WO2015078398A1 - Composé de médicaments chinois à base de plantes permettant de réparer un dommage provoqué par les ultraviolets, et son utilisation en cosmétique - Google Patents

Composé de médicaments chinois à base de plantes permettant de réparer un dommage provoqué par les ultraviolets, et son utilisation en cosmétique Download PDF

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Publication number
WO2015078398A1
WO2015078398A1 PCT/CN2014/092435 CN2014092435W WO2015078398A1 WO 2015078398 A1 WO2015078398 A1 WO 2015078398A1 CN 2014092435 W CN2014092435 W CN 2014092435W WO 2015078398 A1 WO2015078398 A1 WO 2015078398A1
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Prior art keywords
peach
extract
peach kernel
compound extract
weight
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PCT/CN2014/092435
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English (en)
Chinese (zh)
Inventor
孙懿
方程
赵亚
陈默
祝乐
戴竟
吕洛
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上海家化联合股份有限公司
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Publication of WO2015078398A1 publication Critical patent/WO2015078398A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/004—Aftersun preparations

Definitions

  • the invention relates to a Chinese herbal compound for ultraviolet damage repair and its application in cosmetics, in particular to a peach peach kernel compound and its application in cosmetics.
  • Ultraviolet rays not only damage the outermost skin cells, but also cause dermal cell necrosis and metabolic disorders.
  • the impurities in the cells cannot be metabolized, causing sunburn, loss of elasticity, premature aging, sensitivity, wrinkles, and skin.
  • the tingling and itching are unbearable, scratching the bleeding, the skin's own resistance to disease and resistance is weakened, and even edema, exudation, formation of folliculitis, sputum and other difficult to cure skin diseases.
  • the understanding of the mechanism of ultraviolet light on skin damage includes oxidative stress, inflammatory reaction, apoptosis, degradation of collagen and elastin.
  • the skin tissue cells will produce oxidative stress, produce excessive reactive oxygen species ROS, destroy the integrity of the cell membrane and the anti-oxidation system inside the cell, further causing cell inflammation, apoptosis and tumor formation.
  • ROS reactive oxygen species
  • excessive ultraviolet radiation causes skin collagen, hyaluronic acid and elastin to degrade, resulting in elastic degeneration, roughness and wrinkles. Therefore, most of the repair methods after the ultraviolet ray damage are based on these mechanisms, and substances having antioxidation, anti-inflammatory, and matrix metalloproteinase inhibition activities are used.
  • ash tree extract effectively removes a large number of free radicals generated in human Fb cells after UVB irradiation, and reduces the expression of MMP-1 mRNA and protein, thereby resisting skin damage after UVB irradiation; for example, marigold flower extract contains ⁇ Carotene, which inhibits the production of wrinkles by inhibiting the activity of hyaluronidase, elastase, and MMP-1, thereby exerting an ultraviolet protection effect.
  • ATP is a key molecule in the metabolism of cell energy. It is the main energy source that skin cells can directly use. It is also an important indicator of the healthy viability of cells. The reduction of ATP leads to the reduction of energy metabolism, and the corresponding functional decline. The most obvious is skin aging, dull acne and so on. New research has found that intense exposure to ultraviolet light can cause a decrease in ATP production, leading to a decrease in energy metabolism and affecting the normal function of skin cells. The increase of ATP can promote the increase of cells after injury, and promote Into the metabolism of cell energy, which is conducive to the repair of skin damage caused by ultraviolet radiation.
  • Peach blossom is the flower of the Prunus persica (L.) Batsch of the Rosaceae plant. The bitterness is flat and the water is swollen.
  • the "Shen Nong's Herbal Classic" records that the peach blossom is "a good color”; the peach kernel is the dry ripe of the Prunus persica (L.) Batsch or the Prunus davidiana (Carr.) Franch. seed. It tastes bitter and sweet, promotes blood circulation, and can moisturize dryness.
  • the two are compatible, activating blood circulation, moistening dryness and diuresis, and can make blood stasis, water and swollen body restore blood and blood circulation, and eliminate qi and blood stasis in the body.
  • the prior art describes the research progress of the skin damage mechanism of ultraviolet rays and natural products having ultraviolet protection.
  • the research progress of the skin damage mechanism of ultraviolet light and the UV-protectant of natural sources is reviewed. Specifically pointed out: long-term exposure of the skin to ultraviolet light can cause skin damage, skin photoaging and even skin cancer and other skin lesions.
  • the main mechanisms of photoaging caused by ultraviolet light are: oxidative stress, inflammatory reaction, apoptosis, degradation of collagen and elastin.
  • UV protective agents At present, flavonoids, terpenoids, tannins and coumarins are mainly studied.
  • Chinese patent application 201110198166.5 discloses a compound Chinese medicine extract and its application in whitening moisturizing anti-aging skin care products. This document mainly discloses a compound Chinese medicine extract and its application in whitening moisturizing anti-aging skin care products.
  • the compound Chinese medicine extract is prepared from the following raw materials by mass: 10 to 50 parts of Selaginella, 10 to 50 parts of peach, 10 to 50 parts of white and 10 to 50 parts of notoginseng.
  • the compound Chinese herbal extract obtained by the above raw materials has an inhibitory effect on the proliferation of tyrosinase and melanocytes, has an excellent whitening effect, and has a promoting effect on proliferation of fibroblasts; in epidermal cell culture, the above-mentioned compound Chinese herbal extracts
  • the production of ceramide has a good promotion effect.
  • the compound Chinese medicine extract is applied to prepare a whitening moisturizing anti-aging skin care product, and the obtained whitening moisturizing anti-aging skin care product has the lasting natural whitening effect, and can improve the metabolism and moisturizing function of the skin.
  • This patent application while also revealing a composition, is not a composition of the peach kernel of the present invention.
  • Cisoka leaf spotting beauty tea and a preparation method thereof discloses a mulberry leaf spotting beauty tea and a preparation method thereof.
  • a mulberry leaf spotting beauty tea and a preparation method thereof are provided, and various raw materials are: mulberry leaves, peach blossoms, raspberries, alfalfa, spatholobus, codonopsis, perrin, gynostemma, angelica, polygonatum, peach kernel, turmeric, incense Attachment, white peony root, Chuanxiong, Danshen, Coix seed, Atractylodes, Peach blossom, White and, Ligustrum lucidum, Campsis, white peony.
  • the invention solves the defects that the mulberry leaf tea is easy to be stuffy yellow, brittle, and the soup color is red, and the polyphenols in the mulberry leaves are exhausted. It may be converted into amino acid, which is beneficial to remove the bitter taste in tea and make it more delicious.
  • the mulberry leaf contains mulberry glycoside F, which has inhibitory effect on the biosynthesis of melanin.
  • mulberry leaf juice has anti-oxidation effect, non-toxic, no Chemical pollution, can be used for facial acne, pigmentation, phlegm, pharyngeal, hair growth, hair care, liver and eyesight treatment, plus some Chinese herbal medicines that promote blood circulation and phlegm, most of these herbs are light, do not affect mulberry tea
  • the taste is easy to accept, and it can better achieve the beauty and remove the pigmentation.
  • the application is directed to mulberry leaf compositions, although peach and peach kernels are added to it, but it is not a major Chinese herbal ingredient.
  • the prior art does not mention the role of the peach peach kernel compound in repairing UVB radiation damage and promoting energy metabolism.
  • the present invention finds for the first time that the peach peach kernel compound has the properties of ultraviolet damage repair and promoting skin cell energy metabolism.
  • the invention aims to provide a Chinese herbal compound extract with ultraviolet damage repair, which can promote ATP synthesis and repair ultraviolet damage caused by UVB. At the same time, it can be added as an efficacy additive to cosmetics for skin care after UV injury.
  • peach peach kernel The extraction process of peach peach kernel is as follows:
  • Peach medicinal materials are soaked in a suitable solvent for about 0.5-1 h, and extracted by the corresponding method.
  • the filtrate is taken, statically filtered, concentrated, and dried to form a powder.
  • the peach kernel is soaked in a suitable solvent for about 0.5-1 h, and extracted by the corresponding method.
  • the filtrate is taken, statically filtered, concentrated, and dried to form a powder.
  • the peach blossom extract and the peach kernel extract were mixed in proportion, and finally a 1% by weight composite extract solution was prepared.
  • the Chinese herbal medicines in the formula may be appropriately enlarged or reduced according to the proportion; suitable solvents include water (distilled water, deionized water, purified water), different concentrations of ethanol solution, different concentrations of polyol solution and other solvents of similar polarity; the extraction method may It is a method of boiling, reflux extraction, dipping, seepage, and the like.
  • the preparation of the compound extract of Peach Blossom Peach can also be carried out by supercritical extraction, subcritical extraction and organic solvent extraction.
  • Solvents for organic solvent extraction include n-hexane, ethyl acetate, diethyl ether, petroleum ether, Medium and low polarity solvents such as acetone, and different concentrations of ethanol, methanol, and polyols.
  • the extraction method may be a method such as reflux extraction, impregnation, or osmosis.
  • ultrasonic or microwave methods can also be used for assisting during the extraction process.
  • the present invention relates to the use of a peach peach kernel compound extract for the repair of ultraviolet damage and the promotion of energy metabolism.
  • the present invention relates to the use of a peach peach kernel compound extract as an additive having ultraviolet damage repair and promoting energy metabolism in cosmetics.
  • the peach peach kernel compound extract is used in an amount of 0.00001 to 100% by weight. In another embodiment, the peach peach kernel compound extract is used in an amount of 0.0001 to 50% by weight. In a preferred embodiment, the peach peach kernel compound extract is used in an amount of from 0.001% to 20% by weight.
  • the cosmetic of the present invention is selected from the group consisting of facial cleansers, lotions, lotions, creams, gels, masks, shampoos, shower gels, and hair conditioners.
  • the cosmetic of the present invention comprises a peach peach kernel compound extract and an acceptable adjuvant.
  • the cosmetic comprises from 0.00001 to 100% by weight of a peach peach kernel compound extract. In another embodiment, the cosmetic comprises 0.0001 to 50% by weight of a peach peach kernel compound extract. In another embodiment, the cosmetic comprises from 0.001% to 20% by weight of the peach peach kernel compound extract.
  • Figure 1 shows the percentage of ATP content of normal cells, UV irradiated cells, and various concentrations of the peach extract of the present invention.
  • # indicates a significant difference in the UVB irradiation group with respect to the normal group; ** indicates a significant difference (p ⁇ 0.01) with respect to the UVB irradiation group.
  • the invention firstly proposes that the peach peach kernel compound has the effects of ultraviolet damage repair and energy metabolism.
  • Peach blossom peach kernel complex provided by the invention The extract can repair the energy loss of cells after UVB irradiation, promote the energy metabolism of skin cells and the synthesis of ATP, which is beneficial to the repair of UV damage.
  • the inventors of the present invention found that the peach peach kernel compound extract has ultraviolet damage repair and promotes energy metabolism.
  • the peach peach kernel compound extract can be added to cosmetics as an efficacy additive.
  • the present invention firstly proposes that the peach peach kernel compound extract has ultraviolet damage repair and promotes energy metabolism, and can be added as a functional additive to cosmetics for ultraviolet damage repair and skin cell energy supplementation.
  • the peach peach kernel compound extract can be in various forms.
  • the application form of the peach peach kernel compound extract may be a cleansing lotion, a lotion, a lotion, a cream, a gel, a mask, a shampoo, a shower gel, a conditioner, and the like which can be applied to human skin.
  • ingredients other than the peach peach kernel extract may be any ingredients required for a cosmetic formulation, such as: water, ethanol, butylene glycol, propylene glycol, oils, emulsifiers, thickeners, preservatives, etc.; Compound functions, such as: adding sunscreen ingredients to promote energy metabolism, sunscreen cosmetics, adding oil control ingredients to promote energy metabolism, oil control cosmetics, adding moisturizing ingredients to promote energy metabolism, moisturizing cosmetics, adding whitening ingredients to promote energy metabolism, whitening cosmetics, adding anti- The aging component becomes an anti-aging cosmetic that promotes energy metabolism and the like.
  • the peach peach kernel compound extract can be used at a concentration of 0.00001-100% by weight.
  • the peach peach kernel compound extract can be used at a concentration of 0.0001 to 50% by weight.
  • the peach peach kernel compound extract is used at a concentration of 0.00001 to 100% by weight.
  • the peach peach kernel compound extract has a concentration of from 0.001% to 50% by weight.
  • the peach peach kernel compound extract is used at a concentration of from 0.001% to 20% by weight.
  • the peach peach kernel compound extract is used at a concentration of from 0.001 to 100 ug/ml. In another embodiment, the peach peach kernel compound extract is used at a concentration of 0.001-50 ug/ml. In another embodiment, the peach peach kernel compound extract is used at a concentration of 0.001 to 10 ug/ml. In another embodiment, the peach peach kernel compound extract is used at a concentration of from 0.01 to 10 ug/ml. In another embodiment, the peach peach kernel compound extract is used at a concentration of 0.1-10 ug/ml. In another embodiment, the peach peach kernel compound extract is used at a concentration of 1-10 ug/ml.
  • the peach peach kernel compound extract can be added to various cosmetics in a ratio of 0.00001-100% by weight.
  • the peach peach kernel compound extract may be used in an amount of 0.00001 to 25% by weight, for example 0.0001 to 50% by weight, for example 0.001 to 75% by weight, for example 0.1 to 100% by weight.
  • the peach peach kernel compound extract in the cosmetic is used in an amount of 0.0001 to 50% by weight.
  • the peach peach kernel compound extract is used in the cosmetic in an amount of 0.001 to 20% by weight.
  • the weight ratio of the peach flower extract and the peach kernel extract in the peach peach kernel compound extract may be any ratio.
  • the weight ratio of peach blossom extract and peach kernel extract in the peach peach kernel compound extract is 3:7.
  • Example 1 Repair of skin cell energy damage caused by UVB irradiation of peach peach kernel
  • a 1% by weight peach peach kernel extract was removed and diluted to 10 ug/ml, 1 ug/ml, and 0.1 ug/ml with PBS buffer to obtain a sample solution.
  • the adjusted concentration is inoculated into the cell plate.
  • the cells were placed under a UVB irradiation apparatus, and normal medium and medium containing the extract of the example were added to continue the culture incubation.
  • test solution in the kit After incubation for a period of time, add the test solution in the kit to each well, shake, and stabilize the fluorescence at room temperature. The instrument will detect the reading.
  • the fluorescence unit RLU measured in each well was recorded, and the average of 3 replicate wells in each group was averaged.
  • the experimental results were subjected to t test, P ⁇ 0.05, indicating significant difference; p ⁇ 0.01 indicates that the difference was very significant.
  • the percentage value of ATP content of each unit of fluorescence was calculated based on 100% of normal cells.
  • Peach Blossom Peach has UV damage repair and promoted cell energy metabolism. Even at low concentrations (for example, 0.1 ug / ml concentration), Peach Blossom Peach Compound extract has a good repair effect on cell energy loss after UVB UV irradiation, promotes the synthesis of ATP, and maintains the energy metabolism level of skin cells. As shown in Table 1 and Figure 1, the repair rate can reach more than 75% at 10ug/ml, and the repair rate can reach nearly 50% at a low dose concentration of 0.1ug/ml.
  • Peach peach kernel extract concentration Protection rate (%) 10ug/ml 76.43% 1ug/ml 59.19% 0.1ug/ml 48.15%
  • An energy metabolism anti-aging cream comprising the peach peach kernel compound extract of the present invention was prepared according to the ingredients and amounts of Table 2.
  • the preparation method comprises the steps of: dissolving the peach peach extract with 1,3-butanediol, adding it to water, and stirring uniformly to obtain an aqueous phase.
  • the oil phase is slowly added to the water phase, stirring is continued, and the preservative and the essence are added after being evenly mixed, and the mixture is uniformly obtained.
  • the energy-enhancing moisturizing water containing the peach peach kernel compound extract of the present invention was prepared according to the ingredients and amounts of Table 3.
  • Preparation method first dissolve the peach peach kernel extract with 1,3-butanediol, then add to the water, stir, evenly add the preservative and flavor, and stir evenly.

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Abstract

La présente invention concerne les utilisations d'un composé de fleur de pêche et de graine de pêche pour réparer un dommage provoqué par les ultraviolets et pour activer le métabolisme énergétique, et les utilisations du composé de fleur de pêche et de graine de pêche en tant qu'additif cosmétique ayant une fonction de réparation d'un dommage provoqué par les ultraviolets et d'activation du métabolisme énergétique.
PCT/CN2014/092435 2013-11-28 2014-11-28 Composé de médicaments chinois à base de plantes permettant de réparer un dommage provoqué par les ultraviolets, et son utilisation en cosmétique WO2015078398A1 (fr)

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CN201310626873.9A CN104666147B (zh) 2013-11-28 2013-11-28 一种用于紫外损伤修复的中草药复方及其在化妆品中应用
CN201310626873.9 2013-11-28

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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN113476364A (zh) * 2021-07-07 2021-10-08 科丝美诗(中国)化妆品有限公司 一种用于改善皮肤微循环的植物提取组合物及其应用

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CN108042476B (zh) * 2018-02-01 2020-08-07 广州鹰远生物科技有限公司 一种含桃花提取物的乳液

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101700217A (zh) * 2009-09-16 2010-05-05 许庆华 凹凸棒中草药防晒霜

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1043458C (zh) * 1994-11-03 1999-05-26 肖利平 治疗肝炎、肝硬化、肝坏死中药冲剂
CN1180560A (zh) * 1997-08-29 1998-05-06 车兴泉 缰猪治疗药物及其制造方法
CN101438745A (zh) * 2007-11-19 2009-05-27 蒋佃水 桃花养颜奶茶
CN101336883B (zh) * 2008-07-31 2010-06-09 索建兰 美白中药面膜及其制备工艺
CN101700211B (zh) * 2009-09-16 2010-09-29 许庆华 凹凸棒中草药防晒粉

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101700217A (zh) * 2009-09-16 2010-05-05 许庆华 凹凸棒中草药防晒霜

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113476364A (zh) * 2021-07-07 2021-10-08 科丝美诗(中国)化妆品有限公司 一种用于改善皮肤微循环的植物提取组合物及其应用

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