WO2014020467A3 - Process for the preparation of pyrazole substituted aminoheteroaryl compounds - Google Patents

Process for the preparation of pyrazole substituted aminoheteroaryl compounds Download PDF

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Publication number
WO2014020467A3
WO2014020467A3 PCT/IB2013/055699 IB2013055699W WO2014020467A3 WO 2014020467 A3 WO2014020467 A3 WO 2014020467A3 IB 2013055699 W IB2013055699 W IB 2013055699W WO 2014020467 A3 WO2014020467 A3 WO 2014020467A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
present
pyrazole substituted
aminoheteroaryl compounds
substituted aminoheteroaryl
Prior art date
Application number
PCT/IB2013/055699
Other languages
French (fr)
Other versions
WO2014020467A2 (en
Inventor
Saswata Lahiri
Govind Singh
Amit Tewari
Madan Singh
Shivaji SHELKE
Sachin NAIN
Sathyanarayana Girigani
Original Assignee
Fresenius Kabi Oncology Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fresenius Kabi Oncology Ltd filed Critical Fresenius Kabi Oncology Ltd
Publication of WO2014020467A2 publication Critical patent/WO2014020467A2/en
Publication of WO2014020467A3 publication Critical patent/WO2014020467A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to an improved process for the preparation of pyrazole substituted aminoheteroaryl compounds. More particularly, the present invention provides highly pure 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4- yl)pyridin-2-amine, its intermediates and preparation thereof. The process of the present invention is simple, convenient, does not use expensive chemicals and avoids use of tedious purification techniques. Invention also provides process intermediates, useful not only in the synthesis, but also useful for providing desired compound with high purity.
PCT/IB2013/055699 2012-07-30 2013-07-11 Process for the preparation of pyrazole substituted aminoheteroaryl compounds WO2014020467A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2354DE2012 2012-07-30
IN2354/DEL/2012 2012-07-30

Publications (2)

Publication Number Publication Date
WO2014020467A2 WO2014020467A2 (en) 2014-02-06
WO2014020467A3 true WO2014020467A3 (en) 2014-03-27

Family

ID=48949195

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2013/055699 WO2014020467A2 (en) 2012-07-30 2013-07-11 Process for the preparation of pyrazole substituted aminoheteroaryl compounds

Country Status (1)

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WO (1) WO2014020467A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106279112A (en) * 2015-06-12 2017-01-04 浙江九洲药业股份有限公司 A kind of Crizotinib intermediate and its preparation method and application
US10377940B2 (en) 2016-09-20 2019-08-13 Saudi Arabian Oil Company Cement having cross-linked polymers
CN106632263B (en) * 2016-12-19 2019-02-22 河南应用技术职业学院 A kind of synthetic method of (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010048131A1 (en) * 2008-10-21 2010-04-29 Vertex Pharmaceuticals Incorporated C-met protein kinase inhibitors
WO2011042389A2 (en) * 2009-10-09 2011-04-14 Bayer Cropscience Ag Phenylpyri(mi)dinylazoles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ552946A (en) 2004-08-26 2010-09-30 Pfizer Pyrazole-substituted aminoheteroaryl compounds as protein kinase inhibitors
CN101023064B (en) 2004-08-26 2011-02-16 辉瑞大药厂 Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
CA2632286C (en) 2005-12-05 2011-11-15 Pfizer Products Inc. Use of (r)-3-[1-(2,6-dichloro-3-fluror-phenyl)-ethoxyl]-5-(1-piperidin-4-yl-1h-pyrazol-4-yl)-pyridin-2-ylamine for treatment of cancer

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010048131A1 (en) * 2008-10-21 2010-04-29 Vertex Pharmaceuticals Incorporated C-met protein kinase inhibitors
WO2011042389A2 (en) * 2009-10-09 2011-04-14 Bayer Cropscience Ag Phenylpyri(mi)dinylazoles

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
PIETER D. DE KONING ET AL: "Fit-for-Purpose Development of the Enabling Route to Crizotinib (PF-02341066)", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 15, no. 5, 16 September 2011 (2011-09-16), pages 1018 - 1026, XP055078841, ISSN: 1083-6160, DOI: 10.1021/op200131n *

Also Published As

Publication number Publication date
WO2014020467A2 (en) 2014-02-06

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