WO2013132670A1 - Semi-solidified nutritive agent - Google Patents

Semi-solidified nutritive agent Download PDF

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Publication number
WO2013132670A1
WO2013132670A1 PCT/JP2012/067485 JP2012067485W WO2013132670A1 WO 2013132670 A1 WO2013132670 A1 WO 2013132670A1 JP 2012067485 W JP2012067485 W JP 2012067485W WO 2013132670 A1 WO2013132670 A1 WO 2013132670A1
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Prior art keywords
semi
nutrient
solidified
oil
solidified nutrient
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PCT/JP2012/067485
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French (fr)
Japanese (ja)
Inventor
泰代 谷
中島　裕
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テルモ株式会社
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Publication of WO2013132670A1 publication Critical patent/WO2013132670A1/en

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Definitions

  • the present invention relates to a semi-solidified nutrient.
  • the above-mentioned semi-solidified nutrients in the medical field are mainly applied to sick people, infants, elderly people, etc., and the administration method is roughly divided into oral administration and tube administration.
  • Oral administration is mainly applied to those who have difficulty swallowing with difficulty in mastication and swallowing due to aging or cerebrovascular disorders. People who have difficulty swallowing have difficulty eating a normal meal. In particular, when ingesting water, low-viscosity juice, or the like, the ability to swallow is reduced, and therefore sufficient consideration must be given to backflow and dusk.
  • hospitals have devised methods such as mixing commercially available thickeners with liquid nutrients, tea, water, etc., and giving them after giving appropriate viscosity.
  • the pharyngeal residue may occur due to partial lumps, and the viscosity increases after the thickener is added to the food (stable viscosity). There is a problem that preparation takes time because it takes a little time to prepare.
  • Tube administration is mainly applied to elderly people and patients who cannot be administered orally, and semi-solid nutrients are administered using enteral nutrition.
  • enteral nutrition is a nutritional method aimed at meeting the demand for calories and nutrients (protein sources, minerals, vitamins, etc.) required by the living body, and is the physiological method following oral intake. Is. For this reason, enteral nutrition is usually selected over high calorie infusion therapy (TPN), which is intravenous nutritional supplementation, for patients with intestinal function that cannot be ingested.
  • TPN high calorie infusion therapy
  • examples of the administration method of the nutrient include administration using an oral gastric tube, administration using a nasogastric tube, administration using a gastrostoma, and the like. When used, administration using gastrostomy is primarily selected.
  • the required properties include moderate viscosity, and it is difficult for the nutrients to remain in the tube when it is administered from the gastrostomy through the tube, and it is difficult to contaminate the tube.
  • viscosity it is important to maintain a high viscosity.
  • the above-mentioned semi-solidified nutrient in the food field has a unique texture and can easily and quickly ingest nutrients, so it is mainly applied to portable foods, diet foods and the like.
  • the above-mentioned semi-solidified nutrient in the food field has a unique texture and can easily and quickly ingest nutrients, so it is mainly applied to portable foods, diet foods and the like.
  • Some are sold as nutritional functional foods that further contain nutritional components.
  • Patent Document 1 discloses a semi-solid nutrient obtained by adding agar or whole egg as a semi-solid agent to the enteral nutrient as a semi-solid nutrient applied to the enteral nutrition method.
  • Patent Document 2 discloses a gel enteral nutrient comprising agar and alginic acid and / or a salt thereof.
  • the semi-solidified nutrient prepared by using alginic acid together with agar has a non-uniform semi-solidified nutrient because sodium alginate itself reacts with calcium ions to form aggregates. It is easy to become an agent.
  • an object of the present invention is to provide a semi-solidified nutrient in which the occurrence of water separation is suppressed.
  • the present inventors have found that the above-mentioned problems can be solved by adding a predetermined amount of agar and a predetermined amount of thickener to the semi-solidified nutrient, and the present invention has been completed. I came to let you.
  • the present invention includes a nutrient containing a carbohydrate and protein source, water, agar, at least one thickener selected from the group consisting of pectin, locust bean gum, soybean polysaccharide, and guar gum,
  • a semi-solidified nutrient containing at least the agar content is 0.1 to 0.8% by mass relative to the total nutrient amount, and the thickener content is relative to the total nutrient amount It is a semi-solidified nutrient that is 0.2 to 1.0% by mass.
  • the present invention provides a semi-solidified nutrient in which the occurrence of water separation is suppressed.
  • the semi-solidified nutrient according to the present invention is at least one selected from the group consisting of nutrients including carbohydrates and protein sources, moisture, agar, pectin, locust bean gum, soybean polysaccharide, and guar gum.
  • Nutrients essentially include carbohydrate and protein sources.
  • the nutrient may further contain at least one selected from the group consisting of lipids, vitamins, minerals, and dietary fiber as an optional component.
  • the total amount of nutrients in the semi-solidified nutrient is preferably 10 to 50% by mass, and more preferably 20 to 35% by mass.
  • Carbohydrates are also called carbohydrates and serve as energy sources.
  • the carbohydrate that can be used is not particularly limited as long as it is absorbed into a living body and becomes an energy source, and examples thereof include monosaccharides, disaccharides, and polysaccharides.
  • monosaccharides include glucose (glucose), fructose (fructose), galactose and the like.
  • disaccharide include sucrose (sucrose), lactose (lactose), maltose (malt sugar), isomaltose, trehalose and the like.
  • Specific examples of the polysaccharide include starch (amylose, amylopectin), dextrin and the like. Of these, dextrin is preferably used.
  • Dextrin is a general term for substances in which several ⁇ -glucoses are polymerized by glycosidic bonds, and can be obtained by hydrolysis of starch. Since dextrin has a slow degradation rate in the small intestine and is slowly absorbed, it can prevent a rapid increase in blood sugar. Moreover, by using dextrin, the osmotic pressure of the semi-solidified nutrient can be reduced, and osmotic diarrhea can be prevented.
  • the dextrin either a high molecular dextrin having a high degree of polymerization of ⁇ -glucose or a low molecular dextrin having a low degree of polymerization of ⁇ -glucose may be used, but a high molecular dextrin capable of further reducing the osmotic pressure should be used. Is preferred.
  • the low molecular dextrin is also called maltodextrin and is usually a polymer of 3 to 5 ⁇ -glucose.
  • Dextrin may be prepared by itself or a commercially available product may be used.
  • known starches such as corn, waxy corn, wheat, rice, waxy rice, waxy miro, beans (broad beans, mung beans, red beans, etc.), potatoes, sweet potatoes, tapioca, etc. It can be prepared by hydrolysis by a known method.
  • examples of commercially available dextrin include TK-16 (manufactured by Matsutani Chemical Industry Co., Ltd.) and the like, which can be preferably used.
  • the above carbohydrates may be used alone or in combination of two or more.
  • the content of the saccharide in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied, but is preferably 5 to 25% by mass with respect to the total amount of the semi-solidified nutrient.
  • the protein source is not particularly limited, and known proteins can be used. For example, amino acids, peptides, plant proteins, animal proteins and the like can be mentioned.
  • Amino acids include essential amino acids such as valine, leucine, isoleucine, lysine, methionine, phenylalanine, threonine, tryptophan, histidine; and glycine, alanine, serine, cysteine, asparagine, glutamine, proline, tyrosine, aspartic acid, glutamic acid, arginine, etc.
  • essential amino acids such as valine, leucine, isoleucine, lysine, methionine, phenylalanine, threonine, tryptophan, histidine
  • glycine alanine, serine, cysteine, asparagine, glutamine, proline, tyrosine, aspartic acid, glutamic acid, arginine, etc.
  • modified amino acids such as 4-hydroxyproline, 5-hydroxylysine, ⁇ -carboxyglutamic acid, O-phosphoserine, O-phosphotyrosine, N-acetylserine, N ⁇ -methylarginine, pyroglutamic acid, M-formylmethionine; ornithine Special amino acids such as citrulline, ⁇ -aminobutyric acid (GABA), thyroxine, S-adenylmethionine may also be included.
  • the amino acids may be stereoisomers (enantiomers, diastereomers), positional isomers, or a mixture thereof.
  • the amino acid may be in the form of an inorganic acid salt (hydrochloride or the like), an organic acid salt (acetate or the like), or an ester body (methyl ester or the like) that can be hydrolyzed in vivo.
  • the peptide one obtained by polymerizing two or more of the above amino acids via a peptide bond (amide bond) can be used.
  • the peptide may be a dipeptide, a tripeptide, an oligopeptide (having about 10 amino acids), or a polypeptide (having several tens to several hundred amino acids).
  • Some oligopeptides such as lactotripeptides, casein decapeptides, valyltyrosine-containing sadden peptides and the like may have health functions such as antihypertensive action.
  • plant proteins examples include proteins contained in grains such as rice and beans such as soybeans and tofu.
  • soy protein it can have health functions, such as combining with a bile acid and promoting the excretion of cholesterol.
  • animal proteins examples include proteins contained in eggs, meat, seafood, milk and the like.
  • whey protein made from milk (whey) as a raw material, casein protein contained in milk, and soybean protein are preferably used, and whey protein is more preferably used.
  • whey protein examples include whey protein concentrate (WPC), whey protein isolate (WPI), hydrolyzed whey peptide (WPH) and the like.
  • WPC whey protein concentrate
  • WPI whey protein isolate
  • WPH hydrolyzed whey peptide
  • Commercially available products such as WPC, WPI, and soy protein may be used.
  • WPI18855 (manufactured by Fontera), WPI18822 (manufactured by Fontera), WPI1895 (manufactured by Fontera), WPC392 (manufactured by Fontera) ), WPC80 (manufactured by Fontera), WPC7009 (manufactured by Fontera), WPC164 (manufactured by Fontera), WPC162 (manufactured by Fontera), WPC132 (manufactured by Fontera), WPC472 (manufactured by Fontera), Prolina 900 (Fuji Oil) New Fuji Pro 3000 (Fuji Oil Co., Ltd.), New Fuji Pro 1700N (Fuji Oil Co., Ltd.) and the like.
  • the above protein sources may be used alone or in combination of two or more.
  • the content of the protein source in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied, but is preferably 1 to 18% by mass with respect to the total amount of the semi-solidified nutrient.
  • Lipids can be a source of energy, biomembrane constituents, steroid hormones and bile acids.
  • the lipid that can be used is not particularly limited, and examples thereof include saturated fatty acids, unsaturated fatty acids, vegetable oils, animal fats and oils, and fish oils.
  • saturated fatty acids examples include caprylic acid, capric acid, lauric acid, palmitic acid, stearic acid and the like.
  • unsaturated fatty acids include oleic acid, palmitoleic acid, linoleic acid, arachidonic acid, ⁇ -linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA).
  • EPA and DHA it can have health functions, such as a blood cholesterol raise inhibitory effect and a neutral fat rise inhibitory effect.
  • Vegetable oils include coconut oil, corn oil, cottonseed oil, olive oil, palm oil, palm kernel oil, peanut oil, rapeseed oil, safflower oil (safflower oil), sesame oil, soybean oil, sunflower oil, almond oil, cashew oil, hazelnut Oil, macadamia nut oil, mongolian oil, pecan oil, pine nut oil, pistachio oil, walnut oil, gourd seed oil, buffalo pumpkin oil, pumpkin seed oil, watermelon seed oil, amaranth oil, apricot oil, apple oil, argan oil , avocado oil, babas oil, moringa oil, borneo oil, cape chestnut oil, cocoa butter, carob oil, kofne palm oil, coriander seed oil, dica oil, flaxseed oil, grape seed oil, hemp oil, kapok seed oil, lale mantia oil , Marula oil, Meadow foam oil, mustard oil, Tsumug butter, okra oil, papaya oil, perilla oil
  • Animal fats include lard (pig fat), head (tallow), milk fat, and the like.
  • Fish oil includes fish oil such as mackerel, salmon, yellowtail, sardine, saury.
  • linoleic acid and ⁇ -linolenic acid that cannot be synthesized in vivo by humans, or lipids containing these.
  • lipids may be used alone or in combination of two or more.
  • the lipid content in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied, but is preferably 0 to 10% by mass with respect to the total amount of the semi-solidified nutrient.
  • vitamin Vitamins are a general term for organic compounds other than carbohydrates, protein sources, and lipids that are necessary to maintain the nutritional state of living organisms.
  • Vitamin A retinol
  • vitamin D ergocalciferol, cholecalciferol
  • vitamin E tocopherol, tocotrienol
  • vitamin K phytoquinone, menaquinone
  • vitamin B1 thiamine
  • vitamin B2 Roboflavin
  • vitamin B3 niacin
  • vitamin B5 pantothenic acid
  • vitamin B6 pyridoxal, pyridoxamine, pyridoxine
  • vitamin B7 biotin
  • vitamin B9 folic acid
  • vitamin B12 cyanocobalamin, hydroxocobalamin
  • vitamin C water-soluble vitamins such as (ascorbic acid).
  • the content of vitamins in the semi-solidified nutrient can be adjusted as appropriate by the subject to be applied. Normally, fat-soluble vitamins are added in an amount that does not cause excess disease, and water-soluble vitamins are not limited in the amount added.
  • the preferable content of each vitamin per 100 g of the semi-solidified nutrient is as follows.
  • Vitamin A preferably 0 to 3000 ⁇ g, more preferably 20 to 200 ⁇ g Vitamin D: preferably 0.1-50 ⁇ g, more preferably 0.1-5.0 ⁇ g Vitamin E: preferably 0.2 to 800 mg, more preferably 1 to 10 mg Vitamin K: preferably 0.5 to 1000 ⁇ g, more preferably 2 to 50 ⁇ g Water-soluble vitamins; Vitamin B1: preferably 0.01 to 40 mg, more preferably 0.1 to 5 mg Vitamin B2: preferably 0.01-20 mg, more preferably 0.05-5 mg Niacin: preferably 0.1 to 300 mg NE, more preferably 0.5 to 30 mg NE Pantothenic acid: preferably 0.1 to 55 mg, more preferably 0.2 to 10 mg Vitamin B6: preferably 0.01-60 mg, more preferably 0.1-10 mg Biotin: preferably 0.1 to 1000 ⁇ g, more preferably 1 to 100 ⁇ g Folic acid: preferably 1-1000 ⁇ g, more preferably 10-200 ⁇ g Vitamin B12: preferably 0.01-100 ⁇ g, more
  • Minerals include quasi-major elements such as sodium, potassium, calcium, phosphorus and magnesium; essential trace elements such as iron, zinc, copper, iodine, manganese, selenium, chromium and molybdenum. These minerals may be used alone or in combination of two or more.
  • the content of mineral in the semi-solidified nutrient can be adjusted as appropriate by the subject to be applied.
  • the preferable content of each mineral per 100 g of the semi-solidified nutrient is as follows.
  • Dietary fiber can have functions such as reduced nutrient utilization, reduced plasma cholesterol, improved blood glucose response, improved colon function, and prevention of colon cancer.
  • dietary fiber may be fermented by intestinal bacteria and converted to short chain fatty acids, carbon dioxide gas, hydrogen gas, methane gas, and the like. Among these, since short chain fatty acids are absorbed in the large intestine, dietary fiber may be an energy source.
  • the dietary fiber is not particularly limited, but insoluble dietary fiber such as cellulose, hemicellulose, lignin, insoluble pectin, chitin, chitosan, indigestible dextrin, polydextrose, guar gum degradation product, psyllium seed coat, low molecular weight sodium alginate; Water-soluble dietary fiber such as sex pectin, guar gum, konjac mannan, glucomannan, alginic acid, agar, chemically modified polysaccharide, polydextrose, indigestible oligosaccharide, maltitol, inulin, carrageenan, wheat bran, pine fiber C, etc. Can be mentioned. These dietary fibers may be used alone or in combination of two or more.
  • the content of dietary fiber in the semi-solidified nutrient can be adjusted as appropriate by the subject to be applied.
  • the semi-solidified nutrient according to the present invention contains moisture.
  • the water content in the semi-solidified nutrient can be adjusted as appropriate depending on the subject to be applied and the desired viscosity, but is preferably 40 to 90% by mass with respect to the total amount of the semi-solidified nutrient.
  • the semi-solidified nutrient according to this embodiment contains 0.1 to 0.8% by mass, preferably 0.3 to 0.6% by mass of agar, based on the total amount of the semi-solidified nutrient.
  • the semi-solidified nutrient contains agar with the above-mentioned content together with a predetermined amount of thickener, water retention can be improved and water separation can be suppressed.
  • Agar is a product obtained by freezing and drying mucus of red algae such as agaric and tiger beetle, and contains polysaccharides such as agarose and agaropectin as a main component.
  • the agarose and agaropectin have a structure in which galactose and 3,6-andehydrogalactose are alternately polymerized.
  • Agar may have different properties depending on the degree of polymerization and molecular weight of agarose and agaropectin, the content of sulfate groups and pyruvate groups in the agar, etc., but it is not particularly limited in the semi-solidified nutrient according to this embodiment. Any of these may be used.
  • the semi-solidified nutrient tends to be in a jelly shape close to a solid.
  • the semi-solidified nutrient tends to be a paste that is close to a liquid.
  • Examples of commercially available products include Ultra Agar UX30 (manufactured by Ina Food Industry Co., Ltd.), Ultra Agar UX100 (manufactured by Ina Food Industry Co., Ltd.), Ultra Agar AX-30 (manufactured by Ina Food Industry Co., Ltd.), and Ultra Agar AX-100 ( Ina Food Industry Co., Ltd.), Ultra Agar BX-30 (Ina Food Industry Co., Ltd.), Ultra Agar BX-100 (Ina Food Industry Co., Ltd.) and the like can be used.
  • the semi-solidified nutrient according to the present invention includes at least one thickener selected from the group consisting of pectin, locust bean gum, soybean polysaccharide, and guar gum.
  • the content of at least one thickener selected from the group consisting of pectin, locust bean gum, soybean polysaccharide, and guar gum in the semi-solidified nutrient is 0.2 with respect to the total amount of the semi-solidified nutrient. It is -1.0 mass%. If the content of the thickener is less than 0.2% by mass, it is difficult to maintain water retention and water separation occurs. When the content of the thickener exceeds 1.0% by mass, stickiness tends to increase. The content is preferably 0.3 to 0.6% by mass.
  • the semi-solidified nutrient according to this embodiment may further contain a thickener other than the above thickener.
  • thickeners examples include, but are not limited to, gelatin, konjac mannan, xanthan gum, tamarind gum, carrageenan, propylene glycol, carboxymethylcellulose gellan gum, gellan gum, tara gum, tamarind seed gum, psyllium seed gum, gum arabic, curd Orchid, pullulan, sodium alginate, tragacanth gum, karaya gum, bee gum and the like can be used. These thickeners may be used alone or in admixture of two or more.
  • the semi-solidified nutrient according to this embodiment may further contain other known components such as health functional ingredients, food additives, thickeners and the like.
  • a health function component is a component that exhibits a certain function for a living body when ingested.
  • the health function component include indigestible oligosaccharide, sugar alcohol, calcium citrate malate (CCM) and casein phosphopeptide (CPP), chitosan, L-arabinose, guava leaf polyphenol, wheat albumin, beans
  • CCM calcium citrate malate
  • CPP casein phosphopeptide
  • chitosan L-arabinose
  • guava leaf polyphenol guava leaf polyphenol
  • wheat albumin beans
  • drum extract diacylglycerol, diacylglycerol plant sterol, soy isoflavone, and milk basic protein.
  • Indigestible oligosaccharides are saccharides that are not as large in molecular weight as polysaccharides (about 300 to 3000) among compounds in which monosaccharides are linked by glycosidic bonds.
  • the indigestible oligosaccharides are not degraded by human digestive enzymes, but those digested by human digestive enzymes can be included in the aforementioned carbohydrates. Ingestion of indigestible oligosaccharides can provide a bowel regulation effect.
  • the indigestible oligosaccharide is not particularly limited, and examples thereof include xylooligosaccharide, fructooligosaccharide, soybean oligosaccharide, isomaltooligosaccharide, dairy oligosaccharide, lactulose, and galactooligosaccharide. These indigestible oligosaccharides may be used alone or in combination of two or more.
  • the content of indigestible oligosaccharides in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied.
  • Sugar alcohol is a kind of sugar produced by reduction of the carbonyl group of aldose or ketose, and it is not easily absorbed from the small intestine into the body and does not easily become calories. Sugar alcohol is difficult to be metabolized to acid by oral bacteria and can prevent plaque formation. The sugar alcohol can be used as a low calorie sweetener.
  • sugar alcohols examples include erythritol, maltitol, palatinose and the like. These sugar alcohols may be used alone or in admixture of two or more.
  • the content of sugar alcohol in the semi-solidified nutrient can be adjusted as appropriate by the subject to be applied.
  • CCM and CPP can promote calcium absorption and promote bone formation.
  • the CCM and CPP may be used alone or in combination.
  • CCM and CPP are preferably used in combination with calcium.
  • the content of CCM and CPP in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied.
  • Food additive The food additive is used for the purpose of processing or storing the food by adding, mixing, moistening or other methods to the food.
  • food additives for example, zinc gluconate and copper gluconate, ascorbic acid 2-glucoside, cyclodextrin, antioxidant, colorant, sweetener, pH adjuster, acidulant, An emulsifier, a fragrance
  • Zinc gluconate and copper gluconate are gluconates that utilize high chelating ability of gluconate with heavy metal ions. Since it becomes easy to be absorbed when it is made into the form of gluconate, zinc and copper can be absorbed effectively.
  • the zinc gluconate and copper gluconate may be used alone or in combination.
  • the content of zinc gluconate and copper gluconate in the semi-solidified nutrient can be adjusted as appropriate by the subject to be applied.
  • Ascorbic acid 2-glucoside is a compound in which glucose is bonded to the hydroxyl group at the 2-position of vitamin C (ascorbic acid) in an ⁇ -coordination, and is not subject to oxygen attack. It is a vitamin C derivative with high stability. Vitamin C can be efficiently absorbed by ascorbic acid 2-glucoside.
  • the content of ascorbic acid 2-glucoside in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied.
  • Cyclodextrin is a cyclic oligosaccharide having a cyclic structure in which glucose is bound by a glucoside bond. Those consisting of 6 glucoses are called ⁇ -cyclodextrin, those consisting of 7 glucoses are called ⁇ -cyclodextrin, and those consisting of 8 glucoses are called ⁇ -cyclodextrin. Cyclodextrins can have functions such as an allergy suppressing effect, a blood sugar level increase suppressing effect, and an emulsifying action. The said cyclodextrin may be used independently or may be used in mixture of 2 or more types.
  • the content of cyclodextrin in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied.
  • Antioxidant has the function of preventing alteration of semi-solidified nutrient due to oxidation.
  • the antioxidant is not particularly limited, but ascorbic acid and its sodium salt, erythorbic acid and its sodium salt, and the like can be used. These antioxidants may be used alone or in combination of two or more.
  • Colorant has a function of beautifying the semi-solidified nutrient.
  • dye Edible red No. 2, No. 3, No. 40, No. 102, No. 104, No. 105, and No. 106, Edible blue No. 1 and No. 2, Edible yellow No. 4 And No. 5, Edible Green No.
  • ⁇ -carotene water-soluble anato, chlorophyll derivatives (chlorophyll a, chlorphyll b, copper chlorophyll, copper chlorophyllin sodium, iron chlorophyllin sodium, etc.), riboflavin, iron sesquioxide, titanium dioxide Safflower yellow pigment, cochineal pigment, gardenia yellow pigment, turmeric pigment, red cabbage pigment, beet red, grape skin pigment, paprika pigment, caramel and the like can be used. These colorants may be used alone or in admixture of two or more.
  • Sweetener The sweetener has a function of imparting sweetness to the semi-solidified nutrient.
  • the sweetener is not particularly limited, but saccharin and its sodium salt, xylitol, aspartame, sucralose, acesulfame potassium, dulcin, cyclamate, neotame, trehalose, erythritol, maltose, para-north, sorbitol, licorice extract
  • saccharin and its sodium salt xylitol, aspartame, sucralose, acesulfame potassium, dulcin, cyclamate, neotame, trehalose, erythritol, maltose, para-north, sorbitol, licorice extract
  • Stevia processed sweeteners thaumatin, curculin, disodium glycyrrhizinate and the like can be used. These sweeteners may be used alone or in combination of two or more.
  • the pH adjuster has a function of adjusting the pH of the semi-solidified nutrient.
  • the pH adjuster is not particularly limited, and citric acid, gluconic acid, succinic acid, potassium carbonate, sodium hydrogen carbonate, carbon dioxide, lactic acid, sodium lactate, sodium citrate, adipic acid and the like can be used. These pH adjusters may be used alone or in combination of two or more.
  • Acidulant has functions such as imparting acidity to the nutrient, preventing oxidation of the food, and adjusting the pH.
  • the acidulant is not particularly limited, but acetic acid, citric acid, succinic acid, lactic acid, malic acid, tartaric acid, gluconic acid, phosphoric acid and the like can be used. These acidulants may be used alone or in combination of two or more.
  • Emulsifier has functions such as improving the solubility of oil-soluble components such as lipids in water.
  • the emulsifier is not particularly limited, and examples include natural emulsifiers such as lecithin, saponin, and casein sodium; and synthetic emulsifiers such as glycerin fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, and sucrose fatty acid ester. These emulsifiers may be used alone or in combination of two or more.
  • the fragrance has a function of flavoring and smelling the semi-solidified nutrient.
  • the fragrance is not particularly limited, but acetophenone, ⁇ -amylcinnamaldehyde, anisaldehyde, benzaldehyde, benzyl acetate, benzyl alcohol, cinnamaldehyde, cinnamic acid, citral, citronellal, citronellol, decanal, decanol, ethyl acetoacetate, Ethyl cinnamate, ethyl decanoate, ethyl vanillin, eugenol, geraniol, isoamyl acetate, isoamyl butyrate, isoamyl phenyl acetate, dl-menthol, l-menthol, methyl salicylate, piperonal, propionic acid, terpineol, vanillin, d-borneol, etc. Can be mentioned. These fragrances may be used alone or in combination of two or more.
  • enzymes such as ⁇ -amylase, ⁇ -amylase, glucoamylase, glucose isomerase, trehalose producing enzyme, trehalose releasing enzyme, glutaminase, yeast and the like can be used.
  • the content of the above-mentioned food additive in the semi-solidified nutrient can be adjusted as appropriate by the target person to be applied.
  • the semi-solidified nutrient according to this embodiment suppresses generation of water separation by containing at least one thickener selected from the group consisting of a predetermined amount of pectin, locust bean gum, soybean polysaccharide, and guar gum. be able to.
  • the water separation rate of the semi-solidified nutrient is preferably 1% or less, and more preferably 0.5% or less. A water separation rate of 1% or less is preferable because the viscosity and shape retention of a semi-solidified nutrient that is suitably set according to the application can be maintained.
  • the value measured by the method described in the Example shall be employ
  • the viscosity of the semi-solidified nutrient according to this embodiment is preferably 10,000 to 50,000 mPa ⁇ s, more preferably 15,000 to 30,000 mPa ⁇ s at 25 ° C. It is preferable that the semi-solidified nutrient has a viscosity of 10,000 mPa ⁇ s or more because gastroesophageal reflux, aspiration pneumonia, and the like can be less likely to occur. On the other hand, it is preferable that the viscosity of the semi-solidified nutrient is 50000 mPa ⁇ s or less because digestion can be facilitated.
  • the viscosity can be adjusted mainly by the content of at least one thickener selected from the group consisting of pectin, locust bean gum, soybean polysaccharide, and guar gum in the semi-solidified nutrient.
  • at least one thickener selected from the group consisting of pectin, locust bean gum, soybean polysaccharide, and guar gum in the semi-solidified nutrient.
  • viscosity is a value measured by the method described in the examples.
  • the calorific value of the semi-solidified nutrient according to this embodiment varies depending on the use of the semi-solidified nutrient, but is preferably 0.5 to 2.5 kcal / g, and is 0 from the viewpoint of water management safety. More preferably, it is 0.5 to 1.0 kcal / g, but more preferably 1.0 to 2.5 kcal / g when it is administered to a patient with water limitation or a burn patient.
  • heat amount can be adjusted by setting suitably addition amount, such as saccharide
  • the pH of the semi-solidified nutrient according to this embodiment is preferably 3.0 to 4.5, and more preferably 3.5 to 3.9. If pH is in the said range, since the proliferation of bacteria can be suppressed and a refreshing feeling can be obtained, it is preferable.
  • the said pH can be adjusted by setting suitably addition amount, such as a pH adjuster and a sour agent.
  • pH is a value measured by the method described in the examples.
  • the semi-solidified nutrient described above can be applied to fields such as medicine and food.
  • the administration method of the semi-solidified nutrient in enteral nutrition is not particularly limited, but is usually oral administration or administration using gastrostomy. Oral administration can be applied to elderly people and patients who have difficulty in chewing and swallowing and whose intestines are functioning. In addition, administration using a gastrostoma can be targeted to elderly people or patients who have difficulty in oral intake and have a functioning intestine.
  • the semi-solidified nutrient includes nutrients, moisture, and at least one thickener selected from the group consisting of a predetermined amount of pectin, locust bean gum, soybean polysaccharide, and guar gum. It is preferable that the content of the nutrient is contained in an amount capable of satisfying demands such as calories and nitrogen sources required by the living body intended for enteral nutrition. Moreover, it is preferable to set the water content of the semi-solidified nutrient in consideration of the conditions of elderly people and patients to be administered, water management, and the like.
  • the components that can be added in addition to the components essential to the semi-solidified nutrient according to the present embodiment are not particularly limited, and are appropriately set according to the administration method, the state of the elderly or patient to which the semi-solidified nutrient is applied Can be done.
  • the state of the elderly or patient to which the semi-solidified nutrient is applied Can be done.
  • sweeteners, acidulants, fragrances and the like from the viewpoint of improving the taste at the time of ingestion, and in the case of administration using a gastrostoma, from the viewpoint of preventing discomfort at the time of getp.
  • the patient who needs whole body management contains the vitamin and mineral required in order to maintain a nutritional state.
  • the semi-solidified nutrient since the occurrence of water separation is suppressed, the semi-solidified nutrient is absorbed with a desired kinetics, and it may be difficult to cause gastroesophageal reflux and aspiration pneumonia. .
  • preservability and handling at the time of injection of a gastrostomy tube in administration using a gastrostoma can be improved.
  • the semi-solidified nutrient according to the present embodiment can adjust the viscosity, calorie, pH and the like while suppressing the occurrence of water separation, for example, administration using a gastrostoma by adjusting the viscosity Can improve the adhesion to the gastrostomy tube and the digestibility of the semi-solidified nutrient.
  • administration using a gastrostoma by adjusting the viscosity Can improve the adhesion to the gastrostomy tube and the digestibility of the semi-solidified nutrient.
  • by adjusting the amount of heat nutrition management of elderly people and patients to which the semi-solidified nutrient is applied can be facilitated.
  • preservability and a refreshing feeling can be improved by adjusting pH.
  • the viscosity, heat amount, pH and the like can be controlled by appropriately adjusting the components in the semi-solidified nutrient and the content thereof.
  • production of water separation can be suppressed by including a predetermined amount of thickener.
  • the semi-solidified nutrient can be applied to a favorite food, for example.
  • the semi-solidified nutrient according to this embodiment includes nutrients, moisture, and a predetermined amount of thickener.
  • the content of the nutrient is preferably selected as appropriate according to the intended consumer. That is, when it is set as a diet food, the content of nutrients can be set low, and when it is set as a nutritionally adjusted food that replaces meals, the content of nutrients can be set high.
  • the water content of the semi-solidified nutrient can be selected as appropriate in consideration of the texture and whereabouts of the food to be produced.
  • the components that can be added in addition to the components essential to the semi-solidified nutrient according to the present invention are not particularly limited, and can be appropriately selected according to the food to be manufactured.
  • a pH adjuster to make the pH acidic.
  • CCM calcium citrate malate
  • CCPP casein phosphopeptide
  • the semi-solidified nutrient according to this embodiment since the occurrence of water separation can be suppressed, energy and the like can be suitably supplied, and the food can be excellent in palatability.
  • the semi-solidified nutrient according to the present embodiment can adjust the viscosity, calorie, pH and the like while suppressing the occurrence of water separation, various product development can be performed according to the purpose. For example, by adjusting the viscosity, a semi-solidified nutrient having a different texture can be produced. Moreover, the semi-solidification nutrient according to a request can be manufactured by adjusting calorie
  • the semi-solidified nutrient according to this embodiment can be produced by a known method. For example, it can be produced by adding nutrients, agar, thickener and other desired components to warm water and stirring. Also, prepare a solution in which agar is dissolved in warm water and a solution in which a thickener is dissolved in warm water, add nutrients and other desired ingredients to any of the two solutions, It can be produced by mixing and stirring.
  • the obtained semi-solidified nutrient can be commercialized by, for example, filling a container after continuous sterilization. Although it does not restrict
  • UHT Ultra high temperature short time
  • the sterilization is preferably performed in a short time. By performing sterilization in a short time, deterioration of components contained in the semi-solidified nutrient can be suppressed.
  • the container for filling the semi-solidified nutrient is not particularly limited, and a known container can be used.
  • the container include a tetrapack, a cart can, a glass container, a metal can, an aluminum pouch, and a plastic container. Of these, it is preferable to use a plastic container.
  • polyethylene polyethylene
  • PP polypropylene
  • PVC polyvinyl chloride
  • PVAc polyvinyl acetate
  • PC polycarbonate
  • PBT polybutylene terephthalate
  • PET polyethylene terephthalate
  • PEN Polyethylene naphthalate
  • EVA ethylene-vinyl acetate copolymer
  • EVA ethylene- ⁇ -olefin copolymer
  • polyfluorocarbon polyimide and the like
  • the plastic container further includes polyethylene terephthalate (PET), polyethylene naphthalate (PEN), ethylene-vinyl alcohol copolymer (EVOH), polyvinylidene chloride (PVDC), polyacrylonitrile, polyvinyl alcohol, polyamide, polyester, and the like.
  • Gas barrier resin layer Gas barrier inorganic layers such as an aluminum foil, an aluminum vapor deposition film, a silicon oxide film, and an aluminum oxide film may be used in appropriate combination. By providing the gas barrier layer, deterioration of the semi-solidified nutrient due to oxygen, water vapor, or the like can be prevented.
  • the container may be further shielded from light.
  • the light shielding for example, deterioration due to light such as vitamin A, vitamin B2, vitamin C, and vitamin K that can be contained in the semi-solidified nutrient can be suppressed.
  • the above-mentioned container may use what is marketed, for example, a soft pouch (made by Fuji Seal Co., Ltd.), a bottled pouch (made by Toppan Printing Co., Ltd.), a spouch (made by Dai Nippon Printing Co., Ltd.), a cheer pack (Co., Ltd.) Hosokawa Yoko) etc. can be used.
  • a soft pouch made by Fuji Seal Co., Ltd.
  • a bottled pouch made by Toppan Printing Co., Ltd.
  • a spouch made by Dai Nippon Printing Co., Ltd.
  • a cheer pack Co., Ltd. Hosokawa Yoko
  • Example 1 1200 parts of the prepared water was put in a 5 L stainless steel bucket and heated to 80 ° C. or higher in a hot water bath. Next, 15 parts of Ultra Agar UX100 (manufactured by Ina Food Industry Co., Ltd.), 2 parts of pectin, 6 parts of locust bean gum, 2.5 parts of soybean polysaccharide, and 1 part of guar gum were added and dissolved. The obtained solution was cooled to 50 to 60 ° C., 150 parts of WPC392 (whey protein concentrate: manufactured by Fonterra) as a protein source, and TK-16 (dextrin: manufactured by Matsutani Chemical Co., Ltd.) as a carbohydrate 400 Parts were added.
  • WPC392 whey protein concentrate: manufactured by Fonterra
  • TK-16 dextrin: manufactured by Matsutani Chemical Co., Ltd.
  • the obtained solution was subjected to continuous sterilization, filled in an aluminum pouch with a stopper so that the amount was 200 parts per piece, and subjected to container sterilization at 90 ° C. for 10 minutes. After the container sterilization treatment, a semi-solidified nutrient containing a pouch was produced by cooling.
  • Example 2 A semi-solid nutrient was produced in the same manner as in Example 1 except that the protein source was changed to 120 parts of WPC392 (whey protein concentrate: manufactured by Fonterra) and 30 parts of soy protein.
  • WPC392 whey protein concentrate: manufactured by Fonterra
  • Example 3 20 parts agar added, 4 parts pectin added, 10 parts locust bean gum added, 2.5 parts soy polysaccharide added, and 1.5 parts guar gum added A semi-solidified nutrient was produced in the same manner as in Example 1 except that.
  • Example 1 40 parts of agar, 1.5 parts of pectin, 0.5 parts of locust bean gum, 2 parts of soy polysaccharide, and 0.5 parts of guar gum A semi-solidified nutrient was produced in the same manner as in Example 1 except that the content was changed to.
  • the evaluation of the water separation rate is based on a semi-solidified nutrient that was allowed to stand for 24 hours at 25 ° C and a semi-solidified nutrient that was subjected to an accelerated test (stable for 4 weeks at 40 ° C) that assumed storage for 7 months and a half. I went for both.
  • ⁇ Viscosity> The viscosity of the semi-solidified nutrient was measured using a B-type viscometer DV-II + Pro (manufactured by Brookfield). The measurement was performed for 1 minute under conditions of room temperature (25 ° C.) and a rotation speed of 6 rpm.
  • ⁇ Nutrient when ejected from the container has a smooth cream state
  • ⁇ Slight roughness and partial aggregation are observed in the nutrient when ejected from the container
  • ⁇ Nutrient when ejected from the container Large aggregates and lumps are seen.
  • ⁇ Stickiness> A 50 mL catheter tip syringe filled with a semi-solid nutrient is connected to a tube with an inner diameter of 4 mm, and the entire amount of the semi-solid nutrient is extruded from the syringe. Stickiness was evaluated according to the degree. The stickiness was evaluated according to the following criteria.
  • the semi-solidified nutrients of the examples contain a predetermined amount of at least one selected from the group consisting of pectin, locust bean gum, soybean polysaccharide, and guar gum. It can be seen that the occurrence of water separation is suppressed and the smooth cream-like properties can be maintained.

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Abstract

[Problem] To provide a semi-solidified nutritive agent in which the occurrence of syneresis is minimized. [Solution] A semi-solidified nutritive agent comprising at least: a nutrient including a carbohydrate and a protein source; water; agar; and at least one type of thickener selected from the group consisting of pectin, locust bean gum, soybean polysaccharide, and guar gum; wherein the amount of agar contained is 0.1-0.8 mass% in relation to the total amount of nutritive agent, and the amount of thickener contained is 0.2-1.0 mass% in relation to the total amount of nutritive agent.

Description

半固形化栄養剤Semi-solidified nutrient
　本発明は、半固形化栄養剤に関する。 The present invention relates to a semi-solidified nutrient.
　近年、食物に代替する栄養補給手段として、簡便に所要とする栄養素を摂取できる栄養剤が注目されている。当該栄養剤としては、固形状、半固形状、液状のもの等が知られており、このうち、半固形状の栄養剤は、医療分野、食品分野における栄養補給手段として有用であり、普及が進んでいる。 In recent years, nutritional supplements that can easily consume necessary nutrients have attracted attention as nutritional supplements that replace food. As such nutrients, solid, semi-solid, liquid, etc. are known, and among these, semi-solid nutrients are useful as nutritional supplements in the medical field and food field, and are widely used. Progressing.
　医療分野における上記半固形化栄養剤は、主に、病者、乳児、高齢者等に適用され、投与方法は大きく経口投与、経管投与に分けられる。 The above-mentioned semi-solidified nutrients in the medical field are mainly applied to sick people, infants, elderly people, etc., and the administration method is roughly divided into oral administration and tube administration.
　経口投与は、主に加齢や脳血管障害等により咀嚼や嚥下の動作に困難を伴う嚥下困難者に適用される。嚥下困難者は通常の食事を十分に摂ることが困難である。特に、水や粘性の低い汁物等を摂取する際には、飲み込む力が低下していることから、逆流やむせに対する十分な配慮が必要である。一般的に病院では、市販の増粘剤を液体栄養剤やお茶、水等に混合し、適度な粘性を付与してから投与する等の工夫がなされている。しかしながら、増粘剤を入れすぎてしまうと、部分的に塊になることにより、咽頭残留が生じることがあり、また、増粘剤を食品に添加してから粘度が出る（粘度が安定する）までに若干時間がかかることにより、調製に手間を要することがある等の課題がある。 Oral administration is mainly applied to those who have difficulty swallowing with difficulty in mastication and swallowing due to aging or cerebrovascular disorders. People who have difficulty swallowing have difficulty eating a normal meal. In particular, when ingesting water, low-viscosity juice, or the like, the ability to swallow is reduced, and therefore sufficient consideration must be given to backflow and dusk. Generally, hospitals have devised methods such as mixing commercially available thickeners with liquid nutrients, tea, water, etc., and giving them after giving appropriate viscosity. However, if too much thickener is added, the pharyngeal residue may occur due to partial lumps, and the viscosity increases after the thickener is added to the food (stable viscosity). There is a problem that preparation takes time because it takes a little time to prepare.
　近年、このような嚥下困難者等を対象として、種々の半固形化栄養剤が開発されている。当該半固形化栄養剤に求められる性質としては、適度な粘性、適度な保形性、口腔および咽頭等への付着のしにくさ、離水のしにくさ等が挙げられる。また、栄養状態の改善やＱＯＬ（Ｑｕａｌｉｔｙ　ｏｆ　Ｌｉｆｅ）の向上等の観点から、栄養価が高いことや、食感および風味に優れている等の性質を併せ持つことが望まれている。 In recent years, various semi-solid nutrients have been developed for those with difficulty in swallowing. Properties required for the semi-solidified nutrient include moderate viscosity, moderate shape retention, difficulty in adhering to the oral cavity and pharynx, difficulty in water separation, and the like. Further, from the viewpoints of improving nutritional status and improving QOL (Quality of Life), it is desired to have properties such as high nutritional value and excellent texture and flavor.
　経管投与は、主に経口投与が不可能な高齢者、病者等に対し適用され、経腸栄養法を用いて半固形化栄養剤が投与される。 Tube administration is mainly applied to elderly people and patients who cannot be administered orally, and semi-solid nutrients are administered using enteral nutrition.
　一般的に、経腸栄養法とは、生体が必要とするカロリー、栄養素（タンパク質源やミネラル、ビタミン類等）の需要を満たすことを目的とする栄養法であり、経口摂取に次ぐ生理的なものである。そのため、経口摂取が不可能でも腸が機能している病者に対しては、通常、経静脈的な栄養補給である高カロリー輸液療法（ＴＰＮ）よりも経腸栄養法が選択される。前記経腸栄養法において、栄養剤の投与方法としては、経口胃管を用いた投与、経鼻胃管を用いた投与、胃瘻を用いた投与等が挙げられるが、半固形化栄養剤が用いられる場合には、主として、胃瘻を用いた投与が選択される。この際、求められる性質としては、適度な粘性、胃瘻からチューブを介して投与した際、チューブ内に栄養剤が残りづらい、チューブを汚しづらい等が挙げられる。特に粘性に関しては、高い粘性を維持することが重要である。粘性が低い栄養剤を胃瘻から投与した場合、患者の状態によっては、栄養剤が胃から食道に逆流し、食道炎や肺炎等の問題が発生することがある。 In general, enteral nutrition is a nutritional method aimed at meeting the demand for calories and nutrients (protein sources, minerals, vitamins, etc.) required by the living body, and is the physiological method following oral intake. Is. For this reason, enteral nutrition is usually selected over high calorie infusion therapy (TPN), which is intravenous nutritional supplementation, for patients with intestinal function that cannot be ingested. In the enteral nutrition method, examples of the administration method of the nutrient include administration using an oral gastric tube, administration using a nasogastric tube, administration using a gastrostoma, and the like. When used, administration using gastrostomy is primarily selected. In this case, the required properties include moderate viscosity, and it is difficult for the nutrients to remain in the tube when it is administered from the gastrostomy through the tube, and it is difficult to contaminate the tube. In particular, regarding viscosity, it is important to maintain a high viscosity. When a nutrient with low viscosity is administered from the gastrostomy, depending on the condition of the patient, the nutrient may flow back from the stomach to the esophagus, causing problems such as esophagitis and pneumonia.
　一方、食品分野における上記半固形化栄養剤は、食感が独特であり、簡便かつ迅速に栄養素を摂取できることから、主に、携帯食やダイエット食品等に適用される。この際、近年の健康志向の高まりから、日常必要とされる栄養素だけでなく、身体の生理学的機能や生物学的活動に関与する特定の保健機能成分を含む特定保健用食品、不足しがちな栄養成分をさらに含む栄養機能食品として販売されているものもある。 On the other hand, the above-mentioned semi-solidified nutrient in the food field has a unique texture and can easily and quickly ingest nutrients, so it is mainly applied to portable foods, diet foods and the like. At this time, due to the recent increase in health consciousness, there is a tendency to lack specific health foods that contain specific health functional ingredients that are involved in the physiological functions and biological activities of the body as well as the nutrients that are required on a daily basis. Some are sold as nutritional functional foods that further contain nutritional components.
　上述の半固形化栄養剤としては、これまでに種々のものが報告されている。例えば、特許文献１には、経腸栄養法に適用される半固形化栄養剤として、経腸栄養剤に寒天や全卵を半固形化剤として添加した半固形化栄養剤が開示されている。また、特許文献２には、寒天と、アルギン酸および／またはその塩類を配合することを特徴とするゲル状経腸栄養剤が開示されている。 Various types of semi-solidified nutrients have been reported so far. For example, Patent Document 1 discloses a semi-solid nutrient obtained by adding agar or whole egg as a semi-solid agent to the enteral nutrient as a semi-solid nutrient applied to the enteral nutrition method. . Patent Document 2 discloses a gel enteral nutrient comprising agar and alginic acid and / or a salt thereof.
特許第３５１６６７３号Japanese Patent No. 3516673 特開２００８－６９０９０号公報JP 2008-69090 A
　しかしながら、特許文献１のように、寒天を多く配合して調製された半固形化栄養剤はゼリー状になる傾向があることから、搬送中の輸送や落下の刺激等で一度破砕されると、離水が発生する場合がある。離水が発生した栄養剤を摂取すると、用途に応じて好適に設定された栄養剤の粘度や保形性が変化し、例えば、胃食道逆流や嘔吐、下痢等が生じうる。また、咀嚼、嚥下困難な高齢者や経口摂取不可能な患者等にあっては、離水した水分によって、むせや誤嚥性肺炎等が生じる場合もある。さらに、離水が生じることにより、経時的な安定性や取扱い性の悪化等の問題も生じうる。 However, as in Patent Document 1, since the semi-solidified nutrient prepared by blending a lot of agar tends to be in a jelly shape, once it is crushed by transportation during transportation or stimulation of falling, Water separation may occur. Ingestion of a nutrient that causes water separation changes the viscosity and shape retention of the nutrient that is suitably set according to the application, and may cause gastroesophageal reflux, vomiting, diarrhea, and the like. In addition, in elderly people who are difficult to chew and swallow, patients who cannot be ingested, etc., water that has been removed from the water may cause a rash or aspiration pneumonia. Furthermore, the occurrence of water separation may cause problems such as deterioration over time in stability and handleability.
　また、特許文献２のように、寒天とともにアルギン酸を併用して調製された半固形化栄養剤は、アルギン酸ナトリウム自体がカルシウムイオンと反応して凝集物を形成するため、不均一な半固形化栄養剤となりやすい。 Further, as in Patent Document 2, the semi-solidified nutrient prepared by using alginic acid together with agar has a non-uniform semi-solidified nutrient because sodium alginate itself reacts with calcium ions to form aggregates. It is easy to become an agent.
　そこで、本発明は、離水の発生が抑制された半固形化栄養剤を提供することを目的とする。 Therefore, an object of the present invention is to provide a semi-solidified nutrient in which the occurrence of water separation is suppressed.
　本発明者らは鋭意研究を行った結果、半固形化栄養剤に、所定量の寒天および所定量の増粘剤を含有させることにより、上記課題が解決されうることを見出し、本発明を完成させるに至った。すなわち、本発明は、糖質およびタンパク質源を含む栄養素と、水分と、寒天と、ペクチン、ローカストビーンガム、大豆多糖類、およびグアガムからなる群より選択される少なくとも１種の増粘剤と、を少なくとも含む半固形化栄養剤であって、前記寒天の含有量が栄養剤全量に対して０．１～０．８質量％であり、前記増粘剤の含有量が栄養剤全量に対して０．２～１．０質量％である、半固形化栄養剤である。 As a result of intensive studies, the present inventors have found that the above-mentioned problems can be solved by adding a predetermined amount of agar and a predetermined amount of thickener to the semi-solidified nutrient, and the present invention has been completed. I came to let you. That is, the present invention includes a nutrient containing a carbohydrate and protein source, water, agar, at least one thickener selected from the group consisting of pectin, locust bean gum, soybean polysaccharide, and guar gum, A semi-solidified nutrient containing at least the agar content is 0.1 to 0.8% by mass relative to the total nutrient amount, and the thickener content is relative to the total nutrient amount It is a semi-solidified nutrient that is 0.2 to 1.0% by mass.
　本発明により、離水の発生が抑制された半固形化栄養剤が提供される。 The present invention provides a semi-solidified nutrient in which the occurrence of water separation is suppressed.
　［半固形化栄養剤］
　本発明に係る半固形化栄養剤は、糖質およびタンパク質源を含む栄養素と、水分と、寒天と、ペクチン、ローカストビーンガム、大豆多糖類、およびグアガムからなる群より選択される少なくとも１種の増粘剤と、を少なくとも含む半固形化栄養剤であって、前記寒天の含有量が栄養剤全量に対して０．１～０．８質量％であり、前記増粘剤の含有量が栄養剤全量に対して０．２～１．０質量％である。 [Semi-solidified nutrient]
The semi-solidified nutrient according to the present invention is at least one selected from the group consisting of nutrients including carbohydrates and protein sources, moisture, agar, pectin, locust bean gum, soybean polysaccharide, and guar gum. A semi-solid nutrient containing at least a thickener, wherein the agar content is 0.1 to 0.8% by mass with respect to the total nutrient, and the thickener content is nutrient It is 0.2 to 1.0% by mass based on the total amount of the agent.
　［栄養素］
　栄養素としては、糖質およびタンパク質源を必須に含む。前記栄養素は、任意の成分と
して、さらに脂質、ビタミン、ミネラル、および食物繊維からなる群から選択される少なくとも１種を含んでいてもよい。 [Nutrient]
Nutrients essentially include carbohydrate and protein sources. The nutrient may further contain at least one selected from the group consisting of lipids, vitamins, minerals, and dietary fiber as an optional component.
　半固形化栄養剤中の栄養素の合計量は、１０～５０質量％であることが好ましく、２０～３５質量％であることがより好ましい。 The total amount of nutrients in the semi-solidified nutrient is preferably 10 to 50% by mass, and more preferably 20 to 35% by mass.
　（糖質）
　糖質は、炭水化物とも呼ばれ、エネルギー源となるものである。 (Sugar)
Carbohydrates are also called carbohydrates and serve as energy sources.
　用いられうる糖質としては、生体に吸収されてエネルギー源になるものであれば特に制限はなく、例えば、単糖、二糖、および多糖が挙げられる。単糖の具体例としては、グルコース（ブドウ糖）、フルクトース（果糖）、ガラクトース等が挙げられる。二糖の具体例としては、スクロース（ショ糖）、ラクトース（乳糖）、マルトース（麦芽糖）、イソマルトース、トレハロース等が挙げられる。多糖の具体例としては、デンプン（アミロース、アミロペクチン）、デキストリン等が挙げられる。これらのうち、デキストリンを用いることが好ましい。 The carbohydrate that can be used is not particularly limited as long as it is absorbed into a living body and becomes an energy source, and examples thereof include monosaccharides, disaccharides, and polysaccharides. Specific examples of monosaccharides include glucose (glucose), fructose (fructose), galactose and the like. Specific examples of the disaccharide include sucrose (sucrose), lactose (lactose), maltose (malt sugar), isomaltose, trehalose and the like. Specific examples of the polysaccharide include starch (amylose, amylopectin), dextrin and the like. Of these, dextrin is preferably used.
　デキストリンは、数個のα－グルコースがグリコシド結合によって重合した物質の総称であり、デンプンを加水分解して得ることができる。デキストリンは、小腸内での分解速度が遅く吸収が緩やかであることから、急激な血糖上昇を防止しうる。また、デキストリンを用いることにより、半固形化栄養剤の浸透圧を低減することができ、浸透圧性の下痢を予防しうる。デキストリンとしては、α－グルコースの重合度が高い高分子デキストリン、およびα－グルコースの重合度が低い低分子デキストリンのいずれを用いてもよいが、より浸透圧を低減可能な高分子デキストリンを用いることが好ましい。なお、低分子デキストリンは、マルトデキストリンとも呼ばれ、通常、３～５個のα－グルコースが重合したものである。 Dextrin is a general term for substances in which several α-glucoses are polymerized by glycosidic bonds, and can be obtained by hydrolysis of starch. Since dextrin has a slow degradation rate in the small intestine and is slowly absorbed, it can prevent a rapid increase in blood sugar. Moreover, by using dextrin, the osmotic pressure of the semi-solidified nutrient can be reduced, and osmotic diarrhea can be prevented. As the dextrin, either a high molecular dextrin having a high degree of polymerization of α-glucose or a low molecular dextrin having a low degree of polymerization of α-glucose may be used, but a high molecular dextrin capable of further reducing the osmotic pressure should be used. Is preferred. The low molecular dextrin is also called maltodextrin and is usually a polymer of 3 to 5 α-glucose.
　デキストリンは、自ら調製しても、市販品を用いてもよい。デキストリンを調製する場合には、公知のデンプン、例えば、トウモロコシ、ワキシーコーン、小麦、米、ワキシーライス、ワキシーミロ、豆（ソラマメ、緑豆、小豆等）、馬鈴薯、甘藷、タピオカ等に含有されるデンプンを、公知の方法により加水分解することで調製することができる。一方、市販されたデキストリンとしては、ＴＫ－１６（松谷化学工業株式会社製）等が挙げられ、好適に使用することができる。 Dextrin may be prepared by itself or a commercially available product may be used. When preparing dextrin, known starches such as corn, waxy corn, wheat, rice, waxy rice, waxy miro, beans (broad beans, mung beans, red beans, etc.), potatoes, sweet potatoes, tapioca, etc. It can be prepared by hydrolysis by a known method. On the other hand, examples of commercially available dextrin include TK-16 (manufactured by Matsutani Chemical Industry Co., Ltd.) and the like, which can be preferably used.
　上述の糖質は、単独で用いても、２種以上を混合して用いてもよい。 The above carbohydrates may be used alone or in combination of two or more.
　半固形化栄養剤中の糖質の含有量は、適用する対象者によって適宜調節されうるが、半固形化栄養剤全量に対して５～２５質量％であることが好ましい。 The content of the saccharide in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied, but is preferably 5 to 25% by mass with respect to the total amount of the semi-solidified nutrient.
　（タンパク質源）
　タンパク質源としては、特に制限されず、公知のものが用いられうる。例えば、アミノ酸、ペプチド、植物タンパク質、動物タンパク質等が挙げられる。 (Protein source)
The protein source is not particularly limited, and known proteins can be used. For example, amino acids, peptides, plant proteins, animal proteins and the like can be mentioned.
　アミノ酸としては、バリン、ロイシン、イソロイシン、リシン、メチオニン、フェニルアラニン、トレオニン、トリプトファン、ヒスチジン等の必須アミノ酸；およびグリシン、アラニン、セリン、システイン、アスパラギン、グルタミン、プロリン、チロシン、アスパラギン酸、グルタミン酸、アルギニン等の非必須アミノ酸が挙げられる。これらの他、４－ヒドロキシプロリン、５－ヒドロキシリジン、γ－カルボキシグルタミン酸、Ｏ－ホスホセリン、Ｏ－ホスホチロシン、Ｎ－アセチルセリン、Ｎω－メチルアルギニン、ピログルタミン酸、Ｍ－ホルミルメチオニン等の修飾アミノ酸；オルニチン、シトルリン、γ－アミノ酪酸（ＧＡＢＡ）、チロキシン、Ｓ－アデニルメチオニン等の特殊アミノ酸も包含されうる。また、前記アミノ酸は、それぞれ立体異性体（エナンチオマー、ジアステレオマー）であっても、位置異性体であってもよく、これらの混合物であってもよい。さらに、前記アミノ酸は、無機酸塩（塩酸塩等）、有機酸塩（酢酸塩等）、生体内で加水分解可能なエステル体（メチルエステル等）の形態であってもよい。 Amino acids include essential amino acids such as valine, leucine, isoleucine, lysine, methionine, phenylalanine, threonine, tryptophan, histidine; and glycine, alanine, serine, cysteine, asparagine, glutamine, proline, tyrosine, aspartic acid, glutamic acid, arginine, etc. Of the non-essential amino acids. In addition to these, modified amino acids such as 4-hydroxyproline, 5-hydroxylysine, γ-carboxyglutamic acid, O-phosphoserine, O-phosphotyrosine, N-acetylserine, Nω-methylarginine, pyroglutamic acid, M-formylmethionine; ornithine Special amino acids such as citrulline, γ-aminobutyric acid (GABA), thyroxine, S-adenylmethionine may also be included. The amino acids may be stereoisomers (enantiomers, diastereomers), positional isomers, or a mixture thereof. Furthermore, the amino acid may be in the form of an inorganic acid salt (hydrochloride or the like), an organic acid salt (acetate or the like), or an ester body (methyl ester or the like) that can be hydrolyzed in vivo.
　ペプチドとしては、上記アミノ酸の２以上がペプチド結合（アミド結合）を介して重合したものが用いられうる。当該ペプチドは、ジペプチド、トリペプチド、オリゴペプチド（アミノ酸が約１０個程度のもの）、ポリペプチド（アミノ酸が数十～数百個のもの）のいずれであってもよい。なお、一部のオリゴペプチド、例えば、ラクトトリペプチド、カゼインドデカペプチド、バリルチロシン含有サーデンペプチド等は降圧作用等の保健機能を有しうる。 As the peptide, one obtained by polymerizing two or more of the above amino acids via a peptide bond (amide bond) can be used. The peptide may be a dipeptide, a tripeptide, an oligopeptide (having about 10 amino acids), or a polypeptide (having several tens to several hundred amino acids). Some oligopeptides such as lactotripeptides, casein decapeptides, valyltyrosine-containing sadden peptides and the like may have health functions such as antihypertensive action.
　植物タンパク質としては、米等の穀類、大豆、豆腐等の豆類等に含まれるタンパク質が挙げられる。なお、大豆タンパク質については、胆汁酸と結合してコレステロールの排泄を促進する等の保健機能を有しうる。 Examples of plant proteins include proteins contained in grains such as rice and beans such as soybeans and tofu. In addition, about soy protein, it can have health functions, such as combining with a bile acid and promoting the excretion of cholesterol.
　動物性タンパク質としては、卵、肉類、魚介類、牛乳等に含まれるタンパク質が挙げられる。 Examples of animal proteins include proteins contained in eggs, meat, seafood, milk and the like.
　これらのうち、牛乳（乳清）を原料とするホエイタンパク質、牛乳に含まれるカゼインタンパク質、大豆タンパク質を用いることが好ましく、ホエイタンパク質を用いることがより好ましい。当該ホエイタンパク質としては、ホエイプロテインコンセントレート（ＷＰＣ）、ホエイプロテインアイソレート（ＷＰＩ）、加水分解ホエイペプチド（ＷＰＨ）等が挙げられる。ＷＰＣやＷＰＩ、大豆タンパク等は市販されているものを用いてもよく、市販品としては、ＷＰＩ１８８５５（Ｆｏｎｔｅｒｒａ社製）、ＷＰＩ１８８２２（Ｆｏｎｔｅｒｒａ社製）、ＷＰＩ１８９５（Ｆｏｎｔｅｒｒａ社製）、ＷＰＣ３９２（Ｆｏｎｔｅｒｒａ社製）、ＷＰＣ８０（Ｆｏｎｔｅｒｒａ社製）、ＷＰＣ７００９（Ｆｏｎｔｅｒｒａ社製）、ＷＰＣ１６４（Ｆｏｎｔｅｒｒａ社製）、ＷＰＣ１６２（Ｆｏｎｔｅｒｒａ社製）、ＷＰＣ１３２（Ｆｏｎｔｅｒｒａ社製）、ＷＰＣ４７２（Ｆｏｎｔｅｒｒａ社製）、プロリーナ９００（不二製油株式会社製）、ニューフジプロ３０００（不二製油株式会社製）、ニューフジプロ１７００Ｎ（不二製油株式会社製）等が挙げられる。 Of these, whey protein made from milk (whey) as a raw material, casein protein contained in milk, and soybean protein are preferably used, and whey protein is more preferably used. Examples of the whey protein include whey protein concentrate (WPC), whey protein isolate (WPI), hydrolyzed whey peptide (WPH) and the like. Commercially available products such as WPC, WPI, and soy protein may be used. As commercially available products, WPI18855 (manufactured by Fontera), WPI18822 (manufactured by Fontera), WPI1895 (manufactured by Fontera), WPC392 (manufactured by Fontera) ), WPC80 (manufactured by Fontera), WPC7009 (manufactured by Fontera), WPC164 (manufactured by Fontera), WPC162 (manufactured by Fontera), WPC132 (manufactured by Fontera), WPC472 (manufactured by Fontera), Prolina 900 (Fuji Oil) New Fuji Pro 3000 (Fuji Oil Co., Ltd.), New Fuji Pro 1700N (Fuji Oil Co., Ltd.) and the like.
　上述のタンパク質源は、単独で用いても、２種以上を混合して用いてもよい。 The above protein sources may be used alone or in combination of two or more.
　半固形化栄養剤中のタンパク質源の含有量は、適用する対象者によって適宜調節されうるが、半固形化栄養剤全量に対して１～１８質量％であることが好ましい。 The content of the protein source in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied, but is preferably 1 to 18% by mass with respect to the total amount of the semi-solidified nutrient.
　（脂質）
　脂質は、エネルギー源、生体膜構成成分、ステロイドホルモンや胆汁酸の合成原料となりうる。 (Lipid)
Lipids can be a source of energy, biomembrane constituents, steroid hormones and bile acids.
　用いられうる脂質としては、特に制限されず、飽和脂肪酸、不飽和脂肪酸、植物油、動物性油脂、魚油等が挙げられる。 The lipid that can be used is not particularly limited, and examples thereof include saturated fatty acids, unsaturated fatty acids, vegetable oils, animal fats and oils, and fish oils.
　飽和脂肪酸としては、カプリル酸、カプリン酸、ラウリン酸、パルミチン酸、ステアリン酸等が挙げられる。 Examples of saturated fatty acids include caprylic acid, capric acid, lauric acid, palmitic acid, stearic acid and the like.
　不飽和脂肪酸としては、オレイン酸、パルミトレイン酸、リノール酸、アラキドン酸、α－リノレン酸、エイコサペンタエン酸（ＥＰＡ）、ドコサヘキサエン酸（ＤＨＡ）等が挙げられる。なお、ＥＰＡやＤＨＡについては、血中コレステロール上昇抑制作用、中性脂肪上昇抑制作用等の保健機能を有しうる。 Examples of unsaturated fatty acids include oleic acid, palmitoleic acid, linoleic acid, arachidonic acid, α-linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). In addition, about EPA and DHA, it can have health functions, such as a blood cholesterol raise inhibitory effect and a neutral fat rise inhibitory effect.
　植物油としては、ココナッツオイル、コーン油、綿実油、オリーブオイル、パーム油、パーム核油、ピーナッツ油、菜種油、サフラワー油（紅花油）、ごま油、大豆油、ヒマワリ油、アーモンド油、カシュー油、ヘーゼルナッツ油、マカダミアナッツ油、モンゴンゴ油、ペカン油、松の実油、ピスタチオ油、クルミ油、ヒョウタン実油、バッファローカボチャ油、カボチャ実油、スイカ実油、アマランサスオイル、あんず油、リンゴ油、アルガンオイル、アボカド油、ババスオイル、モリンガ油、ボルネオ脂、ケープ栗油、ココアバター、キャロブオイル、コフネヤシ油、コリアンダー種油、ディカ油、アマニ油、グレープシードオイル、ヘンプオイル、カポック実油、ラッレマンチアオイル、マルーラ油、メドウフォーム油、カラシ油、ナツメグバター、オクラ油、パパイヤ油、シソ油、ペクイ油、松の実油、ケシ油、プルーン油、キヌア油、ニガー種子油、こめ油、Ｒｏｙｌｅ油、サッチャインチオイル、ツバキ油、アザミ油、トマト油、コムギ油、エゴマ油、サンフラワー油、胚芽油、ヤシ油、落花生油等が挙げられる。 Vegetable oils include coconut oil, corn oil, cottonseed oil, olive oil, palm oil, palm kernel oil, peanut oil, rapeseed oil, safflower oil (safflower oil), sesame oil, soybean oil, sunflower oil, almond oil, cashew oil, hazelnut Oil, macadamia nut oil, mongolian oil, pecan oil, pine nut oil, pistachio oil, walnut oil, gourd seed oil, buffalo pumpkin oil, pumpkin seed oil, watermelon seed oil, amaranth oil, apricot oil, apple oil, argan oil , Avocado oil, babas oil, moringa oil, borneo oil, cape chestnut oil, cocoa butter, carob oil, kofne palm oil, coriander seed oil, dica oil, flaxseed oil, grape seed oil, hemp oil, kapok seed oil, lale mantia oil , Marula oil, Meadow foam oil, mustard oil, Tsumug butter, okra oil, papaya oil, perilla oil, pequi oil, pine nut oil, poppy oil, prune oil, quinoa oil, niger seed oil, rice bran oil, Royle oil, Thatcha inch oil, camellia oil, thistle oil, tomato oil , Wheat oil, sesame oil, sunflower oil, germ oil, coconut oil, peanut oil and the like.
　動物性油脂としては、ラード（豚脂）、ヘット（牛脂）、乳脂等が挙げられる。 Animal fats include lard (pig fat), head (tallow), milk fat, and the like.
　魚油としては、サバ、サケ、ブリ、イワシ、サンマ等の魚油が挙げられる。 Fish oil includes fish oil such as mackerel, salmon, yellowtail, sardine, saury.
　これらのうち、ヒトが生体内で合成することができないリノール酸およびα－リノレン酸、またはこれらを含む脂質を用いることが好ましい。 Among these, it is preferable to use linoleic acid and α-linolenic acid that cannot be synthesized in vivo by humans, or lipids containing these.
　上述の脂質は、単独で用いても、２種以上を混合して用いてもよい。 The above-described lipids may be used alone or in combination of two or more.
　半固形化栄養剤中の脂質の含有量は、適用する対象者によって適宜調節されうるが、半固形化栄養剤全量に対して０～１０質量％であることが好ましい。 The lipid content in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied, but is preferably 0 to 10% by mass with respect to the total amount of the semi-solidified nutrient.
　（ビタミン）
　ビタミンとは、生物の栄養状態を保つために必要とする糖質、タンパク質源、脂質以外の有機化合物の総称である。 (vitamin)
Vitamins are a general term for organic compounds other than carbohydrates, protein sources, and lipids that are necessary to maintain the nutritional state of living organisms.
　ビタミンとしては、ビタミンＡ（レチノール）、ビタミンＤ（エルゴカルシフェロール、コレカルシフェロール）、ビタミンＥ（トコフェロール、トコトリエノール）ビタミンＫ（フィロキノン、メナキノン）等の脂溶性ビタミン：ビタミンＢ１（チアミン）、ビタミンＢ２（リボフラビン）、ビタミンＢ３（ナイアシン）、ビタミンＢ５（パントテン酸）、ビタミンＢ６（ピリドキサール、ピリドキサミン、ピリドキシン）、ビタミンＢ７（ビオチン）、ビタミンＢ９（葉酸）、ビタミンＢ１２（シアノコバラミン、ヒドロキソコバラミン）、ビタミンＣ（アスコルビン酸）等の水溶性ビタミンが挙げられる。これらのビタミンは、単独で用いても、２種以上を混合して用いてもよい。 Vitamin A (retinol), vitamin D (ergocalciferol, cholecalciferol), vitamin E (tocopherol, tocotrienol) vitamin K (phylloquinone, menaquinone) and other fat-soluble vitamins: vitamin B1 (thiamine), vitamin B2 (Riboflavin), vitamin B3 (niacin), vitamin B5 (pantothenic acid), vitamin B6 (pyridoxal, pyridoxamine, pyridoxine), vitamin B7 (biotin), vitamin B9 (folic acid), vitamin B12 (cyanocobalamin, hydroxocobalamin), vitamin C And water-soluble vitamins such as (ascorbic acid). These vitamins may be used alone or in combination of two or more.
　半固形化栄養剤中のビタミンの含有量は、適用する対象者等によって適宜調節されうる。通常、脂溶性ビタミンについては過剰症が生じない量で添加され、水溶性ビタミンについては添加量に制限はない。半固形化栄養剤１００ｇあたりの各ビタミンの好ましい含有量は以下の通りである。 The content of vitamins in the semi-solidified nutrient can be adjusted as appropriate by the subject to be applied. Normally, fat-soluble vitamins are added in an amount that does not cause excess disease, and water-soluble vitamins are not limited in the amount added. The preferable content of each vitamin per 100 g of the semi-solidified nutrient is as follows.
　脂溶性ビタミン；
　ビタミンＡ：好ましくは０～３０００μｇ、より好ましくは２０～２００μｇ
　ビタミンＤ：好ましくは０．１～５０μｇ、より好ましくは０．１～５．０μｇ
　ビタミンＥ：好ましくは０．２～８００ｍｇ、より好ましくは１～１０ｍｇ
　ビタミンＫ：好ましくは０．５～１０００μｇ、より好ましくは２～５０μｇ
　水溶性ビタミン；
　ビタミンＢ１：好ましくは０．０１～４０ｍｇ、より好ましくは０．１～５ｍｇ
　ビタミンＢ２：好ましくは０．０１～２０ｍｇ、より好ましくは０．０５～５ｍｇ
　ナイアシン：好ましくは０．１～３００ｍｇＮＥ、より好ましくは０．５～３０ｍｇＮＥ
　パントテン酸：好ましくは０．１～５５ｍｇ、より好ましくは０．２～１０ｍｇ
　ビタミンＢ６：好ましくは０．０１～６０ｍｇ、より好ましくは０．１～１０ｍｇ
　ビオチン：好ましくは０．１～１０００μｇ、より好ましくは１～１００μｇ
　葉酸：好ましくは１～１０００μｇ、より好ましくは１０～２００μｇ
　ビタミンＢ１２：好ましくは０．０１～１００μｇ、より好ましくは０．２～６０μｇ
　ビタミンＣ：好ましくは１～２０００ｍｇ、より好ましくは５～１０００ｍｇ。 Fat-soluble vitamins;
Vitamin A: preferably 0 to 3000 μg, more preferably 20 to 200 μg
Vitamin D: preferably 0.1-50 μg, more preferably 0.1-5.0 μg
Vitamin E: preferably 0.2 to 800 mg, more preferably 1 to 10 mg
Vitamin K: preferably 0.5 to 1000 μg, more preferably 2 to 50 μg
Water-soluble vitamins;
Vitamin B1: preferably 0.01 to 40 mg, more preferably 0.1 to 5 mg
Vitamin B2: preferably 0.01-20 mg, more preferably 0.05-5 mg
Niacin: preferably 0.1 to 300 mg NE, more preferably 0.5 to 30 mg NE
Pantothenic acid: preferably 0.1 to 55 mg, more preferably 0.2 to 10 mg
Vitamin B6: preferably 0.01-60 mg, more preferably 0.1-10 mg
Biotin: preferably 0.1 to 1000 μg, more preferably 1 to 100 μg
Folic acid: preferably 1-1000 μg, more preferably 10-200 μg
Vitamin B12: preferably 0.01-100 μg, more preferably 0.2-60 μg
Vitamin C: preferably 1 to 2000 mg, more preferably 5 to 1000 mg.
　（ミネラル）
　ミネラルとは、生物の栄養状態を保つために必要とする有機化合物以外の元素である。 (mineral)
Minerals are elements other than organic compounds that are necessary for maintaining the nutritional state of living organisms.
　ミネラルとしては、ナトリウム、カリウム、カルシウム、リン、マグネシウム等の準主要元素；鉄、亜鉛、銅、ヨウ素、マンガン、セレン、クロム、モリブデン等の必須微量元素等が挙げられる。これらのミネラルは、単独で用いても、２種以上を混合して用いてもよい。 Minerals include quasi-major elements such as sodium, potassium, calcium, phosphorus and magnesium; essential trace elements such as iron, zinc, copper, iodine, manganese, selenium, chromium and molybdenum. These minerals may be used alone or in combination of two or more.
　半固形化栄養剤中のミネラルの含有量は、適用する対象者等によって適宜調節されうる。半固形化栄養剤１００ｇあたりの各ミネラルの好ましい含有量は以下の通りである。 The content of mineral in the semi-solidified nutrient can be adjusted as appropriate by the subject to be applied. The preferable content of each mineral per 100 g of the semi-solidified nutrient is as follows.
　準主要元素；
　ナトリウム：好ましくは５～６０００ｍｇ、より好ましくは１０～３５００ｍｇ
　カリウム：好ましくは１～３５００ｍｇ、より好ましくは２５～１８００ｍｇ
　カルシウム：好ましくは１０～２３００ｍｇ、より好ましくは３０～３００ｍｇ
　リン：好ましくは１～３５００ｍｇ、より好ましくは２５～１５００ｍｇ
　マグネシウム：好ましくは１～７４０ｍｇ、より好ましくは１０～１５０ｍｇ
　必須微量元素；
　鉄：好ましくは０．１～５５ｍｇ、より好ましくは１～１０ｍｇ
　亜鉛：好ましくは０．１～３０ｍｇ、より好ましくは１～１５ｍｇ
　銅：好ましくは０．０１～１０ｍｇ、より好ましくは０．０６～６ｍｇ
　ヨウ素：好ましくは０．１～３０００μｇ、より好ましくは１～１５０μｇ
　マンガン：好ましくは０．０１～１１ｍｇ、より好ましくは０．１～４ｍｇ
　セレン：好ましくは０．１～４５０μｇ、より好ましくは１～３５μｇ
　クロム：好ましくは０．１～４０μｇ、より好ましくは１～３５μｇ
　モリブデン：好ましくは０．１～３２０μｇ、より好ましくは１～２５μｇ。 Quasi-major elements;
Sodium: preferably 5 to 6000 mg, more preferably 10 to 3500 mg
Potassium: preferably 1 to 3500 mg, more preferably 25 to 1800 mg
Calcium: preferably 10-2300 mg, more preferably 30-300 mg
Phosphorus: preferably 1 to 3500 mg, more preferably 25 to 1500 mg
Magnesium: preferably 1 to 740 mg, more preferably 10 to 150 mg
Essential trace elements;
Iron: preferably 0.1 to 55 mg, more preferably 1 to 10 mg
Zinc: preferably 0.1-30 mg, more preferably 1-15 mg
Copper: preferably 0.01 to 10 mg, more preferably 0.06 to 6 mg
Iodine: preferably 0.1 to 3000 μg, more preferably 1 to 150 μg
Manganese: preferably 0.01 to 11 mg, more preferably 0.1 to 4 mg
Selenium: preferably 0.1 to 450 μg, more preferably 1 to 35 μg
Chromium: preferably 0.1 to 40 μg, more preferably 1 to 35 μg
Molybdenum: preferably 0.1 to 320 μg, more preferably 1 to 25 μg.
　（食物繊維）
　食物繊維は、栄養素利用度の低下、血漿コレステロールの低下、血糖応答の改善、大腸機能の改善、および大腸がんの予防等の機能を有しうる。なお、食物繊維は、腸内細菌により醗酵を受けて短鎖脂肪酸、炭酸ガス、水素ガス、メタンガス等に変換される場合がある。このうち、短鎖脂肪酸については大腸で吸収されるため、食物繊維はエネルギー源となる場合がある。 (Dietary fiber)
Dietary fiber can have functions such as reduced nutrient utilization, reduced plasma cholesterol, improved blood glucose response, improved colon function, and prevention of colon cancer. In addition, dietary fiber may be fermented by intestinal bacteria and converted to short chain fatty acids, carbon dioxide gas, hydrogen gas, methane gas, and the like. Among these, since short chain fatty acids are absorbed in the large intestine, dietary fiber may be an energy source.
　食物繊維としては、特に制限されないが、セルロース、ヘミセルロース、リグニン、不溶性ペクチン、キチン、キトサン、難消化性デキストリン、ポリデキストロース、グアガム分解物、サイリウム種皮、低分子化アルギン酸ナトリウム等の不溶性食物繊維；水溶性ペクチン、グアガム、コンニャクマンナン、グルコマンナン、アルギン酸、寒天、化学修飾多糖類、ポリデキストロース、難消化性オリゴ糖、マルチトール、イヌリン、カラギナン、小麦ふすま、パインファイバーＣ等の水溶性食物繊維等が挙げられる。これらの食物繊維は、単独で用いても、２種以上を混合して用いてもよい。 The dietary fiber is not particularly limited, but insoluble dietary fiber such as cellulose, hemicellulose, lignin, insoluble pectin, chitin, chitosan, indigestible dextrin, polydextrose, guar gum degradation product, psyllium seed coat, low molecular weight sodium alginate; Water-soluble dietary fiber such as sex pectin, guar gum, konjac mannan, glucomannan, alginic acid, agar, chemically modified polysaccharide, polydextrose, indigestible oligosaccharide, maltitol, inulin, carrageenan, wheat bran, pine fiber C, etc. Can be mentioned. These dietary fibers may be used alone or in combination of two or more.
　半固形化栄養剤中の食物繊維の含有量は、適用する対象者等によって適宜調節されうる。 The content of dietary fiber in the semi-solidified nutrient can be adjusted as appropriate by the subject to be applied.
　［水分］
　本発明に係る半固形化栄養剤は水分を含む。 [moisture]
The semi-solidified nutrient according to the present invention contains moisture.
　半固形化栄養剤中の水分の含有量は、適用する対象者や所望とする粘度等によって適宜調節されうるが、半固形化栄養剤全量に対して４０～９０質量％であることが好ましい。 The water content in the semi-solidified nutrient can be adjusted as appropriate depending on the subject to be applied and the desired viscosity, but is preferably 40 to 90% by mass with respect to the total amount of the semi-solidified nutrient.
　［寒天］
　本形態に係る半固形化栄養剤は、半固形化栄養剤全量に対して０．１～０．８質量％、好ましくは０．３～０．６質量％の寒天を含む。半固形化栄養剤が、所定量の増粘剤とともに前記含有量で寒天を含むことにより、保水性が向上し、離水が抑制されうる。 [Agar]
The semi-solidified nutrient according to this embodiment contains 0.1 to 0.8% by mass, preferably 0.3 to 0.6% by mass of agar, based on the total amount of the semi-solidified nutrient. When the semi-solidified nutrient contains agar with the above-mentioned content together with a predetermined amount of thickener, water retention can be improved and water separation can be suppressed.
　寒天とは、テングサ、オゴノリ等の紅藻類の粘液質を凍結・乾燥したものであり、アガロースやアガロペクチン等の多糖類を主成分として含む。前記アガロースやアガロペクチンは、ガラクトースおよび３，６－アンデヒドロガラクトースが交互に重合した構造を有する。寒天は、アガロースやアガロペクチンの重合度や分子量、寒天中の硫酸基およびピルビン酸基の含有量等によって性状が異なる場合があるが、本形態に係る半固形化栄養剤においては、特に制限されず、いずれのものを用いてもよい。なお、弾性が高い寒天を用いると、半固形化栄養剤は固体に近いゼリー状となる傾向にある。一方、弾性が小さい寒天を用いると、半固形化栄養剤は液体に近いペースト状となる傾向にある。市販品としては、例えば、ウルトラ寒天ＵＸ３０（伊那食品工業株式会社製）、ウルトラ寒天ＵＸ１００（伊那食品工業株式会社製）ウルトラ寒天ＡＸ－３０（伊那食品工業株式会社製）、ウルトラ寒天ＡＸ－１００（伊那食品工業株式会社製）、ウルトラ寒天ＢＸ－３０（伊那食品工業株式会社製）、ウルトラ寒天ＢＸ－１００（伊那食品工業株式会社製）等を用いることができる。 Agar is a product obtained by freezing and drying mucus of red algae such as agaric and tiger beetle, and contains polysaccharides such as agarose and agaropectin as a main component. The agarose and agaropectin have a structure in which galactose and 3,6-andehydrogalactose are alternately polymerized. Agar may have different properties depending on the degree of polymerization and molecular weight of agarose and agaropectin, the content of sulfate groups and pyruvate groups in the agar, etc., but it is not particularly limited in the semi-solidified nutrient according to this embodiment. Any of these may be used. In addition, when agar with high elasticity is used, the semi-solidified nutrient tends to be in a jelly shape close to a solid. On the other hand, when agar with low elasticity is used, the semi-solidified nutrient tends to be a paste that is close to a liquid. Examples of commercially available products include Ultra Agar UX30 (manufactured by Ina Food Industry Co., Ltd.), Ultra Agar UX100 (manufactured by Ina Food Industry Co., Ltd.), Ultra Agar AX-30 (manufactured by Ina Food Industry Co., Ltd.), and Ultra Agar AX-100 ( Ina Food Industry Co., Ltd.), Ultra Agar BX-30 (Ina Food Industry Co., Ltd.), Ultra Agar BX-100 (Ina Food Industry Co., Ltd.) and the like can be used.
　［増粘剤］
　本発明に係る半固形化栄養剤は、ペクチン、ローカストビーンガム、大豆多糖類、およびグアガムからなる群より選択される少なくとも１種の増粘剤を含む。 [Thickener]
The semi-solidified nutrient according to the present invention includes at least one thickener selected from the group consisting of pectin, locust bean gum, soybean polysaccharide, and guar gum.
　半固形化栄養剤中のペクチン、ローカストビーンガム、大豆多糖類、およびグアガムからなる群より選択される少なくとも１種の増粘剤の含有量は、半固形化栄養剤全量に対して０．２～１．０質量％である。前記増粘剤の含有量が０．２質量％未満であると、保水性を維持することが困難となり離水が発生する。増粘剤の含有量が１．０質量％を越えると、べたつきが強くなる傾向がある。該含有量は好ましくは０．３～０．６質量％である。 The content of at least one thickener selected from the group consisting of pectin, locust bean gum, soybean polysaccharide, and guar gum in the semi-solidified nutrient is 0.2 with respect to the total amount of the semi-solidified nutrient. It is -1.0 mass%. If the content of the thickener is less than 0.2% by mass, it is difficult to maintain water retention and water separation occurs. When the content of the thickener exceeds 1.0% by mass, stickiness tends to increase. The content is preferably 0.3 to 0.6% by mass.
　本形態に係る半固形化栄養剤は、さらに上記増粘剤以外の増粘剤を含んでいてもよい。 The semi-solidified nutrient according to this embodiment may further contain a thickener other than the above thickener.
　他の増粘剤の例としては、特に制限されないが、ゼラチン、コンニャクマンナン、キサンタンガム、タマリンドガム、カラギナン、プロピレングリコール、カルボキシメチルセルロースジェランガム、ジェランガム、タラガム、タマリンドシードガム、サイリウムシードガム、アラビアガム、カードラン、プルラン、アルギン酸ナトリウム、トラガントガム、カラヤガム、ビーガム等が用いられうる。これらの増粘剤は、単独で用いても、２種以上を混合して用いてもよい。 Examples of other thickeners include, but are not limited to, gelatin, konjac mannan, xanthan gum, tamarind gum, carrageenan, propylene glycol, carboxymethylcellulose gellan gum, gellan gum, tara gum, tamarind seed gum, psyllium seed gum, gum arabic, curd Orchid, pullulan, sodium alginate, tragacanth gum, karaya gum, bee gum and the like can be used. These thickeners may be used alone or in admixture of two or more.
　［その他の成分］
　本形態に係る半固形化栄養剤は、さらにその他の公知の成分、例えば、保健機能成分、食品添加物、増粘剤等を含んでいてもよい。 [Other ingredients]
The semi-solidified nutrient according to this embodiment may further contain other known components such as health functional ingredients, food additives, thickeners and the like.
　（保健機能成分）
　保健機能成分とは、摂取することによって生体に対し一定の機能を発揮する成分である。当該保健機能成分としては、例えば、難消化性オリゴ糖、糖アルコール、クエン酸リンゴ酸カルシウム（ＣＣＭ）およびカゼインホスホペプチド（ＣＰＰ）の他、キトサン、Ｌ－アラビノース、グァバ葉ポリフェノール、小麦アルブミン、豆鼓エキス、ジアシルグリセロール、ジアシルグリセロール植物性ステロール、大豆イソフラボン、乳塩基性タンパク質等が挙げられる。 (Health functional ingredient)
A health function component is a component that exhibits a certain function for a living body when ingested. Examples of the health function component include indigestible oligosaccharide, sugar alcohol, calcium citrate malate (CCM) and casein phosphopeptide (CPP), chitosan, L-arabinose, guava leaf polyphenol, wheat albumin, beans Examples include drum extract, diacylglycerol, diacylglycerol plant sterol, soy isoflavone, and milk basic protein.
　難消化性オリゴ糖
　難消化性オリゴ糖とは、単糖類がグリコシド結合によって結合した化合物のうち、多糖類ほどは分子量が大きくない（３００～３０００程度）糖類である。前記難消化性オリゴ糖はヒトの消化酵素では分解されず、ヒトの消化酵素で分解されるものについては、上述の糖質に包含されうる。難消化性オリゴ糖を摂取することにより、整腸効果が得られうる。 Indigestible oligosaccharides Indigestible oligosaccharides are saccharides that are not as large in molecular weight as polysaccharides (about 300 to 3000) among compounds in which monosaccharides are linked by glycosidic bonds. The indigestible oligosaccharides are not degraded by human digestive enzymes, but those digested by human digestive enzymes can be included in the aforementioned carbohydrates. Ingestion of indigestible oligosaccharides can provide a bowel regulation effect.
　難消化性オリゴ糖としては、特に制限されないが、キシロオリゴ糖、フラクトオリゴ糖、大豆オリゴ糖、イソマルトオリゴ糖、乳果オリゴ糖、ラクチュロース、ガラクトオリゴ糖等が挙げられる。これらの難消化性オリゴ糖は、単独で用いても、２種以上を混合して用いてもよい。 The indigestible oligosaccharide is not particularly limited, and examples thereof include xylooligosaccharide, fructooligosaccharide, soybean oligosaccharide, isomaltooligosaccharide, dairy oligosaccharide, lactulose, and galactooligosaccharide. These indigestible oligosaccharides may be used alone or in combination of two or more.
　半固形化栄養剤中の難消化性オリゴ糖の含有量は、適用する対象者等によって適宜調節されうる。 The content of indigestible oligosaccharides in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied.
　糖アルコール
　糖アルコールとは、アルドースやケトースのカルボニル基が還元されて生成する糖の一種であり、小腸から体内への吸収が悪くカロリーになりにくいものである。糖アルコールは、口内細菌によって酸に代謝されにくく、歯垢の形成を防止しうる。当該糖アルコールは、低カロリー甘味料として用いられうる。 Sugar alcohol Sugar alcohol is a kind of sugar produced by reduction of the carbonyl group of aldose or ketose, and it is not easily absorbed from the small intestine into the body and does not easily become calories. Sugar alcohol is difficult to be metabolized to acid by oral bacteria and can prevent plaque formation. The sugar alcohol can be used as a low calorie sweetener.
　糖アルコールとしては、エリトリトール、マルチトール、パラチノース等が挙げられる。これらの糖アルコールは、単独で用いても、２種以上を混合して用いてもよい。 Examples of sugar alcohols include erythritol, maltitol, palatinose and the like. These sugar alcohols may be used alone or in admixture of two or more.
　半固形化栄養剤中の糖アルコールの含有量は、適用する対象者等によって適宜調節されうる。 The content of sugar alcohol in the semi-solidified nutrient can be adjusted as appropriate by the subject to be applied.
　クエン酸リンゴ酸カルシウム（ＣＣＭ）およびカゼインホスホペプチド（ＣＰＰ）
　ＣＣＭおよびＣＰＰは、カルシウムの吸収を促進し、骨形成を促進しうる。当該ＣＣＭおよびＣＰＰは、単独で用いても、混合して用いてもよい。また、ＣＣＭおよびＣＰＰは、カルシウムと併用することが好ましい。 Calcium citrate malate (CCM) and casein phosphopeptide (CPP)
CCM and CPP can promote calcium absorption and promote bone formation. The CCM and CPP may be used alone or in combination. CCM and CPP are preferably used in combination with calcium.
　半固形化栄養剤中のＣＣＭおよびＣＰＰの含有量は、適用する対象者等によって適宜調節されうる。 The content of CCM and CPP in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied.
　（食品添加物）
　食品添加物は、食品の加工もしくは保存の目的で、食品に添加、混和、湿潤その他の方法によって使用するものである。食品添加物としては、栄養強化の目的以外にも、例えば、グルコン酸亜鉛およびグルコン酸銅、アスコルビン酸２－グルコシド、シクロデキストリン、酸化防止剤、着色料、甘味料、ｐＨ調整剤、酸味剤、乳化剤、香料等が挙げられる。 (Food additive)
The food additive is used for the purpose of processing or storing the food by adding, mixing, moistening or other methods to the food. As food additives, for example, zinc gluconate and copper gluconate, ascorbic acid 2-glucoside, cyclodextrin, antioxidant, colorant, sweetener, pH adjuster, acidulant, An emulsifier, a fragrance | flavor, etc. are mentioned.
　グルコン酸亜鉛およびグルコン酸銅
　グルコン酸亜鉛およびグルコン酸銅は、グルコン酸の重金属イオンとの高いキレート能を利用したグルコン酸塩である。グルコン酸塩の形態とすると吸収されやすくなることから、亜鉛や銅を効果的に吸収することができる。当該グルコン酸亜鉛およびグルコン酸銅は、単独で用いても、混合して用いてもよい。 Zinc gluconate and copper gluconate Zinc gluconate and copper gluconate are gluconates that utilize high chelating ability of gluconate with heavy metal ions. Since it becomes easy to be absorbed when it is made into the form of gluconate, zinc and copper can be absorbed effectively. The zinc gluconate and copper gluconate may be used alone or in combination.
　半固形化栄養剤中のグルコン酸亜鉛およびグルコン酸銅の含有量は、適用する対象者等によって適宜調節されうる。 The content of zinc gluconate and copper gluconate in the semi-solidified nutrient can be adjusted as appropriate by the subject to be applied.
　アスコルビン酸２－グルコシド
　アスコルビン酸２－グルコシドは、ビタミンＣ（アスコルビン酸）の２位の水酸基にグルコースがα－配位で結合した化合物であり、酸素の攻撃を受けないため通常のビタミンＣよりも安定性が高いビタミンＣ誘導体である。アスコルビン酸２－グルコシドによって効率的にビタミンＣを吸収することができる。 Ascorbic acid 2-glucoside Ascorbic acid 2-glucoside is a compound in which glucose is bonded to the hydroxyl group at the 2-position of vitamin C (ascorbic acid) in an α-coordination, and is not subject to oxygen attack. It is a vitamin C derivative with high stability. Vitamin C can be efficiently absorbed by ascorbic acid 2-glucoside.
　半固形化栄養剤中のアスコルビン酸２－グルコシドの含有量は、適用する対象者等によって適宜調節されうる。 The content of ascorbic acid 2-glucoside in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied.
　シクロデキストリン
　シクロデキストリンとは、グルコースがグルコシド結合によって結合し、環状構造をとった環状オリゴ糖である。６個のグルコースからなるものをα－シクロデキストリン、７個のグルコースからなるものをβ－シクロデキストリン、８個のグルコースからなるものをγ－シクロデキストリンという。シクロデキストリンは、アレルギー抑制効果、血糖値上昇抑制効果、乳化作用等の機能を有しうる。当該シクロデキストリンは、単独で用いても、２種以上を混合して用いてもよい。 Cyclodextrin Cyclodextrin is a cyclic oligosaccharide having a cyclic structure in which glucose is bound by a glucoside bond. Those consisting of 6 glucoses are called α-cyclodextrin, those consisting of 7 glucoses are called β-cyclodextrin, and those consisting of 8 glucoses are called γ-cyclodextrin. Cyclodextrins can have functions such as an allergy suppressing effect, a blood sugar level increase suppressing effect, and an emulsifying action. The said cyclodextrin may be used independently or may be used in mixture of 2 or more types.
　半固形化栄養剤中のシクロデキストリンの含有量は、適用する対象者等によって適宜調節されうる。 The content of cyclodextrin in the semi-solidified nutrient can be appropriately adjusted depending on the subject to be applied.
　酸化防止剤
　酸化防止剤は、半固形化栄養剤の酸化による変質を防止する機能を有する。 Antioxidant Antioxidant has the function of preventing alteration of semi-solidified nutrient due to oxidation.
　酸化防止剤としては、特に制限されないが、アスコルビン酸およびそのナトリウム塩、エリソルビン酸およびそのナトリウム塩等が用いられうる。これらの酸化防止剤は、単独で用いても、２種以上を混合して用いてもよい。 The antioxidant is not particularly limited, but ascorbic acid and its sodium salt, erythorbic acid and its sodium salt, and the like can be used. These antioxidants may be used alone or in combination of two or more.
　着色料
　着色料は、半固形化栄養剤を美しくする機能を有する。 Colorant The colorant has a function of beautifying the semi-solidified nutrient.
　着色料としては、特に制限されないが、食用タール色素（食用赤色２号、３号、４０号、１０２号、１０４号、１０５号、および１０６号、食用青色１号および２号、食用黄色４号および５号、食用緑色３号等）、β－カロテン、水溶性アナトー、クロロフィル誘導体（クロロフィルａ、クロルフィルｂ、銅クロロフィル、銅クロロフィリンナトリウム、鉄クロロフィリンナトリウム等）、リボフラビン、三二酸化鉄、二酸化チタン、ベニバナ黄色素、コチニール色素、クチナシ黄色素、ウコン色素、赤キャベツ色素、ビートレッド、ブドウ果皮色素、パプリカ色素、カラメル等が用いられうる。これらの着色料は、単独で用いても、２種以上を混合して用いてもよい。 Although it does not restrict | limit especially as a coloring agent, Edible tar pigment | dye (Edible red No. 2, No. 3, No. 40, No. 102, No. 104, No. 105, and No. 106, Edible blue No. 1 and No. 2, Edible yellow No. 4 And No. 5, Edible Green No. 3, etc.), β-carotene, water-soluble anato, chlorophyll derivatives (chlorophyll a, chlorphyll b, copper chlorophyll, copper chlorophyllin sodium, iron chlorophyllin sodium, etc.), riboflavin, iron sesquioxide, titanium dioxide Safflower yellow pigment, cochineal pigment, gardenia yellow pigment, turmeric pigment, red cabbage pigment, beet red, grape skin pigment, paprika pigment, caramel and the like can be used. These colorants may be used alone or in admixture of two or more.
　甘味料
　甘味料は、半固形化栄養剤に甘味を付与する機能を有する。 Sweetener The sweetener has a function of imparting sweetness to the semi-solidified nutrient.
　甘味料としては、特に制限されないが、サッカリンおよびそのナトリウム塩、キシリトール、アスパルテーム、スクラロース、アセスルファムカリウム、ズルチン、チクロ（サイクラミン酸）、ネオテーム、トレハロース、エリスリトール、マルチトース、パラ地ノース、ソルビトール、甘草抽出物、ステビア加工の甘味料、ソーマチン、クルクリン、グリチルリチン酸二ナトリウム等が用いられうる。これらの甘味料は、単独で用いても、２種以上を混合して用いてもよい。 The sweetener is not particularly limited, but saccharin and its sodium salt, xylitol, aspartame, sucralose, acesulfame potassium, dulcin, cyclamate, neotame, trehalose, erythritol, maltose, para-north, sorbitol, licorice extract Stevia processed sweeteners, thaumatin, curculin, disodium glycyrrhizinate and the like can be used. These sweeteners may be used alone or in combination of two or more.
　ｐＨ調整剤
　ｐＨ調整剤は、半固形化栄養剤のｐＨを調整する機能を有する。 pH adjuster The pH adjuster has a function of adjusting the pH of the semi-solidified nutrient.
　ｐＨ調整剤としては、特に制限されないが、クエン酸、グルコン酸、コハク酸、炭酸カリウム、炭酸水素ナトリウム、二酸化炭素、乳酸、乳酸ナトリウム、クエン酸ナトリウム、アジピン酸等が用いられうる。これらのｐＨ調整剤は単独で用いても、２種以上を混合して用いてもよい。 The pH adjuster is not particularly limited, and citric acid, gluconic acid, succinic acid, potassium carbonate, sodium hydrogen carbonate, carbon dioxide, lactic acid, sodium lactate, sodium citrate, adipic acid and the like can be used. These pH adjusters may be used alone or in combination of two or more.
　酸味料
　酸味料は、栄養剤への酸味の付与、食品の酸化の防止、およびｐＨの調整等の機能を有する。 Acidulant The acidulant has functions such as imparting acidity to the nutrient, preventing oxidation of the food, and adjusting the pH.
　酸味料としては、特に制限されないが、酢酸、クエン酸、コハク酸、乳酸、リンゴ酸、酒石酸、グルコン酸、リン酸等が用いられうる。これらの酸味料は単独で用いても、２種以上を混合して用いてもよい。 The acidulant is not particularly limited, but acetic acid, citric acid, succinic acid, lactic acid, malic acid, tartaric acid, gluconic acid, phosphoric acid and the like can be used. These acidulants may be used alone or in combination of two or more.
　乳化剤
　乳化剤は、脂質等の油溶性成分の水への溶解性の向上等の機能を有する。 Emulsifier The emulsifier has functions such as improving the solubility of oil-soluble components such as lipids in water.
　乳化剤としては、特に制限されないが、レシチン、サポニン、カゼインナトリウム等の天然乳化剤；グリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、プロピレングリコール脂肪酸エステル、ショ糖脂肪酸エステル等の合成乳化剤等が挙げられる。これらの乳化剤は、単独で用いても、２種以上を混合して用いてもよい。 The emulsifier is not particularly limited, and examples include natural emulsifiers such as lecithin, saponin, and casein sodium; and synthetic emulsifiers such as glycerin fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, and sucrose fatty acid ester. These emulsifiers may be used alone or in combination of two or more.
　香料
　香料は、半固形化栄養剤を着香・嬌臭する機能を有する。 Fragrance The fragrance has a function of flavoring and smelling the semi-solidified nutrient.
　香料としては、特に制限されないが、アセトフェノン、α－アミルシンナムアルデヒド、アニスアルデヒド、ベンズアルデヒド、酢酸ベンジル、ベンジルアルコール、シンナムアルデヒド、ケイ皮酸、シトラール、シトロネラール、シトロネロール、デカナール、デカノール、アセト酢酸エチル、ケイ皮酸エチル、デカン酸エチル、エチルバニリン、オイゲノール、ゲラニオール、酢酸イソアミル、酪酸イソアミル、フェニル酢酸イソアミル、ｄｌ－メントール、ｌ－メントール、サリチル酸メチル、ピペロナール、プロピオン酸、テルピネオール、バニリン、ｄ－ボルネオール等が挙げられる。これらの香料は、単独で用いても、２種以上を混合して用いてもよい。 The fragrance is not particularly limited, but acetophenone, α-amylcinnamaldehyde, anisaldehyde, benzaldehyde, benzyl acetate, benzyl alcohol, cinnamaldehyde, cinnamic acid, citral, citronellal, citronellol, decanal, decanol, ethyl acetoacetate, Ethyl cinnamate, ethyl decanoate, ethyl vanillin, eugenol, geraniol, isoamyl acetate, isoamyl butyrate, isoamyl phenyl acetate, dl-menthol, l-menthol, methyl salicylate, piperonal, propionic acid, terpineol, vanillin, d-borneol, etc. Can be mentioned. These fragrances may be used alone or in combination of two or more.
　その他
　α－アミラーゼ、β－アミラーゼ、グルコアミラーゼ、グルコースイソメラーゼ、トレハロース生成酵素、トレハロース遊離酵素、グルタミナーゼ等の酵素や酵母等が用いられうる。 Other enzymes such as α-amylase, β-amylase, glucoamylase, glucose isomerase, trehalose producing enzyme, trehalose releasing enzyme, glutaminase, yeast and the like can be used.
　半固形化栄養剤中の上記食品添加物の含有量は、適応する対象者等によって適宜調節されうる。 The content of the above-mentioned food additive in the semi-solidified nutrient can be adjusted as appropriate by the target person to be applied.
　本形態に係る半固形化栄養剤は、所定量のペクチン、ローカストビーンガム、大豆多糖類、およびグアガムからなる群より選択される少なくとも１種の増粘剤を含むことで離水の発生を抑制することができる。当該半固形化栄養剤の離水率は１％以下であることが好ましく、０．５％以下であることがより好ましい。離水率が１％以下であると、用途に応じて好適に設定された半固形化栄養剤の粘度や保形性が維持されうることから好ましい。なお、本明細書において、「離水率」は、実施例に記載された方法により測定された値を採用するものとする。 The semi-solidified nutrient according to this embodiment suppresses generation of water separation by containing at least one thickener selected from the group consisting of a predetermined amount of pectin, locust bean gum, soybean polysaccharide, and guar gum. be able to. The water separation rate of the semi-solidified nutrient is preferably 1% or less, and more preferably 0.5% or less. A water separation rate of 1% or less is preferable because the viscosity and shape retention of a semi-solidified nutrient that is suitably set according to the application can be maintained. In addition, in this specification, the value measured by the method described in the Example shall be employ | adopted for "water separation rate".
　また、本形態に係る半固形化栄養剤の粘度は、２５℃において、１０，０００～５０，０００ｍＰａ・ｓであることが好ましく、１５，０００～３０，０００ｍＰａ・ｓであることがより好ましい。半固形化栄養剤の粘度が１０，０００ｍＰａ・ｓ以上であると、胃食道逆流や誤嚥性肺炎等が生じにくくなりうることから好ましい。一方、半固形化栄養剤の粘度が５００００ｍＰａ・ｓ以下であると、消化が容易となりうることから好ましい。当該粘度は、主として、半固形化栄養剤中のペクチン、ローカストビーンガム、大豆多糖類、およびグアガムからなる群より選択される少なくとも１種の増粘剤の含有量により調節することができる。なお、本明細書において、「粘度」は、実施例に記載された方法で測定された値を採用するものとする。 The viscosity of the semi-solidified nutrient according to this embodiment is preferably 10,000 to 50,000 mPa · s, more preferably 15,000 to 30,000 mPa · s at 25 ° C. It is preferable that the semi-solidified nutrient has a viscosity of 10,000 mPa · s or more because gastroesophageal reflux, aspiration pneumonia, and the like can be less likely to occur. On the other hand, it is preferable that the viscosity of the semi-solidified nutrient is 50000 mPa · s or less because digestion can be facilitated. The viscosity can be adjusted mainly by the content of at least one thickener selected from the group consisting of pectin, locust bean gum, soybean polysaccharide, and guar gum in the semi-solidified nutrient. In this specification, “viscosity” is a value measured by the method described in the examples.
　本形態に係る半固形化栄養剤の熱量は、半固形化栄養剤の用途によっても異なるが、０．５～２．５ｋｃａｌ／ｇであることが好ましく、水分管理の安全性の観点からは０．５～１．０ｋｃａｌ／ｇであることがより好ましいが、水分制限のある患者や熱傷の患者等への投与する場合には、１．０～２．５ｋｃａｌ／ｇであることがより好ましい。当該熱量は、糖質、脂質、アミノ酸またはペプチド、および食物繊維等の添加量を適宜設定することで調節することができる。なお、本明細書において、「熱量」とは、実施例に記載された方法で算出された値を採用するものとする。 The calorific value of the semi-solidified nutrient according to this embodiment varies depending on the use of the semi-solidified nutrient, but is preferably 0.5 to 2.5 kcal / g, and is 0 from the viewpoint of water management safety. More preferably, it is 0.5 to 1.0 kcal / g, but more preferably 1.0 to 2.5 kcal / g when it is administered to a patient with water limitation or a burn patient. The calorie | heat amount can be adjusted by setting suitably addition amount, such as saccharide | sugar, a lipid, an amino acid or peptide, and a dietary fiber. In the present specification, the value calculated by the method described in the examples is adopted as the “heat amount”.
　本形態に係る半固形化栄養剤のｐＨは、３．０～４．５であることが好ましく、３．５～３．９であることがより好ましい。ｐＨが上記範囲にあれば、細菌の増殖を抑制することができ、清涼感が得られうることから好ましい。当該ｐＨは、ｐＨ調整剤や酸味料等の添加量を適宜設定することで調節することができる。なお、本明細書において、「ｐＨ」は、実施例に記載された方法で測定された値を採用するものとする。 The pH of the semi-solidified nutrient according to this embodiment is preferably 3.0 to 4.5, and more preferably 3.5 to 3.9. If pH is in the said range, since the proliferation of bacteria can be suppressed and a refreshing feeling can be obtained, it is preferable. The said pH can be adjusted by setting suitably addition amount, such as a pH adjuster and a sour agent. In the present specification, “pH” is a value measured by the method described in the examples.
　［用途］
　上述の半固形化栄養剤は、医療および食品等の分野に適用されうる。 [Usage]
The semi-solidified nutrient described above can be applied to fields such as medicine and food.
　（医療分野）
　医療分野において、半固形化栄養剤は、例えば、経腸栄養剤として用いられ、経腸栄養法に適用されうる。経腸栄養法における半固形化栄養剤の投与方法は、特に制限されないが、通常、経口投与または胃瘻を用いた投与である。経口投与は、咀嚼、嚥下困難であって、腸が機能している高齢者や病者等が対象となりうる。また、胃瘻を用いた投与は、経口摂取困難であって、腸が機能している高齢者や病者等が対象となりうる。 (Medical field)
In the medical field, semi-solidified nutrients are used, for example, as enteral nutrients and can be applied to enteral nutrition. The administration method of the semi-solidified nutrient in enteral nutrition is not particularly limited, but is usually oral administration or administration using gastrostomy. Oral administration can be applied to elderly people and patients who have difficulty in chewing and swallowing and whose intestines are functioning. In addition, administration using a gastrostoma can be targeted to elderly people or patients who have difficulty in oral intake and have a functioning intestine.
　本形態に係る半固形化栄養剤は、栄養素、水分、ならびに所定量のペクチン、ローカストビーンガム、大豆多糖類、およびグアガムからなる群より選択される少なくとも１種の増粘剤を含む。前記栄養素の含有量は、経腸栄養法が目的とする生体が必要とするカロリー、窒素源等の需要を満たすことができる量で含有されることが好ましい。また、半固形化栄養剤の水分量は、投与する高齢者や患者の状態や水分管理等を考慮して設定することが好ましい。 The semi-solidified nutrient according to this embodiment includes nutrients, moisture, and at least one thickener selected from the group consisting of a predetermined amount of pectin, locust bean gum, soybean polysaccharide, and guar gum. It is preferable that the content of the nutrient is contained in an amount capable of satisfying demands such as calories and nitrogen sources required by the living body intended for enteral nutrition. Moreover, it is preferable to set the water content of the semi-solidified nutrient in consideration of the conditions of elderly people and patients to be administered, water management, and the like.
　本形態に係る半固形化栄養剤に必須の成分以外に添加されうる成分については、特に制限されず、投与方法、半固形化栄養剤を適用する高齢者や患者の状態等に応じて適宜設定されうる。例えば、経口投与の場合には摂取時の味の向上、胃瘻を用いた投与の場合にはゲップ時の不快感の防止の観点から、甘味料、酸味料、香料等を添加することが好ましい。また、全身管理を要する患者には、栄養状態を保つために必要とするビタミンやミネラルを含有することが好ましい。消化機能が低下している高齢者等には、半固形化栄養剤の投与による便秘を改善するために、食物繊維を添加することが好ましい。 The components that can be added in addition to the components essential to the semi-solidified nutrient according to the present embodiment are not particularly limited, and are appropriately set according to the administration method, the state of the elderly or patient to which the semi-solidified nutrient is applied Can be done. For example, in the case of oral administration, it is preferable to add sweeteners, acidulants, fragrances and the like from the viewpoint of improving the taste at the time of ingestion, and in the case of administration using a gastrostoma, from the viewpoint of preventing discomfort at the time of getp. . Moreover, it is preferable that the patient who needs whole body management contains the vitamin and mineral required in order to maintain a nutritional state. In order to improve constipation due to the administration of a semi-solidified nutrient, it is preferable to add dietary fiber to elderly people with reduced digestive function.
　本形態に係る半固形化栄養剤によれば、離水の発生が抑制されるから、半固形化栄養剤が所望の動態で吸収され、さらに、胃食道逆流や誤嚥性肺炎を起こしにくくなりうる。また、保存性や、胃瘻を用いた投与における胃瘻チューブの注入時の取り扱い性等も向上しうる。 According to the semi-solidified nutrient according to this embodiment, since the occurrence of water separation is suppressed, the semi-solidified nutrient is absorbed with a desired kinetics, and it may be difficult to cause gastroesophageal reflux and aspiration pneumonia. . In addition, preservability and handling at the time of injection of a gastrostomy tube in administration using a gastrostoma can be improved.
　また、本形態に係る半固形化栄養剤は、離水の発生を抑止しつつ、粘度、熱量、ｐＨ等を調整することができることから、例えば、粘度を調節することによって、胃瘻を用いた投与における胃瘻チューブへの付着性や半固形化栄養剤の消化性が改善されうる。また、熱量を調節することによって、半固形化栄養剤が適用される高齢者や患者の栄養管理が容易となりうる。さらに、ｐＨを調節することによって、保存性や清涼感が向上しうる。当該粘度、熱量、ｐＨ等は、半固形化栄養剤中の成分、およびその含有量を適宜調節することで制御することができる。なお、半固形化栄養剤にどのような成分がどのような量で含有されても、所定量の増粘剤を含むことで、離水の発生が抑制されうる。 Moreover, since the semi-solidified nutrient according to the present embodiment can adjust the viscosity, calorie, pH and the like while suppressing the occurrence of water separation, for example, administration using a gastrostoma by adjusting the viscosity Can improve the adhesion to the gastrostomy tube and the digestibility of the semi-solidified nutrient. In addition, by adjusting the amount of heat, nutrition management of elderly people and patients to which the semi-solidified nutrient is applied can be facilitated. Furthermore, preservability and a refreshing feeling can be improved by adjusting pH. The viscosity, heat amount, pH and the like can be controlled by appropriately adjusting the components in the semi-solidified nutrient and the content thereof. In addition, even if what kind of component is contained in what quantity in a semi-solidification nutrient, generation | occurrence | production of water separation can be suppressed by including a predetermined amount of thickener.
　（食品分野）
　食品分野において、半固形化栄養剤は、例えば、嗜好食品に適用されうる。 (Food field)
In the food field, the semi-solidified nutrient can be applied to a favorite food, for example.
　本形態に係る半固形化栄養剤は、栄養素、水分、および所定量の増粘剤を含む。前記栄養素の含有量は、対象とする消費者に応じて適宜選択することが好ましい。すなわち、ダイエット食品とする場合には栄養素の含有量は低く設定し、食事の代替となる栄養調整食品とする場合には栄養素の含有量は高く設定されうる。また、半固形化栄養剤の水分含有量は、製造しようとする食品の食感やのどこし等を考慮して適宜選択されうる。 The semi-solidified nutrient according to this embodiment includes nutrients, moisture, and a predetermined amount of thickener. The content of the nutrient is preferably selected as appropriate according to the intended consumer. That is, when it is set as a diet food, the content of nutrients can be set low, and when it is set as a nutritionally adjusted food that replaces meals, the content of nutrients can be set high. In addition, the water content of the semi-solidified nutrient can be selected as appropriate in consideration of the texture and whereabouts of the food to be produced.
　本発明に係る半固形化栄養剤に必須の成分以外に添加されうる成分については、特に制限されず、製造しようとする食品に応じて適宜選択されうる。例えば、半固形栄養食品に清涼感を付与する場合には、ｐＨ調整剤を添加してｐＨを酸性にすることが好ましい。また、特定保健用食品として承認を得ようとする場合には、例えば、上述の食物繊維、難消化性オリゴ糖、糖アルコール、クエン酸リンゴ酸カルシウム（ＣＣＭ）およびカゼインホスホペプチド（ＣＰＰ）等のうち所定のもの（保健機能成分）を含有させる必要がある。さらに、栄養機能食品の表示をしようとする場合には、例えば、上述のビタミン、ミネラル等のうち所定もの（栄養成分）を規格基準の範囲内で含有させる必要がある。 The components that can be added in addition to the components essential to the semi-solidified nutrient according to the present invention are not particularly limited, and can be appropriately selected according to the food to be manufactured. For example, when imparting a refreshing feeling to a semi-solid nutritional food, it is preferable to add a pH adjuster to make the pH acidic. In addition, when obtaining approval as a food for specified health use, for example, the above-mentioned dietary fiber, indigestible oligosaccharide, sugar alcohol, calcium citrate malate (CCM), casein phosphopeptide (CPP), etc. Of these, it is necessary to contain the prescribed items (health functional ingredients). Furthermore, when trying to display a nutritional functional food, for example, it is necessary to include predetermined ones (nutrients) of the above-mentioned vitamins and minerals within the range of the standard.
　本形態に係る半固形化栄養剤によれば、離水の発生が抑制されうることから、好適にエネルギー等を補給することができ、また、嗜好性に優れる食品となりうる。 According to the semi-solidified nutrient according to this embodiment, since the occurrence of water separation can be suppressed, energy and the like can be suitably supplied, and the food can be excellent in palatability.
　また、本形態に係る半固形化栄養剤は、離水の発生を抑止しつつ、粘度、熱量、ｐＨ等を調整することができることから、目的に応じて種々の製品開発を行うことができる。例えば、粘度を調節することによって、異なる食感を有する半固形化栄養剤を製造することができる。また、熱量を調節することによって、要望に応じた半固形化栄養剤を製造することができる。さらに、ｐＨを調節することによって、所望の清涼感を付与した半固形化栄養食品を製造することができる。当該粘度、熱量、ｐＨ等は、半固形化栄養剤中の成分、およびその含有量を適宜調節することで制御することができる。なお、半固形化栄養剤にどのような成分がどのような量で含有されても、所定量の増粘剤を含むことで、離水の発生が抑制されうる。 Moreover, since the semi-solidified nutrient according to the present embodiment can adjust the viscosity, calorie, pH and the like while suppressing the occurrence of water separation, various product development can be performed according to the purpose. For example, by adjusting the viscosity, a semi-solidified nutrient having a different texture can be produced. Moreover, the semi-solidification nutrient according to a request can be manufactured by adjusting calorie | heat amount. Furthermore, by adjusting the pH, it is possible to produce a semi-solidified nutritional food imparted with a desired refreshing feeling. The viscosity, heat amount, pH and the like can be controlled by appropriately adjusting the components in the semi-solidified nutrient and the content thereof. In addition, even if what kind of component is contained in what quantity in a semi-solidification nutrient, generation | occurrence | production of water separation can be suppressed by including a predetermined amount of thickener.
　［半固形化栄養剤の製造方法］
　本形態に係る半固形化栄養剤は、公知の方法によって製造することができる。例えば、加温した水に栄養素、寒天、増粘剤、およびその他所望とする成分を添加し、撹拌することにより製造することができる。また、加温した水に寒天を溶解した溶液と、加温した水に増粘剤を溶解した溶液とを準備し、栄養素およびその他所望とする成分をいずれかに添加して、２つの溶液を混合、撹拌することで製造することができる。 [Method for producing semi-solidified nutrient]
The semi-solidified nutrient according to this embodiment can be produced by a known method. For example, it can be produced by adding nutrients, agar, thickener and other desired components to warm water and stirring. Also, prepare a solution in which agar is dissolved in warm water and a solution in which a thickener is dissolved in warm water, add nutrients and other desired ingredients to any of the two solutions, It can be produced by mixing and stirring.
　得られた半固形化栄養剤は、例えば、連続殺菌した後に容器に充填して、製品化することができる。当該連続殺菌の方法としては、特に制限されないが、超高温短時間（ＵＨＴ）殺菌、熱水殺菌、バッチ式殺菌、およびこれらの組み合わせが挙げられる。前記殺菌は、短時間で行うことが好ましい。短時間で殺菌を行うことにより、半固形化栄養剤に含まれる成分の劣化を抑制することができる。 The obtained semi-solidified nutrient can be commercialized by, for example, filling a container after continuous sterilization. Although it does not restrict | limit especially as the method of the said continuous sterilization, Ultra high temperature short time (UHT) sterilization, hot water sterilization, batch type sterilization, and these combination are mentioned. The sterilization is preferably performed in a short time. By performing sterilization in a short time, deterioration of components contained in the semi-solidified nutrient can be suppressed.
　半固形化栄養剤を充填する容器としては、特に限定されず、公知の容器が用いられうる。当該容器としては、テトラパック、カート缶、ガラス容器、金属缶、アルミパウチ、プラスチック容器等が挙げられる。これらのうち、プラスチック容器を用いることが好ましい。 The container for filling the semi-solidified nutrient is not particularly limited, and a known container can be used. Examples of the container include a tetrapack, a cart can, a glass container, a metal can, an aluminum pouch, and a plastic container. Of these, it is preferable to use a plastic container.
　前記プラスチック容器の原料としては、ポリエチレン（ＰＥ）、ポリプロピレン（ＰＰ）、ポリ塩化ビニル（ＰＶＣ）、ポリ酢酸ビニル（ＰＶＡｃ）、ポリカーボネート（ＰＣ）、ポリブチレンテレフタレート(ＰＢＴ)、ポリエチレンテレフタレート(ＰＥＴ）、ポリエチレンナフタレート（ＰＥＮ）、エチレン－酢酸ビニル共重合体（ＥＶＡ）、エチレン－α－オレフィン共重合体、ポリフルオロカーボン、ポリイミド等を用いることが好ましい。 As a raw material of the plastic container, polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), polyvinyl acetate (PVAc), polycarbonate (PC), polybutylene terephthalate (PBT), polyethylene terephthalate (PET), Polyethylene naphthalate (PEN), ethylene-vinyl acetate copolymer (EVA), ethylene-α-olefin copolymer, polyfluorocarbon, polyimide and the like are preferably used.
　前記プラスチック容器には、さらにポリエチレンテレフタレート（ＰＥＴ）、ポリエチレンナフタレート（ＰＥＮ）、エチレン－ビニルアルコール共重合体（ＥＶＯＨ）、ポリ塩化ビニリデン（ＰＶＤＣ）、ポリアクリロニトリル、ポリビニルアルコール、ポリアミド、ポリエステル等を含むガスバリア性樹脂層；アルミ箔、アルミ蒸着フィルム、酸化ケイ素皮膜、酸化アルミ被膜等のガスバリア性無機層を適宜組み合わせて用いてもよい。当該ガスバリア層を設けることによって、酸素や水蒸気等による半固形化栄養剤の劣化を防止しうる。 The plastic container further includes polyethylene terephthalate (PET), polyethylene naphthalate (PEN), ethylene-vinyl alcohol copolymer (EVOH), polyvinylidene chloride (PVDC), polyacrylonitrile, polyvinyl alcohol, polyamide, polyester, and the like. Gas barrier resin layer: Gas barrier inorganic layers such as an aluminum foil, an aluminum vapor deposition film, a silicon oxide film, and an aluminum oxide film may be used in appropriate combination. By providing the gas barrier layer, deterioration of the semi-solidified nutrient due to oxygen, water vapor, or the like can be prevented.
　また、前記容器はさらに遮光されていてもよい。当該遮光によって、例えば、半固形化栄養剤に含有されうるビタミンＡ、ビタミンＢ２、ビタミンＣ、ビタミンＫ等の光による劣化が抑制されうる。 Further, the container may be further shielded from light. By the light shielding, for example, deterioration due to light such as vitamin A, vitamin B2, vitamin C, and vitamin K that can be contained in the semi-solidified nutrient can be suppressed.
　上述の容器は市販されているものを用いてもよく、例えば、ソフトパウチ（株式会社フジシール製）、ボトルドパウチ（凸版印刷株式会社製）、スパウチ（大日本印刷株式会社製）、チアーパック（株式会社細川洋行製）等が用いられうる。 The above-mentioned container may use what is marketed, for example, a soft pouch (made by Fuji Seal Co., Ltd.), a bottled pouch (made by Toppan Printing Co., Ltd.), a spouch (made by Dai Nippon Printing Co., Ltd.), a cheer pack (Co., Ltd.) Hosokawa Yoko) etc. can be used.
　以下、実施例を挙げて本発明を具体的に説明するが、本発明はこれらに限定されるものではない。なお、実施例において「部」または「％」の表示を用いるが、特に断りがない限り「質量部」または「質量％」を表す。 Hereinafter, the present invention will be specifically described with reference to examples, but the present invention is not limited thereto. In addition, although the display of "part" or "%" is used in an Example, unless otherwise indicated, "mass part" or "mass%" is represented.
　（実施例１）
　５Ｌのステンレスバケツに調合水１２００部を投入し、湯浴で８０℃以上まで加温した。次いで、寒天であるウルトラ寒天ＵＸ１００（伊那食品工業株式会社製）１５部、ペクチン　２部、ローカストビーンガム　６部、大豆多糖類　２．５部、およびグアガム　１部を添加、溶解させた。得られた溶液を５０～６０℃まで冷却し、タンパク質源であるＷＰＣ３９２（ホエイプロテインコンセントレート：Ｆｏｎｔｅｒｒａ社製）１５０部、および糖質であるＴＫ－１６（デキストリン：松谷化学工業株式会社製）４００部を添加した。当該溶液に、脂質である植物油６０部、乳化剤であるグリセリン脂肪酸エステル１０部を混合した。さらに、ビタミンとして、水溶性ビタミンミックス０．３部、脂溶性ビタミンミックス１．５部；ミネラルとして、グルコン酸カルシウム２０部、塩化マグネシウム１０部、塩化カリウム３．２部、塩化ナトリウム０．２部、リン酸二水素ナトリウム１０部、およびクエン酸三カリウム６部；食物繊維として、グアガム加水分解物３０部；酵母ミックス０．５部；酸味料としてクエン酸１８部、リンゴ酸８部、および乳酸２７．５部；アスコルビン酸二グルコシド０．６部；グルコン酸亜鉛０．３０部；グルコン酸銅０．０３部；香料１．５部を適宜添加して撹拌した。得られた混合液が４０００部となるまで水を添加し、均一な状態となるまで溶解分散させた。 (Example 1)
1200 parts of the prepared water was put in a 5 L stainless steel bucket and heated to 80 ° C. or higher in a hot water bath. Next, 15 parts of Ultra Agar UX100 (manufactured by Ina Food Industry Co., Ltd.), 2 parts of pectin, 6 parts of locust bean gum, 2.5 parts of soybean polysaccharide, and 1 part of guar gum were added and dissolved. The obtained solution was cooled to 50 to 60 ° C., 150 parts of WPC392 (whey protein concentrate: manufactured by Fonterra) as a protein source, and TK-16 (dextrin: manufactured by Matsutani Chemical Co., Ltd.) as a carbohydrate 400 Parts were added. To this solution, 60 parts of vegetable oil as a lipid and 10 parts of glycerin fatty acid ester as an emulsifier were mixed. Furthermore, as vitamins, water-soluble vitamin mix 0.3 parts, fat-soluble vitamin mix 1.5 parts; minerals as calcium gluconate 20 parts, magnesium chloride 10 parts, potassium chloride 3.2 parts, sodium chloride 0.2 parts 10 parts of sodium dihydrogen phosphate and 6 parts of tripotassium citrate; 30 parts of guar gum hydrolyzate as dietary fiber; 0.5 part of yeast mix; 18 parts of citric acid as acidulant, 8 parts of malic acid and lactic acid 27.5 parts; 0.6 parts of ascorbic acid diglucoside; 0.30 parts of zinc gluconate; 0.03 parts of copper gluconate; 1.5 parts of fragrance were appropriately added and stirred. Water was added until the obtained mixed solution was 4000 parts, and the mixture was dissolved and dispersed until a uniform state was obtained.
　得られた溶液は、連続殺菌下後、１個当たり２００部となるように口栓付きのアルミパウチに充填し、９０℃で１０分間の容器殺菌処理を行った。前記容器殺菌処理の後、冷却することで、パウチ入りの半固形化栄養剤を製造した。 The obtained solution was subjected to continuous sterilization, filled in an aluminum pouch with a stopper so that the amount was 200 parts per piece, and subjected to container sterilization at 90 ° C. for 10 minutes. After the container sterilization treatment, a semi-solidified nutrient containing a pouch was produced by cooling.
　（実施例２）
　タンパク質源を、ＷＰＣ３９２（ホエイプロテインコンセントレート：Ｆｏｎｔｅｒｒａ社製）１２０部および大豆たんぱく３０部に変更したことを除いては、実施例１と同様の方法により半固形化栄養剤を製造した。 (Example 2)
A semi-solid nutrient was produced in the same manner as in Example 1 except that the protein source was changed to 120 parts of WPC392 (whey protein concentrate: manufactured by Fonterra) and 30 parts of soy protein.
　（実施例３）
　寒天の添加量を２０部、ペクチンの添加量を４部、ローカストビーンガムの添加量を１０部、大豆多糖類の添加量を２．５部、およびグアガムの添加量を１．５部に変更したことを除いては、実施例１と同様の方法により半固形化栄養剤を製造した。 (Example 3)
20 parts agar added, 4 parts pectin added, 10 parts locust bean gum added, 2.5 parts soy polysaccharide added, and 1.5 parts guar gum added A semi-solidified nutrient was produced in the same manner as in Example 1 except that.
　（比較例１）
　寒天の添加量を４０部、ペクチンの添加量を１．５部、ローカストビーンガムの添加量を０．５部、大豆多糖類の添加量を２部、およびグアガムの添加量を０．５部に変更したことを除いては、実施例１と同様の方法で半固形化栄養剤を製造した。 (Comparative Example 1)
40 parts of agar, 1.5 parts of pectin, 0.5 parts of locust bean gum, 2 parts of soy polysaccharide, and 0.5 parts of guar gum A semi-solidified nutrient was produced in the same manner as in Example 1 except that the content was changed to.
　（比較例２）
　寒天の添加量を２０部、ペクチンの添加量を１５部、ローカストビーンガムの添加量を２０部、大豆多糖類の添加量を１０部、およびグアガムの添加量を１０部に変更したことを除いては、実施例１と同様の方法で半固形化栄養剤を製造した。 (Comparative Example 2)
Except for the addition of 20 parts of agar, 15 parts of pectin, 20 parts of locust bean gum, 10 parts of soy polysaccharide, and 10 parts of guar gum The semi-solidified nutrient was produced in the same manner as in Example 1.
　［半固形化栄養剤の評価］
　実施例および比較例で得られたそれぞれの半固形化栄養剤について下記の評価を行った。 [Evaluation of semi-solidified nutrients]
The following evaluation was performed about each semi-solidified nutrient obtained in the Example and the comparative example.
　＜離水率＞
　半固形化栄養剤２００ｇを６０メッシュ（目開き３００μｍ：ＪＩＳ規格用　ＴＥＳＴ‐ＳＩＥＶＥ）のふるいに静置し室温（２５℃）で放置した。３０分後、ふるいから通過した液体量（離水量）の重量を測定し、半固形化栄養剤２００ｇに対する離水量の割合を下記式により算出した。 <Water separation rate>
200 g of the semi-solidified nutrient was left on a sieve of 60 mesh (300 μm opening: TEST-SIEVE for JIS standard) and left at room temperature (25 ° C.). After 30 minutes, the weight of the liquid amount (water separation amount) that passed through the sieve was measured, and the ratio of the water separation amount to 200 g of the semi-solidified nutrient was calculated according to the following formula.
Figure JPOXMLDOC01-appb-M000001
Figure JPOXMLDOC01-appb-M000001
　上記離水率の評価は、２５℃で２４時間静置した半固形化栄養剤、および７ヵ月半の保存を想定した加速試験（４０℃で４週間静置）を行った半固形化栄養剤の両方について行った。 The evaluation of the water separation rate is based on a semi-solidified nutrient that was allowed to stand for 24 hours at 25 ° C and a semi-solidified nutrient that was subjected to an accelerated test (stable for 4 weeks at 40 ° C) that assumed storage for 7 months and a half. I went for both.
　＜粘度＞
　Ｂ型粘度計ＤＶ－ＩＩ＋Ｐｒｏ（ブルックフィールド社製）を用いて半固形化栄養剤の粘度を測定した。測定は、室温（２５℃）、回転速度６ｒｐｍの条件で、１分間行った。 <Viscosity>
The viscosity of the semi-solidified nutrient was measured using a B-type viscometer DV-II + Pro (manufactured by Brookfield). The measurement was performed for 1 minute under conditions of room temperature (25 ° C.) and a rotation speed of 6 rpm.
　＜熱量＞
　一般的なエネルギー換算係数、すなわち、糖質を４ｋｃａｌ／ｇ、タンパク質源を４ｋｃａｌ／ｇ、脂質を９ｋｃａｌ／ｇ、および食物繊維を２ｋｃａｌ／ｇに基づき、下記式によって半固形化栄養剤の熱量を算出した。 <Amount of heat>
Based on the general energy conversion factor, namely 4 kcal / g for carbohydrates, 4 kcal / g for protein source, 9 kcal / g for lipids, and 2 kcal / g for dietary fiber, Calculated.
Figure JPOXMLDOC01-appb-M000002
Figure JPOXMLDOC01-appb-M000002
　＜ｐＨ＞
　ｐＨ測定器ＭＥＴＴＬＥＲ　ＴＯＬＥＤＯ　ＭＰ２２０（ＭＥＴＴＬＥＲ　ＴＯＬＥＤＯ社）を用いて半固形化栄養剤のｐＨを測定した。 <PH>
The pH of the semi-solidified nutrient was measured using a pH meter METTLER TOLEDO MP220 (METTTLER TOLEDO).
　＜性状＞
　目視で半固形化栄養剤の性状を判断した。 <Properties>
The property of the semi-solidified nutrient was visually determined.
　○：容器から吐出した際の栄養剤が、滑らかなクリーム状を有する
　△：容器から吐出した際の栄養剤にわずかなザラツキ、部分的な凝集が見られる
　×：容器から吐出した際の栄養剤に大きな凝集物や塊が見られる。 ○: Nutrient when ejected from the container has a smooth cream state △: Slight roughness and partial aggregation are observed in the nutrient when ejected from the container ×: Nutrient when ejected from the container Large aggregates and lumps are seen.
　＜べたつき＞
　半固形化栄養剤を充填した５０ｍＬのカテーテルチップシリンジを内径４ｍｍのチューブに接続し、シリンジから半固形化栄養剤の全量を押出した後、チューブ中に付着した半固形化栄養剤の洗浄性の程度によって、べたつきを評価した。なお、べたつきの評価は下記の基準に従って行った。 <Stickiness>
A 50 mL catheter tip syringe filled with a semi-solid nutrient is connected to a tube with an inner diameter of 4 mm, and the entire amount of the semi-solid nutrient is extruded from the syringe. Stickiness was evaluated according to the degree. The stickiness was evaluated according to the following criteria.
　○：２０ｍＬの水でチューブ内の洗浄が完了する
　×：４０ｍＬの水で洗浄してもチューブ内に半固形化栄養剤が残存する。 ○: Washing in the tube is completed with 20 mL of water. ×: Semi-solidified nutrient remains in the tube even after washing with 40 mL of water.
　実施例１～３および比較例１～２の半固形化栄養剤についての上記評価結果を、各成分の含有量とともに表１に示す。 The above evaluation results for the semi-solidified nutrients of Examples 1 to 3 and Comparative Examples 1 to 2 are shown in Table 1 together with the content of each component.
Figure JPOXMLDOC01-appb-T000003
Figure JPOXMLDOC01-appb-T000003
　表１の結果から明らかなように、実施例の半固形化栄養剤は、所定量のペクチン、ローカストビーンガム、大豆多糖類、およびグアガムからなる群より選択される少なくとも１種を含有することにより、離水の発生が抑制され、滑らかなクリーム状の性状を保持できていることが分かる。 As is clear from the results in Table 1, the semi-solidified nutrients of the examples contain a predetermined amount of at least one selected from the group consisting of pectin, locust bean gum, soybean polysaccharide, and guar gum. It can be seen that the occurrence of water separation is suppressed and the smooth cream-like properties can be maintained.

Claims (4)

  1. 　糖質およびタンパク質源を含む栄養素と、
    　水分と、寒天と、ペクチン、ローカストビーンガム、大豆多糖類、およびグアガムからなる群より選択される少なくとも１種の増粘剤と、を少なくとも含む半固形化栄養剤であって、
    　前記寒天の含有量が栄養剤全量に対して０．１～０．８質量％であり、
    　前記増粘剤の含有量が栄養剤全量に対して０．２～１．０質量％である、半固形化栄養剤。     Nutrients including carbohydrate and protein sources;
    A semi-solid nutrient containing at least water, agar, and at least one thickener selected from the group consisting of pectin, locust bean gum, soybean polysaccharide, and guar gum,
    The content of the agar is 0.1 to 0.8% by mass with respect to the total amount of the nutrient,
    A semi-solidified nutrient in which the content of the thickener is 0.2 to 1.0 mass% with respect to the total amount of the nutrient.
  2. 　２５℃での粘度が１０，０００～５０，０００ｍＰａ・ｓである、請求項１に記載の半固形化栄養剤。 The semi-solidified nutrient according to claim 1, wherein the viscosity at 25 ° C is 10,000 to 50,000 mPa · s.
  3. 　熱量が０．５～２．５ｋｃａｌ／ｇである、請求項１または２に記載の半固形化栄養剤。 The semi-solidified nutrient according to claim 1 or 2, wherein the calorific value is 0.5 to 2.5 kcal / g.
  4. 　ｐＨが３．０～４．５である、請求項１～３のいずれか１項に記載の半固形化栄養剤。 The semi-solidified nutrient according to any one of claims 1 to 3, wherein the pH is 3.0 to 4.5.
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