylene, cyclic olefin polymer and the like. Examples thereof include a film containing a mixture thereof, a film thereof, and a clay self-supporting film containing clay particles. In addition, when a polymer is referred to in the present specification, a copolymer containing a major repeating unit of the polymer is also included as long as the polymer has a function, and for example, a cyclic olefin copolymer is described above as a cyclic olefin polymer. include.

Preferably, one of the first barrier film and the second barrier film is a polymer film having an inorganic oxide vapor-deposited film, and the other is a film containing a polymer film having a water vapor barrier layer and a water vapor barrier material. Is selected from. While the polymer film having an inorganic oxide-deposited film has a very high barrier property, cracks are likely to occur when pockets are formed, but in the above configuration, it occurs in the inorganic oxide-deposited film. Since the moisture invading from the crack can be barriered by another film, a very high barrier property can be realized.

Further, the polymer film having a clay coating film and the clay self-supporting film containing clay particles can maintain high water vapor barrier properties even if cracks occur when deep pockets are formed in the transparent laminate of the present invention. Therefore, it is useful. Such a film has high heat resistance, flexibility, gas barrier property, and transparency by orienting clay crystals having a thickness of about 1 nanometer and highly laminating them with a water-soluble resin sandwiched between them. Can be done. Specifically, for example, films as described in the above-mentioned Patent Documents 4 and 5 can be mentioned, and as the clay coating film, Lacrain (Daiwa Seikan Co., Ltd.) and the like can be mentioned, and the clay self-supporting film can be mentioned. Can be mentioned as Clay (National Institute of Advanced Industrial Science and Technology).

The first barrier film and the second barrier film may have a thickness of 3 μm or more, 5 μm or more, 8 μm or more, 10 μm or more, 15 μm or more, 20 μm or more, or 30 μm or more, and may have a thickness of 100 μm or less, 80 μm or less, and 60 μm or less, respectively. , 40 μm or less, 30 μm or less, 20 μm or less, or 15 μm or less.

(Absorbent film)
The absorbent film is a film having an absorbent function, and this film can improve the long-term stability of the contents of pharmaceutical preparations and the like. The absorbent film may be a single layer of an absorbent holding layer containing an absorbent and a thermoplastic resin, but preferably an outer skin layer, an absorbent holding layer containing an absorbent and a thermoplastic resin, and an inner skin layer. Include in order. In this case, the absorbent contained in the absorbent retaining layer is prevented from being detached during use, and the absorbent film can be easily manufactured. Therefore, the absorbent is sandwiched between the upper and lower (inner and outer) skin layers.

The outer skin layer is a layer used on the side opposite to the side (outside) where the contents of the blister pack are put, and the inner skin layer is a layer used on the side (inside) where the contents are put.

The absorbent film of the absorbent holding layer single layer can be manufactured by extrusion molding or injection molding such as an inflation method and a T-die method. Further, the absorbent film having a three-layer structure including the outer skin layer, the absorbent retaining layer, and the inner skin layer can be produced by a multilayer inflation method, a T-die method, or the like. This is a method in which a plurality of resins are co-extruded into a tube shape at the same time by a plurality of extruders, and air is blown into the tube to inflate the resin to produce a multilayer film. Further, the absorbent holding layer of the absorbent film is formed into a film or sheet by extrusion molding or injection molding by an inflation method, a T-die method or the like, and the outer skin layer and the inner skin layer are formed into a film by a known method. After that, an absorbent film having a three-layer structure can be manufactured by sandwiching and laminating the absorbent holding layer.

The thickness of the absorbent film may be 50 μm or more, 60 μm or more, or 70 μm or more, and may be 200 μm or less, 100 μm or less, 90 μm or less, or 80 μm or less from the viewpoint of obtaining appropriate moldability and elasticity.

<Absorbent film-skin layer>
The inner and outer skin layers contain primarily resin and may contain a smaller amount of absorbent than the absorbent retaining layer, but the absorbent may be desorbed during the manufacture and use of the blister pack. , And considering the ease of manufacturing the absorbent film, it is preferable that the absorbent film is not contained. Examples of the resin used for the inner skin layer and the outer skin layer include polyethylene-based resin, polypropylene-based resin, polymethylpentene, saturated polyester, polyvinyl chloride, polystyrene, polycarbonate, polyamide, thermoplastic elastomer, and mixtures thereof. Be done.

The thickness of the inner skin layer and the outer skin layer may be 5 μm or more, 10 μm or more, or 20 μm or more from the viewpoint of obtaining appropriate moldability and elasticity, and may be 50 μm or less, 40 μm or less, 30 μm or less, 20 μm or less, or. It may be 15 μm or less.

<Absorbent film-absorbent retaining layer>
The absorbent retaining layer has a structure in which the absorbent is dispersed in the binder resin. The absorbent retaining layer functions as a layer for absorbing water, organic gas and inorganic gas in the blister pack.

The absorbents that can be used for the absorbent retaining layer include inorganic absorbents, such as chemical adsorbents such as calcium oxide, calcium chloride, calcium sulfate, magnesium sulfate and sodium sulfate, and aluminum oxide, quicklime, silica gel and inorganic molecular sieves. Such as physical adsorbents can be mentioned. Examples of inorganic molecular sieves are, but are not limited to, compounds having an open structure capable of diffusing small molecules such as aluminosilicate minerals, clay, porous glass, microporous activated carbon, zeolites, activated carbon, or water. Can be mentioned. Such inorganic absorbers, especially zeolites, can obtain high absorbency even in a low humidity region, and in order to absorb a small amount of moisture contained in the blister pack, such an environment with a low relative humidity can be obtained. However, it is particularly preferable to use an absorbent that can exhibit high absorbency.

From the viewpoint of absorption capacity, the absorbent is more than 0% by weight, 10% by weight or more, 20% by weight or more, 30% by weight or more, 40% by weight or more, or 50% by weight, based on the weight of the absorbent holding layer. In the above range, it can be contained in the absorbent retaining layer, and from the viewpoint of dispersibility in the binder resin and moldability, it is in the range of 70% by weight or less, 60% by weight or less, 50% by weight or less, or 40% by weight or less. Can be included in the absorbent retaining layer.

Binder resins that can be used for the absorbent retaining layer include, for example, polyethylene resins, polypropylene resins, saturated or unsaturated polyesters, ionomers, polyvinyl chloride (PVC), polystyrene, and derivatives thereof, and mixtures thereof. Can be mentioned.

The thickness of the absorbent retaining layer may be 10 μm or more, 20 μm or more, 30 μm or more, or 50 μm or more from the viewpoint of absorbency, moldability, and waist, and may be 500 μm or less, 300 μm or less, 200 μm or less, 150 μm or less, or. It may be 100 μm or less.

(Base film)
The resin used for the optional base film is not particularly limited as long as it is a resin that gives appropriate elasticity and moldability to the blister pack laminate. Examples thereof include polyethylene-based resins, polyvinyl chlorides, polypropylene-based resins, saturated polyesters, polyamides (eg, nylon, nylon 6, nylon 6,6, nylon MXD6), and mixtures thereof. Particularly preferred are polypropylene resins, polyamides and saturated polyesters. The thickness of the base film may be 10 μm or more, 20 μm or more, or 30 μm or more, and may be 300 μm or less, 200 μm or less, 100 μm or less, 50 μm or less, or 30 μm or less.

(Reinforcing film)
The optional reinforcing film is a film used for improving the moldability and the waist of the laminate for blister packs. Examples of the resin used for the reinforcing film include polyethylene resin, polyvinyl chloride, polypropylene resin, polyester (for example, polyethylene terephthalate), polyamide (for example, nylon, nylon 6, nylon 6,6, nylon MXD6), and polyimide. Etc., as well as mixtures thereof. The thickness of the reinforcing film may be 10 μm or more, 15 μm or more, 25 μm or more, 30 μm or more, 40 μm or more, or 50 μm or more, and may be 100 μm or less, 80 μm or less, 60 μm or less, or 50 μm or less.

(Adhesive layer)
The transparent laminate of the present invention may have an adhesive layer between any two of the optional base film, the first barrier film, the second barrier film, the optional reinforcing film, and the absorbent film. Examples of the adhesive that may be used for this adhesive layer include urethane-based adhesives, olefin-based resin adhesives, butyl rubber-based adhesives, acrylic resin-based adhesives, and polyester resin-based adhesives when adhering by the dry laminating method. When the epoxy resin-based adhesive, the silicone resin-based adhesive, or the like is bonded by the sand laminating method, a polyethylene-based resin or the like can be mentioned.

(Blister pack)
The blister pack of the present invention has a transparent laminate for the above-mentioned blister pack and a barrier material. This package can be manufactured by molding the pocket portion into the transparent laminated body and then accommodating the contents in the pocket portion.

The lid material includes, for example, a heat-sealing resin layer and a metal layer. As the heat-sealing resin layer, a thermoplastic resin, for example, a polyolefin-based resin can be used. Further, as the metal layer, an aluminum foil such as a pure aluminum foil or an aluminum alloy foil can be used. Preferably, the lid material is in the form of an aluminum foil coated with a thermoplastic resin layer, and the thermoplastic resin layer of the lid material and the layer (absorbent layer) to which the blister pack laminate adheres have adhesiveness. From the standpoint of enhancing, the same resin can be included. Further, the aluminum foil may be coated with an easy peel resin such as a polyolefin-based polymer alloy, or an easy peel film may be laminated. In this case, the contents can be taken out by peeling off at the adhesive interface between the blister pack and the lid material. Further, the lid material may contain the barrier film described for the above-mentioned transparent laminate instead of the metal layer, and may further contain the base film described for the above-mentioned transparent laminate.

As another aspect of the blister pack of the present invention, two laminates selected from the above transparent laminates are adhered to each other with the absorbent films facing each other, and the contents are stored in the pocket portion. This package can be manufactured by forming a pocket portion into both of the two transparent laminates, then accommodating the contents in the pocket portion, and adhering the absorbent films of the two transparent laminates to each other.

The contents of the blister pack of the present invention are not limited as long as they can be deteriorated by contact with the outside air, and examples thereof include foods, cosmetics, medical devices, electronic parts, and the like, in addition to pharmaceutical products. In addition, the pharmaceuticals include detergents, pesticides and the like, in addition to pharmaceutical formulations.

FIG. 1 is a schematic view of a blister pack 100. Here, the transparent laminate 10 for a blister pack containing the base film 1, the first barrier film 2, the second barrier film 3, the optional reinforcing film 4, and the absorbent film 5 to be adhered to the lid 6 in this order. , The lid material 6 is adhered, and the content 300 is contained in the dome-shaped pocket portion formed in the laminated body 10. Although not shown, an adhesive layer is present between these films as needed.

FIG. 2 is a schematic view of another aspect of the blister pack 200. The absorbent films of the two transparent laminates 10 for blister packs are adhered to each other, and the content 300 is contained in the pocket portion formed in the transparent laminate 10.

The present invention will be described in more detail with reference to the following examples, but the present invention is not limited thereto.

(Making an absorbent film)
As a material for the inner and outer skin layers, resin pellets of linear low density polyethylene (LLDPE) were prepared.

As a material for the absorbent holding layer, an ethylene-methacrylic acid copolymer and a hydrophilic zeolite (Molecular Sheave 3A, manufactured by Union Showa), which is a moisture absorber, were put into a kneading extruder and kneaded while heating and melting the resin. Later, this was extruded with an extruder and cooled to obtain resin pellets for an absorbent holding layer. The content of zeolite in the resin pellet for the absorbent holding layer was 53% by mass by weight of the pellet.

Then, using the resin pellets for the inner and outer skin layers and the resin pellets for the absorbent holding layer, an absorption film having a three-layer structure was formed by coextrusion molding with an air-cooled inflation molding machine. In this absorbent film, the thickness of the inner skin layer and the outer skin layer was 10 μm, and the thickness of the absorbent holding layer was 60 μm.

(Preparation of transparent laminate)
The following barrier films A to C were prepared as the first and second barrier films:
Barrier film A: A 180 μm-thick polyvinyl chloride film coated with polyvinylidene chloride;
Barrier film B: 12 μm thick alumina vapor-deposited PET film (GX-P-F12, Toppan Printing Co., Ltd.); and Barrier film C: 12 μm thick silica-deposited PET film (Tech Barrier HX12, Mitsubishi Chemical Corporation) ..

The first barrier film, the second barrier film, and the absorbent film were laminated in this order by a dry laminating method via an adhesive to obtain transparent laminates of Examples 1 to 3 in Table 1. Further, a transparent laminate of Comparative Example 1 was obtained in the same manner as in Example 1 except that the second barrier film was not used.

(Preparation of sample for evaluation)
A lid material containing 9 μm aluminum foil coated with 12 μm thick polyethylene terephthalate and heat-sealing LLDPE and the surface of the transparent laminate on the absorption film side were heat-sealed to prepare an evaluation sample.

(Moisture absorption rate test)
The evaluation sample was cut into a size of 122 mm × 52 mm, and then the weight was measured promptly, and the initial value was used as the measured value. Then, the evaluation sample was stored in a high temperature and humidity chamber under a 40 ° C./75% RH environment, and the weight was measured over time to observe the amount of moisture absorbed.

The results are summarized in Table 1 below.

Compared with the laminated body of Comparative Example 1, the laminated body of Examples 1 to 3 had an extremely low amount of moisture absorption even on the 8th day.

(Measurement of water vapor transmission rate)
The water vapor transmission rate was measured for the laminate of only the first and second barrier films used in Examples 1 to 3 and the barrier film A used in Comparative Example 1. In this measurement, a moisture permeability measuring device (PERMATRAN-W3 / 33, manufactured by MOCON) was used to obtain the water vapor transmission rate after 24 hours in a 40 ° C./90% RH environment.

This water vapor transmission rate measurement is performed twice, and the average value is summarized in Table 2 below.

1 Base film 2 1st barrier film 3 2nd barrier film 4 Reinforcing film 5 Absorbent film 6 Cover material 10 Transparent laminate 100, 200 Blister pack 300 Contents

Claims (8)

The first barrier film, the second barrier film, and the absorbent film are included in this order.
Each of the first barrier film and the second barrier film is a polymer film having a water vapor barrier layer selected from the group consisting of an inorganic oxide vapor deposition film, a clay coating film, a polyvinylidene chloride coating film, and a polyvinylidene fluoride coating film. Or a water vapor barrier property selected from the group consisting of ethylene-vinyl alcohol polymers, polyvinylidene chloride, polyvinylidene fluoride, polychlorotrifluoroethylene, polytetrafluoroethylene, cyclic olefin polymers and mixtures thereof, and clay particles. It is a film containing a material, and the absorption film is calcium oxide, calcium chloride, calcium sulfate, magnesium sulfate, sodium sulfate, aluminum oxide, fresh lime, silica gel, aluminosilicate mineral, clay, porous glass, microporous activated carbon. Contains an absorbent selected from the group consisting of, zeolite, and activated carbon.
Transparent laminate for blister packs. The transparent laminate according to claim 1, wherein the water vapor transmission rate for 24 hours under a 40 ° C./90% RH environment is less than 0.20 g / m ² . The first or second barrier film, wherein one of the first barrier film and the second barrier film is selected from the polymer film having the water vapor barrier layer, and the other is selected from the film containing the water vapor barrier material. Transparent laminate. The transparent laminate according to any one of claims 1 to 3 , wherein at least one of the first barrier film and the second barrier film is a polymer film having a clay coating film or a clay self-supporting film. Any of claims 1 to 4 , wherein the absorbent film includes an outer skin layer on the second barrier film side, an absorbent holding layer having an absorbent and a binder resin, and a heat-sealable inner skin layer in this order. The transparent laminate according to item 1. The transparent laminate according to any one of claims 1 to 5 , further comprising a base film on the outside of the first barrier film. A blister pack in which the contents are stored between the transparent laminate according to any one of claims 1 to 6 in which a pocket portion is formed and a barrier lid material. The two transparent laminates according to any one of claims 1 to 6 in which a pocket portion is formed are adhered to each other with the absorbent films facing each other, and the contents are stored in the pocket portion. There is a blister pack.

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