WO2015145902A1 - Récipient de fluide médical - Google Patents

Récipient de fluide médical Download PDF

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Publication number
WO2015145902A1
WO2015145902A1 PCT/JP2014/083743 JP2014083743W WO2015145902A1 WO 2015145902 A1 WO2015145902 A1 WO 2015145902A1 JP 2014083743 W JP2014083743 W JP 2014083743W WO 2015145902 A1 WO2015145902 A1 WO 2015145902A1
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WO
WIPO (PCT)
Prior art keywords
mouth
outer frame
plug
rubber plug
rubber
Prior art date
Application number
PCT/JP2014/083743
Other languages
English (en)
Japanese (ja)
Inventor
立石　勇
慎司 馬場
Original Assignee
株式会社大塚製薬工場
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社大塚製薬工場 filed Critical 株式会社大塚製薬工場
Priority to CN201480077427.XA priority Critical patent/CN106170278A/zh
Priority to SG11201606797PA priority patent/SG11201606797PA/en
Publication of WO2015145902A1 publication Critical patent/WO2015145902A1/fr
Priority to PH12016501859A priority patent/PH12016501859A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/05—Containers specially adapted for medical or pharmaceutical purposes for collecting, storing or administering blood, plasma or medical fluids ; Infusion or perfusion containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D17/00—Rigid or semi-rigid containers specially constructed to be opened by cutting or piercing, or by tearing of frangible members or portions
    • B65D17/28—Rigid or semi-rigid containers specially constructed to be opened by cutting or piercing, or by tearing of frangible members or portions at lines or points of weakness
    • B65D17/401—Rigid or semi-rigid containers specially constructed to be opened by cutting or piercing, or by tearing of frangible members or portions at lines or points of weakness characterised by having the line of weakness provided in an end wall
    • B65D17/4011—Rigid or semi-rigid containers specially constructed to be opened by cutting or piercing, or by tearing of frangible members or portions at lines or points of weakness characterised by having the line of weakness provided in an end wall for opening completely by means of a tearing tab
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1406—Septums, pierceable membranes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1412—Containers with closing means, e.g. caps
    • A61J1/1431—Permanent type, e.g. welded or glued
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/1462—Containers with provisions for hanging, e.g. integral adaptations of the container
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D1/00—Containers having bodies formed in one piece, e.g. by casting metallic material, by moulding plastics, by blowing vitreous material, by throwing ceramic material, by moulding pulped fibrous material, by deep-drawing operations performed on sheet material
    • B65D1/02—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents
    • B65D1/0223—Bottles or similar containers with necks or like restricted apertures, designed for pouring contents characterised by shape
    • B65D1/023—Neck construction
    • B65D1/0238—Integral frangible closures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D23/00—Details of bottles or jars not otherwise provided for
    • B65D23/003—Suspension means
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D41/00—Caps, e.g. crown caps or crown seals, i.e. members having parts arranged for engagement with the external periphery of a neck or wall defining a pouring opening or discharge aperture; Protective cap-like covers for closure members, e.g. decorative covers of metal foil or paper
    • B65D41/32—Caps or cap-like covers with lines of weakness, tearing-strips, tags, or like opening or removal devices, e.g. to facilitate formation of pouring openings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D51/00—Closures not otherwise provided for
    • B65D51/002—Closures to be pierced by an extracting-device for the contents and fixed on the container by separate retaining means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/14—Details; Accessories therefor
    • A61J1/18—Arrangements for indicating condition of container contents, e.g. sterile condition
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00—Details relating to container closures
    • B65D2251/0003—Two or more closures
    • B65D2251/0006—Upper closure
    • B65D2251/0009—Upper closure of the 17-type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00—Details relating to container closures
    • B65D2251/0003—Two or more closures
    • B65D2251/0006—Upper closure
    • B65D2251/0015—Upper closure of the 41-type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00—Details relating to container closures
    • B65D2251/0003—Two or more closures
    • B65D2251/0037—Intermediate closure(s)
    • B65D2251/0059—Intermediate closure(s) of the 51-type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D2251/00—Details relating to container closures
    • B65D2251/0003—Two or more closures
    • B65D2251/0068—Lower closure
    • B65D2251/0093—Membrane
    • B65D2251/0096—Membrane integral with the container

Definitions

  • the present invention relates to a chemical container having a container body molded by a blow fill seal method and a cap attached to the mouth of the container body.
  • a plastic bottle molded by a blow fill seal (BFS) method is known as a container for a chemical solution such as an infusion solution.
  • BFS blow fill seal
  • bottle formation, chemical filling, and bottle closing are performed continuously in a common mold. This method is suitable for mass production of bottles and can reduce costs.
  • JP 50-36290 A European Patent No. 0364783
  • a cap is attached to the mouth of a BFS bottle.
  • the cap is attached by, for example, disposing a rubber stopper on the top surface of the bottle, covering the rubber stopper and the mouth of the bottle with an outer frame material, and then welding the outer frame material and the bottle.
  • a rubber stopper (reference numeral 6 of Patent Document 1 and reference numeral 5 of Patent Document 2) has been applied to substantially the entire top surface of the bottle. It is the size to cover. In order to reduce the cost, the rubber plug is required to be downsized.
  • the rubber plugs are generally the same thickness, it is difficult to crimp the peripheral edge of the rubber plug with sufficient strength between the bottle and the outer frame material. This insufficient pressure bonding may cause liquid leakage when the needle is inserted into the rubber stopper.
  • An object of the present invention is to provide a chemical container capable of reducing cost by reducing the size of a rubber stopper and preventing liquid leakage from around the rubber stopper during needle sticking.
  • One embodiment of the present invention covers a container body integrally molded by a blow fill seal method, a rubber stopper disposed on the top of the mouth of the container body, the rubber stopper and the mouth.
  • An outer frame member having a receiving surface with which the mouth abuts, and an outer frame member having a crimping portion crimped in the direction of the bottom of the container body with respect to the mouth, and the rubber plug Is a chemical solution container including a plug body that covers a part of the zenith surface of the mouth part, and a collar part that extends between the crimping part and the mouth part from the lower outer periphery of the stopper body.
  • the portion of the rubber plug that is crimped by the mouth portion and the outer frame material is a collar portion that is relatively thin with respect to the stopper body, and therefore, between the mouth portion and the outer frame material (crimp portion).
  • the collar part of the rubber plug can be crimped with sufficient strength.
  • the rubber stopper can be firmly held by the buttock. Therefore, it is possible to suppress the rubber plug from moving when the needle is inserted into the plug main body, and the movement of the rubber plug from being pressed and greatly bent by the rubber plug. As a result, it is possible to prevent an extra liquid leakage path from being formed in the outer frame member, and thus it is possible to prevent liquid leakage from occurring around the rubber plug.
  • the plug body can be made smaller by reducing the amount of rubber material used in the buttocks, it is possible to at least reduce costs in accordance with the reduction of the amount used.
  • the plug main body of the rubber plug covers a central portion of the zenith surface of the mouth portion, and the collar portion of the rubber plug covers a peripheral portion of the zenith surface of the mouth portion. Moreover, it is formed in an annular shape over the entire circumference of the plug body.
  • the rubber plug is uniformly crimped with sufficient strength over the entire circumference of the peripheral edge. Thereby, liquid leakage can be prevented at any location around the rubber plug.
  • the outer frame member has a protrusion embedded in the upper surface of the plug body of the rubber plug.
  • the protrusion of the outer frame member is formed in an annular shape.
  • downward pressure corresponding to the protrusion amount of the projection of the outer frame material can be formed over the entire circumference of the rubber plug.
  • the plug body of the rubber plug has a protrusion deformed by pressing with the outer frame material.
  • the rubber plug can be pressed downward by the length corresponding to the protruding amount of the protrusion of the plug main body, so that liquid leakage can be prevented more favorably.
  • the outer frame member includes an annular plate portion as the pressure-bonding portion facing the peripheral portion of the zenith surface of the mouth portion across the collar portion of the rubber plug, and the annular plate portion.
  • An upper part that is integrally connected to the inner peripheral part and covers the stopper main body, and a lower part that is integrally connected to the outer peripheral part of the annular plate part and covers the mouth part.
  • the collar portion of the rubber plug extends to reach the inner peripheral surface of the lower portion of the outer frame material.
  • the mouth portion includes a flange portion formed over the entire circumference at a position spaced downward from the top surface, and a lower portion of the outer frame material is welded to the flange portion. Has been.
  • the lower part of the outer frame member includes a collar part formed over the entire circumference, and the collar part of the mouth part is welded to the lower surface of the collar part of the outer frame material. ing.
  • the depth h 2 of the lower part of the outer frame member is smaller than the sum of the height h 1 from the collar part of the mouth part and the thickness T 4 of the collar part of the rubber plug. .
  • the collar portion of the rubber plug can be crimped satisfactorily.
  • the collar portion of the rubber plug has a thickness of 0.2 mm to 3 mm.
  • the outer frame material includes a pull ring for opening an upper portion thereof.
  • FIG. 1 is a schematic perspective view of a chemical bottle according to an embodiment of the present invention.
  • FIG. 2 is a schematic cross-sectional view showing the configuration around the mouth of the chemical bottle of FIG.
  • FIG. 3 is a schematic bottom view of the outer frame member.
  • FIG. 4 is a diagram illustrating a part of the process of attaching the cap to the mouth.
  • FIG. 5 is a diagram showing the next step of FIG.
  • FIG. 6 is a diagram showing a step subsequent to FIG. 7A and 7B are diagrams showing a usage state of the chemical liquid bottle of FIG. 1, in which FIG. 7A shows a state when a needle is inserted into a rubber stopper, and FIG. 7B shows a state where the chemical liquid bottle is turned upside down. ing.
  • FIG. 8B are diagrams showing the usage state of the chemical bottle according to the reference example, FIG. 8A shows the state when the needle is inserted into the rubber stopper, and FIG. 8B shows the state where the chemical bottle is turned upside down. Show.
  • FIG. 9A and FIG. 9B are views showing modifications of the rubber plug, FIG. 9A shows a state before the cap is attached, and FIG. 9B shows a state after the cap is attached.
  • FIG. 10 is a diagram illustrating a modified example of the cap.
  • FIG. 1 is a schematic perspective view of a chemical bottle 1 according to an embodiment of the present invention.
  • FIG. 2 is a schematic cross-sectional view showing a configuration around the mouth portion 5 of the chemical liquid bottle 1 of FIG.
  • FIG. 3 is a schematic bottom view of the outer frame member 13.
  • the chemical bottle 1 as an example of the chemical container of the present invention includes a plastic bottle body 2 and an cap 3 as an example of the container body of the present invention.
  • the plastic bottle main body 2 integrally includes a body portion 4 in which a chemical solution is accommodated and a mouth portion 5 disposed on the top portion.
  • the cap 3 is attached to the mouth portion 5.
  • the plastic bottle main body 2 integrally having the barrel portion 4 and the mouth portion 5 can be produced by a blow fill seal (BFS) method.
  • BFS blow fill seal
  • a parison is produced by extruding the material of the plastic bottle body 2.
  • the material used is not particularly limited as long as it is plastic.
  • polyolefin resins such as polyethylene, polypropylene, poly (4-methylpentene), polytetrafluoroethylene, and polycyclic compounds such as ethylene-tetracyclododecene.
  • examples include olefin resins, and preferably polypropylene and polycyclic olefin resins.
  • Polyolefin resins such as polyethylene and polypropylene are generally low in elution for various chemical solutions and are general-purpose plastics. Therefore, elution of impurities into the chemical solution can be suppressed, and the cost of the plastic bottle body 2 can be reduced.
  • the materials used can be used alone or in combination of two or more.
  • the plastic bottle main body 2 may be formed in a single layer structure, or may be formed in a multilayer structure in which a plurality of resins are laminated.
  • the obtained parison is sandwiched between split molds to form the body 4 (blow process), and the inside of the body 4 is filled with a chemical (filling process).
  • the plastic bottle body 2 containing the chemical solution is obtained by forming the mouth part 5 between the split molds and sealing the open end of the mouth part 5 (sealing process).
  • the parts of the plastic bottle body 2 will be described more specifically.
  • the barrel 4 is formed in an elliptical bottle shape with a tapered upper part.
  • a scale 6 for indicating the amount of the chemical solution is provided on the outer peripheral surface of the body portion 4 along the depth direction of the plastic bottle main body 2.
  • a hanger 7 for hooking and using the chemical liquid bottle 1 is formed at the bottom of the body 4.
  • the hanger 7 is formed in, for example, a fin shape that protrudes from the flat bottom portion of the trunk portion 4.
  • the mouth part 5 is integrally connected to the body part 4 via the neck part 8 of the plastic bottle body 2.
  • the mouth portion 5 includes a substantially cylindrical tube portion 9 and an annular plate-shaped flange portion 10 (a flange portion) formed on the entire outer periphery of the lower portion of the tube portion 9.
  • the open end of the cylindrical portion 9 is closed by the top thin film 11 formed by the sealing process.
  • the top thin film 11 forms the top surface of the plastic bottle body 2.
  • the top thin film 11 is a portion that is formed thinner than the cylindrical portion 9 and the flange portion 10 and has flexibility. For example, as shown in FIG. 2, the thicknesses T 1 and T 2 of the cylindrical portion 9 and the bringe portion 10 are about 1.0 mm to 2.0 mm, whereas the thickness T 3 of the top thin film 11 is 0. About 3 mm to 0.6 mm. This thickness difference is caused by the plastic bottle body 2 being produced by the blow fill sealing method.
  • the cap 3 includes a rubber plug 12 and an outer frame member 13.
  • the rubber plug 12 is formed in a hat shape integrally including a cylindrical plug body 14 and an annular plate-like flange portion 15 formed over the entire circumference of the lower outer periphery of the plug body 14.
  • Concave portions 16 and 17 are formed in the center portions of the upper surface and the lower surface of the plug body 14, respectively.
  • the recess 16 and the recess 17 face each other, and the plug body 14 is selectively thinned at this position. By inserting a needle into the recess 16, a through hole can be easily formed in the rubber stopper 12.
  • the size of the plug body 14 is, for example, a height H 1 of 3 mm to 7 mm and a diameter D 1 of 15 mm to 25 mm.
  • the shape of the plug body 14 may be defined as a disk shape.
  • the size of the flange portion 15, for example, the thickness T 4 is the 0.2 mm ⁇ 3 mm, diameter D 2 is 25 mm ⁇ 40 mm.
  • extending the width W 1 of the flange portion 15 is, for example, 5 mm ⁇ 15 mm.
  • the material of the rubber plug 12 includes, for example, synthetic rubber such as butyl rubber and isoprene rubber, and thermoplastic elastomer such as olefin elastomer and styrene elastomer.
  • synthetic rubber such as butyl rubber and isoprene rubber
  • thermoplastic elastomer such as olefin elastomer and styrene elastomer.
  • thermoplastic elastomer such as olefin elastomer and styrene elastomer.
  • the outer frame member 13 includes a cylindrical mouth accommodating portion 18 (lower portion), a cylindrical rubber stopper accommodating portion 19 (upper portion) having a smaller diameter than the mouth portion accommodating portion 18, and the mouth accommodating portion 18.
  • An annular plate-shaped step portion 20 (crimping portion) that connects the upper end and the lower end of the rubber plug housing portion 19 is integrally included. That is, the outer frame member 13 has a two-stage structure in which the rubber stopper housing part 19 is placed on the mouth part housing part 18 via the step part 20.
  • An annular plate-like flange portion 21 is integrally formed on the outer periphery of the lower portion of the mouth portion accommodating portion 18 over the entire circumference.
  • a protrusion 22 is formed on the upper wall of the rubber plug housing portion 19 so as to protrude downward in the axial direction of the rubber plug housing portion 19.
  • the protrusion 22 is formed in a ring shape having a thickness of about 0.5 mm to 2 mm and a height of about 1 mm to 3 mm, for example.
  • the inner region surrounded by the protrusion 22 on the upper wall of the rubber stopper housing portion 19 is a detachable pull ring 23.
  • the pull ring 23 By pulling and removing the pull ring 23, the user can open the outer frame member 13 and expose the upper surface of the rubber stopper 12.
  • the stepped portion 20 has an inner periphery of the mouth accommodating portion 18 and an outer periphery of the rubber stopper accommodating portion 19 so that a horizontal plane perpendicular to the axial direction of the mouth accommodating portion 18 and the rubber stopper accommodating portion 19 appears. Each is connected vertically.
  • thermoplastic resin preferably polyethylene, polypropylene and the like.
  • FIG. 4 to FIG. 6 are diagrams showing the process of attaching the cap 3 to the mouth part 5 in order.
  • the cap 3 is assembled by fitting the plug body 14 of the rubber plug 12 into the rubber plug housing portion 19 of the outer frame member 13.
  • the diameter of the rubber plug 12 (diameter D 2 of the flange portion 15) may be substantially the same as the inner diameter D 3 of the mouth portion accommodating portion 18. That is, in the assembled cap 3, the outer periphery of the flange portion 15 of the rubber plug 12 may reach the inner peripheral surface of the mouth portion accommodating portion 18. With this configuration, since the pressure-bonding area of the flange portion 15 of the rubber plug 12 can be increased, the degree of pressure-bonding of the rubber plug 12 can be improved. Further, in this state, the protrusion 22 of the rubber plug housing portion 19 may not be reduced on the upper surface of the plug body 14.
  • the cap 3 is put on the mouth part 5 of the plastic bottle body 2.
  • the plastic bottle body 2 is pushed in until the flange portion 21 (the flange portion) of the outer frame member 13 comes into contact with the flange portion 10 of the mouth portion 5.
  • the mouth portion 5 and the outer frame member 13 are fixed by friction between the protrusion 31 provided on the cylindrical portion 9 and the inner peripheral surface of the mouth portion accommodating portion 18, and the lower surface of the flange portion 21 of the outer frame member 13 It is preferable to weld and fix the flange portion 10 of the mouth portion 5 in contact therewith.
  • known methods such as heat sealing, ultrasonic welding, and high frequency welding can be employed.
  • the depth h 2 needs to be slightly smaller than the height h 1 plus the thickness T 4 of the flange portion 15 of the rubber plug 12.
  • the top thin film 11 of the mouth portion 5 is covered with the plug main body 14 of the rubber plug 12 at the center and with the flange portion 15 of the rubber plug 12 at the peripheral edge.
  • the stepped portion 20 is formed horizontally with respect to the axial direction of the mouth portion accommodating portion 18 and the rubber plug accommodating portion 19, the outer frame member 13 has a clear two-stage structure. By pressing the step portion 20, a force along the axial direction can be easily applied, so that workability when the flange portion 15 is crimped can be improved.
  • the rubber stopper 12 is pushed by pushing the plastic bottle body 2.
  • the protrusion 22 of the rubber plug housing portion 19 is reduced to the peripheral edge portion of the upper surface of the plug body 14 and is embedded in the upper surface.
  • the mouth portion 5 and the outer frame member 13 are welded.
  • the flange portion 10 of the mouth portion 5 and the lower surface of the flange portion 21 of the outer frame member 13 are welded.
  • the cap 3 is completely attached through the above steps.
  • FIGS. 8A and 8B are diagrams showing the usage state of the chemical liquid bottle 1 of FIG. 1, in which FIG. 7A shows a state when the needle 24 is inserted into the rubber stopper 12, and FIG. 7B shows the chemical liquid bottle 1 upside down. Shows the state. 8A and 8B are diagrams showing the usage state of the chemical liquid bottle 25 according to the reference example.
  • FIG. 8A shows the state when the needle 24 is inserted into the rubber stopper 12, and
  • FIG. 8B shows the chemical liquid bottle 25 upside down. It shows the state. 7A and 7B, and FIGS. 8A and 8B both show a state in which the pull ring 23 is removed and an opening 26 is formed in the outer frame member 13.
  • 8A and 8B, parts corresponding to those shown in FIGS. 7A and 7B are denoted by the same reference numerals.
  • the difference between the chemical solution bottle 1 and the chemical solution bottle 25 is that the chemical solution bottle 25 does not include the step portion 20 of the outer frame member 13, and the rubber stopper accommodating portion 19 has a diameter substantially the same as the mouth portion accommodating portion 18 (slightly It is a point formed with a small diameter.
  • the chemical bottle 25 is not provided with the flange portion 15 of the rubber plug 12.
  • the chemical bottle 25, the rubber plug 12 of substantially the same diameter D 4 and the diameter D 2 of the flange portion 15 of the rubber plug 12 of the bottles 1 (the plug body 14) is formed in a uniform thickness.
  • the cylindrical portion 9 is in direct contact with the rubber stopper housing portion 19.
  • the rubber stopper 12 of the chemical solution bottle 25 is pressure-bonded between the mouth portion 5 and the outer frame member 13, the rubber stopper housing of the top thin film 11 of the mouth portion 5 and the outer frame member 13 is accommodated. It can be said that it is accommodated in a space partitioned by the portion 19.
  • the portion of the rubber plug 12 that is pressure-bonded by the mouth portion 5 and the outer frame member 13 is a flange portion 15 that is relatively thin with respect to the plug main body 14. Therefore, the flange portion 15 of the rubber plug 12 can be pressure-bonded with sufficient strength between the tubular portion 9 and the top thin film 11 of the mouth portion 5 and the step portion 20 of the outer frame member 13. As a result, the rubber stopper 12 can be firmly held by the flange portion 15.
  • the rubber plug 12 is pressurized corresponding to the protruding amount of the protrusion 22 by embedding the protrusion 22 of the outer frame member 13. Thereby, the leaked liquid is also shut off, and as a result, the liquid leakage can be effectively prevented.
  • the amount of rubber material used in the upper part of the flange portion 15 can be reduced and the plug body 14 can be downsized, so at least cost reduction corresponding to the reduction in the amount of use can be achieved. Can do.
  • the chemical bottle 1 reduces the cost by reducing the size of the rubber plug 12 and leaks from the periphery of the rubber plug 12 during needle sticking. It can be seen that this can be prevented.
  • the outer peripheral edge of the flange portion 15 of the rubber plug 12 may not reach the inner peripheral surface of the mouth portion accommodating portion 18.
  • the blocking of the liquid on the upper surface of the plug body 14 can be formed by a protrusion 30 formed on the upper surface of the plug body 14 as shown in FIG. 9A.
  • the protrusion 30 may be crushed and deformed by the outer frame member 13 in a state after the cap 3 is attached.
  • the protrusions 22 and 30 may be omitted.
  • the step part 20 which connects the opening
  • the shape of the plastic bottle main body 2 various bottle shapes such as a perfect circle bottle shape and a square bottle shape can be adopted in addition to the above-mentioned elliptical bottle shape.
  • a protective film or the like can be employed in addition to the pull ring 23 described above.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ceramic Engineering (AREA)
  • Hematology (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Closures For Containers (AREA)
  • Containers Having Bodies Formed In One Piece (AREA)

Abstract

La présente invention concerne un récipient de fluide médical comprenant : un corps de récipient moulé d'un seul tenant en faisant appel à un procédé de soufflage-remplissage-scellage ; un bouchon en caoutchouc disposé sur un plan zénithal par rapport à une embouchure du corps de récipient ; et un cadre externe à positionner sur le bouchon en caoutchouc et l'embouchure, le cadre externe ayant une face de réception sur laquelle vient en butée l'embouchure et ayant une partie sertie qui est sertie vers la partie inférieure du corps de récipient par rapport à l'embouchure. Le bouchon en caoutchouc comprend : un corps de bouchon qui recouvre une partie du plan zénithal de l'embouchure ; et une partie bride qui s'étend entre la partie sertie et l'embouchure à partir d'une circonférence inférieure du corps de bouchon.
PCT/JP2014/083743 2014-03-25 2014-12-19 Récipient de fluide médical WO2015145902A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
CN201480077427.XA CN106170278A (zh) 2014-03-25 2014-12-19 药液容器
SG11201606797PA SG11201606797PA (en) 2014-03-25 2014-12-19 Medical fluid container
PH12016501859A PH12016501859A1 (en) 2014-03-25 2016-09-22 Medical fluid container

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014062486A JP5832042B2 (ja) 2014-03-25 2014-03-25 薬液容器
JP2014-062486 2014-03-25

Publications (1)

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WO2015145902A1 true WO2015145902A1 (fr) 2015-10-01

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JP (1) JP5832042B2 (fr)
CN (1) CN106170278A (fr)
PH (1) PH12016501859A1 (fr)
SG (1) SG11201606797PA (fr)
TW (1) TWI556816B (fr)
WO (1) WO2015145902A1 (fr)

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CN107789689A (zh) * 2016-08-30 2018-03-13 B·布莱恩·阿维图姆股份公司 用于筒状容器的端盖
US11607369B2 (en) 2017-11-17 2023-03-21 Koska Family Limited Systems and methods for fluid delivery manifolds
USD992110S1 (en) 2021-08-10 2023-07-11 Koska Family Limited Sealed fluid container

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JP7016315B2 (ja) * 2016-06-02 2022-02-04 大塚テクノ株式会社 キャップ
DE102016009594A1 (de) * 2016-08-06 2018-02-08 Kocher-Plastik Maschinenbau Gmbh Verfahren zum Herstellen eines Verschlusses bei einem aus Kunststoff hergestellten Behälter
WO2022202257A1 (fr) * 2021-03-24 2022-09-29 テルモ株式会社 Dispositif d'administration de médicament liquide

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CN107789689A (zh) * 2016-08-30 2018-03-13 B·布莱恩·阿维图姆股份公司 用于筒状容器的端盖
EP3292855A1 (fr) * 2016-08-30 2018-03-14 B. Braun Avitum AG Capuchon de fermeture pour un contenant en forme de cartouche
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CN107789689B (zh) * 2016-08-30 2021-08-27 B·布莱恩·阿维图姆股份公司 用于筒状容器的端盖
US11607369B2 (en) 2017-11-17 2023-03-21 Koska Family Limited Systems and methods for fluid delivery manifolds
USD992110S1 (en) 2021-08-10 2023-07-11 Koska Family Limited Sealed fluid container

Also Published As

Publication number Publication date
PH12016501859B1 (en) 2016-12-19
SG11201606797PA (en) 2016-09-29
JP2015181821A (ja) 2015-10-22
JP5832042B2 (ja) 2015-12-16
CN106170278A (zh) 2016-11-30
TW201540293A (zh) 2015-11-01
PH12016501859A1 (en) 2016-12-19
TWI556816B (zh) 2016-11-11

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