WO2013180127A1 - 近赤外蛍光を発する医療品、および医療品の使用状況確認装置 - Google Patents
近赤外蛍光を発する医療品、および医療品の使用状況確認装置 Download PDFInfo
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- WO2013180127A1 WO2013180127A1 PCT/JP2013/064764 JP2013064764W WO2013180127A1 WO 2013180127 A1 WO2013180127 A1 WO 2013180127A1 JP 2013064764 W JP2013064764 W JP 2013064764W WO 2013180127 A1 WO2013180127 A1 WO 2013180127A1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/06—Devices, other than using radiation, for detecting or locating foreign bodies ; determining position of probes within or on the body of the patient
- A61B5/061—Determining position of a probe within the body employing means separate from the probe, e.g. sensing internal probe position employing impedance electrodes on the surface of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/0208—Subcutaneous access sites for injecting or removing fluids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06066—Needles, e.g. needle tip configurations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/04—Surgical instruments, devices or methods, e.g. tourniquets for suturing wounds; Holders or packages for needles or suture materials
- A61B17/06—Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials
- A61B17/06166—Sutures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/08—Accessories or related features not otherwise provided for
- A61B2090/0807—Indication means
- A61B2090/0809—Indication of cracks or breakages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
- A61B2090/3937—Visible markers
- A61B2090/3941—Photoluminescent markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
- A61B90/90—Identification means for patients or instruments, e.g. tags
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M2039/0036—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use characterised by a septum having particular features, e.g. having venting channels or being made from antimicrobial or self-lubricating elastomer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/0208—Subcutaneous access sites for injecting or removing fluids
- A61M2039/0238—Subcutaneous access sites for injecting or removing fluids having means for locating the implanted device to insure proper injection, e.g. radio-emitter, protuberances, radio-opaque markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
- A61M39/02—Access sites
- A61M39/0208—Subcutaneous access sites for injecting or removing fluids
- A61M2039/0244—Subcutaneous access sites for injecting or removing fluids having means for detecting an inserted needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/33—Controlling, regulating or measuring
- A61M2205/3306—Optical measuring means
- A61M2205/3313—Optical measuring means used specific wavelengths
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/60—General characteristics of the apparatus with identification means
- A61M2205/6063—Optical identification systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/06—Illumination; Optics
- G01N2201/062—LED's
Definitions
- the present invention relates to a medical product that emits near-infrared fluorescence, and a use status confirmation device for the medical product.
- a septum into which an injection needle is inserted is used as a component of a subcutaneously implantable port embedded under the skin in order to inject a drug into a blood vessel or a sealed container containing an infusion preparation or the like.
- the septum is formed of silicone rubber, and is attached to a port housing or the like so as to receive a compressive force in order to enhance sealing performance.
- a part of the septum may be scraped off by the heel portion of the injection needle.
- the scraped piece is referred to as a “core”, and the phenomenon in which a core is generated by the puncture of an injection needle is referred to as “coring”.
- coring the phenomenon in which a core is generated by the puncture of an injection needle
- Patent Document 1 an RFID (Radio Frequency IDentification) tag is attached to a medical product, the medical product is scanned after surgery, the information recorded on the RFID tag is read, and the type and position of the medical product are read. A technique for confirming the above is disclosed.
- Patent Document 2 a technique of coating a fluorescent material for the purpose of labeling or for the purpose of improving visibility is known (see Patent Document 2).
- Patent Document 3 a technique for visualizing blood vessels by applying the principle that near infrared rays pass through the skin and is absorbed by red blood cell hemoglobin is known (see Patent Document 3).
- JP 2006-122321 A Special table 2008-515586 International Publication No. 2009/154081
- Patent Document 1 the technique described in Patent Document 1 is intended to prevent the medical product from being left behind by confirming the current position of the medical product, and it is impossible to confirm the damage of the medical product in the first place.
- the medical product to be confirmed is limited to a medical product having a size capable of attaching an RFID tag.
- Patent Document 3 the implant is coated with a fluorescent material in order to easily identify the implant.
- the fluorescence used is fluorescence that can be visually recognized, that is, visible light fluorescence.
- Patent Document 3 does not disclose a technique using near-infrared fluorescence.
- Patent Document 4 a blood vessel is visualized by a near-infrared camera having a near-infrared light source in order to output a positional relationship between a needle of a syringe needle and a blood vessel, which is a medical product, to a monitor as a planar image.
- a near-infrared camera having a near-infrared light source
- Patent Document 4 does not disclose a technique for visualizing an injection needle inserted subcutaneously.
- the present invention relates to a state of damage to a medical product in a situation where a medical product is used such that a part of the constituent members of the medical product becomes a separated piece when it is broken, or a relatively small medical device such as a suture needle or a suture thread. It is an object of the present invention to provide a medical product that emits near-infrared fluorescence and a medical product usage status confirmation device that can reliably check the usage status of a medical product, such as the presence or absence of the product.
- the medical product that emits near-infrared fluorescence according to the present invention includes at least one component capable of emitting light that includes a luminescent agent that emits near-infrared fluorescence when irradiated with excitation light. . Even when a part of the structural member is separated from the structural member as a separated piece due to breakage, the luminescent agent is also contained on the surface of the separated piece.
- the medical product emitting near-infrared fluorescence of the present invention is a medical product capable of emitting light that includes a light-emitting agent that emits near-infrared fluorescence when irradiated with excitation light.
- the medical product use status confirmation device of the present invention includes at least one component capable of emitting light including a luminescent agent that emits near-infrared fluorescence when irradiated with excitation light.
- An illumination unit that includes a light source that emits excitation light that excites a luminescent agent, and that emits excitation light emitted from the light source toward a medical product;
- An optical filter that blocks excitation light and transmits near-infrared fluorescence emitted by a luminescent agent;
- An imaging unit that receives near-infrared fluorescence transmitted through the optical filter;
- a display unit that displays an image captured by the imaging unit. The display unit displays an image based on the near-infrared fluorescence of the component member, and displays an image based on the near-infrared fluorescence of the
- the medical product use status confirmation device of the present invention includes a luminescent agent that emits near-infrared fluorescence when irradiated with excitation light, and capable of emitting light,
- An irradiation unit that irradiates excitation light emitted from the light source toward a surgical field for confirming the presence or absence of the medical product, comprising a light source that emits excitation light that excites the luminescent agent;
- An optical filter that blocks excitation light and transmits near-infrared fluorescence emitted by the luminescent agent;
- An imaging unit that receives near-infrared fluorescence transmitted through the optical filter;
- a display unit that displays an image captured by the imaging unit. When the medical product is present in the surgical field, an image based on near-infrared fluorescence of the medical product is displayed on the display unit.
- a medical product that emits near-infrared fluorescence includes at least one component capable of emitting light including a light-emitting agent that emits near-infrared fluorescence when irradiated with excitation light. Even when a part of the structural member is separated from the structural member as a separated piece due to breakage, the luminescent agent is also contained on the surface of the separated piece. Therefore, the position of the component member in the medical product can be accurately and easily confirmed by applying the medical product usage status confirmation device. Furthermore, it is possible to accurately and easily confirm that the component member is damaged or the state of the damage, and it is possible to take appropriate measures according to the use state of the medical product.
- Medical products that emit near-infrared fluorescence include a light-emitting suture needle, a light-emitting suture thread, and a light-emitting cloth-like consumable that contains a light-emitting agent that emits near-infrared fluorescence when irradiated with excitation light. Or a non-woven consumable that can emit light. Therefore, the presence / absence of a medical product can be confirmed by applying the medical product usage status confirmation device. When an image based on near-infrared fluorescence appears on the display unit, the user can accurately and easily confirm that medical products are present in the surgical field and where they are present, and remove the medical products. It is possible to take appropriate measures according to the use status of medical products such as.
- an image based on the near-infrared fluorescence of the component member is displayed on the display unit, and when the component member is damaged, an image based on the near-infrared fluorescence of the separation piece is displayed. Displayed on the display. Therefore, the position of the component member in the medical product can be confirmed accurately and easily. Furthermore, it is possible to accurately and easily confirm that the component member is damaged or the state of the damage, and it is possible to take appropriate measures according to the use state of the medical product.
- the medical product usage confirmation device when there is a medical product in the operative field, an image based on the near-infrared fluorescence of the medical product is displayed on the display unit. Therefore, it is possible to accurately and easily confirm that medical products are present in the operative field and where they are present, and take appropriate measures according to the usage status of the medical products such as removing the medical products. It becomes possible. Furthermore, since presence / absence is confirmed based on near-infrared fluorescence, there is no limitation on the size of a medical product to be confirmed.
- FIG. 6A is a diagram illustrating a situation in which a medical product emits near-infrared fluorescence when the medical product is not implanted subcutaneously.
- FIG. 6A illustrates a case where excitation light is off, and
- FIG. It is a figure which shows when light is on.
- FIG. 7A is a diagram illustrating a situation in which a medical product emits near-infrared fluorescence when the medical product is implanted subcutaneously.
- FIG. 7A illustrates a case where excitation light is off
- FIG. 7B illustrates excitation light. It is a figure which shows when is turned on. It is explanatory drawing which shows the use condition confirmation apparatus of the medical product which concerns on 3rd Embodiment. It is a schematic block diagram which shows the structure of the medical condition use condition confirmation apparatus which concerns on 4th Embodiment. It is a figure which shows the cloth-like expendable material as a medical article.
- FIG. 1 is an explanatory view showing a medical product use status confirmation apparatus 10 according to the first embodiment
- FIG. 2 is a perspective view showing a subcutaneously implantable port 81 shown in FIG.
- a medical product 80 that emits near-infrared fluorescence whose usage is to be confirmed, is configured to emit light that includes a light-emitting agent that emits near-infrared fluorescence when irradiated with excitation light on the surface.
- At least one member 83 is provided. Even when a part of the constituent member 83 is broken and separated from the constituent member 83 as the separating piece 83a, the luminescent agent is also included on the surface of the separating piece 83a.
- the medical product use status confirmation apparatus 10 includes the medical product 80 that emits near-infrared fluorescence and a light source 32 that emits excitation light that excites a luminescent agent.
- the irradiation unit 30 that irradiates the excitation light emitted from the light source 32, the optical filter 40 that blocks the excitation light and transmits the near-infrared fluorescence emitted by the luminescent agent, and the near-infrared fluorescence that has passed through the optical filter 40.
- a monitor 60 (corresponding to a display unit) for displaying an image photographed by the camera 50.
- an image based on near-infrared fluorescence of the component member 83 is displayed on the monitor 60, and when the component member 83 is damaged, the image of the separation piece 83a is displayed.
- An image based on infrared fluorescence is displayed on the monitor 60. Details will be described below.
- the medical product 80 shown in FIG. 1 is a subcutaneously implantable port 81 that is implanted under the skin 20 in order to inject a drug into a blood vessel.
- the subcutaneous implantable port 81 is used for patients who repeat infusion and the like.
- the subcutaneous implantable port 81 includes a housing 82 that forms an injection chamber 82 a, a septum 83 that is attached to the top of the housing 82, and a catheter 84 that is attached to the housing 82. ing.
- One end of the catheter 84 communicates with the liquid injection chamber 82 a and the other end is inserted into the blood vessel 21.
- the septum 83 is attached to the housing 82 so as to receive a compressive force in order to enhance the sealing performance.
- the septum 83 is inserted with an injection needle 90 such as a Hoover needle.
- the component capable of emitting light is at least the septum 83. This is because it is possible to confirm the state of damage such as coring as the use state of the medical product 80 so that the core 83a does not enter the blood vessel 21 together with the medicine. Furthermore, because the septum 83 emits near-infrared fluorescence, the site where the subcutaneous implantable port 81 is embedded and the position to be punctured can be accurately confirmed.
- the housing 82 may be allowed to emit light, or part or all of the catheter 84 may be allowed to emit light.
- the septum 83 as a constituent member is formed of a material in which a luminescent agent is applied to the surface or a luminescent agent is kneaded.
- the septum 83 itself can emit light. Furthermore, when a part of the septum 83 is broken and the core 83a is generated, the light emitting agent is included in the surface of the core 83a, and the core 83a also emits light. Can do.
- the septum 83 in the illustrated example is formed of silicone rubber kneaded with a luminescent agent.
- the luminescent agent is a drug that can be used on the human body or animal, and any appropriate material can be used as long as it emits near-infrared fluorescence when irradiated with excitation light.
- the excitation wavelength is a wavelength region suitable for causing the luminescent agent to emit light, and is preferably a wavelength region of near-infrared light, and those having a wavelength region of 600 nm to 1400 nm can be used.
- Near-infrared light is highly permeable to human tissues such as skin, fat, and muscle, and can be transmitted up to about 5 mm to 20 mm below the surface of a living tissue.
- the excitation light can be transmitted to the position where the septum 83 is embedded, and the septum 83 and the core 83a caused by the damage can be emitted.
- the luminescent agent is disclosed in indocyanine green (ICG) that emits near-infrared fluorescence when irradiated with excitation light, or Japanese Patent Application No. 2010-23479 (Japanese Patent Laid-Open No. 2011-162445) by the present applicant.
- ICG indocyanine green
- Such an azo-boron complex compound can be used.
- Indocyanine green is a dye that is excited by absorbing near-infrared excitation light in the wavelength region of about 800 nm and emits near-infrared fluorescence at about 850 nm.
- An azo-boron complex compound is a compound that improves light absorption characteristics and light emission characteristics by forming a hydrazone compound into a boron complex and emits strong near-infrared fluorescence.
- the azo-boron complex compound can be easily dispersed in a polymer resin, and when a fluorescent film is produced by dispersing in an resin, excellent light absorption characteristics and light emission characteristics are obtained as in the case of the compound alone. Demonstrate.
- An example of the light absorption characteristic and the light emission characteristic of the azo-boron complex compound is as follows. In the case of the compound alone, the absorption maximum wavelength is 674 nm, and the fluorescence maximum wavelength is 743 nm (Example 1 (2 in Table 1 in the publication). )), When a fluorescent film is prepared, the absorption maximum wavelength is 662 nm and the fluorescence maximum wavelength is 702 nm (see the row of Example 1 (2) in Table 2 in the publication).
- the irradiation unit 30 includes a chassis 31 and a light source 32 that is disposed in the chassis 31 and emits excitation light that excites the luminescent agent.
- the chassis 31 is formed of a metal material such as aluminum that does not transmit excitation light. Excitation light emitted from the light source 32 is irradiated toward the subcutaneous implantable port 81 embedded in the living body.
- the light source 32 for example, an LED that emits near-infrared excitation light in a wavelength range of 600 nm to 1400 nm can be used.
- the optical filter 40 can be inserted between the imaging element in the camera 50 and the lens, or can be disposed in front of the camera 50.
- the optical filter 40 preferably sets the transmittance for visible light to be lower than the transmittance for near-infrared fluorescence. This is because a weak near-infrared fluorescent image can be clearly displayed on a visible light image.
- a near-infrared CCD camera, a CMOS camera, or the like that captures near-infrared fluorescence transmitted through the optical filter 40 is applied.
- the CCD camera is a camera composed of a Charge Coupled Device element
- the CMOS camera is a camera using a complementary metal oxide semiconductor.
- Data captured by a near-infrared CCD camera or the like is subjected to image processing and image analysis such as noise processing, edge processing, and contrast enhancement, and converted into image data to be displayed on the monitor 60.
- the camera 50 can pick up an image of the entire septum 83 by receiving near-infrared fluorescence emitted by the luminescent agent of the septum 83 with a light receiving element. Near-infrared fluorescence emitted by the luminescent agent of the septum 83 passes through the living tissue, and this is received by the camera 50 to photograph the septum 83. The camera 50 also captures the outline of the human body at the same time.
- the imaging by the camera 50 may be monochrome or color.
- the camera 50 may be one in which the light source 32 is annularly provided around the lens. Thereby, it becomes possible to photograph the medical product 80 more appropriately.
- the monitor 60 is not particularly limited as long as an image captured by the camera 50 can be displayed.
- a desktop display or a head-mounted display may be used.
- the displayed image may be either monochrome or color.
- On the monitor 60 an image based on the near infrared fluorescence of the septum 83 is displayed.
- an image based on the near infrared fluorescence of the core 83a is displayed. The user looks at the image displayed on the monitor 60 and confirms the position of the septum 83 in the subcutaneous implantable port 81, the occurrence of damage to the septum 83, and the state of the damage.
- a subcutaneously implantable port 81 including a septum 83 capable of emitting light is previously implanted in a patient's body.
- the irradiation unit 30 When injecting a drug into the blood vessel 21 via the subcutaneous implantable port 81, the irradiation unit 30 irradiates near infrared excitation light emitted from the light source 32 toward the subcutaneous implantable port 81.
- the septum 83 When the near infrared excitation light passes through the living body and is irradiated to the septum 83, the septum 83 emits near infrared fluorescence.
- indocyanine green is used as the luminescent agent, the luminescent agent is excited by absorbing near-infrared excitation light in the wavelength region of about 800 nm and emits near-infrared fluorescence at about 850 nm.
- Near infrared fluorescence emitted from the septum 83 passes through the optical filter 40 and is received by the camera 50, and an image based on the near infrared fluorescence of the septum 83 is displayed on the monitor 60.
- reflected light reflected from the surface of the living body is also received by the camera 50, whereby a contour image of the living body is displayed on the monitor 60 together with the septum 83.
- the user can accurately and easily confirm the position of the septum 83 in the subcutaneous implantable port 81 by looking at the image displayed on the monitor 60. Since the position of the septum 83 is a position where the injection needle 90 is punctured, the user can confirm the puncture position accurately and easily.
- the near-infrared excitation light is irradiated toward the subcutaneous implantable port 81.
- a part of the septum 83 may be scraped off by the heel portion of the injection needle 90 to generate the core 83a. Since the light-emitting agent is included in the surface of the core 83a, when coring occurs, the core 83a emits near-infrared fluorescence when near-infrared excitation light is irradiated onto the core 83a.
- Near-infrared fluorescence emitted from the core 83a passes through the optical filter 40, is received by the camera 50, and an image based on the near-infrared fluorescence of the core 83a is displayed on the monitor 60.
- the user can accurately and easily confirm that the septum 83 is damaged and the state of the damage by looking at the image displayed on the monitor 60.
- the core 83a can be prevented from entering the blood vessel 21 together with the drug.
- the medical product usage status confirmation device 10 does not use X-rays to confirm the usage status of the medical product 80, the problem that the operator and the patient are exposed to X-rays does not fundamentally occur. In addition, even the resin or rubber medical product 80 that transmits X-rays can be used.
- the subcutaneously implantable port 81 that emits near-infrared fluorescence according to the first embodiment has a light-emitting septum 83 that includes a light-emitting agent that emits near-infrared fluorescence when irradiated with excitation light. It has. Even when part of the septum 83 is separated from the septum 83 as the core 83a due to breakage, the luminescent agent is also included on the surface of the core 83a. Therefore, the position of the septum 83 and the puncture position in the subcutaneous implantable port 81 can be confirmed accurately and easily by applying the medical product use status confirmation device 10 of the present embodiment. Furthermore, it is possible to accurately and easily confirm that the septum 83 is damaged or the state of the damage, and it is possible to take appropriate measures according to the use state of the medical product 80.
- the septum 83 is formed of a material in which a luminescent agent is applied to the surface or a luminescent agent is kneaded, the septum 83 itself can emit light, and further, a part of the septum 83 is damaged.
- a luminescent agent is included in the surface of the core 83a, and the core 83a can also emit light by being irradiated with excitation light.
- an image based on the near-infrared fluorescence of the septum 83 is displayed on the monitor 60, and when the septum 83 is damaged, the core 83a An image based on near-infrared fluorescence is displayed on the monitor 60. Therefore, the position of the septum 83 and the puncture position in the subcutaneous implantable port 81 can be confirmed accurately and easily. Furthermore, it is possible to accurately and easily confirm that the septum 83 is damaged or the state of the damage, and it is possible to take appropriate measures according to the use state of the medical product 80.
- FIG. 3 is a schematic block diagram showing the configuration of the medical product usage status confirmation apparatus 11 according to the second embodiment. Members common to those in the first embodiment are denoted by the same reference numerals, and description thereof is partially omitted.
- the medical product usage status confirmation device 11 includes a subcutaneously implantable port 81 that emits near-infrared fluorescence, an irradiation unit 30, an optical filter 40, and a camera. 50 and a monitor 60, and an image based on the near-infrared fluorescence of the septum 83 is displayed on the monitor 60, and when the septum 83 is damaged, an image based on the near-infrared fluorescence of the core 83a Is displayed on the monitor 60.
- the medical product use status confirmation device 11 further includes a first light emitting region and a second light emitting region having a smaller area than the first light emitting region in an image based on near-infrared fluorescence.
- a controller 70 (corresponding to a control unit) for notifying that the septum 83 is damaged is detected.
- the size of the core 83a generated by the coring is very small compared to the size of the septum 83. For this reason, the area of the image based on the near-infrared fluorescence of the core 83a is very small compared to the area of the image based on the near-infrared fluorescence of the septum 83. Therefore, when the first light-emitting region and the second light-emitting region having a smaller area than the first light-emitting region exist in the image based on near-infrared fluorescence, it is determined that the core 83a is generated by coring. can do.
- the first light emitting region is a region based on near infrared fluorescence of the septum 83
- the second light emitting region is a region based on near infrared fluorescence of the core 83a.
- the controller 70 performs image processing and image analysis on the image data based on near-infrared fluorescence, extracts a light emitting area, and calculates the area of each light emitting area when a plurality of light emitting areas are detected.
- the controller 70 identifies the light emitting region with the larger area as the first light emitting region, and identifies the light emitting region with the smaller area as the second light emitting region.
- the controller 70 determines that the septum 83 is damaged when the area of the second light emitting region is equal to or less than a preset threshold value (for example, several percent) with respect to the area of the first light emitting region. To do. Then, the controller 70 notifies the user that the septum 83 has been damaged. The notification is performed by displaying on the monitor 60 or generating a warning sound.
- the first light emitting region and the second light emitting region having a smaller area than the first light emitting region are detected in the image based on near infrared fluorescence. Since the controller 70 for notifying that the septum 83 is damaged in the case of failure is further provided, in addition to the effects of the first embodiment, the fact that the septum 83 is damaged and the situation of the damage are further increased. It can be confirmed accurately and easily, and an appropriate measure according to the use state of the medical product 80 can be taken more quickly.
- the medical product 80 shown in FIG. 4 is a sealed container 85 in which an infusion preparation or the like is placed.
- a sealed container 85 also has a septum 86 through which the injection needle 91 is inserted as a constituent member. Coring can also occur in the septum 86. Therefore, it is preferable that the septum 86 in the sealed container 85 is also formed by applying a light emitting agent on the surface or a material in which the light emitting agent is kneaded. This is because when a part of the septum 86 is broken and the core 86a is generated, the luminescent agent is included in the surface of the core 86a, and the core 86a can emit light.
- a medical product 80 shown in FIG. 5 is an indwelling needle 87 for placing a needle tip in a blood vessel, and is used, for example, when performing external circulation in artificial dialysis or infusion into a blood vessel by infusion.
- the indwelling needle 87 has a hard inner needle 88 and a soft outer needle 89 through which the inner needle 88 is inserted.
- the tip of the inner needle 88 protrudes from the tip of the outer needle 89 and punctures, but a part of the soft outer needle 89 may be scraped off by the tip of the inner needle 88.
- a soft outer needle 89 as a constituent member is configured to emit light.
- the soft outer needle 89 includes a luminescent agent that emits near-infrared fluorescence when irradiated with excitation light.
- the surface containing the luminescent agent is preferably both the inner surface on which the hard inner needle 88 slides and the outer surface. Even when a part of the outer needle 89 is separated from the outer needle 89 as a separation piece 89a due to breakage, the luminescent agent is also included on the surface of the separation piece 89a.
- the outer needle 89 is preferably formed by applying a light-emitting agent on the surface or a material in which the light-emitting agent is kneaded. This is because, when a part of the outer needle 89 is broken and the separation piece 89a is generated, the luminescent agent is included in the surface of the separation piece 89a, and the separation piece 89a can emit light.
- the soft outer needle 89 in the indwelling needle 87 punctured into the blood vessel is applied. It is possible to accurately and easily confirm that the damage has occurred and the state of the damage, and it is possible to take an appropriate measure according to the use state of the medical product 80.
- the present invention is not limited to the above-described medical product 80 (81, 85, 87), and may be damaged, and can be widely applied to the medical product 80 whose usage is to be confirmed.
- the medical product 80 includes at least one component capable of emitting light including a luminescent agent that emits near-infrared fluorescence when irradiated with excitation light, and a part of the component is broken as a separation piece. Even when separated from the constituent members, the luminescent agent may be contained on the surface of the separation piece.
- FIG. 6 is a diagram illustrating a situation in which the medical product emits near-infrared fluorescence when the medical product is not implanted subcutaneously.
- FIG. 6A illustrates a case where the excitation light is off
- FIG. B is a diagram showing when the excitation light is on.
- FIG. 7 is a diagram illustrating a situation where the medical product emits near-infrared fluorescence when the medical product is implanted subcutaneously
- FIG. 7A illustrates a case where the excitation light is off.
- (B) is a figure which shows when excitation light is on.
- the tube 101 on the left side of the two tubes 101 and 102 is a soft outer needle that is a constituent member of a generally used indwelling needle for veins.
- the tube 102 on the right side in the drawing is a near-infrared fluorescent tube capable of emitting light containing a luminescent agent that emits near-infrared fluorescence when irradiated with excitation light.
- the luminescent agent the azo-boron complex compound of Example 1 in the above-mentioned publication (Japanese Patent Laid-Open No. 2011-162445) was used.
- the near-infrared fluorescent tube 102 on the right side in the figure emits near-infrared fluorescence when irradiated with excitation light, and an image based on near-infrared fluorescence. Is clearly displayed on the monitor.
- FIG. 7 shows an example in which a medical component is damaged under the skin.
- the fragment 103 of the near-infrared fluorescent tube 102 was embedded under the skin of the mouse. 7A and 7B, as is clear from the irradiation with excitation light, the fragment 103 of the near-infrared fluorescent tube 102 existing under the skin emits near-infrared fluorescence, and the fragment 103 An image based on near-infrared fluorescence was clearly displayed on the monitor. Therefore, it was found that the state of breakage of the components of the medical product can be easily confirmed percutaneously as the use state of the medical product.
- FIG. 8 is an explanatory view showing a medical product usage status confirmation apparatus 110 according to the third embodiment.
- medical product 180 that emits near-infrared fluorescence which is a target for confirmation of existence, includes a luminescent agent that emits near-infrared fluorescence when irradiated with excitation light.
- the medical product usage status confirmation apparatus 110 includes the medical product 180 that emits near-infrared fluorescence and a light source 132 that emits excitation light that excites a luminescent agent.
- An irradiation unit 130 that irradiates excitation light emitted from the light source 132 toward the surgical field 120 for confirming the presence / absence, an optical filter 140 that blocks the excitation light and transmits near-infrared fluorescence emitted by the luminescent agent, and an optical filter And a camera 150 (corresponding to an imaging unit) that receives near-infrared fluorescence that has passed through 140, and a monitor 160 (corresponding to a display unit) that displays an image captured by the camera 150.
- a monitor 160 corresponding to a display unit
- a medical product 180 shown in FIG. 8 is a luminescent suture needle 181 having a luminescent agent applied on the surface thereof, and a suture 185 fixed to the suture needle 181.
- the suture thread 185 is formed from a synthetic thread obtained by kneading a luminescent agent with a resin material.
- the suture needle 181 has a body 182 having a predetermined cross-sectional shape, and a taper 184 that tapers from the body 182 toward the sharp needle tip 183.
- a blind hole is formed in the base end portion of the body portion 182.
- stainless steel or the like is used as the base material of the suture needle 181.
- a suture needle 181 capable of emitting light is formed by applying a light emitting agent to the surface of the base material to form a thin light emitting layer.
- a luminescent agent may be applied to a part of the surface of the substrate so that only part of the suture needle 181 can emit light.
- the suture thread 185 is made of a synthetic thread such as nylon, polydioxanone, or polyglycolic acid, in which a luminescent agent is kneaded with a resin material.
- the suture 185 may be a knitting yarn or a monofilament.
- the distal end of the suture thread 185 is inserted into the blind hole of the suture needle 181. By caulking the proximal end portion of the body portion 182, the suture thread 185 is fixed to the proximal end portion of the suture needle 181.
- the luminescent agent is a drug that can be used on the human body or animal, and an appropriate material can be used as long as it emits near-infrared fluorescence when irradiated with excitation light.
- the excitation wavelength is a wavelength region suitable for causing the luminescent agent to emit light, and is preferably a wavelength region of near-infrared light, and those having a wavelength region of 600 nm to 1400 nm can be used.
- Near-infrared light is highly permeable to human tissues such as skin, fat, and muscle, and can be transmitted up to about 5 mm to 20 mm below the surface of a living tissue. Therefore, even when the medical product 180 capable of emitting light exists in the living body, the medical product 180 can be emitted by transmitting the excitation light to that position.
- the luminescent agent is indocyanine green (ICG) that emits near-infrared fluorescence when irradiated with excitation light, or Japanese Patent Application No. 2010-23479 (Japanese Unexamined Patent Application Publication No. An azo-boron complex compound disclosed in JP 2011-162445 A) can be used.
- ICG indocyanine green
- JP 2011-162445 A Japanese Patent Application No. 2010-23479
- the irradiation unit 130 includes a chassis 131 and a light source 132 that emits excitation light that is disposed in the chassis 131 and excites the luminescent agent.
- the chassis 131 is made of a metal material such as aluminum that does not transmit excitation light.
- Excitation light emitted from the light source 132 is irradiated toward the surgical field 120 for confirming the presence or absence of the medical product 180.
- the surgical field 120 includes not only a living body but also all the places where the medical product 180 can exist, such as on a bed or a floor surface in an operating room.
- As the light source 132 for example, an LED that emits near-infrared excitation light in a wavelength range of 600 nm to 1400 nm can be used.
- Each of the optical filter 140, the camera 150, and the monitor 160 has the same configuration as the optical filter 40, the camera 50, and the monitor 60 in the first embodiment.
- the camera 150 can take an image of the suture needle 181 and the suture thread 185 by receiving near-infrared fluorescence emitted by the light emitting agent of the suture needle 181 and the suture thread 185 with a light receiving element. Even when the suture needle 181 and the suture thread 185 are present in the living body, near-infrared fluorescence emitted from the luminescent agent of the suture needle 181 and the suture thread 185 is transmitted through the living tissue, and this is received by the camera 150 and sutured. The needle 181 and the suture 185 are photographed. The camera 150 also captures the outline of the human body at the same time.
- the imaging by the camera 150 may be monochrome or color.
- the camera 150 may be one in which the light source 132 is annularly provided around the lens. As a result, the surgical field 120 can be imaged more appropriately.
- the monitor 160 is not particularly limited as long as an image captured by the camera 150 can be displayed.
- a desktop display or a head-mounted display may be used.
- the displayed image may be either monochrome or color.
- the suture needle 181 to which the suture 185 is fixed is present in the surgical field 120.
- the irradiation unit 130 When confirming whether or not the medical product 180 exists in the surgical field 120, the irradiation unit 130 irradiates the surgical field 120 with near-infrared excitation light emitted from the light source 132. At this time, the user moves the irradiation unit 130 to scan the operative field 120 over a wide range. When the near-infrared excitation light is irradiated to the suture needle 181 and the suture thread 185 during scanning, the luminescent agents on the surfaces of the suture needle 181 and the suture thread 185 are excited to emit near-infrared fluorescence.
- the luminescent agent When indocyanine green is used as the luminescent agent, the luminescent agent is excited by absorbing near-infrared excitation light in the wavelength region of about 800 nm and emits near-infrared fluorescence at about 850 nm.
- Near-infrared fluorescence emitted from the suture needle 181 and the suture thread 185 is transmitted through the optical filter 140 and received by the camera 150, and an image based on the near-infrared fluorescence of the suture needle 181 and suture thread 185 is displayed on the monitor 160.
- the In addition, reflected light reflected from the surface of the living body is also received by the camera 150, so that a contour image of the living body is also displayed on the monitor 160 together with the suture needle 181 and the suture thread 185.
- the appearance of an image based on near-infrared fluorescence on the monitor 160 allows the user to accurately and easily confirm that the suture needle 181 and suture 185 are present in the surgical field 120 and where they are present. it can.
- the medical product use status confirmation device 110 does not use X-rays to confirm the presence or absence of the medical product 180, the problem that the operator and the patient are exposed to X-rays does not fundamentally occur. In addition, the presence or absence of a medical product 180 made of resin or rubber that transmits X-rays can be confirmed.
- the medical product 180 that emits near-infrared fluorescence is a medical product capable of emitting light that includes a luminescent agent that emits near-infrared fluorescence when irradiated with excitation light.
- the user can accurately and easily confirm that the suture needle 181 and the suture thread 185 are present in the operative field 120 and where they are present. Therefore, it is possible to take appropriate measures according to the use situation of the medical product such as removing the suture needle 181 and the suture thread 185.
- the medical product use status confirmation device 110 of the first embodiment when the suture needle 181 and the suture thread 185 are present in the surgical field 120, the near-infrared fluorescence of the suture needle 181 and the suture thread 185 is increased. The based image is displayed on the monitor 160. Therefore, it is possible to accurately and easily confirm that the suture needle 181 and the suture thread 185 are present in the operative field 120 and the position where the suture needle 181 and the suture thread 185 are present, and use of a medical product such as removing the suture needle 181 and the suture thread 185 is used. Appropriate measures can be taken according to the situation. Furthermore, since presence / absence is confirmed based on near-infrared fluorescence, there is no restriction on the size of the medical product 180 to be confirmed.
- FIG. 9 is a schematic block diagram showing a configuration of a medical product usage status confirmation apparatus 111 according to the fourth embodiment.
- the same reference numerals are given to members common to the third embodiment, and a part of the description is omitted.
- the medical product usage status confirmation device 111 includes a suture needle 181 and a suture 185 that emit near-infrared fluorescence, an irradiation unit 130, an optical filter 140, and the like.
- a suture needle 181 and the suture thread 185 that emit near-infrared fluorescence
- an irradiation unit 130 that emit near-infrared fluorescence
- an optical filter 140 that filters the suture needle 181 and the suture thread 185 that emit near-infrared fluorescence
- an image based on the near-infrared fluorescence of the suture needle 181 and the suture thread 185 is displayed on the monitor 160. Is displayed.
- the suture needle 181 and the suture thread 185 are present in the surgical field 120.
- a controller 170 corresponding to a control unit.
- the controller 170 performs image processing and image analysis on the image data based on near-infrared fluorescence, extracts a light emitting area, and when the light emitting area cannot be extracted, the suture needle 181 and the suture thread in the operative field 120. It is determined that 185 does not exist. On the other hand, when the light emitting area can be extracted, the controller 170 determines that the suture needle 181 and the suture thread 185 exist in the operative field 120. Then, the controller 170 notifies the user that the suture needle 181 and the suture thread 185 are damaged in the surgical field 120. The notification is performed by displaying on the monitor 160 or generating a warning sound.
- a controller that notifies that the suture needle 181 and the suture thread 185 exist in the surgical field 120 when an image based on near-infrared fluorescence is detected. 170, the presence of the suture needle 181 and the suture 185 in the surgical field 120 and the position where they are present can be more accurately and easily confirmed. Appropriate measures can be taken more quickly according to the usage status of the medical product such as removal.
- a form of the medical product 180 that emits near-infrared fluorescence a form in which a suture needle 181 capable of emitting light and a general suture thread that does not emit light are connected in advance, a general suture needle that does not emit light, and a suture thread 185 capable of emitting light. And may be connected in advance. Alternatively, the light emitting suture needle 181 and the light emitting suture thread 185 may be separated.
- the medical product 180 is not limited to the suture needle 181 and the suture thread 185, and can be applied to, for example, a medical product 180 as shown in FIG.
- a medical product 180 shown in FIG. 10 is a light-emitting cloth-like consumable 186 in which a synthetic thread 189 obtained by kneading a luminescent agent with a resin material is woven.
- the cloth consumable 186 is, for example, a medical gauze 186.
- the illustrated gauze 186 is composed of a plurality of warp yarns 187 and weft yarns 188, which are plain woven so as to alternately intersect at substantially equal intervals.
- a synthetic yarn 189 in which a luminescent agent is kneaded with a resin material is woven as one of the constituent yarns.
- thermoplastic resin such as a silicon-based resin, a polyvinyl chloride resin, a polypropylene resin, a polyester resin, or a polyethylene resin
- a plurality of synthetic yarns 189 may be woven.
- the form of weaving is not limited to a plain weave, and a form such as a twill weave may be used.
- the presence or absence of the gauze 186 can be confirmed by applying the above-described medical use condition confirmation devices 110 and 111.
- the synthetic thread 189 emits light and an image based on near-infrared fluorescence appears on the monitor 160, the user can accurately and easily confirm that the gauze 186 is present in the operative field 120 and the position where the gauze 186 is present. It is possible to take appropriate measures according to the use situation of the medical product such as removing the gauze 186. In particular, since it is difficult to visually check cloth consumables such as gauze 186 when blood is absorbed, it is advantageous to apply the medical-use condition checking devices 110 and 111.
- the medical article 180 may be a non-woven consumable that can emit light, in addition to the cloth-like consumable 186, without including the synthetic yarn 189.
- the non-woven consumable is, for example, medical absorbent cotton.
- Absorbent cotton includes one or a plurality of synthetic yarns 189 obtained by kneading a luminescent agent with a resin material without weaving.
- the presence or absence of absorbent cotton can be confirmed by applying the above-described medical use condition confirmation devices 110 and 111.
- the synthetic yarn 189 emits light and an image based on near-infrared fluorescence appears on the monitor 160, the user should accurately and easily confirm that the absorbent cotton is present in the surgical field 120 and the position where the absorbent cotton is present. It is possible to take appropriate measures according to the use situation of medical products such as removing absorbent cotton. In particular, since non-woven consumables such as absorbent cotton are difficult to visually confirm when they absorb blood, it is advantageous to apply the medical product usage confirmation devices 110 and 111.
- the consumable containing at least one synthetic yarn 189 has been described.
- the cloth-like consumable 186 and the non-woven-like consumable using only the synthetic yarn 189 obtained by kneading the light emitting agent with the resin material. Consumables may be formed.
- the medical product 180 may be any medical product capable of emitting light that includes a luminescent agent that emits near-infrared fluorescence when irradiated with excitation light. Therefore, by applying a luminescent agent to various medical products such as scissors, tweezers, catheters, injection needles, tubes, etc., or by forming these medical products from a material in which the luminescent agent is incorporated, It is possible to confirm the presence or absence of the medical device as the usage status of the medical product.
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Abstract
Description
発光剤を励起させる励起光を出射する光源を備え、医療品に向けて光源から出射された励起光を照射する照射部と、
励起光を遮断するとともに発光剤が発する近赤外蛍光を透過させる光学フィルターと、
光学フィルターを透過した近赤外蛍光を受光する撮像部と、
撮像部によって撮影した画像を表示する表示部と、を有している。表示部には、構成部材の近赤外蛍光に基づく画像が表示されるとともに、構成部材に破損が生じた場合に分離片の近赤外蛍光に基づく画像が表示される。
前記発光剤を励起させる励起光を出射する光源を備え、前記医療品の存否を確認する術野に向けて前記光源から出射された励起光を照射する照射部と、
励起光を遮断するとともに前記発光剤が発する近赤外蛍光を透過させる光学フィルターと、
前記光学フィルターを透過した近赤外蛍光を受光する撮像部と、
前記撮像部によって撮影した画像を表示する表示部と、を有している。前記術野内に前記医療品が存在する場合には、前記医療品の近赤外蛍光に基づく画像が前記表示部に表示される。
図1は、第1の実施形態に係る医療品の使用状況確認装置10を示す説明図、図2は、図1に示される皮下埋め込み型ポート81を示す斜視図である。
図3は、第2の実施形態に係る医療品の使用状況確認装置11の構成を示す概略ブロック図である。第1の実施形態と共通する部材には同一の符号を付し、その説明は一部省略する。
近赤外蛍光を発する医療品80として、皮下埋め込み型ポート81のセプタム83を発光可能に構成した第1と第2の実施形態について説明したが、本発明はこの場合に限定されるものではなく、例えば図4、図5に示すような医療品80にも適用可能である。
励起光が照射されることによって、医療品が近赤外蛍光を発する状況について説明する。図6は、医療品が皮下に埋め込まれていない場合において、医療品が近赤外蛍光を発する状況を示す図であり、図6(A)は励起光がオフのときを示し、図6(B)は励起光がオンのときを示す図である。また、図7は、医療品が皮下に埋め込まれた場合において、医療品が近赤外蛍光を発する状況を示す図であり、図7(A)は励起光がオフのときを示し、図7(B)は励起光がオンのときを示す図である。
図8は、第3の実施形態に係る医療品の使用状況確認装置110を示す説明図である。
図9は、第4の実施形態に係る医療品の使用状況確認装置111の構成を示す概略ブロック図である。第3の実施形態と共通する部材には同一の符号を付し、その説明は一部省略する。
近赤外蛍光を発する医療品180の形態としては、発光可能な縫合針181と発光しない一般的な縫合糸とが予め接続された形態、発光しない一般的な縫合針と発光可能な縫合糸185とが予め接続された形態でもよい。また、発光可能な縫合針181と、発光可能な縫合糸185とが分離している形態でもよい。
20 皮膚、
21 血管、
30 照射部、
32 光源、
40 光学フィルター、
50 カメラ(撮像部)、
60 モニター(表示部)、
70 コントローラー(制御部)、
80 近赤外蛍光を発する医療品、
81 皮下埋め込み型ポート(医療品)、
82 ハウジング、
83 セプタム(構成部材)、
83a コア(分離片)、
84 カテーテル、
85 密封容器(医療品)、
86 セプタム(構成部材)、
86a コア(分離片)、
87 留置針(医療品)、
88 硬質の内針、
89 軟質の外針(構成部材)、
89a 分離片、
90、91 針、
110、111 医療品の使用状況確認装置、
120 術野、
130 照射部、
132 光源、
140 光学フィルター、
150 カメラ(撮像部)、
160 モニター(表示部)、
170 コントローラー(制御部)、
180 近赤外蛍光を発する医療品、
181 縫合針(医療品)、
185 縫合糸(医療品)、
186 ガーゼ、布状消耗品(医療品)、
189 発光剤を樹脂素材に混練した合成糸。
Claims (11)
- 励起光が照射されることによって近赤外蛍光を発する発光剤を表面に含む発光可能な構成部材を少なくとも1つ備え、前記構成部材における一部が破損にともなって分離片として前記構成部材から分離された場合にも前記発光剤が前記分離片の表面にも含まれてなる、近赤外蛍光を発する医療品。
- 前記構成部材は、皮下埋め込み型ポートや密封容器において用いられ針が挿通されるセプタム、または、留置針における硬質の内針が挿通される軟質の外針である、請求項1に記載の近赤外蛍光を発する医療品。
- 前記構成部材は、前記発光剤が表面に塗布され、または前記発光剤が練り込まれた材料から形成されてなる、請求項1または請求項2に記載の近赤外蛍光を発する医療品。
- 励起光が照射されることによって近赤外蛍光を発する発光剤を表面に含む発光可能な構成部材を少なくとも1つ備え、前記構成部材における一部が破損にともなって分離片として前記構成部材から分離された場合にも前記発光剤が前記分離片の表面にも含まれる医療品と、
前記発光剤を励起させる励起光を出射する光源を備え、前記医療品に向けて前記光源から出射された励起光を照射する照射部と、
励起光を遮断するとともに前記発光剤が発する近赤外蛍光を透過させる光学フィルターと、
前記光学フィルターを透過した近赤外蛍光を受光する撮像部と、
前記撮像部によって撮影した画像を表示する表示部と、を有し、
前記構成部材の近赤外蛍光に基づく画像が前記表示部に表示されるとともに、前記構成部材に破損が生じた場合に前記分離片の近赤外蛍光に基づく画像が前記表示部に表示されてなる、医療品の使用状況確認装置。 - 近赤外蛍光に基づく画像において第1の発光領域と前記第1の発光領域よりも面積が小さい第2の発光領域とを検出した場合に、前記構成部材に破損が生じたことを報知する制御部をさらに有する、請求項4に記載の医療品の使用状況確認装置。
- 前記構成部材は、皮下埋め込み型ポートや密封容器において用いられ針が挿通されるセプタム、または、留置針における硬質の内針が挿通される軟質の外針である、請求項4または請求項5に記載の医療品の使用状況確認装置。
- 前記構成部材は、前記発光剤が表面に塗布され、または前記発光剤が練り込まれた材料から形成されてなる、請求項4~請求項6のいずれか1つに記載の医療品の使用状況確認装置。
- 励起光が照射されることによって近赤外蛍光を発する発光剤を表面に含む発光可能な医療品であって、 前記発光剤を表面に塗布した発光可能な縫合針、前記発光剤を樹脂素材に混練した合成糸から形成した発光可能な縫合糸、前記合成糸を織り込んだ発光可能な布状消耗品、または前記合成糸を織り込むことなく含んだ発光可能な不織布状消耗品である、近赤外蛍光を発する医療品。
- 励起光が照射されることによって近赤外蛍光を発する発光剤を表面に含む発光可能な医療品と、
前記発光剤を励起させる励起光を出射する光源を備え、前記医療品の存否を確認する術野に向けて前記光源から出射された励起光を照射する照射部と、
励起光を遮断するとともに前記発光剤が発する近赤外蛍光を透過させる光学フィルターと、
前記光学フィルターを透過した近赤外蛍光を受光する撮像部と、
前記撮像部によって撮影した画像を表示する表示部と、を有し、
前記術野内に前記医療品が存在する場合に、前記医療品の近赤外蛍光に基づく画像が前記表示部に表示されてなる、医療品の使用状況確認装置。 - 近赤外蛍光に基づく画像を検出した場合に、前記術野内に前記医療品が存在することを報知する制御部をさらに有する、請求項9に記載の医療品の使用状況確認装置。
- 前記医療品が、前記発光剤を表面に塗布した発光可能な縫合針、前記発光剤を樹脂素材に混練した合成糸から形成した発光可能な縫合糸、前記合成糸を織り込んだ発光可能な布状消耗品、または前記合成糸を織り込むことなく含んだ発光可能な不織布状消耗品である、請求項9または請求項10に記載の医療品の使用状況確認装置。
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US11179058B2 (en) | 2021-11-23 |
EP2856965A1 (en) | 2015-04-08 |
CA2874817C (en) | 2019-04-16 |
AU2013268518B2 (en) | 2017-06-15 |
EP2856965B1 (en) | 2020-04-01 |
US20220031188A1 (en) | 2022-02-03 |
AU2013268518A1 (en) | 2015-01-22 |
US20150148665A1 (en) | 2015-05-28 |
EP2856965A4 (en) | 2016-06-22 |
CA2874817A1 (en) | 2013-12-05 |
JPWO2013180127A1 (ja) | 2016-01-21 |
JP5958922B2 (ja) | 2016-08-02 |
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