WO2011088688A1 - Véhicule de médicament à base de micelles polymères comprenant un acide aminé en tant que stabilisateur - Google Patents

Véhicule de médicament à base de micelles polymères comprenant un acide aminé en tant que stabilisateur Download PDF

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Publication number
WO2011088688A1
WO2011088688A1 PCT/CN2010/077254 CN2010077254W WO2011088688A1 WO 2011088688 A1 WO2011088688 A1 WO 2011088688A1 CN 2010077254 W CN2010077254 W CN 2010077254W WO 2011088688 A1 WO2011088688 A1 WO 2011088688A1
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WO
WIPO (PCT)
Prior art keywords
pharmaceutical composition
amino acid
polymer
block copolymer
amphiphilic block
Prior art date
Application number
PCT/CN2010/077254
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English (en)
Chinese (zh)
Inventor
吴建梅
Original Assignee
南京泛太化工医药研究所
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Filing date
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Application filed by 南京泛太化工医药研究所 filed Critical 南京泛太化工医药研究所
Publication of WO2011088688A1 publication Critical patent/WO2011088688A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

L'invention concerne un véhicule de médicament à base de micelles polymères comprenant un acide aminé en tant que stabilisateur et son procédé de préparation. Le véhicule de médicament à base de micelles polymères est composé d'un polymère séquencé amphiphile et d'un acide aminé. Le polymère séquencé amphiphile est un polymère diséquencé ou un polymère triséquencé et de préférence le mPEG-PDLLA. L'acide aminé est choisi parmi 20 acides aminés courants. Le rapport en poids entre le polymère amphiphile et l'acide aminé est de 100/0,01 à 1,00/99,99.
PCT/CN2010/077254 2010-01-19 2010-09-25 Véhicule de médicament à base de micelles polymères comprenant un acide aminé en tant que stabilisateur WO2011088688A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201010001047.1 2010-01-19
CN2010100010471A CN101773465B (zh) 2010-01-19 2010-01-19 以氨基酸为稳定剂的聚合物胶束载药系统

Publications (1)

Publication Number Publication Date
WO2011088688A1 true WO2011088688A1 (fr) 2011-07-28

Family

ID=42510142

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2010/077254 WO2011088688A1 (fr) 2010-01-19 2010-09-25 Véhicule de médicament à base de micelles polymères comprenant un acide aminé en tant que stabilisateur

Country Status (2)

Country Link
CN (1) CN101773465B (fr)
WO (1) WO2011088688A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITBO20120368A1 (it) * 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
US9498442B2 (en) 2010-03-05 2016-11-22 Alfa Wassermann S.P.A. Rifaximin powder, process for preparing the same an controlled release compositions containing said rifaximin useful for obtaining a long-lasting effect
EP3278799A4 (fr) * 2015-04-03 2018-12-05 Sichuan Kelun Pharmaceutical Research Institute Co. Ltd. Composition pharmaceutique de nanoparticules d'albumine et de docétaxel, procédé de préparation de ladite composition et son utilisation
US10258610B2 (en) 2011-07-29 2019-04-16 Alfasigma S.P.A. Pharmaceutical compositions comprising rifaximin, processes for their preparation and their use in the treatment of vaginal infections
US10285944B2 (en) 2005-03-07 2019-05-14 Alfasigma S.P.A. Gastroresistant pharmaceutical formulations containing rifaximin
US10428086B2 (en) 2014-05-12 2019-10-01 Alfasigma S.P.A. Solvated crystal form of rifaximin, production, compositions and uses thereof
US10703763B2 (en) 2005-03-03 2020-07-07 Alfasigma S.P.A. Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101773465B (zh) * 2010-01-19 2012-11-07 南京泛太化工医药研究所 以氨基酸为稳定剂的聚合物胶束载药系统
CN102391517B (zh) * 2011-08-18 2013-06-26 中山大学 一种能智能释放药物的纳米胶束及其制备方法和应用
CN103120644B (zh) * 2011-11-17 2016-12-21 山东绿叶制药有限公司 生物功能性蛋白大分子的两亲嵌段共聚物胶束及其制备和应用
CN103772686B (zh) 2012-10-26 2015-01-07 苏州雷纳药物研发有限公司 一种两亲性嵌段共聚物及其制备方法、以及该共聚物与抗肿瘤药物形成的胶束载药系统
CN104415003A (zh) * 2013-08-27 2015-03-18 成都市绿科华通科技有限公司 一种含聚吡咯烷酮的高分子纳米药物微胶囊
CN104415007A (zh) * 2013-08-28 2015-03-18 成都市绿科华通科技有限公司 一种肿瘤细胞微环境响应性纳米胶束的制备方法
CN104415011A (zh) * 2013-08-30 2015-03-18 成都市绿科华通科技有限公司 细胞微环境pH敏感性胶束的制备方法
CN104434794A (zh) * 2013-09-16 2015-03-25 成都市绿科华通科技有限公司 新型阿霉素肿瘤细胞抑制性胶束的制备方法
CN103976978A (zh) * 2014-04-30 2014-08-13 成都市绿科华通科技有限公司 聚吡咯型高分子药物载体胶束
CN105287402B (zh) * 2014-07-16 2018-01-16 西南药业股份有限公司 多西他赛聚合物胶束冻干制剂与专用溶剂的组合物
CN104523674B (zh) * 2014-12-11 2017-10-24 广州市上为医药科技有限公司 一种以奥沙利铂为主药成分的注射用组合物
CN107303273A (zh) * 2016-04-18 2017-10-31 北京大学 一种增强肿瘤细胞摄取的pH敏感聚合物胶束组合物
CN111035764B (zh) * 2018-10-14 2021-09-07 深圳市健元医药科技有限公司 一种治疗类风湿性关节炎的组合物及其制备方法
CN110483785B (zh) * 2019-07-01 2020-05-19 中山大学 一种三嵌段聚合物、载药纳米胶束、纳米药物及其制备方法和应用
CN110642968B (zh) * 2019-09-18 2021-07-06 云南师范大学 双酶响应性哑铃形超两亲分子及其制备方法和用途
CN114831938B (zh) * 2022-05-24 2023-04-18 郑州大学第一附属医院 一种包载阿托伐他汀钙的聚合物胶束、制剂及制备方法
CN116570734B (zh) * 2023-07-13 2023-10-13 四川大学华西医院 一种具有靶向功能的核壳壳结构药物胶束及其制备方法

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US20040197408A1 (en) * 2002-12-30 2004-10-07 Angiotech International Ag Amino acids in micelle preparation
CN101773465A (zh) * 2010-01-19 2010-07-14 南京泛太化工医药研究所 以氨基酸为稳定剂的聚合物胶束载药系统

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040197408A1 (en) * 2002-12-30 2004-10-07 Angiotech International Ag Amino acids in micelle preparation
CN101773465A (zh) * 2010-01-19 2010-07-14 南京泛太化工医药研究所 以氨基酸为稳定剂的聚合物胶束载药系统

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10703763B2 (en) 2005-03-03 2020-07-07 Alfasigma S.P.A. Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations
US10285944B2 (en) 2005-03-07 2019-05-14 Alfasigma S.P.A. Gastroresistant pharmaceutical formulations containing rifaximin
US9498442B2 (en) 2010-03-05 2016-11-22 Alfa Wassermann S.P.A. Rifaximin powder, process for preparing the same an controlled release compositions containing said rifaximin useful for obtaining a long-lasting effect
US10258610B2 (en) 2011-07-29 2019-04-16 Alfasigma S.P.A. Pharmaceutical compositions comprising rifaximin, processes for their preparation and their use in the treatment of vaginal infections
ITBO20120368A1 (it) * 2012-07-06 2014-01-07 Alfa Wassermann Spa Composizioni comprendenti rifaximina e amminoacidi, cristalli di rifaximina derivanti da tali composizioni e loro uso.
WO2014006576A1 (fr) * 2012-07-06 2014-01-09 Alfa Wassermann S.P.A. Compositions pharmaceutiques comprenant de la rifaximine et des acides aminés, procédé de préparation et utilisation correspondants
US20140079783A1 (en) * 2012-07-06 2014-03-20 Alfa Wassermann Spa Pharmaceutical Compositions Comprising Rifaximin and Amino acids, Preparation Methods and Use Thereof
US9452157B2 (en) 2012-07-06 2016-09-27 Alfa Wassermann S.P.A Pharmaceutical compositions comprising rifaximin and amino acids, preparation methods and use thereof
EA028769B1 (ru) * 2012-07-06 2017-12-29 Альфа Вассерманн С.П.А. Фармацевтические композиции, содержащие рифаксимин и аминокислоты, способ их получения и их применение
US10428086B2 (en) 2014-05-12 2019-10-01 Alfasigma S.P.A. Solvated crystal form of rifaximin, production, compositions and uses thereof
US10493054B2 (en) 2015-04-03 2019-12-03 Sichuan Kelun Pharmaceutical Research Institute Co. Ltd. Docetaxel albumin nanoparticle pharmaceutical composition, preparation method therefor and use thereof
EP3278799A4 (fr) * 2015-04-03 2018-12-05 Sichuan Kelun Pharmaceutical Research Institute Co. Ltd. Composition pharmaceutique de nanoparticules d'albumine et de docétaxel, procédé de préparation de ladite composition et son utilisation
AU2016240119B2 (en) * 2015-04-03 2020-10-22 Sichuan Kelun Pharmaceutical Research Institute Co. Ltd. Docetaxel albumin nanoparticle pharmaceutical composition, preparation method therefor and use thereof
US11395812B2 (en) 2015-04-03 2022-07-26 Sichuan Kelun Pharmaceutical Research Institute Co. Ltd. Docetaxel albumin nanoparticle pharmaceutical composition, preparation method therefor and use thereof

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Publication number Publication date
CN101773465A (zh) 2010-07-14
CN101773465B (zh) 2012-11-07

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