WO2013043085A8 - Состав (rs)-2-(2-оксо-4-фенилпирролидин-1-ил)ацетамид, обладающий модуляторной активностью с соразмерным влиянием, фармацевтический состав субстанции (варианты) и его применение, композиция (варианты) - Google Patents

Состав (rs)-2-(2-оксо-4-фенилпирролидин-1-ил)ацетамид, обладающий модуляторной активностью с соразмерным влиянием, фармацевтический состав субстанции (варианты) и его применение, композиция (варианты) Download PDF

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Publication number
WO2013043085A8
WO2013043085A8 PCT/RU2012/000773 RU2012000773W WO2013043085A8 WO 2013043085 A8 WO2013043085 A8 WO 2013043085A8 RU 2012000773 W RU2012000773 W RU 2012000773W WO 2013043085 A8 WO2013043085 A8 WO 2013043085A8
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WIPO (PCT)
Prior art keywords
variants
phenylpyrrolidin
oxo
modulatory activity
composition
Prior art date
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PCT/RU2012/000773
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English (en)
French (fr)
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WO2013043085A1 (ru
Inventor
Валентина Ивановна АХАПКИНА
Роман Витальевич АХАПКИН
Original Assignee
Akhapkina Valentina Ivanovna
Akhapkin Roman Vitalyevich
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47914659&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2013043085(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to MD20140042A priority Critical patent/MD20140042A2/ru
Priority to MX2014003483A priority patent/MX2014003483A/es
Priority to CN201280057155.8A priority patent/CN103987386A/zh
Priority to BR112014006910A priority patent/BR112014006910A2/pt
Priority to EA201490615A priority patent/EA201490615A1/ru
Application filed by Akhapkina Valentina Ivanovna, Akhapkin Roman Vitalyevich filed Critical Akhapkina Valentina Ivanovna
Priority to US14/346,445 priority patent/US20140315972A1/en
Priority to CA 2849711 priority patent/CA2849711A1/en
Priority to UAA201403117A priority patent/UA111981C2/uk
Priority to EP12834473.6A priority patent/EP2762138A4/en
Priority to JP2014531758A priority patent/JP2014526551A/ja
Publication of WO2013043085A1 publication Critical patent/WO2013043085A1/ru
Publication of WO2013043085A8 publication Critical patent/WO2013043085A8/ru

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/16—Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using titration
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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Abstract

Изобретение относится к различным областям медицины, фармации и фармакологии, химико-фармацевтической, фармацевтической и парафармацевтической промышленности, конкретно касается нового класса средств, обладающих модуляторной активностью с соразмерным влиянием. Изобретение заключается в том, что предлагаемый продукт (RS)-2-(2-оксо-4-фенилпирролидин-1-ил)ацетамид не содержит в своем составе биологически инертных веществ, оказывающих негативное влияние на его впервые выявленные и существенно улучшенные известные свойства и характеристики, открывая при этом ранее не известные основополагающие и наиважнейшие представления о составе, расширяя области его применения с повышением эффективности и безопасности применения, увеличением терапевтической широты, обеспечивает получение продукта и его продукции с выявленными свойствами и характеристиками.
PCT/RU2012/000773 2011-09-22 2012-09-20 Фармацевтическая субстанция (варианты) и полученные на ее основе композиции, обладающие модуляторной активностью с соразмерным влиянием WO2013043085A1 (ru)

Priority Applications (10)

Application Number Priority Date Filing Date Title
JP2014531758A JP2014526551A (ja) 2011-09-22 2012-09-20 相応の作用を伴う調節活性を有している（ｒｓ）−２−（２−オキソ−４−フェニルピロリジン−１−イル）アセトアミド化合物、医薬物質（変種）およびその適用、それらの組成物（変形）
MX2014003483A MX2014003483A (es) 2011-09-22 2012-09-20 (rs) -2- (2-oxo-4-fenilpirrolidin-1-il)acetamida compuesto que tiene actividad moduladora con un efecto proporcionado, sustancia farmaceutica (variantes) y su aplicacion, y composicion (variantes) de la misma.
CN201280057155.8A CN103987386A (zh) 2011-09-22 2012-09-20 具有有相称效果的调节活性的(rs)-2-(2-氧代-4-苯基吡咯烷-1-基)乙酰胺化合物、药物物质(变体)及其应用、其组合物(变体)
BR112014006910A BR112014006910A2 (pt) 2011-09-22 2012-09-20 composto, substância farmacêutica do composto, método para produzir a substância farmacêutica, uso da substância farmacêutica, método de ensaio de titulação, e, composição farmacêutica e parafarmacêutica
EA201490615A EA201490615A1 (ru) 2011-09-22 2012-09-20 Состав (rs)-2-(2-оксо-4-фенилпирролидин-1-ил)ацетамид, обладающий модуляторной активностью с соразмерным влиянием, фармацевтический состав субстанции (варианты) и его применение, композиция (варианты)
MD20140042A MD20140042A2 (ru) 2011-09-22 2012-09-20 Соединение (RS)-2-(2-оксо-4-фенилпирролидин-1-ил)ацетамид обладающее модуляторной активностью с соразмерным влиянием, фармацевтический состав субстанции (варианты) и его применение, композиция (варианты)
US14/346,445 US20140315972A1 (en) 2011-09-22 2012-09-20 RS)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide compound having modulatory activity with a commensurate effect, pharmaceutical substance (variants) and its application, composition (variants) thereof
CA 2849711 CA2849711A1 (en) 2011-09-22 2012-09-20 (rs)-2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide compound having modulatory activity with a commensurate effect, pharmaceutical substance (variants) and its application, composition (variants) thereof
UAA201403117A UA111981C2 (uk) 2011-09-22 2012-09-20 Сполука (rs)-2-(2-оксо-4-фенілпіролідин-1-іл)ацетамід, яка має модуляторну активність з пропорційним впливом, фармацевтичний склад субстанції (варіанти) та його застосування, композиція (варіанти)
EP12834473.6A EP2762138A4 (en) 2011-09-22 2012-09-20 PHARMACEUTICAL ACTIVE SUBSTANCE (VARIANT) AND COMPOSITIONS BASED ON IT WITH MODULATING ACTIVITY WITH A CORRESPONDING EFFECT

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2011138840/15A RU2480214C1 (ru) 2011-09-22 2011-09-22 Состав, обладающий модуляторной активностью с соразмерным влиянием, фармацевтическая субстанция (варианты), применение фармацевтической субстанции, фармацевтическая и парафармацевтическая композиция (варианты), способ получения фармацевтических составов
RU2011138840 2011-09-22

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WO2013043085A1 WO2013043085A1 (ru) 2013-03-28
WO2013043085A8 true WO2013043085A8 (ru) 2013-10-31

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PCT/RU2012/000773 WO2013043085A1 (ru) 2011-09-22 2012-09-20 Фармацевтическая субстанция (варианты) и полученные на ее основе композиции, обладающие модуляторной активностью с соразмерным влиянием

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Country Link
US (1) US20140315972A1 (ru)
EP (1) EP2762138A4 (ru)
JP (1) JP2014526551A (ru)
CN (1) CN103987386A (ru)
BR (1) BR112014006910A2 (ru)
CA (1) CA2849711A1 (ru)
EA (1) EA201490615A1 (ru)
MD (1) MD20140042A2 (ru)
MX (1) MX2014003483A (ru)
RU (1) RU2480214C1 (ru)
UA (1) UA111981C2 (ru)
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EP2762138A4 (en) 2015-12-02
RU2480214C1 (ru) 2013-04-27
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MX2014003483A (es) 2014-11-10
JP2014526551A (ja) 2014-10-06
EP2762138A1 (en) 2014-08-06
CN103987386A (zh) 2014-08-13
US20140315972A1 (en) 2014-10-23
RU2011138840A (ru) 2013-03-27
UA111981C2 (uk) 2016-07-11
BR112014006910A2 (pt) 2017-04-11
CA2849711A1 (en) 2013-03-28
WO2013043085A1 (ru) 2013-03-28

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