WO2015147030A1 - 錐体状突起シートの梱包体及びその製造方法 - Google Patents
錐体状突起シートの梱包体及びその製造方法 Download PDFInfo
- Publication number
- WO2015147030A1 WO2015147030A1 PCT/JP2015/059049 JP2015059049W WO2015147030A1 WO 2015147030 A1 WO2015147030 A1 WO 2015147030A1 JP 2015059049 W JP2015059049 W JP 2015059049W WO 2015147030 A1 WO2015147030 A1 WO 2015147030A1
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- WO
- WIPO (PCT)
- Prior art keywords
- sheet
- cone
- shaped projection
- shaped
- forming
- Prior art date
Links
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Classifications
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- B65B9/02—Enclosing successive articles, or quantities of material between opposed webs
- B65B9/04—Enclosing successive articles, or quantities of material between opposed webs one or both webs being formed with pockets for the reception of the articles, or of the quantities of material
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- A61M2207/00—Methods of manufacture, assembly or production
Definitions
- the present invention relates to a packing body for a cone-shaped projection sheet including a plurality of cone-shaped projections and a method for manufacturing the same.
- the resin sheet having a plurality of fine recesses is employed in, for example, a cone-shaped projection molding die for manufacturing a plurality of cone-shaped projections of a cone-shaped projection sheet (see, for example, Patent Document 1). .
- An example of the cone-shaped projection sheet is a patch for transdermal administration.
- a transdermal patch is used as one of means for non-invasively administering a drug or the like from the surface of a living body such as skin or mucous membrane. In that case, the drug is adsorbed to the cone-shaped projections.
- the plurality of cone-shaped projections of the cone-shaped projection sheet have a fine shape, they are relatively easily damaged. And the completed cone-shaped projection sheet
- the user When using the cone-shaped projection sheet, the user removes the lid of the blister pack, for example, and then removes the transdermal patch from the blister pack and finally applies it to his skin.
- the patch for transdermal administration is directly taken out from the blister pack, there is a possibility that a plurality of cone-shaped projections may be damaged if the removal operation is difficult.
- An object of the present invention is to protect a plurality of cone-shaped projections of a cone-shaped projection sheet.
- An object of the present invention is to make it difficult to break a plurality of cone-shaped projections when a cone-shaped projection sheet is taken out from a package and used.
- a packing body for a cone-shaped projection sheet includes a cone-shaped projection sheet, a cone-shaped projection forming sheet, and a seal sheet.
- the cone-shaped projection sheet has a base and a plurality of cone-shaped projections formed on the surface of the base.
- the cone-shaped projection forming sheet has a plurality of cone-shaped recesses used to form a plurality of cone-shaped projections and in which a plurality of cone-shaped projections are arranged, and is in close contact with the surface of the substrate. In this state, the plurality of cone-shaped projections are protected.
- the seal sheet seals the cone-shaped projection sheet between the cone-shaped projection sheet and the cone-shaped projection sheet by being fixed to the cone-shaped projection molding sheet in the package of the cone-shaped projection sheet.
- the plurality of cone-shaped projections of the cone-shaped projection sheet are formed by the plurality of cone-shaped concave portions of the cone-shaped projection forming sheet, and the state protected by the plurality of cone-shaped concave portions is maintained thereafter. Is done. That is, the cone-shaped projections of the cone-shaped projection sheet are reliably protected.
- the cone-shaped projection sheet is sealed between the cone-shaped projection forming sheet and the seal sheet, the quality of the cone-shaped projection sheet is maintained for a long time.
- the cone-shaped projection forming sheet is used as a member constituting the package together with the seal sheet, the cone-shaped projection sheet of the cone-shaped projection sheet is protected while reliably protecting the plurality of cone-shaped projections.
- the number of parts of the package can be reduced.
- the conical-projections forming sheet has a concave storage portion in which a plurality of conical recesses are formed, and the conical-projections sheet may be disposed in the concave storage portion.
- the packing body of the cone-shaped projection sheet is fixed to the second surface of the base of the cone-shaped projection sheet and further adhered to the cone-shaped projection molding sheet, so that a plurality of cones of the cone-shaped projection sheet is obtained.
- a support that maintains the state in which the protrusions are arranged in the plurality of conical recesses of the conical protrusion forming sheet.
- the support is adhered to the cone-shaped projection molding sheet, so that the plurality of cone-shaped projections of the cone-shaped projection sheet are arranged in the plurality of cone-shaped recesses of the cone-shaped projection molding sheet.
- the maintained state is maintained. Furthermore, when the support is peeled from the cone-shaped projection forming sheet, the cone-shaped projection sheet can be separated from the cone-shaped projection forming sheet together with the support.
- a portion of the conical-projections forming sheet to which the support is adhered may be subjected to a treatment for reducing the peel strength.
- the treatment for reducing the peel strength is applied to the portion of the cone-shaped projection forming sheet to which the support is adhered, the strength for adhering the support to the human body or other members is reduced. It becomes easy to peel a support body from the sheet
- the treatment for reducing the peel strength may be one or both of applying a release agent and using a material having a release effect.
- the peel strength between the support and the seal sheet may be 2.0 to 6.5 (N / 10 mm).
- the peel strength between the support and the cone-shaped projection forming sheet may be 0.5 to 4.0 (N / 10 mm).
- the plurality of cone-shaped projections of the cone-shaped projection sheet are formed by the plurality of cone-shaped recesses of the cone-shaped projection forming sheet, and are protected by the plurality of cone-shaped recesses thereafter. That is, the plurality of cone-shaped projections of the cone-shaped projection sheet are reliably protected.
- the manufacturing method may further include a step of forming a concave storage portion at a location where the plurality of cone-shaped recesses are formed on the cone-shaped projection forming sheet before forming the plurality of cone-shaped recesses. . In that case, in the step of forming the cone-shaped projection sheet, the cone-shaped projection sheet is formed in the concave storage portion.
- a plurality of cone-shaped projections of the cone-shaped projection sheet are formed into cone-shaped projections.
- the support is adhered to the cone-shaped projection molding sheet, so that the plurality of cone-shaped projections of the cone-shaped projection sheet are arranged in the plurality of cone-shaped recesses of the cone-shaped projection molding sheet.
- the maintained state is maintained.
- the support is peeled from the cone-shaped projection forming sheet, the cone-shaped projection sheet is separated from the cone-shaped projection forming sheet together with the support.
- seat may further be provided with the following step. ⁇ before the step of forming the cone-shaped projection sheet, a step of applying a treatment for reducing the peel strength to the portion of the cone-shaped projection molding sheet to which the support is adhered.
- a treatment for reducing the peel strength to the portion of the cone-shaped projection molding sheet to which the support is adhered.
- the support is conical without reducing the strength of adhering the support to the human body or other members. It becomes easy to peel off from the cone-shaped projection molding sheet together with the cylindrical projection sheet.
- the cone-shaped projection sheet is taken out from the cone-shaped projection molding sheet and used, the plurality of cone-shaped projections are not easily damaged.
- the order of the steps is not limited unless specifically described. Moreover, each step may be performed simultaneously or partially overlapping.
- the treatment for reducing the peel strength may be one or both of applying a release agent and using a material having a release effect.
- conical projection sheet packing body and the manufacturing method thereof according to the present invention a plurality of conical projections of the conical projection sheet can be protected.
- FIG. 5 is a schematic diagram illustrating operations of cleaning, drying, and preheating. The schematic diagram explaining the operation
- molding before a cone-shaped recessed part is formed.
- molding after the cone-shaped recessed part was formed.
- molding after the cone-shaped recessed part was formed.
- the schematic diagram for demonstrating the process of drying cone-shaped projection material The schematic diagram for demonstrating the process of temporarily fixing a sealing sheet to the sheet
- seat Sectional drawing of the package of the microneedle sheet
- Sectional drawing which shows the state which peeled off the cone-shaped projection sheet
- the schematic diagram which shows the process of apply
- the schematic diagram which shows the process of apply
- the schematic diagram which shows the process of apply
- molding after the cone-shaped recessed part was formed.
- step difference surface The schematic diagram which shows the process of embossing on a level
- FIG. 2 is a schematic cross-sectional view of a microneedle molding sheet filled with a microneedle material.
- seat Typical sectional drawing for demonstrating the process which manufactures a package from the shaping
- seat Typical sectional drawing for demonstrating the process which manufactures a package from the shaping
- seat The top view of the shaping
- seat The top view of the shaping
- seat The top view of the shaping
- seat Typical sectional drawing for demonstrating the process which manufactures a package from the shaping
- seat The top view of the shaping
- FIG. 1 is a partial plan view of a packing body of cone-shaped projection sheets as a first embodiment of the present invention.
- 2 is a cross-sectional view taken along the line II-II in FIG.
- the cone-shaped projection sheet packaging body 1 is composed of a plurality of cone-shaped projection sheets 3 with a support and a packing material 5 for packaging the cone-shaped projection sheets 3 with a support.
- a plurality of cone-shaped projection sheets 3 with a support are housed in the package 1 of cone-shaped projection sheets, but the number of cone-shaped projection sheets 3 with a support is single. May be.
- the cone-shaped projection sheet 3 with a support is a member that is packed with a packing material 5 and is taken out and used as necessary.
- the cone-shaped projection sheet 3 with a support is a sheet-shaped article, and mainly includes a support 21 and a cone-shaped projection sheet 23.
- the cone-shaped projection sheet 23 is a sheet-shaped article in which a plurality of cone-shaped projections described later are formed on one surface.
- the cone-shaped projection sheet 23 has a thickness of about several hundred ⁇ m.
- the planar shape of the cone-shaped projection sheet 23 is a slanted ball shape that is smoothly curved as a whole and has a wide portion and a narrow portion.
- the shape of the cone-shaped projection sheet 23 may be a circle, an ellipse, a triangle, a quadrangle, a square, or other shapes.
- a quadrangular projection sheet 23 for example, in the case of a quadrangle, the side is several mm to several tens mm.
- the cone-shaped projection sheet 23 includes a sheet-like base body 23a and a plurality of cone-shaped projections 23b.
- the plurality of conical protrusions 23b are formed on the surface 23c (the lower surface in this embodiment) of the base body 23a.
- the cone-shaped projection sheet 23 is a patch for transdermal administration that is used to administer a drug or the like, for example, by being stuck so as to come into contact with human skin. Specifically, administration of a drug or the like is promoted by the substrate 23a being stuck to the skin and the cone-shaped protrusion 23b being stuck into the skin.
- the cone-shaped projection sheet 23 is mainly composed of a water-soluble drug or a material obtained by adding a drug to a water-soluble polymer such as hyaluronic acid, water-soluble collagen, dextran, and chondroitin sulfate.
- a water-soluble polymer such as hyaluronic acid, water-soluble collagen, dextran, and chondroitin sulfate.
- the water-soluble polymer to which the drug is added is preferably a water-soluble polymer that is soluble in the living body. Can be mentioned.
- Water-soluble polymers include sodium chondroitin sulfate, hyaluronic acid, collagen (or hydrolyzed collagen), gelatin, glycogen, dextran, dextrin, dextran sulfate, cyclodextrin, chitosan, proteoglycan, pullulan, hydroxypropylcellulose, alginic acid, agarose , Glycogen, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, and at least one substance selected from the group consisting of polyvinylpyrrolidone, polypinyl alcohol, and carboxyvinyl polymer. About these water-soluble polymers, only one may be used and you may use in combination of multiple types.
- the support 21 is a sheet for supporting the cone-shaped projection sheet 23, and is made of, for example, a resin.
- the support 21 is fixed to the second surface 23 d of the base body 23 a of the cone-shaped projection sheet 23 and is further adhered to the cone-shaped projection molding sheet 7.
- the support 21 mainly has a first sheet 25 and a second sheet 27.
- the first sheet 25 is arranged on the upper side of the second sheet 27 in the figure, and has a larger area than the second sheet 27.
- the second sheet 27 is fixed to the lower surface of the first sheet 25 by the first adhesive layer 26.
- a first adhesive layer 28 is provided on the lower surface of the second sheet 27.
- the support 21 is fixed to the second surface 23 d of the cone-shaped projection sheet 23 by the first adhesive layer 28.
- the first adhesive layer 26 is also provided on the outer surface of the first sheet 25 on the outer peripheral side of the second sheet 27. Therefore, the support 21 (that is, the cone-shaped projection sheet 3 with the support) is fixed to the cone-shaped projection forming sheet 7 by the first adhesive layer 26.
- the packing material 5 is a member for packing the cone-shaped projection sheet 3 with a support.
- the packing material 5 includes a conical-projections forming sheet 7 and a seal sheet 9, and the support-supported conical-projections sheet 3 is packed by attaching both sheets together.
- the cone-shaped projection forming sheet 7 is a sheet-like member and has a plurality of storage portions 31 for storing the cone-shaped projection sheet 3 with a support.
- the storage portion 31 has a convex shape that expands toward the outside of the packaging material 5, and a concave storage portion 31 a is formed inside the packaging material 5.
- the planar shape of the concave storage portion 31a is the same as the planar shape of the cone-shaped projection sheet 3 with the support.
- the concave storage portion 31 a is composed of a bottom surface 33 and an annular step surface 35 that is around the bottom surface 33 and is higher than the bottom surface 33.
- a flat surface 37 is provided around the concave storage portion 31a (that is, around the step surface 35).
- the concave concave storage portion 31 a of the storage portion 31 is stepped by the bottom surface 33, the annular step surface 35, and the flat surface 37.
- the outer peripheral portion of the support 21 is adhered to the annular step surface 35 via the first adhesive layer 26.
- a release agent may be applied to the stepped surface 35 so that the outer peripheral portion of the support 21 is easily peeled off.
- the conical-projections forming sheet 7 has a one-layer structure made of a polyolefin-based resin such as polyethylene or polypropylene in consideration of being used as a member for forming a plurality of conical recesses 33a (described later). .
- the conical-projections forming sheet 7 may be composed of a plurality of layers.
- the cone-shaped recessed part 33a is a dent opened upward, and does not penetrate the cone-shaped projection forming sheet 7.
- the cone-shaped projection sheet 3 with a support is stored.
- the cone-shaped projection sheet 23 is formed in close contact with the bottom surface 33, and the bottom surface 33 is in close contact with the surface 23 c of the base body 23 a of the cone-shaped projection sheet 23.
- the cone-shaped protrusion 23b is disposed in the cone-shaped recess 33a.
- the bottom surface 33 functions as a formation surface and a protection surface of the conical protrusions 23b.
- the support 21 is adhered to the cone-shaped projection molding sheet 7, so that the plurality of cone-shaped projections 23 b of the cone-shaped projection sheet 23 are formed on the cone-shaped projection molding sheet 7.
- positioned at the several cone-shaped recessed part 33a is maintained.
- the outer peripheral portion of the support 21 (the portion fixed by the first adhesive layer 26) is formed into a cone-shaped projection when the cone-shaped projection sheet 3 with the support is taken out from the cone-shaped projection molding sheet 7. It can be easily peeled off from the sheet 7 for use.
- the 1st adhesion layer 26 functions as an adhesion part after taking out the cone-shaped projection sheet
- the seal sheet 9 is affixed to the inner surface of the cone-shaped projection forming sheet 7, and is a sheet-like member for sealing the support-provided cone-shaped projection sheet 3 in the concave storage portion 31a between them. It is. Specifically, the seal sheet 9 has a surface resin layer 41 and a metal layer 43. The surface resin layer 41 can be printed and further has a function of protecting the metal layer 43. The metal layer 43 is provided on the lower surface of the surface resin layer 41. The metal layer 43 is made of aluminum or an alloy thereof and has high moisture resistance.
- a second adhesive layer 42 and a second adhesive layer 44 are provided on the surface of the metal layer 43 opposite to the surface resin layer 41.
- the second adhesive layer 42 is for adhering the support 21 to the seal sheet 9.
- the second adhesive layer 44 is for bonding the seal sheet 9 to the cone-shaped projection forming sheet 7, and specifically, bonded to the flat surface 37 of the cone-shaped projection forming sheet 7. .
- the seal sheet 9 is bonded to the inner surface of the cone-shaped projection forming sheet 7 in a state of covering the cone-shaped projection sheet 23, and the concave storage portion 31a is sealed by both.
- the cone-shaped projections 23b of the cone-shaped projection sheet 23 are formed by a plurality of cone-shaped concave portions 33a of the cone-shaped projection forming sheet 7 (described later). ) And thereafter, it is protected by the cone-shaped projection forming sheet 7.
- FIG. 3 is a cross-sectional view showing a state where the seal sheet is peeled off from the conical-projections forming sheet.
- the cone-shaped projection sheet 3 with the support is separated from the cone-shaped projection forming sheet 7 together with the seal sheet 9.
- the support-attached cone-shaped projection sheet 3 is taken out from the concave storage portion 31a of the cone-shaped projection forming sheet 7.
- the user peels off the cone-shaped projection sheet 3 with the support from the seal sheet 9.
- the support-attached cone-shaped projection sheet 3 is attached to human skin.
- the support body 21 is stuck to the skin by the first adhesive layer 26, and the cone-shaped projections 23b of the cone-shaped projection sheet 23 come into contact with the skin.
- FIG. 5 is a cross-sectional view of the blank of the conical-projections forming sheet.
- a plurality of storage portions 31 are formed in the cone-shaped projection forming sheet 7 in advance.
- the storage portion 31 is formed by vacuum forming, vacuum / pressure forming, or cold forming.
- a flat sheet is pushed in from the upper part of the tool die using one or more punch tools, and the concave shape is formed by a concave tool die corresponding to a punch-shaped concave portion.
- FIG. 6 is a schematic diagram for explaining the operations of cleaning, drying, and preheating.
- a general room 38 and a clean room 39 are provided continuously.
- the general chamber 38 is provided with a fluid chamber 45 and a rinse chamber 47.
- the clean room 39 is provided with a drying room 49.
- An air blow chamber 51 is provided at the boundary between the general room 38 and the clean room 39.
- FIG. 7 is a schematic diagram for explaining the operation of forming the conical recess.
- a molding device 53 and a cooling zone 55 are provided continuously.
- the molding device 53 is a device for forming a plurality of fine cone-shaped concave portions 33 a on the bottom surface 33 of the cone-shaped projection molding sheet 7.
- the molding device 53 includes a high-precision press machine 57 and a needle-shaped press die 59.
- the press die 59 has a plurality of press portions 61.
- the press portion 61 has a shape that matches the bottom surface 33 of the concave storage portion 31a, and has a plurality of processing projections 61a on the lower surface.
- FIG. 8A is a schematic view of a cone-shaped projection forming sheet before the cone-shaped recess is formed.
- FIG. 8B is a partial cross-sectional view of the cone-shaped projection forming sheet before the cone-shaped recess is formed.
- the press part 61 contacts the bottom surface 33
- the cone-shaped projection molding sheet 7 is softened by preheating before molding.
- FIG. 9 a plurality of conical recesses 33a are formed on the bottom surface 33 by the processing projections 61a.
- FIG. 9 is a cross-sectional view for explaining a step of forming a conical recess in the conical-projection forming sheet.
- the press machine is controlled by a machine that can control the press location, pressing pressure, pressing time, etc. with high accuracy.
- FIG. 10A is a schematic view of a cone-shaped projection forming sheet after the cone-shaped recess is formed.
- FIG. 10B is a partial cross-sectional view of the cone-shaped projection forming sheet after the cone-shaped recess is formed.
- the conical recess 33a has, for example, a conical shape or a pyramid shape, and is open toward the upper side of the drawing.
- FIG. 11 is a schematic diagram for explaining a process of dropping a cone-shaped projection material onto a cone-shaped projection forming sheet.
- a dispenser 63 is provided.
- the dispenser 63 is a device that drops and fills the conical projection material into the concave storage portion 31 a of the storage portion 31.
- the cone-shaped projection material 56 is, for example, sodium hyaluronate dissolved in a solvent made of water or the like.
- As the solvent a medium in which water-soluble polymer is soluble in addition to water is selected.
- FIG. 12 is a partial cross-sectional view of a cone-shaped projection forming sheet filled with a cone-shaped projection material.
- FIG. 13 is a schematic diagram for explaining a process of drying the cone-shaped projection material.
- an IR drying furnace 65 and a buffer 67 are provided.
- the cone-shaped projection material 23A is heated and dried together with the cone-shaped projection forming sheet 7.
- moisture and the solvent material are evaporated from the conical projection material 23A.
- the cone-shaped projection material 23A contracts by drying from the state of FIG. 12, and the volume is reduced to the position of the dashed line.
- the cone-shaped projection sheet 23 having the base body 23a and the plurality of cone-shaped projections 23b is formed.
- FIG. 14 is a schematic diagram for explaining a process of temporarily fixing the seal sheet to the cone-shaped projection forming sheet.
- a seal sheet temporary fixing device 69 is provided.
- the seal sheet temporary fixing device 69 is a device for temporarily fixing the seal sheet 9 to the cone-shaped projection forming sheet 7.
- the seal sheet temporary fixing device 69 uses a sheet material 70.
- the sheet material 70 includes a base sheet 71, a seal sheet 9 provided on the base sheet 71, and a separator sheet 73 attached to the surface of the seal sheet 9.
- the seal sheet temporary fixing device 69 temporarily fixes the seal sheet 9 to the cone-shaped projection forming sheet 7 while peeling the separator sheet 73 from the seal sheet 9, while collecting the base sheet 71.
- FIGS. 15 and 16 a plurality of supports 21 are mounted in advance on the above-described seal sheet 9 at predetermined positions. That is, the support 21 is attached to the cone-shaped projection forming sheet 7 at the same time when the seal sheet is temporarily fixed to the cone-shaped projection forming sheet 7.
- the seal sheet 9 is provided with a second adhesive layer 44 which is fixed to the flat surface 37 of the cone-shaped projection forming sheet 7.
- FIG. 15 is a cross-sectional view of the sealing sheet and the conical-projections forming sheet.
- FIG. 16 is a cross-sectional view of a state in which the seal sheet is temporarily fixed to the cone-shaped projection forming sheet.
- FIG. 17 is a schematic diagram for explaining the process of fixing the seal sheet to the conical-projections forming sheet and the process of cutting the completed conical-projections-sheet packaging.
- a sealer device 77 and a cutting device 79 are provided continuously.
- the sealer device 77 includes a deaeration sealer device 81 and a main heat pressure device 83.
- the deaeration sealer device 81 deaerates the air in the gap.
- the hot-pressing device 83 heats, adheres the second sheet 27 of the support 21 to the cone-shaped projection sheet 23 by the first adhesive layer 28, and further the first adhesive layer 26 to the first of the support 21.
- the sheet 25 is fixed to the step surface 35.
- seat is obtained.
- the conical projection sheet package 1 is cut into one unit by the cutting device 79.
- the cone-shaped projection sheet 23 is brought into close contact with the cone-shaped projection molding sheet 7 by the first adhesive layer 26 of the support 21. Is maintained. Therefore, the cone-shaped projections 23b are protected when the package 1 of the cone-shaped projection sheet is conveyed or used. Specifically, the state in which the cone-shaped projections 23b are housed in the cone-shaped recesses 33a is maintained by the adhesive force of the first adhesive layer 26 of the support 21, and as a result, the cone-shaped projections 23b are protected. ing.
- the conical-projections forming sheet 7 functions as a packaging material with respect to the conical-projections sheet 23, but further has the following two functions.
- the conical-projections forming sheet 7 functions as a forming die for forming the conical-projections 23 b of the conical-projections sheet 23.
- the cone-shaped projection forming sheet 7 functions as a protective material for protecting the cone-shaped projection 23 b of the cone-shaped projection sheet 23.
- the cone-shaped projection forming sheet 7 has a plurality of functions with respect to the cone-shaped projection sheet 23, it is not necessary to use a special member for protecting the cone-shaped projection 23b. Has become easier. Furthermore, after manufacturing the cone-shaped projection sheet, the operation of removing the cone-shaped projection sheet from the mold or packaging with another packaging member is not required.
- Conical Projection Sheet Packing Body 1 (an example of a conical projection sheet packaging) is a conical projection sheet 23 (cone An example of a body-like projection sheet), a cone-like projection molding sheet 7 (an example of a cone-like projection molding sheet), and a seal sheet 9 (an example of a seal sheet).
- the cone-shaped projection sheet 23 includes a base body 23a (an example of a base body) and a plurality of cone-shaped projections 23b (an example of a plurality of cone-shaped protrusions) formed on the surface 23c.
- the cone-shaped projection molding sheet 7 includes a plurality of cone-shaped recesses 33a (an example of a cone-shaped recess) in which the cone-shaped projections 23b are arranged and used to form the plurality of cone-shaped projections 23b.
- the cone-shaped projection sheet 23 is protected in a state of being in close contact with the surface 23 c of the cone-shaped projection sheet 23.
- the seal sheet 9 is fixed to the cone-shaped projection forming sheet 7 to seal the cone-shaped projection sheet 23 between the cone-shaped projection forming sheet 7.
- the plurality of cone-shaped projections 23 b of the cone-shaped projection sheet 23 are formed by the plurality of cone-shaped recesses 33 a of the cone-shaped projection molding sheet 7, and thereafter the cone-shaped projection molding sheet 7. Maintaining a protected state. Therefore, the plurality of cone-shaped projections 23b of the cone-shaped projection sheet 23 are reliably protected. Moreover, since the cone-shaped projection sheet 23 is sealed between the cone-shaped projection molding sheet 7 and the seal sheet 9, the quality of the cone-shaped projection sheet 23 is maintained long. As described above, since the cone-shaped projection forming sheet 7 is used as a member constituting the package together with the seal sheet 9, the cone-shaped projections 23b are reliably protected while being conical. The number of parts of the package 1 of the protruding sheet can be reduced.
- the method for manufacturing the conical projection sheet package 1 includes the following steps. Step of forming a plurality of conical recesses 33a on the conical-projections forming sheet 7 (see FIGS. 7 to 10B) A plurality of cone-shaped projections 23b formed on the base 23a and its surface 23c and disposed in the plurality of cone-shaped recesses 33a by supplying the cone-shaped projection material to the cone-shaped projection molding sheet 7. A step of forming a cone-shaped projection sheet 23 having the following (see FIGS. 11 to 12) Step of sealing the cone-shaped projection sheet 23 between the cone-shaped projection molding sheet 7 and the seal sheet 9 by fixing the seal sheet 9 to the cone-shaped projection molding sheet 7
- the cone-shaped projection sheet 23 is formed in the concave storage portion 31a of the cone-shaped projection molding sheet 7, and the state is maintained. Specifically, the plurality of cone-shaped projections 23b of the cone-shaped projection sheet 23 are formed by the plurality of cone-shaped concave portions 33a of the cone-shaped projection molding sheet 7, and thereafter the cone-shaped projection molding sheet 7 is also formed. Is kept protected by. Therefore, the plurality of cone-shaped projections 23b of the cone-shaped projection sheet 23 are reliably protected. Moreover, since the cone-shaped projection sheet 23 is sealed between the cone-shaped projection molding sheet 7 and the seal sheet 9, the quality of the cone-shaped projection sheet 23 is maintained long.
- the cone-shaped projection forming sheet 7 is used as a member constituting the package together with the seal sheet 9, the cone-shaped projections 23b are reliably protected while being conical. The number of parts of the package 1 of the protruding sheet can be reduced.
- the present invention is not limited to the above embodiment, and various modifications can be made without departing from the scope of the invention.
- a plurality of embodiments and modifications described in this specification can be arbitrarily combined as necessary.
- the support when the support is mounted on the cone-shaped projection forming sheet, the support is fixed to the seal sheet in advance, and is mounted on the cone-shaped projection forming sheet together with the seal sheet.
- the support is prepared separately from the seal sheet and may be attached to the cone-shaped projection forming sheet one by one.
- the support is composed of two sheets (the first sheet 25 and the second sheet 27), but the support may be composed of a single sheet.
- the support 21 covers the entire surface of the cone-shaped projection sheet 23 and further has an adhesive layer over the entire outer peripheral side.
- the shape of the support and the positional relationship with the cone-shaped projection sheet The shape of the adhesive layer can be changed as appropriate.
- the cone-shaped sheet with the support is peeled off from the sheet for forming the cone-shaped projection together with the seal sheet, but the cone-shaped sheet with the support is cone-shaped after the seal sheet is peeled off. It may be peeled off from the projection forming sheet.
- the place where the plurality of cone-shaped concave portions 33a are formed in the cone-shaped projection forming sheet 7 is the bottom surface 33 of the concave storage portion 31a, but the plurality of cone-shaped concave portions are other than the concave portions. It may be formed in this part.
- the cone-shaped projection molding sheet may be a flat member, and a plurality of cone-shaped recesses may be formed on the surface thereof.
- the support 21 is fixed to the cone-shaped projection forming sheet 7 by the first adhesive layer 26, so that the cone-shaped projection sheet 23 is brought into close contact with the bottom surface 33, thereby forming a cone shape.
- the state in which the projection 23b is protected by the cone-shaped concave portion 33a is maintained, but the cone-shaped projection sheet may be adhered to the bottom surface by other means, or both may be adhered to each other without taking special measures. Also good.
- Second Embodiment Hereinafter, a second embodiment will be described.
- the second embodiment has the same basic configuration and manufacturing method as the first embodiment. Therefore, the following description will focus on the differences.
- (1) Packing body of cone-shaped projection sheet The packing body 1 of the cone-shaped projection sheet is substantially the same as that of the first embodiment.
- the first adhesive layer 26 is made of, for example, an acrylic component.
- the packing material 5 is generally the same as in the first embodiment.
- a release agent 95 is applied to the stepped surface 35 so that the outer peripheral portion of the support 21 is easily peeled off.
- the release agent 95 is made of silicone, for example.
- the release agent 95 is preferably made of a material that does not harm the human body.
- the release agent 95 is connected to the cylindrical surface (the surface connected to the bottom surface 33) on the inner peripheral side of the step surface 35 and the cylindrical surface (the flat surface 37) on the outer peripheral side of the step surface 35. Surface).
- the release agent 95 is not applied to the bottom surface 33 for the purpose of avoiding contact with the cone-shaped projection sheet 23.
- the cone-shaped projection sheet 3 with a support is stored.
- the cone-shaped projection sheet 23 is formed in close contact with the bottom surface 33, and the bottom surface 33 is in close contact with the surface 23 c of the base body 23 a of the cone-shaped projection sheet 23.
- the cone-shaped protrusion 23b is disposed in the cone-shaped recess 33a.
- the bottom surface 33 functions as a formation surface and a protection surface of the conical protrusions 23b.
- the support 21 is adhered to the cone-shaped projection molding sheet 7, so that the plurality of cone-shaped projections 23 b of the cone-shaped projection sheet 23 are formed on the cone-shaped projection molding sheet 7.
- positioned at the several cone-shaped recessed part 33a is maintained.
- the outer peripheral portion of the support 21 (the portion fixed by the first adhesive layer 26) is formed into a cone-shaped projection when the cone-shaped projection sheet 3 with the support is taken out from the cone-shaped projection molding sheet 7. It can be easily peeled off from the sheet 7 for use.
- the 1st adhesion layer 26 functions as an adhesion part after taking out the cone-shaped projection sheet
- the peel strength between the support 21 and the cone-shaped projection forming sheet 7 is 0.5 to 4.0 (N / 10 mm), preferably 0.5 to 2.0 (N / mm). 10 mm).
- the seal sheet 9 is affixed to the inner surface of the cone-shaped projection forming sheet 7, and is a sheet-like member for sealing the support-provided cone-shaped projection sheet 3 in the concave storage portion 31a between them. It is. Specifically, the seal sheet 9 has a surface resin layer 41 and a metal layer 43. The surface resin layer 41 can be printed and further has a function of protecting the metal layer 43. The metal layer 43 is provided on the lower surface of the surface resin layer 41. The metal layer 43 is made of aluminum or an alloy thereof and has high moisture resistance.
- a second adhesive layer 42 and a second adhesive layer 44 are provided on the surface of the metal layer 43 opposite to the surface resin layer 41.
- the second adhesive layer 42 is for adhering the support 21 to the seal sheet 9.
- the second adhesive layer 42 is made of, for example, an acrylic component.
- the second adhesive layer 44 is for bonding the seal sheet 9 to the cone-shaped projection forming sheet 7, and specifically, bonded to the flat surface 37 of the cone-shaped projection forming sheet 7. .
- the peel strength between the seal sheet 9 and the support 21 is maintained when the seal sheet 9 is peeled off from the cone-shaped projection forming sheet 7, but is easily maintained when the support 21 is peeled off from the seal sheet 9. It must be peelable.
- the peel strength between the seal sheet 9 and the support 21 is 2.0 to 6.5 (N / 10 mm), and preferably 3.0 to 5.0 (N / mm). In this way, the seal sheet 9 is bonded to the inner surface of the cone-shaped projection forming sheet 7 in a state of covering the cone-shaped projection sheet 23, and the concave storage portion 31a is sealed by both.
- FIG. 19 is a cross-sectional view showing a state where the seal sheet is peeled off from the conical-projections forming sheet.
- the cone-shaped projection sheet 3 with the support is separated from the cone-shaped projection molding sheet 7 together with the seal sheet 9.
- the support-attached cone-shaped projection sheet 3 is taken out from the concave storage portion 31a of the cone-shaped projection forming sheet 7.
- FIG. 20 is a cross-sectional view showing a state where the cone-shaped projection sheet with a support is peeled from the seal sheet.
- the user can use the cone-shaped projection sheet 3 with the support according to the purpose.
- the support-attached cone-shaped projection sheet 3 is attached to human skin.
- FIGS. 9B, 10, 11B, 13, 16, and 17 are attached as drawings corresponding to the present embodiment.
- a blank constituting the cone-shaped projection forming sheet 7 is prepared.
- FIG. 21 is a cross-sectional view of a blank of a conical-projections forming sheet.
- a plurality of storage portions 31 are formed in the cone-shaped projection forming sheet 7 in advance.
- the storage portion 31 is formed by vacuum forming, vacuum / pressure forming, or cold forming.
- a flat sheet is pushed in from the upper part of the tool die using one or more punch tools, and the concave shape is formed by a concave tool die corresponding to a punch-shaped concave portion.
- a release agent 95 is applied to the step surface 35.
- a method for applying the release agent 95 will be described with reference to FIGS. 22A to 22C.
- 22A to 22C are schematic views showing a process of applying a release agent to the step surface.
- a tank 201 in which a liquid release agent 95 is stored is prepared.
- a liquid supply member 203 having a shape corresponding to the step surface 35 is provided on the lower surface of the tank 201.
- the liquid supply member 203 is a felt agent, for example, and is a member that allows the release agent 95 to ooze out from the lower portion of the tank 201. Accordingly, as shown in FIG.
- FIG. 23 is a partial cross-sectional view of the cone-shaped projection forming sheet before the cone-shaped recess is formed.
- the press part 61 contacts the bottom surface 33
- the cone-shaped projection molding sheet 7 is softened by preheating before molding.
- a plurality of conical recesses 33a are formed on the bottom surface 33 by the processing projections 61a.
- FIG. 24 is a cross-sectional view for explaining a process of forming a conical recess in the conical-projections forming sheet.
- the press machine is controlled by a machine that can control the press location, pressing pressure, pressing time, etc. with high accuracy.
- FIG. 25 is a partial cross-sectional view of the cone-shaped projection forming sheet after the cone-shaped recess is formed.
- the conical recess 33a has, for example, a conical shape or a pyramid shape, and is open toward the upper side of the drawing.
- the bottom surface 33 is covered with the cone-shaped projection material 23A.
- FIG. 26 is a partial cross-sectional view of a cone-shaped projection forming sheet filled with a cone-shaped projection material.
- a plurality of supports 21 are mounted in advance on the aforementioned seal sheet 9 at predetermined positions.
- FIG. 27 is a cross-sectional view of the seal sheet and the cone-shaped projection forming sheet.
- FIG. 28 is a cross-sectional view of a state in which the seal sheet is temporarily fixed to the conical-projections forming sheet.
- the support 21 is inserted into the concave storage portion 31 a, and as a result, comes close to the cone-shaped projection sheet 23.
- a gap is secured between the second sheet 27 of the support 21 and the cone-shaped projection sheet 23, and further, the first sheet 25 of the support 21 A gap is secured between the step surface 35.
- the release agent is also applied to the step surface 35 and the cylindrical surfaces on both sides in the radial direction. However, the release agent is formed only on the portion where the support 21 is adhered. It only has to be done.
- FIG. 29 is a cross-sectional view of a conical-projection-sheet packaging body according to the third embodiment.
- the release agent 97 is applied only to the step surface 35. Note that the release agent does not need to be applied to the entire stepped surface 35, and may be applied only to the portion to which the support 21 is adhered.
- FIG. 30 is a cross-sectional view of a packing body for a cone-shaped projection sheet in the fourth embodiment.
- no release agent is applied to the stepped surface 35, and instead, a material for improving the release property is employed for the cone-shaped projection forming sheet 7.
- stepped surface 35 can be embossed to reduce the contact area of the pressure-sensitive adhesive and increase the mold release effect.
- FIGS. 31A to 31C are schematic views showing a process of embossing the step surface. As shown in FIGS.
- a molding die 205 having a convex portion 205a with respect to the concave storage portion 31a and an embossed portion 205b corresponding to the stepped surface 35 is used as the molding die 205.
- the molding die 205 is pressed against the tray resin material 207 as shown in FIG. 31B, the concave storage portion 31a and the step surface 35 are formed. Further, the stepped surface 35 is embossed. As a result, an embossed surface 35a is formed on the step surface 35 as shown in FIG. 31C. It is also possible to apply a release agent after using a material having a release effect. In that case, the mold release effect is further increased.
- the cone-shaped projection sheet 23 is formed using the cone-shaped projection molding sheet 7 as a mold, but the cone-shaped projection sheet 23 is manufactured by another apparatus before the cone. It may be arranged in the concave storage portion 31 a of the sheet-like projection forming sheet 7.
- FIGS. 32 and 33 the fifth embodiment will be described with reference to FIGS. 32 and 33.
- FIG. 32 is a cross-sectional view of a packing body for a cone-shaped projection sheet in the fifth embodiment.
- FIG. 33 is a schematic view for explaining a step of temporarily fixing the seal sheet to the cone-shaped projection forming sheet in the fifth embodiment.
- the bottom surface 33 of the cone-shaped projection forming sheet 7 is a flat surface, and a space 10 is secured between the plurality of cone-shaped projections 23 b of the cone-shaped projection sheet 23. That is, the cone-shaped projection sheet 23 is maintained at a position away from the bottom surface 33 while being supported by the support 21. In this way, it is difficult for the cone-shaped projections 23b to come into contact with other members.
- the support 21 and the cone-shaped projection sheet 23 (that is, the cone-shaped projection sheet 3 with the support) are mounted on the seal sheet 9 in advance.
- the seal sheet 9 is attached to the cone-shaped projection molding sheet 7 in this state, the cone-shaped projection sheet 23 is disposed in the concave storage portion 31 a of the cone-shaped projection molding sheet 7.
- Body Conical projection sheet packaging 1 (an example of a conical projection sheet packaging) is a conical projection sheet 23 (cone An example of a body-like projection sheet), a cone-like projection molding sheet 7 (an example of a cone-like projection molding sheet), and a support 21 (an example of a support).
- the cone-shaped projection sheet 23 includes a base body 23a (an example of a base body) and a plurality of cone-shaped projections 23b (an example of a cone-shaped protrusion) formed on the surface of the base body 23a.
- the conical-projections forming sheet 7 includes a concave storage portion 31a (an example of a concave storage portion) in which the conical-projections sheet 23 is stored.
- the support 21 is fixed to the second surface of the base body 23 a of the cone-shaped projection sheet 23 and is further adhered to the cone-shaped projection forming sheet 7.
- a release agent 95 or 97 is applied in the portion of the cone-shaped projection forming sheet 7 to which the support 21 is adhered and a material having a release effect is used (a treatment for reducing the peel strength). An example) is given.
- the portion of the cone-shaped projection forming sheet 7 to which the support 21 is adhered has been subjected to a treatment for reducing the peel strength, so that the support 21 is adhered to the human body or other members. It is easy to peel the support 21 together with the cone-shaped projection sheet 23 from the cone-shaped projection molding sheet 7 without reducing the strength. Therefore, when the cone-shaped projection sheet 23 is taken out and used, the plurality of cone-shaped projections 23b are not easily damaged.
- a method for manufacturing the cone-shaped projection sheet package 1 includes the following steps. ⁇ Step of adhering the support 21 (an example of the support) to the seal sheet 9 (an example of the seal sheet) ⁇ In the cone-shaped projection molding sheet 7 (an example of the cone-shaped projection molding sheet), the support 21 is adhered Steps of applying release agents 95 and 97 to a portion to be applied and using a material having a release effect (an example of a process for reducing the peel strength) ⁇ Cone-shaped projection sheet 23 (conical shape) A step of placing an example of the protrusion sheet in the concave storage portion 31a (an example of the concave storage portion) of the cone-shaped projection molding sheet 7 A step of bonding the seal sheet 9 to the cone-shaped projection molding sheet 7 A cone The step of fixing the sheet-like projection sheet 23 to the support 21 The step of adhering the support 21 to the cone-shaped projection molding sheet 7 In this case, the support 21
- the support 21 Since the treatment for reducing the peel strength is applied to the part, the support 21 is attached together with the cone-shaped projection sheet 23 to the cone without reducing the strength of adhering the support 21 to the human body or other members. It becomes easy to peel off from the body-projection forming sheet 7. Therefore, when the cone-shaped projection sheet 23 is taken out from the cone-shaped projection molding sheet 7 and used, the plurality of cone-shaped projections 23b are not easily damaged. Note that the order of the steps is not limited unless specifically described. Moreover, each step may be performed simultaneously or partially overlapping.
- the timing at which the release agent 95 is applied is after completion of the blank of the cone-shaped projection forming sheet 7, but the timing at which the release agent 95 is applied is not particularly limited.
- FIG. 34 is a plan view of a conical-projection-sheet packing body as a sixth embodiment of the present invention.
- FIG. 35 is a cross-sectional view of XXXV-XXXV in FIG. 34, and is a cross-sectional view of a packing body of cone-shaped projection sheets.
- the packing body 101 of the cone-shaped projection sheet includes a cone-shaped projection sheet 105, a microneedle molding sheet 103, and a seal sheet 107.
- the molding sheet 103 and the seal sheet 107 are primary packaging materials for packaging the cone-shaped projection sheet 105.
- the package 101 is a primary package, and is a flat plate-shaped piece having a flat shape. Therefore, the degree of freedom of the subsequent secondary packaging is high. For example, vacuum packaging and design packaging are possible.
- seat accommodated in the primary packing material is single, However, The several cone-shaped projection sheet
- the cone-shaped projection sheet 105 is a member that is packed with the above-described primary packaging material and is taken out and used as necessary.
- the cone-shaped projection sheet 105 is a sheet-shaped article in which a plurality of microneedles 111 are formed on one surface.
- the cone-shaped projection sheet 105 has a thickness of about several hundred ⁇ m.
- the planar shape of the cone-shaped projection sheet 105 is smoothly curved as a whole, and has a crescent shape.
- the shape of the cone-shaped projection sheet 105 may be a circle, an ellipse, a triangle, a quadrangle, a square, or a slanted shape, and may be other shapes.
- the length is about several mm to several tens mm.
- the conical-projections sheet 105 includes a sheet-like base 110 and a plurality of microneedles 111.
- the plurality of microneedles 111 are formed on the lower surface (an example of the first surface) of the base 110.
- the cone-shaped projection sheet 105 is a patch for transdermal administration that is used, for example, to administer a drug or the like by sticking it so as to come into contact with human skin. Specifically, administration of a drug or the like is promoted by attaching the substrate 110 to the skin and the microneedles 111 piercing the skin.
- the cone-shaped protrusion sheet 105 is mainly composed of a water-soluble drug or a material obtained by adding a drug to a water-soluble polymer such as hyaluronic acid, water-soluble collagen, dextran, and chondroitin sulfate.
- a water-soluble polymer such as hyaluronic acid, water-soluble collagen, dextran, and chondroitin sulfate.
- the water-soluble polymer to which the drug is added is preferably a water-soluble polymer that is soluble in the living body, and sodium chondroitinate, hyaluronic acid, dextran, and the like are examples of the water-soluble polymer that is soluble in the living body. Can be mentioned.
- Water-soluble polymers include sodium chondroitin sulfate, hyaluronic acid, collagen (or hydrolyzed collagen), gelatin, glycogen, dextran, dextrin, dextran sulfate, cyclodextrin, chitosan, proteoglycan, pullulan, hydroxypropylcellulose, alginic acid, agarose , Glycogen, carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, and at least one substance selected from the group consisting of polyvinylpyrrolidone, polypinyl alcohol, and carboxyvinyl polymer. About these water-soluble polymers, only one may be used and you may use in combination of multiple types.
- the seal sheet 107 is a sheet for supporting or protecting the cone-shaped projection sheet 105, and is a material having good air permeability such as a nonwoven fabric.
- the seal sheet 107 is disposed above the base 110 of the cone-shaped projection sheet 105, and is further fixed to the upper surface of the molding sheet 103 at the periphery thereof. In FIG. 35, a gap is secured between the conical projection sheet 105 and the seal sheet 107. However, as described later, both may be fixed to each other.
- the seal sheet 107 includes a base material and an adhesive layer
- Nonwoven fabrics, stretchable cotton fabrics, sponge sheets, etc. can be used as the base material. These materials improve air permeability.
- vinyl chloride, urethane film, olefin film, and polyester film can also be used. Further, when a plurality of openings are provided in the base material, air permeability is improved.
- the adhesive layer is made of an acrylic adhesive or a silicon adhesive.
- the seal sheet 107 is fixed to the molding sheet 103 through an adhesive layer.
- the seal sheet 107 and the cone-shaped projection sheet 105 fixed to each other through the adhesive layer are peeled off from the molding sheet 103, and then the cone-shaped projection is formed together with the seal sheet 107.
- a sheet 105 is applied to the skin.
- the seal sheet 107 may be a member having aluminum and a resin layer. In that case, for example, combinations of the following layers are possible. (1) (surface side) / resin layer + design layer + aluminum + thermoadhesive resin layer / (case side) (2) (Surface side) / Resin layer + Aluminum + Thermal adhesive resin layer / (Case side) (3) (surface side) / resin layer + design layer + aluminum + resin layer + thermoadhesive resin layer / (case side) (4) (surface side) / resin layer + aluminum + resin layer + thermoadhesive resin layer / (case side) (5) (surface side) / resin layer + design layer + aluminum + resin layer + aluminum + thermoadhesive resin layer / (case side) (6) (Front side) / Aluminum + Resin layer + Aluminum + Thermal adhesive resin layer / (Case side) (7) (Surface side) / Aluminum + Thermal adhesive resin layer / (Case side) In addition, when aluminum is used for the seal sheet
- a sealing sheet contains an aluminum base material and a thermoadhesive resin layer
- the material for the heat-adhesive resin include polyethylene, ethylene / vinyl acetate copolymer, ionomer, polypropylene, and easily peelable heat-adhesive resin (EPR).
- EPR easily peelable heat-adhesive resin
- a design layer may be formed on the aluminum substrate. In that case, a design can be provided on the package.
- a resin layer may be formed on the aluminum substrate or the design layer. In that case, the aluminum substrate or the design layer is protected.
- the aluminum substrate may have a three-layer structure of aluminum + resin + aluminum. In that case, the sealing performance is improved.
- the heat-adhesive resin layer is heated and melted to adhere to the molding sheet 103.
- the seal sheet 107 is not fixed to the cone-shaped projection sheet 105.
- the seal sheet 107 is peeled off, then the cone-shaped projection sheet 105 is peeled off from the molding sheet 103, and finally the cone-shaped projection sheet 105 is detached alone. Apply to skin. Moreover, you may perform a lotion pack from the top of the cone-shaped projection sheet
- the above description of the seal sheet also applies to the seal sheets of other embodiments.
- the molding sheet 103 is a member for molding the microneedle 111 and protecting it after the molding.
- the molding sheet 103 is bonded to the lower surface of the cone-shaped projection sheet 105.
- a plurality of micro concave portions 113 for forming and storing the microneedles 111 of the cone-shaped projection sheet 105 are formed on the upper surface of the molding sheet 103.
- the micro recess 113 is a recess that opens upward, and does not penetrate the cone-shaped projection sheet 105.
- the molding sheet 103 is made of, for example, a polyolefin-based resin such as polyethylene or polypropylene in consideration of being used as a member for forming the plurality of micro concave portions 113. That is, the molding sheet 103 is preferably a hydrophobic sheet from which the pressure-sensitive adhesive can be re-peeled.
- FIGS. 36 and 37 a blank 1107 constituting the forming sheet 103 is prepared.
- FIG. 36 is a perspective view of a blank of a microneedle molding sheet.
- FIG. 37 is a cross-sectional view of a blank of a microneedle molding sheet.
- the blank 1107 has a bottom surface portion 1109 and a side surface portion 1111.
- the bottom surface portion 1109 is, for example, a rectangular flat plate portion.
- the side surface portion 1111 is a plate-like portion extending upward from the four sides of the bottom surface portion 1109, and forms a recess 1107a.
- a folded portion 1113 is formed at the upper end of the side surface portion 1111 over the entire circumference. The folded portion 1113 extends from the recess 1107a to the outer peripheral side and further extends downward in the cross section.
- FIG. 38 is a schematic diagram for explaining the preheating and forming steps.
- a heating chamber 141 a molding device 143, and a cooling chamber 145 are provided continuously.
- pre-molding preheating is performed on the blank 1107.
- the forming device 143 forms the micro concave portion 113 with respect to the blank 1107.
- the cooling chamber 145 the blank 1107 is cooled.
- the blank 1107 is conveyed between the apparatuses by a conveyor 146.
- the forming apparatus 143 is an apparatus for forming a plurality of fine micro concave portions 113 in the bottom surface portion 1109 of the blank 1107.
- the molding apparatus 143 is composed of a high precision press 147 and a needle-shaped press die (fine spike die) 149.
- the press die 149 has a press part 151.
- FIG. 39 is a cross-sectional view of the press die.
- the press portion 151 has a shape that matches the bottom surface portion 1109 of the blank 1107, and has a plurality of processing projections 153 on the lower surface.
- FIG. 40 is a schematic cross-sectional view showing a state before forming a blank.
- the blank 1107 is already soft when the press die 149 comes into contact with the bottom surface portion 1109 due to preheating before molding.
- a plurality of micro concave portions 113 are formed in the bottom surface portion 1109 by the processing projections 153.
- the press machine is controlled by a machine that can control the press location, pressing pressure, pressing time, etc. with high accuracy.
- processing time is required, it may also serve as a series of processes by heating and cooling the press die 149 itself.
- FIG. 41 is a schematic cross-sectional view showing a state after forming a blank.
- the micro concave portion 113 has, for example, a conical shape or a pyramid shape, and is open toward the upper side of the drawing.
- FIG. 42 is a schematic diagram for explaining a step of dropping a microneedle material onto a microneedle molding sheet. As shown in the figure, a dispenser 155 is provided.
- the dispenser 155 is a device that drops and fills the microneedle material 156 into the recess 1107a.
- the microneedle material 156 is, for example, sodium hyaluronate dissolved in a solvent made of water or the like. As the solvent, a medium in which water-soluble polymer is soluble in addition to water is selected. In this way, by supplying the microneedle material to the bottom surface portion 1109, the bottom surface portion 1109 is covered with the microneedle material 156 as shown in FIG.
- FIG. 43 is a schematic cross-sectional view of a microneedle molding sheet filled with a microneedle material.
- the microneedle material 156 does not penetrate into the micro concave portion 113, and therefore air may remain in the micro concave portion 113. In this case, a vacuum degassing step (not shown) May be added.
- FIG. 44 is a schematic diagram for explaining a process of drying the microneedle material.
- a drying furnace 165 is provided.
- the microneedle material 156 is heated and dried together with the blank 1107. Thereby, moisture and solvent material are evaporated from the microneedle material 156.
- the microneedle material 156 contracts by drying from the state of FIG. 45, and the volume is reduced to the position of FIG. In this state, the microneedle material 156 becomes the entire cone-shaped projection sheet 105 ⁇ / b> A having the plurality of microneedles 111.
- FIG. 45 is a schematic cross-sectional view of a microneedle molding sheet filled with a microneedle material before drying.
- FIG. 46 is a schematic cross-sectional view of a microneedle molding sheet filled with a microneedle material after drying.
- FIG. 48 is a cross-sectional view of a conical projection sheet forming protection structure preliminary body.
- FIGS. 48, FIG. 49, FIG. 51, FIG. 53, and FIG. 54 are schematic cross-sectional views for explaining a process of manufacturing a package from a conical-projection-sheet shaped protective structure preliminary body.
- 50, 52, and 55 are plan views of a preform for forming and protecting a cone-shaped projection sheet.
- a preliminary body 1101 is prepared in which an overall cone-shaped projection sheet 105A is formed on the bottom surface of the overall molding sheet 103A.
- a step of punching the entire cone-shaped projection sheet 105A so that a plurality of desired individual cone-shaped projection sheets 105 are formed and then removing unnecessary portions will be described.
- a cutting device 1141 is used.
- the cutting device 1141 has a press part 1142 and an annular cutting blade 1143.
- the cutting blade 1143 is provided on the lower surface of the press part 1142.
- the cutting blade 1143 has a shape corresponding to the outer periphery of the bottom surface portion of the overall molding sheet 103A.
- the cutting blade 1143 cuts the preliminary body 1101 to the lower surface.
- the side surface portion 1111 and the folded portion 1113 of the overall molding sheet 103A are cut off.
- the preliminary body 1101 becomes a planar sheet.
- a cutting die such as an etching blade, an engraving blade or a Thomson blade is used.
- a cutting device 1145 is used.
- the cutting device 1145 has a press part 1146 and a plurality of cutting blades 1147.
- Each cutting blade 1147 is provided on the lower surface of the press portion 1146.
- Each cutting blade 1147 is annular.
- FIG. 49 when the press part 1146 descends and approaches the preliminary body 1101, as shown in FIG.
- seat 105 is formed by cut
- the cutting blade 1147 does not reach the lower surface of the overall molding sheet 103A, that is, does not cut the overall molding sheet 103A (half cut). As a result, as shown in FIG.
- a plurality of conical projection sheets 105 punched into a shape corresponding to the plurality of cutting blades 1147 are obtained on the overall molding sheet 103A.
- 51 and 52 show the state after removing the waste, and the right side of FIG. 52 shows the waste 105B.
- a trace 66 is formed, which is a trace from which the plurality of cone-shaped projection sheets 105 have fallen off.
- an overall seal sheet 107A having a rectangular plane corresponding to the overall molding sheet 103A is fixed to each cone-shaped projection sheet 105. That is, the entire seal sheet 107A is bonded over the entire surface of the entire molding sheet 103A.
- the entire sealing sheet 107A is fixed to the entire molding sheet 3A around each individual cone-shaped projection sheet 105.
- the entire seal sheet 107A is affixed not only to the conical projection sheet 105 but also to the upper surface exposed portion of the overall molding sheet 103A. That is, in the step of fixing the entire seal sheet 107A, the entire seal sheet 107A is fixed to the entire molding sheet 3A around the individual cone-shaped projection sheet 105.
- a cutting device 1149 is used.
- the cutting device 1149 has a press part 1150 and a plurality of cutting blades 1151.
- the cutting blade 1151 is provided on the lower surface of the press unit 150.
- Each cutting blade 1151 is annular and has a larger diameter than the cutting blade 1147.
- the cutting blade 1151 cuts the overall molding sheet 103A and the overall seal sheet 107A to the lower surface at the outer periphery of the individual cone-shaped projection sheet 105. To do.
- a plurality of packing bodies 101 are obtained.
- the right side of FIG. 55 is the waste 107B.
- a drop 167 is formed, which is a mark from which the plurality of packing bodies 101 have dropped out.
- the cone-shaped projection sheet 105 is formed on the molding sheet 103, and the state when formed is maintained. Specifically, the plurality of microneedles 111 of the cone-shaped projection sheet 105 are formed by the plurality of micro concave portions 113 of the molding sheet 103 and are protected by the plurality of micro concave portions 113 thereafter. That is, the plurality of microneedles 111 of the cone-shaped projection sheet 105 are reliably protected. Moreover, since this package 101 has the sealing sheet 107 fixed to the sheet
- a plurality of cone-shaped projection sheet packages 101 are formed at a time by the final product punching step (FIG. 54). Therefore, mass production is possible with a small number of processes. Further, in this manufacturing method, since the whole seal sheet 107A is fixed to the whole molding sheet 103A around the individual cone-like projection sheet 105, the final product punching step is performed to surround the individual cone-like projection sheet 105. The individual seal sheet 107 can be fixed to the individual molding sheet 103. Thereby, the individual cone-shaped projection sheet
- the cone-shaped projection sheet 105 is fixed to the molding sheet 103 by the seal sheet 107 in a state where the package 101 of the cone-shaped projection sheet is completed.
- the microneedle 111 is protected when the package 101 of the cone-shaped projection sheet is conveyed or used.
- the molding sheet 103 functions as a molding die for forming the microneedles 111 of the cone-shaped projection sheet 105. Further, the molding sheet 103 functions as a protective material that protects the microneedles 111 of the cone-shaped projection sheet 105.
- the present invention can be widely applied to a conical-projection-sheet packaging body including a plurality of conical-projections and a manufacturing method thereof.
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Abstract
Description
この場合、錐体状突起シートの複数の錐体状突起は、錐体状突起成形用シートの複数の錐体状凹部によって形成され、その後も複数の錐体状凹部によって保護された状態が維持される。つまり、錐体状突起シートの錐体状突起が確実に保護される。
また、錐体状突起シートが錐体状突起成形用シートとシールシートとの間に密封されるので、錐体状突起シートの品質が長く維持される。以上に述べたように、錐体状突起成形用シートがシールシートとともに梱包体を構成する部材として用いられているので、複数の錐体状突起を確実に保護しつつ、錐体状突起シートの梱包体の部品点数を減らすことができる。
錐体状突起成形用シートは、複数の錐体状凹部が形成された凹状収納部を有しており、錐体状突起シートは、凹状収納部内に配置されていてもよい。
この場合、支持体が錐体状突起成形用シートに粘着されることで、錐体状突起シートの複数の錐体状突起が錐体状突起成形用シートの複数の錐体状凹部内に配置された状態が維持される。さらに、支持体を錐体状突起成形用シートから剥がすと、錐体状突起シートが支持体と共に錐体状突起成形用シートから離れることができる。
この場合、錐体状突起成形用シートにおいて支持体が粘着される部分には剥離強度を低減するための処理が施されているので、支持体を人体又は他の部材に粘着する強度を低下させることなく、支持体を錐体状突起シートと共に錐体状突起成形用シートから剥がすのが容易になる。したがって、錐体状突起シートを取り出して使用する際に複数の錐体状突起が破損しにくい。
◎錐体状突起成形用シートに複数の錐体状凹部を形成するステップ
◎錐体状突起成形用シートに錐体状突起材料を供給することで、基体と基体の表面に形成されかつ複数の錐体状凹部内に配置された複数の錐体状突起とを有する錐体状突起シートを形成するステップ
◎シールシートを錐体状突起成形用シートに固定することで錐体状突起シートを錐体状突起成形用シートとシールシートとの間で密封するステップ
この製造方法では、錐体状突起シートは錐体状突起成形用シートに形成され、その状態を維持される。具体的には、錐体状突起シートの複数の錐体状突起は錐体状突起成形用シートの複数の錐体状凹部によって形成され、その後も複数の錐体状凹部によって保護されている。つまり、錐体状突起シートの複数の錐体状突起が確実に保護される。
製造方法は、複数の錐体状凹部を形成する前に、錐体状突起成形用シートに複数の錐体状凹部が形成される箇所に凹状収納部を形成するステップをさらに備えていてもよい。その場合、錐体状突起シートを形成するステップでは、錐体状突起シートは凹状収納部内に形成される。
この場合、支持体が錐体状突起成形用シートに粘着されることで、錐体状突起シートの複数の錐体状突起が錐体状突起成形用シートの複数の錐体状凹部内に配置された状態が維持される。さらに、支持体を錐体状突起成形用シートから剥がすと、支持体と共に錐体状突起シートが錐体状突起成形用シートから離れる。
◎錐体状突起シートを形成するステップの前に、錐体状突起成形用シートにおいて支持体が粘着される部分に剥離強度を低減するための処理を施すステップ
この場合、錐体状突起成形用シートにおいて支持体が粘着される部分には、剥離強度を低減するための処理が施されているので、支持体を人体又は他の部材に粘着する強度を低下させることなく、支持体を錐体状突起シートと共に錐体状突起成形用シートから剥がすのが容易になる。したがって、錐体状突起シートを錐体状突起成形用シートから取り出して使用する際に複数の錐体状突起が破損しにくい。
なお、前記ステップの順番は特別に記載している場合を除いて限定されない。また、各ステップは同時に又は一部重なって行われてもよい。
(1)錐体状突起シートの梱包体
図1及び図2を用いて、第1実施形態の錐体状突起シートの梱包体1を説明する。図1は、本発明の第1実施形態としての錐体状突起シートの梱包体の部分平面図である。図2は、図1のII-II断面図である。
錐体状突起シートの梱包体1は、複数の支持体付き錐体状突起シート3と、支持体付き錐体状突起シート3を包装する梱包材5とから構成されている。なお、以下の実施形態では錐体状突起シートの梱包体1内には複数の支持体付き錐体状突起シート3が収納されているが、支持体付き錐体状突起シート3は単数であってもよい。
支持体付き錐体状突起シート3は、梱包材5によって梱包され、必要に応じて取り出されて使用される部材である。支持体付き錐体状突起シート3は、シート形状の物品であり、主に、支持体21と、錐体状突起シート23とから構成されている。
錐体状突起シート23は、後述する複数の錐体状突起が一面に形成されたシート形状の物品である。錐体状突起シート23は、厚みが数百μm程度である。錐体状突起シート23の平面形状は、全体がなめらかに湾曲しており、幅が広い部分と幅が狭い部分を有する勾玉形状である。錐体状突起シート23の形状は、円、楕円、三角形、四角形、正方形、その他の形状でもよい。錐体状突起シート23は、例えば、四角形の場合は、一辺数mmから数十mm程度である。
なお、水溶性高分子は、コンドロイチン硫酸ナトリウム、ヒアルロン酸、コラーゲン(又は加水分解コラーゲン)、ゼラチン、グリコーゲン、デキストラン、デキストリン、デキストラン硫酸、シクロデキストリン、キトサン、プロテオグリカン、プルラン、ヒドロキシプロピルセルロース、アルギン酸、アガロース、グリコーゲン、カルボキシメチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、及びポリビニルピロリドン、ポリピニルアルコール、カルボキシビニルポリマーからなる群より選ばれた少なくとも1つの物質からなる。これらの水溶性高分子については、1つだけを用いてもよいし、複数種を組み合わせて用いてもよい。
なお、第1粘着層26は、第1シート25の下面において第2シート27よりさらに外周側の部分にも設けられている。したがって、第1粘着層26によって、支持体21(つまり、支持体付き錐体状突起シート3)は、錐体状突起成形用シート7に固定されている。
梱包材5は、支持体付き錐体状突起シート3を梱包するための部材である。梱包材5は、錐体状突起成形用シート7と、シールシート9とを有しており、両シートが張り合わされることで支持体付き錐体状突起シート3を梱包している。
錐体状突起成形用シート7は、シート状の部材であり、支持体付き錐体状突起シート3を収納するための複数の収納部31を有している。収納部31は梱包材5の外側に向かって膨張した凸形状であり、梱包材5の内側には凹状収納部31aを形成している。凹状収納部31aの平面形状は、支持体付き錐体状突起シート3の平面形状と同じである。凹状収納部31aは、底面33と、その周囲にあり底面33より高い環状の段差面35とから構成されている。凹状収納部31aの周囲(すなわち段差面35の周囲)には、平坦面37が設けられている。このように収納部31の凹状の凹状収納部31aは、底面33、環状の段差面35、及び平坦面37によって階段状になっている。環状の段差面35には、前述したように、支持体21の外周部が第1粘着層26を介して粘着されている。なお、段差面35には、支持体21の外周部が剥がれやすくなるように離型剤が塗布されていてもよい。
表面樹脂層41は、印刷可能であり、さらに金属層43を保護する機能も有している。
金属層43は、表面樹脂層41の下面に設けられている。金属層43は、アルミニウム又はその合金からなり、防湿性が高い。
このようにして、シールシート9は、錐体状突起シート23を覆った状態で錐体状突起成形用シート7の内側の面に貼り合わされて、両者によって凹状収納部31aを密封している。
次に、使用者は、図4に示すように、支持体付き錐体状突起シート3をシールシート9から剥がす。図4は、支持体付き錐体状突起シートをシールシートから剥がした状態を示す断面図である。この結果、使用者は、支持体付き錐体状突起シート3を目的に応じて使用できるようになる。経皮投与用貼付剤の場合は、支持体付き錐体状突起シート3は人の皮膚に貼られる。その場合、支持体21が第1粘着層26によって皮膚に貼られ、錐体状突起シート23の錐体状突起23bが皮膚に接触する。
図5~図16を用いて、錐体状突起シートの梱包体1の製造方法を説明する。以下複数の製造プロセスを説明する。
最初に、錐体状突起成形用シート7を構成するブランクを用意する。図5は、錐体状突起成形用シートのブランクの断面図である。図から明らかなように、錐体状突起成形用シート7には、予め複数の収納部31が形成されている。収納部31の形成は、真空成形、真空圧空成形又は冷間成形によって行われる。例えば、複数の凹状の収納部31を成形するために1以上のパンチ工具を用いて平坦なシートを工具型上部から押し込んで、形状がパンチ形状の凹部に相当する凹形状工具型にて凹形状が形成される条件下にて作成することができる。
第1に、錐体状突起成形用シート7は、錐体状突起シート23の錐体状突起23bを形成するための成形型として機能している。
第2に、錐体状突起成形用シート7は、錐体状突起シート23の錐体状突起23bを保護する保護材として機能している。
(1)錐体状突起シートの梱包体の構造
錐体状突起シートの梱包体1(錐体状突起シートの梱包体の一例)は、錐体状突起シート23(錐体状突起シートの一例)と、錐体状突起成形用シート7(錐体状突起成形用シートの一例)と、シールシート9(シールシートの一例)を備えている。錐体状突起シート23は、基体23a(基体の一例)と、その表面23cに形成された複数の錐体状突起23b(複数の錐体状突起の一例)とを有する。錐体状突起成形用シート7は、複数の錐体状突起23bを形成するのに用いられかつ錐体状突起23bが配置された複数の錐体状凹部33a(錐体状凹部の一例)を有しており、錐体状突起シート23の表面23cに密着した状態で錐体状突起シート23を保護する。シールシート9は、錐体状突起成形用シート7に固定されることで錐体状突起シート23を錐体状突起成形用シート7との間で密封する。
また、錐体状突起シート23が錐体状突起成形用シート7とシールシート9との間に密封されるので、錐体状突起シート23の品質が長く維持される。以上に述べたように、錐体状突起成形用シート7がシールシート9とともに梱包体を構成する部材として用いられているので、複数の錐体状突起23bを確実に保護しつつ、錐体状突起シートの梱包体1の部品点数を減らすことができる。
錐体状突起シートの梱包体1の製造方法は、以下のステップを備えている。
◎錐体状突起成形用シート7に複数の錐体状凹部33aを形成するステップ(図7~図10Bを参照。)
◎錐体状突起成形用シート7に錐体状突起材料を供給することで、基体23aとその表面23cに形成されかつ複数の錐体状凹部33a内に配置された複数の錐体状突起23bとを有する錐体状突起シート23を形成するステップ(図11~図12を参照。)
◎シールシート9を錐体状突起成形用シート7に固定することで錐体状突起シート23を錐体状突起成形用シート7とシールシート9との間で密封するステップ
また、錐体状突起シート23が錐体状突起成形用シート7とシールシート9との間に密封されるので、錐体状突起シート23の品質が長く維持される。以上に述べたように、錐体状突起成形用シート7がシールシート9とともに梱包体を構成する部材として用いられているので、複数の錐体状突起23bを確実に保護しつつ、錐体状突起シートの梱包体1の部品点数を減らすことができる。
以上、本発明の第1実施形態について説明したが、本発明は上記実施形態に限定されるものではなく、発明の要旨を逸脱しない範囲で種々の変更が可能である。特に、本明細書に書かれた複数の実施形態及び変形例は必要に応じて任意に組み合せ可能である。
(a)前記実施形態では支持体を錐体状突起成形用シートに装着するときに支持体はあらかじめシールシートに固定されておりシールシートと共に錐体状突起成形用シートに装着されていた。しかし、支持体はシールシートとは別に準備されており一枚ずつ錐体状突起成形用シートに装着されてもよい。
(b)前記実施形態では支持体は2枚のシート(第1シート25、第2シート27)から構成されていたが、支持体は1枚のシートから構成されていてもよい。
(e)前記実施形態では錐体状突起成形用シート7において複数の錐体状凹部33aが形成された場所は凹状収納部31aの底面33であったが、複数の錐体状凹部は凹部以外の部分に形成されてもよい。例えば、錐体状突起成形用シートが平坦な部材であり、その表面に複数の錐体状凹部が形成されてもよい。
(f)前記実施形態では支持体21を第1粘着層26によって錐体状突起成形用シート7に対して固定することで、錐体状突起シート23を底面33に密着させそれにより錐体状突起23bが錐体状凹部33aに保護された状態を維持したが、他の手段で錐体状突起シートを底面に密着させてもよいし、特別な手段を講じずに両者を密着させていてもよい。
以下、第2実施形態を説明する。第2実施形態は第1実施形態と基本的な構成及び製造方法が同じである。したがって、以下の説明では異なる点を中心に説明する。
(1)錐体状突起シートの梱包体
錐体状突起シートの梱包体1は、概ね第1実施形態と同じである。
支持体付き錐体状突起シート3は、概ね第1実施形態と同じである。
梱包材5は、概ね第1実施形態と同じである。
なお、この実施形態では、離型剤95は、段差面35の内周側にある筒状面(底面33につながる面)及び段差面35の外周側にある筒状面(平坦面37につながる面)にも形成されている。ただし、離型剤95は、錐体状突起シート23との接触を避けることを目的として、底面33には塗布されていない。
なお、前述のように錐体状突起成形用シート7において支持体21が粘着される部分に施された剥離強度を低減するための処理として段差面35には離型剤95が塗布されているので、支持体21の外周部(第1粘着層26により固定されている部分)は、錐体状突起成形用シート7から容易に剥がすことができる。具体的には、支持体21と錐体状突起成形用シート7との剥離強度は、0.5~4.0(N/10mm)であり、好ましくは0.5~2.0(N/10mm)である。
表面樹脂層41は、印刷可能であり、さらに金属層43を保護する機能も有している。
金属層43は、表面樹脂層41の下面に設けられている。金属層43は、アルミニウム又はその合金からなり、防湿性が高い。
このようにして、シールシート9は、錐体状突起シート23を覆った状態で錐体状突起成形用シート7の内側の面に貼り合わされて、両者によって凹状収納部31aを密封している。
錐体状突起シートの梱包体1の製造方法は、概ね第1実施形態と同じである。なお、本実施形に対応する図面として、図9B、図10、図11B、図13、図16、図17を添付する。
最初に、錐体状突起成形用シート7を構成するブランクを用意する。図21は、錐体状突起成形用シートのブランクの断面図である。図から明らかなように、錐体状突起成形用シート7には、予め複数の収納部31が形成されている。収納部31の形成は、真空成形、真空圧空成形又は冷間成形によって行われる。例えば、複数の凹状の収納部31を成形するために1以上のパンチ工具を用いて平坦なシートを工具型上部から押し込んで、形状がパンチ形状の凹部に相当する凹形状工具型にて凹形状が形成される条件下にて作成することができる。
図25は、錐体状凹部が形成された後の錐体状突起成形用シートの部分断面図である。図に示すように、錐体状凹部33aは、例えば円錐形状又は角錐形状であり、図上側に向かって開いている。
図26に示すように、底面33が錐体状突起材料23Aによって覆われる。図26は、錐体状突起材料が充填された錐体状突起成形用シートの部分断面図である。
図27及び図28に示すように、前述のシールシート9には、あらかじめ所定位置に複数の支持体21が装着されている。つまり、支持体21はシールシート9が錐体状突起成形用シート7に仮止めされるときに同時に錐体状突起成形用シート7に装着される。また、シールシート9には、第2接着層44が設けられており、それが錐体状突起成形用シート7の平坦面37に固定される。図27は、シールシートと錐体状突起成形用シートの断面図である。図28は、シールシートを錐体状突起成形用シートに仮固定した状態の断面図である。シールシート9が錐体状突起成形用シート7に固定された状態では、支持体21は、凹状収納部31a内に挿入され、その結果錐体状突起シート23に近接する。しかし、このとき、図28に示すように、支持体21の第2シート27と錐体状突起シート23との間には隙間が確保されており、さらには支持体21の第1シート25と段差面35との間には隙間が確保されている。
第2実施形態では離型剤は段差面35及びその半径方向両側にある筒状面にも塗布されていたが、離型剤は支持体21が粘着される部部分のみに形成されていればよい。
以下、図29を用いて、第3実施形態を説明する。図29は、第3実施形態における錐体状突起シートの梱包体の断面図である。
この実施形態では、離型剤97は、段差面35のみに塗布されている。なお、離型剤は段差面35の全てに塗布されている必要はなく、支持体21が粘着される部分にのみ塗布されていればよい。
第2実施形態では錐体状突起成形用シートにおいて支持体が粘着される部分に施す剥離強度を低減するための処理として離型剤が塗布されていたが、他の手段によって剥離強度を低下させてもよい。
以下、図30を用いて、第4実施形態を説明する。図30は、第4実施形態における錐体状突起シートの梱包体の断面図である。
この実施形態では、段差面35には離型剤は塗布されておらず、代わりに離型性を向上させるための材料が錐体状突起成形用シート7に採用されている。そのような材料としては、例えば、離型効果のあるポリエチレン(PE)樹脂、ポリプロピレン(PP)樹脂、ポリエチレンテレフタラート(PET)、ポリスチレン(PS)がある。この順番において、前の樹脂である方が後の樹脂であるより好ましい。
さらに、離型効果を高めるために、段差面35にはエンボス加工を施すことで、粘着剤の接触面積を減らして、離型効果を上げることもできる。図31A~図31Cを用いて、段差面35にエンボス加工を行う実施例を説明する。図31A~図31Cは、段差面にエンボス加工を行う工程を示す模式図である。図31A~図31Cに示すように、成形金型205は、凹状収納部31aに対する凸部205aと、段差面35に対応するエンボス加工部205bと有する成形金型205が用いられる。この成形金型205を、図31Bに示すようにトレー樹脂材料207に押しつけると、凹状収納部31a及び段差面35が形成される。また、段差面35にエンボス加工が行われる。その結果、図31Cに示すように、段差面35にエンボス加工面35aが形成される。
なお、離型効果のある材料を用いた上で離型剤を塗布することも可能である。その場合はさらに離型効果が高くなる。
第2実施形態では錐体状突起シート23は錐体状突起成形用シート7を型として成形されていたが、錐体状突起シート23は他の装置で製造されてから錐体状突起成形用シート7の凹状収納部31aに配置されてもよい。
以下、図32及び図33を用いて、第5実施形態を説明する。図32は、第5実施形態における錐体状突起シートの梱包体の断面図である。図33は、第5実施形態において、シールシートを錐体状突起成形用シートに仮固定する工程を説明するための模式図である。
(1)錐体状突起シートの梱包体の構造
錐体状突起シートの梱包体1(錐体状突起シートの梱包体の一例)は、錐体状突起シート23(錐体状突起シートの一例)と、錐体状突起成形用シート7(錐体状突起成形用シートの一例)と、支持体21(支持体の一例)とを備えている。錐体状突起シート23は、基体23a(基体の一例)と基体23aの表面に形成された複数の錐体状突起23b(錐体状突起の一例)とを有する。錐体状突起成形用シート7は、錐体状突起シート23が収納された凹状収納部31a(凹状収納部の一例)を有する。支持体21は、錐体状突起シート23の基体23aの第2の表面に固定されさらに錐体状突起成形用シート7に粘着される。錐体状突起成形用シート7において支持体21が粘着される部分には、離型剤95、97を塗布すること及び離型効果を有する材料を用いること(剥離強度を低減するための処理の一例)が施されている。
この場合、錐体状突起成形用シート7において支持体21が粘着される部分には、剥離強度を低減するための処理が施されているので、支持体21を人体又は他の部材に粘着する強度を低下させることなく、支持体21を錐体状突起シート23と共に錐体状突起成形用シート7から剥がすのが容易になる。したがって、錐体状突起シート23を取り出して使用する際に複数の錐体状突起23bが破損しにくい。
錐体状突起シートの梱包体1(錐体状突起シートの梱包体の一例)の製造方法は、下記のステップを備えている。
◎支持体21(支持体の一例)をシールシート9(シールシートの一例)に粘着するステップ
◎錐体状突起成形用シート7(錐体状突起成形用シートの一例)において支持体21が粘着される部分に離型剤95、97を塗布すること及び離型効果を有する材料を用いること(剥離強度を低減するための処理の一例)を施すステップ
◎錐体状突起シート23(錐体状突起シートの一例)を錐体状突起成形用シート7の凹状収納部31a(凹状収納部の一例)に配置するステップ
◎シールシート9を錐体状突起成形用シート7に貼り合わせるステップ
◎錐体状突起シート23を支持体21に固定するステップ
◎支持体21を錐体状突起成形用シート7に粘着するステップ
この場合、錐体状突起成形用シート7において支持体21が粘着される部分には、剥離強度を低減するための処理が施されているので、支持体21を人体又は他の部材に粘着する強度を低下させることなく、支持体21を錐体状突起シート23と共に錐体状突起成形用シート7から剥がすのが容易になる。したがって、錐体状突起シート23を錐体状突起成形用シート7から取り出して使用する際に複数の錐体状突起23bが破損しにくい。
なお、前記ステップの順番は特別に記載している場合を除いて限定されない。また、各ステップは同時に又は一部重なって行われてもよい。
以上、本発明の第2~第5実施形態について説明したが、本発明は上記実施形態に限定されるものではなく、発明の要旨を逸脱しない範囲で種々の変更が可能である。特に、本明細書に書かれた複数の実施形態及び変形例は必要に応じて任意に組み合せ可能である。
(a)第2実施形態では支持体21を錐体状突起成形用シート7に装着するときに支持体21はあらかじめシールシート9に固定されておりシールシート9と共に錐体状突起成形用シート7に装着されていた。しかし、支持体はシールシートとは別に準備されており一枚ずつ錐体状突起成形用シートに装着されてもよい。
(b)第2実施形態では支持体21は2枚のシート(第1シート25、第2シート27)から構成されていたが、支持体は1枚のシートから構成されていてもよい。
第1実施形態の変形例として、錐体状突起成形用シートが平坦な部材であり、その表面に複数の錐体状凹部が形成された実施形態を説明する。
(1)錐体状突起シートの梱包体
図34及び図35を用いて、第6実施形態の錐体状突起シートの梱包体1を説明する。図34は、本発明の第6実施形態としての錐体状突起シートの梱包体の平面図である。図35は、図34のXXXV-XXXV断面図であり、錐体状突起シートの梱包体の断面図である。
なお、以下の実施形態では一次梱包材内に収納されている錐体状突起シートは単数であるが、複数の錐体状突起シートが収納されていてもよい。
錐体状突起シート105は、前述の一次梱包材によって梱包され、必要に応じて取り出されて使用される部材である。錐体状突起シート105は、複数のマイクロニードル111が一面に形成されたシート形状の物品である。錐体状突起シート105は、厚みが数百μm程度である。錐体状突起シート105の平面形状は、図34に示すように、全体がなめらかに湾曲しており、三日月形状である。錐体状突起シート105の形状は、円、楕円、三角形、四角形、正方形、勾玉形状でその他の形状でもよい。錐体状突起シート105は、例えば、四角形の場合は、一辺数mmから数十mm程度である。
シールシート107は、錐体状突起シート105を支持又は保護するためのシートであり、例えば不織布のような通気性の良い材料である。シールシート107は、錐体状突起シート105の基体110の上方に配置され、されさらにその周囲において成形用シート103の上面に固定されている。なお、図35では、錐体状突起シート105とシールシート107との間に隙間が確保されている。ただし、後述するように両者は互いに固定されていてもよい。
シールシート107は粘着層を介して成形用シート103に固定される。錐体状突起シート105を肌に貼る時は、粘着層を介して互いに固定されたシールシート107と錐体状突起シート105を成形用シート103から剥がして、その後シールシート107とともに錐体状突起シート105を肌に貼る。
(1)(表面側)/樹脂層+意匠層+アルミ+熱接着性樹脂層/(ケース側)
(2)(表面側)/樹脂層+アルミ+熱接着性樹脂層/(ケース側)
(3)(表面側)/樹脂層+意匠層+アルミ+樹脂層+熱接着性樹脂層/(ケース側)
(4)(表面側)/樹脂層+アルミ+樹脂層+熱接着性樹脂層/(ケース側)
(5)(表面側)/樹脂層+意匠層+アルミ+樹脂層+アルミ+熱接着性樹脂層/(ケース側)
(6)(表面側)/アルミ+樹脂層+アルミ+熱接着性樹脂層/(ケース側)
(7)(表面側)/アルミ+熱接着性樹脂層/(ケース側)
なお、シールシート107にアルミニウムを用いると、梱包体の状態での錐体状突起シート105の密封性が上がり、そのためマイクロニードルが吸湿性の高い材料でできていても保護できる。
アルミ基材と熱接着性樹脂との間に樹脂層があってもよい。その場合は、アルミ基材の耐久性が上がる。
アルミ基材の上に意匠層を形成してもよい。その場合は、梱包体に意匠を設けることができる。
アルミ基材はアルミ+樹脂+アルミの3層構造であってもよい。その場合は、密封性が向上する。
錐体状突起シート105を肌に貼るときは、最初にシールシート107を剥がして、次に錐体状突起シート105を成形用シート103から剥がして、最後に錐体状突起シート105を単体で肌に貼る。また、その後、錐体状突起シート105の上から化粧水パックを行ってもよい。
また、上記のシールシートの説明は,他の実施形態のシールシートにも当てはまる。
成形用シート103は、マイクロニードル111を成形するとともに成形後に保護するための部材である。成形用シート103は、錐体状突起シート105の下面に張り合わされている。また、図35に示すように、成形用シート103の上面には、錐体状突起シート105のマイクロニードル111を形成かつ収納するための複数のマイクロ凹部113が形成されている。なお、マイクロ凹部113は、上方に向かって開いた凹みであり、錐体状突起シート105を貫通していない。
成形用シート103は、複数のマイクロ凹部113を形成する部材として用いられることを考慮して、例えば、ポリエチレンやポリプロピレンなどのポリオレフィン系樹脂からなる。つまり、成形用シート103は、粘着剤が再剥離可能な疎水性シートであることが好ましい。
以下、ブランク1107(全体成形用シート103A)に複数のマイクロ凹部113を形成するステップを説明する。
最初に、図36及び図37に示すように、成形用シート103を構成するブランク1107を用意する。図36は、マイクロニードル成形用シートのブランクの斜視図である。図37は、マイクロニードル成形用シートのブランクの断面図である。図から明らかなように、ブランク1107は、底面部1109と、側面部1111とを有している。底面部1109は、例えば、四角形の平坦な板状部分である。側面部1111は、底面部1109の四辺から上方に延びる板状部分であり、凹部1107aを形成している。なお、側面部1111の上端には、全周にわたって折り返し部1113が形成されている。折り返し部1113は、断面において、凹部1107aから外周側に延びさらに下方に延びている。
加熱室141では、ブランク1107に対して成形前予備加熱が行われる。成形装置143は、ブランク1107に対してマイクロ凹部113を成形する。冷却室145では、ブランク1107に対して冷却が行われる。ブランク1107は、各装置の間をコンベア146によって搬送される。
図41は、ブランクの成形後の状態を示す模式的断面図である。図に示すように、マイクロ凹部113は、例えば円錐形状又は角錐形状であり、図上側に向かって開いている。
図42~図43を用いて、ブランク1107にマイクロニードル材料156を供給する工程を説明する。図42は、マイクロニードル成形用シートにマイクロニードル材料を滴下する工程を説明するための模式図である。図に示すように、分注機155が設けられている。分注機155は、マイクロニードル材料156を凹部1107aに滴下充填する装置である。マイクロニードル材料156は、例えば、水などからなる溶媒に溶けたヒアルロン酸ナトリウムである。なお、溶媒としては、水の他、水溶性高分子が可溶する媒体が選択される。このように、底面部1109にマイクロニードル材料を供給することで、図43に示すように、底面部1109がマイクロニードル材料156によって覆われる。図43は、マイクロニードル材料が充填されたマイクロニードル成形用シートの模式的断面図である。なお、この実施形態では、マイクロニードル材料156はマイクロ凹部113内までは侵入しておらず、そのためマイクロ凹部113に空気が残っている場合があり、その場合は減圧脱気工程(図示せず)を追加してもよい。
以下、図48~図55を用いて梱包体101の製造方法を説明する。
図48、図49、図51、図53及び図54は、錐体状突起シートの成形保護構造予備体から梱包体を製造する工程を説明するための模式的断面図である。図50、図52、図55は、錐体状突起シートの成形保護構造予備体の平面図である。
以下、全体錐体状突起シート105Aを所望の複数の個別錐体状突起シート105が形成されるように打ち抜いて、次に不要部分を除去するステップを説明する。
図53に示すように、全体成形用シート103Aに対応した平面が四角形状の全体シールシート107Aを各錐体状突起シート105に固定する。つまり、全体成形用シート103Aの全面にわたって、全体シールシート107Aが貼り合わされる。そして、各個別錐体状突起シート105の周囲において全体シールシート107Aが全体成形用シート3Aに固定される。
図54に示すように、切断装置1149が用いられる。切断装置1149は、プレス部1150と、複数の切断刃1151とを有している。切断刃1151は、プレス部150の下面に設けられている。各切断刃1151は、環状であり、切断刃1147より径が大きい。プレス部1150が下降して全体成形用シート103A及び全体シールシート107Aに接近すると、切断刃1151が、個別錐体状突起シート105の外周において全体成形用シート103A及び全体シールシート107Aを下面まで切断する。この結果、図55左側の図に示すように、複数の梱包体101が得られる。なお、図55の右側の図は廃棄物107Bである。廃棄物107Bでは、複数の梱包体101が抜け落ちた跡である抜け跡167が形成されている。
また、この梱包体101は、錐体状突起シート105に対応して成形用シート103に固定されたシールシート107を有しているので、個別錐体状突起シート105が保護される。
さらに、この製造法では、全体シールシート107Aは個別錐体状突起シート105の周囲において全体成形用シート103Aに固定されているので、最終の製品打ち抜きステップによって、個別錐体状突起シート105の周囲において個別シールシート107を個別成形用シート103に固定した状態にできる。これにより、個別錐体状突起シート105が外部からの汚染から保護される。
3 :支持体付き錐体状突起シート
5 :梱包材
7 :錐体状突起成形用シート
9 :シールシート
21 :支持体
23 :錐体状突起シート
23a :基体
23b :錐体状突起
23c :表面
31 :収納部
31a :凹状収納部
33 :底面
33a :錐体状凹部
35 :段差面
37 :平坦面
Claims (12)
- 基体と前記基体の表面に形成された複数の錐体状突起とを有する錐体状突起シートと、
前記複数の錐体状突起を形成するのに用いられかつ前記複数の錐体状突起が配置された複数の錐体状凹部を有しており、前記基体の前記表面に密着した状態で前記複数の錐体状突起を保護する錐体状突起成形用シートと、
前記錐体状突起成形用シートに固定されることで前記錐体状突起シートを前記錐体状突起成形用シートとの間で密封するシールシートと、
を備えている、錐体状突起シートの梱包体。 - 前記錐体状突起成形用シートは、前記複数の錐体状凹部が形成された凹状収納部を有しており、
前記錐体状突起シートは、前記凹状収納部内に配置されている、請求項1に記載の錐体状突起シートの梱包体。 - 前記錐体状突起シートの前記基体の第2の表面に固定されさらに前記錐体状突起成形用シートに粘着されることで、前記錐体状突起シートの前記複数の錐体状突起が前記錐体状突起成形用シートの前記複数の錐体状凹部内に配置された状態を維持する支持体をさらに備える、請求項1又は2に記載の錐体状突起シートの梱包体。
- 前記錐体状突起成形用シートにおいて前記支持体が粘着される部分には、剥離強度を低減するための処理が施されている、請求項3に記載の錐体状突起シートの梱包体。
- 前記剥離強度を低減するための処理とは、離型剤を塗布すること及び離型効果を有する材料を用いることの一方又は両方である、請求項4に記載の錐体状突起シートの梱包体。
- 前記支持体と前記シールシートの剥離強度は2.0~6.5(N/10mm)である、請求項4又は5に記載の錐体状突起シートの梱包体。
- 前記支持体と前記錐体状突起成形用シートの剥離強度は0.5~4.0(N/10mm)である、請求項4~6のいずれかに記載の錐体状突起シートの梱包体。
- 錐体状突起成形用シートに複数の錐体状凹部を形成するステップと、
前記錐体状突起成形用シートに錐体状突起材料を供給することで、基体と前記基体の表面に形成されかつ前記複数の錐体状凹部内に配置された複数の錐体状突起とを有する錐体状突起シートを形成するステップと、
シールシートを前記錐体状突起成形用シートに固定することで前記錐体状突起シートを前記錐体状突起成形用シートと前記シールシートとの間で密封するステップと、
備えている、錐体状突起シートの梱包体の製造方法。 - 前記複数の錐体状凹部を形成する前に、前記錐体状突起成形用シートに前記複数の錐体状凹部が形成される箇所に凹状収納部を形成するステップをさらに備えており、
前記錐体状突起シートを形成するステップでは、前記錐体状突起シートは前記凹状収納部内に形成される、請求項8に記載の錐体状突起シートの梱包体の製造方法。 - 支持体を前記錐体状突起シートの前記基体の第2の表面に固定しさらに前記錐体状突起成形用シートに粘着することで、前記錐体状突起シートの前記複数の錐体状突起が前記錐体状突起成形用シートの前記複数の錐体状凹部内に配置された状態を維持するステップをさらに備えている、請求項8又は9に記載の錐体状突起シートの梱包体の製造方法。
- 前記錐体状突起シートを形成するステップの前に、前記錐体状突起成形用シートにおいて前記支持体が粘着される部分に剥離強度を低減するための処理を施すステップをさらに備える、請求項10に記載の錐体状突起シートの梱包体の製造方法。
- 前記剥離強度を低減するための処理とは、離型剤を塗布する及び離型効果を有する材料を用いることの一方又は両方である、請求項11に記載の錐体状突起シートの梱包体の製造方法。
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PCT/JP2015/059049 WO2015147030A1 (ja) | 2014-03-26 | 2015-03-25 | 錐体状突起シートの梱包体及びその製造方法 |
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US (1) | US20170101242A1 (ja) |
EP (1) | EP3108924A4 (ja) |
JP (1) | JP5851077B1 (ja) |
KR (1) | KR20160138152A (ja) |
CN (1) | CN106456952A (ja) |
TW (1) | TW201600130A (ja) |
WO (1) | WO2015147030A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3342447A4 (en) * | 2016-02-11 | 2018-09-26 | Nissha Co., Ltd. | Storage sheet and microneedle sheet packaging body |
WO2018220926A1 (ja) * | 2017-05-30 | 2018-12-06 | Nissha株式会社 | マイクロニードルパッチとその梱包体 |
JP2020142415A (ja) * | 2019-03-05 | 2020-09-10 | 富士フイルム株式会社 | 凹段差部に凹状パターンを有するモールドの作製方法及びパターンシートの製造方法 |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020099513A (ja) * | 2018-12-21 | 2020-07-02 | ロレアル | マイクロニードルシートを使用するキット及び美容方法 |
WO2020180033A1 (ko) * | 2019-03-04 | 2020-09-10 | 주식회사 대웅테라퓨틱스 | 마이크로니들 어레이 및 이의 제조방법 |
KR20220065655A (ko) * | 2020-11-13 | 2022-05-20 | 주식회사 대웅테라퓨틱스 | 마이크로니들 어레이 및 이의 제조방법 |
KR102425556B1 (ko) * | 2021-12-07 | 2022-07-29 | 주식회사 대웅테라퓨틱스 | 마이크로니들 조립체 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010530327A (ja) * | 2007-06-20 | 2010-09-09 | スリーエム イノベイティブ プロパティズ カンパニー | ウェブ上への超音波射出成形 |
WO2011002034A1 (ja) * | 2009-07-01 | 2011-01-06 | 凸版印刷株式会社 | 針状体 |
JP2013013558A (ja) * | 2011-07-04 | 2013-01-24 | Fujifilm Corp | マイクロニードルパッチ収納ケース |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6908453B2 (en) * | 2002-01-15 | 2005-06-21 | 3M Innovative Properties Company | Microneedle devices and methods of manufacture |
EP2286980A4 (en) * | 2008-06-05 | 2011-07-13 | Asahi Glass Co Ltd | NANO-PRINTING MOLD, METHOD FOR MANUFACTURING THE SAME, AND PROCESSES FOR PRODUCING A MOLDED RESIN HAVING A FINE ROUGH STRUCTURE ON A SURFACE AND FOR PRODUCING A METAL GRID POLARIZER |
JP2010094414A (ja) * | 2008-10-20 | 2010-04-30 | Kyokko Seiko Co Ltd | マイクロニードルシート貼付剤とその製造方法および製造装置 |
AU2009329806A1 (en) * | 2008-12-22 | 2010-07-01 | The University Of Queensland | Patch production |
JP5423522B2 (ja) * | 2010-03-25 | 2014-02-19 | 日本電気株式会社 | モジュール及びモジュール製造方法 |
JP5622792B2 (ja) * | 2012-05-29 | 2014-11-12 | 池田機械産業株式会社 | マイクロニードルパッチの製造装置 |
-
2015
- 2015-03-25 JP JP2015548529A patent/JP5851077B1/ja active Active
- 2015-03-25 TW TW104109523A patent/TW201600130A/zh unknown
- 2015-03-25 EP EP15767856.6A patent/EP3108924A4/en not_active Withdrawn
- 2015-03-25 CN CN201580015749.6A patent/CN106456952A/zh active Pending
- 2015-03-25 WO PCT/JP2015/059049 patent/WO2015147030A1/ja active Application Filing
- 2015-03-25 KR KR1020167029098A patent/KR20160138152A/ko unknown
- 2015-03-25 US US15/128,876 patent/US20170101242A1/en not_active Abandoned
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010530327A (ja) * | 2007-06-20 | 2010-09-09 | スリーエム イノベイティブ プロパティズ カンパニー | ウェブ上への超音波射出成形 |
WO2011002034A1 (ja) * | 2009-07-01 | 2011-01-06 | 凸版印刷株式会社 | 針状体 |
JP2013013558A (ja) * | 2011-07-04 | 2013-01-24 | Fujifilm Corp | マイクロニードルパッチ収納ケース |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3342447A4 (en) * | 2016-02-11 | 2018-09-26 | Nissha Co., Ltd. | Storage sheet and microneedle sheet packaging body |
KR20180109663A (ko) * | 2016-02-11 | 2018-10-08 | 닛샤 가부시키가이샤 | 수납 시트 및 마이크로니들 시트의 곤포체 |
KR102665117B1 (ko) | 2016-02-11 | 2024-05-13 | 닛샤 가부시키가이샤 | 수납 시트 및 마이크로니들 시트의 곤포체 |
WO2018220926A1 (ja) * | 2017-05-30 | 2018-12-06 | Nissha株式会社 | マイクロニードルパッチとその梱包体 |
JPWO2018220926A1 (ja) * | 2017-05-30 | 2019-06-27 | Nissha株式会社 | マイクロニードルパッチとその梱包体 |
TWI798229B (zh) * | 2017-05-30 | 2023-04-11 | 日商日寫股份有限公司 | 微針貼片及其包裝體 |
JP2020142415A (ja) * | 2019-03-05 | 2020-09-10 | 富士フイルム株式会社 | 凹段差部に凹状パターンを有するモールドの作製方法及びパターンシートの製造方法 |
JP7038679B2 (ja) | 2019-03-05 | 2022-03-18 | 富士フイルム株式会社 | 熱可塑性樹脂原版の作製方法、金型の作製方法、モールドの作製方法及びパターンシートの製造方法 |
US11534943B2 (en) | 2019-03-05 | 2022-12-27 | Fujifilm Corporation | Production method of mold having recessed pattern in recessed step portion, and manufacturing method of pattern sheet |
US11772305B2 (en) | 2019-03-05 | 2023-10-03 | Fujifilm Corporation | Production method of mold having recessed pattern in recessed step portion |
Also Published As
Publication number | Publication date |
---|---|
JPWO2015147030A1 (ja) | 2017-04-13 |
US20170101242A1 (en) | 2017-04-13 |
CN106456952A (zh) | 2017-02-22 |
EP3108924A1 (en) | 2016-12-28 |
KR20160138152A (ko) | 2016-12-02 |
JP5851077B1 (ja) | 2016-02-03 |
TW201600130A (zh) | 2016-01-01 |
EP3108924A4 (en) | 2017-03-22 |
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