WO2015078397A1 - Herbes médicinales chinoises destinées à réparer les lésions causées par les ultraviolets et à favoriser le métabolisme énergétique, et utilisations de ces herbes dans des produits cosmétiques - Google Patents

Herbes médicinales chinoises destinées à réparer les lésions causées par les ultraviolets et à favoriser le métabolisme énergétique, et utilisations de ces herbes dans des produits cosmétiques Download PDF

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Publication number
WO2015078397A1
WO2015078397A1 PCT/CN2014/092433 CN2014092433W WO2015078397A1 WO 2015078397 A1 WO2015078397 A1 WO 2015078397A1 CN 2014092433 W CN2014092433 W CN 2014092433W WO 2015078397 A1 WO2015078397 A1 WO 2015078397A1
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WIPO (PCT)
Prior art keywords
leaf extract
energy metabolism
weight
cosmetics
eucalyptus leaf
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PCT/CN2014/092433
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English (en)
Chinese (zh)
Inventor
孙懿
祝乐
赵亚
陈默
熊卫国
吕洛
方程
Original Assignee
上海家化联合股份有限公司
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Publication of WO2015078397A1 publication Critical patent/WO2015078397A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations

Definitions

  • the invention relates to a Chinese herbal medicine having ultraviolet damage repairing and promoting energy metabolism and its application in cosmetics, in particular to a lotus leaf extract and its application in cosmetics.
  • Ultraviolet rays not only damage the outermost skin cells, but also cause dermal cell necrosis and metabolic disorders.
  • the impurities in the cells cannot be metabolized, causing sunburn, loss of elasticity, premature aging, sensitivity, wrinkles, and skin.
  • the tingling and itching are unbearable, scratching the bleeding, the skin's own resistance to disease and resistance is weakened, and even edema, exudation, formation of folliculitis, sputum and other difficult to cure skin diseases.
  • the understanding of the mechanism of ultraviolet light on skin damage includes oxidative stress, inflammatory reaction, apoptosis, degradation of collagen and elastin.
  • the skin tissue cells will produce oxidative stress, produce excessive reactive oxygen species ROS, destroy the integrity of the cell membrane and the anti-oxidation system inside the cell, further causing cell inflammation, apoptosis and tumor formation.
  • ROS reactive oxygen species
  • excessive ultraviolet radiation causes skin collagen, hyaluronic acid and elastin to degrade, resulting in elastic degeneration, roughness and wrinkles. Therefore, most of the repair methods after the ultraviolet ray damage are based on these mechanisms, and substances having antioxidation, anti-inflammatory, and matrix metalloproteinase inhibition activities are used.
  • ash tree extract effectively removes a large number of free radicals generated in human Fb cells after UVB irradiation, and reduces the expression of MMP-1 mRNA and protein, thereby resisting skin damage after UVB irradiation; for example, marigold flower extract contains ⁇ Carotene, which inhibits the production of wrinkles by inhibiting the activity of hyaluronidase, elastase, and MMP-1, thereby exerting an ultraviolet protection effect.
  • ATP is a key molecule in the metabolism of cell energy. It is the main energy source that skin cells can directly use. It is also an important indicator of the healthy viability of cells. The reduction of ATP leads to the reduction of energy metabolism, and the corresponding functional decline. The most obvious is skin aging, dull acne and so on. New research has found that intense exposure to ultraviolet light can cause a decrease in ATP production. Lead to the weakening of energy metabolism, affecting the normal function of skin cells. Therefore, ATP promotes the increase of cells after injury, which can promote the energy metabolism of cells, thereby facilitating the repair of skin damage caused by ultraviolet radiation.
  • loquat leaves are the leaves of the Rosaceae plant Eriobotrya japonica (Thunb.) Lindl. Often used to clear the lungs and cough, reduce the vomiting. It can treat dry mouth and thirst, lung wind sores and acne. Modern pharmacological studies have confirmed that it has good anti-inflammatory, antibacterial and antitussive effects, and is often used to treat acne and de-acne cosmetics.
  • UV protective agents At present, flavonoids, terpenoids, tannins and coumarins are mainly studied. However, there are no reports in the literature that promote the metabolism of energy and the synthesis of ATP can also repair UVB.
  • Patent document 201110250949.3 discloses a Chinese medicine composition for treating cough foot bath. Specifically, the document discloses a foot bath traditional Chinese medicine composition for treating cold, including asarum, cassia twig, clove, myrrh, medlar, golden buckwheat, plantain, sage, mulberry, cat vine, scorpion, Huang Jing, Schizonepeta, Atractylodes, Ephedra, Cinnamon, and Astragalus. It has the function of passing through the active, effectively promoting metabolism, increasing blood circulation, enhancing the basic constitution of the human body, and effectively treating the cold.
  • this patent is a composition and there is no evidence that the single-flavored medicinal material has an energy metabolism effect.
  • Patent document 200810048647.6 discloses a cosmeceutical having anti-allergic function for treating acne and its scar.
  • the document relates to a cosmeceutical having anti-allergic function for treating acne and scars.
  • Its composition consists of honeysuckle, onion, medlar, hundred, centella, salvia, and VC.
  • the preparation method includes several steps of cooking, concentration of the liquid, preparation of the preparation, and the like.
  • This patent application is an anti-allergic effect of the eucalyptus group in medicinal cosmetics, and includes its preparation method, and does not mention energy metabolism.
  • the prior art does not mention the role of eucalyptus leaves in repairing UVB radiation damage and promoting energy metabolism.
  • the present invention finds for the first time the properties of the eucalyptus leaf extract having ultraviolet damage repair and promoting skin cell energy metabolism.
  • the object of the present invention is to provide a Chinese herbal medicine extract having ultraviolet damage repair and promoting cell energy metabolism, which can promote ATP synthesis and repair ultraviolet damage caused by UVB. At the same time, it can be added as an efficacy additive to cosmetics for UV damage repair and skin cell energy supplementation.
  • the eucalyptus medicinal materials are pulverized, soaked in a suitable solvent for about 0.5-1h, extracted by the corresponding method, filtered, and the filtrate is concentrated to about 1 times (V/W) of the total amount of the medicinal material to prepare a crude drug containing 0.5-2 g/ml.
  • the solution is concentrated.
  • the Chinese herbal medicines in the formula may be appropriately enlarged or reduced according to the proportion; suitable solvents include water (distilled water, deionized water, purified water), different concentrations of ethanol solution, different concentrations of polyol solution and other solvents of similar polarity; the extraction method may It is a method of boiling, reflux extraction, dipping, seepage, and the like.
  • the preparation of the eucalyptus leaf extract can also be carried out by supercritical extraction, subcritical extraction, and organic solvent extraction.
  • the solvent for organic solvent extraction includes medium and low polarity solvents such as n-hexane, ethyl acetate, diethyl ether, petroleum ether, acetone, and the like, and different concentrations of ethanol, methanol, and polyol.
  • the extraction method may be a method such as reflux extraction, impregnation, or osmosis.
  • ultrasonic or microwave methods can also be used for assisting during the extraction process.
  • the invention relates to the use of a eucalyptus leaf extract for the repair of ultraviolet damage and the promotion of energy metabolism.
  • the present invention relates to the use of a eucalyptus leaf extract as an additive having ultraviolet damage repair and promoting energy metabolism in cosmetics.
  • the loquat leaf extract is used in an amount from 0.00001 to 100% by weight. In another embodiment, the loquat leaf extract is used in an amount of from 0.0001 to 50% by weight. In a preferred embodiment, the eucalyptus leaf extract is used in an amount of from 0.001% to 20% by weight.
  • the cosmetic of the present invention is selected from the group consisting of: facial cleansers, lotions, lotions, creams, gels, masks.
  • the cosmetic of the present invention comprises a eucalyptus leaf extract and an acceptable adjuvant.
  • the cosmetic comprises from 0.00001 to 100% by weight of eucalyptus leaf extract. In another embodiment, the cosmetic comprises 0.0001-50% by weight of eucalyptus leaf extract. In another In an embodiment, the cosmetic comprises from 0.001% to 20% by weight of the eucalyptus leaf extract.
  • Figure 1 shows the percentage of ATP content of normal cells, UV irradiated cells, and various concentrations of the leaves extract of the present invention.
  • # indicates a significant difference in the UVB irradiation group with respect to the normal group; * indicates a significant difference (p ⁇ 0.05) with respect to the UVB irradiation group.
  • the present invention firstly proposes that the loquat leaves have the effects of ultraviolet damage repair and energy metabolism.
  • the eucalyptus leaf extract provided by the invention can repair the energy loss of cells after UVB irradiation, promote the energy metabolism of skin cells and the synthesis of ATP, thereby facilitating the repair of ultraviolet damage.
  • the inventors of the present invention found that the eucalyptus leaf extract has ultraviolet damage repair and promotes energy metabolism.
  • the eucalyptus leaf extract can be added to the cosmetic as an efficacy additive.
  • the present invention firstly proposes that the eucalyptus leaf extract has ultraviolet damage repair and promotes energy metabolism, and can be added as a functional additive to cosmetics for ultraviolet damage repair and skin cell energy supplementation.
  • the loquat leaf extract can be in a variety of forms.
  • the application form of the eucalyptus leaf extract may be a cleansing lotion, a lotion, an emulsion, a cream, a gel, a mask, or the like, which can be applied to human skin.
  • ingredients other than the eucalyptus leaf extract may be any ingredients required for a cosmetic formulation, such as: water, ethanol, butylene glycol, propylene glycol, oils, emulsifiers, thickeners, preservatives, etc.; Function, such as: adding sunscreen ingredients to promote energy metabolism sunscreen cosmetics, adding oil control ingredients to promote energy metabolism oil control cosmetics, adding moisturizing ingredients to promote energy metabolism moisturizing cosmetics, adding whitening ingredients to promote energy metabolism whitening Cosmetics, adding anti-aging ingredients to promote energy metabolism anti-aging cosmetics and so on.
  • the eucalyptus leaf extract can be used at a concentration of from 0.00001 to 100% by weight.
  • the eucalyptus leaf extract may be used at a concentration of 0.0001 to 50% by weight.
  • the eucalyptus leaf extract is used at a concentration of from 0.00001 to 100% by weight.
  • the concentration of the eucalyptus leaf extract is between 0.001 and 50% by weight.
  • the eucalyptus leaf extract is used at a concentration of from 0.001% to 20% by weight.
  • the loquat leaf extract can be added to various cosmetics in a ratio of 0.00001 to 100% by weight.
  • the eucalyptus leaf extract may be used in an amount of 0.00001 to 25% by weight, such as 0.0001 to 50% by weight, such as 0.001 to 75% by weight, for example 0.1 to 100% by weight.
  • the amount of the eucalyptus leaf extract in the cosmetic is from 0.0001 to 50% by weight.
  • the eucalyptus leaf extract is used in the cosmetic in an amount of from 0.001% to 20% by weight.
  • Example 1 Repair of skin cell energy damage caused by sputum leaves against UVB irradiation
  • 0.1 g of the eucalyptus leaf extract was accurately weighed and dissolved in 10 ml of deionized water to obtain a 10 mg/ml eucalyptus leaf extract, which was diluted to 10 ug/ml and 1 ug/ml with PBS buffer to obtain a sample solution.
  • the adjusted concentration is inoculated into the cell plate.
  • the cells were placed under a UVB irradiation apparatus, and normal medium and medium containing the extract of the example were added to continue the culture incubation.
  • test solution in the kit After incubation for a period of time, add the test solution in the kit to each well, shake, and stabilize the fluorescence at room temperature. The instrument will detect the reading.
  • the fluorescence unit RLU measured in each well was recorded, and the average of 3 replicate wells in each group was averaged.
  • the experimental results were subjected to t test, P ⁇ 0.05, indicating significant difference; p ⁇ 0.01 indicates that the difference was very significant.
  • the percentage value of ATP content of each unit of fluorescence was calculated based on 100% of normal cells.
  • the extract of loquat leaf had UV damage repair and promoted cell energy metabolism. Even at low concentrations (for example, 10 ug/ml), the extract of Loquat Leaf has a good repair effect on the energy loss of cells after UVB UV irradiation, promotes the synthesis of ATP, and maintains the energy metabolism level of skin cells. As shown in Table 1 and Figure 1, a repair rate of nearly 20% can be achieved at a low dose concentration of 10 ug/ml.
  • An energy metabolism anti-aging cream comprising the loquat leaf extract of the present invention was prepared according to the ingredients and amounts of Table 2.
  • the preparation method comprises the following steps: dissolving the eucalyptus leaf extract with 1,3-butanediol, adding it to water, and stirring uniformly to obtain an aqueous phase.
  • the alcohol, caprylic/capric triglyceride and mineral oil are added to the oil phase pot, heated to 75 ° C - 80 ° C, and stirred uniformly to obtain an oil phase.
  • the oil phase is slowly added to the water phase, stirring is continued, and the preservative and the essence are added after being evenly mixed, and the mixture is uniformly obtained.
  • the energy-enhancing moisturizing water comprising the loquat leaf extract of the present invention was prepared according to the ingredients and amounts of Table 3.
  • ingredient % concentration (weight) Loquat leaf extract 2.0 1,3-butanediol 8.0 Preservative, water-soluble flavor Moderate amount water To 100
  • the preparation method comprises the following steps: dissolving the eucalyptus leaf extract with 1,3-butanediol, adding to the water, stirring, uniformly adding the preservative and the essence, and stirring uniformly, that is, obtaining.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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Abstract

L'invention concerne les utilisations d'un extrait de feuille de néflier du Japon pour réparer les lésions causées par les ultraviolets et favoriser le métabolisme énergétique. L'invention concerne également les utilisations dudit extrait en tant qu'additif cosmétique présentant une fonction de réparation des lésions causées par les ultraviolets et favorisant le métabolisme énergétique.
PCT/CN2014/092433 2013-11-28 2014-11-28 Herbes médicinales chinoises destinées à réparer les lésions causées par les ultraviolets et à favoriser le métabolisme énergétique, et utilisations de ces herbes dans des produits cosmétiques WO2015078397A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201310625970.6A CN104666145B (zh) 2013-11-28 2013-11-28 一种用于紫外损伤修复和促进能量代谢的中草药及其在化妆品中的应用
CN201310625970.6 2013-11-28

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WO2015078397A1 true WO2015078397A1 (fr) 2015-06-04

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106176377B (zh) * 2016-08-08 2019-03-05 珀莱雅化妆品股份有限公司 一种植物来源的防晒增效组合物及其制备方法
KR102212667B1 (ko) 2018-03-19 2021-02-05 스푸라우트 코포레이션 리미티드 식물 추출액, 그 제조 방법, 그 용도, 그리고 그 식물 추출액을 포함하는 약용 화장품 및 제품
CN108703936A (zh) * 2018-07-17 2018-10-26 佛山市三水区嘉华化学研究院（普通合伙） 一种白背三七防衰老面膜及其制备方法

Citations (4)

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Publication number Priority date Publication date Assignee Title
JP2002255781A (ja) * 2001-03-01 2002-09-11 Pola Chem Ind Inc シワ改善及び予防対応用皮膚外用剤
CN101279996A (zh) * 2007-04-04 2008-10-08 研光通商株式会社 高纯度科罗索酸和高纯度熊果酸的制造方法
CN102293724A (zh) * 2011-08-05 2011-12-28 广东南方洁灵科技实业有限公司 一种含中药复合物的化妆品组合物
CN103027867A (zh) * 2011-09-30 2013-04-10 天津市中科健新材料技术有限公司 晒后卸妆修复湿巾整理液

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62249907A (ja) * 1986-04-22 1987-10-30 Eikoudou:Kk 化粧料
FR2742987B1 (fr) * 1996-01-03 1998-04-03 Lvmh Rech Utilisation dans le domaine de la cosmetique et de la pharmacie, notamment de la dermatologie, d'un extrait d'eriobotrya japonica pour stimuler la synthese des glycosaminoglycanes
KR100684776B1 (ko) * 2004-03-09 2007-02-22 주식회사 한생화장품 비파엽 추출물을 유효성분으로 하는 주름 개선용 화장료 조성물
CN103110558A (zh) * 2011-11-16 2013-05-22 毛雪莲 一种抗皱、增白的海藻面膜及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002255781A (ja) * 2001-03-01 2002-09-11 Pola Chem Ind Inc シワ改善及び予防対応用皮膚外用剤
CN101279996A (zh) * 2007-04-04 2008-10-08 研光通商株式会社 高纯度科罗索酸和高纯度熊果酸的制造方法
CN102293724A (zh) * 2011-08-05 2011-12-28 广东南方洁灵科技实业有限公司 一种含中药复合物的化妆品组合物
CN103027867A (zh) * 2011-09-30 2013-04-10 天津市中科健新材料技术有限公司 晒后卸妆修复湿巾整理液

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CN104666145A (zh) 2015-06-03

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