WO2020242719A3 - Inhibitors of rna-binding proteins, compositions thereof, and therapeutic uses thereof - Google Patents

Inhibitors of rna-binding proteins, compositions thereof, and therapeutic uses thereof Download PDF

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Publication number
WO2020242719A3
WO2020242719A3 PCT/US2020/031058 US2020031058W WO2020242719A3 WO 2020242719 A3 WO2020242719 A3 WO 2020242719A3 US 2020031058 W US2020031058 W US 2020031058W WO 2020242719 A3 WO2020242719 A3 WO 2020242719A3
Authority
WO
WIPO (PCT)
Prior art keywords
rna
compositions
inhibitors
binding proteins
therapeutic uses
Prior art date
Application number
PCT/US2020/031058
Other languages
French (fr)
Other versions
WO2020242719A2 (en
Inventor
Jeff AUBE
Sudeshna ROY
Liang Xu
Xiaoquing WU
Lan LAN
Original Assignee
The University Of North Carolina At Chapel Hill
University Of Kansas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The University Of North Carolina At Chapel Hill, University Of Kansas filed Critical The University Of North Carolina At Chapel Hill
Priority to US17/607,003 priority Critical patent/US20220213052A1/en
Priority to EP20813936.0A priority patent/EP3963085A4/en
Publication of WO2020242719A2 publication Critical patent/WO2020242719A2/en
Publication of WO2020242719A3 publication Critical patent/WO2020242719A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

The present technology is directed to compounds that inhibit of the interaction of RNA-binding protiens with RNA, intermediaes thereof, compositions thereof, and methods of treatment utilizing such compounds, where the compounds are of Formula (I).
PCT/US2020/031058 2019-05-01 2020-05-01 Inhibitors of rna-binding proteins, compositions thereof, and therapeutic uses thereof WO2020242719A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US17/607,003 US20220213052A1 (en) 2019-05-01 2020-05-01 Inhibitors of rna-binding proteins, compositions thereof, and therapeutic uses therof
EP20813936.0A EP3963085A4 (en) 2019-05-01 2020-05-01 Inhibitors of rna-binding proteins, compositions thereof, and therapeutic uses thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962841600P 2019-05-01 2019-05-01
US62/841,600 2019-05-01

Publications (2)

Publication Number Publication Date
WO2020242719A2 WO2020242719A2 (en) 2020-12-03
WO2020242719A3 true WO2020242719A3 (en) 2021-02-25

Family

ID=73553089

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2020/031058 WO2020242719A2 (en) 2019-05-01 2020-05-01 Inhibitors of rna-binding proteins, compositions thereof, and therapeutic uses thereof

Country Status (3)

Country Link
US (1) US20220213052A1 (en)
EP (1) EP3963085A4 (en)
WO (1) WO2020242719A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20230131501A1 (en) * 2020-03-30 2023-04-27 University Of Kansas THERAPEUTIC USES OF INHIBITORS OF THE RNA-BINDING PROTEIN HuR
CN117448332A (en) * 2023-08-07 2024-01-26 大连理工大学 Sequence optimization method for enhancing mRNA protein expression by using RNA binding protein

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153642A (en) * 1996-11-11 2000-11-28 Pharmacia & Upjohn S.P.A. Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5843937A (en) * 1996-05-23 1998-12-01 Panorama Research, Inc. DNA-binding indole derivatives, their prodrugs and immunoconjugates as anticancer agents
US20050137234A1 (en) * 2003-12-19 2005-06-23 Syrrx, Inc. Histone deacetylase inhibitors
TWI412367B (en) * 2006-12-28 2013-10-21 Medarex Llc Chemical linkers and cleavable substrates and conjugates thereof
HUE035798T2 (en) * 2008-11-03 2018-05-28 Syntarga Bv Cc-1065 analogs and their conjugates
WO2011050325A1 (en) * 2009-10-22 2011-04-28 Vertex Pharmaceuticals Incorporated Compositions for treatment of cystic fibrosis and other chronic diseases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6153642A (en) * 1996-11-11 2000-11-28 Pharmacia & Upjohn S.P.A. Benzoheterocyclic distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ALLAN ET AL.: "N-Benzyl-1-heteroaryl-3-(trifluoromethyl)-1H-pyrazole-5-carboxamides as inhibitors of co-activator associated arginine methyltransferase 1 (CARM1", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, vol. 19, 2009, pages 1218 - 1223, XP025937250, DOI: 10.1016/j.bmcl.2008.12.075 *
DATABASE PubChem COMPOUND 26 April 2019 (2019-04-26), "5-(1H-Indole-7-carbonylamino)​-1-benzofuran-2-carboxylic acid | C18H12N2O4", XP055795746, Database accession no. CID 137990205 *
DATABASE PubChem Compound NCBI; 23 July 2010 (2010-07-23), Database accession no. CID 46424910 *

Also Published As

Publication number Publication date
EP3963085A4 (en) 2022-09-14
WO2020242719A2 (en) 2020-12-03
US20220213052A1 (en) 2022-07-07
EP3963085A2 (en) 2022-03-09

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