WO2013181755A1 - Human tissue kallikrein 1 glycosylation isoforms - Google Patents
Human tissue kallikrein 1 glycosylation isoforms Download PDFInfo
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- WO2013181755A1 WO2013181755A1 PCT/CA2013/050425 CA2013050425W WO2013181755A1 WO 2013181755 A1 WO2013181755 A1 WO 2013181755A1 CA 2013050425 W CA2013050425 W CA 2013050425W WO 2013181755 A1 WO2013181755 A1 WO 2013181755A1
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- CSUNLSYSEQIDMO-UHFFFAOYSA-N tiprenolol Chemical compound CSC1=CC=CC=C1OCC(O)CNC(C)C CSUNLSYSEQIDMO-UHFFFAOYSA-N 0.000 description 1
- 229950004988 tiprenolol Drugs 0.000 description 1
- 229950003004 tolamolol Drugs 0.000 description 1
- 229960002277 tolazamide Drugs 0.000 description 1
- OUDSBRTVNLOZBN-UHFFFAOYSA-N tolazamide Chemical compound C1=CC(C)=CC=C1S(=O)(=O)NC(=O)NN1CCCCCC1 OUDSBRTVNLOZBN-UHFFFAOYSA-N 0.000 description 1
- 229960002312 tolazoline Drugs 0.000 description 1
- JIVZKJJQOZQXQB-UHFFFAOYSA-N tolazoline Chemical compound C=1C=CC=CC=1CC1=NCCN1 JIVZKJJQOZQXQB-UHFFFAOYSA-N 0.000 description 1
- 229950000245 toliprolol Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000002103 transcriptional effect Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- NFACJZMKEDPNKN-UHFFFAOYSA-N trichlorfon Chemical compound COP(=O)(OC)C(O)C(Cl)(Cl)Cl NFACJZMKEDPNKN-UHFFFAOYSA-N 0.000 description 1
- 229960001641 troglitazone Drugs 0.000 description 1
- GXPHKUHSUJUWKP-UHFFFAOYSA-N troglitazone Chemical compound C1CC=2C(C)=C(O)C(C)=C(C)C=2OC1(C)COC(C=C1)=CC=C1CC1SC(=O)NC1=O GXPHKUHSUJUWKP-UHFFFAOYSA-N 0.000 description 1
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 230000001810 trypsinlike Effects 0.000 description 1
- 238000011664 type 2 diabetes animal model Methods 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 241001515965 unidentified phage Species 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 229960002381 vardenafil Drugs 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000011534 wash buffer Substances 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 229960000317 yohimbine Drugs 0.000 description 1
- BLGXFZZNTVWLAY-SCYLSFHTSA-N yohimbine Chemical compound C1=CC=C2C(CCN3C[C@@H]4CC[C@H](O)[C@@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 0.000 description 1
- AADVZSXPNRLYLV-UHFFFAOYSA-N yohimbine carboxylic acid Natural products C1=CC=C2C(CCN3CC4CCC(C(C4CC33)C(O)=O)O)=C3NC2=C1 AADVZSXPNRLYLV-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4853—Kallikrein (3.4.21.34 or 3.4.21.35)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21035—Tissue kallikrein (3.4.21.35)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
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CA2880085A CA2880085C (en) | 2012-06-04 | 2013-06-04 | Human tissue kallikrein 1 glycosylation isoforms |
ES13801165.5T ES2625548T3 (es) | 2012-06-04 | 2013-06-04 | Isoformas de glicosilación de la calicreína-1 tisular humana |
LTEP13801165.5T LT2854841T (lt) | 2012-06-04 | 2013-06-04 | Kalikreino 1 iš žmogaus audinio glikozilinimo izoformos |
EP13801165.5A EP2854841B1 (en) | 2012-06-04 | 2013-06-04 | Human tissue kallikrein 1 glycosylation isoforms |
DK13801165.5T DK2854841T3 (en) | 2012-06-04 | 2013-06-04 | Kallikrein-1-glycosylation isoforms of human tissue |
SI201330639A SI2854841T1 (sl) | 2012-06-04 | 2013-06-04 | Glikozilacijske izooblike humanega tkivnega kalikreina-1 |
CY20171100479T CY1119073T1 (el) | 2012-06-04 | 2017-05-03 | Ισομορφες γλυκοζυλιωσης ανθρωπινης ιστικης καλλικρεινης 1 |
HRP20170673TT HRP20170673T1 (hr) | 2012-06-04 | 2017-05-04 | Glikozilacijske izoforme kalikreina 1 iz ljudskog tkiva |
Applications Claiming Priority (4)
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US201261655388P | 2012-06-04 | 2012-06-04 | |
US61/655,388 | 2012-06-04 | ||
US201361789978P | 2013-03-15 | 2013-03-15 | |
US61/789,978 | 2013-03-15 |
Publications (1)
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WO2013181755A1 true WO2013181755A1 (en) | 2013-12-12 |
Family
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Family Applications (1)
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PCT/CA2013/050425 WO2013181755A1 (en) | 2012-06-04 | 2013-06-04 | Human tissue kallikrein 1 glycosylation isoforms |
Country Status (13)
Country | Link |
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US (3) | US20130323222A1 (sl) |
EP (1) | EP2854841B1 (sl) |
CA (1) | CA2880085C (sl) |
CY (1) | CY1119073T1 (sl) |
DK (1) | DK2854841T3 (sl) |
ES (1) | ES2625548T3 (sl) |
HR (1) | HRP20170673T1 (sl) |
HU (1) | HUE032613T2 (sl) |
LT (1) | LT2854841T (sl) |
PL (1) | PL2854841T3 (sl) |
PT (1) | PT2854841T (sl) |
SI (1) | SI2854841T1 (sl) |
WO (1) | WO2013181755A1 (sl) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9364521B2 (en) | 2012-06-04 | 2016-06-14 | Diamedica Inc. | Human tissue kallikrein 1 glycosylation isoforms |
US9616015B2 (en) | 2012-05-25 | 2017-04-11 | Diamedica Inc. | Formulations of human tissue kallikrein-1 for parenteral delivery and related methods |
US11857608B2 (en) | 2017-03-09 | 2024-01-02 | Diamedica Inc. | Dosage forms of tissue kallikrein 1 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN116135973A (zh) * | 2021-11-16 | 2023-05-19 | 江苏众红生物工程创药研究院有限公司 | 低糖基化修饰的激肽原酶及其聚乙二醇修饰物和应用 |
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EP0297913B1 (en) * | 1987-06-30 | 1995-02-15 | Amgen Inc. | Production of Kallikrein |
CA2659012A1 (en) * | 2006-07-26 | 2008-01-31 | Diamedica Inc. | Methods of diagnosis and treatment for metabolic disorders |
WO2012154574A1 (en) * | 2011-05-06 | 2012-11-15 | Diamedica Inc. | Compositions and methods for treating diabetes |
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
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US9616015B2 (en) | 2012-05-25 | 2017-04-11 | Diamedica Inc. | Formulations of human tissue kallikrein-1 for parenteral delivery and related methods |
US9364521B2 (en) | 2012-06-04 | 2016-06-14 | Diamedica Inc. | Human tissue kallikrein 1 glycosylation isoforms |
US9839678B2 (en) | 2012-06-04 | 2017-12-12 | Diamedica Inc. | Human tissue kallikrein 1 glycosylation isoforms |
US11857608B2 (en) | 2017-03-09 | 2024-01-02 | Diamedica Inc. | Dosage forms of tissue kallikrein 1 |
Also Published As
Publication number | Publication date |
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HRP20170673T1 (hr) | 2017-07-14 |
US20130323222A1 (en) | 2013-12-05 |
US9364521B2 (en) | 2016-06-14 |
US20170119862A1 (en) | 2017-05-04 |
EP2854841A4 (en) | 2016-03-09 |
US9839678B2 (en) | 2017-12-12 |
US20150196624A1 (en) | 2015-07-16 |
CA2880085C (en) | 2021-09-07 |
DK2854841T3 (en) | 2017-05-22 |
CY1119073T1 (el) | 2018-01-10 |
SI2854841T1 (sl) | 2017-06-30 |
LT2854841T (lt) | 2017-06-12 |
EP2854841B1 (en) | 2017-02-22 |
CA2880085A1 (en) | 2013-12-12 |
PT2854841T (pt) | 2017-05-15 |
EP2854841A1 (en) | 2015-04-08 |
ES2625548T3 (es) | 2017-07-19 |
HUE032613T2 (en) | 2017-10-30 |
PL2854841T3 (pl) | 2017-08-31 |
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