WO2014016917A1 - Nutriment liquide acide - Google Patents

Nutriment liquide acide Download PDF

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Publication number
WO2014016917A1
WO2014016917A1 PCT/JP2012/068783 JP2012068783W WO2014016917A1 WO 2014016917 A1 WO2014016917 A1 WO 2014016917A1 JP 2012068783 W JP2012068783 W JP 2012068783W WO 2014016917 A1 WO2014016917 A1 WO 2014016917A1
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WO
WIPO (PCT)
Prior art keywords
acidic liquid
liquid nutrient
protein
oil
acid
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PCT/JP2012/068783
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English (en)
Japanese (ja)
Inventor
泰代 谷
Original Assignee
テルモ株式会社
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Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Priority to JP2014526652A priority Critical patent/JP5902815B2/ja
Priority to PCT/JP2012/068783 priority patent/WO2014016917A1/fr
Publication of WO2014016917A1 publication Critical patent/WO2014016917A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/011—Hydrolysed proteins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Definitions

  • the present invention relates to an acidic liquid nutrient.
  • Enteral nutrition is a physiological route of nutrition via the gastrointestinal tract that can solve the problems associated with high-calorie infusion methods. It is an important nutritional method for difficult patients. Liquid enteral nutrients used for enteral nutrition require that various nutrients necessary for the body (proteins, carbohydrates, lipids, minerals, vitamins, water, etc.) be included in sufficient amounts and in a well-balanced manner. In particular, the majority of the elderly are said to have protein and energy undernutrition (PEM) epilepsy and hypoproteinemia. It is important.
  • PEM protein and energy undernutrition
  • liquid enteral nutrients MPC, casein, soybean protein, and the like are used as protein raw materials, but many of the protein raw materials have an isoelectric point on the acidic side. It is. In the protein raw material, protein aggregation or precipitation occurs in the acidic region. Therefore, most of the liquid enteral nutrients currently on the market are of the neutral type with a pH of about 6.5 to 7.5.
  • enteral nutrients conventionally used may partially aggregate when the protein component comes into contact with gastric juice that is in the acidic range, which tends to cause clogging of the tube and reduce the protein content. It was difficult to increase.
  • the neutral type tends to be sweet in taste and flavor, has no refreshing flavor variations, and is difficult to ingest continuously.
  • Patent Document 1 A method for producing an acidic gel-like food is disclosed (Patent Document 1), characterized in that it is subjected to a treatment and then cooled to cause gelation.
  • acid-resistant water containing 20 to 50% by weight of fat (A), 0.5 to 5.0% by weight of whey protein (B), and 1.0 to 5.0% by weight of organic acid monogly (C) Oil-type emulsion composition.
  • a gel food comprising a gelling agent such as thickening polysaccharide or gelatin
  • the acid-resistant oil-in-water emulsion composition is blended in an amount of 5 to 40% by weight in the gel food, and the pH is 3.0.
  • Gel foods and the like characterized by adjusting to ⁇ 4.2 are disclosed (Patent Document 2).
  • Patent Documents 1 and 2 above various types of acidic-type foods and drinks containing proteins are known.
  • storage stability is improved by hardening with a gelling agent. It is a highly gelled food product, and it is difficult to say that protein aggregation is suppressed in the acidic region.
  • Patent Document 2 is a gel-like food in which organic acid monoglyceride is an essential raw material and imparts stability by increasing the viscosity, and does not improve protein aggregation itself in the acidic region. It is difficult to say that the stability of the product is satisfactory.
  • An object of the present invention is to provide an acidic liquid liquid food having high protein stability, moderate viscosity, and excellent tube fluidity even under acidic conditions.
  • the present inventor has found that the above problems can be solved by setting the blending ratio of protein and organic acid, and has completed the present invention. That is, the present invention relates to the following acidic liquid nutrient.
  • the acidic liquid nutrient of the present invention is an acidic liquid nutrient that has high stability and does not cause tube clogging even when the nutrient is administered through a tube. Therefore, it is possible to reliably and easily ingest nutrition without the need for readjustment of the flow rate during nursing care.
  • the acidic liquid nutrient suitable for the enteral nutrition method of the present invention is characterized in that a carbohydrate, a protein source, a lipid, and a predetermined amount of an organic acid are blended in the nutrient.
  • the acidic liquid nutrient contains a sugar, a protein source, a lipid, and a predetermined amount of an organic acid.
  • Organic acid is not particularly limited, and acetic acid, citric acid, succinic acid, lactic acid, malic acid, tartaric acid, gluconic acid and the like can be used. These acidulants may be used alone or in combination of two or more.
  • the blending ratio of the organic acid in the acidic liquid nutrient is preferably 0.15 to 0.45 part, more preferably 0.19 to 0.40 part with respect to 1 part of the protein source.
  • Nutrients preferably include carbohydrates, protein sources, and lipids.
  • the nutrient may further contain at least one selected from the group consisting of vitamins, minerals, and dietary fiber as an optional component.
  • the total amount of nutrients in the acidic liquid nutrient is preferably 8 to 60% by mass, and more preferably 15 to 40% by mass.
  • Carbohydrates are also called carbohydrates and serve as energy sources.
  • the carbohydrate is not particularly limited as long as it is absorbed into the living body and becomes an energy source, and examples thereof include monosaccharides, disaccharides, and polysaccharides.
  • Specific examples of monosaccharides include glucose (glucose), fructose (fructose), galactose and the like.
  • Specific examples of the disaccharide include sucrose (sucrose), lactose (lactose), maltose (malt sugar), isomaltose, trehalose and the like.
  • Specific examples of the polysaccharide include starch (amylose, amylopectin), dextrin and the like. Of these, dextrin is preferably used.
  • Dextrin is a general term for substances in which several ⁇ -glucoses are polymerized by glycosidic bonds, and can be obtained by hydrolysis of starch. Since dextrin has a slow degradation rate in the small intestine and is slowly absorbed, it can prevent a rapid increase in blood sugar. Further, by using dextrin, the osmotic pressure of the acidic liquid nutrient can be reduced, and osmotic diarrhea can be prevented.
  • the dextrin either a high molecular dextrin having a high degree of polymerization of ⁇ -glucose or a low molecular dextrin having a low degree of polymerization of ⁇ -glucose may be used, but a high molecular dextrin capable of further reducing the osmotic pressure should be used. Is preferred.
  • the low molecular dextrin is also called maltodextrin and is usually a polymer of 3 to 5 ⁇ -glucose.
  • Dextrin may be prepared by itself or a commercially available product may be used.
  • known starches such as corn, waxy corn, wheat, rice, waxy rice, waxy miro, beans (broad beans, mung beans, red beans, etc.), potatoes, sweet potatoes, tapioca, etc. It can be prepared by hydrolysis by a known method.
  • examples of commercially available dextrin include TK-16 (manufactured by Matsutani Chemical Industry Co., Ltd.) and the like, which can be preferably used.
  • the above saccharides may be used alone or in admixture of two or more.
  • the content of the saccharide in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied, but is preferably 5 to 30% by mass with respect to the total amount of the acidic liquid nutrient.
  • the protein source is not particularly limited, and known proteins can be used.
  • Amino acids include essential amino acids such as valine, leucine, isoleucine, lysine, methionine, phenylalanine, threonine, tryptophan, histidine; and glycine, alanine, serine, cysteine, asparagine, glutamine, proline, tyrosine, aspartic acid, glutamic acid, arginine, etc. Of the non-essential amino acids.
  • modified amino acids such as 4-hydroxyproline, 5-hydroxylysine, ⁇ -carboxyglutamic acid, O-phosphoserine, O-phosphotyrosine, N-acetylserine, N ⁇ -methylarginine, pyroglutamic acid, M-formylmethionine; Special amino acids such as ornithine, citrulline, ⁇ -aminobutyric acid (GABA), thyroxine, S-adenylmethionine can also be included.
  • the amino acids may be stereoisomers (enantiomers, diastereomers), positional isomers, or a mixture thereof.
  • the amino acid may be in the form of an inorganic acid salt (hydrochloride or the like), an organic acid salt (acetate or the like), or an ester body (methyl ester or the like) that can be hydrolyzed in vivo.
  • plant proteins examples include proteins contained in grains such as rice and beans such as soybeans and tofu.
  • the soy protein may have a health function such as binding to bile acid to promote cholesterol excretion.
  • whey protein and soybean protein made from milk (whey) as raw materials, and more preferably whey protein.
  • whey proteins include whey protein concentrate (WPC), whey protein isolate (WPI), and hydrolyzed whey peptide (WPH).
  • WPC, WPI, soybean protein, and the like may be commercially available.
  • WPC392 manufactured by Fonterra
  • WPC80 manufactured by Fontera
  • soy protein Prolina (registered trademark) 900 (registered trademark) Fuji Oil Co., Ltd.), Prolina (registered trademark) 300 (Fuji Oil Co., Ltd.) and the like.
  • the above protein source, amino acid or peptide may be used alone or in combination of two or more.
  • the content of the protein source in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied, but is preferably 2 to 15% by mass with respect to the total amount of the acidic liquid nutrient.
  • Lipids can be a source of energy, biomembrane constituents, steroid hormones and bile acids.
  • the lipid is not particularly limited, and examples thereof include saturated fatty acids, unsaturated fatty acids, vegetable oils, animal fats and oils, and fish oils.
  • saturated fatty acids examples include caprylic acid, capric acid, lauric acid, palmitic acid, stearic acid and the like.
  • unsaturated fatty acids include oleic acid, palmitoleic acid, linoleic acid, arachidonic acid, ⁇ -linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
  • EPA and DHA it can have functions, such as a blood cholesterol raise inhibitory effect and a neutral fat rise inhibitory effect.
  • Vegetable oils include coconut oil, corn oil, cottonseed oil, olive oil, palm oil, palm kernel oil, peanut oil, rapeseed oil, safflower oil (safflower oil), sesame oil, soybean oil, sunflower oil, almond oil, cashew oil, hazelnut Oil, macadamia nut oil, mongolian oil, pecan oil, pine nut oil, pistachio oil, walnut oil, gourd seed oil, buffalo pumpkin oil, pumpkin seed oil, watermelon seed oil, amaranth oil, apricot oil, apple oil, argan oil , avocado oil, babas oil, moringa oil, borneo oil, cape chestnut oil, cocoa butter, carob oil, kofne palm oil, coriander seed oil, dica oil, flaxseed oil, grape seed oil, hemp oil, kapok seed oil, lale mantia oil , Marula oil, Meadow foam oil, mustard oil, Tsumug butter, okra oil, papaya oil, perilla oil
  • Animal fats include lard (pig fat), head (tallow), milk fat, and the like.
  • Fish oil includes fish oil such as mackerel, salmon, yellowtail, sardine, saury.
  • linoleic acid and ⁇ -linolenic acid that cannot be synthesized in vivo by humans, or lipids containing these.
  • the above lipids may be used alone or in combination of two or more.
  • the lipid content in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied, but is preferably 1 to 8% by mass with respect to the total amount of the acidic liquid nutrient.
  • Vitamins are a general term for organic compounds other than carbohydrates, amino acids or peptides, and lipids that are necessary for maintaining the nutritional state of organisms.
  • Vitamin A retinol
  • vitamin D ergocalciferol, cholecalciferol
  • vitamin E tocopherol, tocotrienol
  • vitamin K phytoquinone, menaquinone
  • vitamin B1 thiamine
  • vitamin B2 Roboflavin
  • vitamin B3 niacin
  • vitamin B5 pantothenic acid
  • vitamin B6 pyridoxal, pyridoxamine, pyridoxine
  • vitamin B7 biotin
  • vitamin B9 folic acid
  • vitamin B12 cyanocobalamin, hydroxocobalamin
  • vitamin C water-soluble vitamins such as (ascorbic acid). These vitamins may be used alone or in combination of two or more.
  • the content of vitamins in the acidic liquid nutrient can be adjusted as appropriate by the subject to be applied. Normally, fat-soluble vitamins are added in an amount that does not cause excess disease, and water-soluble vitamins are not limited in the amount added.
  • the preferable content of each vitamin per 100 g of acidic liquid nutrient is as follows.
  • Fat-soluble vitamin Vitamin A preferably 0 to 3000 ⁇ g, more preferably 20 to 200 ⁇ g Vitamin D: preferably 0.1-50 ⁇ g, more preferably 0.1-5.0 ⁇ g Vitamin E: preferably 0.2 to 800 mg, more preferably 1 to 10 mg Vitamin K: preferably 0.5 to 1000 ⁇ g, more preferably 2 to 50 ⁇ g
  • Water-soluble vitamin Vitamin B1 preferably 0.01 to 40 mg, more preferably 0.1 to 10 mg Vitamin B2: preferably 0.01-20 mg, more preferably 0.05-10 mg Niacin: preferably 0.1 to 300 mg NE, more preferably 0.5 to 60 mg NE Pantothenic acid: preferably 0.1 to 55 mg, more preferably 0.2 to 30 mg Vitamin B6: preferably 0.01-60 mg, more preferably 0.1-30 mg Biotin: preferably 0.1 to 1000 ⁇ g, more preferably 1 to 100 ⁇ g Folic acid: preferably 1-1000 ⁇ g, more preferably 10-200 ⁇ g Vitamin B12: preferably 0.01-100 ⁇ g, more preferably 0.2-60 ⁇ g Vitamin C: preferably 1-2000 mg, more preferably 5-1000 mg
  • Minerals are elements other than organic compounds that are necessary for maintaining the nutritional state of living organisms.
  • Examples of the mineral include quasi-major elements such as sodium, potassium, calcium, phosphorus and magnesium; essential trace elements such as iron, zinc, copper, iodine, manganese, selenium, chromium and molybdenum. These minerals may be used alone or in combination of two or more.
  • the content of mineral in the acidic liquid nutrient can be adjusted as appropriate by the subject to be applied.
  • the preferable content of each mineral per 100 g of acidic liquid nutrient is as follows.
  • Semi-major element sodium preferably 5 to 6000 mg, more preferably 10 to 3500 mg Potassium: preferably 1 to 3500 mg, more preferably 25 to 1800 mg Calcium: preferably 10-2300 mg, more preferably 30-300 mg Phosphorus: preferably 1 to 3500 mg, more preferably 25 to 1500 mg Magnesium: preferably 1 to 740 mg, more preferably 10 to 150 mg
  • Essential trace element Iron preferably 0.1 to 55 mg, more preferably 1 to 10 mg Zinc: preferably 0.1-30 mg, more preferably 1-15 mg Copper: preferably 0.01 to 10 mg, more preferably 0.06 to 6 mg Iodine: preferably 0.1 to 3000 ⁇ g, more preferably 1 to 150 ⁇ g Manganese: preferably 0.01 to 11 mg, more preferably 0.1 to 4 mg Selenium: preferably 0.1 to 450 ⁇ g, more preferably 1 to 35 ⁇ g Chromium: preferably 0.1 to 40 ⁇ g, more preferably 1 to 35 ⁇ g Molybdenum: preferably 0.1 to 320 ⁇ g, more preferably 1 to 25 ⁇ g
  • Dietary fiber can have functions such as reduced nutrient utilization, reduced plasma cholesterol, improved blood glucose response, improved colon function, and prevention of colon cancer.
  • dietary fiber may be fermented by intestinal bacteria and converted to short chain fatty acids, carbon dioxide gas, hydrogen gas, methane gas, and the like. Among these, since short chain fatty acids are absorbed in the large intestine, dietary fiber may be an energy source.
  • the dietary fiber is not particularly limited, but is insoluble dietary fiber such as cellulose, hemicellulose, lignin, insoluble pectin, chitin, chitosan, psyllium seed, low molecular weight sodium alginate; water-soluble pectin, guar gum, konjac mannan, glucomannan, alginic acid , Agar, chemically modified polysaccharide, polydextrose, indigestible oligosaccharide, maltitol, inulin, carrageenan, wheat bran, indigestible dextrin (eg, Pine Fiber C (manufactured by Matsutani Chemical Co., Ltd.), polydextrose, guar gum decomposition And water-soluble dietary fiber such as food.
  • insoluble dietary fiber such as cellulose, hemicellulose, lignin, insoluble pectin, chitin, chitosan, psyllium seed, low molecular weight sodium
  • dietary fibers may be used alone or in combination of two or more.
  • the content of dietary fiber in the acidic liquid nutrient can be adjusted as appropriate by the subject to be applied.
  • the acidic liquid nutrient according to the present invention preferably contains moisture.
  • the water content in the acidic liquid nutrient can be adjusted as appropriate depending on the subject to be applied, the desired viscosity, etc., but is preferably 30 to 90% by mass with respect to the total amount of the acidic liquid nutrient. From the viewpoint of the above, it is more preferably 50 to 90% by mass.
  • the acidic liquid nutrient according to the present embodiment may further contain other known components such as the following components.
  • a health function component is a component that exhibits a certain function for a living body when ingested.
  • resistant oligosaccharide sugar alcohol, calcium citrate malate (CCM) and casein phosphopeptide (CPP), chitosan, L-arabinose, guava leaf polyphenol, wheat albumin, bean extract, diacylglycerol, diacylglycerol plant Sterols, soy isoflavones, milk basic proteins and the like.
  • the indigestible oligosaccharide is a saccharide whose molecular weight is not as large as that of a polysaccharide (about 300 to 3,000) among compounds in which monosaccharides are bound by glycosidic bonds.
  • the indigestible oligosaccharides are not degraded by human digestive enzymes, but those digested by human digestive enzymes can be included in the above-mentioned carbohydrates. Ingestion of indigestible oligosaccharides can provide a bowel regulation effect.
  • the indigestible oligosaccharide is not particularly limited, and examples thereof include xylooligosaccharide, fructooligosaccharide, soybean oligosaccharide, isomaltooligosaccharide, dairy oligosaccharide, lactulose, and galactooligosaccharide. These indigestible oligosaccharides may be used alone or in combination of two or more. The content of the indigestible oligosaccharide in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.
  • Sugar alcohol is a kind of sugar produced by reducing the carbonyl group of aldose or ketose, and is poorly absorbed from the small intestine into the body and is not easily caloric. Sugar alcohol is difficult to be metabolized to acid by oral bacteria and can prevent plaque formation. The sugar alcohol can be used as a low calorie sweetener.
  • sugar alcohols examples include erythritol, maltitol, palatinose and the like. These sugar alcohols may be used alone or in admixture of two or more.
  • the content of the sugar alcohol in the acidic liquid nutrient can be adjusted as appropriate by the subject to be applied.
  • CCM and CPP can promote calcium absorption and promote bone formation.
  • the CCM and CPP may be used alone or in combination.
  • CCM and CPP are preferably used in combination with calcium.
  • the contents of CCM and CPP in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.
  • Food additive The food additive is used for the purpose of processing or storing the food by adding, mixing, moistening or other methods to the food.
  • food additives for example, zinc gluconate and copper gluconate, ascorbic acid 2-glucoside, cyclodextrin, preservatives, fungicides, antioxidants, coloring agents, sweeteners, A pH adjuster, a sour agent, an emulsifier, a fragrance
  • Zinc gluconate and copper gluconate are gluconates utilizing high chelating ability of gluconic acid with heavy metal ions. Since it becomes easy to be absorbed when it is made into the form of gluconate, zinc and copper can be absorbed effectively.
  • the zinc gluconate and copper gluconate may be used alone or in combination.
  • the content of zinc gluconate and copper gluconate in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.
  • Ascorbic acid 2-glucoside is a compound in which glucose is ⁇ -coordinated to the hydroxyl group at the 2-position of vitamin C (ascorbic acid) and is more stable than normal vitamin C because it is not attacked by oxygen. C derivative. Vitamin C can be efficiently absorbed by ascorbic acid 2-glucoside. The content of ascorbic acid 2-glucoside in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.
  • Cyclodextrin is a cyclic oligosaccharide having a cyclic structure in which glucose is bound by a glucoside bond. Those consisting of 6 glucoses are called ⁇ -cyclodextrin, those consisting of 7 glucoses are called ⁇ -cyclodextrin, and those consisting of 8 glucoses are called ⁇ -cyclodextrin. Cyclodextrins can have functions such as an allergy suppressing effect, a blood sugar level increase suppressing effect, and an emulsifying action. The said cyclodextrin may be used independently or may be used in mixture of 2 or more types. The content of cyclodextrin in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.
  • the antioxidant has a function of preventing deterioration of the acidic liquid nutrient due to oxidation. Although it does not restrict
  • the colorant has a function of beautifying the acidic liquid nutrient. Although it does not restrict
  • dye Edible red No. 2, No. 3, No. 40, No. 102, No. 104, No. 105, and No. 106, Edible blue No. 1 and No. 2, Edible yellow No. 4 And No. 5, Edible Green No.
  • ⁇ -carotene water-soluble anato, chlorophyll derivatives (chlorophyll a, chlorphyll b, copper chlorophyll, copper chlorophyllin sodium, iron chlorophyllin sodium, etc.), riboflavin, iron sesquioxide, titanium dioxide Safflower yellow pigment, cochineal pigment, gardenia yellow pigment, turmeric pigment, red cabbage pigment, beet red, grape skin pigment, paprika pigment, caramel and the like can be used. These colorants may be used alone or in admixture of two or more.
  • the sweetener has a function of imparting sweetness to the acidic liquid nutrient.
  • the sweetener is not particularly limited, but saccharin and its sodium salt, xylitol, aspartame, sucralose, acesulfame potassium, dulcin, cyclamate, neotame, trehalose, erythritol, maltose, para-north, sorbitol, licorice extract
  • Saccharin and its sodium salt saccharin and its sodium salt, xylitol, aspartame, sucralose, acesulfame potassium, dulcin, cyclamate, neotame, trehalose, erythritol, maltose, para-north, sorbitol, licorice extract
  • Stevia processed sweeteners thaumatin, curculin, disodium lithyrrhizinate and the like can be used. These sweeteners may
  • the pH adjuster has a function of adjusting the pH of the acidic liquid nutrient.
  • the pH adjuster is not particularly limited, and gluconic acid, succinic acid, potassium carbonate, sodium hydrogen carbonate, carbon dioxide, sodium lactate, sodium citrate, adipic acid and the like can be used. These pH adjusters may be used alone or in combination of two or more.
  • the emulsifier has a function of improving the solubility of oil-soluble components such as lipids in water. Although it does not restrict
  • the fragrance has a function of flavoring and smelling the acidic liquid nutrient.
  • the fragrance is not particularly limited, but acetophenone, ⁇ -amylcinnamaldehyde, anisaldehyde, benzaldehyde, benzyl acetate, benzyl alcohol, cinnamaldehyde, cinnamic acid, citral, citronellal, citronellol, decanal, decanol, ethyl acetoacetate, silica Ethyl cinnamate, ethyl decanoate, ethyl vanillin, eugenol, geraniol, isoamyl acetate, isoamyl butyrate, isoamyl phenyl acetate, dl-menthol, l-menthol, methyl salicylate, piperonal, propionic acid, terpineol, vanillin, d-
  • the thickener has a function of imparting an appropriate viscosity to the acidic liquid nutrient, specifically, a viscosity of 10 to 150 mPa ⁇ s at 25 ° C.
  • the thickener is not particularly limited, but agar, gelatin, pectin, guar gum, locust bean gum, konjac mannan, xanthan gum, tamarind gum, carrageenan, propylene glycol, carboxymethylcellulose gellan gum, gellan gum, tara gum, tamarind seed gum, psyllium seed Gum, gum arabic, curdlan, pullulan, sodium alginate, tragacanth gum, karaya gum, bee gum, soybean polysaccharide and the like can be used.
  • These thickeners may be used alone or in admixture of two or more. The content of the thickener in the acidic liquid nutrient is appropriately adjusted in consideration of the viscosity and the like.
  • Enzymes such as ⁇ -amylase, ⁇ -amylase, glucoamylase, glucose isomerase, trehalose producing enzyme, trehalose releasing enzyme, glutaminase, yeast and the like can be used. Content of the said food additive in an acidic liquid nutrient can be suitably adjusted with the subject etc. to apply.
  • the viscosity of the acidic liquid nutrient according to this embodiment is preferably 10 to 150 mPa ⁇ s, more preferably 20 to 120 mPa ⁇ s at 25 ° C. It is preferable that the viscosity of the acidic liquid nutrient is 150 mPa ⁇ s or less because the nasal tube can be flowed in the enteral nutrition method.
  • the viscosity can be adjusted mainly by appropriately setting the content of the stabilizer in the acidic liquid nutrient. In this specification, “viscosity” is a value measured by the method described in the examples.
  • the amount of heat of the acidic liquid nutrient according to this embodiment varies depending on the use of the acidic liquid nutrient, but is preferably 0.5 to 2.5 kcal / g, and 0.5 from the viewpoint of the safety of water management. It is more preferably from 1.0 to 1.0 kcal / g, but it is more preferably from 1.0 to 2.5 kcal / g when it is administered to a patient with water limitation or a burn patient.
  • the amount of heat can be adjusted by appropriately setting the amount of sugar, lipid, protein source, dietary fiber, and the like. In the present specification, the value calculated by the method described in the examples is adopted as the “heat amount”.
  • the pH of the acidic liquid nutrient according to this embodiment is preferably 3.0 to 4.0, and more preferably 3.5 to 3.8. A pH within the above range is preferable because the protein source can be stabilized and an effect of inhibiting bacterial growth can be obtained.
  • pH is a value measured by the method described in the examples.
  • the average particle size of the acidic liquid enteral nutrient according to this embodiment is preferably 15 ⁇ m or less, and more preferably 10 ⁇ m or less. Thus, since the average particle diameter is stabilized at 15 ⁇ m or less, the occurrence of tube clogging during administration of a nutrient can be reduced.
  • adopts the value measured by the method of the Example mentioned later.
  • the acidic liquid nutrient of the present invention can be used in a tube feeding method, particularly preferably a method of administration via a nasal tube. Administration using a nasal tube is difficult to take orally, and can be targeted for elderly people or sick people with intestinal function.
  • the acidic liquid nutrient according to the present invention contains nutrients (carbohydrate, protein source, and lipid), water, and a predetermined amount of organic acid. It is preferable to contain in the quantity which can satisfy
  • Other components that can be added are not particularly limited, and can be appropriately set according to the administration method, the condition of an elderly person or a patient to whom the acidic liquid enteral nutrient is applied, and the like. Moreover, it is preferable that the patient who needs whole body management contains the vitamin and mineral required in order to maintain a nutritional state. In order to improve constipation due to the administration of an acidic liquid enteral nutrient, it is preferable to add dietary fiber to elderly people and the like whose digestive function is lowered.
  • the acidic liquid nutrient of this form is adjusted to an appropriate viscosity and contains the necessary nutrients in a well-balanced manner, so swallowing due to elderly people whose stomach has shrunk with aging, cerebrovascular disorders, neuromuscular disorders, etc. ⁇
  • patients with impaired chewing ability patients who have difficulty in oral intake due to disturbance of consciousness, etc., for the treatment of gastrointestinal tract function, post-surgical patients, etc., for undernutrition, for prevention / treatment of reflux esophagitis, error Suitable for the prevention and treatment of aspiration pneumonia.
  • the acidic liquid nutrient according to the present invention can be produced by a known method. For example, it can be produced by adding nutrients, a predetermined amount of organic acid, and other desired components to warm water and stirring. Also, a solution in which nutrients are dissolved in warm water and a solution in which organic acids are dissolved in water are prepared, and nutrients and other desired components are added to any of them, and the two solutions are mixed and stirred. Can be manufactured.
  • the obtained acidic liquid nutrient can be commercialized by, for example, filling the container after continuous sterilization. Although it does not restrict
  • UHT Ultra high temperature short time
  • the sterilization is preferably performed in a short time. By performing sterilization in a short time, deterioration of components contained in the acidic liquid nutrient can be suppressed.
  • the container filled with the acidic liquid nutrient is not particularly limited, and a known container can be used.
  • the container include a tetrapack, a cart can, a glass container, a metal can, an aluminum pouch, and a plastic container. Of these, it is preferable to use a plastic container.
  • polyethylene polyethylene
  • PP polypropylene
  • PVC polyvinyl chloride
  • PVAc polyvinyl acetate
  • PC polycarbonate
  • PBT polybutylene terephthalate
  • PET polyethylene terephthalate
  • PEN Polyethylene naphthalate
  • EVA ethylene-vinyl acetate copolymer
  • EVA ethylene- ⁇ -olefin copolymer
  • polyfluorocarbon polyimide and the like
  • the plastic container further includes polyethylene terephthalate (PET), polyethylene naphthalate (PEN), ethylene-vinyl alcohol copolymer (EVOH), polyvinylidene chloride (PVDC), polyacrylonitrile, polyvinyl alcohol, polyamide, polyester, and the like.
  • Gas barrier resin layer Gas barrier inorganic layers such as an aluminum foil, an aluminum vapor deposition film, a silicon oxide film, and an aluminum oxide film may be used in appropriate combination. By providing the gas barrier layer, deterioration of the acidic liquid nutrient due to oxygen, water vapor, or the like can be prevented.
  • the container may be further shielded from light.
  • the light shielding for example, deterioration due to light of vitamin A, vitamin B2, vitamin C, vitamin K and the like which can be contained in the acidic liquid nutrient can be suppressed.
  • kits may be used, for example, soft pouches (manufactured by Fuji Seal Co., Ltd.), bottled pouches (manufactured by Toppan Printing Co., Ltd.), spouches (manufactured by Dai Nippon Printing Co., Ltd.), cheer packs (co., Ltd.) Hosokawa Yoko) etc. can be used.
  • Example 1 The preparation method at the time of 6000g preparation is described below.
  • the blending amount of each raw material is as shown in Table 1-1 and Table 1-2.
  • 2000 g of the prepared water was weighed and heated to 50-60 ° C. in a hot water bath.
  • Antifoaming agent (Awabreak G-109 (manufactured by Taiyo Kagaku Co., Ltd.)), whey protein (WPC392 (manufactured by Fonterra)), soy protein (Prolina (registered trademark) 900 (manufactured by Fuji Oil Co., Ltd.)), sugar Quality dextrin (TK-16 (manufactured by Matsutani Chemical Co., Ltd.)) and super white sugar were added.
  • lipid, glycerin fatty acid ester as an emulsifier, soybean polysaccharide (Soya Five-S-DN (manufactured by Fuji Oil Co., Ltd.)), and pectin were added and mixed.
  • vitamins, water-soluble vitamin mix and fat-soluble vitamin mix minerals as calcium gluconate, magnesium chloride, potassium chloride, sodium chloride, sodium dihydrogen phosphate and tripotassium citrate, yeast as yeast mix, organic acid As citric acid and malic acid, ascorbic acid, fragrance and the like were appropriately added and stirred. Water was added until the obtained mixed solution became 6000 g, and dissolved and dispersed until a uniform state was obtained.
  • the obtained solution was continuously sterilized, filled in an aluminum pouch with a stopper so as to be 200 parts per piece, and subjected to container sterilization at 90 ° C. for 10 minutes. After the container sterilization treatment, an acidic liquid nutrient containing a pouch was produced by cooling.
  • the total energy was calculated as (4 Kcal ⁇ sugar content) + (9 Kcal ⁇ lipid content) + (4 Kcal ⁇ protein source content), and the calorie was shown as Kcal per g of sample.
  • antifoaming agent (Awabreak G-109: manufactured by Taiyo Kagaku Co., Ltd.), whey protein (WPC392 (manufactured by Fonterra)), and dextrin (TK-16 (manufactured by Matsutani Chemical Co., Ltd.)
  • WPC392 manufactured by Taiyo Kagaku Co., Ltd.
  • TK-16 dextrin
  • super white sugar To the solution, lipid, glycerin fatty acid ester as an emulsifier, and soybean polysaccharide (Soya Five-S-DN (manufactured by Fuji Oil Co., Ltd.)) were added and mixed.
  • Vitamin mix and fat-soluble vitamin mix as minerals, calcium gluconate, magnesium chloride, potassium chloride, sodium chloride, sodium dihydrogen phosphate and tripotassium citrate, as yeast, yeast mix, as organic acid, citric acid, etc. Ascorbic acid, fragrance and the like were appropriately added and stirred. If liquid water was added until 6000 g, it was dissolved and dispersed into a homogeneous state.
  • the obtained solution was continuously sterilized, filled in an aluminum pouch with a stopper so as to be 200 parts per piece, and subjected to container sterilization at 90 ° C. for 10 minutes. After the container sterilization treatment, an acidic liquid nutrient containing a pouch was produced by cooling.
  • Viscosity was determined by allowing the acidic liquid nutrient to stand at 25 ° C. for 24 hours, and then rotating the B-type rotational viscometer (manufacturer: BROOKFIELD, model: DV-II + Pro, measurement conditions: rotation speed 60 rpm, measurement time 1 min, rotor 61, measurement temperature: room temperature (25 ° C.)).
  • the average particle size was measured using a laser diffraction type particle size distribution analyzer SALD7000 (Shimadzu Corporation).
  • Stability was determined by visually checking the separated state of the acidic liquid nutrient after standing the acidic liquid nutrient at room temperature for 7 days, and judging the stability of the liquid. The stability was judged according to the following evaluation criteria. ⁇ : No separation was observed in the nutrient solution, and stability was maintained. ⁇ : Slight sediment is seen on the bottom of the nutrient container. X: Clear separation is observed in the nutrient solution.
  • the amount of precipitation was measured by weighing 40 g of acidic liquid nutrient into a 50 mL falcon conical tube (Falcon), centrifuging at 3000 rpm for 10 minutes with a centrifuge Hitachi CF9RX (Hitachi), and then supernatant. And the weight of the precipitate remaining in the tube was measured.
  • ⁇ The amount of the precipitate is 2.0 g or less
  • ⁇ The amount of the precipitate is less than 4.0 g
  • the amount of the precipitate is 4.0 g or more
  • Tube fluidity is measured by measuring about 200 mL of sample with a measuring cylinder and transferring it to an enteral nutrition bottle (manufactured by Terumo Corporation). A feeding tube (manufactured by Nipro Co., Ltd.) having a length of 100 cm was connected, and the fluidity of the nutrient was evaluated at a flow rate of 300 mL / hr.
  • ⁇ There is no tube clogging and the entire amount can be flowed.
  • Tube clogging occurs within 30 minutes after the start of flow, and the entire amount cannot be flowed.
  • Viscosity is high and cannot flow through a nasal tube.
  • the nutrients of Examples 1 to 11 had a small amount of precipitation and excellent tube fluidity despite having the same viscosity as the nutrients of Comparative Examples 3 to 6. From this, it can be understood that the stability of the protein under acidic conditions is not simply caused by the addition of a stabilizer or the like, but it is important to add a predetermined amount of an organic acid.
  • the acidic liquid nutrient according to the present invention contains nutrients (sugars, protein sources and lipids), moisture, and a predetermined amount of organic acid, and is supplied via a tube feeding method, particularly via a nasal tube.
  • the present invention has industrial applicability as a nutrient that is preferably used in a method to be administered.

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Abstract

L'invention porte sur un nutriment liquide acide qui comprend un glucide, une source de protéine, un lipide et un acide organique, la proportion de l'acide organique étant de 0,15 à 0,45 partie pour une partie de la protéine. De plus, de préférence, la viscosité à 25°C est de 10 à 150 mPa·s, le pH est de 3,0 à 4,0, la taille moyenne des particules, mesurée avec un analyseur de taille de particules, est inférieure ou égale à 15 µm, la source de protéine est une protéine de lactosérum et/ou une protéine végétale et la protéine végétale est une protéine de soja. Selon la présente invention, un nutriment liquide acide dans lequel la protéine ne s'agrège pas même dans une zone acide et qui a une viscosité adéquate peut être obtenu.
PCT/JP2012/068783 2012-07-25 2012-07-25 Nutriment liquide acide WO2014016917A1 (fr)

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016158602A (ja) * 2015-03-04 2016-09-05 森永乳業株式会社 高タンパク質飲料及びその製造方法
WO2018030284A1 (fr) * 2016-08-08 2018-02-15 株式会社明治 Composition nutritionnelle sous forme de liquide acide
CN110290708A (zh) * 2017-02-28 2019-09-27 株式会社明治 含有源自乳发酵成分的蛋白质的液态营养组合物
JP2019210259A (ja) * 2018-06-08 2019-12-12 テルモ株式会社 液状栄養素補給組成物
JP2020156435A (ja) * 2019-03-28 2020-10-01 テルモ株式会社 液状栄養素補給組成物
WO2022003027A1 (fr) * 2020-07-02 2022-01-06 Fresenius Kabi Deutschland Gmbh Kit de coloration d'aliments pour alimentation par sonde

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000000077A (ja) * 1997-11-07 2000-01-07 Kyowa Hakko Kogyo Co Ltd 蛋白質含有酸性飲食品
WO2004010796A1 (fr) * 2002-07-29 2004-02-05 Otsuka Pharmaceutical Co., Ltd. Composition de boisson sous forme gelifiee

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000000077A (ja) * 1997-11-07 2000-01-07 Kyowa Hakko Kogyo Co Ltd 蛋白質含有酸性飲食品
WO2004010796A1 (fr) * 2002-07-29 2004-02-05 Otsuka Pharmaceutical Co., Ltd. Composition de boisson sous forme gelifiee

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016158602A (ja) * 2015-03-04 2016-09-05 森永乳業株式会社 高タンパク質飲料及びその製造方法
WO2018030284A1 (fr) * 2016-08-08 2018-02-15 株式会社明治 Composition nutritionnelle sous forme de liquide acide
CN109688842A (zh) * 2016-08-08 2019-04-26 株式会社明治 酸性液状营养组合物
JPWO2018030284A1 (ja) * 2016-08-08 2019-06-13 株式会社明治 酸性液状栄養組成物
JP7218987B2 (ja) 2016-08-08 2023-02-07 株式会社明治 酸性液状栄養組成物
CN110290708A (zh) * 2017-02-28 2019-09-27 株式会社明治 含有源自乳发酵成分的蛋白质的液态营养组合物
JP2019210259A (ja) * 2018-06-08 2019-12-12 テルモ株式会社 液状栄養素補給組成物
JP7171248B2 (ja) 2018-06-08 2022-11-15 テルモ株式会社 液状栄養素補給組成物
JP2020156435A (ja) * 2019-03-28 2020-10-01 テルモ株式会社 液状栄養素補給組成物
JP7176991B2 (ja) 2019-03-28 2022-11-22 テルモ株式会社 液状栄養素補給組成物
WO2022003027A1 (fr) * 2020-07-02 2022-01-06 Fresenius Kabi Deutschland Gmbh Kit de coloration d'aliments pour alimentation par sonde

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