WO2010134790A3 - 마크로락틴 에이 및 그 유도체를 유효성분으로 함유하는 항염제 조성물 - Google Patents

마크로락틴 에이 및 그 유도체를 유효성분으로 함유하는 항염제 조성물 Download PDF

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Publication number
WO2010134790A3
WO2010134790A3 PCT/KR2010/003239 KR2010003239W WO2010134790A3 WO 2010134790 A3 WO2010134790 A3 WO 2010134790A3 KR 2010003239 W KR2010003239 W KR 2010003239W WO 2010134790 A3 WO2010134790 A3 WO 2010134790A3
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WO
WIPO (PCT)
Prior art keywords
macrolactin
present
inflammatory
formation
interleukin
Prior art date
Application number
PCT/KR2010/003239
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English (en)
French (fr)
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WO2010134790A2 (ko
Inventor
지용훈
김동희
강재선
김천규
정성욱
황성우
강경란
Original Assignee
대우제약 주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 대우제약 주식회사 filed Critical 대우제약 주식회사
Priority to JP2012511768A priority Critical patent/JP5395260B2/ja
Priority to CN2010800225359A priority patent/CN102438613B/zh
Priority to ES10777977.9T priority patent/ES2440329T3/es
Priority to CA2761254A priority patent/CA2761254C/en
Priority to EP10777977.9A priority patent/EP2433631B1/en
Priority to US13/321,112 priority patent/US9089543B2/en
Publication of WO2010134790A2 publication Critical patent/WO2010134790A2/ko
Publication of WO2010134790A3 publication Critical patent/WO2010134790A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

본 발명은 신규한 바실러스 균주인 바실러스 폴리퍼멘티큐스 KJS-2(Bacillus polyfermenticus KJS-2, KCCM10769P) 균주에서 생산되는 마크로락틴 에이(macrolactin A), 7-O-말로닐 마크로락틴 에이(7-O-malonyl macrolactin A), 7-O-숙시닐 마크로락틴 에이(7-O-succinyl macrolactin A)와 같은 마크로락틴류 화합물들의 항염물질로서의 용도에 관한 것이다. 본 발명이 제공하는 상기 마크로락틴류 화합물들은 염증매개인자 생성 관련 단백질인 유도형 산화질소 합성효소(inducible nitric oxide synthetase, iNOS) 및 사이클로옥시게나아제-2(cyclooxygenase-2, COX-2) 발현 및 생성을 강력히 저해함으로써 그 대사산물인 산화질소(nitric oxid, NO)와 프로스타글란딘 이투(prostagladin E2, PGE2)의 생성을 억제하는 것이 확인되었고 염증을 촉진하는 염증성 사이토카인(pro-inflammatory cytokine)인 종양괴사인자-알파(tumor necrosis factor-alpha, TNF-α), 인터류킨-1 베타(interleukin-1β, IL-1β), 인터류킨-6(interleukin-6, IL-6) 및 과립구 대식세포 콜로니-자극 인자(granulocyte macrophage colony-stimulating factor, GM-CSF)의 생성을 억제하는데 탁월한 효과가 있음이 확인되었다. 따라서, 본 발명의 바실러스 폴리퍼멘티쿠스 KJS-2(Bacillus polyfermenticus KJS-2) 균주가 생산하는 상기 마크로락틴류 화합물들은 우수한 항염증제를 제공할 수 있다.
PCT/KR2010/003239 2009-05-22 2010-05-24 마크로락틴 에이 및 그 유도체를 유효성분으로 함유하는 항염제 조성물 WO2010134790A2 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2012511768A JP5395260B2 (ja) 2009-05-22 2010-05-24 マクロラクチンａ及びその誘導体を有効成分として含有する抗炎症性組成物
CN2010800225359A CN102438613B (zh) 2009-05-22 2010-05-24 含有大环内酯菌素a及其衍生物作为有效成分的消炎药物组合物
ES10777977.9T ES2440329T3 (es) 2009-05-22 2010-05-24 Composición antiinflamatoria que contiene macrolactina y un derivado de la misma como ingredientes activos
CA2761254A CA2761254C (en) 2009-05-22 2010-05-24 Anti-inflammatory composition containing macrolactin a and a derivative thereof as active ingredients
EP10777977.9A EP2433631B1 (en) 2009-05-22 2010-05-24 Anti-inflammatory composition containing macrolactin a and a derivative thereof as active ingredients
US13/321,112 US9089543B2 (en) 2009-05-22 2010-05-24 Anti-inflammatory composition containing macrolactin A and a derivative thereof as active ingredients

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR20090044900 2009-05-22
KR10-2009-0044900 2009-05-22
KR1020100029016A KR101070324B1 (ko) 2009-05-22 2010-03-31 마크로락틴 에이 및 그 유도체를 유효성분으로 함유하는 항염제 조성물
KR10-2010-0029016 2010-03-31

Publications (2)

Publication Number Publication Date
WO2010134790A2 WO2010134790A2 (ko) 2010-11-25
WO2010134790A3 true WO2010134790A3 (ko) 2011-04-14

Family

ID=43504179

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2010/003239 WO2010134790A2 (ko) 2009-05-22 2010-05-24 마크로락틴 에이 및 그 유도체를 유효성분으로 함유하는 항염제 조성물

Country Status (8)

Country Link
US (1) US9089543B2 (ko)
EP (1) EP2433631B1 (ko)
JP (1) JP5395260B2 (ko)
KR (1) KR101070324B1 (ko)
CN (1) CN102438613B (ko)
CA (1) CA2761254C (ko)
ES (1) ES2440329T3 (ko)
WO (1) WO2010134790A2 (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101271593B1 (ko) * 2010-07-16 2013-06-11 대우제약 주식회사 마크로락틴 에이 및 그 유도체를 유효성분으로 함유하는 항혈관신생효과를 갖는 조성물
WO2012177927A1 (en) 2011-06-21 2012-12-27 Mayo Foundation For Medical Education And Research Transgenic animals capable of being induced to delete senescent cells
KR20140119023A (ko) 2011-12-13 2014-10-08 버크 인스티튜트 포 리서치 온 에이징 의료 요법을 개선하는 방법
WO2013158664A2 (en) 2012-04-17 2013-10-24 Kythera Biopharmaceuticals, Inc. Use of engineered viruses to specifically kill senescent cells
US9901081B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse for determining the role of senescent cells in cancer
US9901080B2 (en) 2012-08-23 2018-02-27 Buck Institute For Research On Aging Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells
KR101658350B1 (ko) * 2015-02-06 2016-09-30 경성대학교 산학협력단 고지혈증 치료에 유용한 약학 조성물
WO2021241873A1 (ko) * 2020-05-29 2021-12-02 경성대학교 산학협력단 제2형 중증급성호흡기증후군 코로나바이러스 감염 질환의 예방 또는 치료용 조성물
WO2022128051A1 (en) 2020-12-14 2022-06-23 Symrise Ag Medicament for fighting inflammatory conditions of human skin (ii)
WO2022128052A1 (en) 2020-12-14 2022-06-23 Symrise Ag Medicament for fighting inflammatory conditions of human skin
KR102671165B1 (ko) 2021-05-24 2024-06-03 경성대학교 산학협력단 마크로락틴 유도체, 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는 구제역 바이러스의 감염 질환 예방 또는 치료용 조성물

Citations (3)

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KR20060012393A (ko) * 2004-08-03 2006-02-08 학교법인 명지학원 감자 더뎅이병을 억제하는 신규한 바실러스 균주, 상기균주가 생산하는 항생물질 및 이를 함유하는 미생물제제
WO2006032683A1 (de) * 2004-09-21 2006-03-30 Helmholtz-Zentrum für Infektionsforschung GmbH Antibiotikum und verfahren zur herstellung
WO2008114954A1 (en) * 2007-03-16 2008-09-25 Inje University Industry-Academic Cooperation Foundation Antibacterial macrolactin a that bacillus polyfermenticus kjs-2 produced in

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* Cited by examiner, † Cited by third party
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US20070161581A1 (en) * 2004-01-21 2007-07-12 Nobuto Minowa Novel aminoglycoside antibiotics effective against methicillin resistant staphylococcus auerus (mrsas)

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060012393A (ko) * 2004-08-03 2006-02-08 학교법인 명지학원 감자 더뎅이병을 억제하는 신규한 바실러스 균주, 상기균주가 생산하는 항생물질 및 이를 함유하는 미생물제제
WO2006032683A1 (de) * 2004-09-21 2006-03-30 Helmholtz-Zentrum für Infektionsforschung GmbH Antibiotikum und verfahren zur herstellung
WO2008114954A1 (en) * 2007-03-16 2008-09-25 Inje University Industry-Academic Cooperation Foundation Antibacterial macrolactin a that bacillus polyfermenticus kjs-2 produced in

Non-Patent Citations (1)

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Title
See also references of EP2433631A4 *

Also Published As

Publication number Publication date
US20120071549A1 (en) 2012-03-22
WO2010134790A2 (ko) 2010-11-25
CN102438613B (zh) 2013-09-25
CN102438613A (zh) 2012-05-02
JP2012527452A (ja) 2012-11-08
EP2433631A4 (en) 2012-10-24
CA2761254C (en) 2014-02-11
KR20100126184A (ko) 2010-12-01
EP2433631B1 (en) 2013-10-16
CA2761254A1 (en) 2010-11-25
US9089543B2 (en) 2015-07-28
EP2433631A2 (en) 2012-03-28
KR101070324B1 (ko) 2011-10-06
JP5395260B2 (ja) 2014-01-22
ES2440329T3 (es) 2014-01-28

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