WO2006115264A1 - Film for ptp or blister pack, and packaging container for ptp or blister pack - Google Patents

Film for ptp or blister pack, and packaging container for ptp or blister pack Download PDF

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Publication number
WO2006115264A1
WO2006115264A1 PCT/JP2006/308712 JP2006308712W WO2006115264A1 WO 2006115264 A1 WO2006115264 A1 WO 2006115264A1 JP 2006308712 W JP2006308712 W JP 2006308712W WO 2006115264 A1 WO2006115264 A1 WO 2006115264A1
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Patent type
Prior art keywords
ptp
layer
blister pack
film
adsorbent
Prior art date
Application number
PCT/JP2006/308712
Other languages
French (fr)
Japanese (ja)
Inventor
Tatsuya Ogawa
Shinichi Koizumi
Saori Takahashi
Junpei Nakagawa
Original Assignee
Daiichi Sankyo Company, Limited
Kyodo Printing Co., Ltd.
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    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B15/00Layered products comprising a layer of metal
    • B32B15/20Layered products comprising a layer of metal comprising aluminium or copper
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00Layered products comprising a layer of synthetic resin
    • B32B27/18Layered products comprising a layer of synthetic resin characterised by the use of special additives
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00Layered products comprising a layer of synthetic resin
    • B32B27/30Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers
    • B32B27/304Layered products comprising a layer of synthetic resin comprising vinyl (co)polymers; comprising acrylic (co)polymers comprising vinyl halide (co)polymers, e.g. PVC, PVDC, PVF, PVDF
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00Layered products comprising a layer of synthetic resin
    • B32B27/32Layered products comprising a layer of synthetic resin comprising polyolefins
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B27/00Layered products comprising a layer of synthetic resin
    • B32B27/32Layered products comprising a layer of synthetic resin comprising polyolefins
    • B32B27/322Layered products comprising a layer of synthetic resin comprising polyolefins comprising halogenated polyolefins, e.g. PTFE
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B9/00Layered products comprising a particular substance not covered by groups B32B11/00 - B32B29/00
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B9/00Layered products comprising a particular substance not covered by groups B32B11/00 - B32B29/00
    • B32B9/04Layered products comprising a particular substance not covered by groups B32B11/00 - B32B29/00 comprising such particular substance as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B9/041Layered products comprising a particular substance not covered by groups B32B11/00 - B32B29/00 comprising such particular substance as the main or only constituent of a layer, which is next to another layer of the same or of a different material of metal
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B9/00Layered products comprising a particular substance not covered by groups B32B11/00 - B32B29/00
    • B32B9/04Layered products comprising a particular substance not covered by groups B32B11/00 - B32B29/00 comprising such particular substance as the main or only constituent of a layer, which is next to another layer of the same or of a different material
    • B32B9/045Layered products comprising a particular substance not covered by groups B32B11/00 - B32B29/00 comprising such particular substance as the main or only constituent of a layer, which is next to another layer of the same or of a different material of synthetic resin
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/28Articles or materials wholly enclosed in composite wrappers, i.e. wrappers formed by associating or interconnecting two or more sheets or blanks
    • B65D75/30Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding
    • B65D75/32Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents
    • B65D75/36Articles or materials enclosed between two opposed sheets or blanks having their margins united, e.g. by pressure-sensitive adhesive, crimping, heat-sealing, or welding one or both sheets or blanks being recessed to accommodate contents one sheet or blank being recessed and the other formed of relatively stiff flat sheet material, e.g. blister packages, the recess or recesses being preformed
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/24Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants
    • B65D81/26Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators
    • B65D81/266Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants
    • B65D81/267Adaptations for preventing deterioration or decay of contents; Applications to the container or packaging material of food preservatives, fungicides, pesticides or animal repellants with provision for draining away, or absorbing, or removing by ventilation, fluids, e.g. exuded by contents; Applications of corrosion inhibitors or desiccators for absorbing gases, e.g. oxygen absorbers or desiccants the absorber being in sheet form
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00Properties of the layers or laminate
    • B32B2307/70Other properties
    • B32B2307/726Permeability to liquids, absorption
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2307/00Properties of the layers or laminate
    • B32B2307/70Other properties
    • B32B2307/726Permeability to liquids, absorption
    • B32B2307/7265Non-permeable
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2435/00Closures, end caps, stoppers
    • B32B2435/02Closures, end caps, stoppers for containers
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2439/00Containers; Receptacles
    • B32B2439/40Closed containers
    • B32B2439/62Boxes, cartons, cases
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B32LAYERED PRODUCTS
    • B32BLAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT OR NON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM
    • B32B2439/00Containers; Receptacles
    • B32B2439/80Medical packaging

Abstract

Disclosed is a film for a PTP or blister pack wherein the thermal shrinkage rate of a barrier layer serving as the outermost layer and that of a moisture-absorbing layer containing a desiccant are generally equal to each other. Specifically disclosed is a film for a PTP or blister pack, which film has a multilayer structure including an adsorbing layer and a barrier layer serving as the outermost layer. This film is characterized in that the adsorbing layer contains at least one adsorbent selected from the group consisting of physical adsorbents and chemical adsorbents.

Description

Specification

For PTP or blister pack films and PTP or blister pack packaging container

Technical field

[0001] The present invention relates to a film and a packaging container PTP or blister pack of pharmaceutical packaging, and more particularly, to a PTP or Purisuta knocking films and packaging container having an adsorptive which adsorbs moisture and odors etc. .

BACKGROUND

[0002] The pharmaceutical packaging Nio Te,, widely used blister packaging is said to PTP, Ru. Objects or moisture resistance of no or insufficient drugs, even odor is strong agent, it was a number that is charged efficacy of medicines priority to the 巿場. At this time, by using the aluminum foil pyro one bag as the outer bag of the PTP, an adsorbent such as drying agents and 吸臭 agent how to ship it has been taken. However, these adsorbents form bundled, or accidental ingestion mistaken a bag medicine bag of the adsorbent, through the packaging PTP, to guarantee adsorption of such drugs moisture and odors, sub only the following effect could not have been maintained.

[0003] for the purpose of imparting direct drying of the pharmaceutical packaging, PTP with polypropylene, vinyl chloride, To further Noria comprising aluminum force al, and a suction layer this Noria are stacked more formed by kneading the adsorbent packaging has been developed. For example, Patent Document 1, in PTP packaging of medicines packaging, Noria To further comprising polypropylene, discloses a PTP or blister pack films were kneaded desiccant formed by laminating a low-density polyethylene. In such films, but may the drying properties directly applied to the sheet, Noria To more, due to the heat of the difference between the low-density polyethylene, out a difference in shrinkage at the time of heat molding of PTP, molding has occurred is a problem, such as it is difficult.

[0004] Although PTP container obtained by kneading desiccant adhesive for bonding the PTP or blister pack films and aluminum foil have been disclosed (e.g., see Patent Document 2), when taking out the contents of the drug or the like or hardly breaking of aluminum foil side, the area is less hygroscopic capacity of the portion containing the desiccant was a problem such as insufficient to. [0005] Further, for the purpose of adsorbing the odor of drugs, development has been made. For example, the Patent Document 3 and 4, when using a kneaded film 吸臭 agent packaging film, discloses a packaging material which becomes paper strength containing a hydrophobic Zeoraito. Further, Patent Document 5 to 8 disclose containers or the like is contained by kneading the synthetic Zeoraito or activated carbon wood charge. And Kaka article al, previously will adsorbs moisture in the air, a problem that it is impossible to adsorb odors in the dark.

Patent Document 1: JP-T 2003 - 535782 Patent Publication

Patent Document 2: Real Unexamined 5 94167 JP

Patent Document 3: Japanese Patent No. 2538487

Patent Document 4: Japanese Patent No. 2994921

Patent Document 5: JP-A 11 35077 discloses

Patent Document 6: JP-10 16 092 discloses

Patent Document 7: JP 7 22790 JP

Patent Document 8: Registered Utility Model No. 3063963 publication

Disclosure of the Invention

Problems that the Invention is to you'll solve

[0006] The present invention has been made in view of the above problems, provides a PTP or blister pack fill beam was nearly equal thermal shrinkage rate of the hygroscopic layer containing the outermost Noria more To desiccant an object of the present invention is to.

[0007] Further, the present invention, by providing a suction function PTP film shall be the object of providing a use PTP blister exert the function held to drugs film directly and packaging containers.

Means for Solving the Problems

[0008] Film for PTP or blister pack according to the present invention, an adsorption layer, a PTP blister film for the barrier layer is laminated on the outermost layer,

The adsorption layer is characterized by having at least one adsorbent selected group force consisting physical adsorbent and I 匕学 adsorbent.

[0009] Packaging containers for PTP or blister pack according to the present invention, an adsorption layer, a single layer with PTP or packaging container for blister packs stacked film are bonded together to the substrate a barrier outermost layer,

The adsorption layer is characterized by having at least one adsorbent selected group force consisting physical adsorbent and I 匕学 adsorbent.

Effect of the invention

[0010] According to the present invention, by providing a component adsorption function such as moisture and odor ΡΤΡ film, can be provided ΡΤΡ or blister pack films and packaging container is a packaging material for preventing the ingestion accident It became.

[0011] Furthermore, it has become possible to distribute the free immediately packaged products that drying the drug immediately prior to packaging. Thereby, it becomes possible to provide a fill arm and its packaging container ΡΤΡ or blister pack to reduce the cost of the formulation.

BRIEF DESCRIPTION OF THE DRAWINGS

[0012] FIG. 1 is a schematic cross-sectional view of ΡΤΡ or blister pack film according to the invention.

It is another schematic cross-sectional view of ΡΤΡ or blister pack film according [2] present invention.

3 is a schematic cross-sectional view of ΡΤΡ or packaging containers for blister packs according to the present invention. DESCRIPTION OF SYMBOLS

[0013] for 1 ΡΤΡ or blister pack film

2 adsorption layer

2a main adsorption layer

2b sub adsorption layer

3 Roh rear more

4 substrate

5 contents

BEST MODE FOR CARRYING OUT THE INVENTION

[0014] The present inventors have physical adsorbent and Z or chemical adsorbent adsorbed layer, we have found a film for PTP or blister pack having a barrier layer laminated on the adsorption layer. Thus, it has become possible adsorption layer is heat by shrinkage by including a pigment in a high content is barrier layer equivalent young properly close, also solves problem during heat molding for the value.

[0015] The following describes in detail embodiments of the present invention.

[0016] <Film for PTP or blister pack according to the present invention>

Figure 1 shows a schematic cross-sectional view of a film for PTP or blister pack according to the present invention. PTP or blister pack film 1 according to the present invention, the adsorbent layer 2 containing an adsorbent as the innermost layer, outside air force also consists of the barrier layer 3 which prevents the penetration of moisture, oxygen and the like as the outermost layer. As another aspect of the PTP or blister knocking film according to the invention, Figure 2 shows the alternative schematic cross-sectional view of a film for a PTP or blister pack according to the present invention. According to FIG. 2, the adsorption layer, moisture and odor, etc. (hereinafter, also referred to. As adsorbate) and the main adsorption layer 2a mainly responsible for adsorption of the auxiliary adsorption layer 2b which performs adsorption of adsorbate subsidiarily having. As this, when having the adsorption layer 2 where the film for PTP or blister pack according to the invention consists of a main adsorbent layer 2a and the sub adsorption layer 2b, the content of the adsorbent in the main adsorbent layer, that of the sub-suction layer more than that is preferable. Thus, the efficiency of the adsorption is further improved. In addition, instead of the Fuku吸 adhesive layer, it also provided a layer having a ヽ 榭脂 such containing an adsorbent! ヽ.

[0017] 榭脂 material of the main adsorption layer is a high melt flow rate, and a low melting point (low softening point), it is preferable a 榭脂 excellent in low temperature drawdown. High melt flow rate 榭脂 der lever, also decreased melt flow rate by the addition of adsorbent, it is possible to ensure a certain degree of flow characteristics. Furthermore, if low-melting, by 榭脂 is soft I spoon at low temperatures enables low extrusion avoids the risk of foaming. If 榭脂 superior in low temperature drawdown, it is also easy to extrusion molding by extrusion molding machine as the addition of the adsorbent.

[0018] In particular, when the adsorbate is odor, 榭脂 component of the main adsorption layer, for reasons similar to those described above, is at least one melt flow rate of 10 or more, and low melting point ( Tei軟I 匕点), preferred that a 榭脂 superior in low temperature drawdown.

[0019] The 榭脂 main adsorbent layer from this point of view, for example, LDPE (low density polyethylene), LLDPE (linear low density polyethylene), polymers such as PP (polypropylene) is exemplified al are. Further, ionomers (e.g., salts of ethylene-acrylic acid copolymer), EAA (Echire emissions acrylic acid copolymer), EMAA (ethylene methacrylic acid copolymer), EVA (ethylene acetate Bulle copolymer), EEA (ethylene ethylene Atari rate copolymer), various copolymers such EMA (E Ji Ren methyl Atari rates copolymer) and EMMA (ethylene methyl methacrylate Tari rates copolymer) is (copolymer) and the like. The 榭脂 used mainly adsorbed layer in order to achieve the barriers more To same thermal shrinkage rate in a state containing a pigment at a high content, polypropylene Noria used in more preferred in this onset bright, polypropylene heat shrinkable preferably the near V ,: LDPE and LLDPE to rate! /,.

[0020] 榭脂 material sub adsorption layer mainly adsorbed layer of polypropylene and a heat shrinkage factor preferably used in the barrier layer in the present invention is equivalent, and equivalent secondary adsorption layer also heat shrinkage sandwiching the main adsorbent layer order to, polypropylene LDPE and LLDPE is preferred! /,.

[0021] adsorption layer in the present invention may be contained art known adsorbents. Examples of these include, for example, such as various molecular sieves, physically adsorbents for adsorbing adsorbate (hereinafter, referred to as "physical adsorbent".) And the like calcium oxide, chemically adsorbate adsorbent to adsorb (hereinafter, referred to as "chemical adsorbent".), and the like.

[0022] Te you, the present invention, the adsorbent due to the adsorption rate and adsorption properties of the adsorbate, the physical adsorbent may be used in combination with the chemical adsorbent. Generally, physical adsorbent, faster adsorption speed. The chemical adsorbent, the adsorbate is adsorbed adsorbate may be less to leave adsorbed. Accordingly, they, and a physical adsorbent and I 匕学 adsorbent in combination child, it is possible to synergistically exhibit the adsorption rate and adsorption properties with respect to the adsorption of moisture and odor. For this reason, among others, it may be configured to contain one or both of Sani匕 calcium is one example of which is an example of a physical adsorbent synthetic Zeoraito and I 匕学 adsorbent.

[0023] Further, the conventional force be an issue, was zeolite or physical desorption of the adsorbent force even in water such as silica gel, when used together with the physical adsorbent and chemical adsorbent, it can be effectively suppressed to become. That is, gradual transition and a layer having a layer with a chemical adsorbent having a physical adsorbent if provided adjacent, to the chemical adsorbent adsorbate such as moisture physical adsorbent had adsorbed is adjacent and, it has become possible to hold without being eliminated even in a high temperature environment.

[0024] Physical adsorbent is a synthetic Zeoraito is the adsorbate for fast adsorption rate can be to iodine faster adsorption. It is an example of a synthetic Zeoraito molecular sieve is a porous particulate material used to separate materials by differences in molecular size, a structure having a uniform pore and into the cavity of the pore It has the effect of one sieve to adsorb small molecules. In the present invention, when using a molecular sieve, its adsorption caliber, 0. 3 nm to: Lnm are preferred. Usually, pore size 0. 3 nm, referred 0. 4 nm, 0. 5 nm, the Moreki Yura one sheave of lnm, each molecular sieve 3A, molecular sieve 4A, Morekyu Rashibu 5A, and molecular sieve 13X. In the present embodiment, Morekyurashi over blanking 3A or molecular sieves 4A are used as suitable adsorbents. The average particle diameter of Moreki Yura one sheave, for example, 10 mu m ones of the front and rear are used.

[0025] If the adsorbate and odor, Oite the film for PTP or blister pack according to the present invention, the adsorption layer may contain a hydrophobic Zeoraito is a type of synthetic Zeoraito. Hydrophobic Zeoraito, aluminum atoms in the crystalline framework of Zeoraito reduced by treatment dealuminated, increasing the silica-alumina ratio, collectively referred also to was a so-called high silica zeolites. With hydrophobic Zeoraito lose affinity for polar substances such as water, a zeolite to adsorb more strongly polar substances of odor components and the like.

[0026] Te Contact! /, The adsorption layer of the PTP or blister pack film according to the invention, when using a hydrophobic Ze O write, the content thereof, relative to the weight of the adsorbent, with 5-70 wt% there this a force transducer preferred, particularly preferably 10 to 70 wt%. If the content is less than 5 wt%, it is difficult to moldings to obtain sufficient adsorption performance, when 70 wt.%, The molding difficult.

[0027] On the other hand, when the adsorbate with water, in Fi Lum for PTP or blister pack according to the present invention, the adsorbent layer may have a chemical adsorbent. Examples of chemical adsorbent include oxidation of calcium. Chemical adsorbent is generally physically adsorbent than the moisture absorption rate of the above slow adsorbed gradually, there is no separating the adsorbed component Once adsorbed, even when exposed to a high temperature environment no desorption of adsorbate such as water.

[0028] In the film for PTP or blister pack according to the present invention, the adsorbent layer may have a physical adsorbent and chemical adsorbent. If the molecular sieve as a physical adsorbent, was used Sani匕 calcium as chemical adsorbents, the mixing ratio of molecular sieve and Sani匕 calcium, molecular sieve: calcium oxide = 99: 1 to 1: 99 is good Mashigu 90: 1 0-40:! it is more preferable is 60 /,. The molecular sieve (synthetic peptidase O write) is large at this mixing ratio, to the molecular sieve to adsorb moisture up to about 20 wt% of its own weight, since calcium oxide is large and up to about 30 weight 0/0 of its own weight in it can be held without moisture Morekyurashi over blanking is hygroscopic is released in a high temperature environment also goes to Sani匕 calcium.

[0029] Te you, the adsorption layer of the film for PTP or blister pack according to the present invention, the synthetic zeolites with the content of the desiccant calcium oxide, has a preferred instrument particularly preferably from 5 to 70 wt% 30 to 70 percent by weight. If the content is less than 5 wt%, it is difficult molded article to obtain a sufficient drying performance, when 70 wt.%, Molding becomes difficult.

[0030] In the film for PTP or blister pack according to the present invention, when an adsorbing layer in the main adsorbent layer and the sub adsorption layer, moisture, performs the adsorption of adsorbate, such as an auxiliary odor sub intake sealable layer content of the adsorbent, Yogu 5-50 wt% less than the main adsorbent layer primarily responsible for adsorption of the adsorbate is preferred.

[0031] In addition, the adsorption characteristics of the molecular sieve, the pore size are involved, to enhance the adsorption properties of the water, by finer powder molecular sieves, to widen the substantially surface area, pore it is possible to cope with increasing the number of.

[0032] adsorption layer in the present invention is preferably from preferably be contained 30 to 70% by weight of pigment component device comprising an adsorbent is 40 to 70 wt%, more preferably from 45 to 65 wt% . If the content is less than 30 wt.%, Difference in thermal shrinkage between the adsorption layer and the barrier layer is increased, wrinkles or the like occurs during heating molding easily. Also, if 70 wt.%, Molding becomes difficult.

[0033] As the pigment component other than the adsorbent described above, Do have a function such as hygroscopicity and gas adsorption performance, especially, Yo be used pigments, and a variety be contained pigments having these functions such effects can be obtained. As such pigments, calcium carbonate, titanium oxide, zinc oxide, Sani匕 zirconium, alumina, silica, My force, talc, carbon and activated carbon Ru mentioned.

[0034] adsorption layer inflation method and an adsorbent with 榭脂, T-die method, also extruded of coextrusion such formed into a film or sheet by injection molding, in particular inflation method or multilayer film is preferred by the T-die method. Note that the multi-layer inflation method, extruding 榭脂 melted at a plurality of extruders into a tube, inflated by sending air into the a process for producing multilayer films. The structure of the adsorbed layer, two-kind three-layer or three-kind three-layer is preferred.

[0035] The film thickness of the adsorption layer in the present invention is preferably 30 πι~200 / ζ m. The film thickness of the main adsorption layer 10 111-190 111 mosquitoes child preferred, 畐 ^ adsorbing layer 5 111-190 111 mosquitoes child Mashii.

[0036] The Noria material used to more, as long as it has excellent moisture resistance for preventing intrusion of moisture or oxygen from the outside is not particularly limited. For example, polypropylene, Porishioi匕 Bulle, polyethylene terephthalate, polytetramethylene full O b Ethylene (PTFE), aluminum - © beam made thin, and the like, in particular, polypropylene, polyvinyl chloride, polytetra full O b Ethylene (PTFE ), preferred is an aluminum thin film.

[0037] As a method of bonding the adsorbent layer and the barrier layer, a dry lamination method, Sandoramine Shiyon method and extrusion lamination method, and the like. Dry lamination method, after the adhesive is coated fabric was dried, a pressurizing method of bonding to cure the adhesive. Also, push out lamination method is a method of bonding extruded adhesive layer 榭脂 melted at a plurality of extruders. Furthermore, Sandra Mine chromatography Chillon method is a method of bonding extruding 榭脂 for molten moisture layer between the film on the side bonded to the coated substrate with an adhesive.

[0038] adhesion of PTP or blister pack films obtained by combining film thickness, 20 μ m~500 μ m forces Preferably, more preferably 100 μ m~400 μ m. Insufficient Roh rear one and intensity is less than 20 mu m, is taken out of the deformed hardly becomes contents becomes difficult when pressing the PTP contents of the drug or the like too hard exceeds 500 m.

[0039] <PTP or blister pack for the packaging container according to the present invention>

Figure 3 is a schematic cross-sectional view of a packaging container for PTP or blister pack according to the present invention. Packaging container for PTP or blister pack according to the present invention, a PTP or blister pack film 1 formed by laminating a adsorption layer 2 and the barrier layer 3 described above, the adsorption layer 2 laminated base material side 4 of the film with the door. PTP or packaging container for blister packs according to the invention, so as to form a space for accommodating the contents 5 to be made image de adsorbing layer 2 and the substrate 4, a film for P TP or blister packs, substrate 4 and the only to be produced by molding in a suitable molding method such as PTP molding. Note that the contents 5, tablets, capsules, granules, etc. and is not particularly be limited constant.

[0040] As the base material used in the PTP or packaging containers for blister packs according to the present invention is to adequately protect the contents 5 from the outside environment, as it can be laminated to the aforementioned PTP or blister pack film and good good if there is, there is no particular limitation. For example, aluminum foil, and the like. Among them, in view of the extraction of the PTP or packaging containers for blister packs of the contents 5 is preferably aluminum foil.

[0041] As the molding method of the above-mentioned PTP or blister pack packaging container, flatbed pressure forming forms method, plug-assist pressure forming, drum vacuum forming method, and a known PTP molding methods such as plug molding method . For example, PTP or packaging container blister pack according to the invention, for example, first, set the PTP or blister pack films described above into a roll, while 卷出 this, in the downstream portion, a film for PTP or blister pack in a state that was allowed to Caro heat softened, the space for accommodating the contents 5 in this 軟I radical 21-position is defined. Its After using the bonding method such as dry lamination method, PTP or blister pack film and the contents 5 were stacked Surebayo.

Example

[0042] Hereinafter, by way of specific examples the present invention will be described in more detail, the present invention is not limited to these examples.

[0043] (Preparation of master batch - that:! ~)

As a master batch 1 1 (MB1- 1), with respect to molecular sieve 3A in 50 parts by weight, LDPE (trade name: PETROTHENE 204, Tosoh Ltd. one company) was kneaded 50 parts by weight pelletized granular 榭脂It was prepared.

[0044] Masterbatch 1 2 - as (MB1 2), with respect to molecular sieve 3A in 75 parts by weight, LDPE (trade name: Petrocene 204) 25 parts by weight of kneaded to, prepare pellets of granular 榭脂 the did.

[0045] Master batch 1 3 - As (MB1 3), relative to calcium oxide 50 parts by weight, LD PE (trade name: Petrocene 204) were kneaded 50 parts by weight to prepare a pelletized granular 榭脂 by

[0046] as a master batch 1 4 (MB1-4), with respect to molecular sieve 3A in 10 parts by weight of polypropylene (trade name: Novatec PP BC06C, Japan Polypropylene Co., Ltd.) were kneaded 90 parts by weight pellets the Jo granular 榭脂 was prepared.

[0047] Master batch 1 5 - as (MB1 5), with respect to molecular sieve 3A in 75 parts by weight of polypropylene (trade name: Novatec PP BC06C) 25 parts by weight were kneaded to prepare a pelletized granular 榭脂.

[0048] as a master batch 1-6 (MB1- 6), with respect to titanium oxide 50 parts by weight, LDPE (trade name: Petrocene 204) of by kneading 50 parts by weight of titanium oxide ZLDPE = 50Z50 pellet form the granular 榭脂 was prepared.

[0049] as a master batch 1-7 (MB1- 7), in MB1- 6, the mixing ratio of the titanium oxide and the LDPE, except for using Sani匕 titanium ZLDPE = 75Z25, manufactured similarly adjusted as MB1- 6 to prepare a pelletized granular 榭脂.

[0050] as a master batch 1-8 (MB1- 8), with respect to titanium oxide 50 parts by weight, polypropylene (trade name: Novatec PP BC06C) by kneading 50 parts by weight of titanium oxide ZPP = 50

To form a pellet-like granulated 榭脂 of Z50.

[0051] as a master batch 1-9 (MB1- 9), in MB1- 8, the mixing ratio of the titanium oxide and Polypropylene, except for using Sani匕 titanium ZPP = 75Z25, tone like the MB1- 8 papermaking, to prepare a pellet-like granulated 榭脂.

[0052] as a master batch 1 10 (MB1- 10), for the molecular sieve 3A in 60 parts by weight, LDPE (trade name: PETROTHENE 204, Tosoh Ltd. one company) by kneading 40 parts by weight, pellets of the granular 榭脂 was prepared.

[0053] (Example 1 1 1)

As 榭脂 adsorption layer, using only MB1- 1 in the main adsorbent layer, using a secondary adsorption layer MB1- 4 only, to prepare a two-kind three-layer film by a multilayer inflation method. The film thickness of the two-kind three-layer film is a by-hygroscopic layer Z main hygroscopic layer Z sub hygroscopic layer = 5 m / 50 μ να / ΙΟ μ m. Contact name, the content of the pigment with the exception of wicking layer entire desiccant and the desiccant 41 wt%, respectively, 0 by weight%, thus the total pigment containing the desiccant was 41 wt%.

[0054] The resulting surfaces were coarse to corona treatment in order to improve the secondary adsorption layer side of the adhesive of 5 mu m in two-kind three-layer film. The film thickness was released secondary adsorption layer side of 5 m by baked follow thermal shrinkage history 250 μ m ΡΤΡ polypropylene film (trade name: CPPE0025NA, Mitsubishi 榭脂 Co.) PTP or bonded by dry lamination method to obtain a full Ilm for pre-star pack. Then, as put the contents of the blister pack molding machine aluminum foil auxiliary adsorption layer thickness on the side 30 mu m in (CKD (Ltd.)) lines ,, 10 mu of PTP molded by m, dry lamination It was laminated by law to produce a PTP or Purisuta Roh ^ click packaging container configuration as shown below. The numbers of each layer shows a thickness m).

• PP ZZ2 kind three-layer film ZZ aluminum foil

250 65 30

[0055] (Example 1 1 2)

Example 1 1 - Te you, to 1, except for changing the MB1- 1 of the main hygroscopic layer MB1- 2, the same procedure as in Example 1 1 1, to produce a PTP or blister pack packaging container . Contact name in the PTP or packaging containers for blister packs, the content of the pigment with the exception of desiccant and desiccant overall wicking layer, 65 wt%, respectively, 0% by weight, thus the total pigment comprising a drying agent It was 65% by weight.

[0056] (Example 1 1 3)

In Example 1 1 1, in place of the MB1- 1 of the main adsorption layer, MB1- 1 and MB1- 3 and 50: except for using a mixture in a mixing ratio of 50, in the same manner, PTP or Purisuta Roh ^ to produce a click for the packaging container. Incidentally, containing Yuryou pigments except the desiccant moisture layer overall desiccant 41 wt%, respectively, 0% by weight, thus the total pigment containing the desiccant was 41 wt%.

[0057] (Example 1 1 4)

! Example 1 1 3 Contact /, Te, the mixing ratio of the MB1- 1 and MB1- 3 main hygroscopic layer 70: was changed to 3 0, in the same manner as in Example 1- 1- 3, to prepare a PTP or packaging container for a blister pack. The content of the pigment with the exception of the desiccant moisture layer overall desiccant their respective 41 wt%, 0 wt%, thus the total pigment containing the desiccant was 41 wt%

[0058] (Example 1 1 5)

In Example 1 1 1, instead of the two-kind three-layer film, except that to prepare a single layer film having only the main adsorbent layer in the same manner as in Example 1-1-1, PTP or blister pack packaging the vessel was manufactured. The content of the pigment with the exception of wicking layer entire desiccant desiccant, respectively 50 wt%, 0 wt%, thus the total pigment containing the desiccant in dark at 50 wt%.

[0059] (Example 1 1 6)

In Example 1 1 5, MB1- 1 instead, MB1- 1 and MB1- 6 and a 1: except for using a mixture 1 ratio, in the same manner as in Example 1- 1 5 Te, to prepare a PTP or Bliss Tapakku packaging containers. The content of the pigment with the exception of wicking layer entire desiccant and the desiccant 25 wt%, respectively, a 25% by weight, thus the total pigment containing the desiccant was 5 0 wt%.

[0060] (Example 1 1 7)

Example 1 1 - 1 your, Te, of 10 mu m as a by-adsorbent layer LDPE: except for using (trade name Petrocene 20 4) made of layers, in the same manner as in Example 1 1 1, to prepare a PTP or blister Roh ¾ / click for a packaging container. The content of the pigment with the exception of the desiccant moisture layer overall desiccant 45 wt%, respectively, 0% by weight, thus the total pigment containing the desiccant 45 wt% der ivy o

[0061] (Example 1 2- 1-1 2- 4)

Example 1 1- 1~1- 1 4 your! /, Te, is the bonding of the two-kind three-layer film and PTP polypropylene Fi Lum except that dry lamination method forces were also changed to Sandra Mine over Chillon method, performed example 1 1 1-1 1-4 respectively in the same manner as to prepare a packaging container PTP or blister pack.

[0062] (Example 1 3- 1)

In Example 1 1 1, in place of MB1- 1, using MB1- 10, MB1- 4 in cash forte, polypropylene (trade name: Novatec PP BC03C (impact resistance) (manufactured by Japan Polypropylene Corporation;)) the use, the thickness of the two-kind three-layer film as the auxiliary moisture layer Z main hygroscopic layer Z sub hygroscopic layer = 10 m / 5 0 μ m / 10 μ m, and corona treated sub adsorption layer of 10 mu m, film thickness 250 mu instead of the polypropylene film for a PTP m, poly Shioi匕 Bulle having a thickness of 200 m: except for using (trade name bi two foil (Mitsubishi 榭脂 Co.)), example It was carried out in the same manner as 1- 1- 1, PTP or to produce a blister pack films. The content of the pigment with the exception of wicking layer entire desiccant and the desiccant 41 wt%, respectively, 0% by weight, thus the total pigment containing the desiccant was 41 wt%.

[0063] (Example 1 3- 2)

In Example 1 3 1, the thickness of polychlorinated Bulle and 0.99 m, and Phil arm of two-kind three-layer, the bonding between the poly Shioi匕 Bulle, instead of dry laminating method, MB1- except that was carried out by a sand lamination method using 1 were performed in the same manner as in example 1- 3- 1, to prepare a PT P or blister pack films. The content of the pigment with the exception of the desiccant moisture layer overall desiccant, respectively 43 wt%, 0 wt%, thus the total pigment containing the desiccant was 43 wt%.

[0064] (Example 1 4 1)

In Example 1 3 1, instead of polypropylene, and PET with a thickness of 38 m, except for using the film thickness 5 O / zm aluminum (PET), Example

38 ZA150 1- 3- 1 and likewise have rows, to prepare a PTP or blister knocking film. The content of the pigment with the exception of the desiccant moisture layer overall desiccant, respectively 43 wt%, 0 wt%, thus the total pigment containing the desiccant was 43 wt%.

[0065] (Example 1 4 2)

In Example 1 3 2, instead of polypropylene, and polypropylene having a thickness of 38 mu m, except for using the film thickness of the aluminum (PP), Example

It was carried out in the same manner as 50 ZA150 1- 3- 2, to prepare a film PTP or blister pack. The content of the pigment with the exception of the desiccant moisture layer overall desiccant, respectively 43 wt%, 0 wt%, thus the total pigment containing the desiccant was 43 wt%.

[0066] (Example 1 5- 1)

In Example 1 3 1, in place of polychlorinated Bulle having a thickness of 200 m, 50 mu aluminum thin film having a thickness of m (trade name: BESPA (manufactured Sumikei aluminum foil, Ltd.)) was used except were performed in the same manner as in example 1- 3- 1, was manufactured create a film for PTP or blister pack. The content of the pigment with the exception of the desiccant moisture layer overall desiccant, respectively 43 by weight%, 0 wt%, thus the total pigment containing the desiccant was 43 wt%.

[0067] (Example 1 5- 2) Example 1 3 2, 200 in place of polychlorinated Bulle having a thickness of m, an aluminum thin film (trade name having a thickness of 50 μ m: BESPA ( except for using the housing made light aluminum foil, Inc.)) were performed in the same manner as in example 1 3- 2 was manufactured create a film PTP or blister pack. The content of the pigment with the exception of the desiccant moisture layer overall desiccant, respectively 43 by weight%, 0 wt%, thus the total pigment containing the desiccant was 43 wt%.

[0068] (Example 1 6- 1)

In Example 1-4 1, in place of polychlorinated Bulle having a thickness of 200 m, 50 mu aluminum thin film having a thickness of m (trade name: BESPA (manufactured Sumikei aluminum foil, Ltd.)) was used except were performed in the same manner as in example 1-4-1 was manufactured create a film for PTP or blister pack. The content of the pigment with the exception of the desiccant moisture layer overall desiccant, respectively 43 by weight%, 0 wt%, thus the total pigment containing the desiccant was 43 wt%.

[0069] (Example 1 6-2)

In Example 1-4 2, instead of polychlorinated Bulle having a thickness of 200 m, 50 mu aluminum thin film having a thickness of m (trade name: BESPA (manufactured Sumikei aluminum foil, Ltd.)) was used except were performed in the same manner as in example 1-4-2 was manufactured create a film for PTP or blister pack. The content of the pigment with the exception of the desiccant moisture layer overall desiccant, respectively 43 by weight%, 0 wt%, thus the total pigment containing the desiccant was 41 wt%.

[0070] (Comparative Example 1 1 1)

In Example 1 1 1, in place of the film for PTP or blister pack, Rotauro polypropylene film having a thickness of 300 mu m (trade name: CPPE0030NA, Mitsubishi 榭脂 Inc.) except for using only Example 1 - in the same manner as 1-1, to produce a comparison PTP or blister pack packaging container.

• pp ZZ aluminum

300 foil 30

[0071] (Comparative Example 1 1 2)

In Example 1 1 1, instead of the two-kind three-layer film, except that to prepare a single layer film having only a secondary adsorption layer, in the same manner as in Example 1-1-1, PTP or blister pack packaging the vessel was manufactured. The content of the pigment with the exception of the desiccant moisture layer overall desiccant 10 wt%, respectively, 0% by weight, thus the total pigment containing the desiccant was 10 wt%.

[0072] (Comparative Example 1 2 1)

Te you, in Example 1 1 1, the MB1- 1 LDPE (trade name: PETROTHENE 202, manufactured by Higashisoichisha) was changed only, in the same manner as in Example 1 1 1, compared PTP or Purisuta Roh ^ to produce a click for the packaging container. Incidentally, containing Yuryou pigments except the desiccant moisture layer overall desiccant, respectively 2% by weight, 0% by weight, thus the total pigment containing the desiccant was 2 wt%.

[0073] (Comparative Example 1 2 2)

In Example 1- 1- 1, MB1- ^ MB1- 2, the MB1-4 to MB1- 5, except that their respective change, in the same manner as in Example 1 1 1, compared PTP or blister pack the use packaging container was produced. The content of the pigment with the exception of the desiccant moisture layer overall desiccant, respectively 75 wt%, 0 wt%, thus the total pigment containing the desiccant 75 wt% der ivy o

[0074] (Comparative Example 1 2 3)

In Example 1- 1- 1, MB1- ^ MB1- 6, the MB1-4 to MB1- 8, except that their respective change, in the same manner as in Example 1 1 1, compared PTP or blister pack the use packaging container was produced. The content of the pigment with the exception of wicking layer entire desiccant desiccant, respectively 0 wt%, 41 weight%, and thus the total pigment containing the desiccant 41 wt% der ivy o

[0075] (Comparative Example 1 2- 4)

In Example 1 1 1, MB1- 1 to MB1- 6, the MB1- 4 Polypropylene (trade name: Novatec PP FA3EB), the except for changing respectively, and in Example 1 1 1 Similarly Te, to produce a packaging container for comparison PTP or blister pack. The content of the pigment with the exception of wicking layer entire desiccant desiccant, respectively 0 wt%, 38 weight%, and the total pigment containing desiccants Te cowpea was 38 wt%.

[0076] (Comparative Example 1 2 5)

In Example 1- 1- 1, MB1- ^ MB1- 7, the MB1-4 to MB1- 9, except that their respective change, in the same manner as in Example 1 1 1, compared PTP or blister pack the use packaging container was produced. The content of the pigment with the exception of the desiccant moisture layer overall desiccant

, Respectively 0 wt%, a 75% by weight, thus the total pigment containing the desiccant 75 wt% der ivy o

[0077] (Comparative Example 1 2 6)

Example 1 1 - Te you, to 1, instead of MB1- 1, MB1- 6 and LDPE (trade name: Peter Sen 204) and a 30: Change in a mixture in a mixing ratio of 70, MB1- 4 was changed to MB1- 5 a, the same procedure as in example 1 1 1, to produce a comparison PTP or blister Roh ¾ / click for packaging containers. The content of the pigment with the exception of the desiccant moisture layer overall desiccant their respective 17% by weight, and 12% by weight, thus the total pigment comprising a desiccant been filed in 29% by weight.

[0078] (Comparative Example 1 2 7)

In Example 1- 1- 1, MB1- ^ MB1- 9, the MB1-4 to MB1- 5, except that their respective change, in the same manner as in Example 1 1 1, compared PTP or blister pack the use packaging container was produced. The content of the pigment with the exception of wicking layer entire desiccant desiccant, respectively 17 wt%, 58 weight%, and thus the total pigment containing the desiccant in dark at 75 wt%.

[0079] (Comparative Example 1 3)

In Comparative Example 1 1 1, in place of the polypropylene film for a PTP 300 / zm, except for using poly Shioi匕 Bulle film having a thickness of 20 0 mu m, and Comparative Example 1 1- 1 in the same way, to produce a packaging container for comparison PTP or blister pack.

[0080] (Comparative Example 1 4)

Best Web /, in Comparative Example 1 3 Te, instead of polychlorinated Bulle film having a thickness of 200 mu m, a laminate of an aluminum blister film (an aluminum film and a polypropylene film, aluminum - © beam film thickness of There is a 50 mu m, except that the thickness of the polypropylene film was used) of 80 mu m were performed in the same manner as in Comparative example 1 3 was produced packaging containers for comparison PTP or blister pack.

[0081] (Comparative Example 1 5)

Comparative Example 1 3 Contact! /, Te, instead of polychlorinated Bulle film having a thickness of 200 mu m, a laminate of an aluminum blister film (polyethylene film, an aluminum film and a polypropylene film, the thickness of the polyethylene film a There 38 mu m, the film thickness of the aluminum film be 50 mu m

, Except that the thickness of the polypropylene film was used) of 80 / zm were performed in the same manner as in Comparative Example 3 was produced packaging containers for comparison PTP or blister pack.

[0082] and the heat-sealing property between the moldability and the aluminum lid of PTP blister packaging container obtained by the above manufacturing method and evaluated as follows. The results are shown in Tables 1 to 3.

[0083] Evaluation method of moldability,

○: good without wrinkles, etc. depend on the time of PTP molding.

△: occurrence of wrinkles can be seen in part at the time of PTP molding.

X: ΡΤΡ wrinkles or the like occurs at the time of molding defects.

[0084] The evaluation method of heat sealing property,

◎: No peeling on the bonded portion between the aluminum lid.

○: peeling the bonded portion between the aluminum lid free, but peeling easy.

△: peeled off to some of the bonded portion between the aluminum lid.

X: the bonded portion is peeling failure between the aluminum lid.

[0085] In addition, insert the probe of temperature and humidity meter contents are in the sky of ΡΤΡ molded product that does not contain, ΡΤ

Ρ the humidity was evaluated by reaching humidity after 24 hours of 50%. Furthermore, environmental pyrophosphoric one package Sonai was evaluated containing the data row guard type thermo-hygrometer. The results are shown in Table 1. Evaluation method of the hygroscopic,

○: less than reaching humidity of 10%.

△: less than 40% reach humidity of 10% or more.

X: arrival humidity of 40% or more, or no change.

[0086] [Table 1]

¾ [[008

§3 [

[0089] 1 to the results of Table 3 Table, also the desiccant aluminum pyro a bag without bundled, for PTP blister film capable of maintaining the dried state and a providing child the packaging container It has become possible.

[0090] (Preparation of Master Batch - Part 2)

As a masterbatch 2- 1 (MB2- 1), 50 parts by weight of hydrophobic Zeoraito (trade name: AB

Relative SCENTS3000), LDPE (trade name: PETROTHENE 204, manufactured by one company Tosoh) 50 parts by weight was kneaded to prepare a pelletized granular 榭脂.

[0091] as a masterbatch 2- 2 (MB2- 2), with respect to molecular sieve 3A in 75 parts by weight, LDPE (trade name: Petrocene 204) 25 parts by weight of kneaded to, prepare pellets of granular 榭脂 the did.

[0092] as a masterbatch 2- 3 (MB2- 3), and against the molecular sieve 13X of 50 parts by weight, LDPE (trade name: Petrocene 204) by kneading 50 parts by weight prepare a pelletized granular 榭脂did.

[0093] as a master batch 2-4 (MB2- 4), with respect to the hydrophobic Zeoraito of 10 parts by weight, L DPE: Preparation (trade name Petrocene 204) by kneading 90 parts by weight of pellets of granular 榭脂did.

[0094] (Example 2 1 one 1)

As 榭脂 adsorption layer, using only MB2- 1 in the main adsorbent layer, using a secondary adsorption layer MB2- 4 only, to prepare a two-kind three-layer film by a multilayer inflation method. The film thickness of the two-kind three-layer film is a by-adsorbent layer Z main adsorbent layer Z auxiliary adsorbent layer = 10 m / 50 μ m / 10 μ m.

The corona treatment was performed in order to improve the [0095] One of polypropylene 10 mu m side of the adhesion of the two-kind three-layer film obtained. The 10 m of thickness in the sub-adsorbed layer side was released Ri by the baked follow thermal shrinkage history 250 μ m ΡΤΡ polypropylene film (trade name: CPPE0025NA, Mitsubishi 榭脂 Co., Ltd.), lamination by a dry lamination method It was obtained Fuinoremu for PTP or blister pack Te.

[0096] (Example 2 1 2)

In Example 2 1 1, in place of the MB2- 1 used in the main adsorption layer, 80 parts by weight of M B 2 - 1 and LLDPE (trade name: Eboriyu SP2020) was changed to a 20 parts by weight, implementation example 2 1-1 in the same manner as to prepare the film for PTP or blister pack.

[0097] (Example 2 1 3~2- 1 6)

In Example 2-1- 2, except for changing as shown in Table 4 the mixing ratio of the MB2-1 and LLDPE of the main adsorbent layer, to prepare a film PTP or blister pack in a similar manner.

[0098] (Comparative Example 2 1 1)

! Example 2 1 - Te Contact /, to 1, except for changing the MB2- 1 of the main adsorption layer MB2- 2, to prepare a film PTP or blister pack in a similar manner.

[0099] (Comparative Example 2 1 2~2- 1 6)

In Comparative Example 2-1- 1, the mixing ratio of the MB2- 2 and LLDPE of the main adsorption layer, except for changing as shown in Table 5, to prepare a film PTP or blister pack in a similar manner.

[0100] (Example 2 2- 1)

In Example 2 1 1, in place of the MB2- 1 used in the main adsorption layer, except for changing to the M B2- 1 and 10 parts by weight MB2- 3 of 90 parts by weight, Example 2 1- 1 in the same manner as to prepare the film for PTP or blister pack.

[0101] (Example 2 2- 2~2- 2-6)

Contact to Example 2 2 1, Te, except for changing as shown in Table 6 the mixing ratio of the MB2- 1 and MB2- 3 main adsorption layer, the PTP or blister pack film in the same manner It was produced.

[0102] The above manufacturing PTP or blister pack film obtained by the method, the blister Roh Tsu perform PTP molded by click molding machine (manufactured by CKD (Ltd.)) to give the PTP or blister pack packaging container. Each PTP or packaging containers for blister packs, to evaluate the formability as follows. The results are shown in Tables 4 to 6.

[0103] Evaluation method of moldability,

○: good regardless of wrinkles or the like at the time of PTP molding

△: the occurrence of wrinkles can be seen in part at the time of PTP molding

X: ΡΤΡ wrinkles occur during molding failure [0104] Moreover, it added dropwise two Toryechiruamin or toluene vial, to one PTP or put blister pack film and sealed. Put 24 hours the vial in a constant temperature bath at 40 ° C. Then smell the odor when opened (functional test), 吸臭 of the 〇: odor is reduced, X: it was evaluated as no change. The results are shown in Tables 4 to 6.

[0105] [Table 4]

[0106] [Table 5]

[0107] [Table 6]

Of the main adsorption layer

吸臭 of

Mixing ratio (parts) formability

MB2-1 MB2 -3 Toryechiruamin toluene Example 2 _ 2 _ 1 90 10 O O O Example 2 _ 2 _ 2 80 20 O O O Example 2 2 3 50 50 0 O O Example 2 2- 4 30 70 〇 o 〇

Example 2 2 5 20 80 0 O O

From the results of Example 2 2 6 10 90 O O O Table 4 Table 6 also an adsorbent aluminum pyro a bag without bundled, PTP or blister pack films and PTP capable of maintaining the 吸臭 effect or it has become possible to provide a blister pack for the packaging container.

Claims

The scope of the claims
[I] and the adsorption layer, a PTP blister film laminated to a Bruno rear more in the outermost layer, the adsorption layer is a physical adsorbent and at least one adsorption selected group force consisting I 匕学 adsorbent film for PTP or blister pack and having a agent.
[2] The adsorbent, based on the weight of the adsorption layer, PTP or film for blister packs according to claim 1, characterized that you containing 5 wt% to 70 wt% or less.
[3] The adsorption layer, based on the weight of the adsorber layer, Fi for PTP or blister pack according to claim 1 or 2, characterized in that it contains following 70 wt% 30 wt% or more pigment components Noremu.
[4] the physical adsorbent, PTP or blister pack film according to any one of claims 1 to 3, characterized in that a synthetic Zeoraito.
[5] the physical adsorbent, PTP or blister pack film according to claims 1 to 4, whichever is one wherein, wherein the hydrophobic Zeoraito.
[6] The chemical adsorbent, PTP or blister pack film according to claims 1 to 5, whichever is one wherein characterized in that it is a Sani匕 calcium.
[7] The adsorbent layer, PTP or blister pack film according to any one of claims 1 to 6, characterized in that it consists of a main adsorbent layer and the sub adsorption layer.
[8] The content of the adsorbent in the main adsorbent layer film for a PTP or blister pack according to claim 7, characterized in that more than the content of the adsorbent in the sub-suction layer
[9] The barrier layer are polypropylene, polyvinyl chloride, any of claims 1 to 8, feature by containing the polytetra full O b ethylene 及 beauty least one compound selected the group force consisting of aluminum force PTP or blister pack fill beam according to an item or.
[10] The film thickness of the PTP or blister pack films, PTP or blister pack for click according to any one of claims 1 to 9, characterized in der Rukoto below 20 mu m or more 500 mu m the film.
[II] film for the PTP or blister pack, PTP according to said barrier layer and the adsorption layer, in any one of claims 1 to 10, characterized by being stacked in de Rye lamination or blister pack for the film.
[12] Film for the PTP or blister pack, PTP according to said barrier layer and the adsorption layer, in any one of claims 1 to 10, characterized by being stacked in pressed out lamination or blister pack for the film.
[13] The PTP or film for blister packs, and the barrier layer and the adsorption layer, as claimed in any one of claims 1 to 10, characterized in that formed by laminating at Sa down Dorami Natick Chillon method PTP or blister pack for the film.
[14] and the adsorption layer, Noria also PTP was bonded to the substrate and laminated film further and to the outermost layer a packaging container for a blister pack,
The adsorption layer is physical adsorption agent and PTP or blister pack packaging container, characterized in that it comprises at least one sorbent selected group force consisting I 匕学 adsorbent.
[15] The adsorbent, based on the weight of the adsorption layer, PTP or blister pack packaging container according to claim 14, characterized that you containing 70 wt% 5 wt% both inclusive.
[16] The adsorption layer, based on the weight of the adsorber layer, packaging PTP or blister pack according to claim 14 or 15, characterized in that it contains following 70 wt% 30 wt% or more pigment components container.
[17] the physical adsorbent, PTP or blister pack packaging container according to claim 14 or 16 Neu deviation or claim characterized in that it is a synthetic Zeoraito.
[18] the physical adsorbent, PTP or blister pack packaging container according to any one of claims 14 to 17, wherein the hydrophobic Zeoraito.
[19] The chemical adsorbent, PTP or blister pack packaging container according to claim 14 or 18 Neu deviation or claim characterized in that it is a Sani匕 calcium.
[20] The adsorption layer, PTP or blister pack packaging container according to any one of claims 14 to 19, characterized in that it consists of a main adsorbent layer and the sub adsorption layer.
[21] The content of the adsorbent in the main adsorbent layer, PTP or blister pack according to any one of claims 14 to 20, characterized in that more than the content of the adsorbent in the sub-suction layer use packaging container.
[22] The barrier layer are polypropylene, polyvinyl chloride, polytetra full O b either ethylene 及 beauty in that it contains at least one compound selected the group force consisting of aluminum force of claims 14 to 21, FEATURES either PTP or packing trough ¾ blister pack according to one wherein :.
[23] The base material, PTP or blister pack packaging container according to any one of claims 14 to 22, characterized in that an aluminum foil.
PCT/JP2006/308712 2005-04-26 2006-04-26 Film for ptp or blister pack, and packaging container for ptp or blister pack WO2006115264A1 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2005128001 2005-04-26
JP2005-128001 2005-04-26
JP2005-159353 2005-05-31
JP2005159353A JP4659523B2 (en) 2005-04-26 2005-05-31 Packaging container for a blister film and blister
JP2006-120585 2006-04-25
JP2006120585A JP5429948B2 (en) 2005-04-26 2006-04-25 Ptp or blister pack for the film and ptp or packaging container for the blister pack

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CN 200680022999 CN101208244B (en) 2005-04-26 2006-04-26 Film for PTP or blister pack, and packaging container for PTP or blister pack

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US8003179B2 (en) 2002-06-20 2011-08-23 Alcan Packaging Flexible France Films having a desiccant material incorporated therein and methods of use and manufacture
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Also Published As

Publication number Publication date Type
KR20080009297A (en) 2008-01-28 application
KR100922490B1 (en) 2009-10-20 grant
CN101208244A (en) 2008-06-25 application
JP2006327690A (en) 2006-12-07 application
CN101208244B (en) 2010-12-08 grant
JP2006334819A (en) 2006-12-14 application
JP4659523B2 (en) 2011-03-30 grant
JP5429948B2 (en) 2014-02-26 grant

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