WO2014016917A1 - Acidic liquid nutrient - Google Patents

Acidic liquid nutrient Download PDF

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Publication number
WO2014016917A1
WO2014016917A1 PCT/JP2012/068783 JP2012068783W WO2014016917A1 WO 2014016917 A1 WO2014016917 A1 WO 2014016917A1 JP 2012068783 W JP2012068783 W JP 2012068783W WO 2014016917 A1 WO2014016917 A1 WO 2014016917A1
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WIPO (PCT)
Prior art keywords
acidic liquid
liquid nutrient
protein
oil
acid
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Application number
PCT/JP2012/068783
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French (fr)
Japanese (ja)
Inventor
泰代 谷
Original Assignee
テルモ株式会社
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Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Priority to JP2014526652A priority Critical patent/JP5902815B2/en
Priority to PCT/JP2012/068783 priority patent/WO2014016917A1/en
Publication of WO2014016917A1 publication Critical patent/WO2014016917A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/011—Hydrolysed proteins; Derivatives thereof from plants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/01—Hydrolysed proteins; Derivatives thereof
    • A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
    • A61K38/018—Hydrolysed proteins; Derivatives thereof from animals from milk
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals

Definitions

  • the present invention relates to an acidic liquid nutrient.
  • Enteral nutrition is a physiological route of nutrition via the gastrointestinal tract that can solve the problems associated with high-calorie infusion methods. It is an important nutritional method for difficult patients. Liquid enteral nutrients used for enteral nutrition require that various nutrients necessary for the body (proteins, carbohydrates, lipids, minerals, vitamins, water, etc.) be included in sufficient amounts and in a well-balanced manner. In particular, the majority of the elderly are said to have protein and energy undernutrition (PEM) epilepsy and hypoproteinemia. It is important.
  • PEM protein and energy undernutrition
  • liquid enteral nutrients MPC, casein, soybean protein, and the like are used as protein raw materials, but many of the protein raw materials have an isoelectric point on the acidic side. It is. In the protein raw material, protein aggregation or precipitation occurs in the acidic region. Therefore, most of the liquid enteral nutrients currently on the market are of the neutral type with a pH of about 6.5 to 7.5.
  • enteral nutrients conventionally used may partially aggregate when the protein component comes into contact with gastric juice that is in the acidic range, which tends to cause clogging of the tube and reduce the protein content. It was difficult to increase.
  • the neutral type tends to be sweet in taste and flavor, has no refreshing flavor variations, and is difficult to ingest continuously.
  • Patent Document 1 A method for producing an acidic gel-like food is disclosed (Patent Document 1), characterized in that it is subjected to a treatment and then cooled to cause gelation.
  • acid-resistant water containing 20 to 50% by weight of fat (A), 0.5 to 5.0% by weight of whey protein (B), and 1.0 to 5.0% by weight of organic acid monogly (C) Oil-type emulsion composition.
  • a gel food comprising a gelling agent such as thickening polysaccharide or gelatin
  • the acid-resistant oil-in-water emulsion composition is blended in an amount of 5 to 40% by weight in the gel food, and the pH is 3.0.
  • Gel foods and the like characterized by adjusting to ⁇ 4.2 are disclosed (Patent Document 2).
  • Patent Documents 1 and 2 above various types of acidic-type foods and drinks containing proteins are known.
  • storage stability is improved by hardening with a gelling agent. It is a highly gelled food product, and it is difficult to say that protein aggregation is suppressed in the acidic region.
  • Patent Document 2 is a gel-like food in which organic acid monoglyceride is an essential raw material and imparts stability by increasing the viscosity, and does not improve protein aggregation itself in the acidic region. It is difficult to say that the stability of the product is satisfactory.
  • An object of the present invention is to provide an acidic liquid liquid food having high protein stability, moderate viscosity, and excellent tube fluidity even under acidic conditions.
  • the present inventor has found that the above problems can be solved by setting the blending ratio of protein and organic acid, and has completed the present invention. That is, the present invention relates to the following acidic liquid nutrient.
  • the acidic liquid nutrient of the present invention is an acidic liquid nutrient that has high stability and does not cause tube clogging even when the nutrient is administered through a tube. Therefore, it is possible to reliably and easily ingest nutrition without the need for readjustment of the flow rate during nursing care.
  • the acidic liquid nutrient suitable for the enteral nutrition method of the present invention is characterized in that a carbohydrate, a protein source, a lipid, and a predetermined amount of an organic acid are blended in the nutrient.
  • the acidic liquid nutrient contains a sugar, a protein source, a lipid, and a predetermined amount of an organic acid.
  • Organic acid is not particularly limited, and acetic acid, citric acid, succinic acid, lactic acid, malic acid, tartaric acid, gluconic acid and the like can be used. These acidulants may be used alone or in combination of two or more.
  • the blending ratio of the organic acid in the acidic liquid nutrient is preferably 0.15 to 0.45 part, more preferably 0.19 to 0.40 part with respect to 1 part of the protein source.
  • Nutrients preferably include carbohydrates, protein sources, and lipids.
  • the nutrient may further contain at least one selected from the group consisting of vitamins, minerals, and dietary fiber as an optional component.
  • the total amount of nutrients in the acidic liquid nutrient is preferably 8 to 60% by mass, and more preferably 15 to 40% by mass.
  • Carbohydrates are also called carbohydrates and serve as energy sources.
  • the carbohydrate is not particularly limited as long as it is absorbed into the living body and becomes an energy source, and examples thereof include monosaccharides, disaccharides, and polysaccharides.
  • Specific examples of monosaccharides include glucose (glucose), fructose (fructose), galactose and the like.
  • Specific examples of the disaccharide include sucrose (sucrose), lactose (lactose), maltose (malt sugar), isomaltose, trehalose and the like.
  • Specific examples of the polysaccharide include starch (amylose, amylopectin), dextrin and the like. Of these, dextrin is preferably used.
  • Dextrin is a general term for substances in which several ⁇ -glucoses are polymerized by glycosidic bonds, and can be obtained by hydrolysis of starch. Since dextrin has a slow degradation rate in the small intestine and is slowly absorbed, it can prevent a rapid increase in blood sugar. Further, by using dextrin, the osmotic pressure of the acidic liquid nutrient can be reduced, and osmotic diarrhea can be prevented.
  • the dextrin either a high molecular dextrin having a high degree of polymerization of ⁇ -glucose or a low molecular dextrin having a low degree of polymerization of ⁇ -glucose may be used, but a high molecular dextrin capable of further reducing the osmotic pressure should be used. Is preferred.
  • the low molecular dextrin is also called maltodextrin and is usually a polymer of 3 to 5 ⁇ -glucose.
  • Dextrin may be prepared by itself or a commercially available product may be used.
  • known starches such as corn, waxy corn, wheat, rice, waxy rice, waxy miro, beans (broad beans, mung beans, red beans, etc.), potatoes, sweet potatoes, tapioca, etc. It can be prepared by hydrolysis by a known method.
  • examples of commercially available dextrin include TK-16 (manufactured by Matsutani Chemical Industry Co., Ltd.) and the like, which can be preferably used.
  • the above saccharides may be used alone or in admixture of two or more.
  • the content of the saccharide in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied, but is preferably 5 to 30% by mass with respect to the total amount of the acidic liquid nutrient.
  • the protein source is not particularly limited, and known proteins can be used.
  • Amino acids include essential amino acids such as valine, leucine, isoleucine, lysine, methionine, phenylalanine, threonine, tryptophan, histidine; and glycine, alanine, serine, cysteine, asparagine, glutamine, proline, tyrosine, aspartic acid, glutamic acid, arginine, etc. Of the non-essential amino acids.
  • modified amino acids such as 4-hydroxyproline, 5-hydroxylysine, ⁇ -carboxyglutamic acid, O-phosphoserine, O-phosphotyrosine, N-acetylserine, N ⁇ -methylarginine, pyroglutamic acid, M-formylmethionine; Special amino acids such as ornithine, citrulline, ⁇ -aminobutyric acid (GABA), thyroxine, S-adenylmethionine can also be included.
  • the amino acids may be stereoisomers (enantiomers, diastereomers), positional isomers, or a mixture thereof.
  • the amino acid may be in the form of an inorganic acid salt (hydrochloride or the like), an organic acid salt (acetate or the like), or an ester body (methyl ester or the like) that can be hydrolyzed in vivo.
  • plant proteins examples include proteins contained in grains such as rice and beans such as soybeans and tofu.
  • the soy protein may have a health function such as binding to bile acid to promote cholesterol excretion.
  • whey protein and soybean protein made from milk (whey) as raw materials, and more preferably whey protein.
  • whey proteins include whey protein concentrate (WPC), whey protein isolate (WPI), and hydrolyzed whey peptide (WPH).
  • WPC, WPI, soybean protein, and the like may be commercially available.
  • WPC392 manufactured by Fonterra
  • WPC80 manufactured by Fontera
  • soy protein Prolina (registered trademark) 900 (registered trademark) Fuji Oil Co., Ltd.), Prolina (registered trademark) 300 (Fuji Oil Co., Ltd.) and the like.
  • the above protein source, amino acid or peptide may be used alone or in combination of two or more.
  • the content of the protein source in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied, but is preferably 2 to 15% by mass with respect to the total amount of the acidic liquid nutrient.
  • Lipids can be a source of energy, biomembrane constituents, steroid hormones and bile acids.
  • the lipid is not particularly limited, and examples thereof include saturated fatty acids, unsaturated fatty acids, vegetable oils, animal fats and oils, and fish oils.
  • saturated fatty acids examples include caprylic acid, capric acid, lauric acid, palmitic acid, stearic acid and the like.
  • unsaturated fatty acids include oleic acid, palmitoleic acid, linoleic acid, arachidonic acid, ⁇ -linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
  • EPA and DHA it can have functions, such as a blood cholesterol raise inhibitory effect and a neutral fat rise inhibitory effect.
  • Vegetable oils include coconut oil, corn oil, cottonseed oil, olive oil, palm oil, palm kernel oil, peanut oil, rapeseed oil, safflower oil (safflower oil), sesame oil, soybean oil, sunflower oil, almond oil, cashew oil, hazelnut Oil, macadamia nut oil, mongolian oil, pecan oil, pine nut oil, pistachio oil, walnut oil, gourd seed oil, buffalo pumpkin oil, pumpkin seed oil, watermelon seed oil, amaranth oil, apricot oil, apple oil, argan oil , avocado oil, babas oil, moringa oil, borneo oil, cape chestnut oil, cocoa butter, carob oil, kofne palm oil, coriander seed oil, dica oil, flaxseed oil, grape seed oil, hemp oil, kapok seed oil, lale mantia oil , Marula oil, Meadow foam oil, mustard oil, Tsumug butter, okra oil, papaya oil, perilla oil
  • Animal fats include lard (pig fat), head (tallow), milk fat, and the like.
  • Fish oil includes fish oil such as mackerel, salmon, yellowtail, sardine, saury.
  • linoleic acid and ⁇ -linolenic acid that cannot be synthesized in vivo by humans, or lipids containing these.
  • the above lipids may be used alone or in combination of two or more.
  • the lipid content in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied, but is preferably 1 to 8% by mass with respect to the total amount of the acidic liquid nutrient.
  • Vitamins are a general term for organic compounds other than carbohydrates, amino acids or peptides, and lipids that are necessary for maintaining the nutritional state of organisms.
  • Vitamin A retinol
  • vitamin D ergocalciferol, cholecalciferol
  • vitamin E tocopherol, tocotrienol
  • vitamin K phytoquinone, menaquinone
  • vitamin B1 thiamine
  • vitamin B2 Roboflavin
  • vitamin B3 niacin
  • vitamin B5 pantothenic acid
  • vitamin B6 pyridoxal, pyridoxamine, pyridoxine
  • vitamin B7 biotin
  • vitamin B9 folic acid
  • vitamin B12 cyanocobalamin, hydroxocobalamin
  • vitamin C water-soluble vitamins such as (ascorbic acid). These vitamins may be used alone or in combination of two or more.
  • the content of vitamins in the acidic liquid nutrient can be adjusted as appropriate by the subject to be applied. Normally, fat-soluble vitamins are added in an amount that does not cause excess disease, and water-soluble vitamins are not limited in the amount added.
  • the preferable content of each vitamin per 100 g of acidic liquid nutrient is as follows.
  • Fat-soluble vitamin Vitamin A preferably 0 to 3000 ⁇ g, more preferably 20 to 200 ⁇ g Vitamin D: preferably 0.1-50 ⁇ g, more preferably 0.1-5.0 ⁇ g Vitamin E: preferably 0.2 to 800 mg, more preferably 1 to 10 mg Vitamin K: preferably 0.5 to 1000 ⁇ g, more preferably 2 to 50 ⁇ g
  • Water-soluble vitamin Vitamin B1 preferably 0.01 to 40 mg, more preferably 0.1 to 10 mg Vitamin B2: preferably 0.01-20 mg, more preferably 0.05-10 mg Niacin: preferably 0.1 to 300 mg NE, more preferably 0.5 to 60 mg NE Pantothenic acid: preferably 0.1 to 55 mg, more preferably 0.2 to 30 mg Vitamin B6: preferably 0.01-60 mg, more preferably 0.1-30 mg Biotin: preferably 0.1 to 1000 ⁇ g, more preferably 1 to 100 ⁇ g Folic acid: preferably 1-1000 ⁇ g, more preferably 10-200 ⁇ g Vitamin B12: preferably 0.01-100 ⁇ g, more preferably 0.2-60 ⁇ g Vitamin C: preferably 1-2000 mg, more preferably 5-1000 mg
  • Minerals are elements other than organic compounds that are necessary for maintaining the nutritional state of living organisms.
  • Examples of the mineral include quasi-major elements such as sodium, potassium, calcium, phosphorus and magnesium; essential trace elements such as iron, zinc, copper, iodine, manganese, selenium, chromium and molybdenum. These minerals may be used alone or in combination of two or more.
  • the content of mineral in the acidic liquid nutrient can be adjusted as appropriate by the subject to be applied.
  • the preferable content of each mineral per 100 g of acidic liquid nutrient is as follows.
  • Semi-major element sodium preferably 5 to 6000 mg, more preferably 10 to 3500 mg Potassium: preferably 1 to 3500 mg, more preferably 25 to 1800 mg Calcium: preferably 10-2300 mg, more preferably 30-300 mg Phosphorus: preferably 1 to 3500 mg, more preferably 25 to 1500 mg Magnesium: preferably 1 to 740 mg, more preferably 10 to 150 mg
  • Essential trace element Iron preferably 0.1 to 55 mg, more preferably 1 to 10 mg Zinc: preferably 0.1-30 mg, more preferably 1-15 mg Copper: preferably 0.01 to 10 mg, more preferably 0.06 to 6 mg Iodine: preferably 0.1 to 3000 ⁇ g, more preferably 1 to 150 ⁇ g Manganese: preferably 0.01 to 11 mg, more preferably 0.1 to 4 mg Selenium: preferably 0.1 to 450 ⁇ g, more preferably 1 to 35 ⁇ g Chromium: preferably 0.1 to 40 ⁇ g, more preferably 1 to 35 ⁇ g Molybdenum: preferably 0.1 to 320 ⁇ g, more preferably 1 to 25 ⁇ g
  • Dietary fiber can have functions such as reduced nutrient utilization, reduced plasma cholesterol, improved blood glucose response, improved colon function, and prevention of colon cancer.
  • dietary fiber may be fermented by intestinal bacteria and converted to short chain fatty acids, carbon dioxide gas, hydrogen gas, methane gas, and the like. Among these, since short chain fatty acids are absorbed in the large intestine, dietary fiber may be an energy source.
  • the dietary fiber is not particularly limited, but is insoluble dietary fiber such as cellulose, hemicellulose, lignin, insoluble pectin, chitin, chitosan, psyllium seed, low molecular weight sodium alginate; water-soluble pectin, guar gum, konjac mannan, glucomannan, alginic acid , Agar, chemically modified polysaccharide, polydextrose, indigestible oligosaccharide, maltitol, inulin, carrageenan, wheat bran, indigestible dextrin (eg, Pine Fiber C (manufactured by Matsutani Chemical Co., Ltd.), polydextrose, guar gum decomposition And water-soluble dietary fiber such as food.
  • insoluble dietary fiber such as cellulose, hemicellulose, lignin, insoluble pectin, chitin, chitosan, psyllium seed, low molecular weight sodium
  • dietary fibers may be used alone or in combination of two or more.
  • the content of dietary fiber in the acidic liquid nutrient can be adjusted as appropriate by the subject to be applied.
  • the acidic liquid nutrient according to the present invention preferably contains moisture.
  • the water content in the acidic liquid nutrient can be adjusted as appropriate depending on the subject to be applied, the desired viscosity, etc., but is preferably 30 to 90% by mass with respect to the total amount of the acidic liquid nutrient. From the viewpoint of the above, it is more preferably 50 to 90% by mass.
  • the acidic liquid nutrient according to the present embodiment may further contain other known components such as the following components.
  • a health function component is a component that exhibits a certain function for a living body when ingested.
  • resistant oligosaccharide sugar alcohol, calcium citrate malate (CCM) and casein phosphopeptide (CPP), chitosan, L-arabinose, guava leaf polyphenol, wheat albumin, bean extract, diacylglycerol, diacylglycerol plant Sterols, soy isoflavones, milk basic proteins and the like.
  • the indigestible oligosaccharide is a saccharide whose molecular weight is not as large as that of a polysaccharide (about 300 to 3,000) among compounds in which monosaccharides are bound by glycosidic bonds.
  • the indigestible oligosaccharides are not degraded by human digestive enzymes, but those digested by human digestive enzymes can be included in the above-mentioned carbohydrates. Ingestion of indigestible oligosaccharides can provide a bowel regulation effect.
  • the indigestible oligosaccharide is not particularly limited, and examples thereof include xylooligosaccharide, fructooligosaccharide, soybean oligosaccharide, isomaltooligosaccharide, dairy oligosaccharide, lactulose, and galactooligosaccharide. These indigestible oligosaccharides may be used alone or in combination of two or more. The content of the indigestible oligosaccharide in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.
  • Sugar alcohol is a kind of sugar produced by reducing the carbonyl group of aldose or ketose, and is poorly absorbed from the small intestine into the body and is not easily caloric. Sugar alcohol is difficult to be metabolized to acid by oral bacteria and can prevent plaque formation. The sugar alcohol can be used as a low calorie sweetener.
  • sugar alcohols examples include erythritol, maltitol, palatinose and the like. These sugar alcohols may be used alone or in admixture of two or more.
  • the content of the sugar alcohol in the acidic liquid nutrient can be adjusted as appropriate by the subject to be applied.
  • CCM and CPP can promote calcium absorption and promote bone formation.
  • the CCM and CPP may be used alone or in combination.
  • CCM and CPP are preferably used in combination with calcium.
  • the contents of CCM and CPP in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.
  • Food additive The food additive is used for the purpose of processing or storing the food by adding, mixing, moistening or other methods to the food.
  • food additives for example, zinc gluconate and copper gluconate, ascorbic acid 2-glucoside, cyclodextrin, preservatives, fungicides, antioxidants, coloring agents, sweeteners, A pH adjuster, a sour agent, an emulsifier, a fragrance
  • Zinc gluconate and copper gluconate are gluconates utilizing high chelating ability of gluconic acid with heavy metal ions. Since it becomes easy to be absorbed when it is made into the form of gluconate, zinc and copper can be absorbed effectively.
  • the zinc gluconate and copper gluconate may be used alone or in combination.
  • the content of zinc gluconate and copper gluconate in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.
  • Ascorbic acid 2-glucoside is a compound in which glucose is ⁇ -coordinated to the hydroxyl group at the 2-position of vitamin C (ascorbic acid) and is more stable than normal vitamin C because it is not attacked by oxygen. C derivative. Vitamin C can be efficiently absorbed by ascorbic acid 2-glucoside. The content of ascorbic acid 2-glucoside in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.
  • Cyclodextrin is a cyclic oligosaccharide having a cyclic structure in which glucose is bound by a glucoside bond. Those consisting of 6 glucoses are called ⁇ -cyclodextrin, those consisting of 7 glucoses are called ⁇ -cyclodextrin, and those consisting of 8 glucoses are called ⁇ -cyclodextrin. Cyclodextrins can have functions such as an allergy suppressing effect, a blood sugar level increase suppressing effect, and an emulsifying action. The said cyclodextrin may be used independently or may be used in mixture of 2 or more types. The content of cyclodextrin in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.
  • the antioxidant has a function of preventing deterioration of the acidic liquid nutrient due to oxidation. Although it does not restrict
  • the colorant has a function of beautifying the acidic liquid nutrient. Although it does not restrict
  • dye Edible red No. 2, No. 3, No. 40, No. 102, No. 104, No. 105, and No. 106, Edible blue No. 1 and No. 2, Edible yellow No. 4 And No. 5, Edible Green No.
  • ⁇ -carotene water-soluble anato, chlorophyll derivatives (chlorophyll a, chlorphyll b, copper chlorophyll, copper chlorophyllin sodium, iron chlorophyllin sodium, etc.), riboflavin, iron sesquioxide, titanium dioxide Safflower yellow pigment, cochineal pigment, gardenia yellow pigment, turmeric pigment, red cabbage pigment, beet red, grape skin pigment, paprika pigment, caramel and the like can be used. These colorants may be used alone or in admixture of two or more.
  • the sweetener has a function of imparting sweetness to the acidic liquid nutrient.
  • the sweetener is not particularly limited, but saccharin and its sodium salt, xylitol, aspartame, sucralose, acesulfame potassium, dulcin, cyclamate, neotame, trehalose, erythritol, maltose, para-north, sorbitol, licorice extract
  • Saccharin and its sodium salt saccharin and its sodium salt, xylitol, aspartame, sucralose, acesulfame potassium, dulcin, cyclamate, neotame, trehalose, erythritol, maltose, para-north, sorbitol, licorice extract
  • Stevia processed sweeteners thaumatin, curculin, disodium lithyrrhizinate and the like can be used. These sweeteners may
  • the pH adjuster has a function of adjusting the pH of the acidic liquid nutrient.
  • the pH adjuster is not particularly limited, and gluconic acid, succinic acid, potassium carbonate, sodium hydrogen carbonate, carbon dioxide, sodium lactate, sodium citrate, adipic acid and the like can be used. These pH adjusters may be used alone or in combination of two or more.
  • the emulsifier has a function of improving the solubility of oil-soluble components such as lipids in water. Although it does not restrict
  • the fragrance has a function of flavoring and smelling the acidic liquid nutrient.
  • the fragrance is not particularly limited, but acetophenone, ⁇ -amylcinnamaldehyde, anisaldehyde, benzaldehyde, benzyl acetate, benzyl alcohol, cinnamaldehyde, cinnamic acid, citral, citronellal, citronellol, decanal, decanol, ethyl acetoacetate, silica Ethyl cinnamate, ethyl decanoate, ethyl vanillin, eugenol, geraniol, isoamyl acetate, isoamyl butyrate, isoamyl phenyl acetate, dl-menthol, l-menthol, methyl salicylate, piperonal, propionic acid, terpineol, vanillin, d-
  • the thickener has a function of imparting an appropriate viscosity to the acidic liquid nutrient, specifically, a viscosity of 10 to 150 mPa ⁇ s at 25 ° C.
  • the thickener is not particularly limited, but agar, gelatin, pectin, guar gum, locust bean gum, konjac mannan, xanthan gum, tamarind gum, carrageenan, propylene glycol, carboxymethylcellulose gellan gum, gellan gum, tara gum, tamarind seed gum, psyllium seed Gum, gum arabic, curdlan, pullulan, sodium alginate, tragacanth gum, karaya gum, bee gum, soybean polysaccharide and the like can be used.
  • These thickeners may be used alone or in admixture of two or more. The content of the thickener in the acidic liquid nutrient is appropriately adjusted in consideration of the viscosity and the like.
  • Enzymes such as ⁇ -amylase, ⁇ -amylase, glucoamylase, glucose isomerase, trehalose producing enzyme, trehalose releasing enzyme, glutaminase, yeast and the like can be used. Content of the said food additive in an acidic liquid nutrient can be suitably adjusted with the subject etc. to apply.
  • the viscosity of the acidic liquid nutrient according to this embodiment is preferably 10 to 150 mPa ⁇ s, more preferably 20 to 120 mPa ⁇ s at 25 ° C. It is preferable that the viscosity of the acidic liquid nutrient is 150 mPa ⁇ s or less because the nasal tube can be flowed in the enteral nutrition method.
  • the viscosity can be adjusted mainly by appropriately setting the content of the stabilizer in the acidic liquid nutrient. In this specification, “viscosity” is a value measured by the method described in the examples.
  • the amount of heat of the acidic liquid nutrient according to this embodiment varies depending on the use of the acidic liquid nutrient, but is preferably 0.5 to 2.5 kcal / g, and 0.5 from the viewpoint of the safety of water management. It is more preferably from 1.0 to 1.0 kcal / g, but it is more preferably from 1.0 to 2.5 kcal / g when it is administered to a patient with water limitation or a burn patient.
  • the amount of heat can be adjusted by appropriately setting the amount of sugar, lipid, protein source, dietary fiber, and the like. In the present specification, the value calculated by the method described in the examples is adopted as the “heat amount”.
  • the pH of the acidic liquid nutrient according to this embodiment is preferably 3.0 to 4.0, and more preferably 3.5 to 3.8. A pH within the above range is preferable because the protein source can be stabilized and an effect of inhibiting bacterial growth can be obtained.
  • pH is a value measured by the method described in the examples.
  • the average particle size of the acidic liquid enteral nutrient according to this embodiment is preferably 15 ⁇ m or less, and more preferably 10 ⁇ m or less. Thus, since the average particle diameter is stabilized at 15 ⁇ m or less, the occurrence of tube clogging during administration of a nutrient can be reduced.
  • adopts the value measured by the method of the Example mentioned later.
  • the acidic liquid nutrient of the present invention can be used in a tube feeding method, particularly preferably a method of administration via a nasal tube. Administration using a nasal tube is difficult to take orally, and can be targeted for elderly people or sick people with intestinal function.
  • the acidic liquid nutrient according to the present invention contains nutrients (carbohydrate, protein source, and lipid), water, and a predetermined amount of organic acid. It is preferable to contain in the quantity which can satisfy
  • Other components that can be added are not particularly limited, and can be appropriately set according to the administration method, the condition of an elderly person or a patient to whom the acidic liquid enteral nutrient is applied, and the like. Moreover, it is preferable that the patient who needs whole body management contains the vitamin and mineral required in order to maintain a nutritional state. In order to improve constipation due to the administration of an acidic liquid enteral nutrient, it is preferable to add dietary fiber to elderly people and the like whose digestive function is lowered.
  • the acidic liquid nutrient of this form is adjusted to an appropriate viscosity and contains the necessary nutrients in a well-balanced manner, so swallowing due to elderly people whose stomach has shrunk with aging, cerebrovascular disorders, neuromuscular disorders, etc. ⁇
  • patients with impaired chewing ability patients who have difficulty in oral intake due to disturbance of consciousness, etc., for the treatment of gastrointestinal tract function, post-surgical patients, etc., for undernutrition, for prevention / treatment of reflux esophagitis, error Suitable for the prevention and treatment of aspiration pneumonia.
  • the acidic liquid nutrient according to the present invention can be produced by a known method. For example, it can be produced by adding nutrients, a predetermined amount of organic acid, and other desired components to warm water and stirring. Also, a solution in which nutrients are dissolved in warm water and a solution in which organic acids are dissolved in water are prepared, and nutrients and other desired components are added to any of them, and the two solutions are mixed and stirred. Can be manufactured.
  • the obtained acidic liquid nutrient can be commercialized by, for example, filling the container after continuous sterilization. Although it does not restrict
  • UHT Ultra high temperature short time
  • the sterilization is preferably performed in a short time. By performing sterilization in a short time, deterioration of components contained in the acidic liquid nutrient can be suppressed.
  • the container filled with the acidic liquid nutrient is not particularly limited, and a known container can be used.
  • the container include a tetrapack, a cart can, a glass container, a metal can, an aluminum pouch, and a plastic container. Of these, it is preferable to use a plastic container.
  • polyethylene polyethylene
  • PP polypropylene
  • PVC polyvinyl chloride
  • PVAc polyvinyl acetate
  • PC polycarbonate
  • PBT polybutylene terephthalate
  • PET polyethylene terephthalate
  • PEN Polyethylene naphthalate
  • EVA ethylene-vinyl acetate copolymer
  • EVA ethylene- ⁇ -olefin copolymer
  • polyfluorocarbon polyimide and the like
  • the plastic container further includes polyethylene terephthalate (PET), polyethylene naphthalate (PEN), ethylene-vinyl alcohol copolymer (EVOH), polyvinylidene chloride (PVDC), polyacrylonitrile, polyvinyl alcohol, polyamide, polyester, and the like.
  • Gas barrier resin layer Gas barrier inorganic layers such as an aluminum foil, an aluminum vapor deposition film, a silicon oxide film, and an aluminum oxide film may be used in appropriate combination. By providing the gas barrier layer, deterioration of the acidic liquid nutrient due to oxygen, water vapor, or the like can be prevented.
  • the container may be further shielded from light.
  • the light shielding for example, deterioration due to light of vitamin A, vitamin B2, vitamin C, vitamin K and the like which can be contained in the acidic liquid nutrient can be suppressed.
  • kits may be used, for example, soft pouches (manufactured by Fuji Seal Co., Ltd.), bottled pouches (manufactured by Toppan Printing Co., Ltd.), spouches (manufactured by Dai Nippon Printing Co., Ltd.), cheer packs (co., Ltd.) Hosokawa Yoko) etc. can be used.
  • Example 1 The preparation method at the time of 6000g preparation is described below.
  • the blending amount of each raw material is as shown in Table 1-1 and Table 1-2.
  • 2000 g of the prepared water was weighed and heated to 50-60 ° C. in a hot water bath.
  • Antifoaming agent (Awabreak G-109 (manufactured by Taiyo Kagaku Co., Ltd.)), whey protein (WPC392 (manufactured by Fonterra)), soy protein (Prolina (registered trademark) 900 (manufactured by Fuji Oil Co., Ltd.)), sugar Quality dextrin (TK-16 (manufactured by Matsutani Chemical Co., Ltd.)) and super white sugar were added.
  • lipid, glycerin fatty acid ester as an emulsifier, soybean polysaccharide (Soya Five-S-DN (manufactured by Fuji Oil Co., Ltd.)), and pectin were added and mixed.
  • vitamins, water-soluble vitamin mix and fat-soluble vitamin mix minerals as calcium gluconate, magnesium chloride, potassium chloride, sodium chloride, sodium dihydrogen phosphate and tripotassium citrate, yeast as yeast mix, organic acid As citric acid and malic acid, ascorbic acid, fragrance and the like were appropriately added and stirred. Water was added until the obtained mixed solution became 6000 g, and dissolved and dispersed until a uniform state was obtained.
  • the obtained solution was continuously sterilized, filled in an aluminum pouch with a stopper so as to be 200 parts per piece, and subjected to container sterilization at 90 ° C. for 10 minutes. After the container sterilization treatment, an acidic liquid nutrient containing a pouch was produced by cooling.
  • the total energy was calculated as (4 Kcal ⁇ sugar content) + (9 Kcal ⁇ lipid content) + (4 Kcal ⁇ protein source content), and the calorie was shown as Kcal per g of sample.
  • antifoaming agent (Awabreak G-109: manufactured by Taiyo Kagaku Co., Ltd.), whey protein (WPC392 (manufactured by Fonterra)), and dextrin (TK-16 (manufactured by Matsutani Chemical Co., Ltd.)
  • WPC392 manufactured by Taiyo Kagaku Co., Ltd.
  • TK-16 dextrin
  • super white sugar To the solution, lipid, glycerin fatty acid ester as an emulsifier, and soybean polysaccharide (Soya Five-S-DN (manufactured by Fuji Oil Co., Ltd.)) were added and mixed.
  • Vitamin mix and fat-soluble vitamin mix as minerals, calcium gluconate, magnesium chloride, potassium chloride, sodium chloride, sodium dihydrogen phosphate and tripotassium citrate, as yeast, yeast mix, as organic acid, citric acid, etc. Ascorbic acid, fragrance and the like were appropriately added and stirred. If liquid water was added until 6000 g, it was dissolved and dispersed into a homogeneous state.
  • the obtained solution was continuously sterilized, filled in an aluminum pouch with a stopper so as to be 200 parts per piece, and subjected to container sterilization at 90 ° C. for 10 minutes. After the container sterilization treatment, an acidic liquid nutrient containing a pouch was produced by cooling.
  • Viscosity was determined by allowing the acidic liquid nutrient to stand at 25 ° C. for 24 hours, and then rotating the B-type rotational viscometer (manufacturer: BROOKFIELD, model: DV-II + Pro, measurement conditions: rotation speed 60 rpm, measurement time 1 min, rotor 61, measurement temperature: room temperature (25 ° C.)).
  • the average particle size was measured using a laser diffraction type particle size distribution analyzer SALD7000 (Shimadzu Corporation).
  • Stability was determined by visually checking the separated state of the acidic liquid nutrient after standing the acidic liquid nutrient at room temperature for 7 days, and judging the stability of the liquid. The stability was judged according to the following evaluation criteria. ⁇ : No separation was observed in the nutrient solution, and stability was maintained. ⁇ : Slight sediment is seen on the bottom of the nutrient container. X: Clear separation is observed in the nutrient solution.
  • the amount of precipitation was measured by weighing 40 g of acidic liquid nutrient into a 50 mL falcon conical tube (Falcon), centrifuging at 3000 rpm for 10 minutes with a centrifuge Hitachi CF9RX (Hitachi), and then supernatant. And the weight of the precipitate remaining in the tube was measured.
  • ⁇ The amount of the precipitate is 2.0 g or less
  • ⁇ The amount of the precipitate is less than 4.0 g
  • the amount of the precipitate is 4.0 g or more
  • Tube fluidity is measured by measuring about 200 mL of sample with a measuring cylinder and transferring it to an enteral nutrition bottle (manufactured by Terumo Corporation). A feeding tube (manufactured by Nipro Co., Ltd.) having a length of 100 cm was connected, and the fluidity of the nutrient was evaluated at a flow rate of 300 mL / hr.
  • ⁇ There is no tube clogging and the entire amount can be flowed.
  • Tube clogging occurs within 30 minutes after the start of flow, and the entire amount cannot be flowed.
  • Viscosity is high and cannot flow through a nasal tube.
  • the nutrients of Examples 1 to 11 had a small amount of precipitation and excellent tube fluidity despite having the same viscosity as the nutrients of Comparative Examples 3 to 6. From this, it can be understood that the stability of the protein under acidic conditions is not simply caused by the addition of a stabilizer or the like, but it is important to add a predetermined amount of an organic acid.
  • the acidic liquid nutrient according to the present invention contains nutrients (sugars, protein sources and lipids), moisture, and a predetermined amount of organic acid, and is supplied via a tube feeding method, particularly via a nasal tube.
  • the present invention has industrial applicability as a nutrient that is preferably used in a method to be administered.

Abstract

Provided is an acidic liquid nutrient which comprises a carbohydrate, a protein source, a lipid and an organic acid, wherein the proportion of the organic acid is 0.15 to 0.45 parts with respect to one part of the protein. In addition, preferably, the viscosity at 25° is 10 to 150 mPa·s, pH is 3.0 to 4.0, the average particle size when measured with a particle size analyzer is 15 μm or less, the protein source is a whey protein and/or a vegetable protein, and the vegetable protein is a soy protein. According to the present invention, an acidic liquid nutrient in which the protein does not aggregate even in an acidic region and which has an adequate viscosity can be provided.

Description

酸性液状栄養剤Acid liquid nutrient
　本発明は、酸性液状栄養剤に関する。 The present invention relates to an acidic liquid nutrient.
　経腸栄養法は、消化管を経由する生理的な栄養投与経路であり、高カロリー輸液法の問題点を解決できるため、咀嚼・嚥下機能の著しい低下や意識障害などによって、食物の経口摂取が困難な患者向けの重要な栄養投与法である。経腸栄養法に用いられる液状の経腸栄養剤は、体に必要な各種の栄養素（蛋白質、糖質、脂質、ミネラル、ビタミン、水分等）が十分量、バランスよく配合されていることが求められており、特に、高齢者の大半は、タンパク・エネルギー低栄養状態（ＰＥＭ） や、低蛋白血症等にあるといわれているだけに、経腸栄養剤による各種栄養、特に蛋白質の補給が重要となっている。 Enteral nutrition is a physiological route of nutrition via the gastrointestinal tract that can solve the problems associated with high-calorie infusion methods. It is an important nutritional method for difficult patients. Liquid enteral nutrients used for enteral nutrition require that various nutrients necessary for the body (proteins, carbohydrates, lipids, minerals, vitamins, water, etc.) be included in sufficient amounts and in a well-balanced manner. In particular, the majority of the elderly are said to have protein and energy undernutrition (PEM) epilepsy and hypoproteinemia. It is important.
　ここで、一般的な液状経腸栄養剤には、蛋白質の原料として、ＭＰＣや、カゼイン、大豆蛋白質等が使用されているが、蛋白質の原料の多くは、酸性側に等電点を有するものである。こうした蛋白質原料は、酸性域では、蛋白質は凝集や、沈殿等が生じてしまう。そのため、現在、市場に出回っている液状経腸栄養剤の多くはｐＨ６．５～７．５程度の中性タイプのものである。 Here, in general liquid enteral nutrients, MPC, casein, soybean protein, and the like are used as protein raw materials, but many of the protein raw materials have an isoelectric point on the acidic side. It is. In the protein raw material, protein aggregation or precipitation occurs in the acidic region. Therefore, most of the liquid enteral nutrients currently on the market are of the neutral type with a pH of about 6.5 to 7.5.
　このような、従来から使用されている経腸栄養剤は、蛋白質成分が酸性域である胃液と接触した際、部分的に凝集することがあり、これによりチューブ詰まりが生じやすく、蛋白質含有量を増加させることが困難であった。 Such enteral nutrients conventionally used may partially aggregate when the protein component comes into contact with gastric juice that is in the acidic range, which tends to cause clogging of the tube and reduce the protein content. It was difficult to increase.
　また、中性領域では、増殖できる微生物の種類が多いため、細菌汚染等のリスクが高く、長期の保存に適しにくいものであった。更にまた、中性タイプのものは、味や風味が甘くなりがちであり、さっぱりとした風味のバリエーションがなく、継続的に摂取し難いものであった。 Also, in the neutral region, since there are many types of microorganisms that can proliferate, there is a high risk of bacterial contamination and it is difficult to be suitable for long-term storage. Furthermore, the neutral type tends to be sweet in taste and flavor, has no refreshing flavor variations, and is difficult to ingest continuously.
　酸性下でも蛋白質を安定して分散させる方法としては、従来種々の方法が検討されてきた。例えば、カゼイン蛋白質、熱可逆性ゲル化剤、および有機酸モノグリセリドを含有し、ｐＨが３．５～４．５である液状原料組成物と、水分含有固形物を容器内に充填した後、加熱処理を施し、しかる後に冷却処理してゲル化させることを特徴とする酸性ゲル状食品の製造方法が開示されている（特許文献１）。 Various methods have been studied in the past as methods for stably dispersing proteins even under acidic conditions. For example, a liquid raw material composition containing a casein protein, a thermoreversible gelling agent, and an organic acid monoglyceride and having a pH of 3.5 to 4.5 and a water-containing solid are filled in a container, and then heated. A method for producing an acidic gel-like food is disclosed (Patent Document 1), characterized in that it is subjected to a treatment and then cooled to cause gelation.
　また、油脂（Ａ）２０～５０重量％、ホエイ蛋白質（Ｂ）０．５～５．０重量％、有機酸モノグリ（Ｃ）１．０～５．０重量％を主成分とする耐酸性水中油型乳化組成物。さらに増粘多糖類、ゼラチン等のゲル化剤を配合してなるゲル状食品において、前記の耐酸性水中油型乳化組成物をゲル状食品中５～４０重量％配合し、ｐＨを３．０～４．２に調整することを特徴とするゲル状食品などが開示されている（特許文献２）。 In addition, acid-resistant water containing 20 to 50% by weight of fat (A), 0.5 to 5.0% by weight of whey protein (B), and 1.0 to 5.0% by weight of organic acid monogly (C) Oil-type emulsion composition. Furthermore, in a gel food comprising a gelling agent such as thickening polysaccharide or gelatin, the acid-resistant oil-in-water emulsion composition is blended in an amount of 5 to 40% by weight in the gel food, and the pH is 3.0. Gel foods and the like characterized by adjusting to ˜4.2 are disclosed (Patent Document 2).
特開２００７－０４９９４８JP2007-049948A 特開２００４－２９０１２０JP 2004-290120 A
　上記特許文献１および２に開示されているように、蛋白質を含有する酸性タイプの飲食品には種々のものが知られているが、特許文献１ではゲル化剤で固めることで保存安定性を高めているゲル状食品であって、酸性域での蛋白質の凝集が抑えられているとはいい難い。 As disclosed in Patent Documents 1 and 2 above, various types of acidic-type foods and drinks containing proteins are known. However, in Patent Document 1, storage stability is improved by hardening with a gelling agent. It is a highly gelled food product, and it is difficult to say that protein aggregation is suppressed in the acidic region.
　特許文献２は、有機酸モノグリセリドが必須原料であり、増粘させて安定性を付与しているゲル状食品であって、酸性域での蛋白質の凝集そのものを改善しているものではなく、経時的な安定性についても満足とはいい難い。 Patent Document 2 is a gel-like food in which organic acid monoglyceride is an essential raw material and imparts stability by increasing the viscosity, and does not improve protein aggregation itself in the acidic region. It is difficult to say that the stability of the product is satisfactory.
　したがって、市場では、チューブ詰まりや、細菌汚染等が生じにくく、使用しやすい液状経腸栄養剤が求められていた。 Therefore, there has been a demand for a liquid enteral nutrient that is less likely to be clogged or contaminated with bacteria and that is easy to use.
　本発明の目的は、酸性下であっても、蛋白質の安定性が高く、適度な粘度を有し、チューブ流動性に優れた酸性液状流動食を提供することを目的とする。 An object of the present invention is to provide an acidic liquid liquid food having high protein stability, moderate viscosity, and excellent tube fluidity even under acidic conditions.
　本発明者は、上記問題点に鑑み鋭意研究を重ねた結果、蛋白質と有機酸の配合比率を設定することにより上記課題が解決できることを見出して本発明を完成した。すなわち、本発明は次の酸性液状栄養剤に係る。 As a result of intensive studies in view of the above problems, the present inventor has found that the above problems can be solved by setting the blending ratio of protein and organic acid, and has completed the present invention. That is, the present invention relates to the following acidic liquid nutrient.
　（１）糖質、蛋白質源、脂質、および有機酸を含む酸性液状栄養剤であって、前記有機酸の配合比率が、蛋白質源１部に対して、０．１５～０．４５部である酸性液状栄養剤。 (1) An acidic liquid nutrient containing a sugar, a protein source, a lipid, and an organic acid, wherein the organic acid content is 0.15 to 0.45 parts relative to 1 part of the protein source Acid liquid nutrient.
　（２）２５℃での粘度が１０～１５０ｍＰａ・ｓである上記（１）に記載の酸性液状栄養剤。 (2) The acidic liquid nutrient according to (1) above, having a viscosity at 25 ° C. of 10 to 150 mPa · s.
　（３）ｐＨが３．０～４．０である上記（１）または（２）に記載の酸性液状栄養剤。 (3) The acidic liquid nutrient according to (1) or (2) above, which has a pH of 3.0 to 4.0.
　（４）粒度分布計で測定した際の平均粒子径が１５μｍ以下である上記（１）～（３）のいずれか一つに記載の酸性液状栄養剤。 (4) The acidic liquid nutrient according to any one of the above (1) to (3), wherein an average particle diameter measured by a particle size distribution meter is 15 μm or less.
　（５）蛋白質源が、ホエイ蛋白質および／または植物性蛋白である上記（１）～（４）のいずれか一つに記載の酸性液状流動食。 (5) The acidic liquid liquid food according to any one of (1) to (4) above, wherein the protein source is whey protein and / or vegetable protein.
　（６）前記植物性蛋白質が、大豆蛋白質である上記（５）に記載の酸性液状流動食。 (6) The acidic liquid liquid food according to the above (5), wherein the vegetable protein is soybean protein.
　本発明の酸性液状栄養剤は、安定性が高く、チューブを介して栄養剤を投与する場においても、チューブ詰まりの発生がない酸性液状栄養剤である。したがって、介護時に流量の再調整などの手間を要することなく、確実に安心かつ容易に栄養を摂取することが可能となる。 The acidic liquid nutrient of the present invention is an acidic liquid nutrient that has high stability and does not cause tube clogging even when the nutrient is administered through a tube. Therefore, it is possible to reliably and easily ingest nutrition without the need for readjustment of the flow rate during nursing care.
　本発明の経腸栄養法に適した酸性液状栄養剤は、該栄養剤中に糖質、蛋白質源、脂質および、所定量の有機酸を配合することを一つの大きな特徴とする。 The acidic liquid nutrient suitable for the enteral nutrition method of the present invention is characterized in that a carbohydrate, a protein source, a lipid, and a predetermined amount of an organic acid are blended in the nutrient.
　かかる特徴を有することで、従来の酸性液状栄養剤と異なり、適度な粘度を有し、蛋白質源の安定性に優れた特徴を有する。これにより従来の栄養剤で課題となってきたゲル化剤や乳化剤の増加が抑えられる。このため、チューブを介して投与する場合においても、投与中のチューブ詰まりの発生を防止することが出来る。更には酸性域であるため、細菌汚染等のリスクが低減されるという効果がある。 By having such characteristics, unlike conventional acidic liquid nutrients, it has moderate viscosity and excellent protein source stability. Thereby, the increase in the gelling agent and emulsifier which has been a problem with the conventional nutrients can be suppressed. For this reason, also when administering via a tube, generation | occurrence | production of the tube clogging during administration can be prevented. Furthermore, since it is an acidic region, there is an effect that the risk of bacterial contamination and the like is reduced.
　以下に、本発明の酸性液状栄養剤について、更に詳述する。 Hereinafter, the acidic liquid nutrient of the present invention will be described in more detail.
　（酸性液状栄養剤）
　本発明の一実施形態によると、酸性液状栄養剤は、糖質、蛋白質源、脂質および、所定量の有機酸を含む。 (Acid liquid nutrient)
According to one embodiment of the present invention, the acidic liquid nutrient contains a sugar, a protein source, a lipid, and a predetermined amount of an organic acid.
　（有機酸）
　有機酸としては、特に制限されないが、酢酸、クエン酸、コハク酸、乳酸、リンゴ酸、酒石酸、グルコン酸等が用いられうる。これらの酸味料は単独で用いても、２種以上を混合して用いてもよい。酸性液状栄養剤中の有機酸の配合比率は、蛋白質源１部に対して、０．１５～０．４５部であることが好ましく、０．１９～０．４０部であることがより好ましい。 (Organic acid)
The organic acid is not particularly limited, and acetic acid, citric acid, succinic acid, lactic acid, malic acid, tartaric acid, gluconic acid and the like can be used. These acidulants may be used alone or in combination of two or more. The blending ratio of the organic acid in the acidic liquid nutrient is preferably 0.15 to 0.45 part, more preferably 0.19 to 0.40 part with respect to 1 part of the protein source.
　（栄養素）
　栄養素としては、好適には糖質、蛋白質源、脂質を含む。前記栄養素は、任意の成分として、さらに、ビタミン、ミネラル、および食物繊維からなる群から選択される少なくとも１種を含んでいてもよい。酸性液状栄養剤中の栄養素の合計量は、８～６０質量％であることが好ましく、１５～４０質量％であることがより好ましい。 (Nutrient)
Nutrients preferably include carbohydrates, protein sources, and lipids. The nutrient may further contain at least one selected from the group consisting of vitamins, minerals, and dietary fiber as an optional component. The total amount of nutrients in the acidic liquid nutrient is preferably 8 to 60% by mass, and more preferably 15 to 40% by mass.
　（糖質）
　糖質は、炭水化物とも呼ばれ、エネルギー源となるものである。糖質としては、生体に吸収されてエネルギー源になるものであれば特に制限はなく、例えば、単糖、二糖、および多糖が挙げられる。単糖の具体例としては、グルコース（ブドウ糖）、フルクトース（果糖）、ガラクトース等が挙げられる。二糖の具体例としては、スクロース（ショ糖）、ラクトース（乳糖）、マルトース（麦芽糖）、イソマルトース、トレハロース等が挙げられる。多糖の具体例としては、デンプン（アミロース、アミロペクチン）、デキストリン等が挙げられる。これらのうち、デキストリンを用いることが好ましい。 (Sugar)
Carbohydrates are also called carbohydrates and serve as energy sources. The carbohydrate is not particularly limited as long as it is absorbed into the living body and becomes an energy source, and examples thereof include monosaccharides, disaccharides, and polysaccharides. Specific examples of monosaccharides include glucose (glucose), fructose (fructose), galactose and the like. Specific examples of the disaccharide include sucrose (sucrose), lactose (lactose), maltose (malt sugar), isomaltose, trehalose and the like. Specific examples of the polysaccharide include starch (amylose, amylopectin), dextrin and the like. Of these, dextrin is preferably used.
　デキストリンは、数個のα－グルコースがグリコシド結合によって重合した物質の総称であり、デンプンを加水分解して得ることができる。デキストリンは、小腸内での分解速度が遅く吸収が緩やかであることから、急激な血糖上昇を防止しうる。また、デキストリンを用いることにより、酸性液状栄養剤の浸透圧を低減することができ、浸透圧性の下痢を予防しうる。デキストリンとしては、α－グルコースの重合度が高い高分子デキストリン、およびα－グルコースの重合度が低い低分子デキストリンのいずれを用いてもよいが、より浸透圧を低減可能な高分子デキストリンを用いることが好ましい。なお、低分子デキストリンは、マルトデキストリンとも呼ばれ、通常、３～５個のα－グルコースが重合したものである。 Dextrin is a general term for substances in which several α-glucoses are polymerized by glycosidic bonds, and can be obtained by hydrolysis of starch. Since dextrin has a slow degradation rate in the small intestine and is slowly absorbed, it can prevent a rapid increase in blood sugar. Further, by using dextrin, the osmotic pressure of the acidic liquid nutrient can be reduced, and osmotic diarrhea can be prevented. As the dextrin, either a high molecular dextrin having a high degree of polymerization of α-glucose or a low molecular dextrin having a low degree of polymerization of α-glucose may be used, but a high molecular dextrin capable of further reducing the osmotic pressure should be used. Is preferred. The low molecular dextrin is also called maltodextrin and is usually a polymer of 3 to 5 α-glucose.
　デキストリンは、自ら調製しても、市販品を用いてもよい。デキストリンを調製する場合には、公知のデンプン、例えば、トウモロコシ、ワキシーコーン、小麦、米、ワキシーライス、ワキシーミロ、豆（ソラマメ、緑豆、小豆等）、馬鈴薯、甘藷、タピオカ等に含有されるデンプンを、公知の方法により加水分解することで調製することができる。一方、市販されたデキストリンとしては、ＴＫ－１６（松谷化学工業株式会社製）等が挙げられ、好適に使用することができる。 Dextrin may be prepared by itself or a commercially available product may be used. When preparing dextrin, known starches such as corn, waxy corn, wheat, rice, waxy rice, waxy miro, beans (broad beans, mung beans, red beans, etc.), potatoes, sweet potatoes, tapioca, etc. It can be prepared by hydrolysis by a known method. On the other hand, examples of commercially available dextrin include TK-16 (manufactured by Matsutani Chemical Industry Co., Ltd.) and the like, which can be preferably used.
　上記の糖質は、単独で用いても、２種以上を混合して用いてもよい。酸性液状栄養剤中の糖質の含有量は、適用する対象者によって適宜調節されうるが、酸性液状栄養剤全量に対して５～３０質量％であることが好ましい。 The above saccharides may be used alone or in admixture of two or more. The content of the saccharide in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied, but is preferably 5 to 30% by mass with respect to the total amount of the acidic liquid nutrient.
　（蛋白質源）
　蛋白質源としては、特に制限されず、公知のものが用いられうる。アミノ酸としては、バリン、ロイシン、イソロイシン、リジン、メチオニン、フェニルアラニン、トレオニン、トリプトファン、ヒスチジン等の必須アミノ酸；およびグリシン、アラニン、セリン、システイン、アスパラギン、グルタミン、プロリン、チロシン、アスパラギン酸、グルタミン酸、アルギニン等の非必須アミノ酸が挙げられる。これらの他、４－ヒドロキシプロリン、５－ヒドロキシリジン、γ－カルボキシグルタミン酸、Ｏ－ホスホセリン、Ｏ－ホスホチロシン、Ｎ－アセチルセリン、Ｎω－メチルアルギニン、ピログルタミン酸、Ｍ－ホルミルメチオニン等の修飾アミノ酸；オルニチン、シトルリン、γ－アミノ酪酸（ＧＡＢＡ）、チロキシン、Ｓ－アデニルメチオニン等の特殊アミノ酸も包含されうる。また、前記アミノ酸は、それぞれ立体異性体（エナンチオマー、ジアステレオマー）であっても、位置異性体であってもよく、これらの混合物であってもよい。さらに、前記アミノ酸は、無機酸塩（塩酸塩等）、有機酸塩（酢酸塩等）、生体内で加水分解可能なエステル体（メチルエステル等）の形態であってもよい。 (Protein source)
The protein source is not particularly limited, and known proteins can be used. Amino acids include essential amino acids such as valine, leucine, isoleucine, lysine, methionine, phenylalanine, threonine, tryptophan, histidine; and glycine, alanine, serine, cysteine, asparagine, glutamine, proline, tyrosine, aspartic acid, glutamic acid, arginine, etc. Of the non-essential amino acids. Other than these, modified amino acids such as 4-hydroxyproline, 5-hydroxylysine, γ-carboxyglutamic acid, O-phosphoserine, O-phosphotyrosine, N-acetylserine, N ω -methylarginine, pyroglutamic acid, M-formylmethionine; Special amino acids such as ornithine, citrulline, γ-aminobutyric acid (GABA), thyroxine, S-adenylmethionine can also be included. The amino acids may be stereoisomers (enantiomers, diastereomers), positional isomers, or a mixture thereof. Furthermore, the amino acid may be in the form of an inorganic acid salt (hydrochloride or the like), an organic acid salt (acetate or the like), or an ester body (methyl ester or the like) that can be hydrolyzed in vivo.
　ペプチドとしては、上記アミノ酸の２以上がペプチド結合（アミド結合）を介して重合したものが用いられうる。当該ペプチドは、ジペプチド、トリペプチド、オリゴペプチド（アミノ酸が約１０個程度のもの）、ポリペプチド（アミノ酸が数十～数百個のもの）のいずれであってもよい。前記ポリペプチドは、植物蛋白質や動物性蛋白質等の蛋白質を含む。なお、一部のオリゴペプチド、例えば、ラクトトリペプチド、カゼインドデカペプチド、バリルチロシン含有サーデンペプチド等は降圧作用等の機能を有しうる。 As the peptide, one obtained by polymerizing two or more of the above amino acids via a peptide bond (amide bond) can be used. The peptide may be a dipeptide, a tripeptide, an oligopeptide (having about 10 amino acids), or a polypeptide (having several tens to several hundred amino acids). The polypeptide includes proteins such as plant proteins and animal proteins. Some oligopeptides such as lactotripeptide, casein decapeptide, valyltyrosine-containing sadden peptide and the like may have functions such as antihypertensive action.
　植物蛋白質としては、米等の穀類、大豆、豆腐等の豆類等に含まれる蛋白質が挙げられる。なお、大豆蛋白質については、胆汁酸と結合してコレステロールの排泄を促進する等の保健機能を有しうる。 Examples of plant proteins include proteins contained in grains such as rice and beans such as soybeans and tofu. The soy protein may have a health function such as binding to bile acid to promote cholesterol excretion.
　動物性蛋白質としては、卵、肉類、魚介類、牛乳等に含まれる蛋白質が挙げられる。 Examples of animal proteins include proteins contained in eggs, meat, seafood, milk and the like.
　これらのうち、牛乳（乳清）を原料とするホエイ蛋白質、大豆蛋白質を用いることが好ましく、ホエイ蛋白質を用いることがより好ましい。ホエイ蛋白質としては、ホエイプロテインコンセントレート（ＷＰＣ）、ホエイプロテインアイソレート（ＷＰＩ）、加水分解ホエイペプチド（ＷＰＨ）等が挙げられる。ＷＰＣやＷＰＩ、大豆蛋白等は市販されているものを用いてもよく、ホエイ蛋白質としては、ＷＰＣ３９２（Ｆｏｎｔｅｒｒａ社製）、ＷＰＣ８０（Ｆｏｎｔｅｒｒａ社製）、大豆蛋白質としては、プロリーナ（登録商標）９００（不二製油株式会社製）、プロリーナ（登録商標）３００（不二製油株式会社製）等が挙げられる。 Among these, it is preferable to use whey protein and soybean protein made from milk (whey) as raw materials, and more preferably whey protein. Examples of whey proteins include whey protein concentrate (WPC), whey protein isolate (WPI), and hydrolyzed whey peptide (WPH). WPC, WPI, soybean protein, and the like may be commercially available. As whey protein, WPC392 (manufactured by Fonterra), WPC80 (manufactured by Fontera), and as soy protein, Prolina (registered trademark) 900 (registered trademark) Fuji Oil Co., Ltd.), Prolina (registered trademark) 300 (Fuji Oil Co., Ltd.) and the like.
　上記の蛋白質源、アミノ酸またはペプチドは、単独で用いても、２種以上を混合して用いてもよい。酸性液状栄養剤中の蛋白質源の含有量は、適用する対象者によって適宜調節されうるが、酸性液状栄養剤全量に対して２～１５質量％であることが好ましい。 The above protein source, amino acid or peptide may be used alone or in combination of two or more. The content of the protein source in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied, but is preferably 2 to 15% by mass with respect to the total amount of the acidic liquid nutrient.
　（脂質）
　脂質は、エネルギー源、生体膜構成成分、ステロイドホルモンや胆汁酸の合成原料となりうる。脂質としては、特に制限されず、飽和脂肪酸、不飽和脂肪酸、植物油、動物性油脂、魚油等が挙げられる。 (Lipid)
Lipids can be a source of energy, biomembrane constituents, steroid hormones and bile acids. The lipid is not particularly limited, and examples thereof include saturated fatty acids, unsaturated fatty acids, vegetable oils, animal fats and oils, and fish oils.
　飽和脂肪酸としては、カプリル酸、カプリン酸、ラウリン酸、パルミチン酸、ステアリン酸等が挙げられる。 Examples of saturated fatty acids include caprylic acid, capric acid, lauric acid, palmitic acid, stearic acid and the like.
　不飽和脂肪酸としては、オレイン酸、パルミトレイン酸、リノール酸、アラキドン酸、α－リノレン酸、エイコサペンタエン酸（ＥＰＡ）、ドコサヘキサエン酸（ＤＨＡ）等が挙げられる。なお、ＥＰＡやＤＨＡについては、血中コレステロール上昇抑制作用、中性脂肪上昇抑制作用等の機能を有しうる。 Examples of unsaturated fatty acids include oleic acid, palmitoleic acid, linoleic acid, arachidonic acid, α-linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). In addition, about EPA and DHA, it can have functions, such as a blood cholesterol raise inhibitory effect and a neutral fat rise inhibitory effect.
　植物油としては、ココナッツオイル、コーン油、綿実油、オリーブオイル、パーム油、パーム核油、ピーナッツ油、菜種油、サフラワー油（紅花油）、ごま油、大豆油、ヒマワリ油、アーモンド油、カシュー油、ヘーゼルナッツ油、マカダミアナッツ油、モンゴンゴ油、ペカン油、松の実油、ピスタチオ油、クルミ油、ヒョウタン実油、バッファローカボチャ油、カボチャ実油、スイカ実油、アマランサスオイル、あんず油、リンゴ油、アルガンオイル、アボカド油、ババスオイル、モリンガ油、ボルネオ脂、ケープ栗油、ココアバター、キャロブオイル、コフネヤシ油、コリアンダー種油、ディカ油、アマニ油、グレープシードオイル、ヘンプオイル、カポック実油、ラッレマンチアオイル、マルーラ油、メドウフォーム油、カラシ油、ナツメグバター、オクラ油、パパイヤ油、シソ油、ペクイ油、松の実油、ケシ油、プルーン油、キヌア油、ニガー種子油、こめ油、Ｒｏｙｌｅ油、サッチャインチオイル、ツバキ油、アザミ油、トマト油、コムギ油、エゴマ油、サンフラワー油、胚芽油、ヤシ油、落花生油等が挙げられる。 Vegetable oils include coconut oil, corn oil, cottonseed oil, olive oil, palm oil, palm kernel oil, peanut oil, rapeseed oil, safflower oil (safflower oil), sesame oil, soybean oil, sunflower oil, almond oil, cashew oil, hazelnut Oil, macadamia nut oil, mongolian oil, pecan oil, pine nut oil, pistachio oil, walnut oil, gourd seed oil, buffalo pumpkin oil, pumpkin seed oil, watermelon seed oil, amaranth oil, apricot oil, apple oil, argan oil , Avocado oil, babas oil, moringa oil, borneo oil, cape chestnut oil, cocoa butter, carob oil, kofne palm oil, coriander seed oil, dica oil, flaxseed oil, grape seed oil, hemp oil, kapok seed oil, lale mantia oil , Marula oil, Meadow foam oil, mustard oil, Tsumug butter, okra oil, papaya oil, perilla oil, pequi oil, pine nut oil, poppy oil, prune oil, quinoa oil, niger seed oil, rice bran oil, Royle oil, Thatcha inch oil, camellia oil, thistle oil, tomato oil , Wheat oil, sesame oil, sunflower oil, germ oil, coconut oil, peanut oil and the like.
　動物性油脂としては、ラード（豚脂）、ヘット（牛脂）、乳脂等が挙げられる。 Animal fats include lard (pig fat), head (tallow), milk fat, and the like.
　魚油としては、サバ、サケ、ブリ、イワシ、サンマ等の魚油が挙げられる。 Fish oil includes fish oil such as mackerel, salmon, yellowtail, sardine, saury.
　これらのうち、ヒトが生体内で合成することができないリノール酸およびα－リノレン酸、またはこれらを含む脂質を用いることが好ましい。 Among these, it is preferable to use linoleic acid and α-linolenic acid that cannot be synthesized in vivo by humans, or lipids containing these.
　上記の脂質は、単独で用いても、２種以上を混合して用いてもよい。酸性液状栄養剤中の脂質の含有量は、適用する対象者によって適宜調節されうるが、酸性液状栄養剤全量に対して１～８質量％であることが好ましい。 The above lipids may be used alone or in combination of two or more. The lipid content in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied, but is preferably 1 to 8% by mass with respect to the total amount of the acidic liquid nutrient.
　（ビタミン）
ビタミンとは、生物の栄養状態を保つために必要とする糖質、アミノ酸またはペプチド、脂質以外の有機化合物の総称である。ビタミンとしては、ビタミンＡ（レチノール）、ビタミンＤ（エルゴカルシフェロール、コレカルシフェロール）、ビタミンＥ（トコフェロール、トコトリエノール）ビタミンＫ（フィロキノン、メナキノン）等の脂溶性ビタミン：ビタミンＢ１（チアミン）、ビタミンＢ２（リボフラビン）、ビタミンＢ３（ナイアシン）、ビタミンＢ５（パントテン酸）、ビタミンＢ６（ピリドキサール、ピリドキサミン、ピリドキシン）、ビタミンＢ７（ビオチン）、ビタミンＢ９（葉酸）、ビタミンＢ１２（シアノコバラミン、ヒドロキソコバラミン）、ビタミンＣ（アスコルビン酸）等の水溶性ビタミンが挙げられる。これらのビタミンは、単独で用いても、２種以上を混合して用いてもよい。 (vitamin)
Vitamins are a general term for organic compounds other than carbohydrates, amino acids or peptides, and lipids that are necessary for maintaining the nutritional state of organisms. Vitamin A (retinol), vitamin D (ergocalciferol, cholecalciferol), vitamin E (tocopherol, tocotrienol) vitamin K (phylloquinone, menaquinone) and other fat-soluble vitamins: vitamin B1 (thiamine), vitamin B2 (Riboflavin), vitamin B3 (niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxal, pyridoxamine, pyridoxine), vitamin B7 (biotin), vitamin B9 (folic acid), vitamin B12 (cyanocobalamin, hydroxocobalamin), vitamin C And water-soluble vitamins such as (ascorbic acid). These vitamins may be used alone or in combination of two or more.
　酸性液状栄養剤中のビタミンの含有量は、適用する対象者等によって適宜調節されうる。通常、脂溶性ビタミンについては過剰症が生じない量で添加され、水溶性ビタミンについては添加量に制限はない。酸性液状栄養剤１００ｇあたりの各ビタミンの好ましい含有量は以下の通りである。 The content of vitamins in the acidic liquid nutrient can be adjusted as appropriate by the subject to be applied. Normally, fat-soluble vitamins are added in an amount that does not cause excess disease, and water-soluble vitamins are not limited in the amount added. The preferable content of each vitamin per 100 g of acidic liquid nutrient is as follows.
　・脂溶性ビタミン
　ビタミンＡ：好ましくは０～３０００μｇ、より好ましくは２０～２００μｇ
　ビタミンＤ：好ましくは０．１～５０μｇ、より好ましくは０．１～５．０μｇ
　ビタミンＥ：好ましくは０．２～８００ｍｇ、より好ましくは１～１０ｍｇ
　ビタミンＫ：好ましくは０．５～１０００μｇ、より好ましくは２～５０μｇ Fat-soluble vitamin Vitamin A: preferably 0 to 3000 μg, more preferably 20 to 200 μg
Vitamin D: preferably 0.1-50 μg, more preferably 0.1-5.0 μg
Vitamin E: preferably 0.2 to 800 mg, more preferably 1 to 10 mg
Vitamin K: preferably 0.5 to 1000 μg, more preferably 2 to 50 μg
　・水溶性ビタミン
　ビタミンＢ１：好ましくは０．０１～４０ｍｇ、より好ましくは０．１～１０ｍｇ
　ビタミンＢ２：好ましくは０．０１～２０ｍｇ、より好ましくは０．０５～１０ｍｇ
　ナイアシン：好ましくは０．１～３００ｍｇＮＥ、より好ましくは０．５～６０ｍｇＮＥ
　パントテン酸：好ましくは０．１～５５ｍｇ、より好ましくは０．２～３０ｍｇ
　ビタミンＢ６：好ましくは０．０１～６０ｍｇ、より好ましくは０．１～３０ｍｇ
　ビオチン：好ましくは０．１～１０００μｇ、より好ましくは１～１００μｇ
　葉酸：好ましくは１～１０００μｇ、より好ましくは１０～２００μｇ
　ビタミンＢ１２：好ましくは０．０１～１００μｇ、より好ましくは０．２～６０μｇ　ビタミンＣ：好ましくは１～２０００ｍｇ、より好ましくは５～１０００ｍｇ Water-soluble vitamin Vitamin B1: preferably 0.01 to 40 mg, more preferably 0.1 to 10 mg
Vitamin B2: preferably 0.01-20 mg, more preferably 0.05-10 mg
Niacin: preferably 0.1 to 300 mg NE, more preferably 0.5 to 60 mg NE
Pantothenic acid: preferably 0.1 to 55 mg, more preferably 0.2 to 30 mg
Vitamin B6: preferably 0.01-60 mg, more preferably 0.1-30 mg
Biotin: preferably 0.1 to 1000 μg, more preferably 1 to 100 μg
Folic acid: preferably 1-1000 μg, more preferably 10-200 μg
Vitamin B12: preferably 0.01-100 μg, more preferably 0.2-60 μg Vitamin C: preferably 1-2000 mg, more preferably 5-1000 mg
　（ミネラル）
　ミネラルとは、生物の栄養状態を保つために必要とする有機化合物以外の元素である。　ミネラルとしては、ナトリウム、カリウム、カルシウム、リン、マグネシウム等の準主要元素；鉄、亜鉛、銅、ヨウ素、マンガン、セレン、クロム、モリブデン等の必須微量元素等が挙げられる。これらのミネラルは、単独で用いても、２種以上を混合して用いてもよい。 (mineral)
Minerals are elements other than organic compounds that are necessary for maintaining the nutritional state of living organisms. Examples of the mineral include quasi-major elements such as sodium, potassium, calcium, phosphorus and magnesium; essential trace elements such as iron, zinc, copper, iodine, manganese, selenium, chromium and molybdenum. These minerals may be used alone or in combination of two or more.
　酸性液状栄養剤中のミネラルの含有量は、適用する対象者等によって適宜調節されうる。酸性液状栄養剤１００ｇあたりの各ミネラルの好ましい含有量は以下の通りである。 The content of mineral in the acidic liquid nutrient can be adjusted as appropriate by the subject to be applied. The preferable content of each mineral per 100 g of acidic liquid nutrient is as follows.
　・準主要元素
　ナトリウム：好ましくは５～６０００ｍｇ、より好ましくは１０～３５００ｍｇ
　カリウム：好ましくは１～３５００ｍｇ、より好ましくは２５～１８００ｍｇ
　カルシウム：好ましくは１０～２３００ｍｇ、より好ましくは３０～３００ｍｇ
　リン：好ましくは１～３５００ｍｇ、より好ましくは２５～１５００ｍｇ
　マグネシウム：好ましくは１～７４０ｍｇ、より好ましくは１０～１５０ｍｇ Semi-major element sodium: preferably 5 to 6000 mg, more preferably 10 to 3500 mg
Potassium: preferably 1 to 3500 mg, more preferably 25 to 1800 mg
Calcium: preferably 10-2300 mg, more preferably 30-300 mg
Phosphorus: preferably 1 to 3500 mg, more preferably 25 to 1500 mg
Magnesium: preferably 1 to 740 mg, more preferably 10 to 150 mg
　・必須微量元素
　鉄：好ましくは０．１～５５ｍｇ、より好ましくは１～１０ｍｇ
　亜鉛：好ましくは０．１～３０ｍｇ、より好ましくは１～１５ｍｇ
　銅：好ましくは０．０１～１０ｍｇ、より好ましくは０．０６～６ｍｇ
　ヨウ素：好ましくは０．１～３０００μｇ、より好ましくは１～１５０μｇ
　マンガン：好ましくは０．０１～１１ｍｇ、より好ましくは０．１～４ｍｇ
　セレン：好ましくは０．１～４５０μｇ、より好ましくは１～３５μｇ
　クロム：好ましくは０．１～４０μｇ、より好ましくは１～３５μｇ
　モリブデン：好ましくは０．１～３２０μｇ、より好ましくは１～２５μｇ Essential trace element Iron: preferably 0.1 to 55 mg, more preferably 1 to 10 mg
Zinc: preferably 0.1-30 mg, more preferably 1-15 mg
Copper: preferably 0.01 to 10 mg, more preferably 0.06 to 6 mg
Iodine: preferably 0.1 to 3000 μg, more preferably 1 to 150 μg
Manganese: preferably 0.01 to 11 mg, more preferably 0.1 to 4 mg
Selenium: preferably 0.1 to 450 μg, more preferably 1 to 35 μg
Chromium: preferably 0.1 to 40 μg, more preferably 1 to 35 μg
Molybdenum: preferably 0.1 to 320 μg, more preferably 1 to 25 μg
　（食物繊維）
　食物繊維は、栄養素利用度の低下、血漿コレステロールの低下、血糖応答の改善、大腸機能の改善、および大腸がんの予防等の機能を有しうる。なお、食物繊維は、腸内細菌により醗酵を受けて短鎖脂肪酸、炭酸ガス、水素ガス、メタンガス等に変換される場合がある。このうち、短鎖脂肪酸については大腸で吸収されるため、食物繊維はエネルギー源となる場合がある。 (Dietary fiber)
Dietary fiber can have functions such as reduced nutrient utilization, reduced plasma cholesterol, improved blood glucose response, improved colon function, and prevention of colon cancer. In addition, dietary fiber may be fermented by intestinal bacteria and converted to short chain fatty acids, carbon dioxide gas, hydrogen gas, methane gas, and the like. Among these, since short chain fatty acids are absorbed in the large intestine, dietary fiber may be an energy source.
　食物繊維としては、特に制限されないが、セルロース、ヘミセルロース、リグニン、不溶性ペクチン、キチン、キトサン、サイリウム種皮、低分子化アルギン酸ナトリウム等の不溶性食物繊維；水溶性ペクチン、グアガム、コンニャクマンナン、グルコマンナン、アルギン酸、寒天、化学修飾多糖類、ポリデキストロース、難消化性オリゴ糖、マルチトール、イヌリン、カラギナン、小麦ふすま、難消化性デキストリン（例えば、パインファイバーＣ（松谷化学工業社製）、ポリデキストロース、グアガム分解物、等の水溶性食物繊維等が挙げられる。 The dietary fiber is not particularly limited, but is insoluble dietary fiber such as cellulose, hemicellulose, lignin, insoluble pectin, chitin, chitosan, psyllium seed, low molecular weight sodium alginate; water-soluble pectin, guar gum, konjac mannan, glucomannan, alginic acid , Agar, chemically modified polysaccharide, polydextrose, indigestible oligosaccharide, maltitol, inulin, carrageenan, wheat bran, indigestible dextrin (eg, Pine Fiber C (manufactured by Matsutani Chemical Co., Ltd.), polydextrose, guar gum decomposition And water-soluble dietary fiber such as food.
　これらの食物繊維は、単独で用いても、２種以上を混合して用いてもよい。酸性液状栄養剤中の食物繊維の含有量は、適用する対象者等によって適宜調節されうる。 These dietary fibers may be used alone or in combination of two or more. The content of dietary fiber in the acidic liquid nutrient can be adjusted as appropriate by the subject to be applied.
　（水分）
　本発明に係る酸性液状栄養剤は、好適には水分を含む。酸性液状栄養剤中の水分の含有量は、適用する対象者や所望とする粘度等によって適宜調節されうるが、酸性液状栄養剤全量に対して３０～９０質量％であることが好ましく、水分管理の観点から５０～９０質量％であることがより好ましい。 (moisture)
The acidic liquid nutrient according to the present invention preferably contains moisture. The water content in the acidic liquid nutrient can be adjusted as appropriate depending on the subject to be applied, the desired viscosity, etc., but is preferably 30 to 90% by mass with respect to the total amount of the acidic liquid nutrient. From the viewpoint of the above, it is more preferably 50 to 90% by mass.
　（その他の成分）
　本形態に係る酸性液状栄養剤は、さらにその他の公知の成分、例えば、以下に示す成分等を含んでいてもよい。 (Other ingredients)
The acidic liquid nutrient according to the present embodiment may further contain other known components such as the following components.
　（保健機能成分）
　保健機能成分とは、摂取することによって生体に対し一定の機能を発揮する成分である。例えば、難消化性オリゴ糖、糖アルコール、クエン酸リンゴ酸カルシウム（ＣＣＭ）およびカゼインホスホペプチド（ＣＰＰ）、キトサン、Ｌ－アラビノース、グァバ葉ポリフェノール、小麦アルブミン、豆鼓エキス、ジアシルグリセロール、ジアシルグリセロール植物性ステロール、大豆イソフラボン、乳塩基性蛋白質等が挙げられる。 (Health functional ingredient)
A health function component is a component that exhibits a certain function for a living body when ingested. For example, resistant oligosaccharide, sugar alcohol, calcium citrate malate (CCM) and casein phosphopeptide (CPP), chitosan, L-arabinose, guava leaf polyphenol, wheat albumin, bean extract, diacylglycerol, diacylglycerol plant Sterols, soy isoflavones, milk basic proteins and the like.
　（難消化性オリゴ糖）
　難消化性オリゴ糖とは、単糖類がグリコシド結合によって結合した化合物のうち、多糖類ほどは分子量が大きくない（３００～３０００程度）糖類である。前記難消化性オリゴ糖はヒトの消化酵素では分解されず、ヒトの消化酵素で分解されるものについては、上記の糖質に包含されうる。難消化性オリゴ糖を摂取することにより、整腸効果が得られうる。 (Indigestible oligosaccharide)
The indigestible oligosaccharide is a saccharide whose molecular weight is not as large as that of a polysaccharide (about 300 to 3,000) among compounds in which monosaccharides are bound by glycosidic bonds. The indigestible oligosaccharides are not degraded by human digestive enzymes, but those digested by human digestive enzymes can be included in the above-mentioned carbohydrates. Ingestion of indigestible oligosaccharides can provide a bowel regulation effect.
　難消化性オリゴ糖としては、特に制限されないが、キシロオリゴ糖、フラクトオリゴ糖、大豆オリゴ糖、イソマルトオリゴ糖、乳果オリゴ糖、ラクチュロース、ガラクトオリゴ糖等が挙げられる。これらの難消化性オリゴ糖は、単独で用いても、２種以上を混合して用いてもよい。酸性液状栄養剤中の難消化性オリゴ糖の含有量は、適用する対象者等によって適宜調節されうる。 The indigestible oligosaccharide is not particularly limited, and examples thereof include xylooligosaccharide, fructooligosaccharide, soybean oligosaccharide, isomaltooligosaccharide, dairy oligosaccharide, lactulose, and galactooligosaccharide. These indigestible oligosaccharides may be used alone or in combination of two or more. The content of the indigestible oligosaccharide in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.
　（糖アルコール）
　糖アルコールとは、アルドースやケトースのカルボニル基が還元されて生成する糖の一種であり、小腸から体内への吸収が悪くカロリーになりにくいものである。糖アルコールは、口内細菌によって酸に代謝されにくく、歯垢の形成を防止しうる。当該糖アルコールは、低カロリー甘味料として用いられうる。 (Sugar alcohol)
Sugar alcohol is a kind of sugar produced by reducing the carbonyl group of aldose or ketose, and is poorly absorbed from the small intestine into the body and is not easily caloric. Sugar alcohol is difficult to be metabolized to acid by oral bacteria and can prevent plaque formation. The sugar alcohol can be used as a low calorie sweetener.
　糖アルコールとしては、エリトリトール、マルチトール、パラチノース等が挙げられる。これらの糖アルコールは、単独で用いても、２種以上を混合して用いてもよい。 Examples of sugar alcohols include erythritol, maltitol, palatinose and the like. These sugar alcohols may be used alone or in admixture of two or more.
　酸性液状栄養剤中の糖アルコールの含有量は、適用する対象者等によって適宜調節されうる。 The content of the sugar alcohol in the acidic liquid nutrient can be adjusted as appropriate by the subject to be applied.
　（クエン酸リンゴ酸カルシウム（ＣＣＭ）およびカゼインホスホペプチド（ＣＰＰ））　ＣＣＭおよびＣＰＰは、カルシウムの吸収を促進し、骨形成を促進しうる。当該ＣＣＭおよびＣＰＰは、単独で用いても、混合して用いてもよい。また、ＣＣＭおよびＣＰＰは、カルシウムと併用することが好ましい。酸性液状栄養剤中のＣＣＭおよびＣＰＰの含有量は、適用する対象者等によって適宜調節されうる。 (Calcium citrate malate (CCM) and casein phosphopeptide (CPP)) CCM and CPP can promote calcium absorption and promote bone formation. The CCM and CPP may be used alone or in combination. CCM and CPP are preferably used in combination with calcium. The contents of CCM and CPP in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.
　（食品添加物）
　食品添加物は、食品の加工もしくは保存の目的で、食品に添加、混和、湿潤その他の方法によって使用するものである。食品添加物としては、栄養強化の目的以外にも、例えば、グルコン酸亜鉛およびグルコン酸銅、アスコルビン酸２－グルコシド、シクロデキストリン、保存料、防かび剤、酸化防止剤、着色料、甘味料、ｐＨ調整剤、酸味剤、乳化剤、香料等が挙げられる。 (Food additive)
The food additive is used for the purpose of processing or storing the food by adding, mixing, moistening or other methods to the food. As food additives, for example, zinc gluconate and copper gluconate, ascorbic acid 2-glucoside, cyclodextrin, preservatives, fungicides, antioxidants, coloring agents, sweeteners, A pH adjuster, a sour agent, an emulsifier, a fragrance | flavor, etc. are mentioned.
　（グルコン酸亜鉛およびグルコン酸銅）
　グルコン酸亜鉛およびグルコン酸銅は、グルコン酸の重金属イオンとの高いキレート能を利用したグルコン酸塩である。グルコン酸塩の形態とすると吸収されやすくなることから、亜鉛や銅を効果的に吸収することができる。当該グルコン酸亜鉛およびグルコン酸銅は、単独で用いても、混合して用いてもよい。酸性液状栄養剤中のグルコン酸亜鉛およびグルコン酸銅の含有量は、適用する対象者等によって適宜調節されうる。 (Zinc gluconate and copper gluconate)
Zinc gluconate and copper gluconate are gluconates utilizing high chelating ability of gluconic acid with heavy metal ions. Since it becomes easy to be absorbed when it is made into the form of gluconate, zinc and copper can be absorbed effectively. The zinc gluconate and copper gluconate may be used alone or in combination. The content of zinc gluconate and copper gluconate in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.
　（アスコルビン酸２－グルコシド）
　アスコルビン酸２－グルコシドは、ビタミンＣ（アスコルビン酸）の２位の水酸基にグルコースがα－配位で結合した化合物であり、酸素の攻撃を受けないため通常のビタミンＣよりも安定性が高いビタミンＣ誘導体である。アスコルビン酸２－グルコシドによって効率的にビタミンＣを吸収することができる。酸性液状栄養剤中のアスコルビン酸２－グルコシドの含有量は、適用する対象者等によって適宜調節されうる。 (Ascorbic acid 2-glucoside)
Ascorbic acid 2-glucoside is a compound in which glucose is α-coordinated to the hydroxyl group at the 2-position of vitamin C (ascorbic acid) and is more stable than normal vitamin C because it is not attacked by oxygen. C derivative. Vitamin C can be efficiently absorbed by ascorbic acid 2-glucoside. The content of ascorbic acid 2-glucoside in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.
　（シクロデキストリン）
　シクロデキストリンとは、グルコースがグルコシド結合によって結合し、環状構造をとった環状オリゴ糖である。６個のグルコースからなるものをα－シクロデキストリン、７個のグルコースからなるものをβ－シクロデキストリン、８個のグルコースからなるものをγ－シクロデキストリンという。シクロデキストリンは、アレルギー抑制効果、血糖値上昇抑制効果、乳化作用等の機能を有しうる。当該シクロデキストリンは、単独で用いても、２種以上を混合して用いてもよい。酸性液状栄養剤中のシクロデキストリンの含有量は、適用する対象者等によって適宜調節されうる。 (Cyclodextrin)
Cyclodextrin is a cyclic oligosaccharide having a cyclic structure in which glucose is bound by a glucoside bond. Those consisting of 6 glucoses are called α-cyclodextrin, those consisting of 7 glucoses are called β-cyclodextrin, and those consisting of 8 glucoses are called γ-cyclodextrin. Cyclodextrins can have functions such as an allergy suppressing effect, a blood sugar level increase suppressing effect, and an emulsifying action. The said cyclodextrin may be used independently or may be used in mixture of 2 or more types. The content of cyclodextrin in the acidic liquid nutrient can be appropriately adjusted depending on the subject to be applied.
　（酸化防止剤）
　酸化防止剤は、酸性液状栄養剤の酸化による変質を防止する機能を有する。酸化防止剤としては、特に制限されないが、アスコルビン酸およびそのナトリウム塩、エリソルビン酸およびそのナトリウム塩等が用いられうる。これらの酸化防止剤は、単独で用いても、２種以上を混合して用いてもよい。 (Antioxidant)
The antioxidant has a function of preventing deterioration of the acidic liquid nutrient due to oxidation. Although it does not restrict | limit especially as antioxidant, Ascorbic acid and its sodium salt, erythorbic acid, its sodium salt, etc. may be used. These antioxidants may be used alone or in combination of two or more.
　（着色料）
　着色料は、酸性液状栄養剤を美しくする機能を有する。着色料としては、特に制限されないが、食用タール色素（食用赤色２号、３号、４０号、１０２号、１０４号、１０５号、および１０６号、食用青色１号および２号、食用黄色４号および５号、食用緑色３号等）、β－カロテン、水溶性アナトー、クロロフィル誘導体（クロロフィルａ、クロルフィルｂ、銅クロロフィル、銅クロロフィリンナトリウム、鉄クロロフィリンナトリウム等）、リボフラビン、三二酸化鉄、二酸化チタン、ベニバナ黄色素、コチニール色素、クチナシ黄色素、ウコン色素、赤キャベツ色素、ビートレッド、ブドウ果皮色素、パプリカ色素、カラメル等が用いられうる。これらの着色料は、単独で用いても、２種以上を混合して用いてもよい。 (Coloring agent)
The colorant has a function of beautifying the acidic liquid nutrient. Although it does not restrict | limit especially as a coloring agent, Edible tar pigment | dye (Edible red No. 2, No. 3, No. 40, No. 102, No. 104, No. 105, and No. 106, Edible blue No. 1 and No. 2, Edible yellow No. 4 And No. 5, Edible Green No. 3, etc.), β-carotene, water-soluble anato, chlorophyll derivatives (chlorophyll a, chlorphyll b, copper chlorophyll, copper chlorophyllin sodium, iron chlorophyllin sodium, etc.), riboflavin, iron sesquioxide, titanium dioxide Safflower yellow pigment, cochineal pigment, gardenia yellow pigment, turmeric pigment, red cabbage pigment, beet red, grape skin pigment, paprika pigment, caramel and the like can be used. These colorants may be used alone or in admixture of two or more.
　（甘味料）
　甘味料は、酸性液状栄養剤に甘味を付与する機能を有する。甘味料としては、特に制限されないが、サッカリンおよびそのナトリウム塩、キシリトール、アスパルテーム、スクラロース、アセスルファムカリウム、ズルチン、チクロ（サイクラミン酸）、ネオテーム、トレハロース、エリスリトール、マルチトース、パラ地ノース、ソルビトール、甘草抽出物、ステビア加工の甘味料、ソーマチン、クルクリン、リチルリチン酸二ナトリウム等が用いられうる。これらの甘味料は、単独で用いても、２種以上を混合して用いてもよい。 (sweetener)
The sweetener has a function of imparting sweetness to the acidic liquid nutrient. The sweetener is not particularly limited, but saccharin and its sodium salt, xylitol, aspartame, sucralose, acesulfame potassium, dulcin, cyclamate, neotame, trehalose, erythritol, maltose, para-north, sorbitol, licorice extract Stevia processed sweeteners, thaumatin, curculin, disodium lithyrrhizinate and the like can be used. These sweeteners may be used alone or in combination of two or more.
　（ｐＨ調整剤）
　ｐＨ調整剤は、酸性液状栄養剤のｐＨを調整する機能を有する。ｐＨ調整剤としては、特に制限されないが、グルコン酸、コハク酸、炭酸カリウム、炭酸水素ナトリウム、二酸化炭素、乳酸ナトリウム、クエン酸ナトリウム、アジピン酸等が用いられうる。これらのｐＨ調整剤は単独で用いても、２種以上を混合して用いてもよい。 (PH adjuster)
The pH adjuster has a function of adjusting the pH of the acidic liquid nutrient. The pH adjuster is not particularly limited, and gluconic acid, succinic acid, potassium carbonate, sodium hydrogen carbonate, carbon dioxide, sodium lactate, sodium citrate, adipic acid and the like can be used. These pH adjusters may be used alone or in combination of two or more.
　（乳化剤）
　乳化剤は、脂質等の油溶性成分の水への溶解性の向上等の機能を有する。乳化剤としては、特に制限されないが、レシチン、サポニン、カゼインナトリウム等の天然乳化剤や、グリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、プロピレングリコール脂肪酸エステル、ショ糖脂肪酸エステル等の合成乳化剤等が挙げられる。これらの乳化剤は、単独で用いても、２種以上を混合して用いてもよい。 (emulsifier)
The emulsifier has a function of improving the solubility of oil-soluble components such as lipids in water. Although it does not restrict | limit especially as an emulsifier, Synthetic emulsifiers, such as natural emulsifiers, such as a lecithin, saponin, and casein sodium, glycerol fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, etc. are mentioned. These emulsifiers may be used alone or in combination of two or more.
　（香料）
　香料は、酸性液状栄養剤を着香・嬌臭する機能を有する。香料としては、特に制限されないが、アセトフェノン、α－アミルシンナムアルデヒド、アニスアルデヒド、ベンズアルデヒド、酢酸ベンジル、ベンジルアルコール、シンナムアルデヒド、ケイ皮酸、シトラール、シトロネラール、シトロネロール、デカナール、デカノール、アセト酢酸エチル、ケイ皮酸エチル、デカン酸エチル、エチルバニリン、オイゲノール、ゲラニオール、酢酸イソアミル、酪酸イソアミル、フェニル酢酸イソアミル、ｄｌ－メントール、ｌ－メントール、サリチル酸メチル、ピペロナール、プロピオン酸、テルピネオール、バニリン、ｄ－ボルネオール等が挙げられる。これらの香料は、単独で用いても、２種以上を混合して用いてもよい。 (Fragrance)
The fragrance has a function of flavoring and smelling the acidic liquid nutrient. The fragrance is not particularly limited, but acetophenone, α-amylcinnamaldehyde, anisaldehyde, benzaldehyde, benzyl acetate, benzyl alcohol, cinnamaldehyde, cinnamic acid, citral, citronellal, citronellol, decanal, decanol, ethyl acetoacetate, silica Ethyl cinnamate, ethyl decanoate, ethyl vanillin, eugenol, geraniol, isoamyl acetate, isoamyl butyrate, isoamyl phenyl acetate, dl-menthol, l-menthol, methyl salicylate, piperonal, propionic acid, terpineol, vanillin, d-borneol, etc. Can be mentioned. These fragrances may be used alone or in combination of two or more.
　（増粘剤）
　増粘剤は、酸性液状栄養剤に適度な粘性、具体的には、２５℃において、１０～１５０ｍＰａ・ｓの粘性を付与する機能を有する。増粘剤としては、特に制限されないが、寒天、ゼラチン、ペクチン、グアガム、ローカストビーンガム、コンニャクマンナン、キサンタンガム、タマリンドガム、カラギナン、プロピレングリコール、カルボキシメチルセルロースジェランガム、ジェランガム、タラガム、タマリンドシードガム、サイリウムシードガム、アラビアガム、カードラン、プルラン、アルギン酸ナトリウム、トラガントガム、カラヤガム、ビーガム、大豆多糖類等が用いられうる。
これらの増粘剤は、単独で用いても、２種以上を混合して用いてもよい。酸性液状栄養剤中の増粘剤の含有量は、粘度等を考慮して適宜調節される。 (Thickener)
The thickener has a function of imparting an appropriate viscosity to the acidic liquid nutrient, specifically, a viscosity of 10 to 150 mPa · s at 25 ° C. The thickener is not particularly limited, but agar, gelatin, pectin, guar gum, locust bean gum, konjac mannan, xanthan gum, tamarind gum, carrageenan, propylene glycol, carboxymethylcellulose gellan gum, gellan gum, tara gum, tamarind seed gum, psyllium seed Gum, gum arabic, curdlan, pullulan, sodium alginate, tragacanth gum, karaya gum, bee gum, soybean polysaccharide and the like can be used.
These thickeners may be used alone or in admixture of two or more. The content of the thickener in the acidic liquid nutrient is appropriately adjusted in consideration of the viscosity and the like.
　（その他の成分）
　α－アミラーゼ、β－アミラーゼ、グルコアミラーゼ、グルコースイソメラーゼ、トレハロース生成酵素、トレハロース遊離酵素、グルタミナーゼ等の酵素や酵母等が用いられうる。酸性液状栄養剤中の上記食品添加物の含有量は、適用する対象者等によって適宜調節されうる。 (Other ingredients)
Enzymes such as α-amylase, β-amylase, glucoamylase, glucose isomerase, trehalose producing enzyme, trehalose releasing enzyme, glutaminase, yeast and the like can be used. Content of the said food additive in an acidic liquid nutrient can be suitably adjusted with the subject etc. to apply.
　（粘度）
　また、本形態に係る酸性液状栄養剤の粘度は、２５℃において、１０～１５０ｍＰａ・ｓであることが好ましく、２０～１２０ｍＰａ・ｓであることがより好ましい。酸性液状栄養剤の粘度が１５０ｍＰａ・ｓ以下であると、経腸栄養法において、経鼻チューブを流すことができること点から好ましい。当該粘度は、主として、酸性液状栄養剤中の安定剤の含有量を適宜設定することで調節することができる。なお、本明細書において、「粘度」は、実施例に記載された方法で測定された値を採用するものとする。 (viscosity)
Further, the viscosity of the acidic liquid nutrient according to this embodiment is preferably 10 to 150 mPa · s, more preferably 20 to 120 mPa · s at 25 ° C. It is preferable that the viscosity of the acidic liquid nutrient is 150 mPa · s or less because the nasal tube can be flowed in the enteral nutrition method. The viscosity can be adjusted mainly by appropriately setting the content of the stabilizer in the acidic liquid nutrient. In this specification, “viscosity” is a value measured by the method described in the examples.
　（熱量）
　本形態に係る酸性液状栄養剤の熱量は、酸性液状栄養剤の用途によっても異なるが、０．５～２．５ｋｃａｌ／ｇであることが好ましく、水分管理の安全性の観点からは０．５～１．０ｋｃａｌ／ｇであることがより好ましいが、水分制限のある患者や熱傷の患者等へ投与する場合には、１．０～２．５ｋｃａｌ／ｇであることがより好ましい。当該熱量は、糖質、脂質、蛋白質源、および食物繊維等の添加量を適宜設定することで調節することができる。なお、本明細書において、「熱量」とは、実施例に記載された方法で算出された値を採用するものとする。 (Calorie)
The amount of heat of the acidic liquid nutrient according to this embodiment varies depending on the use of the acidic liquid nutrient, but is preferably 0.5 to 2.5 kcal / g, and 0.5 from the viewpoint of the safety of water management. It is more preferably from 1.0 to 1.0 kcal / g, but it is more preferably from 1.0 to 2.5 kcal / g when it is administered to a patient with water limitation or a burn patient. The amount of heat can be adjusted by appropriately setting the amount of sugar, lipid, protein source, dietary fiber, and the like. In the present specification, the value calculated by the method described in the examples is adopted as the “heat amount”.
　（ｐＨ）
　本形態に係る酸性液状栄養剤のｐＨは、３．０～４．０であることが好ましく、３．５～３．８であることがより好ましい。ｐＨが上記範囲にあれば、蛋白質源の安定化を図ることができ、細菌の増殖抑制効果を得られうることから好ましい。なお、本明細書において、「ｐＨ」は、実施例に記載された方法で測定された値を採用するものとする。 (PH)
The pH of the acidic liquid nutrient according to this embodiment is preferably 3.0 to 4.0, and more preferably 3.5 to 3.8. A pH within the above range is preferable because the protein source can be stabilized and an effect of inhibiting bacterial growth can be obtained. In the present specification, “pH” is a value measured by the method described in the examples.
　（平均粒子径）
　本形態に係る酸性液状経腸栄養剤の平均粒子径は、１５μｍ以下であることが好ましく、１０μｍ以下であることがより好ましい。かように平均粒子径が１５μｍ以下で安定化されていることで、栄養剤投与時のチューブ詰まりの発生を減少させることができる。ここで、平均は、後述する実施例の方法により測定された値を採用する。 (Average particle size)
The average particle size of the acidic liquid enteral nutrient according to this embodiment is preferably 15 μm or less, and more preferably 10 μm or less. Thus, since the average particle diameter is stabilized at 15 μm or less, the occurrence of tube clogging during administration of a nutrient can be reduced. Here, the average employ | adopts the value measured by the method of the Example mentioned later.
　（用途）
　本発明の酸性液状栄養剤は、経管栄養投与法、特に好ましくは、経鼻チューブを経由して投与する方法に用いることができる。経鼻チューブを用いた投与は、経口摂取困難であって、腸が機能している高齢者や病者等が対象となりうる。 (Use)
The acidic liquid nutrient of the present invention can be used in a tube feeding method, particularly preferably a method of administration via a nasal tube. Administration using a nasal tube is difficult to take orally, and can be targeted for elderly people or sick people with intestinal function.
　本発明に係る酸性液状栄養剤は、栄養素（糖質、蛋白質源、および脂質）、水分、所定量の有機酸を含み、その栄養素の含有量としては、経管栄養法が目的とする生体が必要とするカロリー、窒素源等の需要を満たすことができる量で含有されることが好ましい。また、酸性液状栄養剤の水分量は、投与する高齢者や患者の状態や水分管理等を考慮して設定することが好ましい。 The acidic liquid nutrient according to the present invention contains nutrients (carbohydrate, protein source, and lipid), water, and a predetermined amount of organic acid. It is preferable to contain in the quantity which can satisfy | fill demands, such as a required calorie and a nitrogen source. Moreover, it is preferable to set the water content of the acidic liquid nutrient in consideration of the conditions of elderly people and patients to be administered, water management, and the like.
　その他、添加されうる成分については、特に制限されず、投与方法、酸性液状経腸栄養剤を適用する高齢者や患者の状態等に応じて適宜設定されうる。また、全身管理を要する患者には、栄養状態を保つために必要とするビタミンやミネラルを含有することが好ましい。消化機能が低下している高齢者等には、酸性液状経腸栄養剤の投与による便秘を改善するために、食物繊維を添加することが好ましい。 Other components that can be added are not particularly limited, and can be appropriately set according to the administration method, the condition of an elderly person or a patient to whom the acidic liquid enteral nutrient is applied, and the like. Moreover, it is preferable that the patient who needs whole body management contains the vitamin and mineral required in order to maintain a nutritional state. In order to improve constipation due to the administration of an acidic liquid enteral nutrient, it is preferable to add dietary fiber to elderly people and the like whose digestive function is lowered.
　本形態の酸性液状栄養剤は、適切な粘度に調整され且つ必要な栄養源をバランスよく配合されているため、加齢に伴い胃が縮小した高齢者、脳血管障害、神経筋障害などにより嚥下・咀嚼能力が低下した患者、意識障害などにより経口摂取が困難である患者、術後の患者等の胃腸管機能の治療用、低栄養状態の治療用、逆流性食道炎予防・治療用、誤嚥性肺炎予防・治療用に適している。投与では下痢や胃食道逆流の恐れがあることから長時間投与を余儀なくされているが、本形態に係る酸性液状栄養剤の使用により、投与中の細菌汚染等のリスクが低減され、患者のＱＯＬ向上および介護・看護現場における作業効率性上昇に非常に役立つことが期待される。 The acidic liquid nutrient of this form is adjusted to an appropriate viscosity and contains the necessary nutrients in a well-balanced manner, so swallowing due to elderly people whose stomach has shrunk with aging, cerebrovascular disorders, neuromuscular disorders, etc.・ For patients with impaired chewing ability, patients who have difficulty in oral intake due to disturbance of consciousness, etc., for the treatment of gastrointestinal tract function, post-surgical patients, etc., for undernutrition, for prevention / treatment of reflux esophagitis, error Suitable for the prevention and treatment of aspiration pneumonia. In the administration, there is a risk of diarrhea and gastroesophageal reflux, but it has been forced to administer for a long time, but the use of the acidic liquid nutrient according to this form reduces the risk of bacterial contamination during administration, and the patient's QOL It is expected to be very useful for improvement and improvement of work efficiency in the nursing / nursing field.
　（酸性液状栄養剤の製造方法）
　本発明に係る酸性液状栄養剤は、公知の方法によって製造することができる。例えば、加温した水に栄養素、所定量の有機酸、およびその他所望とする成分を添加し、撹拌することにより製造することができる。また、加温した水に栄養素を溶解した溶液と、水に有機酸を溶解した溶液とを準備し、栄養素およびその他所望とする成分をいずれかに添加して、２つの溶液を混合、撹拌することで製造することができる。 (Method for producing acidic liquid nutrient)
The acidic liquid nutrient according to the present invention can be produced by a known method. For example, it can be produced by adding nutrients, a predetermined amount of organic acid, and other desired components to warm water and stirring. Also, a solution in which nutrients are dissolved in warm water and a solution in which organic acids are dissolved in water are prepared, and nutrients and other desired components are added to any of them, and the two solutions are mixed and stirred. Can be manufactured.
　得られた酸性液状栄養剤は、例えば、連続殺菌した後に容器に充填して、製品化することができる。当該連続殺菌の方法としては、特に制限されないが、超高温短時間（ＵＨＴ）殺菌、熱水殺菌、バッチ式殺菌、およびこれらの組み合わせが挙げられる。前記殺菌は、短時間で行うことが好ましい。短時間で殺菌を行うことにより、酸性液状栄養剤に含まれる成分の劣化を抑制することができる。 The obtained acidic liquid nutrient can be commercialized by, for example, filling the container after continuous sterilization. Although it does not restrict | limit especially as the method of the said continuous sterilization, Ultra high temperature short time (UHT) sterilization, hot water sterilization, batch type sterilization, and these combination are mentioned. The sterilization is preferably performed in a short time. By performing sterilization in a short time, deterioration of components contained in the acidic liquid nutrient can be suppressed.
　酸性液状栄養剤を充填する容器としては、特に限定されず、公知の容器が用いられうる。当該容器としては、テトラパック、カート缶、ガラス容器、金属缶、アルミパウチ、プラスチック容器等が挙げられる。これらのうち、プラスチック容器を用いることが好ましい。 The container filled with the acidic liquid nutrient is not particularly limited, and a known container can be used. Examples of the container include a tetrapack, a cart can, a glass container, a metal can, an aluminum pouch, and a plastic container. Of these, it is preferable to use a plastic container.
　前記プラスチック容器の原料としては、ポリエチレン（ＰＥ）、ポリプロピレン（ＰＰ）、ポリ塩化ビニル（ＰＶＣ）、ポリ酢酸ビニル（ＰＶＡｃ）、ポリカーボネート（ＰＣ）、ポリブチレンテレフタレート(ＰＢＴ)、ポリエチレンテレフタレート(ＰＥＴ）、ポリエチレンナフタレート（ＰＥＮ）、エチレン－酢酸ビニル共重合体（ＥＶＡ）、エチレン－α－オレフィン共重合体、ポリフルオロカーボン、ポリイミド等を用いることが好ましい。 As a raw material of the plastic container, polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), polyvinyl acetate (PVAc), polycarbonate (PC), polybutylene terephthalate (PBT), polyethylene terephthalate (PET), Polyethylene naphthalate (PEN), ethylene-vinyl acetate copolymer (EVA), ethylene-α-olefin copolymer, polyfluorocarbon, polyimide and the like are preferably used.
　前記プラスチック容器には、さらにポリエチレンテレフタレート（ＰＥＴ）、ポリエチレンナフタレート（ＰＥＮ）、エチレン－ビニルアルコール共重合体（ＥＶＯＨ）、ポリ塩化ビニリデン（ＰＶＤＣ）、ポリアクリロニトリル、ポリビニルアルコール、ポリアミド、ポリエステル等を含むガスバリア性樹脂層；アルミ箔、アルミ蒸着フィルム、酸化ケイ素皮膜、酸化アルミ被膜等のガスバリア性無機層を適宜組み合わせて用いてもよい。当該ガスバリア層を設けることによって、酸素や水蒸気等による酸性液状栄養剤の劣化を防止しうる。 The plastic container further includes polyethylene terephthalate (PET), polyethylene naphthalate (PEN), ethylene-vinyl alcohol copolymer (EVOH), polyvinylidene chloride (PVDC), polyacrylonitrile, polyvinyl alcohol, polyamide, polyester, and the like. Gas barrier resin layer: Gas barrier inorganic layers such as an aluminum foil, an aluminum vapor deposition film, a silicon oxide film, and an aluminum oxide film may be used in appropriate combination. By providing the gas barrier layer, deterioration of the acidic liquid nutrient due to oxygen, water vapor, or the like can be prevented.
　また、前記容器はさらに遮光されていてもよい。当該遮光によって、例えば、酸性液状栄養剤に含有されうるビタミンＡ、ビタミンＢ２、ビタミンＣ、ビタミンＫ等の光による劣化が抑制されうる。 Further, the container may be further shielded from light. By the light shielding, for example, deterioration due to light of vitamin A, vitamin B2, vitamin C, vitamin K and the like which can be contained in the acidic liquid nutrient can be suppressed.
　上記の容器は市販されているものを用いてもよく、例えば、ソフトパウチ（株式会社フジシール製）、ボトルドパウチ（凸版印刷株式会社製）、スパウチ（大日本印刷株式会社製）、チアーパック（株式会社細川洋行製）等が用いられうる。 Commercially available containers may be used, for example, soft pouches (manufactured by Fuji Seal Co., Ltd.), bottled pouches (manufactured by Toppan Printing Co., Ltd.), spouches (manufactured by Dai Nippon Printing Co., Ltd.), cheer packs (co., Ltd.) Hosokawa Yoko) etc. can be used.
　以下、実施例を挙げて本発明を具体的に説明するが、本発明はこれらに限定されるものではない。なお、実施例において「部」または「％」の表示を用いるが、特に断りがない限り「質量部」または「質量％」を表す。 Hereinafter, the present invention will be specifically described with reference to examples, but the present invention is not limited thereto. In addition, although the display of "part" or "%" is used in an Example, unless otherwise indicated, "mass part" or "mass%" is represented.
　（実施例１～１１）
　以下に６０００ｇ仕込み時の調合方法を記す。各原料の配合量は、表１－１および表１－２に示す通りである。１０Ｌのステンレスバケツに調合水２０００ｇを計量し、湯浴にて５０～６０℃に加温した。次いで、消泡剤（アワブレークＧ－１０９（太陽化学株式会社製））、ホエイ蛋白質（ＷＰＣ３９２（Ｆｏｎｔｅｒｒａ社製））、大豆蛋白（プロリーナ（登録商標）９００（不二製油株式会社製））、糖質であるデキストリン（ＴＫ－１６（松谷化学工業株式会社製））、および上白糖を添加した。当該溶液に、脂質、乳化剤であるグリセリン脂肪酸エステル、および大豆多糖類（ソヤファイブ－Ｓ－ＤＮ（不二製油株式会社製））、ペクチンを添加し、混合した。さらに、ビタミンとして、水溶性ビタミンミックスおよび脂溶性ビタミンミックス、ミネラルとして、グルコン酸カルシウム、塩化マグネシウム、塩化カリウム、塩化ナトリウム、リン酸二水素ナトリウムおよびクエン酸三カリウム、酵母として、酵母ミックス、有機酸として、クエン酸およびリンゴ酸、その他に、アスコルビン酸、香料等を適宜添加して撹拌した。得られた混合液が６０００ｇとなるまで水を添加し、均一な状態となるまで溶解分散させた。 (Examples 1 to 11)
The preparation method at the time of 6000g preparation is described below. The blending amount of each raw material is as shown in Table 1-1 and Table 1-2. In a 10 L stainless steel bucket, 2000 g of the prepared water was weighed and heated to 50-60 ° C. in a hot water bath. Antifoaming agent (Awabreak G-109 (manufactured by Taiyo Kagaku Co., Ltd.)), whey protein (WPC392 (manufactured by Fonterra)), soy protein (Prolina (registered trademark) 900 (manufactured by Fuji Oil Co., Ltd.)), sugar Quality dextrin (TK-16 (manufactured by Matsutani Chemical Co., Ltd.)) and super white sugar were added. To the solution, lipid, glycerin fatty acid ester as an emulsifier, soybean polysaccharide (Soya Five-S-DN (manufactured by Fuji Oil Co., Ltd.)), and pectin were added and mixed. Furthermore, as vitamins, water-soluble vitamin mix and fat-soluble vitamin mix, minerals as calcium gluconate, magnesium chloride, potassium chloride, sodium chloride, sodium dihydrogen phosphate and tripotassium citrate, yeast as yeast mix, organic acid As citric acid and malic acid, ascorbic acid, fragrance and the like were appropriately added and stirred. Water was added until the obtained mixed solution became 6000 g, and dissolved and dispersed until a uniform state was obtained.
　得られた溶液は、連続殺菌後、１個当たり２００部となるように口栓付きのアルミパウチに充填し、９０℃で１０分間の容器殺菌処理を行った。前記容器殺菌処理の後、冷却することで、パウチ入りの酸性液状栄養剤を製造した。 The obtained solution was continuously sterilized, filled in an aluminum pouch with a stopper so as to be 200 parts per piece, and subjected to container sterilization at 90 ° C. for 10 minutes. After the container sterilization treatment, an acidic liquid nutrient containing a pouch was produced by cooling.
　総エネルギーは（４Ｋｃａｌ×糖質含量）＋（９Ｋｃａｌ×脂質含量）＋（４Ｋｃａｌ×蛋白質源含量）として計算し、熱量は、試料ｇ当たりのＫｃａｌとして示した。 The total energy was calculated as (4 Kcal × sugar content) + (9 Kcal × lipid content) + (4 Kcal × protein source content), and the calorie was shown as Kcal per g of sample.
　（表１－１）
Figure JPOXMLDOC01-appb-I000001
(Table 1-1)
Figure JPOXMLDOC01-appb-I000001
　（表１－２）
Figure JPOXMLDOC01-appb-I000002
(Table 1-2)
Figure JPOXMLDOC01-appb-I000002
　（比較例１～６）
　以下に６０００ｇ仕込み時の調合方法を記す。各原料の配合量は、表２に示す通りである。１０Ｌのステンレスバケツに調合水２０００ｇを計量し、湯浴にて５０～６０℃に加温した。次いで、消泡剤（アワブレークＧ－１０９：太陽化学株式会社製）、ホエイ蛋白質（ＷＰＣ３９２（Ｆｏｎｔｅｒｒａ社製）、および糖質であるデキストリン（ＴＫ－１６（松谷化学工業株式会社製））、上白糖を添加した。当該溶液に、脂質、乳化剤であるグリセリン脂肪酸エステル、および大豆多糖類（ソヤファイブ－Ｓ－ＤＮ（不二製油株式会社製））を添加し、混合した。さらに、ビタミンとして、水溶性ビタミンミックスおよび脂溶性ビタミンミックス、ミネラルとして、グルコン酸カルシウム、塩化マグネシウム、塩化カリウム、塩化ナトリウム、リン酸二水素ナトリウムおよびクエン酸三カリウム、酵母として、酵母ミックス、有機酸として、クエン酸、その他に、アスコルビン酸、香料等を適宜添加して撹拌した。得られた混合液が６０００ｇとなるまで水を添加し、均一な状態となるまで溶解分散させた。 (Comparative Examples 1 to 6)
The preparation method at the time of 6000g preparation is described below. The amount of each raw material is as shown in Table 2. In a 10 L stainless steel bucket, 2000 g of the prepared water was weighed and heated to 50-60 ° C. in a hot water bath. Subsequently, antifoaming agent (Awabreak G-109: manufactured by Taiyo Kagaku Co., Ltd.), whey protein (WPC392 (manufactured by Fonterra)), and dextrin (TK-16 (manufactured by Matsutani Chemical Co., Ltd.)), super white sugar To the solution, lipid, glycerin fatty acid ester as an emulsifier, and soybean polysaccharide (Soya Five-S-DN (manufactured by Fuji Oil Co., Ltd.)) were added and mixed. Vitamin mix and fat-soluble vitamin mix, as minerals, calcium gluconate, magnesium chloride, potassium chloride, sodium chloride, sodium dihydrogen phosphate and tripotassium citrate, as yeast, yeast mix, as organic acid, citric acid, etc. Ascorbic acid, fragrance and the like were appropriately added and stirred. If liquid water was added until 6000 g, it was dissolved and dispersed into a homogeneous state.
　得られた溶液は、連続殺菌後、１個当たり２００部となるように口栓付きのアルミパウチに充填し、９０℃で１０分間の容器殺菌処理を行った。前記容器殺菌処理の後、冷却することで、パウチ入りの酸性液状栄養剤を製造した。 The obtained solution was continuously sterilized, filled in an aluminum pouch with a stopper so as to be 200 parts per piece, and subjected to container sterilization at 90 ° C. for 10 minutes. After the container sterilization treatment, an acidic liquid nutrient containing a pouch was produced by cooling.
　（表２）
Figure JPOXMLDOC01-appb-I000003
(Table 2)
Figure JPOXMLDOC01-appb-I000003
　得られた酸性液状栄養剤（実施例１～１１、および比較例１～６）について性状を観察し、各種物性を評価した。評価方法は以下の通りである。 The properties of the obtained acidic liquid nutrients (Examples 1 to 11 and Comparative Examples 1 to 6) were observed, and various physical properties were evaluated. The evaluation method is as follows.
　（１）ｐＨは、酸性液状栄養剤を２５℃で２４時静置後、ｐＨ測定器ＭＥＴＴＬＥＲ　ＴＯＬＥＤＯ　ＭＰ２２０（ＭＥＴＴＬＥＲ　ＴＯＬＥＤＯ社）を用いて測定した。 (1) The pH was measured using a pH meter METTLER TOLEDO MP220 (METTLER TOLEDO) after leaving the acidic liquid nutrient at 24 ° C. for 24 hours.
　（２）粘度は、酸性液状栄養剤を２５℃で２４時静置後、Ｂ型回転粘度計（メーカー：ＢＲＯＯＫＦＩＥＬＤ、型式：ＤＶ‐ＩＩ＋Ｐｒｏ、測定条件：回転速度６０ｒｐｍ、測定時間１ｍｉｎ、ローターＮｏ．６１、測定温度　室温（２５℃））を用い測定した。 (2) Viscosity was determined by allowing the acidic liquid nutrient to stand at 25 ° C. for 24 hours, and then rotating the B-type rotational viscometer (manufacturer: BROOKFIELD, model: DV-II + Pro, measurement conditions: rotation speed 60 rpm, measurement time 1 min, rotor 61, measurement temperature: room temperature (25 ° C.)).
　（３）平均粒子径は、レーザー回折型粒度分布計ＳＡＬＤ７０００（株式会社島津製作所）を用いて測定した。 (3) The average particle size was measured using a laser diffraction type particle size distribution analyzer SALD7000 (Shimadzu Corporation).
　（４）安定性は、酸性液状栄養剤を室温で７日間静置後、酸性液状栄養剤の分離状態を目視で確認し、液の安定性を判断した。なお、安定性は、下記の評価基準によって判断した。
○：栄養剤の内容液に分離が見られず、安定性が保たれている。
△：栄養剤の容器底面に僅かな沈降物が見られる。
×：栄養剤の内容液に明らかな分離が見られる。 (4) Stability was determined by visually checking the separated state of the acidic liquid nutrient after standing the acidic liquid nutrient at room temperature for 7 days, and judging the stability of the liquid. The stability was judged according to the following evaluation criteria.
○: No separation was observed in the nutrient solution, and stability was maintained.
Δ: Slight sediment is seen on the bottom of the nutrient container.
X: Clear separation is observed in the nutrient solution.
　（５）沈殿量は、酸性液状栄養剤４０ｇを５０ｍＬファルコンコニカルチューブ（ファルコン社製）に量りとり、遠心分離機　日立ＣＦ９ＲＸ（日立社製）で３０００ｒｐｍ、１０分間、遠心分離を行った後、上澄みを除去し、チューブに残った沈殿物の重量を測定した。
○：沈殿物の量が２．０ｇ以下
△：沈殿物の量が４．０ｇ未満
×：沈殿物の量が４．０ｇ以上 (5) The amount of precipitation was measured by weighing 40 g of acidic liquid nutrient into a 50 mL falcon conical tube (Falcon), centrifuging at 3000 rpm for 10 minutes with a centrifuge Hitachi CF9RX (Hitachi), and then supernatant. And the weight of the precipitate remaining in the tube was measured.
○: The amount of the precipitate is 2.0 g or less Δ: The amount of the precipitate is less than 4.0 g ×: The amount of the precipitate is 4.0 g or more
　（６）チューブ流動性は、試料約２００ｍＬをメスシリンダーではかり、経腸栄養ボトル（テルモ株式会社製）に移しかえ、栄養セット（テルモ株式会社製）、外径８Ｆｒ．、長さ１００ｃｍのフィーディングチューブ（ニプロ社製）を接続し、流速３００ｍＬ／ｈｒで栄養剤の流動性を評価した。
○：チューブ詰まりの発生が無く、全量流しきることが出来る。
△：流動開始後、３０分以内にチューブ詰まりが発生し、全量流しきることが出来ない。
×：粘性が高く、経鼻チューブで流動することが出来ない。 (6) Tube fluidity is measured by measuring about 200 mL of sample with a measuring cylinder and transferring it to an enteral nutrition bottle (manufactured by Terumo Corporation). A feeding tube (manufactured by Nipro Co., Ltd.) having a length of 100 cm was connected, and the fluidity of the nutrient was evaluated at a flow rate of 300 mL / hr.
○: There is no tube clogging and the entire amount can be flowed.
Δ: Tube clogging occurs within 30 minutes after the start of flow, and the entire amount cannot be flowed.
X: Viscosity is high and cannot flow through a nasal tube.
　結果を下記表３に示す。 The results are shown in Table 3 below.
　（表３）
Figure JPOXMLDOC01-appb-I000004
(Table 3)
Figure JPOXMLDOC01-appb-I000004
　実施例１～１１の栄養剤は、例えば、比較例３～６の栄養剤と同程度の粘度であるにも関わらず、沈殿量が少なく、チューブ流動性に優れるものであった。このことから、酸性下における蛋白の安定性は、単に安定剤の添加等に起因するものではなく、所定量の有機酸を添加することが重要であることが理解できる。 For example, the nutrients of Examples 1 to 11 had a small amount of precipitation and excellent tube fluidity despite having the same viscosity as the nutrients of Comparative Examples 3 to 6. From this, it can be understood that the stability of the protein under acidic conditions is not simply caused by the addition of a stabilizer or the like, but it is important to add a predetermined amount of an organic acid.
　以上の結果より、実施例１～１１の栄養剤は、適度な粘度を有し、沈殿量が少なく安定性が良好であった。また、経時的にも安定性が保持され、チューブ流動性が良好であった。 From the above results, the nutrients of Examples 1 to 11 had an appropriate viscosity, a small amount of precipitation, and good stability. In addition, stability was maintained over time, and tube fluidity was good.
　本発明に係る酸性液状栄養剤は、栄養素（糖質、蛋白質源、および脂質）、水分、所定量の有機酸を含むものであって、経管栄養投与法、特に、経鼻チューブを経由して投与される方法に好適に用いられる栄養剤として、産業上の利用可能性を有する。 The acidic liquid nutrient according to the present invention contains nutrients (sugars, protein sources and lipids), moisture, and a predetermined amount of organic acid, and is supplied via a tube feeding method, particularly via a nasal tube. The present invention has industrial applicability as a nutrient that is preferably used in a method to be administered.

Claims (6)

  1. 　糖質、蛋白質源、脂質、および有機酸を含む酸性液状栄養剤であって、前記有機酸の配合比率が、蛋白質源１部に対して、０．１５～０．４５部である酸性液状栄養剤。 An acidic liquid nutrient comprising a sugar, a protein source, a lipid, and an organic acid, wherein the organic acid is mixed in an amount of 0.15 to 0.45 parts per part of the protein source. Agent.
  2. 　２５℃での粘度が１０～１５０ｍＰａ・ｓである請求項１に記載の酸性液状栄養剤。 The acidic liquid nutrient according to claim 1, having a viscosity of 10 to 150 mPa · s at 25 ° C.
  3. 　ｐＨが３．０～４．０である請求項１に記載の酸性液状栄養剤。 The acidic liquid nutrient according to claim 1, having a pH of 3.0 to 4.0.
  4. 　粒度分布計で測定した際の平均粒子径が１５μｍ以下である請求項１に記載の酸性液状栄養剤。 The acidic liquid nutrient according to claim 1, having an average particle size of 15 µm or less as measured by a particle size distribution meter.
  5. 　前記蛋白質源が、ホエイ蛋白質および／または植物性蛋白である請求項１に記載の酸性液状流動食。 The acidic liquid liquid food according to claim 1, wherein the protein source is whey protein and / or vegetable protein.
  6. 　前記植物性蛋白質が、大豆蛋白質である請求項５に記載の酸性液状流動食。 The acidic liquid liquid food according to claim 5, wherein the vegetable protein is soybean protein.
PCT/JP2012/068783 2012-07-25 2012-07-25 Acidic liquid nutrient WO2014016917A1 (en)

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WO2018030284A1 (en) * 2016-08-08 2018-02-15 株式会社明治 Acidic liquid nutritional composition
CN110290708A (en) * 2017-02-28 2019-09-27 株式会社明治 Liquid nutritional composition containing the protein for being originated from milk fermentation ingredient
JP2019210259A (en) * 2018-06-08 2019-12-12 テルモ株式会社 Liquid nutrient supplement composition
JP2020156435A (en) * 2019-03-28 2020-10-01 テルモ株式会社 Liquid nutrient supplement composition
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Cited By (11)

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Publication number Priority date Publication date Assignee Title
JP2016158602A (en) * 2015-03-04 2016-09-05 森永乳業株式会社 High-protein beverage and production method thereof
WO2018030284A1 (en) * 2016-08-08 2018-02-15 株式会社明治 Acidic liquid nutritional composition
CN109688842A (en) * 2016-08-08 2019-04-26 株式会社明治 Acid liquid alimentation composition
JPWO2018030284A1 (en) * 2016-08-08 2019-06-13 株式会社明治 Acidic liquid nutritional composition
JP7218987B2 (en) 2016-08-08 2023-02-07 株式会社明治 Acidic liquid nutritional composition
CN110290708A (en) * 2017-02-28 2019-09-27 株式会社明治 Liquid nutritional composition containing the protein for being originated from milk fermentation ingredient
JP2019210259A (en) * 2018-06-08 2019-12-12 テルモ株式会社 Liquid nutrient supplement composition
JP7171248B2 (en) 2018-06-08 2022-11-15 テルモ株式会社 liquid nutritional composition
JP2020156435A (en) * 2019-03-28 2020-10-01 テルモ株式会社 Liquid nutrient supplement composition
JP7176991B2 (en) 2019-03-28 2022-11-22 テルモ株式会社 liquid nutritional composition
WO2022003027A1 (en) * 2020-07-02 2022-01-06 Fresenius Kabi Deutschland Gmbh Kit for coloring tube feeds

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