WO2013031762A1 - 洗浄剤組成物 - Google Patents
洗浄剤組成物 Download PDFInfo
- Publication number
- WO2013031762A1 WO2013031762A1 PCT/JP2012/071682 JP2012071682W WO2013031762A1 WO 2013031762 A1 WO2013031762 A1 WO 2013031762A1 JP 2012071682 W JP2012071682 W JP 2012071682W WO 2013031762 A1 WO2013031762 A1 WO 2013031762A1
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- WIPO (PCT)
- Prior art keywords
- glycol
- acid
- poe
- ether
- cleaning composition
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/39—Derivatives containing from 2 to 10 oxyalkylene groups
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/896—Polysiloxanes containing atoms other than silicon, carbon, oxygen and hydrogen, e.g. dimethicone copolyol phosphate
- A61K8/898—Polysiloxanes containing atoms other than silicon, carbon, oxygen and hydrogen, e.g. dimethicone copolyol phosphate containing nitrogen, e.g. amodimethicone, trimethyl silyl amodimethicone or dimethicone propyl PG-betaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/88—Ampholytes; Electroneutral compounds
- C11D1/94—Mixtures with anionic, cationic or non-ionic compounds
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/48—Medical, disinfecting agents, disinfecting, antibacterial, germicidal or antimicrobial compositions
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- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/66—Non-ionic compounds
- C11D1/72—Ethers of polyoxyalkylene glycols
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D1/00—Detergent compositions based essentially on surface-active compounds; Use of these compounds as a detergent
- C11D1/88—Ampholytes; Electroneutral compounds
- C11D1/90—Betaines
Definitions
- the present invention relates to a cleaning composition, and in particular, to improvement of its antibacterial activity (bacteria and fungi).
- antibacterial ingredients formulated to prevent product deterioration in cosmetics
- a detergent composition such as shampoo
- antibacterial ingredients formulated to prevent product deterioration in cosmetics
- benzoic acid sodium benzoate, paraoxybenzoate (paraben), sorbic acid, dehydroacetic acid, phenoxyethanol, benzalkonium chloride, benzethonium chloride, chlorohexidine and the like.
- all of these ingredients are associated with problems of irritation to the skin and eyes and allergies, so the amount that can be formulated is limited, and it is difficult to provide sufficient antibacterial activity to the subject by using shampoo. .
- Patent Document 1 proposes antibacterial agents containing 1,2-alkanediol and imidazoline-type amphoteric surfactants.
- the cleaning composition having it has not been put into practical use yet.
- This invention is made
- the cleaning composition according to the present invention contains an imidazolinium betaine type amphoteric surfactant and 0.5 to 10% by mass of PEG-1 lauryl glycol represented by the following general formula (I). It is characterized by.
- the cleaning composition further includes a component having an antibacterial effect or a bactericidal effect selected from divalent glycol, hinokitiol, trichlorocarbanilide, and benzalkonium chloride.
- the cleaning composition is for animals.
- the said detergent composition is for patients with human atopic dermatitis.
- the cleaning composition according to the present invention contains an imidazolinium betaine-type amphoteric surfactant and PEG-1 lauryl glycol.
- Imidazolinium betaine-type amphoteric surfactant The imidazolinium betaine-type amphoteric surfactant that can be used in the present invention is not particularly limited as long as it is usually used in cosmetics and quasi drugs. What is represented by general formula (II) is mentioned.
- R 1 represents a linear or branched alkyl group, alkenyl group or acyl group having 8 to 18, preferably 10 to 14 carbon atoms.
- alkyl group include octyl group, nonyl group, decyl group, undecyl group, dodecyl group, tridecyl group, tetradecyl group, pentadecyl group, hexadecyl group, heptadecyl group, octadecyl group, 2-ethylhexyl group and the like.
- alkenyl group examples include octenyl group, nonenyl group, decenyl group, undecenyl group, dodecenyl group, tetradecenyl group, oleyl group and the like.
- alkenyl group examples include lauroyl group, myristoyl group, palmitoyl group, stearoyl group, oleoyl group, coconut oil fatty acid acyl group (cocoyl group) and the like.
- imidazolinium betaine type amphoteric surfactants include N-lauroyl-N′-carboxymethyl-N′-hydroxyethylethyleneimidazolinium betaine, N-cocoyl-N′-carboxymethyl-N ′. -Hydroxyethylethyleneimidazolinium betaine, 2-cocoyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, 2-lauryl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, 2-undecyl-N , N, N- (hydroxyethylcarboxymethyl) -2-imidazolinium betaine and the like.
- the imidazolinium betaine surfactant may be in the form of a salt represented by the following general formula (III).
- R 1 represents a linear or branched alkyl group, alkenyl group or acyl group having 8 to 18, preferably 10 to 14 carbon atoms, as in the general formula (II).
- M represents a counter ion (salt), and examples thereof include alkali metal ions such as sodium and potassium, alkaline earth metal ions such as magnesium and calcium, and amines such as ammonium, monoethanolamine, diethanolamine and triethanolamine. .
- imidazolinium betaine-type amphoteric surfactants include, for example, SOFTAZOLIN LHL, SOFTAZOLIN LHL-SF (manufactured by Kawaken Fine Chemical Co., Ltd.), OVAZOLIN 66N, OVAZOLIN 66N-SF (manufactured by Toho Chemical Co., Ltd.), NISSAN ANON GLM (Manufactured by NOF Corporation) and the like, and any of them can be suitably used.
- the imidazolinium betaine-type amphoteric surfactant can be used alone or in combination of two or more.
- the compounding amount of the imidazolinium betaine type amphoteric surfactant is 1.5 to 12% by mass, preferably 3 to 9% by mass as a pure component with respect to the detergent composition. If the blending amount of the components is less than 1.5% by mass as a pure component, not only the cleaning effect as a cleaning composition but also antibacterial activity may be insufficient. Moreover, even if it mixes exceeding 12 mass%, the antibacterial activity according to the compounding quantity will not be obtained.
- mold amphoteric surfactant is normally provided in the form of the aqueous solution of this component.
- the imidazolinium betaine type amphoteric surfactant may be used so that the pure amount is within the above-mentioned blending amount range.
- the blending amount in the composition of the present invention is 5 to 40% by mass, preferably 10 to 30% by mass.
- PEG-1 lauryl glycol PEG-1 lauryl glycol used in the present invention is a kind of alkanediol type nonionic surfactant and is a compound represented by the following general formula (I).
- m and n represent the addition mole number of an oxyethylene group, respectively, and the average of m + n is 1.
- New Pole DDE-10 manufactured by Sanyo Chemical Industries
- the blending amount of the PEG-1 lauryl glycol is 0.5 to 10% by mass, preferably 1 to 7% by mass, based on the detergent composition. If the amount of the component is less than 0.5% by mass, the antibacterial and antifungal properties may be insufficient. Moreover, even if it mixes exceeding 10 mass%, the antibacterial activity according to the compounding quantity will not be obtained.
- PEG-1 lauryl glycol Since PEG-1 lauryl glycol has a strong interaction with cells, it approaches the cells and takes water from fungi and molds in order to dissolve the components themselves, thereby making their growth impossible. From this, it was known that PEG-1 lauryl glycol has antibacterial activity, but when the component is used in combination with an imidazolinium betaine type amphoteric surfactant, the antibacterial activity of the resulting composition is It became clear for the first time by the present application that it significantly increased beyond the level predicted from the amount of ingredients.
- imidazolinium betaine type amphoteric surfactant itself has antibacterial activity, its effect is not sufficient by itself, so the improvement of the antibacterial activity (bacteria and fungi) in the composition is a two-component It is considered that the imidazolinium betaine-type amphoteric surfactant acts not only on the gradual effect but also promotes the ability of PEG-1 lauryl glycol and exhibits a synergistic effect.
- the cleaning composition of the present invention has high antibacterial activity against bacteria and fungi. Therefore, the present invention is expected to be effective in preventing infection by preventing the growth of bacteria and fungi adhering to the hair and skin by daily use like a normal cleaning composition.
- the detergent composition of the present invention can widely sterilize bacteria and fungi related to infectious diseases of animals including humans, and in particular, Escelichia coli (E.
- Staphylococcus intermedius (causative agent of pyoderma), Staphylococcus aureus (skin epidermis), Methicillin-resistant Staphylococcus aureus (multidrug-resistant bacterium), Staphylococcus epidermidis (skin epidermis), Pseudomonas aeruginosa (Pseudomonas aeruginosa), Pasteurella multocida (Animal Pasteurellosis), Proteus bacteria such as mirabilis (causative agent of urinary tract infection); and Malassezia pachydermatis (causative agent of otitis externa), Microsporum canis (causative agent of ringworm), Trichophyton It is effective for sterilization of microorganisms found in pet animals such as dogs and cats such as mentagrophytes (causal agents of ringworm) and fungi such as Candida.
- the imidazolinium betaine-type amphoteric surfactant is suitable for the cleaning composition of the present invention as a cleaning component because it is highly safe to living organisms and very low in eye irritation.
- the cleaning composition of the present invention is particularly effective for use in human atopic dermatitis patients.
- the component which has a bactericidal effect or a bactericidal effect individually or in combination from a viewpoint which raises the antimicrobial activity of a cleaning composition more.
- the component having a bactericidal effect that can be used in the present invention is a component that is usually used in cosmetics and quasi-drugs, and does not impair the safety of the composition according to the present invention, or does not impair the safety.
- the amount is not particularly limited, but in particular, 1,3-butylene glycol, 1,4-butylene glycol, 2,3-butylene glycol, 2,3-dimethyl-2,3-butylene glycol, 1,3-propane
- examples thereof include components such as diol, propylene glycol (1,2-propanediol), divalent glycol such as dipropylene glycol and ethylene glycol, hinokitiol, trichlorocarbanilide (TCC), and benzalkonium chloride.
- Preferred divalent glycols are 1,3-propanediol, propylene glycol, and 1,3-butylene glycol.
- TCC trichlorocarbanilide
- a compound selected from acyl taurine salts, acylmethyl taurate salts, and acyl glutamate salts is particularly preferable as an anionic surfactant serving as a cleaning component.
- the acyl taurine salt include coconut oil fatty acid (cocoyl) taurine salt, lauroyl taurine salt, myristoyl taurine salt, palmitoyl taurine salt, stearoyl taurine salt and the like.
- acylmethyl taurine salt examples include coconut oil fatty acid (cocoyl) methyl taurine salt, lauroyl methyl taurine salt, myristoyl methyl taurine salt, palmitoyl methyl taurine salt, stearoyl methyl taurine salt and the like.
- acyl glutamate examples include coconut oil fatty acid (cocoyl) glutamate, lauroyl glutamate, myristoyl glutamate, palmitoyl glutamate, stearoyl glutamate, and the like.
- sodium salt, potassium salt, magnesium salt, a triethanolamine salt etc. are mentioned, for example.
- anionic surfactants preferably lauroyl methyl taurate, coconut oil fatty acid (cocoyl) methyl taurate, lauroyl glutamate, and / or coconut oil fatty acid (cocoyl) glutamate,
- the ion is sodium or potassium.
- the anionic surfactant is suitable as a cleaning component of the present invention because it has extremely high safety to living organisms, and the antibacterial activity of the present invention does not decrease due to its formulation.
- the compounding amount of the component may be an amount usually used in a cleaning composition, and is preferably in a range of 1.5 to 7.5% by mass as a pure component. When the amount is less than 1.5% by mass, the cleaning effect and foaming may be insufficient. When the amount exceeds 7.5% by mass, the hair is squeezed when dried after using the cleaning composition. May occur.
- the commercial raw material of the said anionic surfactant may be provided in the form of the aqueous solution of this component.
- the pure component of the anionic surfactant may be adjusted so as to fall within the above-mentioned blending amount range.
- the blending amount in the composition of the present invention is 5 to 25% by mass.
- the cleaning composition according to the present invention can be blended with the following components that are usually used in cleaning compositions for cosmetics and quasi-drugs as long as the effects of the present invention are not impaired.
- the cleaning composition of the present invention is prepared by a conventional method by appropriately blending the above-mentioned preferred components and / or the following components into the imidazolinium betaine amphoteric surfactant and PEG-1 lauryl glycol, which are the essential components. Can do.
- humectant examples include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate Sodium lactate, bile salt, dl-pyrrolidone carboxylate, short-chain soluble collagen, diglycerin (EO) PO adduct, Izayoi rose extract, yarrow extract, merirot extract and the like.
- EO diglycerin
- Examples of the color material include red 201, red 202, red 204, red 205, red 220, red 226, red 228, red 405, orange 203, orange 204, and yellow 205. , Yellow 401, and Blue 404, Red 3, Red 104, Red 106, Red 227, Red 230, Red 401, Red 505, Orange 205, Yellow 4, Yellow 5, Examples thereof include organic pigments such as yellow 202, yellow 203, green 3 and blue 1, and natural pigments such as chlorophyll and ⁇ -carotene.
- liquid oils examples include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, southern castor oil, castor oil, linseed oil , Safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, cinnagiri oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin and the like.
- higher alcohols examples include linear alcohols (eg, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol); branched chain alcohols (eg, stearyl glycerine ether (batyl alcohol)) 2-decyltetradecinol, lanolin alcohol, cholesterol, phytosterol, hexyl decanol, isostearyl alcohol, octyldodecanol, etc.).
- linear alcohols eg, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol
- branched chain alcohols eg, stearyl glycerine ether (batyl alcohol)
- 2-decyltetradecinol lanolin alcohol
- cholesterol phytosterol
- hexyl decanol isostearyl
- Ester oils include isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyl decyl dimethyloctanoate, cetyl lactate, myristyl lactate, Lanolin acetate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, monoisostearic acid-N-alkyl glycol, neopentyl glycol dicaprate, apple Acid diisostearyl, di-2-heptylundecanoic acid glycerin, tri-2-ethylhexanoi
- silicone oil examples include linear polysiloxanes (for example, dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane, etc.); cyclic polysiloxanes (for example, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexyl). Silicone resin, silicone rubber, various modified polysiloxanes (amino-modified polysiloxane, polyether-modified polysiloxane, alkyl-modified polysiloxane, fluorine-modified polysiloxane, etc.); acrylic silicone And the like.
- linear polysiloxanes for example, dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane, etc.
- cyclic polysiloxanes for example, octamethylcyclot
- natural water-soluble polymers include plant-based polymers (for example, gum arabic, tragacanth gum, galactan, guar gum, carob gum, caraya gum, carrageenan, pectin, agar, quince seed (malmello), alge colloid (guckweed extract), starch (Rice, corn, potato, wheat, etc.); microbial polymers (eg, xanthan gum, dextran, succinoglucan, pullulan, etc.); animal polymers (eg, collagen, casein, albumin, gelatin, etc.) .
- plant-based polymers for example, gum arabic, tragacanth gum, galactan, guar gum, carob gum, caraya gum, carrageenan, pectin, agar, quince seed (malmello), alge colloid (guckweed extract), starch (Rice, corn, potato, wheat, etc.
- microbial polymers eg, xanthan gum, dextran, succino
- Semi-synthetic water-soluble polymers include, for example, starch polymers (eg, carboxymethyl starch, methylhydroxypropyl starch, etc.); cellulose polymers (methylcellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate) , Hydroxypropylcellulose, carboxymethylcellulose, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder, etc.); alginic acid polymers (eg, sodium alginate, propylene glycol alginate, etc.); cationized cellulose; cationized guar gum; cationized starch; Fenucreek gum and the like.
- starch polymers eg, carboxymethyl starch, methylhydroxypropyl starch, etc.
- cellulose polymers methylcellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate
- Hydroxypropylcellulose carboxy
- Synthetic water-soluble polymers include, for example, vinyl polymers (eg, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, carboxyvinyl polymer); polyoxyethylene polymers (eg, polyethylene glycol 20,000, 40).
- Acrylic polymer eg, sodium polyacrylate, polyethyl acrylate, polyacrylamide, etc.
- polyethyleneimine polyquaternium 51; polyquaternium-6; polyquaternium-7; polyquaternium-22; polyquaternium- 39; polyquaternium-47; polyquaternium-53 and the like.
- thickener other than the water-soluble polymer examples include dextrin, sodium pectate, locust bean gum, tamarint gum, dialkyldimethylammonium sulfate cellulose, aluminum magnesium silicate, bentonite, hectorite, laponite, and silicic anhydride. Can be mentioned.
- ultraviolet absorber examples include benzoic acid-based ultraviolet absorbers (for example, paraaminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester.
- PABA paraaminobenzoic acid
- PABA monoglycerin ester N, N-dipropoxy PABA ethyl ester
- N, N-diethoxy PABA ethyl ester examples include benzoic acid-based ultraviolet absorbers (for example, paraaminobenzoic acid (hereinafter abbreviated as PABA), PABA monoglycerin ester, N, N-dipropoxy PABA ethyl ester, N, N-diethoxy PABA ethyl ester.
- PABA paraaminobenzoic acid
- lower alcohols examples include ethanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol and the like.
- polyhydric alcohol examples include ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, tetramethylene glycol, 2,3-butylene glycol, pentamethylene glycol, and 2-butene.
- Examples of monosaccharides include D-glyceryl aldehyde, dihydroxyacetone, D-erythrose, D-erythrulose, D-threose, erythritol, L-arabinose, D-xylose, L-lyxose, D-arabinose, D-ribose, D Ribulose, D-xylulose, L-xylulose, D-glucose, D-talose, D-psicose, D-galactose, D-fructose, L-galactose, L-mannose, D-tagatose, heptose, octulose, 2-deoxy -D-ribose, 6-deoxy-L-galactose, 6-deoxy-L-mannose, D-glucosamine, D-galactosamine, sialic acid, aminouronic acid, muramic acid, D-glucuronic acid, D-mann
- oligosaccharide examples include sucrose, guanthianose, umbelliferose, lactose, planteose, isoliquinoses, ⁇ , ⁇ -trehalose, raffinose, lycnose, umbilicin, stachyose, and verbosecose saccharides.
- amino acids include neutral amino acids (eg, threonine, cysteine, etc.); basic amino acids (eg, hydroxylysine, etc.) and the like.
- amino acid derivatives examples include acyl sarcosine sodium (lauroyl sarcosine sodium), acyl glutamate, acyl ⁇ -alanine sodium, glutathione, pyrrolidone carboxylic acid and the like.
- Examples of the sequestering agent include 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium, edetate disodium, edetate trisodium, edetate tetrasodium, Examples include sodium citrate, sodium polyphosphate, sodium metaphosphate, gluconic acid, malic acid, citric acid, ascorbic acid, succinic acid, edetic acid, trisodium ethylenediaminehydroxyethyl triacetate, tetrasodium etidronate, and the like.
- antioxidants examples include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, kephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.
- the anionic surfactant include fatty acid soaps (for example, atrium laurate, sodium palmitate, etc.); higher alkyl sulfates (for example, sodium lauryl sulfate, potassium lauryl sulfate, etc.); alkyl ether sulfates ( For example, POE lauryl sulfate triethanolamine, etc .; Phosphate ester salt (POE oleyl ether sodium phosphate, POE stearyl ether phosphate, etc.); Sulfosuccinate (eg, sodium di-2-ethylhexyl sulfosuccinate, monolauroyl monoethanol) Sodium amidopolyoxyethylene sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate,
- lipophilic nonionic surfactant examples include sorbitan fatty acid esters (for example, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate).
- sorbitan fatty acid esters for example, sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate.
- Sorbitan trioleate diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate); glycerin polyglycerin fatty acids (eg mono cottonseed oil fatty acid glycerin, glyceryl monoerucate, glycerin sesquioleate, mono Glyceryl stearate, ⁇ , ⁇ '-oleic acid pyroglutamate glycerin, monostearate glycerin malate, etc.); propylene glycol fatty acid esters (eg For example, propylene glycol monostearate); hardened castor oil derivative; glycerin alkyl ether and the like.
- glycerin polyglycerin fatty acids eg mono cottonseed oil fatty acid glycerin, glyceryl monoerucate, glycerin sesquioleate, mono Gly
- hydrophilic nonionic surfactant examples include POE sorbitan fatty acid esters (for example, POE sorbitan monooleate, POE sorbitan monostearate, POE sorbitan monooleate, POE sorbitan tetraoleate, etc.); POE sorbite fatty acid Esters (eg, POE sorbite monolaurate, POE sorbite monooleate, POE sorbite pentaoleate, POE sorbite monostearate, etc.); POE glycerin fatty acid esters (eg, POE glycerin monostearate, POE glycerin monoisostearate) Rate, POE glycerin triisostearate, etc.); POE fatty acid esters (for example, POE distearate, POE monodiolate, ethylene glycol distearate) POE alkyl ethers (for example, POE lauryl ether
- amphoteric surfactants include amidopropyl betaines (for example, coconut oil fatty acid amidopropyl betaine, lauric acid amidopropyl betaine, myristic acid amidopropyl betaine, palm kernel oil fatty acid amidopropyl betaine); amidosulfobetaines ( Lauric acid amidopropyl hydroxysulfobetaine etc.); amidoamine oxides (lauric acid amidopropyl dimethylamine oxide etc.); carbobetaines (eg hydroxyalkyl (C12-14) hydroxyethylmethylglycine etc.).
- amidopropyl betaines for example, coconut oil fatty acid amidopropyl betaine, lauric acid amidopropyl betaine, myristic acid amidopropyl betaine, palm kernel oil fatty acid amidopropyl betaine
- amidosulfobetaines Lauric acid amidopropyl hydroxysulfobetaine etc.
- amidoamine oxides lauric acid
- preservatives ethyl paraben, butyl paraben, etc.
- whitening agents eg, vitamin C derivatives, yukinoshita extract, arbutin, etc.
- blood circulation promoters nicotinic acid, benzyl nicotinate, Nicotinic acid tocopherol, nicotinic acid ⁇ -butoxy ester, minoxidil or its analog, vitamin E, ⁇ -oryzanol, alkoxycarbonylpyridine N-oxide, carpronium chloride, acetylcholine or a derivative thereof, etc .
- various extracts for example, ginger , Oats, Auren, Shikon, Birch, Loquat, Carrot, Aloe, Zeniaoi, Iris, Grape, Loofah, Lily, Saffron, Senkyu, Pepper, Hypericum, Onionis, Garlic, Pepper, Chimpi, Toki, Button, Seaweed,
- the cleaning composition according to the present invention can be used for cleaning the hair of animals such as dogs and cats as well as human skin and hair.
- the usage form of the cleaning composition of the present invention is not particularly limited, but for example, foot cleaning agents based on the bactericidal effect of ringworm bacteria, cleaning agents for specific bacteria based on sterilization of Candida, etc., deodorants based on the bactericidal effect of epidermis-derived bacteria It can be used as an effective body cleaner, atopy cleaner based on the bactericidal effect of Staphylococcus aureus and Pseudomonas aeruginosa, hand soap, dish cleaner, food cleaner and the like.
- the composition of the present invention is widely effective against bacteria adhering to animal hair, it can be suitably used particularly as an animal cleaning composition such as an animal shampoo. It is also suitable as a detergent composition for patients with human atopic dermatitis.
- the dosage form of the cleaning composition according to the present invention is not particularly limited, and for example, a concentrated cleaning composition used by diluting is also included in the present invention.
- cleaning compositions for each test example were prepared by a conventional method. Each prepared cleaning composition evaluated antibacterial activity by the following test method. The results are shown in Table 1.
- each mixed solution was diluted 10-fold with sterilized distilled water, 0.1 mL of the mixture was smeared on each medium and cultured, and the viable cell count was measured.
- the culture medium and culture conditions were 30 ° C. for 24 hours in the standard agar medium for bacteria, and 25 ° C. for 48 hours in the Sabouraud agar medium for fungi. According to the measured number of viable bacteria, antibacterial and antifungal ability of each composition against each bacterial species was evaluated according to the following evaluation criteria.
- Evaluation criteria for antibacterial activity A : The number of viable bacteria became almost zero by 15 minutes. A: A clear decreasing tendency of viable cell count was recognized by 60 minutes (1/100). ⁇ : A gradual decrease in the number of viable bacteria was observed by 60 minutes (1/10). X: A decrease in the number of viable bacteria was not recognized.
- Test Example 1-1 containing an imidazolinium betaine type amphoteric surfactant (N-lauroyl-N′-carboxymethyl-N′-hydroxyethyldiamine sodium aqueous solution) Although effective in sterilizing fungi and Escherichia coli, Test Example 1-2 containing PEG-1 lauryl glycol did not show any bactericidal effect against bacteria other than Staphylococcus aureus. However, in Test Example 1-3 in which an imidazolinium betaine-type surfactant and PEG-1 lauryl glycol, which hardly had a bactericidal effect alone, were used, the bactericidal effect of Escherichia coli and Candida was improved. It was.
- the composition of Test Example 1-4 containing 1,3-propanediol and divalent glycol containing propylene glycol the bactericidal effect of Staphylococcus aureus was improved as compared with Test Example 1-3.
- Test Example 1-5 in which the imidazolinium betaine-type amphoteric surfactant was used as another surfactant (coconut oil fatty acid amide dimethylaminoacetic acid betaine solution), a sufficient bactericidal effect was obtained for all bacterial species.
- the composition according to the present invention preferably uses imidazolinium betaine type amphoteric surfactant in combination with PEG-1 lauryl glycol, and further adds divalent glycol to increase antibacterial activity. Is preferred.
- sodium cocoyl methyl taurate (nitrogen-containing anionic surfactant), sodium cocoyl glutamate (nitrogen-containing anionic surfactant), POE (2) sodium lauryl ether sulfate (anionic surfactant), lauryl dimethyl Betaine aminoacetate (nitrogen-containing amphoteric surfactant), amidopropyldimethylamine oxide laurate (nitrogen-containing amphoteric surfactant), sodium POE lauryl ether acetate (anionic surfactant) and sodium lauroyl- ⁇ -alanine (nitrogen-containing) Anionic surfactants) are common surfactants used in cleaning compositions.
- the effectiveness of the cleaning composition of the present invention as a human body cleaning agent was examined.
- a cleaning composition having the formulation shown in Table 3 below was prepared, and a safety confirmation test was first conducted by six healthy volunteers. ⁇ Test method> After 10 days, take an appropriate amount of the cleaning composition of the formulation shown in Table 4 below on a hand or towel and perform body washing (body, face, or hair) as usual, then in accordance with the following evaluation criteria Was evaluated for safety. The results are shown in Table 5.
- Evaluation criteria for improvement effect A Any symptom of skin itching, roughness, redness, thickening, and pigmentation was improved for the use site. ⁇ : No change was observed in the use site. X: About the use site
- the cleaning composition of the present invention can be used without causing trouble for the skin of atopic dermatitis (AD) and can be expected to have an improvement effect on AD. became.
- AD bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa are likely to propagate on the skin, which may cause itching and inflammation.
- the cleaning composition of the present invention has a high bactericidal effect as described above, and is effective for subjects with AD because it uses components having low irritation to skin and eyes. it is conceivable that.
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Abstract
Description
一方で、イヌやネコ等の場合、被毛に付着した細菌・真菌等から皮膚病を発症することが多く、また、耳の構造上真菌の侵入を受け易く、外耳炎も起こしがちであることから、通常、動物用のシャンプーは、抗菌性(細菌・真菌)においてもヒト用と同等以上の効果が求められる。
また、ヒトアトピー性皮膚炎の患者においても、皮膚上における細菌の繁殖による感染症の合併は問題となっている。
しかし、これらの成分は、いずれも皮膚や目への刺激の強さやアレルギーの問題を伴うため、配合できる量は制限されてしまい、シャンプーの使用によって対象に十分な抗菌活性をもたらすことは難しかった。
このような問題から、医薬品、化粧品、食品に配合可能であり、少量で高い効果が得られる殺菌剤として、例えば、1,2-アルカンジオールと、イミダゾリン型両性界面活性剤を含む防腐殺菌剤が提案されている(特許文献1)。
本発明は上記課題に鑑みて為されたものであり、抗菌活性に優れた洗浄剤組成物を提供することを目的とする。
すなわち、本発明にかかる洗浄剤組成物は、イミダゾリニウムベタイン型両性界面活性剤と、下記一般式(I)で表されるPEG-1ラウリルグリコールを0.5~10質量%とを含むことを特徴とする。
また、前記洗浄剤組成物は、さらに、2価グリコール、ヒノキチオール、トリクロロカルバニリド、塩化ベンザルコニウムから選択される制菌効果もしくは殺菌効果を有する成分を含むことが好適である。
また、前記洗浄剤組成物は、動物用であることが好適である。
また、前記洗浄剤組成物は、ヒトアトピー性皮膚炎の患者用であることが好適である。
本発明に係る洗浄剤組成物は、イミダゾリニウムベタイン型両性界面活性剤と、PEG-1ラウリルグリコールとを含むものである。まず、前記成分について説明する。
イミダゾリニウムベタイン型両性界面活性剤
本発明に使用することのできるイミダゾリニウムベタイン型両性界面活性剤は、通常化粧品や医薬部外品に用いられるものであれば特に限定されず、例えば、下記一般式(II)で表されるものが挙げられる。
上記一般式(III)において、R1は上記一般式(II)と同様、炭素数が8~18、好ましくは10~14の直鎖又は分岐状のアルキル基、アルケニル基又はアシル基を示す。Mは対イオン(塩)を示し、例えば、ナトリウム、カリウム等のアルカリ金属イオン、マグネシウム、カルシウム等のアルカリ土類金属イオン、アンモニウム、モノエタノールアミン、ジエタノールアミン、トリエタノールアミン等のアミン類が挙げられる。
上記イミダゾリニウムベタイン型両性界面活性剤の市販品としては、例えば、ソフタゾリンLHL、ソフタゾリンLHL-SF(川研ファインケミカル社製)、オバゾリン66N、オバゾリン66N-SF(東邦化学社製)、ニッサンアノンGLM(日油社製)等が挙げられ、いずれも好適に使用することができる。
なお、本発明においては、上記イミダゾリニウムベタイン型両性界面活性剤を、単独又は2種以上を組み合わせて使用することができる。
なお、上記イミダゾリニウムベタイン型両性界面活性剤の市販原料は、通常該成分の水溶液の形で提供されている。そのような場合も、イミダゾリニウムベタイン型両性界面活性剤の純分が上記配合量範囲となるように使用すればよい。例えば、市販原料が30%濃度の水溶液として提供されている場合、本発明の組成物における配合量は5~40質量%、好ましくは10~30質量%となる。
本発明に使用されるPEG-1ラウリルグリコールは、アルカンジオール型非イオン性界面活性剤の一種であり、下記一般式(I)で表される化合物である。
このようなPEG-1ラウリルグリコールの市販品としては、ニューポールDDE-10(三洋化成工業社製)が挙げられ、これを好適に使用できる。
intermedius(膿皮症の原因菌)、Staphylococcus aureus(表皮常在菌)、Methicillin-resistant Staphylococcus aureus(多剤耐性菌)、Staphylococcus epidermidis(表皮常在菌)、Pseudomonas
aeruginosa(緑膿菌)、Pasteurella multocida(動物パスツレラ症病原菌)、Proteus
mirabilis(尿路感染症の原因菌)等の細菌;及び、Malassezia pachydermatis(外耳炎の原因菌)、Microsporum canis(白癬の原因菌)、Trichophyton
mentagrophytes(白癬の原因菌)、カンジダ等の真菌等、イヌやネコ等のペット動物に確認される微生物の殺菌に有効である。また、イミダゾリニウムベタイン型両性界面活性剤は、生物に対する安全性が高く、眼刺激性も非常に低いことから、洗浄成分としても本発明の洗浄剤組成物に適する。
また、上記の殺菌効果及び刺激性の低さから、本発明の洗浄剤組成物は、特に、ヒトアトピー性皮膚炎患者における使用に有効である。
本発明で使用し得る殺菌効果を有する成分は、化粧品や医薬部外品において通常使用される成分であって、本発明にかかる組成物の安全性を損ねないもの、或いは前記安全性を損ねない量であれば特に制限されないが、特に、1,3-ブチレングリコール、1,4-ブチレングリコール、2,3-ブチレングリコール、2,3-ジメチル-2,3-ブチレングリコール、1,3-プロパンジオール、プロピレングリコール(1,2-プロパンジオール)、ジプロピレングリコール、エチレングリコール等の2価グリコール、ヒノキチオール、トリクロロカルバニリド(TCC)、塩化ベンザルコニウム等の成分が挙げられる。2価グリコールとして好ましくは、1,3-プロパンジオール、プロピレングリコール、1,3-ブチレングリコールである。
なお、2価グリコールを使用する場合、本発明の洗浄剤組成物に対し、7質量%以上配合することにより、十分な殺菌効果を得ることができる。
また、ヒノキチオールを使用する場合、本発明の洗浄剤組成物に対し、0.001~0.5質量%配合、トリクロロカルバニリド(TCC)を使用する場合、本発明の洗浄剤組成物に対し、0.01~1質量%配合、塩化ベンザルコニウムを使用する場合、本発明の洗浄剤組成物に対し、0.01~2質量%配合することにより、十分な殺菌効果を得ることができる。
アシルタウリン塩としては、例えば、ヤシ油脂肪酸(ココイル)タウリン塩、ラウロイルタウリン塩、ミリストイルタウリン塩、パルミトイルタウリン塩、ステアロイルタウリン塩等が挙げられる。
アシルグルタミン酸塩としては、例えば、ヤシ油脂肪酸(ココイル)グルタミン酸塩、ラウロイルグルタミン酸塩、ミリストイルグルタミン酸塩、パルミトイルグルタミン酸塩、ステアロイルグルタミン酸塩等が挙げられる。
なお、上記それぞれの塩としては、例えば、ナトリウム塩、カリウム塩、マグネシウム塩、トリエタノールアミン塩等が挙げられる。
前記陰イオン性界面活性剤のうち、好ましくはラウロイルメチルタウリン塩、ヤシ油脂肪酸(ココイル)メチルタウリン塩、ラウロイルグルタミン酸塩、及び/又は、ヤシ油脂肪酸(ココイル)グルタミン酸塩であり、それぞれ好適な対イオンはナトリウム又はカリウムである。
なお、上記陰イオン性界面活性剤の市販原料は、該成分の水溶液の形で提供されていることがある。そのような場合も、陰イオン性界面活性剤の純分が上記配合量範囲となるように調整すればよい。例えば、市販原料が30%濃度の水溶液として提供されている場合、本発明の組成物における配合量は5~25質量%となる。
アミノ酸としては、例えば、中性アミノ酸(例えば、スレオニン、システイン等);塩基性アミノ酸(例えば、ヒドロキシリジン等)等が挙げられる。また、アミノ酸誘導体として、例えば、アシルサルコシンナトリウム(ラウロイルサルコシンナトリウム)、アシルグルタミン酸塩、アシルβ-アラニンナトリウム、グルタチオン、ピロリドンカルボン酸等が挙げられる。
陰イオン性界面活性剤としては、例えば、脂肪酸セッケン(例えば、ラウリン酸アトリウム、パルミチン酸ナトリウム等);高級アルキル硫酸エステル塩(例えば、ラウリル硫酸ナトリウム、ラウリル硫酸カリウム等);アルキルエーテル硫酸エステル塩(例えば、POEラウリル硫酸トリエタノールアミン等);リン酸エステル塩(POEオレイルエーテルリン酸ナトリウム、POEステアリルエーテルリン酸等);スルホコハク酸塩(例えば、ジ-2-エチルヘキシルスルホコハク酸ナトリウム、モノラウロイルモノエタノールアミドポリオキシエチレンスルホコハク酸ナトリウム、ラウリルポリプロピレングリコールスルホコハク酸ナトリウム等);アルキルベンゼンスルホン酸塩(例えば、リニアドデシルベンゼンスルホン酸ナトリウム、リニアドデシルベンゼンスルホン酸トリエタノールアミン、リニアドデシルベンゼンスルホン酸等);高級脂肪酸エステル硫酸エステル塩(例えば、硬化ヤシ油脂肪酸グリセリン硫酸ナトリウム等);N-アシルグルタミン酸塩(例えば、N-ラウロイルグルタミン酸モノナトリウム、N-ステアロイルグルタミン酸ジナトリウム、N-ミリストイル-L-グルタミン酸モノナトリウム等);硫酸化油(例えば、ロート油等);POEアルキルエーテルカルボン酸;POEアルキルアリルエーテルカルボン酸塩;α-オレフィンスルホン酸塩;高級脂肪酸エステルスルホン酸塩;二級アルコール硫酸エステル塩;高級脂肪酸アルキロールアミド硫酸エステル塩;ラウロイルモノエタノールアミドコハク酸ナトリウム;N-パルミトイルアスパラギン酸ジトリエタノールアミン;カゼインナトリウム等が挙げられる。
また、本発明に係る洗浄剤組成物の剤形も特に限定されず、例えば、希釈して使用する濃縮タイプの洗浄剤組成物も本発明に包含される。
<試験方法>
緑膿菌、大腸菌、黄色ブドウ球菌、カンジダ菌の各種菌液(2×104個/mL滅菌蒸留水)2mLと、各試験例の洗浄剤組成物2mLとを混合し、混合液の最終菌濃度を1×104個/mLとした。続いて、得られた混合液を室温暗所で15、30、60分間反応させた。前記反応後、各混合液を滅菌蒸留水で10倍に希釈し、その0.1mLを各培地に塗抹して培養した後、生菌数を測定した。培地及び培養条件は、細菌については標準寒天培地で30℃24時間とし、真菌についてはサブロー寒天培地で25℃48時間とした。
測定した生菌数に応じ、下記評価基準に従って各組成物の各菌種に対する抗菌抗カビ能を評価した。
◎:15分までに生菌数がほぼ0になった。
○:60分までに生菌数の明らかな減少傾向が認められた(1/100)。
△:60分までに生菌数の緩やかな減少傾向が認められた(1/10)。
×:生菌数の減少が認められなかった。
ところが、イミダゾリニウムベタイン型界面活性剤と、単独ではほとんど殺菌効果の見られなかったPEG-1ラウリルグリコールとを併用した試験例1-3では、大腸菌及びカンジダ菌の殺菌効果の向上が認められた。
さらに、1,3-プロパンジオール及びプロピレングリコールを含む2価グリコールを配合した試験例1-4の組成物では、試験例1-3に比べて黄色ブドウ球菌の殺菌効果の向上が認められた。
一方で、イミダゾリニウムベタイン型両性界面活性剤を他の界面活性剤(ヤシ油脂肪酸アミドジメチルアミノ酢酸ベタイン液)とした試験例1-5では、すべての菌種で十分な殺菌効果は得られなかった。
以上のことから、本発明に係る組成物は、イミダゾリニウムベタイン型両性界面活性剤と、PEG-1ラウリルグリコールを併用することが好ましく、また、さらに抗菌活性を上げるため、2価グリコールの添加が好ましい。
*3:ニューポールDDE-10(三洋化成工業株式会社製)
*4:ST-SFスーパー(日油株式会社製)
*5:アミソフトCK-22(味の素株式会社製)
*6:アミゾールCDE(川研ファインケミカル株式会社製)
また、殺菌効果を有する成分として、さらにヒノキチオールを配合した試験例2-5では、組成物の抗菌活性がより向上した(試験例2-5)。
したがって、本発明においては、組成物に抗菌活性に影響を与えず、且つ安全性の高い洗浄成分として、アシルメチルタウリン塩やアシルグルタミン酸塩等を使用することができる。
その他の界面活性剤を配合した試験例2~8は、いずれも試験例1を超える抗菌活性が認められなかったどころか、PEG-1ラウリルグリコールを単独で用いた場合(表1の試験例1-2)に認められた抗菌活性さえ打ち消され、むしろ抗菌効果がなくなる傾向にあった。
したがって、本発明に係る組成物においては、PEG-1ラウリルグリコールに対し、特にイミダゾリニウムベタイン型両性界面活性剤を用いることが好適である。
下記表3に示す処方の洗浄剤組成物を作成し、まず健常人ボランティア6名により安全性確認試験を実施した。
<試験方法>
10日間、毎日、下記表4に示す処方の洗浄剤組成物の適量を手やタオルに取って、通常どおりに身体洗浄(体、顔又は頭髪)を行った後、下記評価基準にしたがって組成物の安全性を評価した。結果を表5に示す。
*3:ニューポールDDE-10(三洋化成工業株式会社製)
*4:ST-SFスーパー(日油株式会社製)
*5:アミソフトCK-22(味の素株式会社製)
*6:アミゾールCDE(川研ファインケミカル株式会社製)
実使用試験中、皮膚(顔肌、頭皮及び身体肌)及び眼のそれぞれにおいて、トラブル(ひりつき、かゆみ、ほてり、腫れ、皮剥け、かさつき、湿疹、刺激、かゆみ、赤み、痛み、フケ、その他)が生じたかについて、下記基準で判定医の評価を得、それぞれ人数を集計した。
◎:実使用中、皮膚(顔肌、頭皮、身体肌)又は眼にトラブルはなかった。
×:実使用中、皮膚(顔肌、頭皮、身体肌)又は眼にトラブルが生じた。
毎日、適量を手やタオルに取って、通常どおりに身体洗浄(体、顔又は頭髪)を行い、1ヶ月後および3ヶ月後に下記評価基準にしたがって使用部位の改善効果について判定医の評価を得、それぞれ人数を集計した。また、使用中の皮膚(顔肌、頭皮及び身体肌)及び眼におけるトラブルの有無についても、上述の安全性の評価基準にしたがって評価した。結果を表6に示す。
◎:使用部位について、皮膚のかゆみ、かさつき、赤み、肥厚、色素沈着のいずれかの症状が改善した
△:使用部位について、症状に変化はなかった。
×:使用部位について、かゆみ、かさつき、赤み、肥厚、色素沈着のいずれかの症状が悪化した。
ADは、皮膚に黄色ブドウ球菌や緑膿菌などの細菌が繁殖しやすく、かゆみや炎症の原因となる場合がある。本発明の洗浄剤組成物は、先に示したとおり高い殺菌効果を有しており、且つ、皮膚や眼への刺激性の低い成分を用いているため、ADをもつ対象にも有効であると考えられる。
Claims (4)
- さらに、2価グリコール、ヒノキチオール、トリクロロカルバニリド、塩化ベンザルコニウムから選択される制菌効果もしくは殺菌効果を有する成分を含むことを特徴とする請求項1に記載の洗浄剤組成物。
- 動物用であることを特徴とする請求項1または2に記載の洗浄剤組成物。
- ヒトアトピー性皮膚炎患者用であることを特徴とする請求項1または2に記載の洗浄剤組成物。
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JP5086467B1 (ja) * | 2011-08-30 | 2012-11-28 | 株式会社ピーアンドピーエフ | 洗浄剤組成物 |
JP6482808B2 (ja) * | 2014-09-29 | 2019-03-13 | 株式会社アリミノ | 洗浄剤組成物 |
JP2017171625A (ja) * | 2016-03-25 | 2017-09-28 | クラシエホームプロダクツ株式会社 | 洗浄剤組成物 |
CN111356758A (zh) * | 2017-11-29 | 2020-06-30 | 三洋化成工业株式会社 | 表面活性剂和含有表面活性剂的清洗剂 |
US11111461B1 (en) | 2021-02-08 | 2021-09-07 | Bocks Inc. | Coconut-based liquid detergent composition |
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US9301908B2 (en) | 2016-04-05 |
US20140194334A1 (en) | 2014-07-10 |
DE112012003622T5 (de) | 2014-05-15 |
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