WO2012104080A2 - Installation frigorifique accessible à une personne debout et destinée notamment à la cryoconservation d'échantillons biologiques, et procédé pour faire fonctionner une telle installation - Google Patents
Installation frigorifique accessible à une personne debout et destinée notamment à la cryoconservation d'échantillons biologiques, et procédé pour faire fonctionner une telle installation Download PDFInfo
- Publication number
- WO2012104080A2 WO2012104080A2 PCT/EP2012/000451 EP2012000451W WO2012104080A2 WO 2012104080 A2 WO2012104080 A2 WO 2012104080A2 EP 2012000451 W EP2012000451 W EP 2012000451W WO 2012104080 A2 WO2012104080 A2 WO 2012104080A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- cooling
- cooling system
- space
- operator
- refrigerator
- Prior art date
Links
- 238000001816 cooling Methods 0.000 title claims abstract description 372
- 239000012472 biological sample Substances 0.000 title claims abstract description 24
- 238000000034 method Methods 0.000 title claims abstract description 17
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims abstract description 123
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 60
- 239000007788 liquid Substances 0.000 claims abstract description 53
- 239000000523 sample Substances 0.000 claims description 49
- 239000002826 coolant Substances 0.000 claims description 39
- 239000004033 plastic Substances 0.000 claims description 18
- 229920003023 plastic Polymers 0.000 claims description 18
- 238000005138 cryopreservation Methods 0.000 claims description 15
- 238000005057 refrigeration Methods 0.000 claims description 12
- 238000005192 partition Methods 0.000 claims description 7
- 238000012423 maintenance Methods 0.000 claims description 6
- 230000004888 barrier function Effects 0.000 claims description 4
- 239000001307 helium Substances 0.000 claims description 4
- 229910052734 helium Inorganic materials 0.000 claims description 4
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 claims description 4
- 238000003032 molecular docking Methods 0.000 claims description 4
- 239000010410 layer Substances 0.000 description 51
- 239000007789 gas Substances 0.000 description 20
- 230000008901 benefit Effects 0.000 description 18
- 238000009413 insulation Methods 0.000 description 14
- 230000001681 protective effect Effects 0.000 description 11
- 239000000463 material Substances 0.000 description 10
- 238000002955 isolation Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
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- 238000007689 inspection Methods 0.000 description 7
- 229910052751 metal Inorganic materials 0.000 description 7
- 239000002184 metal Substances 0.000 description 7
- 230000007774 longterm Effects 0.000 description 6
- 230000029058 respiratory gaseous exchange Effects 0.000 description 6
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
- 238000011049 filling Methods 0.000 description 5
- 239000006260 foam Substances 0.000 description 5
- 230000033001 locomotion Effects 0.000 description 5
- 239000001301 oxygen Substances 0.000 description 5
- 229910052760 oxygen Inorganic materials 0.000 description 5
- 239000012298 atmosphere Substances 0.000 description 4
- 238000013461 design Methods 0.000 description 4
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- 239000010959 steel Substances 0.000 description 3
- 238000013517 stratification Methods 0.000 description 3
- 238000009423 ventilation Methods 0.000 description 3
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
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- 238000005516 engineering process Methods 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
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- 238000011068 loading method Methods 0.000 description 2
- 239000012299 nitrogen atmosphere Substances 0.000 description 2
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- 239000011241 protective layer Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000003507 refrigerant Substances 0.000 description 2
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- 230000006641 stabilisation Effects 0.000 description 2
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- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 235000010678 Paulownia tomentosa Nutrition 0.000 description 1
- 240000002834 Paulownia tomentosa Species 0.000 description 1
- 229920005830 Polyurethane Foam Polymers 0.000 description 1
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- 210000004712 air sac Anatomy 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
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- 239000011449 brick Substances 0.000 description 1
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- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 239000000110 cooling liquid Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
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- 238000010586 diagram Methods 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- -1 eg single cells Substances 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
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- 239000007769 metal material Substances 0.000 description 1
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- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- DBSMLQTUDJVICQ-CJODITQLSA-N onametostat Chemical compound NC1=C2C=CN([C@@H]3C[C@H](CCC4=CC=C5C=C(Br)C(N)=NC5=C4)[C@@H](O)[C@H]3O)C2=NC=N1 DBSMLQTUDJVICQ-CJODITQLSA-N 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000011496 polyurethane foam Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 239000005871 repellent Substances 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000010079 rubber tapping Methods 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 239000003566 sealing material Substances 0.000 description 1
- 230000011218 segmentation Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000009751 slip forming Methods 0.000 description 1
- 239000010902 straw Substances 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0252—Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
- A01N1/0257—Stationary or portable vessels generating cryogenic temperatures
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
- F25D3/10—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D13/00—Stationary devices, e.g. cold-rooms
- F25D13/02—Stationary devices, e.g. cold-rooms with several cooling compartments, e.g. refrigerated locker systems
- F25D13/04—Stationary devices, e.g. cold-rooms with several cooling compartments, e.g. refrigerated locker systems the compartments being at different temperatures
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D3/00—Devices using other cold materials; Devices using cold-storage bodies
- F25D3/10—Devices using other cold materials; Devices using cold-storage bodies using liquefied gases, e.g. liquid air
- F25D3/102—Stationary cabinets
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D25/00—Charging, supporting, and discharging the articles to be cooled
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D29/00—Arrangement or mounting of control or safety devices
- F25D29/001—Arrangement or mounting of control or safety devices for cryogenic fluid systems
Abstract
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12702189.7A EP2671034A2 (fr) | 2011-02-02 | 2012-02-01 | Installation frigorifique accessible à une personne debout et destinée notamment à la cryoconservation d'échantillons biologiques, et procédé pour faire fonctionner une telle installation |
US13/983,342 US20140000307A1 (en) | 2011-02-02 | 2012-02-01 | Accessible cooling system, especially for cryopreserving biological samples, and method for the operation thereof |
CN201280015818.XA CN103459949B (zh) | 2011-02-02 | 2012-02-01 | 尤其用于低温贮藏生物样本的适于步行的冷却系统和用于操作这种冷却系统的方法 |
CA2825234A CA2825234C (fr) | 2011-02-02 | 2012-02-01 | Installation frigorifique accessible a une personne debout et destinee notamment a la cryoconservation d'echantillons biologiques, et procede pour faire fonctionner une telle installation |
JP2013552134A JP2014504716A (ja) | 2011-02-02 | 2012-02-01 | 生体試料の低温保存を主用途とした、歩行可能冷却システム及びその運転方法 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102011010121.7 | 2011-02-02 | ||
DE102011010121.7A DE102011010121B4 (de) | 2011-02-02 | 2011-02-02 | Begehbare Kühlanlage, insbesondere zur Kryokonservierung biologischer Proben, und Verfahren zu deren Betrieb |
Publications (3)
Publication Number | Publication Date |
---|---|
WO2012104080A2 true WO2012104080A2 (fr) | 2012-08-09 |
WO2012104080A8 WO2012104080A8 (fr) | 2012-11-08 |
WO2012104080A3 WO2012104080A3 (fr) | 2013-01-24 |
Family
ID=45562275
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2012/000451 WO2012104080A2 (fr) | 2011-02-02 | 2012-02-01 | Installation frigorifique accessible à une personne debout et destinée notamment à la cryoconservation d'échantillons biologiques, et procédé pour faire fonctionner une telle installation |
Country Status (7)
Country | Link |
---|---|
US (1) | US20140000307A1 (fr) |
EP (1) | EP2671034A2 (fr) |
JP (1) | JP2014504716A (fr) |
CN (1) | CN103459949B (fr) |
CA (1) | CA2825234C (fr) |
DE (1) | DE102011010121B4 (fr) |
WO (1) | WO2012104080A2 (fr) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102011010120A1 (de) * | 2011-02-02 | 2012-08-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Kühlanlage, insbesondere zur Kryokonservierung biologischer Proben, mit Einrichtungen für den Fall einer Havarie |
JP6600688B2 (ja) | 2015-09-09 | 2019-10-30 | ギガフォトン株式会社 | ターゲット収容装置 |
CN105211050B (zh) * | 2015-10-22 | 2017-12-12 | 上海原能细胞医学技术有限公司 | 用于冻存细胞的操作台 |
FI126430B (fi) * | 2015-12-16 | 2016-11-30 | Oy Cryon Ltd | Järjestelmä huippukylmähoitoon |
CN105737471B (zh) * | 2016-02-04 | 2018-08-31 | 上海理工大学 | 速冷便携式生物样品低温保存箱 |
CN107054914A (zh) * | 2016-12-31 | 2017-08-18 | 重庆煌固包装制造有限公司 | 一种保鲜集装箱 |
CN106829202B (zh) * | 2017-01-13 | 2019-05-31 | 北京华晨世纪生物技术有限公司 | 恒定低温存储系统及去除杜瓦雾气的方法 |
CN107691429A (zh) * | 2017-09-30 | 2018-02-16 | 曾里 | 一种梯度降温机构及其工作方法 |
CN107883629A (zh) * | 2017-12-12 | 2018-04-06 | 广州鲜之源生态冷链技术有限公司 | 一种米饭的液氮制冷装置及制冷方法 |
GB201721588D0 (en) | 2017-12-21 | 2018-02-07 | Asymptote Ltd | Container for cryopreserved samples |
EP3833916A4 (fr) | 2018-08-10 | 2022-04-27 | Celltrio, Inc. | Systèmes et procédés de stockage cryogénique |
CN112097428A (zh) * | 2020-11-13 | 2020-12-18 | 金西盟(天津)人工智能有限责任公司 | 一种三重制冷三重保护及隔热技术的生物样本液氮罐冰箱 |
CN114739075B (zh) * | 2022-03-31 | 2023-06-16 | 青岛海尔生物医疗股份有限公司 | 用于程序降温仪降温的方法及装置、程序降温仪 |
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WO2012035081A2 (fr) * | 2010-09-14 | 2012-03-22 | Quantum Production Lmited | Dispositifs de stockage cryogénique |
DE102011010120A1 (de) * | 2011-02-02 | 2012-08-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Kühlanlage, insbesondere zur Kryokonservierung biologischer Proben, mit Einrichtungen für den Fall einer Havarie |
DE102011010119A1 (de) * | 2011-02-02 | 2012-08-02 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Schutzanzug zur Verwendung in einem Kühlraum |
-
2011
- 2011-02-02 DE DE102011010121.7A patent/DE102011010121B4/de not_active Expired - Fee Related
-
2012
- 2012-02-01 US US13/983,342 patent/US20140000307A1/en not_active Abandoned
- 2012-02-01 EP EP12702189.7A patent/EP2671034A2/fr not_active Withdrawn
- 2012-02-01 WO PCT/EP2012/000451 patent/WO2012104080A2/fr active Application Filing
- 2012-02-01 JP JP2013552134A patent/JP2014504716A/ja active Pending
- 2012-02-01 CN CN201280015818.XA patent/CN103459949B/zh not_active Expired - Fee Related
- 2012-02-01 CA CA2825234A patent/CA2825234C/fr not_active Expired - Fee Related
Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
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GB812210A (en) | 1956-11-21 | 1959-04-22 | British Oxygen Co Ltd | Preservation of food and other perishable materials |
EP1223393A2 (fr) | 2001-01-12 | 2002-07-17 | Chart, Inc. | Recipient de stockage à liquide cryogénique |
US20060156753A1 (en) | 2003-07-18 | 2006-07-20 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. | Device and method for handling a probe |
US20060283197A1 (en) | 2003-10-08 | 2006-12-21 | Uwe Schon | Cooling apparatus used for cryonic preservation, and corresponding operating method |
US20070267419A1 (en) | 2004-10-01 | 2007-11-22 | Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E. V. | Cryo-Device and Associated Operational Method |
DE102005031648A1 (de) | 2005-07-06 | 2007-01-11 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren und Vorrichtung zur Kryokonservierung biologischer Proben |
WO2008009840A1 (fr) | 2006-07-19 | 2008-01-24 | Cryo Diffusion | Dispositif de cryopréservation à sec de produits, notamment d'échantillons de matière biologique. |
Also Published As
Publication number | Publication date |
---|---|
DE102011010121B4 (de) | 2016-09-01 |
CA2825234C (fr) | 2018-11-27 |
WO2012104080A8 (fr) | 2012-11-08 |
CN103459949A (zh) | 2013-12-18 |
JP2014504716A (ja) | 2014-02-24 |
US20140000307A1 (en) | 2014-01-02 |
EP2671034A2 (fr) | 2013-12-11 |
WO2012104080A3 (fr) | 2013-01-24 |
CN103459949B (zh) | 2016-06-01 |
DE102011010121A1 (de) | 2012-08-02 |
CA2825234A1 (fr) | 2012-08-09 |
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