WO2015010166A1 - Compositions and methods for dental mineralization - Google Patents

Compositions and methods for dental mineralization Download PDF

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Publication number
WO2015010166A1
WO2015010166A1 PCT/AU2014/050144 AU2014050144W WO2015010166A1 WO 2015010166 A1 WO2015010166 A1 WO 2015010166A1 AU 2014050144 W AU2014050144 W AU 2014050144W WO 2015010166 A1 WO2015010166 A1 WO 2015010166A1
Authority
WO
WIPO (PCT)
Prior art keywords
dental
solution
acp
acfp
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/AU2014/050144
Other languages
English (en)
French (fr)
Inventor
Eric Charles Reynolds
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Melbourne
Original Assignee
University of Melbourne
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2013902815A external-priority patent/AU2013902815A0/en
Priority to NZ71616314A priority Critical patent/NZ716163A/en
Priority to CN201480039244.9A priority patent/CN105530909A/zh
Priority to CA2918441A priority patent/CA2918441C/en
Priority to PL14830019T priority patent/PL3024428T3/pl
Priority to SG11201600137UA priority patent/SG11201600137UA/en
Priority to US14/906,395 priority patent/US10695370B2/en
Priority to AU2014295815A priority patent/AU2014295815B2/en
Priority to KR1020167004696A priority patent/KR102221531B1/ko
Priority to DK14830019.7T priority patent/DK3024428T3/da
Priority to JP2016528265A priority patent/JP6621406B2/ja
Priority to EP14830019.7A priority patent/EP3024428B1/en
Priority to RU2016103090A priority patent/RU2697878C2/ru
Application filed by University of Melbourne filed Critical University of Melbourne
Priority to MX2016001005A priority patent/MX378581B/es
Publication of WO2015010166A1 publication Critical patent/WO2015010166A1/en
Priority to IL243553A priority patent/IL243553B/en
Priority to PH12016500127A priority patent/PH12016500127A1/en
Anticipated expiration legal-status Critical
Priority to US16/852,983 priority patent/US11351193B2/en
Priority to US17/832,556 priority patent/US11717537B2/en
Priority to US18/214,964 priority patent/US12128068B2/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/20—Halogens; Compounds thereof
    • A61K8/21—Fluorides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/24—Phosphorous; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions

Definitions

  • Non-limiting examples of bases suitable for use in the invention include hydroxides, chlorides, borates, phosphates including hydrogen phosphates and dihydrogen phosphates, citrates, carbonates, bicarbonates, hypochlorites (such as sodium hypochlorite), amines and any salt forms thereof including an alkali metal sait forms
  • suitable pharmaceutically acceptable bases include ammonium hydroxide, sodium hydroxide, potassium hydroxide, lithium hydroxide, calcium hydroxide, magnesium hydroxide, ferrous hydroxide, zinc hydroxide, sodium hypochlorite, copper hydroxide, aluminum hydroxide, ferric hydroxide, isopropy!amine, trimethylamine, diethylamine, triethylamine, tripropylamine, ethanolamine, 2-dimethylaminoethanol, 2-diethyiaminoethanol, lysine, arginine, histidine or urea.
  • the ACP and/or ACFP is phosphopeptide (PP)-stabilized.
  • the phosphopeptide (as defined below) is a casein phosphopeptide.
  • the ACP or ACFP is in the form of a casein phosphopeptide stabilized ACP or ACFP complex.
  • a compound which is capable of increasing or maintaining the pH of a solution includes a compound which can accept hydrogen cations (protons) or, more generally, donate a pair of valence electrons.
  • the compound may commonly be a base.
  • the compound is capable of increasing the pH of a solution that has an acidic pH (i.e. (ess than pH 7).
  • the compound is capable of raising the pH of intra-lesion fluid of a dental lesion from 6 to 7.5.
  • a compound which is capabl of increasing or maintaining the pH of a solution is an alkali which has the capacity to release hydroxide ions.
  • a phosphopeptide stabilized amorphous calcium phosphate (ACP) or amorphous calcium fluoride phosphate (ACFP) complex may also include wherein the ACP in the complex has tightly bound and loosely bound calcium, wherein the tightly bound calcium in the complex is less than the tightly bound calcium in an AC or ACFP complex formed at a pH of 7.0 and the ACP or ACFP is predominantly in a basic form, obtainable or obtained by a method comprising:
  • a method of treating or preventing one or more of each of dental caries, tooth decay, dental erosion and fluorosis comprising the steps of administering a compound capable of increasing or maintaining the pH of a solution to the teeth of a subject followed by administering an ACP or ACFP complex or composition.
  • Topical administration of the complex is preferred.
  • the method preferably includes the administration of the complex in a formulation as described above.
  • One example of a mineralizing composition or agent comprises the following (in decreasing order of proportion):
  • Recaldent® (CPP-ACP) powder was dry blended with CaHP04 powder in the ratio CPP-ACP;CaHP0 4 equals 1 ;10 on a weight basis. This powder was then added to sugar-free gum and toothpaste formulations at 1 -5% w/w.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Nutrition Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physiology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cosmetics (AREA)
  • Dental Preparations (AREA)
  • Confectionery (AREA)
  • Fodder In General (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Dairy Products (AREA)
PCT/AU2014/050144 2013-07-23 2014-07-23 Compositions and methods for dental mineralization Ceased WO2015010166A1 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
MX2016001005A MX378581B (es) 2013-07-23 2014-07-23 Composiciones y metodos para la mineralizacion dental.
EP14830019.7A EP3024428B1 (en) 2013-07-23 2014-07-23 Compositions and methods for dental mineralization
CA2918441A CA2918441C (en) 2013-07-23 2014-07-23 A base and phosphopeptide stabilized amorphous calcium phosphate (acp) and/or amorphous calcium fluoride phosphate (acfp) for use in promoting remineralisation
PL14830019T PL3024428T3 (pl) 2013-07-23 2014-07-23 Kompozycje i sposoby mineralizacji zębów
SG11201600137UA SG11201600137UA (en) 2013-07-23 2014-07-23 Compositions and methods for dental mineralization
US14/906,395 US10695370B2 (en) 2013-07-23 2014-07-23 Compositions and methods for dental mineralization
AU2014295815A AU2014295815B2 (en) 2013-07-23 2014-07-23 Compositions and methods for dental mineralization
KR1020167004696A KR102221531B1 (ko) 2013-07-23 2014-07-23 치아 광화를 위한 조성물 및 방법
DK14830019.7T DK3024428T3 (da) 2013-07-23 2014-07-23 Sammensætninger og fremgangsmåder til dental mineralisering
NZ71616314A NZ716163A (en) 2013-07-23 2014-07-23 Compositions and methods for dental mineralization
RU2016103090A RU2697878C2 (ru) 2013-07-23 2014-07-23 Композиции и способы для минерализации зубов
CN201480039244.9A CN105530909A (zh) 2013-07-23 2014-07-23 用于牙齿矿化的组合物及方法
JP2016528265A JP6621406B2 (ja) 2013-07-23 2014-07-23 歯の石灰化のための組成物および方法
IL243553A IL243553B (en) 2013-07-23 2016-01-11 Preparations and methods for dental mineralization
PH12016500127A PH12016500127A1 (en) 2013-07-23 2016-01-20 Compositions and methods for dental mineralization
US16/852,983 US11351193B2 (en) 2013-07-23 2020-04-20 Compositions and methods for dental mineralization
US17/832,556 US11717537B2 (en) 2013-07-23 2022-06-03 Compositions and methods for dental mineralization
US18/214,964 US12128068B2 (en) 2013-07-23 2023-06-27 Compositions and methods for dental mineralization

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AU2013902815A AU2013902815A0 (en) 2013-07-23 Compositions and methods for dental mineralization
AU2013902815 2013-07-23

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US14/906,395 A-371-Of-International US10695370B2 (en) 2013-07-23 2014-07-23 Compositions and methods for dental mineralization
US16/852,983 Continuation US11351193B2 (en) 2013-07-23 2020-04-20 Compositions and methods for dental mineralization

Publications (1)

Publication Number Publication Date
WO2015010166A1 true WO2015010166A1 (en) 2015-01-29

Family

ID=52392515

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/AU2014/050144 Ceased WO2015010166A1 (en) 2013-07-23 2014-07-23 Compositions and methods for dental mineralization

Country Status (18)

Country Link
US (4) US10695370B2 (cg-RX-API-DMAC7.html)
EP (1) EP3024428B1 (cg-RX-API-DMAC7.html)
JP (2) JP6621406B2 (cg-RX-API-DMAC7.html)
KR (1) KR102221531B1 (cg-RX-API-DMAC7.html)
CN (1) CN105530909A (cg-RX-API-DMAC7.html)
AU (1) AU2014295815B2 (cg-RX-API-DMAC7.html)
CA (1) CA2918441C (cg-RX-API-DMAC7.html)
DK (1) DK3024428T3 (cg-RX-API-DMAC7.html)
IL (1) IL243553B (cg-RX-API-DMAC7.html)
MX (1) MX378581B (cg-RX-API-DMAC7.html)
MY (1) MY180623A (cg-RX-API-DMAC7.html)
NZ (1) NZ716163A (cg-RX-API-DMAC7.html)
PH (1) PH12016500127A1 (cg-RX-API-DMAC7.html)
PL (1) PL3024428T3 (cg-RX-API-DMAC7.html)
RU (1) RU2697878C2 (cg-RX-API-DMAC7.html)
SG (1) SG11201600137UA (cg-RX-API-DMAC7.html)
TW (1) TWI679991B (cg-RX-API-DMAC7.html)
WO (1) WO2015010166A1 (cg-RX-API-DMAC7.html)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10695370B2 (en) 2013-07-23 2020-06-30 The University Of Melbourne Compositions and methods for dental mineralization
WO2020181334A1 (en) * 2019-03-13 2020-09-17 The University Of Melbourne Compositions and methods for promoting mineralization
WO2020181335A1 (en) * 2019-03-13 2020-09-17 The University Of Melbourne Concealment of hypomineralised lesions
US11504305B2 (en) 2006-02-09 2022-11-22 The University Of Melbourne Fluoride composition and methods for dental mineralization
US11564873B2 (en) 2013-12-24 2023-01-31 The University Of Melbourne Stabilized stannous compositions
US11717536B2 (en) 2017-03-14 2023-08-08 The University Of Melbourne Treatment for periodontitis
US12303548B2 (en) 2017-03-14 2025-05-20 The University Of Melbourne Complexes for treating sensitivity

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CN112426376B (zh) * 2020-12-21 2023-07-25 深圳爱尔创数字口腔有限公司 一种漱口水及其制备方法
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