JP2019210259A - Liquid nutrient supplement composition - Google Patents

Abstract

To provide liquid nutrient supplement compositions that are in a presterilized state, have excellent formulation dispersibility, and have a good flavor, while containing vitamins, trace minerals, and vitamin-like substances in order to deal with deficiency of vitamins, trace minerals, and vitamin-like substances and to supplement these, and being in liquid form allowing administration by tube similarly to tube feeding, in addition to oral administration.SOLUTION: The subject is solved by a liquid nutrient supplement composition containing vitamins, trace minerals, and vitamin-like substances, the composition containing 0.05 to 0.20% (w/v) of agar with a jelly strength of 20 to 80 g/cm, and 0.1 to 0.3% (w/v) of thickening polysaccharide, the calorie being 0.05 to 1.0 kcal/mL, the pH being 3.0-4.5, the viscosity being 10-30 mPa s, the osmotic pressure being 250 to 350 mOsm/kg.SELECTED DRAWING: None

Description

  The present invention relates to a liquid nutrient supplement composition.

  Vitamins and trace minerals are maintained and adjusted in a physiologically optimal concentration range in a well-balanced manner in order to maintain normal vital functions. Vitamin-like substances are compounds that can be synthesized in the body and exert actions similar to the action of vitamins on the human body. However, when the balance breaks down due to deficiency or excess, and homeostasis is lost, excessive accumulation and deficiency of specific elements are induced, and specific diseases are induced.

  Usually vitamins, trace minerals and vitamin-like substances do not cause deficiency in a well-balanced diet. However, if nutrition is not properly ingested or administered due to unbalanced diet, tube feeding, parenteral nutrition, chronic diarrhea, etc., deficiency tends to occur due to insufficient intake. For example, there are tube feeding agents and high-calorie infusion agents that do not contain selenium, which is a trace mineral, or carnitine, which is a vitamin-like substance (Patent Documents 1 and 2). If these are used, they may become deficient unless they are properly supplemented with selenium or carnitine. There may also be a risk of deficiencies other than selenium and carnitine.

  For such deficiencies, it is necessary to supplement vitamins, trace minerals, and vitamin-like substances. Changes are required.

  There is also a method to prepare and supplement a nutrient supplement composition containing necessary vitamins, trace minerals, and vitamin-like substances separately from tube feeding agents, etc. In particular, it was difficult to produce a product having good dispersibility and good flavor.

JP2013-199491A JP 02-083327 A

  Therefore, the present invention is supplemented with vitamins, trace minerals, and vitamin-like substances in order to supplement these vitamins. Another object is to obtain a liquid nutrient supplement composition that is liquid and can be administered by tube, but has been disinfected in advance and has good dispersibility and good flavor.

  The above problems are solved by the present invention described below.

(1) The present invention is a composition containing vitamins, trace minerals, and vitamin-like substances, and 0.05 to 0.20 mass% (w / v) of agar having a jelly strength of 20 to 80 g / cm ^2. ), Containing 0.1 to 0.3% by mass (w / v) of thickening polysaccharide, with a calorific value of 0.05 to 1.0 kcal / mL, a pH of 3.0 to 4.5, and a viscosity of 10 to 10. It is a liquid nutrient replenishment composition having an osmotic pressure of 250 to 350 mOsm / kg at 30 mPa · s.

  (2) The present invention comprises 0.01 to 2000 mg of the vitamin, 0.1 μg to 55 mg of the trace mineral, and 10 mg to 1000 mg of the vitamin-like substance with respect to 100 mL of the liquid nutrient supplement composition. The liquid nutrient supplement composition according to (1) above.

  (3) The liquid nutrient supplement composition according to (1) or (2), wherein the present invention contains 0.1 to 500 μg of selenium as the trace mineral with respect to 100 mL of the liquid nutrient supplement composition. It is a thing.

  (4) The liquid nutrient according to any one of (1) to (3), wherein the present invention contains 10 to 1000 mg of carnitine as the vitamin-like substance with respect to 100 mL of the liquid nutrient supplement composition. Replenishment composition.

  (5) The liquid nutrient according to any one of (1) to (4), wherein the present invention contains 10 to 1000 mg of inositol as the vitamin-like substance with respect to 100 mL of the liquid nutrient supplement composition. Replenishment composition.

  (6) The liquid nutrient supplement composition according to any one of (1) to (5) above, wherein the vitamin-like substance contains 10 to 1000 mg of choline.

  (7) The present invention relates to 100 mL of the above liquid nutrient supplement composition, as the vitamin, 0.01-40 mg of vitamin B1, 0.01-20 mg of vitamin B2, 0.1-300 mg NE of niacin, vitamin B6 0.01-60 mg, vitamin B12 0.01-100 μg, folic acid 1-1000 μg, pantothenic acid 0.1-55 mg, biotin 0.1-500 μg, vitamin C (ascorbic acid) 1-2000 mg, As said trace mineral, 0.1-55 mg of iron, 0.1-50 mg of zinc, 0.01-20 mg of copper, 0.01-15 mg of manganese, 0.1-3500 μg of iodine, 0.1 of chromium The liquid nutrient supplement according to any one of (1) to (6) above, which comprises ˜50 μg and 0.1 to 350 μg of molybdenum It is a formed product.

  (8) The liquid nutrient supplement composition according to any one of (1) to (7), wherein the thickening polysaccharide is carrageenan, gellan gum, or guar gum.

  (9) The liquid nutrient replenishment composition according to any one of (1) to (8), which is sterilized in advance.

  According to the present invention, micronutrients that are deficient in nutrients ingested or administered by normal enteral or parenteral nutrition can be supplemented by oral ingestion or tube administration, and dispersed in a pharmaceutical manner. It is possible to provide a liquid nutrient supplement composition having good properties and good flavor.

  Hereinafter, the present invention will be described in detail. In this specification, “part” or “%” is used, but “part by mass” or “% by mass” is expressed unless otherwise specified.

The present invention is a composition containing vitamins, trace minerals, and vitamin-like substances, 0.05 to 0.20% by mass of agar having a jelly strength of 20 to 80 g / cm ² and 0% thickening polysaccharide. 0.1 to 0.5%, heat quantity is 0.05 to 1.0 kcal / mL, pH is 3.0 to 5.0, viscosity is 10 to 30 mPa · s, and osmotic pressure is 200 to 400 mOsm / kg. It is a liquid nutrient supplement composition.

The agar of the present invention is not particularly limited as long as it has a jelly strength of 20 to 80 g / cm ² , and a conventionally known one can be used. If the jelly strength of the agar is less than 20 g / cm ² , the solid content of the liquid nutrient replenishment composition may be precipitated without being dispersed and the throat may be deteriorated. On the other hand, if the jelly strength of the agar exceeds 70 g / cm ² , the viscosity of the liquid nutrient replenishment composition increases, which may make administration and ingestion difficult.

The jelly strength is measured according to the method adopted by Japan Agar Manufacturing and Fisheries Association. The jelly strength of the agar of this method was measured per 1 cm ^{2 of} agar obtained by solidifying the 1.5% solution at 20 ° C. for 15 hours using a jelly strength measuring instrument (Nissui Water, Fuji Rika Kogyo Co., Ltd.). Maximum weight for 20 seconds.

  The blending amount of the agar of the present invention is 0.05 to 0.20%, preferably 0.7 to 1.3%, more preferably 0.9 to 1.0% with respect to the total amount of the liquid nutrient supplement composition. 0%. If the amount of the agar is less than 0.05%, the solid content of the nutrient replenishing composition may be precipitated without being dispersed and the throat may be deteriorated. If the amount of the agar exceeds 0.20% In addition, the viscosity of the liquid nutrient supplement composition may increase, making it difficult to administer and ingest.

  As the thickening polysaccharide of the present invention, any of various known materials conventionally used in nutritional compositions can be used. Specifically, pectin, carrageenan, gellan gum, guar gum, alginic acid, cellulose, hemicellulose, lignin, chitin, chitosan, indigestible dextrin, inulin, psyllium seed coat, guar gum degradation product, konjac mannan, glucomannan, polydextrose, carrageenan, Examples include wheat bran, resistant starch, fucoidan, tamarind seed gum, pullulan, gellan gum and gum arabic. These thickening polysaccharides may be used alone or in admixture of two or more.

  The compounding quantity of the thickening polysaccharide of this invention is 0.1 to 0.5% with respect to the whole quantity of a nutrient supplement composition. If the blending amount of the thickening polysaccharide is less than 0.1%, the solid content of the liquid nutrient replenishment composition is not sufficiently dispersed, and the ingestion may worsen when ingested. Moreover, when the compounding quantity of thickening polysaccharide exceeds 0.5%, there exists a possibility that the viscosity of a liquid nutrient replenishment composition may rise and it may become difficult to administer and ingest.

  The viscosity of the liquid nutrient supply composition of the present invention is 10 to 30 mPa · s, preferably 15 to 25 mPa · s. If the viscosity is less than 10 mPa · s, precipitation may occur when the liquid nutrient supplement composition is stored. Moreover, when a viscosity exceeds 30 mPa * s, when a nutrient supplement composition is ingested, there is a possibility that a throat will be inferior and a flavor may worsen.

  The viscosity of the liquid nutrient supplement composition of the present invention is measured according to the method described in the Ninth Edition Food Additives Official Document “B. General Test Method, 30. Viscosity Measurement Method Second Method Rotational Viscometer Method”. The For example, the value measured using B-type rotational viscometer DV-II + Pro (Brookfield), RB80L (Toki Sangyo Co., Ltd.), etc.

  The calorie | heat amount of the liquid nutrient replenishment composition of this invention is 0.05-1.0 kcal / mL, Preferably it is 0.6-0.9 kcal / mL. If the calorific value is less than 0.05 kcal / mL, the moisture of the nutrient supplement composition increases, and there is a risk that nutrients administered to the patient will be reduced and nutrition will be insufficient. In addition, when the calorie exceeds 1.0 kcal / g, the calorie of the liquid nutrient supplement composition increases, and there is a possibility that the calorie may be excessive in excess of the calorie previously planned for tube feeding or high calorie infusion. is there. The amount of heat can be adjusted by appropriately setting the addition amount of carbohydrates, lipids, proteins, thickening polysaccharides and the like. In the present specification, the “heat amount” is a value calculated with reference to Atwater's energy conversion coefficient. Specifically, calorific value = (4 kcal × carbohydrate content) + (9 kcal × lipid content) + (4 kcal × protein content) + (2 kcal × dietary fiber content (including thickening polysaccharide)) It is shown as a hit kcal.

  The osmotic pressure of the liquid nutrient supplement composition of the present invention is 200 to 400 mOsm / kg, preferably 250 to 350 mOsm / kg. When the osmotic pressure is less than 200 mOsm / kg, when the nutrient supplement composition is ingested, the nutrient may not be absorbed. In addition, when the osmotic pressure exceeds 400 mOsm / kg 30 mPa · s, when the liquid nutrient supplement composition is ingested, diarrhea may occur, and the flavor may deteriorate.

  The osmotic pressure of the liquid nutrient supplement composition of the present invention is measured according to the method described in the 14th revision Japanese Pharmacopoeia “General Test Method, 30. Osmotic Pressure Measurement Method”. For example, it means a value measured using an osmotic pressure measuring device 3900 (ADVANCE).

  The pH of the liquid nutrient supply composition according to the present invention is 3.0 to 5.0, preferably 3.5 to 4.5. If the pH is less than 3.0, the acidity may become too strong. Moreover, when pH exceeds 5.0, since an amine odor may be conspicuous, a flavor worsens and is unpreferable. In addition, pH of the liquid nutrient replenishment composition of this invention can be adjusted by setting suitably the addition amount, such as a pH adjuster and a sour agent. Moreover, pH of the liquid nutrient supplement composition of this invention is the value measured according to the method described in the 9th edition food additive official standard "B. General test method, 31. pH measurement method."

  Vitamins to be blended in the liquid nutrient supplement composition according to the present invention include vitamin B1, vitamin B2, niacin, vitamin B6, vitamin B12, folic acid, pantothenic acid, biotin, vitamin C, and the like. It is preferable to blend them. As the vitamin, vitamin derivatives (for example, salts such as hydrochloride and calcium salt) may be used. Moreover, you may mix | blend vitamin A, vitamin D, vitamin E, and vitamin K.

  Vitamin B1 is 0.01-40 mg, preferably 0.1-10 mg, and vitamin B2 is 0.01-20 mg, preferably 100 mL of the liquid nutrient supplement composition of the present invention. 0.05-10 mg, niacin is 0.1-300 mg NE, preferably 0.5-60 mg NE, vitamin B6 is 0.01-60 mg, preferably 0.1-30 mg, vitamin B12 is 0.01-100 μg , Preferably 0.2-60 μg, folic acid 1-1000 μg, preferably 10-200 μg, pantothenic acid 0.1-55 mg, preferably 0.2-30 mg, biotin 0.1-500 μg, preferably Is 1 to 100 μg, and vitamin C is 1 to 2000 mg, preferably 5 to 1000 mg.

  Examples of the trace mineral according to the present invention include iron, zinc, copper, manganese, iodine, selenium, chromium, and molybdenum, and it is preferable to combine a plurality of these as much as possible. These trace minerals may be blended as an inorganic electrolyte component or may be blended as an organic electrolyte component. Examples of the inorganic electrolyte component include alkali metal or alkaline earth metal salts such as chlorides, sulfates, carbonates, and phosphorus oxides. Examples of the organic electrolyte component include organic acids such as citric acid, lactic acid, amino acids (for example, glutamic acid and aspartic acid), malic acid and gluconic acid. In addition, iron, zinc, copper, manganese, iodine, selenium, chromium, and molybdenum are trace mineral-containing microorganisms derived from microorganisms that are obtained by culturing in a medium containing a high concentration of trace mineral compounds. The body may be used. Furthermore, a trace mineral mixture derived from seaweed or the like can also be used.

  The amount of the trace mineral according to the present invention is 0.1 to 55 mg, preferably 1 to 10 mg for iron, 0.1 to 50 mg, preferably 1 to 15 mg for zinc, and 1 to 15 mg for copper per 100 mL of liquid nutrient supplement composition. 0.01-50 mg, preferably 0.06-6 mg, manganese is 0.01-15 mg, preferably 0.1-4 mg, iodine is 0.1-3500 μg, preferably 1-150 μg, selenium is 0.1 to 500 μg, preferably 1 to 100 μg, chromium is 0.1 to 50 μg, and molybdenum is 0.1 to 350 μg.

  The vitamin-like substance of the present invention is an important substance similar to vitamins in the body, but can be synthesized in the body and does not cause deficiency. Specifically, carnitine, inositol, choline and the like can be mentioned, and it is preferable to mix one or more of these in combination.

  The amount of the vitamin-like substance of the present invention is 10 to 1000 mg, preferably 20 to 1000 mg for carnitine, preferably 10 to 1000 mg, preferably 20 to 1000 mg for inositol, and 10 to 1000 mg for choline per 100 mL of liquid nutrient supplement composition. A range of 1000 mg, preferably 20 to 1000 mg is suitable.

  Moreover, in this invention, you may mix | blend saccharide | sugar (except a thickening polysaccharide), protein, and a lipid as follows.

  As the saccharide (excluding the thickening polysaccharide) that can be used in the present invention, any of known polysaccharides, sugar alcohols, saccharides, and the like conventionally used in nutritional compositions can be used. For example, glucose (glucose), fructose (fructose), monosaccharides such as galactose, sucrose (sucrose), lactose (lactose), maltose (maltose), isomaltose, trehalose and other disaccharides, starch (amylose, amylopectin), Polysaccharides such as dextrin, starch syrup, reduced starch syrup, honey, isomerized sugar, invert sugar, digestible oligosaccharide, powdered sugar, sugar alcohol (maltitol, sorbitol, isomaltulose, isomaltulose reduced product, xylitol, lactitol, etc. ), Sugar-bound starch syrup (coupling sugar) and the like. These may be used individually by 1 type and may combine 2 or more types.

  The compounding quantity of the saccharide | sugar in the liquid nutrient supplement composition which concerns on this invention can be used within the range of the calorie | heat amount mentioned above.

  As the proteins (including amino acids and peptides) that can be used in the present invention, any of various known proteins (amino acids, peptides, plant proteins, animal proteins) conventionally used in nutritional compositions can be used.

  Amino acids include essential amino acids such as valine, leucine, isoleucine, lysine, methionine, phenylalanine, threonine, tryptophan, histidine; and glycine, alanine, serine, cysteine, asparagine, glutamine, proline, tyrosine, aspartic acid, glutamic acid, arginine, etc. Of the non-essential amino acids. In addition to these, modified amino acids such as 4-hydroxyproline, 5-hydroxylysine, γ-carboxyglutamic acid, O-phosphoserine, O-phosphotyrosine, N-acetylserine, Nω-methylarginine, pyroglutamic acid, M-formylmethionine; ornithine , Citrulline, γ-aminobutyric acid (GABA), thyroxine, S-adenylmethionine and other special amino acids may also be included. The amino acids may be stereoisomers (enantiomers, diastereomers), positional isomers, or a mixture thereof. Further, the amino acid may be in the form of an inorganic acid salt (hydrochloride, etc.), an organic acid salt (acetate, etc.), a hydrolyzable ester (methyl ester, etc.), a hydrate, etc. .

  Peptides include those in which two or more residues of the above amino acids are polymerized via peptide bonds (amide bonds). The peptide may be a dipeptide, a tripeptide, an oligopeptide (having about 10 amino acids), or a polypeptide (having several tens to several hundred amino acids).

  Examples of plant proteins include proteins contained in grains such as rice, corn and wheat, and beans such as soybeans.

  Examples of animal proteins include proteins contained in eggs, meats, seafood, milk and the like. Among these, it is preferable to use whey protein, casein protein, and soy protein made from milk (whey). As the protein, commercially available protein materials such as whey protein concentrate (WPC), whey protein isolate (WPI), hydrolyzed whey peptide (WPH), soybean protein and the like may be used.

  The above proteins, amino acids or peptides may be used alone or in admixture of two or more.

  The compounding amount of the amino acid, peptide, or protein in the liquid nutrient supplement composition according to the present invention can be used within the above-mentioned range of heat.

  As the lipid that can be used in the present invention, any of various known lipids conventionally used in nutritional compositions can be used.

  For example, linseed oil, sesame oil, olive oil, sesame oil, rice oil, safflower oil, perilla oil, soybean oil, corn oil, rapeseed oil, germ oil, palm oil, palm kernel oil, sunflower oil, cottonseed oil, palm oil, Vegetable oils such as peanut oil, animal fats such as fish oil and milk, microalgae such as Schizochytrium, filamentous fungi such as Mortierella, microbial oils derived from yeast, medium chain fatty acids, highly unsaturated fatty acids (for example, arachidon) And fatty acids such as acid, DHA, and EPA). These may be used individually by 1 type and may combine 2 or more types. In addition, processed preparations such as diacylglycerol can also be added.

  The compounding quantity in the liquid nutrient supplement composition which concerns on this invention can be used within the range of the calorie | heat amount mentioned above.

  The liquid nutrient supplement composition according to the present invention may further contain other known components such as food additives as long as the object and effects of the present invention are achieved.

  The food additive is used for the purpose of processing or storing the food by adding, mixing, moistening or other methods to the food. Examples of the food additive include an antioxidant, a colorant, a sweetener, a pH adjuster, a sour agent, a fragrance, and a cyclodextrin other than the purpose of enhancing nutrition.

  The antioxidant has a function of preventing deterioration of the liquid nutrient supplement composition due to oxidation. The antioxidant is not particularly limited, and examples thereof include erythorbic acid and its sodium salt. These antioxidants may be used alone or in combination of two or more.

  The colorant has a function of coloring the liquid nutrient supplement composition. Although it does not restrict | limit especially as a coloring agent, Edible tar pigment | dye (Edible red No. 2, No. 3, No. 40, No. 102, No. 104, No. 105, and No. 106, Edible blue No. 1 and No. 2, Edible yellow No. 4 And No. 5, Edible Green No. 3, etc.), β-carotene, water-soluble anato, chlorophyll derivatives (chlorophyll a, chlorphyll b, copper chlorophyll, copper chlorophyllin sodium, iron chlorophyllin sodium, etc.), riboflavin, iron sesquioxide, titanium dioxide , Safflower yellow pigment, cochineal pigment, gardenia yellow pigment, turmeric pigment, red cabbage pigment, beet red, grape skin pigment, paprika pigment, caramel and the like. These colorants may be used alone or in admixture of two or more.

  The sweetener has a function of imparting sweetness to the liquid nutrient supplement composition. The sweetener is not particularly limited, and examples thereof include aspartame and acesulfame potassium. These sweeteners may be used alone or in combination of two or more.

  The pH adjuster has a function of adjusting the pH of the liquid nutrient supplement composition. Although it does not restrict | limit especially as a pH adjuster, Citric acid, gluconic acid, succinic acid, potassium carbonate, sodium hydrogencarbonate, lactic acid, sodium lactate, sodium citrate, adipic acid, sodium hydroxide etc. are mentioned. These pH adjusters may be used alone or in combination of two or more.

  The acidulant has functions such as imparting acidity to the liquid nutrient supplement composition, preventing oxidation of the food, and adjusting the pH. The acidulant is not particularly limited, and acetic acid, citric acid, succinic acid, lactic acid, malic acid, tartaric acid, gluconic acid, phosphoric acid and the like can be used. These acidulants may be used alone or in combination of two or more.

  The fragrance has a function of flavoring and smelling the liquid nutrient supplement composition. The fragrance is not particularly limited, but acetophenone, α-amylcinnamaldehyde, anisaldehyde, benzaldehyde, benzyl acetate, benzyl alcohol, cinnamaldehyde, cinnamic acid, citral, citronellal, citronellol, decanal, decanol, ethyl acetoacetate, silica Ethyl cinnamate, ethyl decanoate, ethyl vanillin, eugenol, geraniol, isoamyl acetate, isoamyl butyrate, isoamyl phenyl acetate, dl-menthol, l-menthol, methyl salicylate, piperonal, propionic acid, terpineol, vanillin, d-borneol, etc. Can be mentioned. These fragrances may be used alone or in combination of two or more.

  The liquid nutrient supplement composition according to the present invention can be produced by a known method. For example, it can manufacture by adding the substance and component mentioned above to warm water, and stirring.

  The liquid nutrient supplement composition of the present invention is preferably sterilized. Although it does not restrict | limit especially as a method of sterilization, Ultra high temperature short time (UHT) sterilization, hot water sterilization, batch type sterilization, and these combination are mentioned. The sterilization is preferably performed in a short time. By performing sterilization in a short time, it is possible to suppress deterioration of the components contained in the nutrient supplement composition.

  It does not specifically limit as a container filled with the liquid nutrient replenishment composition of this invention, A well-known container may be used. Examples of the container include a tetrapack, a cart can, a glass container, a metal can, an aluminum pouch, and a plastic container. Of these, it is preferable to use a plastic container.

  As a raw material of the plastic container, polyethylene (PE), polypropylene (PP), polyvinyl chloride (PVC), polyvinyl acetate (PVAc), polycarbonate (PC), polybutylene terephthalate (PBT), polyethylene terephthalate (PET), Polyethylene naphthalate (PEN), ethylene-vinyl acetate copolymer (EVA), ethylene-α-olefin copolymer, polyfluorocarbon, polyimide and the like are preferably used.

  The container may be further shielded from light. By the light shielding, for example, deterioration due to light of vitamin A, vitamin B2, vitamin C, vitamin K and the like which can be blended in the nutrient supplement composition can be suppressed.

  The above-mentioned container may use what is marketed, for example, a soft pouch (Fuji Seal Co., Ltd.), a bottled pouch (Toppan Printing Co., Ltd.), a spouch (Dai Nippon Printing Co., Ltd.), a cheer pack (Yoyuki Hosokawa Co., Ltd.). Etc. can be used.

  EXAMPLES Hereinafter, the present invention will be specifically described with reference to examples, but the present invention is not limited thereto.

(Example 1)
The preparation method is described below. In addition, the compounding quantity of each raw material is as showing in Table 1.

1000 L of water was weighed in a 6000 L tank and heated to 85 ° C. Next, agar (jelly strength: 30 g / cm ² , blending amount: 0.09%, w / v), thickening polysaccharide (pectin, blending amount: 0.05%, w / v, locust bean gum, blending amount : 0.15%, w / v, total: 0.2 w / v), sucralose was added and dissolved sufficiently, and then citric acid and trisodium citrate were added. Furthermore, apple concentrated fruit juice, iron citrate, zinc gluconate, copper gluconate, manganese yeast, selenium yeast, chromium yeast, and kelp extract were mixed. After cooling to 25 ° C., a water-soluble vitamin mix (shown in Table 2), ascorbic acid, and a flavor were added and stirred. Water was added until the total amount became 4000 L, and the mixture was dissolved and dispersed until a uniform state was obtained. The obtained solution was homogenized and UHT sterilized, and aseptically filled in a tetra container so as to be 125 mL per one. After the container sterilization treatment, the liquid nutrient supplement composition was produced by cooling.

  The calorific value is calculated as (4 kcal × sugar content) + (9 kcal × lipid content) + (4 kcal × protein content) + (2 kcal × dietary fiber content (including thickening polysaccharide)) Are shown in Tables 3 to 9 below.

  The obtained liquid nutrient supplement composition was measured for pH, viscosity and osmotic pressure, and further evaluated for stability and flavor. The calorific value was 0.16 kcal / mL, the pH was 3.40, the viscosity was 22 mPa · s, The osmotic pressure was 270 mOsm / kg, the stability was ◎, and the flavor was ◎. These results are shown in Table 3 below. Various evaluation methods are as follows.

  (1) pH: Measured with a pH meter (manufacturer: Horiba, Ltd., model: F-21).

  (2) Viscosity: Using nutrient replenishment composition at 20 ° C. and B-type rotational viscometer (manufacturer: BROOKFIELD, model: DV-II + Pro, measurement conditions: rotor No. 61, rotational speed 60 rpm, measurement time 1 minute) Measured.

  (3) Osmotic pressure: Measured using an osmometer (ADVANCED, model: 3900).

  (4) Flavor: For the panelists (9 men, 3 women, average age 38 years)), based on the liquid nutritional supplement composition produced from Example 1 without blending the vitamin-like substance carnitine , Comparing the preference with the liquid nutrient supplement composition produced in each of the examples and comparative examples according to the following criteria, if the judgment of “Yes” is 10 or more, “◎”, “Yes” The case of 9 to 5 persons was designated as “◯”, and the case where the judgment of “possible” was 4 or less was designated as “X”.

  Good: Compared with the liquid nutrient supplement composition produced without blending carnitine, the flavor was as good as or better than that and it was ingestible.

  Impossibility: Compared with the liquid nutrient supplement composition produced without blending carnitine, the flavor was worse than that, and the intake was impossible.

(5) Stability: After standing for 2 weeks after production, the stability of the liquid nutrient replenishment composition was visually determined according to the following criteria:
A: Dispersibility was good, no precipitate was formed, and it was stable.

  ○: Dispersibility was slightly inferior and some precipitates were formed, but they were stable.

  X: Dispersibility was poor, a precipitate was formed, and it was unstable.

(Example 2)
In Example 1, the jelly strength of agar is 20 g / cm ² , the agar content is 0.05%, the thickening polysaccharide content is 0.025% pectin, and locust bean gum 0.075% (total: 0) A liquid nutrient supplement composition was produced in the same manner as in Example 1 except that the content was changed to 0.1%.

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 3.42, a viscosity of 11 mPa · s, an osmotic pressure of 265 mOsm / kg, a stability of ◎, and a flavor of ◎. These results are shown in Table 3 below.

(Example 3)
In Example 1, the agar jelly strength was 80 g / cm ² , the agar content was 0.2%, the thickening polysaccharide content was 0.075% pectin, and locust bean gum 0.225% (total: 0). A liquid nutrient supplement composition was produced in the same manner as in Example 1 except that the content was changed to 3%.

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 3.42, a viscosity of 35 mPa · s, an osmotic pressure of 281 mOsm / kg, a stability of ◎, and a flavor of 味. These results are shown in Table 3 below.

(Example 4)
In Example 1, the jelly strength of agar was 20 g / cm ² , the agar content was 0.05%, the thickening polysaccharide content was 0.075% pectin, and locust bean gum 0.225% (total: 0) A liquid nutrient supplement composition was produced in the same manner as in Example 1 except that the content was changed to 3%.

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 3.40, a viscosity of 18 mPa · s, an osmotic pressure of 272 mOsm / kg, a stability of ◎, and a flavor of ◎. These results are shown in Table 4 below.

(Example 5)
In Example 1, the jelly strength of agar is 80 g / cm ² , the agar content is 0.2%, the thickening polysaccharide content is 0.025% pectin, and locust bean gum 0.075% (total: 0) A liquid nutrient supplement composition was produced in the same manner as in Example 1 except that the content was changed to 0.1%.

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / 100 mL, a pH of 3.41, a viscosity of 31 mPa · s, an osmotic pressure of 275 mOsm / kg, a stability of ◎, and a flavor of ◎. These results are shown in Table 4 below.

(Example 6)
In Example 1, the agar jelly strength was 20 g / cm ² , the agar compounding amount was 0.2%, the thickening polysaccharide compounding amount was 0.025% pectin, and locust bean gum 0.075% (total: 0). A liquid nutrient supplement composition was produced in the same manner as in Example 1 except that the content was changed to 0.1%.

  The obtained liquid nutrient replenishment composition had a calorific value of 0.16 kcal / mL, a pH of 3.43, a viscosity of 15 mPa · s, an osmotic pressure of 272 mOsm / kg, a stability of ◎, and a flavor of ◎. These results are shown in Table 4 below.

(Example 7)
In Example 1, the jelly strength of agar is 80 g / cm ² , the agar content is 0.05%, the thickening polysaccharide content is 0.075% pectin, and locust bean gum 0.225% (total: A liquid nutrient supplement composition was produced in the same manner as in Example 1 except that the content was changed to 0.3%.

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 3.42, a viscosity of 28 mPa · s, an osmotic pressure of 277 mOsm / kg, a stability of ◎, and a flavor of ◎. These results are shown in Table 5 below.

(Example 8)
In Example 1, the jelly strength of agar was 80 g / cm ² , the agar content was 0.05%, the thickening polysaccharide content was 0.025% pectin, and locust bean gum 0.075% (total: 0) A liquid nutrient supplement composition was produced in the same manner as in Example 1 except that the content was changed to 0.1%.

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 3.41, a viscosity of 24 mPa · s, an osmotic pressure of 271 mOsm / kg, a stability of ◎, and a flavor of ◎. These results are shown in Table 5 below.

Example 9
In Example 1, the jelly strength of agar is 20 g / cm ² , the agar content is 0.2%, the thickening polysaccharide content is 0.075% pectin, and locust bean gum 0.225% (total: 0) A liquid nutrient supplement composition was produced in the same manner as in Example 1 except that the content was changed to 3%.

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 3.42, a viscosity of 15 mPa · s, an osmotic pressure of 276 mOsm / kg, a stability of ◎, and a flavor of ◎. These results are shown in Table 5 below.

(Example 10)
In Example 1, the liquid nutrient supplement composition was manufactured similarly to Example 1 except having changed the kind of thickening polysaccharide from locust bean gum to carrageenan.

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 3.40, a viscosity of 21 mPa · s, an osmotic pressure of 272 mOsm / kg, a stability of ◎, and a flavor of ◎. These results are shown in Table 6 below.

(Example 11)
In Example 1, the liquid nutrient supplement composition was manufactured similarly to Example 1 except having changed the kind of thickening polysaccharide from locust bean gum to guar gum.

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 3.40, a viscosity of 28 mPa · s, an osmotic pressure of 269 mOsm / kg, a stability of ◎, and a flavor of ◎. These results are shown in Table 6 below.

(Example 12)
In Example 1, a nutrient supplement composition was produced in the same manner as in Example 1 except that the vitamin-like substance was changed to inositol.

  The obtained nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 3.40, a viscosity of 21 mPa · s, an osmotic pressure of 271 mOsm / kg, a stability of ◎, and a flavor of ◎. These results are shown in Table 6 below.

(Example 13)
In Example 1, a liquid nutrient supplement composition was produced in the same manner as in Example 1 except that the vitamin-like substance was changed to choline.

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 3.41, a viscosity of 23 mPa · s, an osmotic pressure of 270 mOsm / kg, a stability of ◎, and a flavor of ◎. These results are shown in Table 7 below.

(Example 14)
In Example 1, a liquid nutrient supplement composition was produced in the same manner as in Example 1 except that the concentration of the vitamin-like substance was changed to 40 mg / 100 mL.

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 4.19, a viscosity of 22 mPa · s, an osmotic pressure of 303 mOsm / kg, a stability of ◎, and a flavor of ◎. These results are shown in Table 7 below.

(Example 15)
In Example 1, a liquid nutrient supplement composition was produced in the same manner as in Example 1 except that the concentration of the vitamin-like substance was changed to 800 mg / 100 mL.

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 4.24, a viscosity of 23 mPa · s, an osmotic pressure of 324 mOsm / kg, a stability of ◎, and a flavor of 味. These results are shown in Table 7 below.

(Comparative Example 1)
In Example 1, a liquid nutrient supplement composition was produced in the same manner as in Example 1 except that the blending amount of agar was changed to 0%.

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 3.40, an osmotic pressure of 268 mOsm / kg, a viscosity of 7 mPa · s, but a flavor of x, stability. Was x. These results are shown in Table 8 below.

(Comparative Example 2)
In Example 1, a liquid nutrient supplement composition was produced in the same manner as in Example 1 except that the jelly strength of the agar was changed to 100 g / cm ² .

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 3.45, an osmotic pressure of 272 mOsm / kg, a stability of ◎, a viscosity of 40 mPa · s, and a flavor of ×. It was. These results are shown in Table 8 below.

(Comparative Example 3)
In Example 1, the liquid nutrient supplement composition was manufactured similarly to Example 1 except having changed the compounding quantity of the thickening polysaccharide into 0%.

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 3.42, an osmotic pressure of 287 mOsm / kg, and a viscosity of 5 mPa · s, but the flavor was x and the stability was x. It was. These results are shown in Table 8 below.

(Comparative Example 4)
In Example 1, the amount of thickening polysaccharide was changed to pectin 0.1% (w / v) and locust bean gum 0.3% (w / v) (total: 0.4%, w / v) A liquid nutrient supplement composition was produced in the same manner as in Example 1 except that.

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 3.42, an osmotic pressure of 281 mOsm / kg, a stability of ◎, a viscosity of 31 mPa · s, and a flavor of ×. It was. These results are shown in Table 9 below.

(Comparative Example 5)
In Example 1, the liquid nutrient supplement composition was manufactured similarly to Example 1 except having changed the compounding quantity of the vitamin-like substance into 1200 mg / 100 mL.

  The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 4.51, a viscosity of 23 mPa · s, a stability of ◎, a flavor of ◯, and an osmotic pressure of 374 mOsm / kg. It was. These results are shown in Table 9 below.

(Comparative Example 6)
In Example 1, a liquid nutrient supplement composition was produced in the same manner as in Example 1 except that the vitamin-like substance was changed to inositol and the amount of the vitamin-like substance was changed to 1200 mg / 100 mL.

The obtained liquid nutrient supplement composition had a calorific value of 0.16 kcal / mL, a pH of 4.49, a viscosity of 22 mPa · s, a stability of ◎, a flavor of ◯, and an osmotic pressure of 376 mOsm / kg. It was. These results are shown in Table 9 below.

Claims (9)

A composition containing vitamins, trace minerals, and vitamin-like substances, 0.05 to 0.20% by mass (w / v) of agar having a jelly strength of 20 to 80 g / cm ² , and a thickening polysaccharide 0.1 to 0.3% by mass (w / v), calorie is 0.05 to 1.0 kcal / mL, pH is 3.0 to 4.5, viscosity is 10 to 30 mPa · s, osmotic pressure is A liquid nutrient supplement composition that is 250-350 mOsm / kg. 2. The composition according to claim 1, wherein 0.01 to 2000 mg of the vitamin, 0.1 μg to 55 mg of the trace mineral, and 10 mg to 1000 mg of the vitamin-like substance are contained per 100 mL of the liquid nutrient supplement composition. Liquid nutrient supplement composition. 3. The liquid nutrient supplement composition according to claim 1, comprising 0.1 to 500 μg of selenium as the trace mineral with respect to 100 mL of the liquid nutrient supplement composition. The liquid nutrient supplement composition according to any one of claims 1 to 3, comprising 10 to 1000 mg of carnitine as the vitamin-like substance with respect to 100 mL of the liquid nutrient supplement composition. The liquid nutrient supplement composition according to any one of claims 1 to 4, comprising 10 to 1000 mg of inositol as the vitamin-like substance with respect to 100 mL of the liquid nutrient supplement composition. The liquid nutrient supplement composition according to any one of claims 1 to 5, comprising 10 to 1000 mg of choline as the vitamin-like substance per 100 mL of the liquid nutrient supplement composition. For 100 mL of the liquid nutrient supplement composition, as the vitamin, 0.01 to 40 mg of vitamin B1, 0.01 to 20 mg of vitamin B2, 0.1 to 300 mg NE of niacin, 0.01 to 60 mg of vitamin B6, 0.01-100 μg of vitamin B12, 1-1000 μg of folic acid, 0.1-55 mg of pantothenic acid, 0.1-500 μg of biotin, 1-2000 mg of vitamin C, 0.1 to iron as the trace mineral, 2. 55 mg, 0.1-50 mg of zinc, 0.01-20 mg of copper, 0.01-15 mg of manganese, 0.1-3500 μg of iodine, 0.1-50 μg of chromium Liquid nutrition supplement composition in any one of -6. The liquid nutrient supplement composition according to any one of claims 1 to 7, wherein the polysaccharide thickener is carrageenan, gellan gum, or guar gum. The liquid nutrient replenishment composition according to any one of claims 1 to 8, which is sterilized in advance.